Gene DDB_G0283187 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPG1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP075_AA protein Get Run
DdisP075_AA_3-295 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 4-295 1.5e-111 366.3 In-house 26-328 (473) alignment 
Range on Protein: 4-295
Range on HMM: 26-328/473.0
STFNLDHCIEKLQKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKL
. ..|| .|| | |...|||...... |..||.| .|.|..|.  ...|.||.|||..| |..... |  |.....||||.||||..|.|.. || .||.
glldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalki

RYPSRITLLRGNHESRQITQVYGFYGECMRKYgNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPdP
.||....|||||||.|.....|||..|...|| .  ....| | ...| .||.|.. |..|||||||.  ..|||. ..|..|.|..|.| |.|||||  
kypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.w

DREG--------FVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNK------LSTVWSAPNYCNRCGNMASIVEVNEKLeRYFNTYA
. .|        |. |.||||| .|.|.. .||..|....|.|.|. ...||. |||.|      . ||.||||||.|.|| |......|.| ..| .. 
eddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfd

AAPQSL
..|. |
psphpl
0053225 Metallo-dependent phosphatases 5-292 5.3e-101 330.8 In-house 6-292 (293) alignment 
Range on Protein: 5-292
Range on HMM: 6-292/293.0
TFNLDHCIEKLQKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLR
...|| .|| | .. .|.|...... ...||.|..|.|..|.. ...|.||.||...| |..... | .|.....||||.||||..|.|.. || .|||.
lllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkll

YPSRITLLRGNHESRQITQVYGFYGECMRKYGNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDpD
||....|||||||.......|||..|..||||.  .|..... ...| .||.|.. |..|||||||.  ..|||. ..|....|.||.| |.|||||| .
ypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.l

REGFVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNTYAAAP
..|.. |.||.|. .| ...||||..|....|||.||...|||...||.|| ||.|||||..|.||........|.| . | ..|. .
wsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP2C_pd Subfamily PPP2C 6-294 5.6e-162 530.7 In-house 2-289 (290) alignment 
Range on Protein: 6-294
Range on HMM: 2-289/290.0
FNLDHCIEKLQKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRY
 .||..||||..|. | ||..||...|.||.| .||||||...||||.|||||||.|.||.|||||..||||||||||||||||.||||..||..||.||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PSRITLLRGNHESRQITQVYGFYGECMRKYGNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDpDR
..|||.|||||||||||||||||.||.|||||..||||||..||||...|..||.|.|.|||||||. ..|.|. |||.||||.||.|.|.|||||| ||
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.dr

EGFVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNTYAAAPQS
.|.. |.|||||..|||.. .| ..|....|.|||||.|.||....|....|..||||||.||||.|.|.|...||...|.....||..
ggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_PPP4C_pd Subfamily PPP4C 7-293 3e-133 436.5 In-house 2-287 (288) alignment 
Range on Protein: 7-293
Range on HMM: 2-287/288.0
NLDHCIEKLQKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYP
.||. ||||..||.. |...|..  |..|.|. |||||.. ||||| ||.||||||.||.||.||..|.||||||||.||||..||||. || .||.|||
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

SRITLLRGNHESRQITQVYGFYGECMRKYGNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDpDRE
 ||||.|||||||||||||||| ||.||||. .||.| ||.|||||.|||||. |.|||||||||  ..|.|...|| ||||.||.|.|.|||||. | |
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.dae

GFVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNTYAAAPQ
|.  | ||||| .|.||. .| ..|... |.||||| |.||.  |..|. ||||||||| ||||.|.|.|..|.|.. |. . ||..
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaa
0049330 Metallo-dependent phosphatases 7-293 1.3e-107 352.4 In-house 16-301 (309) alignment 
Range on Protein: 7-293
Range on HMM: 16-301/309.0
NLDHCIEKLQKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYP
.|| .||.| |. .|.|...... .|.||.|.||.|..|.  ...|.||.|||..| |..... |  |.....||||.||||..|.|.. || .|||.||
lldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllyp

SRITLLRGNHESRQITQVYGFYGECMRKYGnPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDRE
....|||||||.|.....|||..|..|||| . .|..|......| .||.|.. |.||||||||. |..|||. |.|..|.|..| | |.|||||.|.||
dnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpire

GFVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNTYAAAPQ
||....||.|. .| ... |||. |....|||.|.....||.|.||.|| ||.||||||.|.||.....|..|.|...| .. ..|.
gfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
subfamily_PPG1_pd Subfamily PPG1 8-294 1.6e-186 611.6 In-house 1-299 (300) alignment 
Range on Protein: 8-294
Range on HMM: 1-299/300.0
LDHCIEKLQKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPS
||.|.|||||.|.|||.|.||.|||.||||..||||.||||||||||||||||||||||||||||.|||||||||||||||..||||||||..|||||||
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITLLRGNHESRQITQVYGFYGECMRKY-GNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPD----
|||||||||||||||||||||.||.||| ||..||||.||.||||..||||||.|||||||||||.||||||||||||.||||||||.|.|||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

-----PDREG--FVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNTYAAAPQS
     |||||  ||.|||||||||||||...||.||.|..||||||||..|||.||||||||||||||||.||||.|||.|..||.|||||.|..||.|
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapes
subfamily_PPP6C_pd Subfamily PPP6C 8-294 7e-130 425.3 In-house 2-287 (290) alignment 
Range on Protein: 8-294
Range on HMM: 2-287/290.0
LDHCIEKLQKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPS
||. ||  .||. |||. .|.. |....||. ||||| ..|||||.||.||||||..|.|. ||| |||.|.||||.|||||.|.||...| .||..||.
ldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypd

RITLLRGNHESRQITQVYGFYGECMRKYGNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDpDREG
||||||||||||||||||||| ||..|||| ..|||.|..|| |..|||||| . ||||||||    .|||.|..| ||.|..||..|..||||. | | 
ritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvet

FVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNTYAAAPQS
.. |.||||| .|. ||  |...|... |.||||| ..|..  ||.|| ||||||||| ||||.|||...... || .. . | |..
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpde
subfamily_PPP3C_pd Subfamily PPP3C 8-279 2.6e-82 270.0 In-house 28-311 (452) alignment 
Range on Protein: 8-279
Range on HMM: 28-311/452.0
LDHCIEKLQKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPS
|.   |.. |   | |... .| ..  .|| .|... |. .|.||.||.||||||.|..|..||.  .|.||||||||||||.|.|..  | .||. |||
levlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiayps

RITLLRGNHESRQITQVYGFYGECMRKYGNpTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDRE-
.. |||||||.| .|. . |  ||  ||.. .|.. ..| || | .||....  .||||||||   |.|.|| ||||.|.|. |.| |.|||||  | . 
tlfllrGnhecrhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledyge

-----GFV-ESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDN------KLSTVWSAPNYCNRCGNMASIVEVNE
      || .| ||  | |.   . .|||.|..  |||||.   .||.   ..       | |..|||||..   | |.......
ekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_PPP7C_pd Subfamily PPP7C 9-183 2e-34 112.0 In-house 21-201 (383) alignment 
Range on Protein: 9-183
Range on HMM: 21-201/383.0
DHCIEKLQKCEILPESTIKEITDKMKELLISESNVQEIR----SPVTVVGDVHGQFYDVLEIF-KIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKL
.. ||.... ..|    . .|  . |. | .  |....       ||| ||.||.. |.| |. | |   .. .|.| ||.|||| .||| . .| .| |
eklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalll

RYPSRITLLRGNHESRQITQVYGFYGECMRKY--GNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSAlSIDQIKVLDR
 ||  . | |||||   .   |||  | . ||   .  . . . ..| .| .|..||| |. ||||.| .. ... .. ..|
vypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdkt.dlelldkier
subfamily_PPP5C_pd Subfamily PPP5C 10-292 5.2e-83 271.7 In-house 23-310 (322) alignment 
Range on Protein: 10-292
Range on HMM: 23-310/322.0
HCIEKLQKCEILPESTIKEITDKMKELLISESNVQEIRSP----VTVVGDVHGQFYDVLEIFKIGGQC-PDTNYLFLGDYVDRGYHSVETISLLTCLKLR
. .|...| . |..  . .|  ..|||| ... . ||. .    .|| ||.||||||.|.||.. |.  ..  ||| ||.|||| .|||.| .| ..|| 
ellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkll

YPSRITLLRGNHESRQITQVYGFYGECMRKYGNpTVWKYFTEMFDYLSVAAIIDEAIYCVHGGL-SPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDP
|| .. | |||||| .. ..||| ||.  || . .| . |||.|..| .| .|.| .  ||||| |   ...|... .||... |.||.| ..|||||..
yPnhfflsrGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe

dREGFVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEV-NEKLERYFNTYAAAP
 ..|  .|.|| |  .| ||| .||..|....|||.|.. ..||.   | || ||.||||||.. ||....... ...|.  |.|. | .
.anGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeave
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 11-289 1.2e-89 293.3 In-house 14-292 (298) alignment 
Range on Protein: 11-289
Range on HMM: 14-292/298.0
CIEKLQKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRIT
.... . .... |. .... .. |... . . . |. .|..| ||.|||. |.| .|. .|  ||.|||||||||||| ...|.| || . |..||... 
slsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnff

LLRGNHESRQITQVYGFYGECMRKYGNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDREGFVE
|||||||  .| .||||| || |.| . .... | ..|. | ..|.| . |.|.|||||.   |.||.. | | .. ..|    |.||.||.   .|. |
llrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwae

SQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNTYA
..||... .|.||   .|.. ..  ..||||.  |||. . ..|| |..|||.||..  | |....|.|||.  |. . 
nsrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlk
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 12-286 1.9e-69 226.8 In-house 7-284 (290) alignment 
Range on Protein: 12-286
Range on HMM: 7-284/290.0
IEKLQKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITL
..|    . . .. | || .|..|.|     . |. .|...|||.|||. ..|. |.  |. |. ..|||||||||| .|.|   || |.|.||. .. |
llkygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhl

LRGNHESRQITQVYGFYGECMRKYGNpTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRF--QEVPNEGALSDILWSDPDPDREGF-
|||||| |.. ..|||. | .|| |.  .|| . ..|. ||. | ... | |.|||.|.   | . .| | .   .   .||   |.||.||. |.    
lrgnhevrkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddti

-VESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFN
 .. ||.    .||..   .|..  .. |.|||..  .|.. |||.|| ||.||| |. .  |. .|..| | ||  . 
alnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsiv
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 14-286 1.7e-77 253.2 In-house 3-277 (287) alignment 
Range on Protein: 14-286
Range on HMM: 3-277/287.0
KLQKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLR
|    . . .. | |. .|..|.|   . . |...|.|.|||.|||. |.| ||.  |. |...||||||||||| .|.| . || .||..|| .. |||
kygvldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllr

GNHESRQITQVYGFYGECMRKYGnPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQ--EVPNEGALSDILWSDPDPDREGFV-E
|||| ..| ..|||. | .||..   ..| | ..|..|.. |.... | |.|||.||   |.|..| | . .     .||   |.||.||. | ..|  .
GnhevkkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfeln

SQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFN
 .|.    .|| .   .|.. ... |.|||..  .||. |||..| ||.||| |. .  |....| |.. ||  | 
kiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfv
subfamily_PPZ_pd Subfamily PPZ 16-285 8.8e-77 251.5 In-house 20-288 (300) alignment 
Range on Protein: 16-285
Range on HMM: 20-288/300.0
QKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGN
 |   | .| | .|  | .||.... .. |.  .| .|||||||. |.| .|   |  | .|||||||||||| .|.||| || | |..||  . |||||
tknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgn

HESRQITQVYGFYGECMRKyGNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDREGFVESQRGA
||  ..|.||||| || |.  |  .|| | . |. | .|||.   |.||||||||   |.|.|. . |  .||. | . |.|||||    . . . .|| 
hecanvtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergv

GYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYF
 | | |    .||..  .. . ||| .  |||. . |  | ||.||||||    |  ... |.| |   |
sycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsf
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 16-286 3.9e-73 239.3 In-house 18-290 (297) alignment 
Range on Protein: 16-286
Range on HMM: 18-290/297.0
QKCEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGN
  .... |  . .. |   ... .. .. |. .|. |.||.|||| |.| .|. ||  | .||||||||||||  |.||| || . |...|. . |||||
llskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgn

HESRQITQVYGFYGECMRKYGNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSP---SALSIDQIKVLDRFQEVpNEGALSDILWSDPDPDREGFVESQ
||   . .||||| || ..|    ..  | ..|..| .. .| . | |.||||||     ...| .. ..| .|  .|. ..|.||.||     ||.| |
hecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenq

RGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFN
||||  .|.|  |.   . |.. . ||||.  |||. .   || |..||| || .  | |... ..|||.  |.
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfe
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 17-287 8.8e-77 251.0 In-house 4-271 (280) alignment 
Range on Protein: 17-287
Range on HMM: 4-271/280.0
KCeiLPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNH
.|  . |  |... .| |..|  .. . |. .||.|.||.|||. |.| .|.  .  ||.|||||||||||| . .| | || . |.||| .. .|||||
ac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnh

ESRQITQVYGFYGECMRKYGNpTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDREGFVESQRGAG
|  .| . |||. |..|.| .  ... | |..| | ..|..   |.|.|||||.   |.|... | |  . ..|    |.||.||. .  |. |..||. 
evisinrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

YSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNT
. .|..|   . .  ... |.| ||.  |||. . |.|| ||.|||.|..   | |... |.|.|.  |. 
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfev
subfamily_PPP1C_pd Subfamily PPP1C 18-286 1.2e-101 332.7 In-house 7-274 (282) alignment 
Range on Protein: 18-286
Range on HMM: 7-274/282.0
CEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHE
   | |..|.....|..|.|.|.. . |.. ||..|||.|||..|.| .|...|  |..|||||||||||| .|.||| || ..|..||... |||||||
evklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhe

SRQITQVYGFYGECMRKYGNPtVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDREGFVESQRGAGY
| .|...|||| || |.|..  .|| ||..|..| .||..|| |.||||||||.  |..||. . |  |||..| | |.|||||| ...|. |..||  .
sasinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsf

SYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFN
..||||  .|||.|... |.||||.  |||.   ...| ||.||||||.. .|......|.|.|   |.
tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfq
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 18-289 2e-70 230.4 In-house 3-273 (280) alignment 
Range on Protein: 18-289
Range on HMM: 3-273/280.0
CEILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHE
|...    |  |   .. ... |||. |  .|. |.||.| |. |.  .| . |. |. . .||||||||| . .| . || |||.||  || |||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYGECMRKYGNPtVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDREGFVESQRGAGY
.  . ..|||| ||  |||   .|  |   |. . ....| . . |.||||||  . .| |. . |  |  . | | |.|||||    ||.. | ||  |
tpsvnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

SYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNTYA
 .|| |  .  .. ... ||||||.  |||. .   .| ||.| |||| .  | |..| .| .|.  |.   
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqli
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 19-287 3e-80 262.7 In-house 6-279 (284) alignment 
Range on Protein: 19-287
Range on HMM: 6-279/284.0
EILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQC------PDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLL
..| |  . |.  . .||.  |.  .||..||..|||.|||| |.| .... |         ...||||||||||| .|.| |.|| ..||..| ...||
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRQITQVYGFYGECMRKYGNpTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDREGFVESQ
||||||| . . |||| || ..| . .... |   |  . ..|.... | |.|||.|   |...|.. |.|  ..|. | ..|. |.||. . ||. ||.
rgnhesrpvnmqygfyleckkryse.alyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNT
|||| ..|..   .||.. |.. ..||||. ||||. . |.|| |..||| || .  |.|....|.|.|.  |..
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 19-71 1.4e-09 30.6 In-house 7-59 (317) alignment 
Range on Protein: 19-71
Range on HMM: 7-59/317.0
EILPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGG
... |. . |.  . .||. .|    |...|||.|||.|||| |.| .... |
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
PPP_3 21-288 1.3e-114 374.8 In-house 2-269 (271) alignment 
Range on Protein: 21-288
Range on HMM: 2-269/271.0
LPESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQ
|.|...||...|.||.| .|||..||..||||.||.|||..|.||.||.||..|.|.|||||||||||..|.|.. || .||..||....||||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYGECMRKYGNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDREGFVESQRGAGYSYG
|..||||. |...|.|. .|.|...|.|..|..||.||| ...||||||||  |.|||| |.|..|||.||.| | |.|... ..||. .|.||||. .|
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

KDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNTY
.||| .||..||.. |||||.|...||..|.|.|. ||.||||||.|..|...|....|.|.. |...
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 22-295 1e-77 254.3 In-house 25-298 (299) alignment 
Range on Protein: 22-295
Range on HMM: 25-298/299.0
PESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQI
 |  .... .  |. ..|.. . |. .|. |.||.|||. |.| ||.. |  ||.|.||||||||||   .|.|.|| | |..|| |. .||||||   |
keqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpai

TQVYGFYGECMRKYGNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDREGFVESQRGAGYSYGK
 .||||| || ..|    .|  | . |... .. .|   | |.||||||   ..||.. | | |. ||     |.||.|||    ..    ||  | .|.
nrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvfgq

DVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNTYAAAPQSL
||    ... ... . ||||.  |||. . ..|| |..||| || .  | |.|..|.|.|   |  .  .|.||
dvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpksl
PP2Ac_SM00156 23-289 1.5e-106 348.4 In-house 3-268 (271) alignment 
Range on Protein: 23-289
Range on HMM: 3-268/271.0
ESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQIT
.. ..|. ...||.| .|.|. |. .|||||||.|||..|.|.... .|..|...|.|||||||||..|.|.|.||..||..||....||||||||....
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

QVYGFYGECMRKYgNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDREGFVESQRGAGYSYGKD
..|||. |..||| .  ... |.|.|..|..||..|. | |.||||||.  |.|.|. |.|..| |.|| | |.|||||. . .||  |.||... .|.|
kiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

VTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNTYA
.. .||..|....|||||.....||.. .|.|| |..||||||....|.|....|...|. ..... 
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlk
PPP_1 23-277 2.1e-106 348.0 In-house 3-264 (264) alignment 
Range on Protein: 23-277
Range on HMM: 3-264/264.0
ESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQIT
|....|. .|.|||| .|.|..|.....||.||.||||.|.|..||.||..|.|||||||||||||..|||.. ||..|||.||....||||||||||.|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

QVYGFYGECMRKYGNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDIL-------WSDPDPDREGFVESQRGA
.||||. |...|... ...|..|..||.|..||.||| |..|||||||.  ..|||. ..|..|||.||.|.| |       .||.. ..|.. .|.|||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEV
|| .||||| .|||.|... |||||.....||..|...|. |..||.||.....|....|..
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 23-287 4.4e-81 265.2 In-house 10-273 (281) alignment 
Range on Protein: 23-287
Range on HMM: 10-273/281.0
ESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQIT
.  |...  ... .. .|... || .|..||||.|.|| |. ..|.. |. |.. ..||||||||| .|.|.. || .||.||. || |||||||  .. 
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

QVYGFYGECMRKYGNpTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDREGFVESQRGAGYSYGKD
..|||| ||. |||   .|  | . |. | ..| |.. . |.||||||   ..|...   .  . .. | . |.||.|||.. |.. .| ||... .||.
kiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGkn

VTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNT
|     .. ... ||||||...|||..|   || ||.|.||||.   | |... |.|.|.  . .
vvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislva
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 23-71 4.6e-07 22.2 In-house 13-61 (339) alignment 
Range on Protein: 23-71
Range on HMM: 13-61/339.0
ESTIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGG
 . . |.  . .||. ||  . .. .|. |.||.|||| |.| .. . |
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 25-278 6.6e-52 169.6 In-house 10-287 (302) alignment 
Range on Protein: 25-278
Range on HMM: 10-287/302.0
TIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIG-----------GQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLR
 .  . ... |||  |... || .|||.|||.|||| |.. |..                    ..|||||||||..|.| |.|. .||. ||..  |||
ellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillr

GNHESRQITQVYGFYGECMRKYGNPT---VWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDR-FQEVPNEGALSDILWSDPD-------
||||.. |   ||| .|   ..|.     .|. | |.| .. .||.. | | |||||.||   |...|| ..| ..|| ..    |.|..||        
gnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaa

-PDREGFV-ESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVN
 ...  .. .  ||  ... .     . ..  .. |.||||    |..   |.|| |..|||.| |   |  ....|.
vsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 25-278 9.1e-52 169.1 In-house 11-288 (302) alignment 
Range on Protein: 25-278
Range on HMM: 11-288/302.0
TIKEITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIG-----------GQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLR
 .  . ... |||  |... || .|||.|||.|||| |.. |..                    ..|||||||||..|.| |.|. .||. ||..  |||
ellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillr

GNHESRQITQVYGFYGECMRKYGNPT---VWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDR-FQEVPNEGALSDILWSDPD-------
||||.. |   ||| .|   ..|.     .|. | |.| .. .||.. | | |||||.||   |...|| ..| ..|| ..    |.|..||        
gnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaa

-PDREGFV-ESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVN
 ...  .. .  ||  ... .     . .. ... |.||||    |..   |.|| |..|||.| |   |  ....|.
vsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
subfamily_PPPLV_pd Subfamily PPPLV 28-281 5.6e-58 189.5 In-house 4-280 (290) alignment 
Range on Protein: 28-281
Range on HMM: 4-280/290.0
EITDKMKELLISESNVQEIRSPVTVVGDVHGQFYDVL----EIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQITQ
 . |.  . |..| .. |..||. |.||.||.. |.      ....| .   ...|||||||||| .||| |. |  ||. |||.. ||||||| . ...
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

VYGFYGECMRKYGNP--TVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQI----KVLDRFQEvPNEGA--LSDILWSDPDPDR----------
 . ..||.. |.|.    ||. |...||.| .||.||. ..|||.|.  .. .  .|    ..|.|... . .||    |||||||. ||          
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkd.didgaplaldilwsdpaedrdlslrgelvl

-EGFVE-SQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKL
 ||||. ..|| |. ...|   .||..| .....|||.    |..   . .| ||.|. .||    . | |.  ..||
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvdkkkl
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 32-283 6.2e-64 209.1 In-house 31-284 (307) alignment 
Range on Protein: 32-283
Range on HMM: 31-284/307.0
KMKELLISESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQITQVYGFYGEC
. . .. ||  . .|  |. ||||.|||| |....| . |. |.| |.| |||||||  |.|.| || . |. ||  | |||||||  .. . |||| ||
eaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeec

MRK---YGNpTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDILWSDPDPDREGFVESQRGAGYSYGKDVTLRFL
.      |.  .|  |   |. | ..|.|   | |.||||||.   .|...   .    |  | . |.||.||||    .  | ||.|...| .|     
vtsipkcge.eiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvc

QNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLER
.   .. ||||||.|.|||  |   || |..||| |||   |   .. |.| |  
krlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgi
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 40-282 9.1e-66 215.2 In-house 22-265 (284) alignment 
Range on Protein: 40-282
Range on HMM: 22-265/284.0
ESNVQEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQITQVYGFYGECMRKYGNPT
.  . |. ||. ..||.|||| |.| .|   |    .|||||||||||| | .||| || . |. .| .. .||||||   | ..|||| || |.| .|.
qpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrrynkps

VWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALS-DILWSDPDPDREGFVESQRGAGYSYGKDVTLRFLQNNKMQHIIR
|.. |  .|  . ..|.. . | |.|||.|     . |.. . |  . |.  .|. |||||||   ..|.    ||  | .| |   ..|.  ... ..|
vyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrlqidlvvr

AHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLE
|||.  |||. . . .| |..||| || .  | |... ||..| 
ahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlv
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 44-285 7.6e-55 179.4 In-house 3-250 (263) alignment 
Range on Protein: 44-285
Range on HMM: 3-250/263.0
QEIRSPVTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQITQVYGFYGECMRKYGNP----T
 |...|. ..|| |||. |.| ||.  | .  |.||||||||||| ||.| | ||  |||  | .. ||||||| . | . |||. |  ...       .
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

VWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGAL-SDILWSDPDPDREGFVESQ-RGAGYSYGKDVTLRFLQNNKMQHII
|...| ..| |. ..||. . | |.|||.||   |.|.|. .    |  .   |  |.||.||. | .||   . |     .||     . .   .. |.
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidliv

RAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYF
||||.   ||  . | .| ||.||  |     | |..| ||. ||  |
rahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsf
Metallophos Calcineurin-like phosphoesterase 49-241 2.4e-43 141.7 Pfam-A 2-197 (200) alignment 
Range on Protein: 49-241
Range on HMM: 2-197/200.0
PVTVVGDVHGQFYDV----LEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLL--TCLKLRYPSRITLLRGNHESRQITQVYGFYGECM----------
...|.||.||...|     |...||..... ...|||||.|||| .| ||. ||   .|||..| .. ||||||||......|||. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNPTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSIDQIkvldrfqevpnegalsdilwsdpdpdregfv
                       ...... .. .. | |..|. .|..|  | ..||.||.|  | |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

esqrgAGYSYGKDVTLRFLQNNKMQHIIRAHQ
     ... .|.|..  .|.........|.|.
.....gselfgpdalekllekygvdlvlrGHt
PPP_2 50-242 1.9e-79 259.0 In-house 1-197 (198) alignment 
Range on Protein: 50-242
Range on HMM: 1-197/198.0
VTVVGDVHGQFYDVLEIFKIGGQCPDTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQITQVYGFYGECMRKYGNPTVWKYFTEMFD
|||.||.|||..|.|..|| |...|...|||||||||||..|.|.. ||..|||.||....||||||||.....||||. |...|.|. .|.|...|.|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVPNEGALSDIL----WSDPDPDREGFVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQL
.|..||.||| ...||||||..  ..||||  .|..|.|.||.| | |    .|||. ..|.. .|.||||. .|.||| ..|..||.. |||||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 50-242 1.4e-75 246.7 In-house 1-196 (197) alignment 
Range on Protein: 50-242
Range on HMM: 1-196/197.0
VTVVGDVHGQFYDV-LEIFKIGGQCP-DTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQITQVYGFYGECMRKyGNPTVWKYFTEM
||||||.|||..|. |...|.||. . ...|.|||||||||..|.|.. ||..|||.||....||||||||......|||. |...|  . ...|.....
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVP-NEGALSDI-LWSDPDPDREGFVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQL
||.|..||.||| ...||||||..  |.|.|. ..|..|.| .|... |. ||||| .. ||. .|.||||. .|.||| .||..|... |||.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 50-242 4.3e-74 241.8 In-house 1-198 (199) alignment 
Range on Protein: 50-242
Range on HMM: 1-198/199.0
VTVVGDVHGQFYDV-LEIFKIGGQCP-DTNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQITQVYGFYGECMRKYGNPTVWKYFTEM
|||.||.|||..|. |..|| ||. . ...|.|||||||||..|.|.. ||..|||.||....|||||||..|....|||. |...||..  ..|.....
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLSVAAIIDEAIYCVHGGLSPSALSIDQIKVLDRFQEVP-NEGALSDI-LWSDPDPDREG-FVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQL
||.|..||.||| ...|||||||.  ||.... ..|..|.| ..|  .|. ||||| .. || ...|.||||. .|.||| .||..|... |||.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 50-122 1.7e-08 27.3 In-house 12-80 (235) alignment 
Range on Protein: 50-122
Range on HMM: 12-80/235.0
VTVVGDVHGQFYDVLEIFK--IGGQCPDTNYLFLGDYVDRGYHSVETISLLtclklrYPSRITLLRGNHESRQIT
. ||||||| . ...|...  |||. ..   ...|| ...| .|||..|..        .    ..||||   . 
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 76-288 1.8e-74 243.7 In-house 101-312 (317) alignment 
Range on Protein: 76-288
Range on HMM: 101-312/317.0
TNYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQITQVYGFYGECMRKYGNpTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSI
 .||||||||||| .|.| ..||..|||.|| ...||||||||| . . |||| |. ..| . .... |  .|  | ..|.... | |.|||.| . |..
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQIKVLDRFQEVPNEGALSDILWSDPDPDREGFVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIV
.|...|.|  ..|. | |.|. |.|||.. .|. ||.|||| ..|..   .||.. ... ..||||. .|||. . | || |..|||.|| .  |.|...
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

EVNEKLERYFNTY
.|..||.  .|..
svdkklkisinvl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 77-289 5e-61 199.7 In-house 121-332 (339) alignment 
Range on Protein: 77-289
Range on HMM: 121-332/339.0
NYLFLGDYVDRGYHSVETISLLTCLKLRYPSRITLLRGNHESRQITQVYGFYGECMRKYGNpTVWKYFTEMFDYLSVAAIIDEAIYCVHGGLSPSALSID
 |||||||||||  |.| . |||.||| || || ||||||||| .   |||| |   .|    ... | .||. . ..|.|...| |.|||.|    |..
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIKVLDRFQEVPNEGALSDILWSDPDPDREGFVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVE
|. |. |  |.|. | |.|. |.||||  .|.  | ||| . .|      ||..  .| .|| ||.  |||. .   .| |..|||||| .  | |... 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

VNEKLERYFNTYA
...||.   | . 
idkklkisinvfr
subfamily_PPP7C_pd Subfamily PPP7C 194-292 3.6e-21 68.3 In-house 238-336 (383) alignment 
Range on Protein: 194-292
Range on HMM: 238-336/383.0
SDILWSDPDPDREGFVESQRGAGYSYGKDVTLRFLQNNKMQHIIRAHQLCMDGYQTLFDNKLSTVWSAPNYCNRCGNMASIVEVNEKLERYFNTYAAAP
 |||||||  ..  . .. ||.|  .| ||| ..||. ... .||.|.  ..||.   |.|. |..|| || .   |  . | ....|. ..  | |. 
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqask