Gene acp1 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC2
Superfamily CC2
Family LMWPTP
Subfamily LMWPTP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP055_AA protein Get Run
DdisP055_AA_6-175 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0046251 Phosphotyrosine protein phosphatases I 7-175 1.8e-43 138.6 In-house 4-158 (159) alignment
Range on Protein: 7-175
Range on HMM: 4-158/159.0
NQKKVLFVCLGNICRSTMAEIVLRGLVHSRGILDD-FQIDSAGTSSYHIGDTPDPRTVQSCNQnmgraiseeslkHFKSIPlHRARQFTDEDFSKFDYIF
. |||||||.|||||| ||| .|| |....|. |. ...||||||..|.|. ||||.|. ...            .  ..  |||||.|.||| .||.|.
mkkkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalhvgeppdpravavlke............lgidls.hrarqlteedfeefdlil

AMDESNLSNIKKVLKHsttkdNHIATIKRLGEYHTHKK---INVEDPYYGDMSNFNICFNHVHDCLVNFLKEI
|||.|||....... .     .... . .|.|. .. .   ..|.|||||....|  ......... ..|...
amddsnlrdllrlapg.....dargkvllllefagllellhwdvpDPyyggleaFeevldlieeaveallekl

0053360 Phosphotyrosine protein phosphatases I 7-175 1.2e-42 135.8 In-house 4-156 (157) alignment
Range on Protein: 7-175
Range on HMM: 4-156/157.0
NQKKVLFVCLGNICRSTMAEIVLRGLVHSRGILDDFQIDSAGTSSYHIGDTPDPRTVQSCNQnmgraiseeslkHFKSIPlHRARQFTDEDFSKFDYIFA
. |||||||.|||||| ||| .|| |.. .|. |.|..||||||..|.|. .|||.|. ...            .  ..  |||||.|.||. .||.|..
kmkkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGtsalhvggpvdpravevlae............lgidls.hrarqlteedleefdlilt

MDESNLSNIKKVLKHSttkDNHIATIKRLGEYHTHKKINVEDPYYGDMSNFNICFNHVHDCLVNFLKEI
||.|||... ..  .     .... . .|.|.  .   .|.|||||....|  ......... ..|...
mddsnleellplfpgl...leakgkvllllefagllhwdvpDPyyggleafelvldlieeaveallell

0042188 Phosphotyrosine protein phosphatases I 7-175 6.6e-37 117.0 In-house 3-143 (146) alignment
Range on Protein: 7-175
Range on HMM: 3-143/146.0
NQKKVLFVCLGNICRSTMAEIVLRGLVHSRgilddFQIDSAGTSSYHIGDTPDPRTVQSCNQNmGRAISEeslkhfksiplHRARQFTDEDFSKFDYIFA
. |||||||.|||||| ||| .|| |...|     ...||||||.||.|...|||.|. .... |  ||.           |||||.|.||. .||....
kkkkvlfvCtgNicRSpmAeallrhllgdr.....vevdSAGtsayhvgepvdpravevlael.gidisg...........hrarqlteedleefDlvlt

MDESNLSNIKKVLKhsttkDNHIATIKRLGEYHthkkiNVEDPYYGDmSNFNICFNHVHDCLVNFLKEI
||.|||... ..       ..... . .|.|.      .|.|||||. . |  ......... ..|...
mddsnlrdllplfp.....gaakgkvllllefw.....dvpDPyygg.eafeevldlieeavkallell

subfamily_LMWPTP_pd Subfamily LMWPTP 8-174 1.5e-68 219.4 In-house 1-151 (152) alignment
Range on Protein: 8-174
Range on HMM: 1-151/152.0
QKKVLFVCLGNICRSTMAEIVLRGLVHSRGILDDFQIDSAGTSSYHIGDTPDPRTVqSCNQNMGRAISeeslkhfksiplHRARQFTDEDFSKFDYIFAM
.||||||||||||||..||.||| ||...|. .|...|||..||||.|..||.|.. |.....|...|            |||||.|.||||.||||.||
kkkvlfvClGniCrspiaEavlrklvekkglkedwkvdsaaissyhvGkepdkRal.silkkhglkss............hrarqitkedfsefdyilam

DESNLSNIKKVLKhsTTKDNHiATIKRLGEYHTHKKINVEDPYYGDMSNFNICFNHVHDCLVNFLKE
|||||...||. |  ..|... |....||||....| ..|||||||...|.........|. .|||.
Desnlkelkklak..ekkesk.akvlllgeydkkgkeiiedpyygdekdFeavykqikecckaflkk

0048765 Phosphotyrosine protein phosphatases I 9-175 2.1e-42 134.9 In-house 3-153 (154) alignment
Range on Protein: 9-175
Range on HMM: 3-153/154.0
KKVLFVCLGNICRSTMAEIVLRGLVHSRGILDDFQIDSAGTSSYHIGDTPDPRTVQSCNQnmgraiseeslkHFKSIPlHRARQFTDEDFSKFDYIFAMD
|||||||.|||||| ||| .|| |.. .|. |....||||||.||.|. .|||.|. ...            .  ..  |||||.|.||. .||.|..||
kkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGtsayhvgepvdpravevlae............lgidls.hrarqlteedleefdliltmd

ESNLSNIKKVLKHSttkDNHIATIKRLGEYHTHKKINVEDPYYGDMSNFNICFNHVHDCLVNFLKEI
.|||... ..  .     .... . .|.|.. .   .|.|||||....|. ......... ..|...
dsnleellplfpgl...leakgkvllllefagllhwdvpDPyyggleafeevldlieeaveallell

LMWPc_SSU72_ArsC 9-162 3.3e-35 111.7 In-house 1-124 (126) alignment
Range on Protein: 9-162
Range on HMM: 1-124/126.0
KKVLFVCLGNICRSTMAEIVLRGLVHSrgildDFQIDSAGTSSYHIGDTPDPRTVQSCNQNMGraiseeslkhfkSIPlHRARQFTDEDFSKFDYIFAMD
||||||||||||||.||| ||. .|..     .....||||.... |...|.|.|. ...|              ..  |..||...||...||.|..||
kkvlfvClgNicRSpmAeavlkkavkk.....glnvsSaGtgaavpgksidsravellkengi............elk.hkprqlqeedlkefdliltmd

ESNLSNIKKVLKHSTTKDNHIAtikrlgeyhthkKINVEDPYYGDMSNFNICFN
|.| ..... |....||. |.             ...|.|||.|..|.|. ...
ernkdevlellperatkkvhll............nldvkDpyegaesgfeevld

0047618 Phosphotyrosine protein phosphatases I 9-174 1.7e-33 105.7 In-house 2-135 (137) alignment
Range on Protein: 9-174
Range on HMM: 2-135/137.0
KKVLFVCLGNICRSTMAEIVLRGLVHSRgilddFQIDSAGTSSYHigdtPDPRTVQSCNQnMGRAISEeslkhfksiplHRARQFTDEDFSKFDYIFAMD
|||||||.|||||| |||..|| |...|     ...|||||....    .|||.|. ... .|  ||.           ||..|....|. .||....||
kkvlfvCtgNicRSpmAeallrhllgdr.....vevdSAGtepag....vdpravevlae.lgidisg...........hrskqldeldlpefdlvltmd

ESNLSNIKKVLKHSTTKDNhiatikrlgeyhthkkiNVEDPYYGD------MSNFNICFNHVHDCLVNFLKE
.|.|...  . .. ...                   .|.|||||.      .  |  ......... ..|..
dsalealpllapaalrlhw.................dvpDPyygggteeekleafervldlieerveallel

LMWPc_SSU72 9-174 4.3e-30 95.4 In-house 1-137 (137) alignment
Range on Protein: 9-174
Range on HMM: 1-137/137.0
KKVLFVCLGNICRSTMAEIVLRGLVHsrgildDFQIDSAGTSSYHIGDTPDPRTVQSCNQNMGraiseeslkhfkSIPlHRARQFTDEDFSKFDYIFAMD
.||||||..||.|| .|| .|.  ..       ....||||.|...|...|..... ...|              ||  ........|...|||......
lkvlfVCasNinRSmeAeallkeale......glevkSaGtgslvpgpsidkpaeelykenGl............sik.eapeklqeeelekfDlvitle

ESNLSNIKKVLKHStT---KDNHIAtikrlgeyhthkKINVEDPYYGDMSNFNICFNHVHDCLVNFLKE
|... .. . |..  .   .  |.             .....||.......|. ... . ... ..|.|
ervfdavvedlper.selkrkvhvi............nvdikDpheeaiegfkaildlieervkellae

0047572 Phosphotyrosine protein phosphatases I 9-172 5.2e-29 91.0 In-house 3-128 (130) alignment
Range on Protein: 9-172
Range on HMM: 3-128/130.0
KKVLFVCLGNICRSTMAEIVLRGLVhsrgiLDDFQIDSAGTSsyhiGDTPDPRTVQSCNQnMGRAISEEslkhfksiplhRARQFTDEDFSKFDYIFAMD
|||||||.||.||| |||..|| |.      |.....||||.    |. .|||.|. ... .|  ||.            |..|...... .||....||
kkvlfvCtgNscRSpmAeallrhll.....gdrvevySAGte....gsgvdpravevlae.lgidisgh...........rskqldelllpefdlvitmd

ESNLSNIKKVLKHSTTKDNhiatikrlgeyhthkkiNVEDPYYGDMSNFNICFNHVHDCLVNFL
.|.|...  .  . ...                   ...|||.|... |  ... ..... ..|
dsalealpllapaalrlhw.................dipDPygggleafrevrdlierrvlall

0051181 Phosphotyrosine protein phosphatases I 10-173 3.8e-31 98.0 In-house 1-123 (124) alignment
Range on Protein: 10-173
Range on HMM: 1-123/124.0
KVLFVCLGNICRSTMAEIVLRGLVHSrgilddFQIDSAGTssyHIGDTPDPRTVQSCNQnmgraiseeslkHFKSIPlHRARQFTDEDFSKFDYIFAMDE
||||||.|||||| ||| .|| |...      ...|||||   |.|. .|||.|. ...            .  ..  .|..|....|. .||....||.
kvlfvCtgNicRSpmAeallrhllgd......vevdSAGt...hpggpvdpravevlae............lgidls.lrskqldeldleefdlvltmdd

SNLSNIKKVLKhsttkdnhiatikrlgeyhTHKKINVEDPYYGDMSNFNICFNHVHDCLVNFLK
||| ..    .                    .  ..|.|||||... |  ......... ..|.
snlcpllplap...................lllhwdvpDPyyggleefeevldlieervealle

subfamily_Sponge-LMWPTP-like_pd Subfamily Sponge-LMWPTP-like 10-71 2.7e-07 20.3 In-house 2-65 (173) alignment
Range on Protein: 10-71
Range on HMM: 2-65/173.0
KVLFVCLGNICRSTMAEIVLRGLVHSRGILddFQIDSAGT----SSYHIGDTPDPRTVQSCNQNMG
|.|||| || ||| || ||   .   |. .   . |||        .   ..|   .... . . |
kllfvcsgnscrspmamivaekmeaereki..iesdsaagnfkngkfvasqspavnaikaleaeyg

LMWPc Low molecular weight phosphotyrosine protein phosphatase 11-172 5.9e-34 107.9 Pfam-A 1-138 (138) alignment
Range on Protein: 11-172
Range on HMM: 1-138/138.0
VLFVCLGNICRSTMAEIVLRGLVHSRgILDDFQIDSAGTSSYhIGDTPDPRTVQSCNQNmGRAISEeslkhfksiplHRARQFTDEDFSKFDYIFAMDES
|||||.|||||| ||| .|| |.... . |....|||||... .|...|||.|. .... | .||.           |||||...|....||.|...||.
vlfvCtgNicRSpmAeallralleka.lgdkvevdSAGteal.vgesvdpravevlkek.gidisg...........hrarqlseeelkefDliltldee

NLSNIKKVLKHstTKDNHIATIKRlgeyhthkKINVEDPYYGDMSNFNICFNHVHDCLVNFL
.......|  .  .| ... ...         . ...|||......|. ... . ... ..|
aarelcpvape..kkeakvvllge........qwdipDPygkeeeefeevrdeieervkkll

LMWPc Low molecular weight phosphotyrosine protein phosphatase 11-172 5.9e-34 107.9 In-house 1-138 (138) alignment
Range on Protein: 11-172
Range on HMM: 1-138/138.0
VLFVCLGNICRSTMAEIVLRGLVHSRgILDDFQIDSAGTSSYhIGDTPDPRTVQSCNQNmGRAISEeslkhfksiplHRARQFTDEDFSKFDYIFAMDES
|||||.|||||| ||| .|| |.... . |....|||||... .|...|||.|. .... | .||.           |||||...|....||.|...||.
vlfvCtgNicRSpmAeallralleka.lgdkvevdSAGteal.vgesvdpravevlkek.gidisg...........hrarqlseeelkefDliltldee

NLSNIKKVLKHstTKDNHIATIKRlgeyhthkKINVEDPYYGDMSNFNICFNHVHDCLVNFL
.......|  .  .| ... ...         . ...|||......|. ... . ... ..|
aarelcpvape..kkeakvvllge........qwdipDPygkeeeefeevrdeieervkkll