Gene ppp5C in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP5C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP080_AA protein Get Run
DdisP080_AA_191-510 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
TPR_11 TPR repeat 51-116 7e-16 47.3 Pfam-A 2-69 (69) alignment 
Range on Protein: 51-116
Range on HMM: 2-69/69.0
KSDEYKAIANKHFSEQKYDLAAEVYTKAIKYHP-TAILYSNRSFSNFKN-ELYVNALQDAQTSHEMDP
.....|. .|..|.|..|| | | |.||... | .|.||.|.. . .|. . |. ||.|.. ..| ||
nAealkelGnalfkegdydeAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_1 Tetratricopeptide repeat 53-84 2.6e-06 16.6 Pfam-A 2-33 (34) alignment 
Range on Protein: 53-84
Range on HMM: 2-33/34.0
DEYKAIANKHFSEQKYDLAAEVYTKAIKYHPT
. .. ..| ... .||| | | | ||..  |.
kalynlGnaylklgkydeAleyyekALelnPn
TPR_2 Tetratricopeptide repeat 54-84 6.9e-06 15.5 Pfam-A 3-33 (34) alignment 
Range on Protein: 54-84
Range on HMM: 3-33/34.0
EYKAIANKHFSEQKYDLAAEVYTKAIKYHPT
 . .... ..  ..|. |.| . ||... |.
alynlGlayyklgdyeeAleafekAleldPn
TPR_12 Tetratricopeptide repeat 99-147 6.3e-07 18.7 Pfam-A 26-74 (78) alignment 
Range on Protein: 99-147
Range on HMM: 26-74/78.0
ELYVNALQDAQTSHEMDPTYIKAYYRLGSAHLALRNFEEAKHFFKELLT
|||  ||. ... .. .| . .|.. |. ..||| ...||. .... |.
elyekalellrelgddhpdtaralnnlanlylalgdydeAleylekAle
TPR_19 Tetratricopeptide repeat 101-151 6.2e-07 18.7 Pfam-A 7-57 (68) alignment 
Range on Protein: 101-151
Range on HMM: 7-57/68.0
YVNALQDAQTSHEMDPTYIKAYYRLGSAHLALRNFEEAKHFFKELLTKNPK
| .||.  .   . || .  |...|. |.||| ...||.  ...|. ..|.
yaeAlkllkqalqedpqnaearllLAeallalgqldeAealLdtlplqdpd
TPR_2 Tetratricopeptide repeat 120-151 1.4e-09 27.0 Pfam-A 2-33 (34) alignment 
Range on Protein: 120-151
Range on HMM: 2-33/34.0
KAYYRLGSAHLALRNFEEAKHFFKELLTKNPK
.|.|.|| |...|...|||...|.. |  .|.
ealynlGlayyklgdyeeAleafekAleldPn
TPR_1 Tetratricopeptide repeat 120-151 9.3e-09 24.3 Pfam-A 2-33 (34) alignment 
Range on Protein: 120-151
Range on HMM: 2-33/34.0
KAYYRLGSAHLALRNFEEAKHFFKELLTKNPK
||.|.|| |.| | ...||  .... |. ||.
kalynlGnaylklgkydeAleyyekALelnPn
TPR_8 Tetratricopeptide repeat 120-150 5.3e-07 18.7 Pfam-A 2-32 (34) alignment 
Range on Protein: 120-150
Range on HMM: 2-32/34.0
KAYYRLGSAHLALRNFEEAKHFFKELLTKNP
||||.||...  | ....|| .... |  .|
kayynlGdiYrqlGdydkAkeylekalelkp
TPR_14 Tetratricopeptide repeat 120-157 2.2e-06 17.7 Pfam-A 2-39 (44) alignment 
Range on Protein: 120-157
Range on HMM: 2-39/44.0
KAYYRLGSAHLALRNFEEAKHFFKELLTKNPKENDAKI
.|...|. |.||| ...||   ....| ..|.. .| .
eallalarallalGdpdeAiallrralalaPddaeall
TPR_11 TPR repeat 120-175 4.3e-06 15.9 Pfam-A 4-58 (69) alignment 
Range on Protein: 120-175
Range on HMM: 4-58/69.0
KAYYRLGSAHLALRNFEEAKHFFKELLTKNPKenDAKIKLNLCNNLIKA-KLFEDAI
.|...|| |.. .....||  .... |  .|.  .|.. .||.  ..|  | .|.|.
ealkelGnalfkegdydeAieayekAleldpn..naelyynlAlaylklgkdyeeAl
TPR_6 Tetratricopeptide repeat 121-151 3e-06 16.6 Pfam-A 2-32 (33) alignment 
Range on Protein: 121-151
Range on HMM: 2-32/33.0
AYYRLGSAHLALRNFEEAKHFFKELLTKNPK
|.|.|. ....| ...||.  ...|... |.
AlyklalsyyklgdtdeAlealerlikeyPd
TPR_16 Tetratricopeptide repeat 123-162 4.2e-06 17.0 Pfam-A 1-40 (65) alignment 
Range on Protein: 123-162
Range on HMM: 1-40/65.0
YRLGSAHLALRNFEEAKHFFKELLTKNPKENDAKIKLNLC
..|. | |......|| . ....| ..|.  .|.  |  .
lalArallraGdydeAlaaleaalalaPeaaeallllaea
TPR_19 Tetratricopeptide repeat 134-174 6.9e-06 15.4 Pfam-A 6-44 (68) alignment 
Range on Protein: 134-174
Range on HMM: 6-44/68.0
NFEEAKHFFKELLTKNPKenDAKIKLNLCNNLIKAKLFEDA
...||  ..|..|  .|.  .| ..|.|.. |.... ...|
dyaeAlkllkqalqedpq..naearllLAeallalgqldeA
PPP5 PPP5 TPR repeat region 158-250 1.1e-28 89.5 Pfam-A 1-95 (95) alignment 
Range on Protein: 158-250
Range on HMM: 1-95/95.0
KLNLCNNLIKAKLFEDAILI--TPESYFKELDINSMNVEESYKGPKFESEKITIEFVNEMIEWMKGQKSVHKKYVCKILKQSFEMMKELPTLVDI
||. |. |.| . || || .   ..|. ...||.|...|..|.||..| ||.|.|||.|..|..| || .|||.|..|| .  |..|.||.||.|
KlkeCeklvkkiaFekAIevdeekrsvaesidiesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpslvei
0045823 Metallo-dependent phosphatases 192-510 1.3e-98 323.7 In-house 11-335 (473) alignment 
Range on Protein: 192-510
Range on HMM: 11-335/473.0
NVEESYKGPKFESEKiTIEFVNEMIEWMKGQKSVHKKYVCKILKQSFEMMKELPTLVDIDHdttmNITICGDTHGQFYDLLNIFKINGSPSEeKPYLFNG
.|  .. .|..  .. .. .....||..| .. .......|.|..  |..|. |.|....     .|...|| |||..|||......| |.|   ..|.|
pvlrlltlpllfill.glldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drlvflG

DFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFGKDgVTLDDIRKIK
|.||||..| |..  |||.|..||....| |||||.  .|  ||| .|. .||.| ... | |.... ||| |... . .|||||.     .||.||.|.
DlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdl.plldqireie

RNApDPKDNELVQCLLWSDPQSNPG--------IAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGS------LITVFSAPNYCDQS
|   .. |. |.  ||||||..  |        . .| ||.|..||||....|||.|.| .|.|.|.. . ||..  ||.      .||||||||||.. 
rpl.eipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrg

GNLGSFINITEDKIKITTFEAVEHPNIPPMHYA
|||.... |.||.|....|....||.| |... 
gnlaAvlvidedlisfiqfdpsphplilplfld
subfamily_PPP5C_pd Subfamily PPP5C 193-511 6e-171 560.7 In-house 2-321 (322) alignment 
Range on Protein: 193-511
Range on HMM: 2-321/322.0
VEESYKGPKFESEKITIEFVNEMIEWMKGQKSVHKKYVCKILKQSFEMMKELPTLVDIDHDTTMNITICGDTHGQFYDLLNIFKINGSPSEEKPYLFNGD
||.||.|||.|.||||.|||.|..|..| ||..||||..|||... |..|.||.||.|....|...|.|||.|||||||||||..||.||||.|||||||
vedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGd

FVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFGKDGVTLDDIRKIKR
||||||||.|.|.|||..|||||||..|.|||||...||..|||.||| |||.|.|.|||.|.|||.||| |..|...||||||| .|||||||.|||.|
fvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidr

NAPDPKDNELVQcLLWSDPQSNPGIAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINI--TEDK
|| .|....||. |||||||...|..||.|||||.||||||..|||||||..|||||||||.||....||.|||||||||||||.||.|.||..  ...|
naqppeegllve.llwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlk

IKITTFEAVEHPNIPPMHYAK
.|..||||||||...||.||.
lkfktfeavehpdvkpmayan
subfamily_PPP7C_pd Subfamily PPP7C 193-393 3e-60 197.0 In-house 2-202 (383) alignment 
Range on Protein: 193-393
Range on HMM: 2-202/383.0
VEESYKGPKFESeKITIEFVNEMIEWMKGQKSVHKKYVCKILKQSFEMMKELPTLVDIDHDTTMNITICGDTHGQFYDLLNIFKINGSPSEEKPYLFNGD
||.||.||...   .| . |...|| .| .| .| ||| .||... ...|.|| .  .   .. ..|.||| ||.. ||| |.  || ||||.||.||||
vedsytgprlsl.pltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

FVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKY---SEMVFDLFSELFNWFPLAFVLDESFMVVHGGLfgKDGVTLDDIRK
|||||. | ||.. |||. |.||....| |||||   .|  |||  ||  ||   .. .  |. ..| |.||| ..||. ..||||.   |   |. . |
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGi..sdktdlelldk

IKRN
|.|.
iers
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 204-493 1.3e-72 237.3 In-house 3-286 (298) alignment 
Range on Protein: 204-493
Range on HMM: 3-286/298.0
SEKITIEFVNEMIEWMKGQKSVHKKYVCKILKQSFEMMKELPTLVDIDHdttmNITICGDTHGQFYDLLNIFKINGSPSEeKPYLFNGDFVDRGSFSFEI
.... ||...  ..  |. |..... | |..... ...|. ..||..|      |..||| |||. ||| .|. .| | . . ||| ||.||||....|.
vdellievlsvslsekkltkvikeedveklielakkifkkqkslvevda....pikvcGdihGqysdllrlfdkagfppd.anylflGdyvdrGrqnlev

IITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKY-SEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFgKDGVTLDDIRKIKRNApDPKDNEL
|. |||||. |||.. | |||||.. .|| |||. |.  .| |  ..  | ..||..||. .. .  . .||||  |  ..||..|..||   |.|.. |
ivlllaykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGls.kklksldqlrelkrpf.dskeesl

VQCLLWSDPQS-NPGIAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEdKIKI
.  |||.||..   | |..||||.| || || . .|.. ..  ..|.| |   ||.   .  |.|.||||.||.|  |  ..... | |...
aidllwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvde.klvv
0049330 Metallo-dependent phosphatases 206-504 1.5e-87 286.6 In-house 11-304 (309) alignment 
Range on Protein: 206-504
Range on HMM: 11-304/309.0
KITIEFVNEMIEWMKGQKSVHKKYVCKILKQSFEMMKELPTLVDIDhdttMNITICGDTHGQFYDLLNIFKINGSPSEeKPYLFNGDFVDRGSFSFEIII
..........||... .| ...... ..| . .|..|. |.|....    |.|...|| |||..|||......| |.|   ..|.||.||||..| |.. 
elilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpdslevll

TLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFGKDgVTLDDIRKIKRNAPDPKDnELVQC
.|||.|||||....| |||||.  .|..||| .|...||.. ... | ......|||.|.......|||||.    ..||.||...|    | | .|.  
lllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdl.llldqirelerpleipld.gllcd

LLWSDPQ-SNPGIAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITED-KIKITTFEAVEHPN
||||||.   .|.||. ||.||.||.....|||| |.|..|||.|.. . ||..  ||.|||||||||||.. ||||... |.|| .| ...||.|... 
llwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll

I
.
l
0053225 Metallo-dependent phosphatases 206-490 3.5e-80 262.5 In-house 3-281 (293) alignment 
Range on Protein: 206-490
Range on HMM: 3-281/293.0
KITIEFVNEMIEWMKGQKSVHKKYVCKILKQSFEMMKELPTLVDIDhdttMNITICGDTHGQFYDLLNIFKINGSPSEeKPYLFNGDFVDRGSFSFEIII
.... ... .||... .| ...... ..| . .|..|. |.|....    |.|...|| ||...|||..... | |.|   ..|.||.||||..| |.. 
slilllldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevle

TLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKY-SEMVFDLFSELFNWFPLAFVLDESFMVVHGGLfGKDGVTLDDIRKIKRNAPDPKDNELVQ
 |||.|||||....| |||||.  .| .||| .|...|| .. ..| . ......|||.........|||||   | ..||.||.|.|    | .. | .
lllalkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGl.spdlslldqireinrplriplegllld

cLLWSDPQSNPGIAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEDK
 ||||||.   |..|| ||.||.||.....|||| |.| .|||.|.|   ||..  ||.|.||||||||... ||||... . |. 
.llwsdpdlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldegl
subfamily_PPP2C_pd Subfamily PPP2C 213-492 2.1e-68 223.6 In-house 5-279 (290) alignment 
Range on Protein: 213-492
Range on HMM: 5-279/290.0
NEMIEWMKGQKSVHKKYVCKILKQSFEMMKElptlVDIDHDTTMNITICGDTHGQFYDLLNIFKINGSpSEEKPYLFNGDFVDRGSFSFEIIITLLAYKL
...|| .|  |..... | .. ..  |....     .  ..  . .|.||| ||||.|||..||| |. | .  ||| ||.|||| .| | .  | | |.
dklieklkeckqleesevkelcekakeilsk....esnvqevkcpvtvcgdvhgqfhdllelfkiggk.spdtnylflgdyvdrgyysvetvtllvalkv

LYPNHMHLTRGNHETTDMNRFYGFQGEVVAKYSE-MVFDLFSELFNWFPLAFVLDESFMVVHGGLFGKdGVTLDDIRKIKRNAPDPKDNELVQcLLWSDP
 |.. . . |||||. .. . ||| .|.. ||..  |. .|..||...||. ..||  ...||||  .   |||.||...|    |..  |.. ||||||
rykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglsps.idtldkiraldrlqevphegplcd.llwsdp

QSNPGIAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEDK-IK
.   | . | || |  || |....| |.|.|. |.|.|..  .||.   |  ..|.||||||| . || .. ... ..   .
ddrggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkys
subfamily_PPP4C_pd Subfamily PPP4C 214-499 1.8e-71 233.7 In-house 5-285 (288) alignment 
Range on Protein: 214-499
Range on HMM: 5-285/288.0
EMIEWMKGQKSVHKKYVCKILKQSFEMMKELPTLVDIDHdttmNITICGDTHGQFYDLLNIFKINGSPsEEKPYLFNGDFVDRGSFSFEIIITLLAYKLL
..|| ..  . .... | .. ... |.. |   .  .|      .|.||| ||||||||..||..|.  .|. ||| ||||||| .| | .. |||.|. 
rqieklrrcelikeeevkalcakareilveesnvqrvds....pvtvcgdihgqfydllelfkvggdv.petnylflgdfvdrgfysvetfllllalkvr

YPNHMHLTRGNHETTDMNRFYGFQGEVVAKYS-EMVFDLFSELFNWFPLAFVLDESFMVVHGGLFgKDGVTLDDIRKIKRNAPDPKDNELVQcLLWSDPQ
||....| |||||. .. . |||  |.. ||    |. . .|.|....|| ..|.. ..|||||   .  |||.|| | |.   |..  |.. ||||||.
ypdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhggls.psistldeirsidrkqevphegplcd.llwsdpe

SNPGIAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEDK-IKITTFEAV
   | | | || |  || ||. .| ..|... |.|.|..  .||.   . ...||.|||||| . ||. . ... |.   . . |||.
daegwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
subfamily_PPP6C_pd Subfamily PPP6C 214-500 2.1e-66 217.0 In-house 4-285 (290) alignment 
Range on Protein: 214-500
Range on HMM: 4-285/290.0
EMIEWMKGQKSVHKKYVCKILKQSFEMMKELPTLVDIdhdtTMNITICGDTHGQFYDLLNIFKINGSPSEEkPYLFNGDFVDRGSFSFEIIITLLAYKLL
. ||..|  | . .. . |. ..  ... |  ... .    .  .|.||| |||||||...|.  |.  ..  |.| ||||||| .|.| .  ||. |. 
kwielakkckylpendlkklcdlvldllleesnvqpv....sspvtvcgdihgqfydleelfrtggqvpdt.syvflgdfvdrgyysletftrlltlkak

YPNHMHLTRGNHETTDMNRFYGFQGEVVAKYSE-MVFDLFSELFNWFPLAFVLDESFMVVHGGLFgKDGVTLDDIRKIKRNAPDPKDNELVQcLLWSDPQ
||... | |||||.  . . |||  | . || .  ..  ....|. ...| ..||. . |||||   |  |||.|| |.|.   |..  ... |.||||.
ypdritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGgls.pdvktldqirvieraqeiphkgafcd.lvwsdpe

SNPGIAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEDK-IKITTFEAVE
     | |.|| |  ||  ||. |.. |||. |.|.|.. |.|..   | .|.||.|||||| . ||. | ... ...  .   |.||.
dvetwavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavp
subfamily_PPP3C_pd Subfamily PPP3C 215-504 1.6e-76 250.9 In-house 31-327 (452) alignment 
Range on Protein: 215-504
Range on HMM: 31-327/452.0
MIEWMKGQKSVHKKYVCKILKQSFEMMKELPTLVDIDhdttMNITICGDTHGQFYDLLNIFKINGSPSEEKpYLFNGDFVDRGSFSFEIIITLLAYKLLY
. | .. .  .... . ||.... ...|. .||....      ||..|| ||||||||..|...|.|.. | ||| ||.||||.||.|... |.| |. |
lkehflkegrleeeaalkiieeaakllkkektlleve....aPitviGdihGqfydllklfevgGdPastk.ylflGdyvdrGyfsiecvlylyalkiay

PNHMHLTRGNHETTDMNRFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLfGKDGVTLDDIRKIKRNAPDPKDNELvQCLLWSDPQSN
|....| |||||.  .  .. |. |.  |||| |.| . | |. .||| .|.. |. ||||| . .  .||||.|..|    |.   |   ||||||  .
pstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGl.speikslddikkldrfkeppasGpl.cdllWsdPled

PGIAP--------SSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDD------GSLITVFSAPNYCDQSGNLGSFINITEDKIKITTFEAVE
 | .         | ||  ....   . .||..|.| .|||.||....||.   .       ||||.||||||.|   | .. ... .....|  |....
ygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvmnirqfnssp

HPNI
||  
hpyw
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 222-497 5e-46 150.2 In-house 3-298 (302) alignment 
Range on Protein: 222-497
Range on HMM: 3-298/302.0
QKSVHKKYVCKILKQSFEMMKELPTLVDIdhdtTMNITICGDTHGQFYDLLNIFKINGSPSEEK----------PYLFNGDFVDRGSFSFEIIITLLAYK
.|. .|. . .....  |..|.  ||..|    .  .|| || |||| ||. |.. . |  |.|           ..| ||.||||| | | |  ..|.|
kkeysksellllieaviellkkektlaei....spPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalk

LLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKYSEM----VFDLFSELFNWFPLAFVLDESFMVVHGGLFGKdGVTLDDIRKIKRNAPDPKDNELVQCLL
.|||..  | ||||||  .|  |||..|.. ....     ... | | | ..||| .. |  . ||||.  |   .|.||.||||  ..  .. | | ||
vlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk.lesledikkikrplkevtedslaqdll

WSDPQSNPGIAP----------SSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINIT-EDKIKITTF
..||    ..|             ||. | |     | . |  ||. |.|.| .  .|..   |  |.|.||||.| ..| | |. ...  . |..|...
fadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvl

E
 
r
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 222-496 7e-46 149.8 In-house 4-298 (302) alignment 
Range on Protein: 222-496
Range on HMM: 4-298/302.0
QKSVHKKYVCKILKQSFEMMKELPTLVDIdhdtTMNITICGDTHGQFYDLLNIFKINGSPSEEK----------PYLFNGDFVDRGSFSFEIIITLLAYK
.|. .|. . .....  |..|.  ||..|    .  .|| || |||| ||. |.. . |  |.|           ..| ||.||||| | | |  ..|.|
kkeysksellllieaviellkkektlaei....spPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalk

LLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKYSEM----VFDLFSELFNWFPLAFVLDESFMVVHGGLFGKdGVTLDDIRKIKRNAPDPKDNELVQCLL
.|||..  | ||||||  .|  |||..|.. ....     ... | | | ..||| .. |  . ||||.  |   .|.||.||||  ..  .. | | ||
vlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk.lesledikkikrplkevtedslaqdll

WSDPQSNPGIAP----------SSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINIT-EDKIKITTF
..||    ..|             ||. | |     | . |  ||. |.|.| .  .|..   |  |.|.||||.| ..| | |. ...  . |..|...
fadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvl
subfamily_PPP1C_pd Subfamily PPP1C 223-491 6.1e-79 258.1 In-house 8-270 (282) alignment 
Range on Protein: 223-491
Range on HMM: 8-270/282.0
KSVHKKYVCKILKQSFEMMKELPTLVDIDHdttmNITICGDTHGQFYDLLNIFKINGSPSEEkPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTR
 ..... . ..||.. |.... |.|.....     ..|.|| |||..|||..|...|.|.|.  ||| ||.||||..| |.|. |||||. ||....| |
vklkeaeieallkkareillsqpillelea....PvkivgdihGqyadllrlfetsgaPpes.nylflGdyvdrGkqsletivlllaykikypenlfllr

GNHETTDMNRFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLfGKDGVTLDDIRKIKRNAPDPKDnELVQCLLWSDPQS-NPGIAPSS
||||....||.|||  |.  .||  ..  | . ||..||| ..||  ..|||||  ..   |..||||.|    |..  |.  ||||||.. . |.. ..
GnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGl.spelksleqirkiqrPlevpek.gllcdllWsdpdkevlgwsend

RGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEDKI
||| . ||.|| ..||..|.|. |.|.|.| |.||.   .  |.|||||||||.. .| |. ....|...
rGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeell
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 223-495 3.2e-58 190.0 In-house 14-285 (290) alignment 
Range on Protein: 223-495
Range on HMM: 14-285/290.0
KSVHKKYVCKILKQSFEMMKELPTLVDIDHdttmNITICGDTHGQFYDLLNIFKINGSPSEEKpYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTR
..   | . .||..  |... ||.|... .     |.| || |||. .||. |.  | | . | .|| ||.||||. |.|. . |. ||..|....|| |
dafsdkdileilekieeileplpallevea....pivivgdihgqldallryfdavgyppkvk.flflgdyvdrgakslevslllfcykiryskkvhllr

GNHETTDMNRFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFGKdGVTLDDIRKIKR-NAPDPKDNELVQCLLWSDPQS---NPGIA
||||.  .||.|||. |.. | .  ..  . ..|. ..|   ...  . .|||.  |   . . .. .|. ..|   |. |.  |||.||.    .    
gnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqk.iesweslkalkkprvpltcdeglqvdllwadptrdkddtial

PSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITED-KIKITT
   |.. | || ..   .||.  || |.|.|||||.|...  |  |.|||||| |. .  |||. ....|  ...|..
nkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivv
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 223-492 1e-56 185.4 In-house 21-286 (297) alignment 
Range on Protein: 223-492
Range on HMM: 21-286/297.0
KSVHKKYVCKILKQSFEMMKELPTLVDIDhdttMNITICGDTHGQFYDLLNIFKINGSPSEeKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTR
| . .. | |.|  .....|   ..|...      | .||| |||| ||| .|.  | |     ||| ||.|||| || | |. |||||. .|  . | |
kviteervlklldlaldvfkaqksmvevn....apikvcgdihgqfpdllrlfhrggwppt.anylflgdyvdrgrfsietivlllaykvkfpgnlfllr

GNHETTDMNRFYGFQGEVVAKYSE-MVFDLFSELFNWFPLAFVLDESFMVVHGGLFG--KDGVTLDDIRKIKRNApDPKdNELVQCLLWSDPQSN-PGIA
||||   .|. |||  |.  .|    ..  | ..|||.||. .. .  ...||||     . .||| .|||.|.  . | ..||  |||.|| |   |. 
gnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierst.egk.erlvadllwadpisglsgfm

PSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEdKIK
   || |. || |   .   | .|  . |.|.| . ||..     |.|.|||| || |  |  .|.   | |..
enqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscde.klq
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 225-493 1.3e-64 210.9 In-house 10-276 (287) alignment 
Range on Protein: 225-493
Range on HMM: 10-276/287.0
VHKKYVCKILKQSFEMMKELPTLVDIDHdttmNITICGDTHGQFYDLLNIFKINGSPSEEKpYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGN
.  | . ..|..  |... ||.|.....     |||.||.|||. |||.||.  | ... . ||| ||.||||. |.|... |...|..||...|| |||
fsdkdilevlekieeileplpallevea....pitivGdihGqlddllrifnavGaapkvq.ylflGdyvdrGakslevslllfslkiaypkkvhllrGn

HETTDMNRFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFgKDGVTLDDIRKIKR-NAPDPKDNELVQCLLWSDPQSN-PGIAPS-S
||   .|. |||. |.  |..| ..  | ..|. .||   ...  . .|||.  ..  .||... .|. . |   |. |.  |||.||. .  ....   
hevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGis.pklksldslkalkkpttplacdeglqvdllwadpekdaktfelnki

RGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITED-KIKI
|.. | ||  .   .||. ... |.|.|||.|.||.   |  |.|||||| |. .  |||. . ...  ....
raisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsf
PP2Ac_SM00156 226-491 1.5e-95 312.4 In-house 2-262 (271) alignment 
Range on Protein: 226-491
Range on HMM: 2-262/271.0
HKKYVCKILKQSFEMMKELPTLVDIDhdttMNITICGDTHGQFYDLLNIFKINGsPSEEKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNH
.|..| ..|... |..|. ..||...     ..|..||.|||..|||.... .| ...|..|.|.||.||||..| |.|..|.|.|.|||....| ||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

ETTDMNRFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFGkDGVTLDDIRKIKRnAPDPKDNELVQCLLWSDP-QSNPGIAPSSRGV
|. ..|..|||. || .||.. ... |.|.|...||| ..|......||||   .  .||||||.|| . .. ...|.  |||||| |...|..||.||.
EsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp.eleslddirklkr.vkekpeegllidllwsdpeqkekgfqpskrgl

GVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEDK-I
.|.||.|....|||.|||. |||.|||...||..  |..|.|.||||||||...|....... ..  .
svvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlkl
PPP_3 227-491 1.4e-94 309.1 In-house 4-263 (271) alignment 
Range on Protein: 227-491
Range on HMM: 4-263/271.0
KKYVCKILKQSFEMMKELPTLVDIDhdttMNITICGDTHGQFYDLlNIFKINGSPSEEKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHE
.. . ...|.  |.... ..||.|.     ..|.|||.|||..|| .... || ||.|. |||.||.||||..|.|....|||.|..||...||.|||||
enelkelvkklkeilekesnlveis....apvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhE

TTDMNRFYGFQGEVV-AKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFGKDGvTLDDIRKIKRNAPDPKDNELVQCLLWSDPQSNPGIAPSSRGVG
....|. |||. ||.  |... |.. ..|.|...||| ..||...||||||. .   .||.|.|..|.   |.. .|.. ||.|||... |...|.||.|
srqinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsik.sldqikklerkievpeegklldlllssdpekeeglenskrGag

VYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEDKI
..||||||..||..|.|..|||.||.||.||.|  ||...|||||||||.. .|.|......|.. 
llFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealt
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 228-491 5.4e-55 179.7 In-house 30-285 (299) alignment 
Range on Protein: 228-491
Range on HMM: 30-285/299.0
KYVCKILKQSFemmKELPTLVDIDHdttmNITICGDTHGQFYDLLNIFKINGSPSEeKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHET
. .|.. |..|    . ..|....      | .||| |||. ||| ||...| | .   .|| ||.||||   .|.|. ||..|. ||..... ||||| 
qtlcavaksvf...asqasllevea....piivcgdihgqysdllrifdkagfppd.vnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

TDMNRFYGFQGEVVAKY-SEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFGKdGVTLDDIRKIKRNApDPKDNELVQCLLWSDPQ-SNPGIAPSSRGVG
  .|| |||  |.  .| |  .. .| . |...||. ..    ...||||  |   ||| .|.. |   || .  |   |||.||. |  .  .  ||| 
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspk.lqtldqlrdltrpq.dppnpslgidllwadpdqsvkdwlanvrgvs

VYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEDKI
  ||.|| .  ..  ..  . |.|.| . ||..  .  |.|.|||| || |  |  . ... |. .
yvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlv
subfamily_PPZ_pd Subfamily PPZ 228-490 4.6e-51 167.1 In-house 28-284 (300) alignment 
Range on Protein: 228-490
Range on HMM: 28-284/300.0
KYVCKILKQSFEMMKELPTLVDIdhdtTMNITICGDTHGQFYDLLNIFKINGSPSEeKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHET
. . .| ... |..   |.|...    . .. | || |||. ||| .|   | |     ||| ||.||||  |.| |. ||.||. ||. . | ||||| 
seilqicikarelflaqpallel....spsvkivgdvhgqyadllrlftkcgfpps.anylflgdyvdrgkqsletillllcykikypenffllrgnhec

TDMNRFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFGKdGVTLDDIRKIKRNApDPKDNELVQCLLWSDPQSNP-GIAPSSRGVGV
... | |||  |.  .    ..  | . || .||| ..    ..|||||      ..|.||.. | . |  |  |.. ||||||  ..       |||  
anvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspv.lnsmdeirhvvrpt.dvpdfglindllwsdptdssnewednergvsy

YFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEDK
 .      .||..  .  . |.| | | ||.. .| ||.||||||||| .  | |. ....|  
cynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegl
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 229-486 8.8e-56 182.4 In-house 7-260 (284) alignment 
Range on Protein: 229-486
Range on HMM: 7-260/284.0
YVCKILKQSFEMMKELPTLVDIDHdttmNITICGDTHGQFYDLLNIFKINGSPSEeKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETT
 |  .| ..|..... | |....      | |||| |||| ||| .|  || |     ||| ||.||||   .| |. |.|||...|||. . ||||| .
dvetllfhafsifnkqpmlievns....pinicgdihgqfsdllrlfdkngfphr.anylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecs

DMNRFYGFQGEVVAKYSE-MVFDLFSELFNWFPLAFVLDESFMVVHGGLfGKDGVTLDDIRKIKRNAPDPKDNELVQCLLWSDPQS-NPGIAPSSRGVGV
 .|. |||  |.  .| .  |.  |  .|  .||. .. .  ...|||.  |    . ..| |||   .|. | |   .|||||   . |  | ||||  
linkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggv.skmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsy

YFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINI
 || |  |..|   ..  ..|.|.| . ||..  .  |.|.|||| || |  |  . . .
vfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyv
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 230-497 1.3e-63 207.8 In-house 11-270 (280) alignment 
Range on Protein: 230-497
Range on HMM: 11-270/280.0
VCKILKQSFEMMKELPTLVDIDHdttmNITICGDTHGQFYDLLNIFKINGSPSEeKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTD
. .....  ....   |.|..|      ...||| |||. ||| .|.  . | . . ||| ||.||||.. .|.|. |||||. |||.. . |||||. .
idrviekckkiltaqatmvevda....pvavcgdlhgqytdllrlfarvsfppd.qnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

MNRFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFgKDGVTLDDIRKIKRNApDPKDNELVQCLLWSDPQ-SNPGIAPSSRGVGVYF
.|| |||. ||  .||. ... | ||.. .||. ..    ...||||  .. |.|||.....|   |..|. | . |||.||.    | | .|||| | |
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhggls.qklvslddlaelrrpf.dsedeclamdllwadpenkvtgwaensrgvsvif

GPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEdKIKItTFE
| .| . . .  ..  |.| |.| . ||..  |  |.||||||.|...  |  . . . | .... .||
ganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivde.rliv.sfe
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 232-498 6.9e-55 179.2 In-house 15-274 (281) alignment 
Range on Protein: 232-498
Range on HMM: 15-274/281.0
KILKQSFEMMKELPTLVDIDHdttmNITICGDTHGQFYDLLNIFKINGSPSEEKpYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMN
.....   .. |  .||.||.     |.. || |.|| || ..|.. | ..||. ..| ||.||||  |.|..| |...|. |.... | |||||.. .|
nvireveaifseekaLveidk....PivvvGdlhaqfndlkrlfellgrvpeev.lvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

RFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFgKDGVTLDDIRKIKRNApDPKDNELVQCLLWSDPQS-NPGIAPSSRGVGVYFGP
. |||  | | || | .. || . || .|..   ..  ...||||   . ..||..|.. .   .. |  ||  |||.||..   .   ||||..  || 
kiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGls.Peltaldelrnrpkpi.rnldrGlviDllwadpdnkveewkassrGssftfGk

DVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEdKIKITTFEA
.|     |. ..  |||.| |   ||..     ||||||.||||..  | .. . . | ...|.. . 
nvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvde.tlgislval
PPP_1 233-485 1.5e-88 289.5 In-house 5-263 (264) alignment 
Range on Protein: 233-485
Range on HMM: 5-263/264.0
ILKQSFEMMKELPTLVDIDHDTTMNITICGDTHGQFYDLLNIFKiNGSPSEEKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNR
 |..  ...|||..  ..  ... .||.|||.||||.|||..|| .| ||.|. |||.||.||||..|.||...|||.|| ||....| |||||.. ...
elaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfk.vggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtk

FYGFQGEVV-AKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFGKDGvTLDDIRKIKRNAPDPKDNELVQCL-------LWSDPQSNPGIAPSSRGV
 |||. ||.  |||. ........|...||| ..||....|||||  .   .||.|||..|.   |.. .| . |       |..|.... ..| | ||.
vygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeld.lldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFIN
| .||.|||..||..|||..|||.|||||.||..  .....|.|||.||... .|.|....
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_PPG1_pd Subfamily PPG1 240-497 2.1e-63 207.4 In-house 25-294 (300) alignment 
Range on Protein: 240-497
Range on HMM: 25-294/300.0
MMKELPTLVDIDHDTTMNITICGDTHGQFYDLLNIFKINGsPSEEKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGE
 .|||        .    .|. || ||||||.|.|||| | .  .  ||| ||.|||| .| | |. |.. || ||  ..| |||||. .. . ||| .|
klkellvkesnvieirspvtvvgdvhgqfydvleifkigg.qvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyte

VVAKY--SEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFgKDGVTLDDIRKIKRNAPDPKDNELVQcLLWSDPQ----------SNPG--IAPSSRGVG
.. ||     |.. ..|.|... || ..||. ..|||||   .  ..|.|. . |    |..  | . ||||||.           . |  .  | || |
clrkyggnsrvwkylteifdylvlaaiideeiycvhggls.psvlsidqikvldrfrevpnegalad.llwsdpeennnptldhpdregqhfvvsqrgag

VYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITED-KIKITTFE
  .| ||. .||. |..  |||.|..  .||||  |. | ||.|||||| . ||  | ... |  .  . ..|
ysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvye
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 245-489 1.4e-44 145.5 In-house 40-281 (307) alignment 
Range on Protein: 245-489
Range on HMM: 40-281/307.0
PTLVDIDHDttmnITICGDTHGQFYDLLNIFKINGSPSEeKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVA--
 .|||||        . || |||| ||.|.| . | | |   |.| ||.|||| .|.|.|. |..||. ||... | ||||| . .|. |||  |.|.  
kalvdidpp....cvvvgdlhgqfndlinmfillgrppe.tvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsi

-KYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFGkDGVTLDDIRKIKRNAPDPKdNELVQCLLWSDPQS-NPGIAPSSRGVGVYFGPDVTRRFLKEN
 |  | .. ||   || .|.. ..    ...||||       ||..|.  .   .|    .|. .||.||.        |||| |. || .|     |  
pkcgeeiwalfqrcfnnlpisaliatkilcmhgglsp.altcldelrnhpkpirnpf.rgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrl

NLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITED
 .  |||.|..   || .     |||.|||| ||.   | |  ... | 
gveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdet
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 250-491 6e-64 209.2 In-house 29-274 (284) alignment 
Range on Protein: 250-491
Range on HMM: 29-274/284.0
IDHDTTMNITICGDTHGQFYDLLNIFKINGSP-----SEEKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKY
.  .  . ..|.|| |||| ||| ....|| |     ..|| ||| ||.|||| || |.|  |.|||||.|... | |||||.  .|. |||  | . .|
lkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckkry

SEMVFDLFSELFNWFPLAFVLDESFMVVHGGLfGKDGVTLDDIRKIKRNApDPKDNELVQCLLWSDPQSN-PGIAPSSRGVGVYFGPDVTRRFLKENNLS
|| ... |   || .||. |...  . .|||.  .| . |... |..|   |  |  ..  | |.||...  | . | || |  ||..  ..|||. .| 
sealyeafqlafnamplcavvskkiicmhggi.sedlldlkqldklerpi.dipdigviadltwadpeaevegykesprgagkvfgakavkeflkkfkld

TIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEDKI
 ..|.|.|   ||..  |  |.|.|||| || |  |... .|. |. .
lvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 250-283 3.2e-07 22.8 In-house 30-64 (317) alignment 
Range on Protein: 250-283
Range on HMM: 30-64/317.0
IDHDTTMNITICGDTHGQFYDLLNIFKINGSPS-E
.  .    .||.|| |||| ||| ....|| |  .
lkleleapvtivGdihGqfedllalldlnGwplss
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 256-487 7.4e-46 149.8 In-house 33-262 (280) alignment 
Range on Protein: 256-487
Range on HMM: 33-262/280.0
MNITICGDTHGQFYDLLNIFKINGSPSEEKpYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKYSEMVFDLFSEL
  | . || | |. |.  .| . |   |||  .| ||.||||    |..| |.. |. | ....| ||||||  .|. |||  |.  ||   ..  |   
apikvigdihaqyqdmnrlfdligrvpeek.lmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygvglwwdfqsc

FNWFPLAFVLDESFMVVHGGLFgKDGVTLDDIRKIKRNApDPKDNELVQCLLWSDPQSN-PGIAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEK
|| .|.. .. .  ...||||   . . || ||.| | . .| |  |.  ||||||  .  |   | ||.   ||  |  .  |  ..  |||.|.| . 
fnrmpmsgliskrvlcmhggls.pelinldtirniprpc.epldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqd

GYQIDDDGSLITVFSAPNYCDQSGNLGSFINIT
||..     |||||| |||| |  |  . . . 
gyemmagrrlitvfsvpnycaqftnaaavvcln
Metallophos Calcineurin-like phosphoesterase 256-452 3e-38 125.1 Pfam-A 1-199 (200) alignment 
Range on Protein: 256-452
Range on HMM: 1-199/200.0
MNITICGDTHGQFYDL---LNIFKINGSPSEEKPYLFNGDFVDRGSFSFEIIITL--LAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVV---------
..|...||.||...||   |.|.. ......  ..||.||.||||  | |..  |  |..|||.|.. .|.|||||   .| .|||  |.          
lrilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang

-------------------------AKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFGKDGVTLDDirkikrnapdpkdnelvqcllwsdpqsnpg
                          ..   ... . | |.. ||.   |  . ..||.|.. .| ..|                               
eeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi..............................

iapssrgVGVYFGPDVTRRFLKENNLSTIIRSHEVK
        ...||||... .|.....  ..|.|. |
.......gselfgpdalekllekygvdlvlrGHtHk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 257-479 2.1e-44 145.2 In-house 8-235 (263) alignment 
Range on Protein: 257-479
Range on HMM: 8-235/263.0
NITICGDTHGQFYDLLNIFKINGSPSEeKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKYS-----EMVFDL
 | ||||||||. ||| ||.  |. ..   ||| ||.|||| .|.|.|. |.. ||  | .||| |||||   .|. |||. |.  ..      | |.. 
pinicgdthgqyndllrifnacgaatk.tqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynh

FSELFNWFPLAFVLDESFMVVHGGLFGKdGVTLDDIRKIKRNAPDPKDNELVQCLLWSDPQSN-PGIAPS-SRGVGVYFGPDVTRRFLKENNLSTIIRSH
| ..|...||. .. .  ...|||.  .   .||||| |       |   |   |||.||. .  |. |   | .   ||      . |  ..  |.|.|
fnqvfsymplcaivskrilcmhggisph.lkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrah

EVKEKGYQIDDDGSLITVFSAPNYCDQSGN
.| | || .  |  |||||||  |  .  |
qvveygyaffadrrlitvfsasryqielcn
PPP_4 258-452 1.3e-71 233.7 In-house 1-197 (197) alignment 
Range on Protein: 258-452
Range on HMM: 1-197/197.0
ITICGDTHGQFYDL-LNIFKINGSPSEEKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKYSEMVFDLFSELF
.|..||.|||..|| |...|. | ||||. |.|.||.||||..|.|....|||.|| ||....| |||||. ..|..|||. ||. |... ... . ..|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NWFPLAFVLDESFMVVHGGLFGKDGvTLDDIRKIKRNAPDP-KDNELVQCLLWSDPQ-SNPGIAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVK
.. ||| ..||...||||||. .   .||.|..|.|. . | ..... . ||||||. .. |.|.| ||.|..||||||..||..|||. ||||||.|
dllplaalidekvlvvhgglsdele.sldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshelk
PPP_2 258-452 5e-70 228.2 In-house 1-198 (198) alignment 
Range on Protein: 258-452
Range on HMM: 1-198/198.0
ITICGDTHGQFYDLlNIFKINGSPSEEKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVV-AKYSEMVFDLFSELF
.|.|||.|||..|| .|.. || ||.|. |||.||.||||..|.|....|||.|| ||...||.|||||....|. |||. ||.  |... |.. ..|.|
vtvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevf

NWFPLAFVLDESFMVVHGGLFGKDGvTLDDIRKIKRNAPDPKDNELVQCL----LWSDPQSNPGIAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVK
...||| ..||...||||||. .   .||.|.|..|.   |....|.. |    |....... ..|.|.||.|..||||||...|..|.|..|||.||||
elLplaalidekvlvvHGGlseeik.lldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHevk
PPP_5_Dcr2 258-452 7.5e-68 221.4 In-house 1-199 (199) alignment 
Range on Protein: 258-452
Range on HMM: 1-199/199.0
ITICGDTHGQFYDLLNIFKING-SPSEEKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAK-YSEMVFDLFSEL
.|.|||.|||..||| |.  .|  ||||. |.|.||.||||..|.|....|||.||.||...|| |||||. ..|..|||. ||. | ... ... .|..
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNWFPLAFVLDESFMVVHGGLFGKDGvTLDDIRKIKRNAPDP-KDNELVQCLLWSDPQ-SNPG-IAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVK
|.| ||| ..||...||||||. .   ......||.|. . | ...|  . ||||||. .  |  ..| ||.|..||||||..||..|||. ||||||.|
fdwlPlaalidekvlvvhgglspeik.siellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_PPPLV_pd Subfamily PPPLV 259-495 2.4e-45 148.0 In-house 27-284 (290) alignment 
Range on Protein: 259-495
Range on HMM: 27-284/290.0
TICGDTHGQFYDLLNI---FKINGSPSEEKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKYSE---MVFDLF
 . || ||.. ||  .   .   |       .|| ||.|||| ||.|.|  ||| |.||| ...| |||||   .   . ..||   |. .    |.. |
yvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevweaf

SELFNWFPLAFVLDESFMVVHGGLFG--KDGVTLDDIRKIKRNAPDPKDN-ELVQCLLWSDPQS------------NPGIAP-SSRGVGVYFGPDVTRRF
 . |...||| |.|.  . ||.|.    . .  .  |..|  . .|. |   |   .|||||..            | | .. ..|| |  |. |   .|
nnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleaf

LKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSgNLGSFINITEDKIKITT
||.|||| ..|.|||||||...  .| |.||||. .|| .| |  . | . ..|..| |
lkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvdkkklriit
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 284-495 7.8e-59 192.4 In-house 100-311 (317) alignment 
Range on Protein: 284-495
Range on HMM: 100-311/317.0
EKPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLfGKDGVT
 | ||| ||.|||| ||.|..| |.|.|||||....| |||||.  .|. |||  ||  .||. ... |   || .||. |...  . .|||.  .. . 
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGi.seelld

LDDIRKIKRNApDPKDNELVQCLLWSDPQSN-PGIAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGS
|. . |.||   |  |  ..  | |.||...  | ..|.|| |  ||..  ..|||. .|  ..|.|.| | ||.  .|  |.|.||||.|| |  |...
lkqldklkrpl.dipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaa

FINITED-KIKITT
 ... .. || |..
vlsvdkklkisinv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 285-494 4.8e-50 163.5 In-house 120-327 (339) alignment 
Range on Protein: 285-494
Range on HMM: 120-327/339.0
KPYLFNGDFVDRGSFSFEIIITLLAYKLLYPNHMHLTRGNHETTDMNRFYGFQGEVVAKYSEMVFDLFSELFNWFPLAFVLDESFMVVHGGLFgKDGVTL
| ||| ||.|||| ||.|..| | | || ||....| |||||.  .|  |||  ||  .|   ... | ..|| ||.. |.... |..|||.  .   ..
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggis.ehltsf

DDIRKIKRNAPDPkDNELVQCLLWSDPQS-NPGIAPSSRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSF
...  .||    | |  ..  | |.||.  . |  ||.||  . |||   | |||. .|  .|| |.| | ||.. |   |.|.||||||| |  |  . 
nqfsvfkrpleip.dvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaav

INITeDKIKIT
. |   |.||.
fsid.kklkis
subfamily_PPP7C_pd Subfamily PPP7C 404-490 1e-26 86.6 In-house 238-325 (383) alignment 
Range on Protein: 404-490
Range on HMM: 238-325/383.0
QCLLWSDPQSNPGIAPS-SRGVGVYFGPDVTRRFLKENNLSTIIRSHEVKEKGYQIDDDGSLITVFSAPNYCDQSGNLGSFINITEDK
  .|||||... |  |   || |.|||||||...|.  ||. .||||| | .||..  |  ..|.||| || ..  | |.......|.
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdl