Gene ppp6c in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP6C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP081_AA protein Get Run
DdisP081_AA_6-297 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP6C_pd Subfamily PPP6C 7-294 5.5e-178 583.2 In-house 2-289 (290) alignment 
Range on Protein: 7-294
Range on HMM: 2-289/290.0
LDEWVETARQCKYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPD
||.|.|.|..|||||||||||||..|..|||||||||||.||||.|||||||||||.|||.|||.||||.|||.|||||||||||||||.||.|||.|||
ldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypd

KITLLRGNHESRQITQVYGFYDECQQKYGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPEDIEQW
.|||||||||||||||||||||||..||||.|||||||.|||.||.|||||..||||||||||.|.||||||.|.|. ||||.|.||||.||||||.|.|
ritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvetw

QPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQAVQEERN
. ||||||.||||||| || ||| |.|||||||||.||..||||..|||||||||||||||||||||.|... .|..|.|.||..|..
avsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdeer
subfamily_PPP4C_pd Subfamily PPP4C 7-291 1.6e-154 506.3 In-house 3-287 (288) alignment 
Range on Protein: 7-291
Range on HMM: 3-287/288.0
LDEWVETARQCKYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPD
||. .|. |.|. . |...|.||....|.|.|||||| | ||||.|||||||||||||||| ||.||.|||.|.|||||||.||.|||  |||||.||||
ldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypd

KITLLRGNHESRQITQVYGFYDECQQKYGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPEDIEQW
.|||.||||||||||||||||||| .|||..| |.||| |||.|.||||||||..||||||||...|||.||.| |. |.|||||.|||.||||||.| |
ritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaegw

QPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQAVQE
  ||||||.||||.|...| . |...|||||||||.|||...|.....||||||||||||||||.|| |.|.||.|||||.|...
avsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaa
subfamily_PPP2C_pd Subfamily PPP2C 7-289 2.2e-142 466.4 In-house 4-286 (290) alignment 
Range on Protein: 7-289
Range on HMM: 4-286/290.0
LDEWVETARQCKYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPD
||...|  ..|| | |...|.|||..||.| .|||||.|..|||.|||.||||.||||||| ||..|||||.|.||.|||||||.|| |.| ||| ||..
ldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvryke

KITLLRGNHESRQITQVYGFYDECQQKYGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPEDIEQW
.||.|||||||||||||||||||| .|||| | ||| | .||.|.|.|..|....|.||||||.. |||.|| . |  |.|||||.|||.||||.| . |
ritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrggw

QPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQAV
. ||||||. || ... .|.. |||.|| |||||| |||....|. .||..||||||||||| |.|| |...|.. |  |.. 
gisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
subfamily_PPG1_pd Subfamily PPG1 7-291 2.5e-126 414.0 In-house 1-298 (300) alignment 
Range on Protein: 7-291
Range on HMM: 1-298/300.0
LDEWVETARQCKYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPD
||| .|  .... |||  .|.|....||||..||||. .|||||. ||.||||||.||.|| ||.||||||.|.||.||||.||.|| . |..|| ||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

KITLLRGNHESRQITQVYGFYDECQQKY-GNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPE----
.|||||||||||||||||||| || .|| || . ||| | .||.|.|||||| .. ||||||||.|...|||... |  |.|.|| ..||.|||||    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DIEQ--WQPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQAVQE
      | |   .. |.||||. .| .|. .| . | .| | |||||..|||. .||| | |||||||||||||| |||| |.|...| |.....  |
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
0045823 Metallo-dependent phosphatases 7-297 1.1e-119 393.0 In-house 30-332 (473) alignment 
Range on Protein: 7-297
Range on HMM: 30-332/473.0
LDEWVETARQCKYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPD
||...|. . ...|||.||.||....||.| .|.|....  .....||||||..|||.|..  |  |....||.||.||||..|||.. .||||| .||.
ldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypg

KITLLRGNHESRQITQVYGFYDECQQKYgNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPEDIEQ-
...|||||||.|.....|||.||. .|| ... ....  ... | |||.|.||.|.||||||| ...||||| | | ||||..|...||.||||..... 
nvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddgd

-------WQPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNS------LVTVWSAPNYCYRCGNVASILSLNENLdRDFKIFQAVQEE
       ...||||||.||| ... || . |||.||.|.|. |.|||...||..      ..||.||||||.|.|| |..| ..|.| . |..|.... .
gllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphp

RNIPT
  .| 
lilpl
0049330 Metallo-dependent phosphatases 7-291 6e-112 366.6 In-house 17-301 (309) alignment 
Range on Protein: 7-291
Range on HMM: 17-301/309.0
LDEWVETARQCKYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPD
||...|. ...|.|.|..|..|....||.|..|.|....  .....||||||..|||.|..  | .|....||.||.||||..|||....||||| .|||
ldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypd

KITLLRGNHESRQITQVYGFYDECQQKYGnVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPE-DIEQ
...|||||||.|.....|||.||...||| .. |.... ... | |||.|.||.||||||||| . .||||| . | ||||..|..|||.||||  ..| 
nvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpireg

WQPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQAVQE
..|.|||.|..||  .. .| ..|||.||.|.|..|..||...||..|.||.||||||.|.||....| ..|.| . |..|..|. 
fapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
0053225 Metallo-dependent phosphatases 7-289 3e-108 354.5 In-house 9-291 (293) alignment 
Range on Protein: 7-289
Range on HMM: 9-291/293.0
LDEWVETARQCKYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPD
|| ..|. ...|.|.|..|..|.. .||.|..|.|..... .....|||||...|||.|..  | .|....||.||.||||..|||....|||||..|||
ldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypd

KITLLRGNHESRQITQVYGFYDECQQKYGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPEDIEQW
...|||||||.......|||.||. .|||. . |.... ... | |||.|.||.|.||||||| . .||||| | | |.||.||...||.|||| ... |
nvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsgw

QPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQAV
 ||.||.|..||  .. .| ..|||.||.|.||.|..||...||..||||.|||||..|.||....| |.|.| ..||.| .|
lpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_PPP5C_pd Subfamily PPP5C 9-292 7.5e-81 264.6 In-house 23-312 (322) alignment 
Range on Protein: 9-292
Range on HMM: 23-312/322.0
EWVETARQCKYLPENDLKKLCERVKELLLEESNVQPVR----SPVTICGDIHGQFYDLLELFKTGGEVPD-TNYVFMGDFVDRGYYSLETFTYLLALKAR
| .|. .. |.|..    |.  ..|||| ... .  ..    . .|.||||||||||||..|.  | . .   |.| ||||||| .|.|.   ||..|  
ellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkll

YPDKITLLRGNHESRQITQVYGFYDECQQKYGNvNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSP-KVRTLDQIRIISRNLEIPHEGPFCDLMWSDPED
||... | |||||| .. ..||| .|...|| . .  .  | ||..| || .|. ||| |||||   .  |||..| |.|| . |.|| ...|.||||..
yPnhfflsrGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe

IEQWQPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSL-NENLDRDFKIFQAVQEE
 .  .|| || |  ||  || .| . |.|.|| |.|.. .|||. . | .|.||.|||||| . || .....| ...|.  || |.||.  
anGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeavehp
subfamily_PPP7C_pd Subfamily PPP7C 11-183 1.4e-34 112.5 In-house 24-202 (383) alignment 
Range on Protein: 11-183
Range on HMM: 24-202/383.0
VETARQCKYLPENDLKKLCERVKELLLEESNVQPVR----SPVTICGDIHGQFYDLLE-LFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYP
.|. .. | |  . . ..    |. | .  |.. |       ||.|||.||.. |||  |.| |   .. .||| |||||||  |.|    ||||   ||
ieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvyp

DKITLLRGNHESRQITQVYGFYDECQQKYG--NVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVrTLDQIRIISRN
 .. | |||||   .   |||  | ..||   . .  .    || .| ||..|| |.| ||||.| |   |. .  |.|.
kevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdkt.dlelldkiers
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 13-289 5.8e-92 300.9 In-house 17-294 (298) alignment 
Range on Protein: 13-289
Range on HMM: 17-294/298.0
TARQCKYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLR
... .| . |.|..||.| .|... . . .  | .|...|||||||. ||| ||. .|  ||.||.|.||.|||| ..||. . ||| |..||... |||
ekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllr

GNHESRQITQVYGFYDECQQKYGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPED-IEQWQPSPR
||||  .| .|||||.||...| ... ..    ||. | |.|.| |..||.|||||.|...|||.| ..|  . ..|    ||.|.|||. ...|... |
GnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensr

GAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQAV
|..  ||..| ... .   ..|..||||.||.|| .. .. |||..|||.|| .  | |......|.|   |....  
GvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 16-289 9e-81 264.4 In-house 20-294 (299) alignment 
Range on Protein: 16-289
Range on HMM: 20-294/299.0
QCKYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNH
  | . |..|..||.  |. ..... .  | .|. .|||||||. ||| .|.  |  ||.|..|.||.||||   ||. | ||. | .||... .|||||
ltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnh

ESRQITQVYGFYDECQQKYGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPED-IEQWQPSPRGAG
|   | .|||||.||...|     |      |... |. .| ...||.|||||||..||||.| ..|  . |      ||.|.||.. . .|..  ||  
ecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvs

WLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQAV
..|| .| |.  .  ...|..||||.||.|| .. .. |||..||| || .  | |.|. ..|||   |....  
yvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 17-287 2.3e-72 236.8 In-house 20-293 (297) alignment 
Range on Protein: 17-287
Range on HMM: 20-293/297.0
CKYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHE
.| . |. . || .   ...  . ..  | .|. .|||||||| ||| ||. ||  | .||.|.||.|||| .|.||   ||| | ..| .. |||||||
skviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhe

SRQITQVYGFYDECQQKYGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSP---KVRTLDQIRIISRNLEiPHEGPFCDLMWSDPE-DIEQWQPSPRG
   . .|||||.|||..|  |  .     ||..| |. .|  |.||.||||||   |  ||| .| | |. |  .|.  .||.|.||   .  .    ||
cefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisglsgfmenqrg

AGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQ
||  ||     .      |.|.|||||.||.|| ..    |||..||| || .  |.|...| .|.|.  |.|..
agcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 18-287 6.9e-81 264.8 In-house 6-281 (284) alignment 
Range on Protein: 18-287
Range on HMM: 6-281/284.0
KYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEV------PDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLL
| | |..| .|| | .||. .|.  . ...||.|.||||||| ||| |..  |         ...|.|.||.|||| .|.|  | |.|.| ..|||..||
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRQITQVYGFYDECQQKYGNvNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPE-DIEQWQPSP
||||||| . . |||| ||...| . . ..     |  . |.|... |..|.|||.| ..  |.|.  ..| ..||  |  .|| |.||| ..|... ||
rgnhesrpvnmqygfyleckkryse.alyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQ
|||| .||.|   || .   |.|. ||||.|..|| .. |. |||..||| || .  |.|..|...|.|   |....
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 18-69 4.7e-12 38.7 In-house 7-58 (317) alignment 
Range on Protein: 18-69
Range on HMM: 7-58/317.0
KYLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTG
. . |..| .|| | .||. .|     ...||||.||||||| ||| |..  
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldln
subfamily_PPP1C_pd Subfamily PPP1C 19-290 1.8e-102 335.3 In-house 9-280 (282) alignment 
Range on Protein: 19-290
Range on HMM: 9-280/282.0
YLPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESR
 | |.....|... .|.||... .  .. ||.|.||||||..||| ||.|.|  |..||.|.||.||||  |||| . |||.| .||... |||||||| 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

QITQVYGFYDECQQKYGNVnAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPE-DIEQWQPSPRGAGWLF
.|...|||||||...|..   ||  | ||..| |||..| |.|||||||||... |.||| |.| ||.|..|  |||.||||. ....|. . ||  . |
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQAVQ
|..| ..| . | |.||.||||.|..||... .. ||||.|||||| . .| ...||..|.|  .|.|.....
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
PPP_3 20-287 2.1e-119 390.5 In-house 2-270 (271) alignment 
Range on Protein: 20-287
Range on HMM: 2-270/271.0
LPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQ
|.||.||.|....||.| .|||.. ...|||.|||||||..|||||||.||..|.|.|.|.||.||||..|||....||||| .||....||||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECQQKYGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDL-MWSDPEDIEQWQPSPRGAGWLFG
|..||||..|...|.|. . .|....||..|.|||.||.|||.|||||||....||||. ..|. |.|.||...|| ..||||. |....|.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

SKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQ
..||.|| . | |.||.|||.|..|||....|...|||.||||||.|..|...||.|.|.| ..||...
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_PPP3C_pd Subfamily PPP3C 20-279 1.5e-83 274.1 In-house 41-313 (452) alignment 
Range on Protein: 20-279
Range on HMM: 41-313/452.0
LPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQ
| |..  |. |.. .|| .|...  | .|.|..|||||||||||.||. ||.  .|.|.|.||.|||||.|.|.  ||.|||  ||... |||||||.| 
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

ITQVYGFYDECQQKYGnVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPE-DIEQ------WQ-PSPR
.|. . | .||..||.  . .. |.. || | |||..... |||||||||....||.|. . |  |.|. ||.|||.||||  | ..      ..  |.|
lteyftfkeeckikys.eevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvr

GAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFD------NSLVTVWSAPNYCYRCGNVASILSLNENL
|  .... | ..|| . | |  | |||.  ..|||   .       ||.|..|||||.    | |..| ...| 
GcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennv
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 20-288 2.6e-80 262.5 In-house 6-274 (280) alignment 
Range on Protein: 20-288
Range on HMM: 6-274/280.0
LPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQ
. | |.... |..|..|. .. .  | .||..|||.|||. ||| ||.  .  ||.||.|.||.|||| . ||    ||| |.|||... .||||||  .
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

ITQVYGFYDECQQKYGNvNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPE-DIEQWQPSPRGAGWLFG
| . |||.||....| . . ..    ..| | |.|.. |..||.|||||.|...||... . | .. ..|    ||.|.||| ..  |  ..||.  .||
inrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifg

SKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQA
..|  .. .   ..||.| ||.||.|| .. |. ||||.|||.|.    | |..| ..|.|   |.... 
anvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkp
subfamily_PPZ_pd Subfamily PPZ 20-288 8e-78 255.0 In-house 25-293 (300) alignment 
Range on Protein: 20-288
Range on HMM: 25-293/300.0
LPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQ
| .... ..| . .||.| . ..  .  .| | ||.|||. ||| ||   |  | .||.|.||.||||  ||||   ||. | .||... |||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECQQKyGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPEDI-EQWQPSPRGAGWLFG
.|.||||||||...  |.. ||     |. | ||||. ||..|||||||| . ..|.|| ..|  ..|  |   ||.|||| |  ..|.   ||  . . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

SKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQA
     .|    |..|.|||| .|..|| .. | |||||.||||||    |  ...|..| |   |.... 
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 20-278 6.4e-55 179.4 In-house 6-289 (302) alignment 
Range on Protein: 20-278
Range on HMM: 6-289/302.0
LPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEV-----------PDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKI
. ...| .|.| | ||| .|...  . .|||| ||||||| ||. ....  .                .||.||.||||. |.|  . ..|||  || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLLRGNHESRQITQVYGFYDECQQKYGNVN---AWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLE-IPHEGPFCDLMWSDPEDIE
 |||||||.. |   ||| .| ....|. .    |.    || |. |||..  |.||||||.|||...|..|. |.| |. . ..    ||...|| |..
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

QWQ-----P-----SPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNEN
. .     |       ||   .|      .. .  .|.|| |||| . ||.... |. |.|..|||.|     |  ..| .. |
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 20-278 1.1e-54 178.7 In-house 7-290 (302) alignment 
Range on Protein: 20-278
Range on HMM: 7-290/302.0
LPENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEV-----------PDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKI
. ...| .|.| | ||| .|...  . .|||| ||||||| ||. ....  .                .||.||.||||. |.|  . ..|||  || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLLRGNHESRQITQVYGFYDECQQKYGNVN---AWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLE-IPHEGPFCDLMWSDPEDIE
 |||||||.. |   ||| .| ....|. .    |.    || |. |||..  |.||||||.|||...|..|. |.| |. . ..    ||...|| |..
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

QWQ-----P-----SPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNEN
. .     |       ||   .|      .. .  .|.|| |||| . ||.... |. |.|..|||.|     |  ..| .. |
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
PP2Ac_SM00156 21-288 1.5e-105 345.1 In-house 2-269 (271) alignment 
Range on Protein: 21-288
Range on HMM: 2-269/271.0
PENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQI
 ......|.|.|||.| .|.|.  | .|||..||||||..|||.|....||.|...|||.||.||||..|.|. ..|.||| .||.|..||||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECQQKYgNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDP-EDIEQWQPSPRGAGWLFGS
...|||..|...|| . .... ....|. |.|||..| |.||.||||||....||.|| . |. |.|.||...||.|||| .. ...||| ||.. .||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

KVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQA
... || . | |.||.|||..|.|||....|..|||..||||||....|.|..|....||.  .. ...
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 21-287 5.3e-68 222.5 In-house 4-272 (284) alignment 
Range on Protein: 21-287
Range on HMM: 4-272/284.0
PENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQI
| .|.. |  .. ... ..  .  | ||. ||||||||| ||| ||   |    .||.|.||.|||| . |||   |.| |  .|... .||||||   |
ppedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsli

TQVYGFYDECQQKYGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPF-CDLMWSDPEDIE-QWQPSPRGAGWLFG
 ..||||.|||..| .   ..    ||  . |.|..  ..||.|||.|  .. . |.| | | .. |    .  |..|||| ...  |.|  ||  ..||
nkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfg

SKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQ
|    ..     ..|. ||||.||.|| .. .  |||..||| || .  | |... .|.||   | ...
sdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlr
PPP_1 22-274 1.6e-110 361.5 In-house 3-263 (264) alignment 
Range on Protein: 22-274
Range on HMM: 3-263/264.0
ENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQIT
|. |..|....|||| .|.|.. |....|.||||||||.|||.|||.||..|.|||.|.||.||||..|.|....||||| .||....||||||||||.|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

QVYGFYDECQQKYGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDL--------MWSDPEDIEQWQPSPRGA
.||||..|...|... . .|..| |||.|.|||.||.|.|.|||||||....|||||...|. |.|.||..|||        ...|.|. |... |.|||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILS
|.|||..||..| . |.|.||.|||....|||........||..||.||.....| .....
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 22-286 7.6e-76 248.0 In-house 10-274 (281) alignment 
Range on Protein: 22-286
Range on HMM: 10-274/281.0
ENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQIT
.......   |. .. ||...  . .|... ||.|.|| || .||.  | ||.. .||.||.||||  |||..  |..|| ||.|.| |||||||  .. 
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

QVYGFYDECQQKYGnVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPED-IEQWQPSPRGAGWLFGSK
..|||| ||. ||| .. |    . |. | ..| |. .|||.||||||.. .||..| . . .. .. |   ||.|.||..  |.|. | ||....|| .
kiygfyvecvtkyG.eelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGkn

VTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIF
|  .     ...|| ||||.||.||. .    |.||.|.||||    | |..| ..|.|. ... .
vvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislval
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 22-285 3e-72 235.9 In-house 12-278 (287) alignment 
Range on Protein: 22-285
Range on HMM: 12-278/287.0
ENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQIT
..|. .. |...|.|   . .  |..|.||.||||||. ||| .|.  |  |...|.|.||.||||  |||   .|..|| .|| |. ||||||| ..| 
dkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkin

QVYGFYDECQQKYGnVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNL-E-IPHEGPFCDLMWSDPE-DIEQWQPS-PRGAGWLF
..|||..| ..|..  . .|    ||. |.| |... ..||.|||.|||...||... ...   .   .||   ||.|.||| | .  ..   |.   .|
klyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvf

GSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKI
| |.  .. .  ...|| |||....||| ..||. ||||.||| |. .  |..... ... |.  |  
GkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvv
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 22-285 6.2e-64 208.8 In-house 18-285 (290) alignment 
Range on Protein: 22-285
Range on HMM: 18-285/290.0
ENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQIT
..|. .. |...|.|     .  | .|..| ||||||. .||. |.  |  |. ...|.||.||||  |||   .|. .| ||. |. ||||||| |.. 
dkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvn

QVYGFYDECQQKYGnVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRN--LEIPHEGPFCDLMWSDPED--IEQWQ-PSPRGAGWL
..|||..|  .| |  . ||    ||. |.| | .. |.||.|||.|.|. . . .. . .       .||   ||.|.||.    .  .    |.   .
rlygfkeelarkrg.srlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvv

FGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKI
|| |.  .. .  .|.|| |||.. .||. ..||. ||||.||| |. .  |. .|. . | |.  . .
fgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 22-68 6.1e-08 25.1 In-house 13-59 (339) alignment 
Range on Protein: 22-68
Range on HMM: 13-59/339.0
ENDLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKT
  .| .|| | .||.  |  .  . .|. . ||||||| ||| ..  
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldm
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 24-284 6.2e-69 225.5 In-house 10-270 (280) alignment 
Range on Protein: 24-284
Range on HMM: 10-270/280.0
DLKKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQITQV
..  .   |. ...||||.    .|. . |||| |. |.  ||   | ||. . .|.||.||||   .| .  |..|| || |.| |||||||.  . ..
eiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki

YGFYDECQQKYGnVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPED-IEQWQPSPRGAGWLFGSKVT
|||| ||| ||| |  |    |.|. . ....|  .|||.||||||..  || || | |  |    | . ||.|||| .  | |  | ||  ..||  | 
ygfyvecqykyg.vglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvv

AEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFK
 .  .   ..|| ||||.||.||  |    |.||.| |||| .  | |... || ||.  |.
eqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfq
subfamily_PPPLV_pd Subfamily PPPLV 26-279 1.4e-52 171.8 In-house 3-280 (290) alignment 
Range on Protein: 26-279
Range on HMM: 3-280/290.0
KKLCERVKELLLEESNVQPVRSPVTICGDIHGQFYDLL----ELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQIT
  ||.   . |..| .. ...||. . ||.||.. ||      |..|| ..  ....|.||.|||| .|.|  .||||||  || |. ||||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECQQKYGNV--NAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQI---RIISRNLEIPHEGP--FCDLMWSDPEDIE-------Q--
. . .. |.. |.|.   ..|.  ..|||.| |||.|| ||.|||.|.   . |  .|   . |  .|. . .|     |..||||.. .       .  
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

----WQPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENL
     . . || | .|...    | . |.|. . |||.  ..|.|.  .  |.||.|. .||    . | ||  ...|
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvdkkkl
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 37-287 3.8e-58 190.1 In-house 37-290 (307) alignment 
Range on Protein: 37-287
Range on HMM: 37-290/307.0
LEESNVQPVRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQITQVYGFYDECQQKYGN
  |  .  .  |. . ||.|||| ||...|   |  |.| ||| ||.||||  |||.   |.. |  ||..| |||||||  .. . ||||.||     .
ssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipk

--VNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDLMWSDPED-IEQWQPSPRGAGWLFGSKVTAEFEHINGLNL
   . |     .|. | ..|.|  |.||.|||||| .  ||..|   . .  |  |   |..|.||.  . .|. | ||.|. ||..|  .  .  |..|
cgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgvel

ICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQ
| ||||.. .||  .    |.|..||| ||    |   .| ..| |  .   | 
iirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafv
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 45-284 1.6e-56 184.9 In-house 5-251 (263) alignment 
Range on Protein: 45-284
Range on HMM: 5-251/263.0
VRSPVTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQITQVYGFYDECQQKYGNVNA----W
...|. |||| |||. ||| .|.. |    |.|.|.||.|||| .|||    |..||   | |. ||||||| . | . |||. | ....   .     .
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

KYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPF-CDLMWSDPE-DIEQWQPSP-RGAGWLFGSKVTAEFEHINGLNLICRA
..   || .. |.||.  ..||.|||.||....||.|| |   ||  .  |. |||.|.||| | . ..|   |    .|| |   .. .   ..|| ||
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivra

HQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFK
||.|. || .. |  |.||.||  |     | |... .|. |.  | 
hqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfv
Metallophos Calcineurin-like phosphoesterase 48-240 1.5e-45 148.9 Pfam-A 2-198 (200) alignment 
Range on Protein: 48-240
Range on HMM: 2-198/200.0
PVTICGDIHGQFYDL----LELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYL--LALKARYPDKITLLRGNHESRQITQVYGFYDECQ----------
.....||.||...||    |.|.| ..| . ....|.||.|||| .|.||. .|  |.|| ..|... ||||||||......|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------QKYGNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIriisrnleiphegpfcdlmwsdpedieqwqp
                        .... .|. ..  .|..| |.|..|||.|..||.||.   . |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGWLFGSKVTAEFEHINGLNLICRAHQL
    ...|||.... ...  .|. |..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 49-240 9.4e-82 266.5 In-house 1-197 (198) alignment 
Range on Protein: 49-240
Range on HMM: 1-197/198.0
VTICGDIHGQFYDLLELFKTGGEVPDTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQITQVYGFYDECQQKYGNVNAWKYCTSVFD
||.|||.|||..|||.|||.|...|...|.|.||.||||..|||....||||| .||....||||||||.....||||..|...|.|. ...|....||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

FLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIPHEGPFCDL-----MWSDPEDIEQWQPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQL
.|.|||.||.|||.||||||.....||||. ..|. |.|.||...||     .....|. |....| ||||.|||..||.|. . | |.||.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 49-240 6.6e-77 251.0 In-house 1-196 (197) alignment 
Range on Protein: 49-240
Range on HMM: 1-196/197.0
VTICGDIHGQFYDL-LELFKTGGEVP-DTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQITQVYGFYDECQQKyGNVNAWKYCTSV
||..||||||..|| |.|.|.||. . ...|||.||.||||..|||....||||| .||....||||||||......|||..|...|  . ...|... |
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIP-HEGPFCDL-MWSDPE-DIEQWQPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQL
||.|.|||.||.|||.||||||.....||.|. |.|. |.| .|. ..|| .||||. . |....| ||||.|||..|| .| . |.|.||.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 49-240 1.4e-75 246.7 In-house 1-198 (199) alignment 
Range on Protein: 49-240
Range on HMM: 1-198/199.0
VTICGDIHGQFYDL-LELFKTGGEVP-DTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQITQVYGFYDECQQKYGNVNAWKYCTSV
||.|||.|||..|| |.|||.||. . ...|||.||.||||..|||....||||| .||....|||||||..|....|||..|...||.. ...|... |
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDFLTLAAIIDGKVLCVHGGLSPKVRTLDQIRIISRNLEIP-HEGPFCDL-MWSDPE-DIEQ-WQPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQL
||.|.|||.||.|||.|||||||......... | |. ||| ..|  .|| .||||. . |. ...| ||||.||| .|| .| . |.|.||.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 50-120 5.7e-08 25.5 In-house 13-79 (235) alignment 
Range on Protein: 50-120
Range on HMM: 13-79/235.0
TICGDIHGQFYDLLELFK--TGGEVPDTNYVFMGDFVDRGYYSLETFTYLlalkarYPDKITLLRGNHESRQI
 . ||.|| . .|.||..  .||  ..   |..||....|  |.|.  |.        |.   ..||||   .
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 74-288 2e-70 230.4 In-house 100-314 (317) alignment 
Range on Protein: 74-288
Range on HMM: 100-314/317.0
DTNYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQITQVYGFYDECQQKYGnVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRT
  .|.|.||.|||| .|.|  . |.||| .||||..||||||||| . . |||| |....|  .. ..    .|  | |.|... |.||.|||.| ..  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrys.aalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDQIRIISRNLEIPHEGPFCDLMWSDPE-DIEQWQPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASI
|.|.  . | |.||  |  .|| |.||. .......|.|||| .||.|   || .   |.|. ||||.|..|| .. |  |||..|||.|| .  |.|..
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

LSLNENLDRDFKIFQA
||....|   ..... 
lsvdkklkisinvlrp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 76-288 8.1e-55 179.2 In-house 121-333 (339) alignment 
Range on Protein: 76-288
Range on HMM: 121-333/339.0
NYVFMGDFVDRGYYSLETFTYLLALKARYPDKITLLRGNHESRQITQVYGFYDECQQKYgNVNAWKYCTSVFDFLTLAAIIDGKVLCVHGGLSPKVRTLD
 |.|.||.|||| .|.|    | |||  |||.| ||||||||| .   |||| | . .| . . ..    .|. . ..|.|.  ..|.|||.| .. ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRIISRNLEIPHEGPFCDLMWSDPEDIEQ-WQPSPRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILS
|. .. | ||||  | . || |.||.  |. ..|| ||| ..||      | .   |... | ||.|..|| ..    |||..|||||| .  | |...|
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LNENLDRDFKIFQA
....|    ..|. 
idkklkisinvfrp
subfamily_PPP7C_pd Subfamily PPP7C 193-299 1.6e-17 56.3 In-house 238-345 (383) alignment 
Range on Protein: 193-299
Range on HMM: 238-345/383.0
CDLMWSDPEDIEQWQPS-PRGAGWLFGSKVTAEFEHINGLNLICRAHQLVQEGYRYMFDNSLVTVWSAPNYCYRCGNVASILSLNENLDRDFKIFQAVQE
 |..||||.  |  .|   ||.|  ||. ||... .  .|.|. |.|.  .||| .. |. ..|..|| ||     |  . . |...|   .  .|| ..
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqaska

ERNIPTRP
..... | 
tkkltlrq