Gene pppB in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP076_AA protein Get Run
DdisP076_AA_3-298 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPZ_pd Subfamily PPZ 3-299 3.9e-135 443.1 In-house 1-298 (300) alignment 
Range on Protein: 3-299
Range on HMM: 1-298/300.0
IDLDSIITRLLEP-RTTKPGKLVDLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETIC
.|.| || .||.   ..|  | | | ..||  . ..| |.|..|| ||||  ..|| ||.|||| ||||||   ||||..||||||||||||||||||| 
vdideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletil

LLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLL
|||.||||||||||.|||||||| . |.|||||||||| | |.||.| | || ||.|||.  ||||.|||||| |..||.||...||| ||||||. |||
lllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindll

WADPDKNIQGWEDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPADKKK
|.||  . . ||||.||||| .    .. ||.|  .||||||| |||||||||  | |||.|||||| ||||| ||.| | | |.|||..| | |   
wsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpldsaa
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 3-298 5e-129 422.8 In-house 1-297 (299) alignment 
Range on Protein: 3-298
Range on HMM: 1-297/299.0
IDLDSIITRLLEPRTTKPGKLVDLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICL
.|.| ....||.   ..      . |.|.. |   | ..|..|. |||.||||..|||||||| ||||.|.  ||||..|.||||||||||.| ||.|.|
ldvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitl

LLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNS-KLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLL
||..||||||.||.||||||| .|||.||||.||..||.| .|| .| |.|. .|.. .|  .|.|||||||| |...||.| .|||   |.  |  |||
llcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidll

WADPDKNIQGWEDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPADKK
|||||. ...|  | ||||| || |||.  ... |.|||.||||||.|||||||...|||.|||| | |.|||. |.| ||| |.|.|..|||..|.
wadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 4-298 3e-138 452.9 In-house 2-297 (298) alignment 
Range on Protein: 4-298
Range on HMM: 2-297/298.0
DLDSIITRLLEPRTTKPGKLVDLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLL
. |......|.  ...      . ||..  |  .|..|| .|. |.|..||||.|||||||| ||||||. .||||..||||||||||||.|.||.|.||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKIKYPENFFILRGNHECASINRIYGFYDECKRRY-NSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLW
||||.|||.|||.|||||||..|||.||||.|||||| . .|...| | || ||..|.| ..|.|||||||. ||..||.|...||.  ..  |  ||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

ADPDKNIQGWEDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPADKK
|||.....||..| ||||..||.|||. .|.| |.|||.|||||| |||||||...|||.||||.| |.|||. |.| ||| |..||..|||..|.
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
0049330 Metallo-dependent phosphatases 4-298 1.6e-114 375.1 In-house 8-302 (309) alignment 
Range on Protein: 4-298
Range on HMM: 8-302/309.0
DLDSIITRLLEPRTTKPGKLVDLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLL
.|...|..||.  . .. ||. | |||...|  .|.||....|.||||...| ..||||||..|||||.|  ||||  ...||||.|||| .|||...||
lllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevllll

LAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWA
||.|..||.|.|.||||||.. .|..|||.||..|.|...||..|.|....||.||.|..||.|.||||||||...||||.. ||. .|..||||||||.
lalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllws

DPDKNIQGWEDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPADKK
||.  . |. .|.||....||...||.||||..|||..|.|..|..||..|....|.|.|||||| |...|.||.. .||.|..||....|.. .
dplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 6-295 2.9e-108 354.6 In-house 3-295 (297) alignment 
Range on Protein: 6-295
Range on HMM: 3-295/297.0
DSIITRLLEPRTTKPGKLVDLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLA
||||  .|   | .      ..|| .  |   | ..| .|  ..|..||||.|||||||. ||||||  ||.|| .||||||||||||. |.||| ||||
dsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivllla

YKIKYPENFFILRGNHECASINRIYGFYDECKRRYNS-KLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSP---DLKNMDQIRRITRPTVVpDFGLLCDLL
||.|.| |.|.|||||||  .|..||||.||..||.| ... || | || ||.. .| .||.||||||||   .   .| .|.| |.|     .|..|||
ykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadll

WADPDKNIQGWEDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPA
||||   . |. .|.||    || | |     . .|||||||||||.||||||| |.|||.|||| | |.|||. |.| .|| | |||.||.|.
wadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
0053225 Metallo-dependent phosphatases 8-294 5.5e-105 343.8 In-house 4-290 (293) alignment 
Range on Protein: 8-294
Range on HMM: 4-290/293.0
IITRLLEPRTTKPGKLVDLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYK
.|..||.  .    .|. | |||...|  .|.||....|.||||...| ..|||||...|||.|.|. |||| ....||||.|||| .|||...||||.|
lilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalk

IKYPENFFILRGNHECASINRIYGFYDECKRRY-NSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPD
..||.|...||||||.. .| .|||.||..|.| ...||....|....||.||.|..||...|||||||| ..||||.| ||. .|..|||.|||| |||
llypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd

kNIQGWEDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKP
  . ||  . ||....||...|. ||||..|||..|.|||| |||... ...|||.|||||| |...|.||.. .|| |...|....|
.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_PPP1C_pd Subfamily PPP1C 18-297 7.9e-159 520.2 In-house 2-281 (282) alignment 
Range on Protein: 18-297
Range on HMM: 2-281/282.0
TKPGKLVDLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFIL
.|.|| |.| |.||..|. .| ||...||||||||||.||.|||||||.|||||||..|.||.||||||||||||||||||||.||||||||||||.|.|
skkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfll

RGNHECASINRIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDKNIQGWEDNDR
|||||.|||||||||||||||||..||||.|||.|||||.||..||||.|.||||||.||...|||.|.||. ||. ||||||||.||||...||..|||
rGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPADK
|||.|||.||||.||.|.||||..||||||||||||||||||||.|||||| ||||||||.. |||.|..||||||||.|
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 19-295 4.2e-85 278.3 In-house 9-289 (290) alignment 
Range on Protein: 19-295
Range on HMM: 9-289/290.0
KPGKLVDLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILR
| | |  .....|  .  .. ||.   | |||.|||| | ||||||  .||| |.  |.||. ..|||||||||| .|||   ||. |||.|...  .||
kygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllr

GNHECASINRIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVV--PDFGLLCDLLWADPDK-NIQGWE-D
||||.  .||.|||..|  |. .|.||| . | |. |.. | ...||.|||||.|....  . .. ...| |    | ||  |||||||..   .  . .
gnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialn

NDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPA
  |..|  || ......|||  |.|. |||.| |.|..|  ...|||.|||| | |.  | ||.. | |.|  |. .||| 
kqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
0045823 Metallo-dependent phosphatases 21-298 2.6e-116 382.0 In-house 38-327 (473) alignment 
Range on Protein: 21-298
Range on HMM: 38-327/473.0
GKLVDLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGN
 |.  | ||....|  .|.||. ..| ||||...| ..||||||..|||||.|  ||||  ...||||.|||| .|||...||||.|||||.|.|.||||
kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGN

HECASINRIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPdKNIQG--------W
||.. .| .|||.||. ..|. .|...| .....||.||.|..||...||||||||...||||.| ||  .||.|||.||||.||  .. |        .
HElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlrff

EDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQ------LVTLFSAPNYFGEFDNAGAMMGVDETLmCSFQILKPADKK
. . ||..|.||.|.|| ||||..|||..|.|..|..|||.. ...      ..|.|||||| |...| .|.. .||.| .||....|.. .
gnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphp
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 24-297 4.5e-100 327.5 In-house 6-279 (281) alignment 
Range on Protein: 24-297
Range on HMM: 6-279/281.0
VDLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHEC
|....|||  .  ..  || ..  | |...||.. ||.|.|. || ||||  | .|.  ..|||||||||.||||.. ||...||.|... ..|||||| 
vqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhei

ASINRIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDKNIQGWEDNDRGVSYTF
||.|.||||| ||. .|  .||  |  ||| ||..| |.... ||||||||.| ..|..| . .|   .| ||. ||||||||.. ..|    ||.|.||
asvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftf

GADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPADK
| .||.   |. ...|. |||||| |||| .. |.|.|.||.|||   . ||.|.. |||||  |.. | || .
GknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
subfamily_PPP2C_pd Subfamily PPP2C 25-298 8.2e-101 330.0 In-house 16-289 (290) alignment 
Range on Protein: 25-298
Range on HMM: 16-289/290.0
DLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECA
 | |.|.. |. .| ||. ..  . |...|. .|||.|||..||| ||  ||  |..||||||||||||  |.||..|| | |..|.|   |||||||  
qleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesr

SINRIYGFYDECKRRY-NSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDkNIQGWEDNDRGVSYTF
 | ..||||||| |.| |...|| ||| |..||..|..||.|||.|||||| .. .|.|| . |   ||. | ||||||.||| . .||   .||  |||
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagytf

GADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPADKK
| |. |.| |. .| |. ||||.| .||..  .|..||.||||||     | .|.. .|..|  ||   .|| ..
gkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 25-297 4.2e-98 320.8 In-house 9-284 (287) alignment 
Range on Protein: 25-297
Range on HMM: 9-284/287.0
DLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECA
 .....|  .  .. ||.   | |||.||||.|.||||||. ||||.|.  | .|. .||||||||||| .||| . ||...||.||..  .||||||. 
afsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevk

SINRIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDF--GLLCDLLWADPDKNIQGWEDND-RGVSY
 ||..|||..| ||.....|.| | | |. ||. |.....|.|||||.||.|| .|... ...||.  .   ||  |||||||.|. .. | |  |..| 
kinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisv

TFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPADK
 ||  .|...||| |.||. |||.|.|.||.|.....|||.|||| | ||  | ||.. |...|  ||  ||| | 
vfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
subfamily_PPP6C_pd Subfamily PPP6C 25-293 8.7e-92 300.3 In-house 14-282 (290) alignment 
Range on Protein: 25-293
Range on HMM: 14-282/290.0
DLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECA
 |.|.... |  . .......  .  ...|. .|||||||.|||. ||  ||  |...|.||||.||||  ||||. .||. |.|||..  .||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRY-NSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPdKNIQGWEDNDRGVSYTF
 | ..|||||||...| |.. || .|. |. |..||||||...|.|||||||.| .|||| |.| . .|  | .|||.|.|| .... |.  .||  | |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagylf

GADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILK
|. |...|..  .|.|.|||||.||.|.... . .|||..|||||     |  ... ....   .....|
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 25-296 1.8e-77 253.5 In-house 19-293 (307) alignment 
Range on Protein: 25-296
Range on HMM: 19-293/307.0
DLAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECA
. . ||.  .  .|  ||  .  |.... |  . ||.|||. ||. .|   | ||.. |.| |||||||  |||.| ||..||| ||||  .|||||| |
qytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheia

SINRIYGFYDECKR---RYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDKNIQGWEDNDRGVSY
 .|. ||||.||     .   ..|  |  ||| ||..|.|  ||.|||||||| |  .|..|   .|   |  |.. |.||||||  .  |    ||  .
rvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgf

TFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPAD
|||..|..   |.  ..|. ||||.. |||  .. |.|.|.|||| |   . |||... |||||      . |. 
tfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes
PPP_3 26-293 6.5e-114 372.5 In-house 2-270 (271) alignment 
Range on Protein: 26-293
Range on HMM: 2-270/271.0
LAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECAS
| |.|.. |. ...||. ....|.|..||...|||||||..|||.||..||..|...||||||||||||.|||...||||.|||||.....||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDKNIQGWEDNDRGVSYTFG
||..|||..|.. .....|..|.....|..||.||.||||....||||||..|..|||....|...||. |.|.|||. ..... .|.| ..||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

ADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILK
.||.|.||.|..|.|..|||...|.|||.......||.||||||.....||||.. ..|.|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 26-294 2.9e-110 361.2 In-house 8-282 (284) alignment 
Range on Protein: 26-294
Range on HMM: 8-282/284.0
LAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFP------PQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRG
| |.|.  | ..| |.| .... ||.|||.||.||||||. ||| |..  |.|       ...|||||||||||  |.| | ||.|||...|.. |.|||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDKNIQGWEDNDRGV
|||   .|. |||| |||.||  .|..||  .||..|..|....||.|||||.| || ...|. .. ||. .|| |...|| ||||.....|... .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKP
  .|||. |. ||||..|||| |||||| ||||||| |.|||.|||| | |..||..|.. ||| |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_PPP4C_pd Subfamily PPP4C 26-295 1.2e-100 329.5 In-house 16-285 (288) alignment 
Range on Protein: 26-295
Range on HMM: 16-285/288.0
LAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECAS
..|||.. |  .| ||....  . ....|. .|||||||.||||.||. ||  |. |||||||.||||. |.||. ||||.|..||..  ..|||||. .
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

INRIYGFYDECKRRYNS-KLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDkNIQGWEDNDRGVSYTFG
| ..||||||| |.| | ..|.  |. |. |..|||||.||||.||||||.....|.|| | | . ||. | ||||||.||. ...||    ||  | ||
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylfg

ADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPA
.||||.| .. |..|.|||||.| .|| .  .....|..|||||     |  |.. .||.|   |.|.. |
sdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
subfamily_PPP3C_pd Subfamily PPP3C 26-286 2.1e-89 293.4 In-house 41-314 (452) alignment 
Range on Protein: 26-286
Range on HMM: 41-314/452.0
LAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECAS
| ||..  .  .|.... ... |||.|||| ..||||||.||||.||| || | ...|||||||||||  |.|..  |.| ||.||...|.|||||||  
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

INRIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDKNIQGWE-------DNDRG
.   . | .||| .|. ....|....|..||.||..... .|.||||||..|..|.|... |   .| .|.||||||.|| .. .  .       .. ||
lteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrG

VSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAK------RQLVTLFSAPNYFGEFDNAGAMMGVDETLM
 || ..   | .||.| ||  . |||.. ..||. . |        |.|||||||| . ..| .|.. ...  |
csyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_PPG1_pd Subfamily PPG1 26-296 5.2e-84 275.0 In-house 14-297 (300) alignment 
Range on Protein: 26-296
Range on HMM: 14-297/300.0
LAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECAS
| |  .. || .  |.....  . |...|. . ||.|||.||.| .|. ||  |..||||||||||||  |.||| ||.. |..||    .||||||   
lpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrq

INRIYGFYDECKRRY--NSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDKN---------IQG--W
| ..|||| || |.|  ||..|| .|. |. | .||||||.|.|.||||||. . .|||. . |   ||. | |.||||.||..|          .|  .
itqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhf

EDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPAD
   .||  |..| |||| ||.. |.. . ||||.. .||. .   .| |..|||||     |  ... . | .   |.. . | 
vvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeap
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 26-80 3.2e-15 49.1 In-house 9-63 (317) alignment 
Range on Protein: 26-80
Range on HMM: 9-63/317.0
LAEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQ
. |.|.  |  .| |.| ..|. ||||||..|.||||||. ||| |..  |.|  
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpls
PP2Ac_SM00156 27-295 1.5e-116 381.1 In-house 2-270 (271) alignment 
Range on Protein: 27-295
Range on HMM: 2-270/271.0
AEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASI
..||.. |  .. ||. ... |.|..||. ..||||||..|||||.| .|.||...|.|||||||||.||.|.|.||.|.||.|||....||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDKNIQGWEDNDRGVSYTFGAD
|.||||..|.||.|...... |...|..||.||..|.||.||||||||.|...|.||...|.   |. |||.||||.||... .|.. . ||.|..||.|
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

VVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPA
.|. ||||..|.|..|||.||..||||||...|||.|||||| .||.|..|.. |...|..|.. ||..
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
PPP_1 27-280 3.9e-113 370.1 In-house 2-263 (264) alignment 
Range on Protein: 27-280
Range on HMM: 2-263/264.0
AEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASI
.|||.. |  ...|.. ....|||....|..|||||||..|||.||..||..|..|||||||||||||.|.|...||||.|.|||...|.||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECK-RRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLL-------WADPDKNIQGWEDNDRG
...|||..|.. ..|.....|..||.|..||.||.|||||...||||||.|. .||||...| |.||. | |||||       . |.... .......||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMG
..|.||.||.|.||.|..|.|..|||.|.|.||||..||..||.|||.||. |..|.||.. 
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 27-294 6.1e-69 225.5 In-house 7-299 (302) alignment 
Range on Protein: 27-294
Range on HMM: 7-299/302.0
AEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYG------------GFpPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENF
 ..|.  |  . .| . ..  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||.|.
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlyptny

FILRGNHECASINRIYGFYDECKRRYN----SKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTV-VPDFGLLCDLLWADPDK--
 .||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.|.|||.|| |. ...|..|.||   | .  |  |||.|||    
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

------NIQGW-EDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKP
      .   . ... ||.|..|    |. . |. .|.|. ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|..
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 27-293 1.4e-68 224.3 In-house 8-299 (302) alignment 
Range on Protein: 27-293
Range on HMM: 8-299/302.0
AEEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYG------------GFpPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENF
 ..|.  |  . .| . ..  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||.|.
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlyptny

FILRGNHECASINRIYGFYDECKRRYN----SKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTV-VPDFGLLCDLLWADPDK--
 .||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.|.|||.|| |. ...|..|.||   | .  |  |||.|||    
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

------NIQGW-EDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILK
      .   . ... ||.|..|    |. . |. .|.|. ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|.
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 28-295 2.8e-121 396.9 In-house 8-275 (280) alignment 
Range on Protein: 28-295
Range on HMM: 8-275/280.0
EEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASIN
| .|  .  . ..|.  |  ..|..||...|||.|||| ||||||.  .|||..||||||||||||.| || |.||||||..||.||.|||||||..|||
eadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisin

RIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDKNIQGWEDNDRGVSYTFGADV
| |||.||.||||. .|.. | . .. ||..|..  .|.|||||||..|. .|......||   .|  |  |||||||.... || .| ||||. |||.|
rkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganv

VESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPA
|  . .| |.||..| ||||.|||||||...|||.||||.| |||||. |.. ||| |. ||..||||
vkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 28-297 1.4e-109 359.0 In-house 5-276 (284) alignment 
Range on Protein: 28-297
Range on HMM: 5-276/284.0
EEEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASIN
 |..  | ..| .|| .||.|.| ..||.||||||||. ||||||.  ||| ..|||||||||||||. |||| ||.|||. .|. ||.|||||||. ||
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

RIYGFYDECKRRYNS-KLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFG-LLCDLLWADPDKNIQGWEDNDRGVSYTFGA
.|||||.||.||||   ....|   |  .|..|.. ..|.|||||.|  |.|. |.| | ||   |.   |  |.||.|| .  .||. | ||||| ||.
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgs

DVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPADK
| .  .| . ..||| ||||||.|||||||.|.|||.|||| | |.|||| |.| |.. |.||| .|.|  |
dalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 29-81 1.8e-10 33.4 In-house 14-66 (339) alignment 
Range on Protein: 29-81
Range on HMM: 14-66/339.0
EEIRYLTVQATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQS
 |.  |  .| |.   .||.|.||||| . ||||||. ||| ...  |.|  |
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwplss
subfamily_PPP5C_pd Subfamily PPP5C 34-283 2.3e-83 272.9 In-house 42-297 (322) alignment 
Range on Protein: 34-283
Range on HMM: 42-297/322.0
LTVQATEIFINQPILLELEAP----IKICGDIHGQYYDLLRLFEYGGFPPQS-NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINR
. ..|.|.. ..| |.|.. .    . .|||||||.|||| .||  | | ..  ||| ||.||||  |.|.| .||..|. ||..||. |||||  ..|.
illeakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnk

IYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGL-SPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDKNiQGWEDNDRGVSYTFGADV
.||| .|.| .|..|. . ||. || ||.| .|.||.. .|||| | |  ..|..|.| | .  |. |||..|||.||... .|     |||. .|| ||
lyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea.nGrspskrGvgvqfGpdv

VESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGV-DE
 . |||. .|.|. |.|.| |.|||.  . .|.|.||||||  . .| ||.. . ..
tkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgd
subfamily_PPPLV_pd Subfamily PPPLV 35-284 2.8e-57 187.2 In-house 6-278 (290) alignment 
Range on Protein: 35-284
Range on HMM: 6-278/290.0
TVQATEIFINQPILLELEAPIKICGDIHGQYYDLL----RLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIY
  .| .|....  ||||..|. . ||.||.| ||      |.  |     ...||||||||||. |.| |. ||| |. ||  ...||||||  |.   .
cdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesi

GFYDECKRRYNSKL---WKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITR-----PTVVPDFGLLCDLLWADPDKN-----------IQG
 .. |.. ..  .|   |.||...|. ||.||.||.|.||.|.|.    .   .|  |       .  .    |  |.||.||...            .|
eykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneG

WEDND-RGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAgAMMGVDET
. ||| || .. |..| .|.|||. .|. | |||.| | |...  | .|.|.||. .| |  ..| |.. ||. 
fvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssnea.alilvdkk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 37-295 8.6e-89 290.7 In-house 17-275 (280) alignment 
Range on Protein: 37-295
Range on HMM: 17-275/280.0
QATEIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDEC
    ||...  | | |||||. |||| || |. |||.  |  |. . .||||||||| | .| . ||.. ||.| .  ..||||||  |.|.||||| ||
mveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvec

KRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLLWADPDKNIQGWEDNDRGVSYTFGADVVESFLKKHD
. .|   ||  |  ||| .|....| ....||||||||.| |.| || | ||    | ||| ||||.|| .. .||  . ||.|| ||  |||   |  .
qykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksle

LDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPA
.||. ||||||.||||..| |.|.|.|| |||  .| || |.. ..  |  ||| | | 
idliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 48-296 8.9e-78 254.6 In-house 2-257 (263) alignment 
Range on Protein: 48-296
Range on HMM: 2-257/263.0
LLELEAPIKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNS-----
||||.|||.|||| |||| ||||.|.  |   ...||||||||||| .||| | ||.. |.  | ....||||||  .||. |||. | |.|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVV-PDFGLLCDLLWADPDKNIQGWEDND-RGVSYTFGADVVESFLKKHDLDLV
 ... | . |. .|..||. ..|.|||||.|| ||..|.|| |  |      . | ||||||||.|. .|.| |  | .|  ||   |. . |. |.||.
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSFQILKPAD
 ||||||| || ||| |.|.|.|||  |  |. |  |.. |.. |  ||  ||| |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
Metallophos Calcineurin-like phosphoesterase 54-246 2.4e-47 154.8 Pfam-A 2-198 (200) alignment 
Range on Protein: 54-246
Range on HMM: 2-198/200.0
PIKICGDIHGQYYDL----LRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLL--LAYKIKYPENFFILRGNHECASINRIYGFYDECK----------
.| ..||.||...||    |.|.. .. ..  ..|||||.||||. |.||..||  |..|...| ..| ||||||. ..|  |||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIrritrptvvpdfgllcdllwadpdkniqgwe
                         ... . . .. ..|..|| .|..| ||...||.||..... |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

dndrgVSYTFGADVVESFLKKHDLDLVCRAHQV
      |. || |..| .|.|...|||.|.|. 
.....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 54-189 4.5e-39 127.2 In-house 65-203 (383) alignment 
Range on Protein: 54-189
Range on HMM: 65-203/383.0
PIKICGDIHGQYYDLLRLFEYGGFPPQS-NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRY---NSKLWKAFT
 . .|||.||.  ||| ..   |.| .. .|.| ||.|||||.|.| ...|||. . ||..... |||||   .|  |||  | . .|   ..|. . . 
evtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlle

DCFNCLPVAAIIDEKIFCMHGGLSpDLKNMDQIRRITRPT
| |  ||.|..|||||. .|||.| |  ... . .| |  
dvfawlplatlidekilivhGGis.dktdlelldkiersk
PPP_2 55-246 1.7e-83 272.2 In-house 1-197 (198) alignment 
Range on Protein: 55-246
Range on HMM: 1-197/198.0
IKICGDIHGQYYDLLRLFEYGGFPPQSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECK-RRYNSKLWKAFTDCFN
...|||.|||..|||.||..|...|...||||||||||||.|||...||||.|..||.....||||||....|..|||..|.. .....|..|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVPDFGLLCDLL----WADPDKNIQGWEDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQV
.||.||.||||....|||||...|..|||....|....|. |.|.|||    . ||... .... . ||....||.||.|..|.|..|.|..|||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 55-246 2e-80 262.5 In-house 1-196 (197) alignment 
Range on Protein: 55-246
Range on HMM: 1-196/197.0
IKICGDIHGQYYDL-LRLFEYGGFPP-QSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNSKLWKAFTDCF
. ..||||||..|| |.|...||.|. ...|.||||||||||.|||...||||.|..||.....||||||..|.|..|||..|..........|...|.|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVP-DFGLLCDL-LWADPDKNIQGWEDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQV
..||.||.||||....|||||..|...|.|.||.|....| . ....|| ||.|| .. .|.... ||....||.||.|.||.|..|.|..|.|..
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 55-247 2.3e-76 249.2 In-house 1-199 (199) alignment 
Range on Protein: 55-247
Range on HMM: 1-199/199.0
IKICGDIHGQYYDL-LRLFEYGGFPP-QSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRR-YNSKLWKAFTDC
. .|||.|||..|| |.||. ||.|. . .|.||||||||||.|||...||||.|..||.....||||||. ..|.||||..|.... ...|..|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNCLPVAAIIDEKIFCMHGGLSPDLKNMDQIRRITRPTVVP-DFGLLCDL-LWADPDKNIQG-WEDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVV
|..||.||.||||....||||||..|.......|.|....| . |  .|| ||.|| .. .| .. . ||....|| ||.| ||.|..|.|..|.|...
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_YNL217W_pd Subfamily YNL217W 56-175 2.3e-08 26.8 In-house 13-139 (235) alignment 
Range on Protein: 56-175
Range on HMM: 13-139/235.0
KICGDIHGQYYDLLRLFE--YGGFPPQSNYLFLGDYVDRGKQSLETICLLlaykikYPENFFILRGNHECASIN------RIYGFYDE--CKR-RYN-SK
 . ||.|| | .|..|..   ||  ..   ...|| ...| .|.|.. ..        ..   ..|||| . .       .  |. .    ..  .  ||
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsflesk

LWKAFTDCFNCLPVA-AIIDEKIFCMHGGLSPD
| || ..    |. .  |  .... .|.||.| 
lskadmeyarelgfsldipsdellvvhaGlvpg
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 80-295 1.8e-97 319.4 In-house 100-315 (317) alignment 
Range on Protein: 80-295
Range on HMM: 100-315/317.0
QSNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNM
...|||||||||||  |.| . ||.|.|..||.. |.||||||  ..|. |||| |.|.||...|..||   ||.||..|....||.|||||.| .| ..
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQIRRITRPTVVPDFGLLCDLLWADPDKNIQGWEDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMM
.|. .. ||. .|| |.|.|| |||||....|...  || .  |||. |. ||||.||||| |||||||||||||| |.|||.||||.| |..||..|..
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

GVDETLMCSFQILKPA
 ||. |..|...|.| 
svdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 82-299 1e-75 248.0 In-house 121-338 (339) alignment 
Range on Protein: 82-299
Range on HMM: 121-338/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNSKLWKAFTDCFNCLPVAAIIDEKIFCMHGGLSPDLKNMDQ
 |||||||||||  |.| . || | |. ||.  ..||||||  |.|  |||| | . ||...|...| . || .|..|.|.. |.|||||.|  |  ..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRITRPTVVPDFGLLCDLLWADPDKNIQGWEDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGV
.  . ||  .|| |.| || |||||   .|..   || |. ||   . .|||| ||..| | |||||||||||  |.|||.|||||| |. ||. |.. .
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DETLMCSFQILKPADKKK
|. |  | ....|  . |
dkklkisinvfrpesrdk
subfamily_PPP7C_pd Subfamily PPP7C 197-289 1.7e-21 69.4 In-house 237-329 (383) alignment 
Range on Protein: 197-289
Range on HMM: 237-329/383.0
LCDLLWADPDKNIQGWEDNDRGVSYTFGADVVESFLKKHDLDLVCRAHQVVEDGYEFFAKRQLVTLFSAPNYFGEFDNAGAMMGVDETLMCSF
. |.||.|| ..   . .  ||    ||.|| ...|.|..|.|. |.|.   .||||  .....|.||| ||. |  | || . . ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri