Gene canA in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP078_AA protein Get Run
DdisP078_AA_130-334 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 63-520 8.4e-148 485.7 In-house 2-452 (473) alignment 
Range on Protein: 63-520
Range on HMM: 2-452/473.0
DRVVPSVKYPKSLPLPHDVLFNEDKTINLPKLQEHFFAEGRLNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFEnDIGGNPAnTN
|||...| .| . .| ...|| .   ..| .| ||.. ||.|. .|.......|.||| |||.|......|.|.|| |||..||....| .|| .|. ..
drvlklvlipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrlle.kigfppe.dr

YLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDI
..||||.||||..| ||. .|.| ||.||. .||||||||.|.|. .. |..|.|.||.|..|. . | ...|||||. .||.|..|||||||...||.|
lvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqi

ANIDRFKEPPSSGPMCDLLWSDPMEEFSP-EIREHFVPNDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNDATGFPSVITLFSAPNYL
..|.|. |.|..|...|||||||.|..    .|..| .|..||..||....||. ||.||.|  ..|.|...  ||...  . ..|....||.||||||.
reierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYc

DAYNNKGAVLRYENNVMNIRQFTCSPHPYWLPNFMDVFTWSMPFVSEKVAEMLLVLLNLCNDEEAEKNENAQtvkDTSEEEKRRQMLRAKVKSVSKMMRM
. ..|..|||..........|| .||||..||.|.|||..|.||..||..|.||.|||...|.| ...|.     ..   |.....|| |.. ..|..|.
grggnlaAvlvidedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddellededil...glllleallellrnkilalgkllrv

FSLLRQERETIMMIKSFSPSRKIPQGLLTEGKDALkkaLGDFAQARKMDLINEKRPPIL
||.||.|.|.....|...||. .|.|||..||..|   |.....|.|.||||||.|| |
fsvlreesesvlllkgltpsgllplgllllgkell...lesleealkldlineklppsl
subfamily_PPP3C_pd Subfamily PPP3C 64-518 2e-235 774.7 In-house 1-452 (452) alignment 
Range on Protein: 64-518
Range on HMM: 1-452/452.0
RVVPSVKYPKSLPLPHDVLFNEDKTINLPKLQEHFFAEGRLNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFEndIGGNPANTNY
||| .|..|||  | .. .|.|.....|  |.|||..||||.......|...||..|.||.||..|||||||.|| |||||||.|.||  .||.||.|.|
rvvkkvplpkskklteeevfdetgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfe..vgGdPastky

LFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIA
|||||||||||||.|...||||.||.||.|.|||||||||||||||||||||| .|||||||| ..|||..||||||.|..|||.||||||.||.|||| 
lflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddik

NIDRFKEPPSSGPMCDLLWSDPMEEFSPEI-REHFVPNDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNDATGFPSVITLFSAPNYLD
..|||||||.|||.||||||||.|... |  .|.||||.||||||.|||.|||.|||||.|||.|||||||.|||.|. ...||||||.|||||||||||
kldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyld

AYNNKGAVLRYENNVMNIRQFTCSPHPYWLPNFMDVFTWSMPFVSEKVAEMLLVLLNLCNDEEAEKNENAQtVKDTSEEEKRRQMLRAKVKSVSKMMRMF
.||||.|||.|||||||||||..|||||||||||||||||.|||.|||.|||. .||.|.|.|.||.|...  |..||.|||....|.|.....|..|.|
vynnkaavlkyennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnicsddelekeeeee.skeesesekrkevirnkiraigklarvf

SLLRQERETIMMIKSFSpSRKIPQGLLTEGKDALKKALGDFAQARKMDLINEKRPP
|.||.|.|.....|... ....|.|.|.|||..|...| .|..|.|.|||||| ||
svlreesesvlllkglt.tgalprgalsegkegleeklssfeeakkldlineklpp
0053225 Metallo-dependent phosphatases 89-380 2.6e-87 285.9 In-house 7-285 (293) alignment 
Range on Protein: 89-380
Range on HMM: 7-285/293.0
INLPKLQEHFFAEGRLNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFeNDIGGNPAnTNYLFLGDYVDRGYFSMEVIIYLYACKI
..| .| |...   .|. ....... .| ||| |||.|......|.|.|| ||...||.... ..|| .|. ....||||.||||..|.||. .|.|.|.
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlall.ekigfppe.drlvflGDlvdrGpdslevlelllalkl

NYPNTFFLLRGNHECRHLTEYFTFKEECLHKY-SEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPme
 ||. ..|||||||...|. .. |..|.|.|| ..|..| ... ...|||||| .||.|..|||||||. .||.|..|.|. ..|  |...|||||||  
lypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdp..

efspEIREHFVPNdVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQndatgfPSVITLFSAPNYLDAYNNKGAVLRYENN-VMNI
     ......|.  ||..... . ||. ||.||.|  .||.|...  ||... .      ....|.|||||||. ..|.|||| .... |...
....dlwsgwlps.yrglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgnlgavlaldeglvwgf
0049330 Metallo-dependent phosphatases 91-392 3e-94 308.6 In-house 17-305 (309) alignment 
Range on Protein: 91-392
Range on HMM: 17-305/309.0
LPKLQEHFFAEGRLNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFEnDIGGNPAnTNYLFLGDYVDRGYFSMEVIIYLYACKINY
| .| |... ...|. ....... .| ||| .||.|......|.|.|| |||..||....| .|| .|. ....||||.||||..| ||. .|.|.|. |
ldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrlle.kigfppe.drlvflGDlvdrGpdslevlllllalklly

PNTFFLLRGNHECRHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEefs
|. .||||||||.|.|. .. |..|.|.||..|... ... ...|||||. .||.||.|||||||...||.|....|. |.|  |..||||||||..   
pdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplp...

peIREHFVPNDvRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNDatgfpsVITLFSAPNYLDAYNNKGAVLRYENN-VMNIRQFTCSPHP
  |||.|.||. ||..... . ||..||.||.|  .||.|.|.  ||... ...      .||.||||||.. ..|.||||..... |.....| ..|..
..iregfapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvfsapnycgrlgnlgavleidedlvisfllfepvpll

YWL
..|
lll
subfamily_PPP5C_pd Subfamily PPP5C 93-391 2.9e-83 272.5 In-house 23-314 (322) alignment 
Range on Protein: 93-391
Range on HMM: 23-314/322.0
KLQEHFFAEGRLNHDDVIEIVKMAAEILEKEPTLIQVEAP----ITVCGDTHGQFYDLIKIFEndIGGNPAN-TNYLFLGDYVDRGYFSMEVIIYLYACK
.| |.| .. .|..  ...|...| |.|.|.|.|.... .    .|||||.|||||||. |||  . | |..   ||| ||.|||| ||.|||. |.. |
ellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnife..lnGlpseenpylfnGdfvdrGsfsveviltllgfk

INYPNTFFLLRGNHECRHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGL-SPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPM
. ||| ||| |||||  .. . . |..|. .||.|.|.|. ||.|| |||| ..| |.| .|||| | |  ||||. .|||...||..| ...|||||| 
llyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpq

EEFSpeirehfVPNDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRY--ENNVMNIRQFT
|.         . .  || .  .       ||..|.|  .||.|| .. ||... .       ..||.|||||| |  .||||...   ... .....|.
eanG.......rspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdG......klitvfsapnycdqmgnkgafitlrgddlklkfktfe

CSPHPYW
  .||  
avehpdv
subfamily_PPP7C_pd Subfamily PPP7C 93-269 1.2e-35 116.0 In-house 22-203 (383) alignment 
Range on Protein: 93-269
Range on HMM: 22-203/383.0
KLQEHFFAEGRLNHDDVIEIVKMAAEILEKEPTLIQVEA----PITVCGDTHGQFYDLIKIFENDigGNP-ANTNYLFLGDYVDRGYFSMEVIIYLYACK
|| |.|  . .|    |..|.. |...|.. | . .|..     .||||| ||.. ||. |.  .  | | .. .|.| ||.||||  |.|... |.|  
klieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilykn..GlpseenpyvfnGdfvdrGkesveillillall

INYPNTFFLLRGNHECRHLTEYFTFKEECLHKY---SEEVYDFITESFNALPLAALMNGKFLCIHGGLSpDIKTLDDIANIDRFK
. ||. ..| |||||   |   . |  |  .||   ....  .. . |  ||||.|.. | | .|||.| |.  |. . .|.| |
lvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_PPP2C_pd Subfamily PPP2C 96-387 8.5e-82 267.6 In-house 9-287 (290) alignment 
Range on Protein: 96-387
Range on HMM: 9-287/290.0
EHFFAEGRLNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFEndIGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFF
|..    .|. ..| |....| |||.||  . .|..|.||||| ||||.||...|   |||.  .||||||||||||||.|.| . .| | |. |..   
eklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfk..iggkspdtnylflgdyvdrgyysvetvtllvalkvrykerit

LLRGNHECRHLTEYFTFKEECLHKYSE-EVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEefspeiR
.|||||| | .|. . | .||| ||.. .|. ..|. |. |||.||.... .|.|||||| |.|||.| ..||..| |  ||.|||||||| .      |
ilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpdd......r

EHFVpNDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNDatgfpsVITLFSAPNYLDAYNNKGAVLRYENNVM-NIRQFTCSP
. ..    ||. | .      .| ..|.|  ..|||.    ||..  ...      |.|.||||||     |..|.|  ....  .. ||  .|
ggwg.isprgagytfgkdisekfnktngltliarahqlvmegynwshdrn......vvtifsapnycyrcgnqaailelddklkysflqfdpap
subfamily_PPP1C_pd Subfamily PPP1C 103-378 6.6e-89 290.8 In-house 9-270 (282) alignment 
Range on Protein: 103-378
Range on HMM: 9-270/282.0
RLNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFEndIGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHE
.|.. .. ...|.| ||| ..|.|...|||....|| |||..||...||  ..| |...|||||||||||| .|.|.|. | | ||.||...||||||||
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfe..tsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhe

CRHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEEfspeiREHFVPNDv
. ...... |..|| ..|| ...  .|. || ||||||.. | ||.||||||..| |..| .| |  | |..| .|||||||| .|     .. .  || 
sasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdke.....vlgwsend.

RGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYENNVM
|| |. .. ..| .|||||.|  ..|||.  ..||... ..       ..|.||||||.. ..|.||||. .....
rGvsftfgkdvvekflqkndldlivrahqvvedGyeffakr......qlvtvfsapnycgefdnagavlsvdeell
PPP_3 104-378 3.6e-98 320.9 In-house 2-263 (271) alignment 
Range on Protein: 104-378
Range on HMM: 2-263/271.0
LNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFenDIGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHEC
|..... |.||...||||||..|....||.|||||.|||..||...|  ..||....|.|||||||||||..|.||...|.|.||.||....|||||||.
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelf..knggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEs

RHLTEYFTFKEECL-HKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEEfspeirEHFVPNDV
|.......||.|.| .|....||. ..| |..||||||...|.|..||||||.||.||.| ...|..| |..|...|||.|...|.      |... |..
rqinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpek......eeglensk

RGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQndatgfPSVITLFSAPNYLDAYNNKGAVLRYENNVM
||...|.. .....||.||||  .|||||....||... .       .|.|.||||||.....|.||.|. |.. .
rGagllFgpdvteefleknkLkliiRaHelkeeGyeilhd......gkvvtvfSapnycerasnagailkleealt
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 104-378 1.4e-78 257.0 In-house 24-285 (298) alignment 
Range on Protein: 104-378
Range on HMM: 24-285/298.0
LNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFENdiGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHEC
....|| .....| .|..| ..|..|.|||.|||| |||. ||...|..  .| | ..|||||||||||| ...|||. | | |..||| ||||||||||
ikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdk..agfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhec

RHLTEYFTFKEECLHKY-SEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEEFSpeireHFVPNdV
 .. . . |.||| ..| | ..|    . ||||||.||. |. ||.|||||. .|.||..... | ......    ||||.|| .  .      . .|  
eainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavk.....gwaen.s

RGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYENNVM
|| |. .   .|  .|.| ..  |.|||   . ||..  ..       ..|.||||.|.. ..|  ||.. .....
rGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaek......klvtifsaphycgqfdnsaavmkvdeklv
subfamily_PPP6C_pd Subfamily PPP6C 104-377 2.9e-73 239.5 In-house 15-274 (290) alignment 
Range on Protein: 104-377
Range on HMM: 15-274/290.0
LNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFENdiGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHEC
|. .|. ..... ...| .| ..  |..|.||||| ||||||| ..| .  ||.  .|.|.||||.|||||.|.| . .| . |..||.   |||||||.
lpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrt..ggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhes

RHLTEYFTFKEECLHKYSE-EVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPmEEfspeIREHFVpnDV
|..|. . | .|||.|| . ... ..|. |. |..||..... ||.|||||||.||||.|  |.| .| |  |..|||.|||| |.    . .  |    
rqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.ed....vetwav..sp

RGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNDatgfpsVITLFSAPNYLDAYNNKGAVLRYENNV
||  ||.  . . .|.. |.|  ..|||.  . |.| ....       ..|..|||||     |  ..|. |.. 
rgagylfgskvtkefvhinnlklicrahqlveeglkymfdek......lvtvwsapnycyrcgnvasilaledae
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 104-381 1.9e-71 233.3 In-house 10-275 (287) alignment 
Range on Protein: 104-381
Range on HMM: 10-275/287.0
LNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFENdiGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHEC
.. .|..|... . ||||  |.|..||||||..||.|||. ||..||..   |......|||||||||||  |.||...|.. || ||.   |||||||.
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifna..vGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

RHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSS--GPMCDLLWSDPMEEfspeiREHFVPND
... . . ||||  .|..|..|    . |. ||| | .. . ||.|||.||..|.||..  . . . | .   | . ||||.|| ..      . | .| 
kkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.....aktfelnk

VRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYEnNVMNIR
.|. | ..  . | ..|.| ..  ..|||| .. ||.. ...       ..|.|||| |     | |||.  . ......
iraisvvfGkkevddllkkldidlivrahevseeGyaflfdk......rlvtvfsapyysgedtnlgavvvvs.kslels
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 104-378 6.2e-67 218.9 In-house 24-285 (299) alignment 
Range on Protein: 104-378
Range on HMM: 24-285/299.0
LNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFenDIGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHEC
.. .........| ... ....|..||||| |||| |||. ||..||  |. | | ..|.||||||||||   .|.|. |.. ||.||. ||.|||||||
vkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrif..dkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RHLTEYFTFKEECLHKY-SEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEEFspeirEHFVPNdV
  .   . | ||| ..| |  ..  . ..|.|.||. |.... ||.|||||| ..||| . .. | ..||.     ||||.|| .         . .| |
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsv.....kdwlan.v

RGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYENNVM
|| ||..    |   ... ..  | |||.  . ||..  ..       ..|.|||| |   ..|  |... ..|..
rgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffask......klvtifsaphycgqfdnsaaimkvdenlv
subfamily_PPZ_pd Subfamily PPZ 104-375 1.7e-65 214.5 In-house 25-282 (300) alignment 
Range on Protein: 104-375
Range on HMM: 25-282/300.0
LNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFENdiGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHEC
|. .....|.. | |..  .|.|...  .. . || |||. ||...| .   | |  .||||||||||||  |.| |. |.. ||.||. ||||||||||
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftk..cgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhec

RHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEefSPEIREhfvpNDVR
  .|  . | .|| ..   ...  . ..||.|||||.. || .|.|||||| ....|.|  . |  . |  | . ||||||| .  |..  |    .. |
anvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptd..ssnewe....dner

GCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHlqNDAtgfpSVITLFSAPNYLDAYNNKGAVLRYEN
| || |   |.  ||.|  .  | |||   . ||..   ||     |..|.||||||   ..| |||.   .
gvsycynkvainkflnkfgfdlvcrahmvvedgyeff..ndr....slvtvfsapnycgefdnwgavmsvse
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 104-378 4.5e-64 209.6 In-house 8-274 (284) alignment 
Range on Protein: 104-378
Range on HMM: 8-274/284.0
LNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFEndIGGNP------ANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLL
|.. ..||.   | |.. ||.  ...|||....|| |||| ||. ...  . | |       ...||||||||||| ||.|||  |.| |. .|.  |||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalld..lngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHECRHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEEFSpeirehF
||||| | .   . | .|| ..||| .|. .  .|||.||.|... | .|.|||.| |.  |... ...|  . |  | ..|| |.|| .| .       
rgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaeve......g

VPNDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYENNVM
  .  ||.  ..  .||  ||.| ||  |.|||.    ||..  ..       ..|.|||| |   ..| .|||. .....
ykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadr......klvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 104-375 2.9e-62 203.3 In-house 16-277 (290) alignment 
Range on Protein: 104-375
Range on HMM: 16-277/290.0
LNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFeNDIgGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHEC
.. .|..||.. . ||||  |.|..|||||.. || |||. .|.. | ... | | . ..||||||||||  |.|| ..|.  || |...  |||||||.
fsdkdileilekieeileplpalleveapivivgdihgqldallryf.dav.gyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhev

RHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPP--SSGPMCDLLWSDPMEEfspeIREHFVPND
|..   . ||||   | . ...    . |. |.| | .. | ||.|||.|..|.. . .  . . . |     | . ||||.|| ..      . .  | 
rkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrd....kddtialnk

VRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYEN
 |. | ..  ... ..|.|  |  ..|||| .. |... ...       ..|.|||| |     | ||...  .
qraisvvfgkkglddllkklalslivrahevkeegfnflfdk......klvtvfsapyysgndtnlgaiatvse
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 104-377 1.8e-59 194.4 In-house 6-290 (302) alignment 
Range on Protein: 104-377
Range on HMM: 6-290/302.0
LNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFENDIGGNPA---------NTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTF
... ... ....  | |.|| ||... .|.|. || |||| ||..|. . .  . |         .  ..|||||||||. |.| |  ..| |. ||. .
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FLLRGNHECRHLTEYFTFKEECLHKYSE----EVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSS-GPMCDLLWSDPMEE-
 |||||||.. .   ..|.||   ....    |...   | |  .|||||.  | ||.|||.|| ...|.|| .|.|  .  .      |||..||..  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

--FSPEIREHFVPNDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYENNV
   ... . ... | ||| |...   ||  . ..  |  ..|||    .|.|.. ..       ..|.||||.|..  .||||||. . | 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadk......klltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 104-377 2.6e-59 193.9 In-house 7-291 (302) alignment 
Range on Protein: 104-377
Range on HMM: 7-291/302.0
LNHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFENDIGGNPA---------NTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTF
... ... ....  | |.|| ||... .|.|. || |||| ||..|. . .  . |         .  ..|||||||||. |.| |  ..| |. ||. .
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FLLRGNHECRHLTEYFTFKEECLHKYSE----EVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSS-GPMCDLLWSDPMEE-
 |||||||.. .   ..|.||   ....    |...   | |  .|||||.  | ||.|||.|| ...|.|| .|.|  .  ..     |||..||..  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

--FSPEIREHFVPNDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYENNV
   ... . ... | ||| |...   ||  . .. .|  ..|||    .|.|.. ..       ..|.||||.|..  .||||||. . | 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadk......klltifsaprymnesdnkGavlkvdtng
PP2Ac_SM00156 105-378 8.4e-101 329.5 In-house 2-261 (271) alignment 
Range on Protein: 105-378
Range on HMM: 2-261/271.0
NHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFenDIGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECR
.. .|.|... ..|||..|..|..|.||.||.||.|||..||....  . .| |....|.|||||||||..|.|||..|.| || ||....|||||||..
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll..elageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEss

HLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPmeefsPEIREHFVPNDvRG
.......|.||. .||..|.|. ..| |..||||||.. |.||.||||||....||||....|.||.| .|...|||||||      .  ..| |.  ||
svnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp.....eqkekgfqpsk.rg

CSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYENNVM
.|.... .||. ||.||.|  .|||||... ||..  ..      ...|.||||||.|...||.|||..|.|..
lsvvFgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlk
subfamily_PPP4C_pd Subfamily PPP4C 105-378 1.6e-81 266.7 In-house 17-276 (288) alignment 
Range on Protein: 105-378
Range on HMM: 17-276/288.0
NHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFEndIGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECR
. ..| .. . | ||| .|  . .|..|.||||| |||||||...|.  .||.  .||||||||.||||..|.| .. | | |. ||.   |.|||||.|
keeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfk..vggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesr

HLTEYFTFKEECLHKY-SEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEEFSPEIrehfvpnDVR
..|. . | .|||.|| | .|. . || |. |.|||...|| .|.||||||.|.|||.|  ||| .| | .||.|||||||| .  .  .         |
qitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaegwav.......spr

GCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYENNVM
|  ||.  ..| .| ..|..  ..|||.    |||.|...      .|.|..|||||     |. |.|...... 
gagylfgsdvveqfneandielicrahqlvmegyklhfne......kvltvwsapnycyrcgnvaaileldeeld
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 105-376 1.7e-71 233.6 In-house 7-264 (280) alignment 
Range on Protein: 105-376
Range on HMM: 7-264/280.0
NHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFENDigGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECR
.. |. ....   .||  . |...|.||..|||| |||. ||...|..   . | ..|||||||||||| . .|||. | | |. |||.|..||||||. 
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarv..sfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevi

HLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEEFSPeirehfVPNDVRG
.. . . ||.|. ..||...|. . | .. |||.||..|. ||.|||||.....|||.|.. |  ... .    ||||.|| .. .         .. ||
sinrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtg......waensrg

CSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYENN
.|...    |  . .| ..  ..| |.  . ||..  ..       ..|.||||.||. ..|. |||. ...
vsvifganvvkdltekldidliarghqvvqdgyeffadk......klvtvfsapkylgefdnsaavlivder
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 105-151 1.5e-10 33.8 In-house 10-56 (317) alignment 
Range on Protein: 105-151
Range on HMM: 10-56/317.0
NHDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFE
.. ..||.   | |.. |||  ...|||.|..|| |||| ||. ...
kekelielcyrarelfwkeplkleleapvtivGdihGqfedllalld
PPP_1 106-370 1.3e-100 329.0 In-house 3-261 (264) alignment 
Range on Protein: 106-370
Range on HMM: 3-261/264.0
HDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFENdiGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRH
.. ..|..|...|.|.||..|..|...||||||.||||.||.|.|..  ||....|||||||||||||..|.|....|.| |..||...||||||||.|.
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkv..ggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrq

LTEYFTFKEECL-HKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEEFS-PEIREHFVPNDVR
.|....||.|.| .|||.|.|. .|..|. ||||||...|.|..||||||....||.| ...|..| |..|..||||..|  ...| .. .|..|.| .|
vtkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiR

GCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAV
|..||........|||||.| ..|||||....||... ..      .|.|.|||.|| .. .|.||.
GagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkr......kvvtifsasnyyeegsnrgay
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 106-379 6.7e-64 208.8 In-house 10-270 (281) alignment 
Range on Protein: 106-379
Range on HMM: 10-270/281.0
HDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFenDIGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRH
...........  |. .| .|.....||.| || |.|| ||...|  .. | .... ..|||||||||  |.||.| |.. || |..  .|||||||  .
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlf..ellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

LTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMeefsPEIREHFvpNDVRGC
.   . | .||  || ||..  . . || ||..||.. . ||.||||||.. .||.. |. .  ...  | . ||||.||     ..  | .  . .|| 
vnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpd....nkveewk..assrGs

SYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYENNV-MN
|...    |    .. ..  .||||    .||..           .||.||.||| . |.| .|||. .... ..
sftfGknvvddvckrleveliirahqvvqdGyevlsgr......klitvfsvpnycafyknaaavlkvdetlgis
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 106-377 1.5e-59 194.7 In-house 5-264 (284) alignment 
Range on Protein: 106-377
Range on HMM: 5-264/284.0
HDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFENDigGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRH
 .||  ..  | .|..|.| ||.|..|| .||| |||| ||...|...  | |  .||||||||||||   .| |. |.| |. .|| ||.|||||||  
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkn..gfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

LTEYFTFKEECLHKYSE-EVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDR-FKEPPSSGPMCDLLWSDPMEefspeIREHFVPNDvR
. . . | ||| ..| .  ||  .   |  .||.||.  . ||.|||.|  .. . ..  | | | .|       |.||||| .     ... . ||  |
inkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptn.....fqkgwnpns.r

GCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYENNV
| ||..   |.  .|.. ..  |.|||.  . ||..  .        ..|.|||| |   ..|  ||.  ..|.
gvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanr......rlvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 106-374 1.4e-58 191.6 In-house 25-282 (297) alignment 
Range on Protein: 106-374
Range on HMM: 25-282/297.0
HDDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFENdiGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRH
 . |.... .| ...... ....|.||| |||| |||| ||...|    || |  .|||||||||||| ||.| |. | | |...|  .|||||||||  
eervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhr..ggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

LTEYFTFKEECLHKY-SEEVYDFITESFNALPLAALMNGKFLCIHGGLSP---DIKTLDDIANIDRFKEPpSSGPMCDLLWSDPMEEFSPeirehFVPND
. . . | ||| ..| |  .|  . . || |||. |.  | ||.||||||   .  ||| . .|.| .|    . ..||||.||.  .|      |. |.
vnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsg.....fmenq

vRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYE
 ||.   .   ||     . ||  | |||.  . ||..           ..|.|||| |   ..|  |..  .
.rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagr......klvtifsaphycgqfdncaafmscd
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 107-387 1.2e-54 178.6 In-house 9-276 (280) alignment 
Range on Protein: 107-387
Range on HMM: 9-276/280.0
DDVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFEnDIGGNPaNTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHL
 ..| |..|   |. .|  |.. |||| | || | |. |. ..|.  ||  | . . .|||||||||   .||.| |.. || | .  .|||||||   .
heiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfd.ligrvp.eeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsv

TEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEEFspeirEHFVpNDVRGCS
 . . |  || .||   ..  .   || .|...|.. . ||.||||||..  || | || |  ||   | . ||||||| ..      | ..   .|| |
nkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkg.....egwf.hsirgis

YLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHlqndaTGFpSVITLFSAPNYLDAYNNKGAVLRYENNV-MNIRQFTCSP
|..    |    .  ..  .||||.  . ||.|      .|   .||.|| |||   . |  ||.  . |. ....|.   |
ymfgkgvveqacksleidliirahqvvqdgyemm.....agr.rlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp
subfamily_PPG1_pd Subfamily PPG1 108-374 7.7e-74 241.6 In-house 18-283 (300) alignment 
Range on Protein: 108-374
Range on HMM: 18-283/300.0
DVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFEndIGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLT
 | |...   |.| ||  .|....|.|| || ||||||...||.  |||.  .|||||||||||||..|.| |. | . |. ||    ||||||| | .|
tvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifk..iggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqit

EYFTFKEECLHKY--SEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPMEEFSPEI-----RE-HFVp
. . |  |||.||     |....|| |. | |||... .  |.||||||.....|.|  .|||.| |  | ..||||||| |. .| .        ||| 
qvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfv.

NDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNDatgfpsVITLFSAPNYLDAYNNKGAVLRYE
.  ||. | |    |  ||..|..  .||||.  | ||.....|       . |..|||||     || ..|  .
vsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnk......lstvwsapnycyrcgnkasilely
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 108-151 6.4e-08 25.0 In-house 15-58 (339) alignment 
Range on Protein: 108-151
Range on HMM: 15-58/339.0
DVIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFE
.. |... | |..  || ....|||| | || |||| ||. ...
elaelchrareliwsepiflkleapicvmgdihgqfddllamld
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 109-376 9.2e-50 162.5 In-house 25-281 (307) alignment 
Range on Protein: 109-376
Range on HMM: 25-281/307.0
VIEIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIKIFEndIGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLTE
. ...  |  |.  | .|.... |  | || |||| |||..|   . | | .| |.| ||||||| .|.|.|. |.. || ||.   |||||||  .. .
fenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfi..llgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnk

YFTFKEECL---HKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLWSDPmeefSPEIREHFvpNDVRGC
 ..| |||.    |  ||.. ..   || ||..||.  | ||.|||||| .  ||.. |  .    |  | . |.||.||     | . |       || 
kygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadp....dpsvfewk..assrgs

SYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHlqndaTGfPSVITLFSAPNYLDAYNNKGAVLRYENN
 . .    .    ..  .  .||||.    || .      .|   .||.|||| | . |.| |.||. .. 
gftfgtnviddvckrlgveliirahqmcfdgywvl.....sg.rklitifsapmycnfyknagcvlkvdet
subfamily_PPPLV_pd Subfamily PPPLV 111-378 3.7e-58 190.1 In-house 4-280 (290) alignment 
Range on Protein: 111-378
Range on HMM: 4-280/290.0
EIVKMAAEILEKEPTLIQVEAPITVCGDTHGQFYDLIkIFEND---IGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLT
 . ..| .|| .|  |.....|. | || ||.. ||| .||.    .| . . ...|||||||||| ||.|.| ||.| |. ||  ..||||||| . ..
slcdvavdilaaeerllelksptyvlgdlhgnyrdli.yfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

EYFTFKEECLHKYS---EEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANI----DRFKEPPSSGPMC-DLLWSDPMEEFSPEIR-----
| ...| |. .|.    |||.. ... |.|||||| .. | .|.|.|.   |.|   |. |    .|.|..    |.  |.||||| |.    .|     
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

-EHFVPNDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKmhLQNDAtgfpSVITLFSAPNYLDAYNNKGAVLrYENNVM
 | ||.|| || ....|  |. .||..| |  |.||||....|..  ||...     ..|.||. .|  . |.   .|  ... .
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGir..lqqkg....rlltvfsssrycGssneaalil.vdkkkl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 126-372 5.3e-50 163.5 In-house 2-241 (263) alignment 
Range on Protein: 126-372
Range on HMM: 2-241/263.0
LIQVEAPITVCGDTHGQFYDLIKIFENdiGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLTEYFTFKEECLHKYS-EEV
|....||| .|||||||. ||..||.    |  ..|.||||||||||| .|.|||. |.. |.  |  ..||||||| . . . . |. |  ...  |||
llelqapinicgdthgqyndllrifna..cgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreev

YDFITE----SFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPM-CDLLWSDPMEEfspeiREHFVPNDVRGCSYLYSYRAVCSFLQ
|. . .     |. .||.|... . ||.|||.|| .|.||||  |    |   . |. |||||.|| ..      . | || .|  | ..  . |  . .
yesvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekd.....akgfepnkiraisnvfgkkevddlck

KNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLR
.  .  ..|||.  . || .  .        .||.|||  |     |  ||. 
rldidlivrahqvveygyaffadr......rlitvfsasryqielcnyaavvv
Metallophos Calcineurin-like phosphoesterase 132-333 5.4e-43 140.6 Pfam-A 2-199 (200) alignment 
Range on Protein: 132-333
Range on HMM: 2-199/200.0
PITVCGDTHGQFYDL--IKIFENDIGGNPANTNYLFLGDYVDRGYFSMEVIIYL--YACKINYPNTFFLLRGNHECRHLTEYFTFKEECL----------
.|.|.||.||...||  .    ..|.... ....|||||.||||  | |.. .|  .. |...|. .||||||||........ |..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------HKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDDIanidrfkeppssgpmcdllwsdpmeefspei
                        ...  ...... | |.||||.|| .||.|..||.||.. .. |||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

rehfvpndvrgCSYLYSYRAVCSFLQKNKLLSVIRAHEAQ
           .|.|....|.. .|.|...  |.|.|. .
...........gselfgpdalekllekygvdlvlrGHtHk
PPP_4 133-333 1.3e-74 243.5 In-house 1-197 (197) alignment 
Range on Protein: 133-333
Range on HMM: 1-197/197.0
ITVCGDTHGQFYDLIKIFENdIGGNPA-NTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLTEYFTFKEECLHKYSEEVYDFITES
.||.||.|||..||. .. . .||.|. ...|.|||||||||..|.||...|.|.|..||....|||||||...|.....||.|.|.|...|... ....
vtvvGDiHGqlddlllkllk.ngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdv

FNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPP-SSGPMCDL-LWSDPMeefspEIREHfVPNDVRGCSYLYSYRAVCSFLQKNKLLSVIRA
|. ||||||...|.|..|||||.....||.| .|.|..| | ... ..|| |||||.     |  |. . | |||...|........||.||.| ..||.
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr.....eaqeg.lansvrGagllFgpdvtekfleknnlkliirs

HEAQ
||..
helk
PPP_2 133-332 1.5e-72 236.5 In-house 1-197 (198) alignment 
Range on Protein: 133-332
Range on HMM: 1-197/198.0
ITVCGDTHGQFYDLIKIFenDIGGNPANTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLTEYFTFKEECL-HKYSEEVYDFITES
.|||||.|||..||...|  . |.......|||||||||||..|.||...|.|.|..||....|||||||.........||.|.| .|....||. ..| 
vtvcGDlHGqldDLlilf..knglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqev

FNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPPSSGPMCDLLwsdPME-EFSPEIREHFVPNDVRGCSYLYSYRAVCSFLQKNKLLSVIRAH
|..||||||...|.|..|||||..||.||.| ...|..| |..|...|||   ..|   .|. .|... |..||...|.. ......|.||||  .||||
felLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll...eeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaH

EA
|.
ev
PPP_5_Dcr2 133-332 7.8e-72 234.4 In-house 1-198 (199) alignment 
Range on Protein: 133-332
Range on HMM: 1-198/199.0
ITVCGDTHGQFYDLIKIFENDIgGNPA-NTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLTEYFTFKEECLHK-YSEEVYDFITE
.|||||.|||..||. |..... |.|. ...|.|||||||||..|.||...|.|.|..||....|||||||...|.|...|..|.|.| .....|. ...
vtvcGDlHGqlddlllilfkeg.gdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsd

SFNALPLAALMNGKFLCIHGGLSPDIKTLDDIANIDRFKEPP-SSGPMCDL-LWSDPMeefsPEIREHFVPnDVRGCSYLYSYRAVCSFLQKNKLLSVIR
.|. ||||||...|.|..||||||.||.......|.|..| | ..| ..|| |||||.    ..  . ...  .||...|....... ||.||.|  .||
vfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr....daqegckln.seRGagllfgpdvtekfleknnlkliir

AHEA
.||.
shel
subfamily_YNL217W_pd Subfamily YNL217W 133-217 1.1e-08 27.9 In-house 12-90 (235) alignment 
Range on Protein: 133-217
Range on HMM: 12-90/235.0
ITVCGDTHGQFYDLIKIFENDIGGNPANTNYLFLGDYVDRGYFSMEVIIYLyackinYPNTFFLLRGNHECRHLTEYFTFKEECL
. | || || . .||..... |||   |   ...|| ...|  |.||. |.        .    ..||||   | .|   |.. .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkg
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 160-377 5.3e-55 179.8 In-house 100-305 (317) alignment 
Range on Protein: 160-377
Range on HMM: 100-305/317.0
NTNYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTL
. .||||||||||| ||.||.| |.| |. ||.  |||||||| | .   . | .|. ..||...|.     ||.|||.|..| | ||.|||.| ..  |
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DDIANIDRFKEPPSSGPMCDLLWSDPMEEfspeirEHFVPNDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPN
. . ...|  . |  | ..|| |.|| .|      ..   .  || . ..  .||  ||.| .|  |.|||.  . ||..  .        ..|.||||.
kqldklkrpldipdvGvladltwadpdae......vkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadr......klvtifsaps

YLDAYNNKGAVLRYENNV
|    .| .|||. ....
ycGqldniaavlsvdkkl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 162-375 4.2e-44 144.0 In-house 121-322 (339) alignment 
Range on Protein: 162-375
Range on HMM: 121-322/339.0
NYLFLGDYVDRGYFSMEVIIYLYACKINYPNTFFLLRGNHECRHLTEYFTFKEECLHKYSEEVYDFITESFNALPLAALMNGKFLCIHGGLSPDIKTLDD
 ||||||||||| |||||.| | | |. ||.  .||||||| | .   . |  |  ..|  ..|. . . || .|..|..|   .|.|||.|  . ....
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IANIDRFKEPPSSGPMCDLLWSDPmeefSPeIREHFVPnDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHlqnDATgfpSVITLFSAPNYL
.. . |  | |  | . || |.||     |   . . |   ||.|...   |. .||.|  |  ||| |.  . ||..    |      ..|.|||||| 
fsvfkrpleipdvgvltdltwadp....dp.tekgykp.sargasfvfgppalraflkkldlqmvirghqvvedgyeff...dgr...rlvtifsapnyc

DAYNNKGAVLRYEN
   .|  ||.  ..
gqndntaavfsidk
subfamily_PPP7C_pd Subfamily PPP7C 277-378 1.1e-13 43.7 In-house 237-326 (383) alignment 
Range on Protein: 277-378
Range on HMM: 237-326/383.0
MCDLLWSDPMEEfspeirEHFVPNDVRGCSYLYSYRAVCSFLQKNKLLSVIRAHEAQNAGYKMHLQNdatgfpSVITLFSAPNYLDAYNNKGAVLRYENN
. |.|||||...      |  .|| .||    .      ..||| .|  .||.|| .  ||..  ..       |.|.||| || .   |.|| ..  ..
vldilwsdpkak......eGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdk......kvltifsasnyyeeGsnrGayvklgkd

VM
..
lt
Med3 Mediator complex subunit 3 fungal 509-610 7.1e-07 15.0 Pfam-A 247-348 (379) alignment 
Range on Protein: 509-610
Range on HMM: 247-348/379.0
MDLINEKRPP--ILDRVNSRGELLRMNSRGElfrINSKGDLFRSNSYAdLKPPQGPQETI--KITECHEQnITTNNINPNSITTNE-NNSNEQLQQQQQQ
|.|.|.. |   .   .|  .   ..|. |.    |  |..  |.     .. ..... .  ..|  ... .  ||| | .|   . |. ... ||||.|
mqllnqvaPnnamasPlNnmspmrnlnqmGn...qnnggqmnnsannG.nmnnmskennlnanmtpsksm.lnlnniTPaniLsmslnldfdlqqqqqpq

QQQQQPP
|.|.|. 
qaqsqnq