Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| 0046251 | Phosphotyrosine protein phosphatases I | 7-175 | 1.8e-43 | 138.6 | In-house | 4-158 (159) | alignment | ||
Range on Protein: 7-175
Range on HMM: 4-158/159.0
NQKKVLFVCLGNICRSTMAEIVLRGLVHSRGILDD-FQIDSAGTSSYHIGDTPDPRTVQSCNQnmgraiseeslkHFKSIPlHRARQFTDEDFSKFDYIF
. |||||||.|||||| ||| .|| |....|. |. ...||||||..|.|. ||||.|. ... . .. |||||.|.||| .||.|.
mkkkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalhvgeppdpravavlke............lgidls.hrarqlteedfeefdlil
AMDESNLSNIKKVLKHsttkdNHIATIKRLGEYHTHKK---INVEDPYYGDMSNFNICFNHVHDCLVNFLKEI
|||.|||....... . .... . .|.|. .. . ..|.|||||....| ......... ..|...
amddsnlrdllrlapg.....dargkvllllefagllellhwdvpDPyyggleaFeevldlieeaveallekl
|
|||||||||
| 0053360 | Phosphotyrosine protein phosphatases I | 7-175 | 1.2e-42 | 135.8 | In-house | 4-156 (157) | alignment | ||
Range on Protein: 7-175
Range on HMM: 4-156/157.0
NQKKVLFVCLGNICRSTMAEIVLRGLVHSRGILDDFQIDSAGTSSYHIGDTPDPRTVQSCNQnmgraiseeslkHFKSIPlHRARQFTDEDFSKFDYIFA
. |||||||.|||||| ||| .|| |.. .|. |.|..||||||..|.|. .|||.|. ... . .. |||||.|.||. .||.|..
kmkkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGtsalhvggpvdpravevlae............lgidls.hrarqlteedleefdlilt
MDESNLSNIKKVLKHSttkDNHIATIKRLGEYHTHKKINVEDPYYGDMSNFNICFNHVHDCLVNFLKEI
||.|||... .. . .... . .|.|. . .|.|||||....| ......... ..|...
mddsnleellplfpgl...leakgkvllllefagllhwdvpDPyyggleafelvldlieeaveallell
|
|||||||||
| 0042188 | Phosphotyrosine protein phosphatases I | 7-175 | 6.6e-37 | 117.0 | In-house | 3-143 (146) | alignment | ||
Range on Protein: 7-175
Range on HMM: 3-143/146.0
NQKKVLFVCLGNICRSTMAEIVLRGLVHSRgilddFQIDSAGTSSYHIGDTPDPRTVQSCNQNmGRAISEeslkhfksiplHRARQFTDEDFSKFDYIFA
. |||||||.|||||| ||| .|| |...| ...||||||.||.|...|||.|. .... | ||. |||||.|.||. .||....
kkkkvlfvCtgNicRSpmAeallrhllgdr.....vevdSAGtsayhvgepvdpravevlael.gidisg...........hrarqlteedleefDlvlt
MDESNLSNIKKVLKhsttkDNHIATIKRLGEYHthkkiNVEDPYYGDmSNFNICFNHVHDCLVNFLKEI
||.|||... .. ..... . .|.|. .|.|||||. . | ......... ..|...
mddsnlrdllplfp.....gaakgkvllllefw.....dvpDPyygg.eafeevldlieeavkallell
|
|||||||||
| subfamily_LMWPTP_pd | Subfamily LMWPTP | 8-174 | 1.5e-68 | 219.4 | In-house | 1-151 (152) | alignment | ||
Range on Protein: 8-174
Range on HMM: 1-151/152.0
QKKVLFVCLGNICRSTMAEIVLRGLVHSRGILDDFQIDSAGTSSYHIGDTPDPRTVqSCNQNMGRAISeeslkhfksiplHRARQFTDEDFSKFDYIFAM
.||||||||||||||..||.||| ||...|. .|...|||..||||.|..||.|.. |.....|...| |||||.|.||||.||||.||
kkkvlfvClGniCrspiaEavlrklvekkglkedwkvdsaaissyhvGkepdkRal.silkkhglkss............hrarqitkedfsefdyilam
DESNLSNIKKVLKhsTTKDNHiATIKRLGEYHTHKKINVEDPYYGDMSNFNICFNHVHDCLVNFLKE
|||||...||. | ..|... |....||||....| ..|||||||...|.........|. .|||.
Desnlkelkklak..ekkesk.akvlllgeydkkgkeiiedpyygdekdFeavykqikecckaflkk
|
|||||||||
| 0048765 | Phosphotyrosine protein phosphatases I | 9-175 | 2.1e-42 | 134.9 | In-house | 3-153 (154) | alignment | ||
Range on Protein: 9-175
Range on HMM: 3-153/154.0
KKVLFVCLGNICRSTMAEIVLRGLVHSRGILDDFQIDSAGTSSYHIGDTPDPRTVQSCNQnmgraiseeslkHFKSIPlHRARQFTDEDFSKFDYIFAMD
|||||||.|||||| ||| .|| |.. .|. |....||||||.||.|. .|||.|. ... . .. |||||.|.||. .||.|..||
kkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGtsayhvgepvdpravevlae............lgidls.hrarqlteedleefdliltmd
ESNLSNIKKVLKHSttkDNHIATIKRLGEYHTHKKINVEDPYYGDMSNFNICFNHVHDCLVNFLKEI
.|||... .. . .... . .|.|.. . .|.|||||....|. ......... ..|...
dsnleellplfpgl...leakgkvllllefagllhwdvpDPyyggleafeevldlieeaveallell
|
|||||||||
| LMWPc_SSU72_ArsC | 9-162 | 3.3e-35 | 111.7 | In-house | 1-124 (126) | alignment | |||
Range on Protein: 9-162
Range on HMM: 1-124/126.0
KKVLFVCLGNICRSTMAEIVLRGLVHSrgildDFQIDSAGTSSYHIGDTPDPRTVQSCNQNMGraiseeslkhfkSIPlHRARQFTDEDFSKFDYIFAMD
||||||||||||||.||| ||. .|.. .....||||.... |...|.|.|. ...| .. |..||...||...||.|..||
kkvlfvClgNicRSpmAeavlkkavkk.....glnvsSaGtgaavpgksidsravellkengi............elk.hkprqlqeedlkefdliltmd
ESNLSNIKKVLKHSTTKDNHIAtikrlgeyhthkKINVEDPYYGDMSNFNICFN
|.| ..... |....||. |. ...|.|||.|..|.|. ...
ernkdevlellperatkkvhll............nldvkDpyegaesgfeevld
|
|||||||||
| 0047618 | Phosphotyrosine protein phosphatases I | 9-174 | 1.7e-33 | 105.7 | In-house | 2-135 (137) | alignment | ||
Range on Protein: 9-174
Range on HMM: 2-135/137.0
KKVLFVCLGNICRSTMAEIVLRGLVHSRgilddFQIDSAGTSSYHigdtPDPRTVQSCNQnMGRAISEeslkhfksiplHRARQFTDEDFSKFDYIFAMD
|||||||.|||||| |||..|| |...| ...|||||.... .|||.|. ... .| ||. ||..|....|. .||....||
kkvlfvCtgNicRSpmAeallrhllgdr.....vevdSAGtepag....vdpravevlae.lgidisg...........hrskqldeldlpefdlvltmd
ESNLSNIKKVLKHSTTKDNhiatikrlgeyhthkkiNVEDPYYGD------MSNFNICFNHVHDCLVNFLKE
.|.|... . .. ... .|.|||||. . | ......... ..|..
dsalealpllapaalrlhw.................dvpDPyygggteeekleafervldlieerveallel
|
|||||||||
| LMWPc_SSU72 | 9-174 | 4.3e-30 | 95.4 | In-house | 1-137 (137) | alignment | |||
Range on Protein: 9-174
Range on HMM: 1-137/137.0
KKVLFVCLGNICRSTMAEIVLRGLVHsrgildDFQIDSAGTSSYHIGDTPDPRTVQSCNQNMGraiseeslkhfkSIPlHRARQFTDEDFSKFDYIFAMD
.||||||..||.|| .|| .|. .. ....||||.|...|...|..... ...| || ........|...|||......
lkvlfVCasNinRSmeAeallkeale......glevkSaGtgslvpgpsidkpaeelykenGl............sik.eapeklqeeelekfDlvitle
ESNLSNIKKVLKHStT---KDNHIAtikrlgeyhthkKINVEDPYYGDMSNFNICFNHVHDCLVNFLKE
|... .. . |.. . . |. .....||.......|. ... . ... ..|.|
ervfdavvedlper.selkrkvhvi............nvdikDpheeaiegfkaildlieervkellae
|
|||||||||
| 0047572 | Phosphotyrosine protein phosphatases I | 9-172 | 5.2e-29 | 91.0 | In-house | 3-128 (130) | alignment | ||
Range on Protein: 9-172
Range on HMM: 3-128/130.0
KKVLFVCLGNICRSTMAEIVLRGLVhsrgiLDDFQIDSAGTSsyhiGDTPDPRTVQSCNQnMGRAISEEslkhfksiplhRARQFTDEDFSKFDYIFAMD
|||||||.||.||| |||..|| |. |.....||||. |. .|||.|. ... .| ||. |..|...... .||....||
kkvlfvCtgNscRSpmAeallrhll.....gdrvevySAGte....gsgvdpravevlae.lgidisgh...........rskqldelllpefdlvitmd
ESNLSNIKKVLKHSTTKDNhiatikrlgeyhthkkiNVEDPYYGDMSNFNICFNHVHDCLVNFL
.|.|... . . ... ...|||.|... | ... ..... ..|
dsalealpllapaalrlhw.................dipDPygggleafrevrdlierrvlall
|
|||||||||
| 0051181 | Phosphotyrosine protein phosphatases I | 10-173 | 3.8e-31 | 98.0 | In-house | 1-123 (124) | alignment | ||
Range on Protein: 10-173
Range on HMM: 1-123/124.0
KVLFVCLGNICRSTMAEIVLRGLVHSrgilddFQIDSAGTssyHIGDTPDPRTVQSCNQnmgraiseeslkHFKSIPlHRARQFTDEDFSKFDYIFAMDE
||||||.|||||| ||| .|| |... ...||||| |.|. .|||.|. ... . .. .|..|....|. .||....||.
kvlfvCtgNicRSpmAeallrhllgd......vevdSAGt...hpggpvdpravevlae............lgidls.lrskqldeldleefdlvltmdd
SNLSNIKKVLKhsttkdnhiatikrlgeyhTHKKINVEDPYYGDMSNFNICFNHVHDCLVNFLK
||| .. . . ..|.|||||... | ......... ..|.
snlcpllplap...................lllhwdvpDPyyggleefeevldlieervealle
|
|||||||||
| subfamily_Sponge-LMWPTP-like_pd | Subfamily Sponge-LMWPTP-like | 10-71 | 2.7e-07 | 20.3 | In-house | 2-65 (173) | alignment | ||
Range on Protein: 10-71
Range on HMM: 2-65/173.0
KVLFVCLGNICRSTMAEIVLRGLVHSRGILddFQIDSAGT----SSYHIGDTPDPRTVQSCNQNMG
|.|||| || ||| || || . |. . . ||| . ..| .... . . |
kllfvcsgnscrspmamivaekmeaereki..iesdsaagnfkngkfvasqspavnaikaleaeyg
|
|||||||||
| LMWPc | Low molecular weight phosphotyrosine protein phosphatase | 11-172 | 5.9e-34 | 107.9 | Pfam-A | 1-138 (138) | alignment | ||
Range on Protein: 11-172
Range on HMM: 1-138/138.0
VLFVCLGNICRSTMAEIVLRGLVHSRgILDDFQIDSAGTSSYhIGDTPDPRTVQSCNQNmGRAISEeslkhfksiplHRARQFTDEDFSKFDYIFAMDES
|||||.|||||| ||| .|| |.... . |....|||||... .|...|||.|. .... | .||. |||||...|....||.|...||.
vlfvCtgNicRSpmAeallralleka.lgdkvevdSAGteal.vgesvdpravevlkek.gidisg...........hrarqlseeelkefDliltldee
NLSNIKKVLKHstTKDNHIATIKRlgeyhthkKINVEDPYYGDMSNFNICFNHVHDCLVNFL
.......| . .| ... ... . ...|||......|. ... . ... ..|
aarelcpvape..kkeakvvllge........qwdipDPygkeeeefeevrdeieervkkll
|
|||||||||
| LMWPc | Low molecular weight phosphotyrosine protein phosphatase | 11-172 | 5.9e-34 | 107.9 | In-house | 1-138 (138) | alignment | ||
Range on Protein: 11-172
Range on HMM: 1-138/138.0
VLFVCLGNICRSTMAEIVLRGLVHSRgILDDFQIDSAGTSSYhIGDTPDPRTVQSCNQNmGRAISEeslkhfksiplHRARQFTDEDFSKFDYIFAMDES
|||||.|||||| ||| .|| |.... . |....|||||... .|...|||.|. .... | .||. |||||...|....||.|...||.
vlfvCtgNicRSpmAeallralleka.lgdkvevdSAGteal.vgesvdpravevlkek.gidisg...........hrarqlseeelkefDliltldee
NLSNIKKVLKHstTKDNHIATIKRlgeyhthkKINVEDPYYGDMSNFNICFNHVHDCLVNFL
.......| . .| ... ... . ...|||......|. ... . ... ..|
aarelcpvape..kkeakvvllge........qwdipDPygkeeeefeevrdeieervkkll
|
|||||||||