Gene tipA in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP099_AA protein Get Run
DdisP099_AA_396-753 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
DEP Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) 38-82 1.1e-06 14.9 Pfam-A 21-71 (74) alignment 
Range on Protein: 38-82
Range on HMM: 21-71/74.0
DEIIDWISRIL---NISRAKAIEYGQLMWDRGVLEIIGLP---FGDNSQLF
 |..||.  ..    ..|..|.|.|||. | |..| ..     | |..| |
seavdWLldnfedkiedreeAvelgqlLldqgliehvekrhsgFrdskqaf
PP2Cc_SM00332 397-704 6.2e-23 74.5 In-house 14-272 (274) alignment 
Range on Protein: 397-704
Range on HMM: 14-272/274.0
YPHLPNHPKREGDPICDHFCVQIQASRIIAAVADGcnwgsrpaEAATRASISFVDFMSKALSSEIQTVQD-----AGNHILSAFNYAHNRIVEGKSDIWE
. . ....|.  | .. .........  . .|.||        .. ....  . . . .||..|.....|       ... .||. ....|.| ..  ..
kssmqgwrksmeDahvvvvdlveeedwlffgvfDG........hgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskel

---AGTTTLLGGVLVELQqseaskpepssqlgrsgvnkpviganfanltgsgivsnglsasvnnagsivkdinappskwgFICASVGDCKAFHYSASSkk
      .|..  .|.. .                                                              ...|.|||..|.......  
enalsGstavvallkked..............................................................lyvanvGDSravlcrngk..

FTDITKNNRGNVDDPKDPGGRLGP-----YVANGQPDLRNLCLHFLP---------------------CNENDIIVLISDGVHDNLDPQTVGWTPRDLQL
............ | ..   . |.     .| .|.   |... |||                      ..|.....|.|||..|.|..|.| .. |.|  
avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrklla

NYenwSDMEPDKALEAKTKYTQEFlkkklrthDQEQDPITAK
.    ....|..| |  ......         .. .| ||. 
kg...ktndpqeaaelldeeairr........ggseDniTvv
subfamily_tipA_pd Subfamily tipA 402-716 1.4e-168 549.1 In-house 1-296 (296) alignment 
Range on Protein: 402-716
Range on HMM: 1-296/296.0
NHPKREGDPICDHFCVQIQASRIIAAVADGCNWGSRPAEAATRASISFVDFMSKAlSSEIQTVQDAGNHILSAFNYAHNRIVEGKSDIWEAGTTTLLGGV
|..|||||||.|.|.||....|.|.|.|||||||.|||||||.||..||||.|.. ||||.||.|||...||||..||..||||||||||||||||||||
nttkregdpiadrftvqvyknrlivaladGcnWGkrPaeaatnasaafvdflsek.sseintvkdaGkfllsafeaahkkiveGksdiweaGtttllGGv

LVELQQSEaSKPEPSSQLGRSGVNKPVIGANFANLTGSGivsNGlsasvNNAGSivkDINAPPSKWGFICASVGDCKAFHYSASSKKFTDITKNNRGNVD
|.||.||| ||||.|||...|.|||.|||||||||||||   ||     |||||   |||...|||||.||||||||||..|..||..|||||.||.|||
lleleqse.skpesssqkrksevnkeviganfanltgsg...ng.....nnags...dinkssskWgfvcasvGdckafllskkskevtditkgnrsnvd

DPKDPGGRLGPYVANGQPDLRNLCLHFLPCNENDIIVLISDGVHDNLDPQTVGWTPRDLQLNYENWSDMEPDKALEAKTKYTQEFLKKklrthdQEQDPI
|.|||||||||||..|.||||||.|.||.|.|.|||.|.||||||||||.|.|.||||||||||.|||.|.|||||||||||.|.|||      .|.|.|
dakdpGGrlGPyveqGkPdlrnlklffllceeediillvsdGvhdnldPktlgktprdlqlnyekwsdvefdkaleaktkytaellkk......leadsi

TAKFITEKLVEHCVE
.||.|.|||||||||
dakeiseklvehcve
subfamily_CG9801_pd Subfamily CG9801 406-688 1.4e-134 437.3 In-house 1-251 (252) alignment 
Range on Protein: 406-688
Range on HMM: 1-251/252.0
REGDPICDHFCVQIQASRIIAAVADGCNWGSRPAEAATRASISFVDFMSKALSSEIQTVQDAGNHILSAFNYAHNRIVEGKSDIWEAGTTTLLGGVLVEL
||||||.|.|.|.....|.|.|.|||||||.||||||..||..|.|..|||||.||.|||..|...|.|...||..||||||..|||||||||||||.||
reGdPiaDkftvvvrknrlilalaDGcnWGerpaeaarsasaafidylskalskeittvqevgksllaaleeahksivegkselweaGtttLlggvllel

QQsEASKPEPSSQLGRSGVNkpviganfanltgsgivsnglsasvN--NagsivkdiNAPPSKWGFICASVGDCKAFHYSASSKKFTDITKNNRGNVDDP
.. ||.|||.|||||.|.|.                            .        ||..|||||.||||||||||.|||..|..|||||.||.|..|.
ek.eaekpesssqlgksevg.........................lsas........nassskwgfvcasvGDckaflysakkkevtditkgnrsnlsDa

KDPGGRLGPYVANGQPDLRNLCLHFLPCNENDIIVLISDGVHDNLDPQTVGWTPRDLQLNYENWSDMEPDKALEAKTKYTQEFLK
.|.||||||||..|.||||||.|.|....|.|||.|.||||||||||||.|.|||||.||.|.|||.|.|||||||||.|.|.|.
rDagGrLGPyveqgkPdLrnLklfftlveeeDiillvsDGvhDnlDPqtlgktprdlnlnaekwsdleqdkaleaktkftkelle
subfamily_CG9081_pd Subfamily CG9081 408-653 1.8e-36 116.2 In-house 2-193 (195) alignment 
Range on Protein: 408-653
Range on HMM: 2-193/195.0
GDPICDHFCVQIQASRIIAAVADGCNWGSRPAEAATRASISFVDFMSKALSS--EIQTVQDAGNHILSAFNYAHNRIVEGksdiwEAGTTTLLGGVLVEL
|.|. | | | ..    | |.||| ||| ..  ||  |  . |..... | .     . .|  ...| ... |...|.|      .. .|||  .|..||
gePvadvfavvarennaimaladGvnWGkkarlaarsavagavaylndklfklsakpnsrdlfklllesleeaqksilen.....sgtlttlsiavvcel

QQSEASkpepssqlgrsgvnkpviganfanltgsgivsnglsasvnnagsivkdinapPSKWGFICASVGDCKAFHYSASSKKFTDITKNNRGNV--DDP
. ..                                                       |.||.. .||||  .| || . |. ...| .   .    |.
kankki....................................................ssqWglfvvsvGdspvfvyspdnksvrevtvashskdgirdv

KDPGGRLGPYVANgQPDLRNLCLHFLPCNENDIIVLISDGVHDNLDPQTV
...|| ||| . . .||| || | .|| .| ||..|.|||| ||.||. |
rlsGGalGpaiGt.dpdlenlslsylpvaeGdivfltsdGvsdnfdPvvv
subfamily_Sponge-PPM-1_pd Subfamily Sponge-PPM-1 408-653 1.4e-34 109.4 In-house 2-194 (199) alignment 
Range on Protein: 408-653
Range on HMM: 2-194/199.0
GDPICDHFCVQIQASRIIAAVADGCNWGSRPAEAATRASISFVDFMSKAL---SSEIQTVQDAGNHILSAFNYAHNRIVEGksdiwEAGTTTLLGGVLVE
|.|. | | | ..    | |.||| ||| .|  ||  |  . . ..|. |   |.. .. ..  ...| ... ||..|.|      |  .|||  .|. |
GepvadvfavvarennaimaiadGvnwGkkprlaarcavqgaiayisdnlfklsakptnsrtltklllesldeahksileh.....eGtlttlsiavvce

LQQSeaskpepssqlgrsgvnkpviganfanltgsgivsnglsasvnnagsivkdiNAPPSKWGFICASVGDCKAFHYSASSKKFTDITKNNRGN--VDD
|.                                                      ... |.||.. |||||   | || . |. ...| .   .  . .
lkpn....................................................srsssrwglfvasvGdspvfvyspdtksvheatvachdkdGirt

PKDPGGRLGPYVANgQPDLRNLCLHFLPCNENDIIVLISDGVHDNLDPQTV
... || ||| . . .||| || | .|| .| ||..|..||..||..|. .
arlsGGalGpaiGt.dpdlenlslsylpvaeGdivllttdGisdnfapvvl
0034914 PP2C-like 409-753 5e-12 38.5 In-house 33-289 (295) alignment 
Range on Protein: 409-753
Range on HMM: 33-289/295.0
DPICDHFCVQI-----QASRIIAAVADGCNWGSRPAEAATRASISFVDFMSKALSSEIQTVQDAGNHILSAFNYAHNRIVEGKSD---IWEAGTTTLlGG
..  | ..| .     . . ....|.|| .  .    |. ..   ..... | | .   .  |  ... .||  |.....|   .    .  ||| .   
ksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallrpelagsGtTav.va

VLVELqqseaskpepssqlgrsgvnkpviganfanltgsgivsnglsasvnnagsivkdinappskwGFICASVGDCKAFHYsaSSKKFTDITKNNRGNV
....                                                                ...| |||..|. .  ...... .|.  . . 
lirgn..............................................................klyvanvGDSravll..rngelvqltvdhkpvn

DDPKDPGGRLGPYVANGQPD-------------LR----------------NLCLHFLPCNENDIIVLISDGVHDNLDPQTVGWTPRDLQLNYENwsdme
 . .    ..|..| .|.               |                  .. . |  ...|...| |||..|.|.....    |.|  .. .     
elererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld.....

pdkaleaktkytqeflkkklrthdqeqdpitAKFITEKLVEHCVEttkssrefmvnfpnkplpdnlkeyKGKMDHVTCVAFK
                               .. . |.||.....                        .|..| .|.|  .
...............................leeaaeeLvdlAla........................rgsrDNiTvvvvr
0049733 PP2C-like 413-677 7.3e-12 38.4 In-house 20-219 (235) alignment 
Range on Protein: 413-677
Range on HMM: 20-219/235.0
DHFCVqiqaSRIIAAVADGCNWGSRPAEAATRASISFVDFMSKalsseiQTVQDAGNHILSAFNYAHNRIVEGKSDI--WEAGTTTLLGGVLVELQqsea
| ..|    .....||||| . .   . |. ..   ..... .      ..  |  . . .|| .|.....|   .   .  . ||..  .|.. .    
Davlv....glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspelagmgtTavvalldggk....

skpepssqlgrsgvnkpviganfanltgsgivsnglsasvnnagsivkdinappskwgFICASVGDCKAFHYSasSKKFTDITKNNRGNVDDPKDPGGRL
                                                          ...|.|||. |....  ..|.. .|.... . ....    ..
..........................................................lyvanvGDsrayllr..dgklvqltedhspvnelerqriita

GPYV----------------ANgqpdlrnLCLHFLPCNENDIIVLISDGVHDNLDPQTVGWTPRDlqLNYENWSDMEPDKALE
|..|                 .         ...|. ...|...| |||..|.|.....  . |.  |..|.. ..  . ||.
ggavrvpgrlaltralGdlllk.......pdvtvlelepgdflllasDGlwdvlsdeeivdllrs..ldleeaaerlvelala
PP2C_SIG_SM00331 416-652 5.7e-07 22.3 In-house 23-168 (217) alignment 
Range on Protein: 416-652
Range on HMM: 23-168/217.0
CVQIQASRIIAAVADGCNWGSRPAEAATRASISFVDFMSKAlsseiQTVQDAGNHILSAFNYAhnrivegksdiweagtttllggvlvelqqseaskpep
 |.... |....||||.  | . |.|. ..   .  ..|.      .....| ... .|..                                       
vvklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.....eelsqalkrlnraiyee.....................................

ssqlgrsgvnkpviganfanltgsgivsnglsASVNNAGSIVKDINAPPSKWGFICASVGDCKAFHYSaSSKKFTDITKnnrgnvddpkdpggrLGPYVA
                                . ... . ..  .  ..|.  .  |..||.  . .  ..| .....                  ....
................................keekgmfaTlllalydfssgklsyanaGdsrpyllr.dgklveilkd...............vegapl

NGQPDLRnLCLHFLPCNENDIIVLISDGVHDNLDPQT
  .|... .  . |  .. |...| .||....  ...
Glepevs.vdirelelekgdllllytDGltearsekg