Gene DDB_G0280831 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP084_AA protein Get Run
DdisP084_AA_256-466 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PFKFB_pd Subfamily PFKFB 257-467 1.7e-65 212.2 In-house 6-191 (198) alignment 
Range on Protein: 257-467
Range on HMM: 6-191/198.0
PYELVLVRHGQSEGNeaqarsKRGDLSAYTEefkkkhssvyrLTDKGVLQAKIAGKWVR-ENISEVfdRYYTSEYVRAMETASLLGLPDADWLTeiqLRE
|.|..|||||.|| |      |.|......|           ||..|| .||...|... ||..|.  |..|||..|...||.|||||...| .   |.|
preiylvRhGesekn......kkgriggdse...........LterGveyakklakfikeenlkel..rvwtselkrtiqTaellglpkeqwka...Lde

RDKGKMDNISWTDKKDHFGNEMMMRKRDSFFWCPPGGESIANICQRVEHTFITLRRECSNkrVIIVAHGEIMwafRVRLERLSQLRFHQLQSSDDPRDQI
.|.||.|.......|..|..|...||.|......|.|||.....||.|.....|.||..|  |.|.|| ...   ||.|..|.......|.....|....
ldaGkcdgltyeeikekfpeefkerkkdkyryryprgEsyedlvqRlepvileLereqen..vliiaHqavl...rvllaylldksaeelpylkvplhtv

HNTTILHY-SRIH
...|...| ....
ikltpvaYgckve
0037864 Phosphoglycerate mutase-like 257-445 3.2e-37 120.3 In-house 7-185 (211) alignment 
Range on Protein: 257-445
Range on HMM: 7-185/211.0
PYELVLVRHGQSEGNEAQARSKrgdlsayteefkkkhSSVYRLTDKGVLQAKIAGKWVRENiSEVFDRYYTSEYVRAMETASLL----GLPDADWLTEIQ
.. |.|||||..| | ..                    . . ||..|. ||. .|......    ||..|.| ..||..|| ..    |||  .. .. .
mtrlyLvRHGetewnaegrlqg...............wldvpLtelGreqaralgealadl.glpfdavysSpllRaiqTaeiilealglpllpvevdpr

LRERDKGKMDNISWTDKKDHFGNEMMMRKRDSFFWCPPGGESIANICQRVEHTFITLRREC--SNKRVIIVAHGEIMWAFRVRLERLSQLRFHQL
||||| | ........ ..... |. .. ||.....||||||.| ...||.... .|....  ....|..|.|| ...|.  .|  ||   ...|
lrErdfgalegltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrl
0036777 Phosphoglycerate mutase-like 258-464 1.6e-37 121.8 In-house 3-216 (247) alignment 
Range on Protein: 258-464
Range on HMM: 3-216/247.0
YELVLVRHGQSEGNEaqarskrgdlsayteefKK---KHSSvYRLTDKGVLQAKIAGKWVRENiSEVFDRYYTSEYVRAMETASLL----GLPDADWLTE
. |.|||||..| |                   .    ..    ||..|. ||| .|....|.    ||..|.| ..||..|| ..    ||.  .  ..
krlyLvRHGetewna.................egrfqgwlD.vpLtelGreqakalgellkel.glpfdavysSpllRAiqTaeiilealglsllpvvvd

IQLRERDKGKMDNISWTDKKDHFGNEMMMRKRDSFFWCP-------------------------PGGESIANICQRVEHTFITLRRE--CSNKRVIIVAH
  ||||| | ... .... ..... |. .. ||.... |                         |||||.| ...||. ..  |...   ....|..|.|
prLrErdyGalegltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsH

GEIMWAFRVRLERLSQLRFHQLqssddprdQIHNTTILHYS
| ...|.  .|. ||   .. |        .. |..|... 
ggvlrallayllglsledilrl........nlpngsitvle
0049178 Phosphoglycerate mutase-like 258-445 2.4e-37 121.2 In-house 4-204 (243) alignment 
Range on Protein: 258-445
Range on HMM: 4-204/243.0
YELVLVRHGQSEGNEAQARSKrgdlsayteefkkkhSSVYRLTDKGVLQAKIAGKWVRENiSEVFDRYYTSEYVRAMETASLL----GLPDADWLTEIQL
..|.|||||..| | ..                    . . ||..|. ||. .|.. .|.    ||. |.| . ||..|| ..    |||  .  .. .|
trlyLvRHGetewnaegrlqg...............wtDspLtelGreqAralgellael.glkfdavysSplkRaiqTaeiilealglpllpvvvdprL

RERDKGKMDNISWTDKKDHFGNEMMMRKRDSFFWCP-----------------------PGGESIANICQRVEHTFITLRRE--CSNKRVIIVAHGEIMW
|||| | ........ ......|. .. ||.....|                       ||||| | ...||.... .|..|   ..|.|..|||| ...
rErdfGalegltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvir

AFRVRLERLSQLRFHQL
|.  .|  |.  ....|
allalllglpleellrl
0043909 Phosphoglycerate mutase-like 258-463 6.6e-37 119.7 In-house 3-219 (249) alignment 
Range on Protein: 258-463
Range on HMM: 3-219/249.0
YELVLVRHGQSEGNEAqarskrgdlsayteefkKK---HSSvYRLTDKGVLQAKIAGKWVRENiSEVFDRYYTSEYVRAMETASLL----GLPDADWLTE
..|.|||||..| | .                 ..   ..    ||..|. ||. .|....|.    ||. |.| ..||..|| ..    ||.  .. ..
krlyLvRHGetewnae.................grfqgwlD.spLtelGreqaralgealkel.gipfdavysSplkRAiqTaeiileelgldklpvevd

IQLRERDKGKMDNISWTDKKDHFGNEMMMRKR-----------------------------DSFFWCPPGGESIANICQRVEHTFITLRRE--CSNKRVI
 .||||| | ........ ..... |.....|                             |.....||||||.| ...||....  |...   ....|.
prLrErdfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvl

IVAHGEIMWAFRVRLERLSQLRFHQLqssddprdQIHNTTILHY
||||| ...|.  .|  ||   ...|        ...|..|...
iVaHggvlrallayllglsledilrl........nlpngsitvl
0036887 Phosphoglycerate mutase-like 258-446 4.7e-36 116.6 In-house 2-173 (202) alignment 
Range on Protein: 258-446
Range on HMM: 2-173/202.0
YELVLVRHGQSEGNEAQARSKrgdlsayteefkkkHSSvYRLTDKGVLQAKIAGKWVReniSEVFDRYYTSEYVRAMETASLL----GLPdadWLTEIQL
. |.|||||..| | ..                  ..  . ||..|. ||. .|....      ||..|.| ..||..|| ..    |||   . .. .|
trlyLvRHGetewnvegrlqg..............dld.vpLtelGreqaralgerla...glpfdavysSpllRaiqTaeiiaealglp...vivdprl

RERDKGKMDNISWTDKKDHFGNEMMMRKRDSFFWCPPGGESIANICQRVEHTFITLRRECSNKRVIIVAHGEIMWAFRVRLERLSQLRFHQLQ
||.| | ........ ..... |. .. ||.....||||||.| ...||.... .|........|..|.|| ...|.  .| .||  ... | 
rEidfgalegltleeiaekypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlr
0051064 Phosphoglycerate mutase-like 258-464 6.9e-36 116.7 In-house 4-217 (241) alignment 
Range on Protein: 258-464
Range on HMM: 4-217/241.0
YELVLVRHGQSEGNEAQARSKrgdlsayteefkkkHSSvYRLTDKGVLQAKIAGKWVRENiSEVFDRYYTSEYVRAMETAS----LLGLPDADWLTEIQL
..|.|||||.|| | ..                  ..    ||..|. ||. .|.. ...    ||..|.| . ||..||      ||||. .  .. .|
krlyLvRHGesewnaegrlqg..............wtD.vpLtelGreqaralgerladl.gikfdavysSpllRaiqTaeiiaealglpllpvvvdprl

RERDKGKMDNISWTDKKDHFGNEMMMRKRDSFFWCP-------------------------PGGESIANICQRVEHTFITLRRE--CSNKRVIIVAHGEI
||.| | ... .... ...|..|. .. ||.....|                         |||||.| ...||.  .  |...   ..|.|..|.|| .
rEidfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggv

MWAFRVRLERLSQLRFHQLqssddprdQIHNTTILHYS
..|.. .|  |.  ....|        .. |...... 
irallayllglpleellrl........nlpngsvtvle
0053607 Phosphoglycerate mutase-like 258-445 1.2e-34 111.9 In-house 2-165 (191) alignment 
Range on Protein: 258-445
Range on HMM: 2-165/191.0
YELVLVRHGQSEGNEAQARSKrgdlsayteefkkkhssVYRLTDKGVLQAKIAGKWVRENiSEVFDRYYTSEYVRAMETASLLglpDADWLTEIQLRERD
..|.|||||..| | .                       . ||..|. ||. .... .|     ||. |.| ..||..|| ..   . .. .. .|||.|
trlyLvRHGetewnaegrlqg.................dvpLtelGreqaralaellael.glkfdavysSpllRarqTaeii...glpvevdprlrEid

KGKMDNISWTDKKDHFGNEMMMRKRDSFFWCPPGGESIANICQRVEHTFITLRRecsNKRVIIVAHGEIMWAFRVRLERLSQLRFHQL
 | ........ ......|.... ||.....||||||.| ...||.... .|..   ...|..|||| ...|.  .|  |.  ....|
fgdwegltleelaekypeelaawlrdpldyrppggEsladvaaRvlpaleella...ggnvlvVaHggvirallayllglpleellrl
subfamily_PGAM_pd Subfamily PGAM 258-394 5.9e-11 34.1 In-house 1-125 (248) alignment 
Range on Protein: 258-394
Range on HMM: 1-125/248.0
YELVLVRHGQSEGNEAQArskrgdLSAYTEEfkkkhssvyRLTDKGVLQAKIAGKWVRENISEVfDRYYTSEYVRAMETASL-LGLPDADWL---TEIQL
..|||.|||.|| |. .       .....           .|..||. .|| ||| ....  |. |  |||.  ||..|... |   |  ..   .. .|
iklvllRhGeselnkenk......fcgwvDa.........kLsekGkeeAkkagkalkqanlef.divytSvlkRaqqTlevileeldqekiPvektwrL

RERDKGKMDNISWTDKKDHFGNEMMMRKRDSFFWCPPGGES
.||  |..  .  ..  ...|.| ..  | |.   ||  | 
nErhyGaltglnkaevakkyGeekvkiwRRsydvkPPpvee
0039931 Phosphoglycerate mutase-like 259-463 4.7e-37 119.8 In-house 1-173 (219) alignment 
Range on Protein: 259-463
Range on HMM: 1-173/219.0
ELVLVRHGQSEGNEaqarskrgdlsayteefKKKHSSVYRLTDKGVLQAKIAGKWVRENiSEVFDRYYTSEYVRAMETASLLglpDADWLTEIQLRERDK
.|.|||||..| |                  .... . . ||..|. ||. .|.. ...    ||. |.| ..||..|| ..   . .. .. .|||.| 
rlyLvRHGetewnv.................egrlqgdspLterGreqaralgerlkdl.glpfdavysSpllRaiqTaeii...glpveidprLrEidf

GKMDNISWTDKKDHFGNEMMMRKRDSFFWCPPGGESIANICQRVEHTFITLRRecsNKRVIIVAHGEIMWAFRVRLERLSQLRFHQLqssddprdQIHNT
| ........ ..... |. .. ||.... ||||||.| ...||.  . .|..   ...|..|.|| ...|.  .|  ||   .. |        .. |.
gdlegltleeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleella...genvlvVsHggvirallayllglsleeilrl........nlpng

TILHY
.....
svtvl
0035570 Phosphoglycerate mutase-like 259-464 1.8e-36 118.0 In-house 1-174 (219) alignment 
Range on Protein: 259-464
Range on HMM: 1-174/219.0
ELVLVRHGQSEGNEaqarskrgdlsayteefKKKHSSVYRLTDKGVLQAKIAGKWVRENiSEVFDRYYTSEYVRAMETASLLglpDADWLTEIQLRERDK
.|.|||||..| |                  .... . . ||..|. ||. .|.. ...    ||. |.| ..||..|| ..   . .. .. .|||.| 
rlyLvRHGetewnl.................egrlqgdvpLterGreqaralgealadl.gipfdavysSpllRaiqTaeii...glpveidprLrEidf

GKMDNISWTDKKDHFGNEMMMRKRDSFFWCPPGGESIANICQRVEHTFITLrreCSNKRVIIVAHGEIMWAFRVRLERLSQLRFHQLQssddprdqIHNT
| ... .... ..... |. .. ||.... ||||||.| ...||.  . .|    ....|..|.|| ...|.  .|  |.   ...|.        ..|.
gdlegltldeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleel...edgenvlvVsHggvirallayllglpleeilrln........lpng

TILHYS
......
svtvle
0048955 Phosphoglycerate mutase-like 259-466 2e-35 115.2 In-house 2-216 (240) alignment 
Range on Protein: 259-466
Range on HMM: 2-216/240.0
ELVLVRHGQSEGNEAQARSKrgdlsayteefkkkhSSVYRLTDKGVLQAKIAGKWVRENiSEVFDRYYTSEYVRAMETAS----LLGLPDADWLTEIQLR
.|.|||||.|| | .                     .   ||..|. ||. .|.. ...    ||. |.| . ||..||      ||||  .. .. .||
rlyLvRHGesewnaegrlqg...............wtDvpLtelGreqaralgerLadl.gikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlr

ERDKGKMDNISWTDKKDHFGNEMMMRKRDSFFWCP-------------------------PGGESIANICQRVEHTFITLRREC--SNKRVIIVAHGEIM
||| | ... .... ...|..|. .. ||.....|                         |||||.| ...||.  . .|....  ..|.|..|.|| ..
ErdfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvi

WAFRVRLERLSQLRFHQLqssddprdQIHNTTILHYSRI
.|.. .| .|.  ....|        .| |. ...... 
rallayllglpleeilrl........nipngsvtvleld
0050036 Phosphoglycerate mutase-like 259-444 2.2e-29 94.3 In-house 2-154 (171) alignment 
Range on Protein: 259-444
Range on HMM: 2-154/171.0
ELVLVRHGQSEGNEAQARSKRGDLSayteefkkkhssvyrLTDKGVLQAKIAGKWVreniseVFDRYYTSEYVRAMETASLLGlpdADWLTEIQLRERDK
.|.|||||..| | ..    . |..               ||..|. ||. .|..        ||..|.| ..||..|| |..    .. .. .||||| 
rlyLvRHGetewnlegrfqgwtdvp...............Ltelgraqaralgell......pfdavysSpllRArqTaelil...lpvivdprLrErdf

GKMDNISWTDKKDHFGNemmmRKRDSFFWCPPGGESIANICQRVEHTFITLRrecsnKRVIIVAHGEIMWAFRVRLERLSQLRFHQ
| ...... . ......    . .| ....||||||.|  ..|| ...  |.     ..|..|||| ...|.  .|  ||   ...
Gawegltldeiaakype....wlldlldlappggEsladvlaRvlpaleell.....gnvlvvaHggvirallalllglsleeilr
His_Phos_1 Histidine phosphatase superfamily (branch 1) 260-430 3.8e-32 104.4 Pfam-A 2-158 (158) alignment 
Range on Protein: 260-430
Range on HMM: 2-158/158.0
LVLVRHGQSEGNEAQARSKRGDlsayteefkkkhssVyRLTDKGVLQAKIAGKWVREnISEVFDRYYTSEYVRAMETASLLGL-PDADWLTEIQLRERDK
|.|||||.|| |...  ... |              |  ||.||  ||. .||. ..  .. .|..|||.. ||..|| .|    | .  .| .||||| 
lylvRHGesewnkegrlqgwsd..............v.pLtekGreqarelgkkLkr.adlpidavytSplkRaiqTaeilleeldipiikeprLrerdf

GKMDNISWTDKKDHFGNEMMMRKRDSFFWCPPGGESIANICQRVEHTFITLRR-ECSNKRVIIVAHGEIMWAF
|.... .... |..|..|. ..|||.... ||.||| | ...||.... .| . . ....|.||.|| .. |.
geweglpkeevkeefpeeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 260-430 3.8e-32 104.4 In-house 2-158 (158) alignment 
Range on Protein: 260-430
Range on HMM: 2-158/158.0
LVLVRHGQSEGNEAQARSKRGDlsayteefkkkhssVyRLTDKGVLQAKIAGKWVREnISEVFDRYYTSEYVRAMETASLLGL-PDADWLTEIQLRERDK
|.|||||.|| |...  ... |              |  ||.||  ||. .||. ..  .. .|..|||.. ||..|| .|    | .  .| .||||| 
lylvRHGesewnkegrlqgwsd..............v.pLtekGreqarelgkkLkr.adlpidavytSplkRaiqTaeilleeldipiikeprLrerdf

GKMDNISWTDKKDHFGNEMMMRKRDSFFWCPPGGESIANICQRVEHTFITLRR-ECSNKRVIIVAHGEIMWAF
|.... .... |..|..|. ..|||.... ||.||| | ...||.... .| . . ....|.||.|| .. |.
geweglpkeevkeefpeeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral