Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PFKFB_pd | Subfamily PFKFB | 19-90 | 5.9e-08 | 24.4 | In-house | 4-68 (198) | alignment | ||
Range on Protein: 19-90
Range on HMM: 4-68/198.0
ISKKKVYFIRHGQSTFNIAYLANNKVDpylfdarLTEEGEKQANELSENVE-KYLQDVeLIISSPLTRALCTT
......|. |||.| | . . |||.|...|..|.. .. . |... . .| | |. |.
lkpreiylvRhGeseknkkgriggdse.......LterGveyakklakfikeenlkel.rvwtselkrtiqTa
|
|||||||||
0051064 | Phosphoglycerate mutase-like | 21-220 | 8.3e-26 | 83.8 | In-house | 3-213 (241) | alignment | ||
Range on Protein: 21-220
Range on HMM: 3-213/241.0
KKKVYFIRHGQSTFNIAYLANNkvdpYlFDARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTRRGFGKFlkE-NsNIKCLVSPLHSETvITS
|..|..|||.|..| . . . . .|. |||.|..|| .| | ... ......||||.||. | . .. . ... | | |
mkrlyLvRHGesewnaegrlqg....w.tDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaeal..glp.llpvvvdprlrEi.dfg
DDNGRPRSIIEKENPDFNFGDLQERWWYLPSS--IKDDLSIDTELYFKTN-----GYKEPIESILHRIEEFKKFLLSR---NESTIAVVGHSDFFYHFFD
.. |.... |... |.. . |.. ....| . |.|.. ..|.... . |... . .|.... . ||.| ......||.|. . ...
alegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggviralla
RSIP---------HMKNCQI
. . ...|...
yllglpleellrlnlpngsv
|
|||||||||
0049178 | Phosphoglycerate mutase-like | 21-220 | 2.4e-21 | 68.9 | In-house | 3-211 (243) | alignment | ||
Range on Protein: 21-220
Range on HMM: 3-211/243.0
KKKVYFIRHGQSTFNIAYLANNkvdpyLFDARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTRRGFGKFlkENSNIKCLVSPLHSETVITSD
....|..|||....| . . . .|. |||.|..|| .| | .. ......||||.||. | . .. . .... |.| | .
mtrlyLvRHGetewnaegrlqg.....wtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiileal..glpllpvvvdprLrErdfGal
DnGRPRSIIEKENPDFNFGDLQERWWYLP-SSIKDDLSIDTELYFKTN----GYKEPIESILHRIEEFKKFLLSR---NESTIAVVGHSDFFYHFFDRSI
. |.... |... |. . .. ... | . .|| ... .. . |. . .. |.... . || . ...|..||.|. .. . .
e.gltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalll
P---------HMKNCQI
...|. .
glpleellrlnlpngsv
|
|||||||||
0043909 | Phosphoglycerate mutase-like | 21-228 | 2.7e-21 | 68.6 | In-house | 2-224 (249) | alignment | ||
Range on Protein: 21-228
Range on HMM: 2-224/249.0
KKKVYFIRHGQSTFNIAYLANNkvdpyLFDARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTRRGFGKFlkENSNIKCLVSPLHSETVITSD
.|..|..|||....| . . . .|. |||.|..|| .| | . .. .....||||.||. | . .. . ...... |.| | .
mkrlyLvRHGetewnaegrfqg.....wlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileel..gldklpvevdprLrErdfGal
DnGRPRSIIEKEnpdfnFGDLQERWWY----------------LPSSIKDDLSIDTELYFKTNGYKEPIESILHRIEEFKKFLLSR---NESTIAVVGHS
. |.. . |... ..... .|.. |. ..| . .|..... . |... ...|.... . || | .......|.|.
e.gltkaeiaek.....ypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHg
DF----FYHFFDRSIP-----HMKNCQIVSWCSETN
. .......|.. ...|. |. . . .
gvlrallayllglsledilrlnlpngsitvlelddg
|
|||||||||
subfamily_Dicty-HP1-1_pd | Subfamily Dicty-HP1-1 | 22-229 | 2.9e-127 | 412.6 | In-house | 1-210 (210) | alignment | ||
Range on Protein: 22-229
Range on HMM: 1-210/210.0
KKVYFIRHGQSTFNIAYlaNNKVDPYLFDARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTRRGFGKFLKENSnIKCLVSPLHSETVITSDD
||||.||||.||||.|| |.|||||||||||||||.||||||||||||.||||||.|||||||||.||.....|.|||.| ||||||.||.|..|||||
kkvyiirhgestfnkay..nekvdpylfdarlteegkkqanelsenvekllqdvelvisspltraldttkiallkllkeks.ikclvsslhrellitsdd
NGRPRSIIEKENPDFNFGDLQERWWYLPS-----SIKDDLSIDTELYFKTNGYKEPIESILHRIEEFKKFLLSRNESTIAVVGHSDFFYHFFDRSIPHMK
|||..||||||.|.|.|..||||.||||. ..|||||||||||||..||||.|||.|.|.|||||||||||||.||||||.||||.|.||||.|.|
ngrvksiiekeypefdfsllqerrwylpeleelielkddlsidtelyfkkigykesiesllkrveefkkfllsrnessiavvghadffyyftdrsilhlk
NCQIVSWCSETNE
|||.|....|..|
ncqvvklnlelse
|
|||||||||
0048955 | Phosphoglycerate mutase-like | 22-208 | 8.8e-26 | 83.7 | In-house | 1-189 (240) | alignment | ||
Range on Protein: 22-208
Range on HMM: 1-189/240.0
KKVYFIRHGQSTFNIAYLANNkvdpYlFDARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTRRGFGKFlkE-NSnIKCLVSPLHSETvITSD
...|..|||.|..| . . . . .|. |||.|..|| .| | .. ...|..||||.||. | . .. . . .. | | | .
prlyLvRHGesewnaegrlqg....w.tDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaeal..glpl.lpvvvdprlrEr.dfga
DNGRPRSIIEKENPDFNFGDLQERWWYLPSSI--KDDLSIDTELYFKTN-----GYKEPIESILHRIEEFKKFLLSR---NESTIAVVGHSDFFYHFF
. |.... |... |.. . |.. ....| . |.|.. ..|.... . |... . |.... . ||.| ......||.|. . ...
legltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirall
|
|||||||||
0036777 | Phosphoglycerate mutase-like | 22-228 | 9.4e-24 | 76.8 | In-house | 3-220 (247) | alignment | ||
Range on Protein: 22-228
Range on HMM: 3-220/247.0
KKVYFIRHGQSTFNIaylaNNKVDPYlFDARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTRRGFGKFlkENSNIKCLVSPLHSEtVITSDD
|..|..|||....|. .... .|. |||.|..|| .| | . .. .....||||.||. | . .. . ..|... |.| | . .
krlyLvRHGetewna....egrfqgw.lDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiileal..glsllpvvvdprLrE.rdyGal
NGRPRSIIEKENPDFNFGDLQERWWYLP-------SSIKDDLSIDTELYFKTNGYKEPIESILHRIEEFKKFLLSR---NESTIAVVGHSDFFYHFFDRS
.|.... |... |.. . .. ..| | . .|| ... |.... . |... ...|.... . || | ......||.|. . .. .
egltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayl
IP---------HMKNCQIVSWCSETN
...|. |. . . .
lglsledilrlnlpngsitvlelddd
|
|||||||||
0036887 | Phosphoglycerate mutase-like | 22-221 | 3.5e-21 | 68.2 | In-house | 2-181 (202) | alignment | ||
Range on Protein: 22-221
Range on HMM: 2-181/202.0
KKVYFIRHGQSTFNIAYLANNkvdpYlFDARLTEEGEKQANELSENVEkyLQDVELIISSPLTRALCTTRRGFGKFlkensNIKCLVSPLHSEtVITSDD
...|..|||....|.. . . . .|. |||.|..|| .| | . .. ...||||.||. | . .. . .... | | | . ..
trlyLvRHGetewnvegrlqg....d.ldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaeal.....glpvivdprlrE.idfgal
NGRPRSIIEKENPDFNFGDLQERWWYLPSSIkddlsidtelyfktngykEPIESILHRIEEFKKFLLSR-NESTIAVVGHSDFFYH----FFDRSIPH--
.|.. . |... |.. . |. ... |. |... ...|.... . || | ......||.|. . ....|. .
egltleeiaekypeelaawlrdpydfrppgg..................EsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledll
----MKNCQIV
..|. ..
rlrklpngsvt
|
|||||||||
0037864 | Phosphoglycerate mutase-like | 22-209 | 4.2e-20 | 64.5 | In-house | 8-172 (211) | alignment | ||
Range on Protein: 22-209
Range on HMM: 8-172/211.0
KKVYFIRHGQSTFNIAYLANNkvdpyLFDARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTRRGFGKFlkENSNIKCLVSPLHSEtVITSDD
...|..|||....|.. . . .|. |||.|..|| .| | . .. ......||||.||. | . .. . ..... |.| | . .
trlyLvRHGetewnaegrlqg.....wldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiileal..glpllpvevdprlrE.rdfgal
NGRPRSIIEKENPDFNFGDLQERWWYLPSSIkddlsidtelyfktngykEPIESILHRIEEFKKFLLSR---NESTIAVVGHSDFFYHFFD
.|.. . |... |. . |. ... |. |.......|.... . || | ..... ||.|. . ..
egltleeiaekypeelvawlrdpydfrppgg..................EsladvvaRvlpaleellarllkdgenvlvVsHggvlralla
|
|||||||||
0053607 | Phosphoglycerate mutase-like | 22-220 | 2e-19 | 62.3 | In-house | 2-172 (191) | alignment | ||
Range on Protein: 22-220
Range on HMM: 2-172/191.0
KKVYFIRHGQSTFNIAYLANNkvdpylfDARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTRRGfgkflkensNIKCLVSPLHSETVItSDD
...|..|||....| . . |. |||.|..|| | | .. .. ...||||.||. | . ... | | | |
trlyLvRHGetewnaegrlqg.......dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.........glpvevdprlrEidf.gdw
NGRPRSIIEKENPDFNFGDLQERWWYLPssikddlsidtelyfktnGYKEPIESILHRIEEFKKFLLSrnESTIAVVGHSDFFYHFFDRSIP--------
.|.... .... |. . |. ..| | |... ...|.... . ||. .....||.|. . . .
egltleelaekypeelaawlrdpldyrp..................pggEsladvaaRvlpaleella..ggnvlvVaHggvirallayllglpleellr
-HMKNCQI
...|. .
lnlpngsv
|
|||||||||
0035570 | Phosphoglycerate mutase-like | 23-223 | 1.9e-20 | 65.7 | In-house | 1-173 (219) | alignment | ||
Range on Protein: 23-223
Range on HMM: 1-173/219.0
KVYFIRHGQSTFNIAYLANNkvdpylfDARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTRRGfgkflkensNIKCLVSPLHSETVITSDdN
..|..|||....|.. . . |. |||.|..|| .| | .. .. ...||||.||. | . ... ..| | . .
rlyLvRHGetewnlegrlqg.......dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.........glpveidprLrEidfgdl.e
GRPRSIIEKENPDFNFGDLQERWWYLPssikddlsidtelyfktnGYKEPIESILHRIEEFKKFLlsRNESTIAVVGHSDFFYHFFDRS----IP-----
|.... |... |. . |. ..| | |... . .|.... . | .......||.|. . .. . .
gltldeiaekypeelaawlrdpydyrp..................pggEsladvvaRvlpaleel..edgenvlvVsHggvirallayllglpleeilrl
HMKNCQIVSW
...|. .. .
nlpngsvtvl
|
|||||||||
0039931 | Phosphoglycerate mutase-like | 23-221 | 2.7e-20 | 65.2 | In-house | 1-171 (219) | alignment | ||
Range on Protein: 23-221
Range on HMM: 1-171/219.0
KVYFIRHGQSTFNIAYLANNkvdpylfDARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTRRGfgkflkensNIKCLVSPLHSETVITSDdN
..|..|||....| . . |. |||.|..|| .| | .. .. ...||||.||. | . ... . | | . .
rlyLvRHGetewnvegrlqg.......dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.........glpveidprLrEidfgdl.e
GRPRSIIEKENPDFNFGDLQERWWYLPssikddlsidtelyfktnGYKEPIESILHRIEEFKKFLLSrnESTIAVVGHSDFFYHFFDRSIP---------
|.. . |... |. . |. ..| | |... . .|.... . ||. .....||.|. . .. .
gltleeiaekypeelaawlrdpydyrp..................pggEsladvvaRvlpaleella..genvlvVsHggvirallayllglsleeilrl
HMKNCQIV
...|. ..
nlpngsvt
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 23-203 | 3e-18 | 59.2 | Pfam-A | 1-154 (158) | alignment | ||
Range on Protein: 23-203
Range on HMM: 1-154/158.0
KVYFIRHGQSTFNIAYLANNKVDpylfdARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTRRgFGKflkeNSNIKCLVSPLHSETVITSDDn
..|..|||.| .| . .. . | . |||.|..||.|| . .. . .. ...|||.||. |.. . . . .|. .| | . . .
rlylvRHGesewnkegrlqgwsd.....vpLtekGreqarelgkkLkradlpidavytSplkRaiqTaei.lle....eldipiikeprLrerdfgewe.
GRPRSIIEKENPdfnfgDLQERWWYLPSSIKDDlsidtelyfktngYKEPIESILHRIEEFKKFLL--SRNESTIAVVGHSDF
|.|.. ...| | . .|.|. . ... . .| . . |...| . |. ... .. .|.| .
glpkeevkeefp.....eeyekwkrdkkefrpp.............egesladvyeRvapfleelieakdkgenvlivsHggv
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 23-203 | 3e-18 | 59.2 | In-house | 1-154 (158) | alignment | ||
Range on Protein: 23-203
Range on HMM: 1-154/158.0
KVYFIRHGQSTFNIAYLANNKVDpylfdARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTRRgFGKflkeNSNIKCLVSPLHSETVITSDDn
..|..|||.| .| . .. . | . |||.|..||.|| . .. . .. ...|||.||. |.. . . . .|. .| | . . .
rlylvRHGesewnkegrlqgwsd.....vpLtekGreqarelgkkLkradlpidavytSplkRaiqTaei.lle....eldipiikeprLrerdfgewe.
GRPRSIIEKENPdfnfgDLQERWWYLPSSIKDDlsidtelyfktngYKEPIESILHRIEEFKKFLL--SRNESTIAVVGHSDF
|.|.. ...| | . .|.|. . ... . .| . . |...| . |. ... .. .|.| .
glpkeevkeefp.....eeyekwkrdkkefrpp.............egesladvyeRvapfleelieakdkgenvlivsHggv
|
|||||||||
0050036 | Phosphoglycerate mutase-like | 23-207 | 1.1e-13 | 43.4 | In-house | 2-140 (171) | alignment | ||
Range on Protein: 23-207
Range on HMM: 2-140/171.0
KVYFIRHGQSTFNIAYLANNKvdpylFDARLTEEGEKQANELSENVekylqDVELIISSPLTRALCTTRRGFgkflkensnikclvsplhsetvitsddn
..|..|||....|.. . . | |||.|..|| | | .. ...||||.|| | . .
rlyLvRHGetewnlegrfqgw.....tdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil............................
grPRSIIEKENPDFNFGDLQERWWYLPSSIKDDlsIDTELYFKTNGYKEPIESILHRIEEFKKFLLsrneSTIAVVGHSDFFYHF
.. |.... ...||... . . . ... |.. . |... |.|. .. . || ....||.|. . .
..lpvivdprLrErdfGawegltldeiaakype..wlldlldlappggEsladvlaRvlpaleell....gnvlvvaHggviral
|
|||||||||
subfamily_PGAM_pd | Subfamily PGAM | 23-91 | 1.1e-08 | 26.6 | In-house | 2-65 (248) | alignment | ||
Range on Protein: 23-91
Range on HMM: 2-65/248.0
KVYFIRHGQSTFNIaylaNNKVDPYlFDARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTR
|. ..|||.|..| .|| . .||.|.|.|...|..... ... ..... .| |.|| |..
klvllRhGeselnk....enkfcgw.vDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTle
|
|||||||||
subfamily_TFC7_pd | Subfamily TFC7 | 23-91 | 9.4e-07 | 19.6 | In-house | 2-71 (255) | alignment | ||
Range on Protein: 23-91
Range on HMM: 2-71/255.0
KVYFIRHGQSTFNIAYLANNKVD-PYLFDARLTEEGEKQANELSENVEKYLQDVELIISSPLTRALCTTR
..| ||| . . .. |. |.|.| .||.||.. ..| . |.|.|||| | | |..
tiyiarhGyrsnwlpkgpypdpltgidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletsk
|
|||||||||
subfamily_TIGAR_pd | Subfamily TIGAR | 24-91 | 3e-09 | 28.8 | In-house | 3-63 (222) | alignment | ||
Range on Protein: 24-91
Range on HMM: 3-63/222.0
VYFIRHGQSTFNIAYLANNKvdpylFDARLTEEGEKQANELSENVEKylQDVELIISSPLTRALCTTR
.. .|||.. || . . | |.|.|..|| ... .. . ...|.||.| || |.
livVrhGetefnkekilqgq.....tdtpLsekGveQakrvakrLsn..ekinyifsSdllRAkqTae
|
|||||||||
subfamily_PMU1_pd | Subfamily PMU1 | 27-216 | 6.5e-09 | 25.8 | In-house | 20-218 (233) | alignment | ||
Range on Protein: 27-216
Range on HMM: 20-218/233.0
IRHGQSTFNIA-YLANNKVDPYLFDARLTEEGEKQANELSENV----EKYLQDVELI-ISSPLTRALCTTRRGFGKFLKE------NSNIKCLVS-PLHS
...| ... | .... . |..|| |. |. . || | | .| . ||.| ||| | .| | | .... . |
lkyGmekldaywallsgdengeildskltslGkdqvrrtGsnvllpmakqlGmlehvffsstlrraletalesfeavlaetqelpagtkvstriieslre
ETVITSDDNGRPRSIIEKENPDFNFG-DLQERWWYLPssikdDLSIDTELYfKTNgYKEPIESILHRIEEFKKFLL---SRNESTIAVVGHSDFFYHFFd
.. |. . ||.| .| .|.. .| |.| || | ||. ||. ..|. . .| . . |. | .| .|.| || .. .
tlGshtcdkrvarsaivdeyqdlslesghtvhwqyvP.....dlPeddelw.ktd.hretkveldkrtlatlfelaadlsseekfvalvthssvllsll.
RSIPHMK
|.. |..
raldhlr
|