Gene DDB_G0270176 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily LRR-PPM
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP102_AA protein Get Run
DdisP102_AA_1095-1359 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
LRR_8 Leucine rich repeat 268-322 6.1e-10 28.4 Pfam-A 4-60 (61) alignment 
Range on Protein: 268-322
Range on HMM: 4-60/61.0
QRLLLGRNKLTEIPERIGE-LQRLTSIDLSYNRLTHVP-VSISTLQDLISLSLTGNK
..| | .|.|..||... . |..|...|||.|.|....  ... |. | .|.| ||.
keLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNr
LRR_4 Leucine Rich repeats (2 copies) 268-303 1.9e-08 23.7 Pfam-A 4-39 (44) alignment 
Range on Protein: 268-303
Range on HMM: 4-39/44.0
QRLLLGRNKLTEIPERIGELQRLTSIDLSYNRLTHV
. | | .|.....|. .. |. |....||.|... .
evLdLsnNnIkdlppelanLpnLktLnLsnNpisdl
LRR_4 Leucine Rich repeats (2 copies) 289-323 3.6e-07 19.6 Pfam-A 2-36 (44) alignment 
Range on Protein: 289-323
Range on HMM: 2-36/44.0
RLTSIDLSYNRLTHVPVSISTLQDLISLSLTGNKF
 |...|||.|... .| ... |..| .|.|..|..
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpi
LRR_4 Leucine Rich repeats (2 copies) 579-618 4.3e-07 19.4 Pfam-A 2-41 (44) alignment 
Range on Protein: 579-618
Range on HMM: 2-41/44.0
SLTYLDISNNHLTELPIELGQLVYLTTFIANDNYIKCIPP
.|..||.||| ...|| ||..|  |.|   . | |  ...
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa
LRR_4 Leucine Rich repeats (2 copies) 630-669 2.6e-10 29.6 Pfam-A 2-41 (44) alignment 
Range on Protein: 630-669
Range on HMM: 2-41/44.0
SIRTIDLSNNEIQEIPDDFSYLLYLENLNLSNNQISTIPN
. ...||||| |...| ... |  |..||||||.|| ...
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa
LRR_8 Leucine rich repeat 630-674 5.5e-10 28.5 Pfam-A 2-47 (61) alignment 
Range on Protein: 630-674
Range on HMM: 2-47/61.0
SIRTIDLSNNEIQEIPDD-FSYLLYLENLNLSNNQISTIPNSLFQG
.....|||||....||.. |..|  |. |.||.| ...|.  .|.|
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkg
LRR_1 Leucine Rich Repeat 654-674 4.2e-06 16.7 Pfam-A 2-21 (22) alignment 
Range on Protein: 654-674
Range on HMM: 2-21/22.0
LENLNLSNNQISTIPNSlFQG
|| |.||.|.....|.| ...
LeeLdLsgNnltslpps.lsn
LRR_8 Leucine rich repeat 683-743 4.5e-09 25.6 Pfam-A 2-61 (61) alignment 
Range on Protein: 683-743
Range on HMM: 2-61/61.0
SLKSLKLRGNKLDELPSNFFLTCaSTLKYLDLSFNNLSILPNNGLKYLDQLSTCLLFNNSL
.||.| |..|.|...| ..|  . | ||.|||| |||. .. . .| | .|.   | .|.|
nLkeLdLsnNrlkviptgsFkgl.snLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
subfamily_pats1_pd Subfamily pats1 740-805 4e-06 17.5 In-house 239-304 (691) alignment 
Range on Protein: 740-805
Range on HMM: 239-304/691.0
NNSLKTIPNEFFEQIDDDDDNNKNNNNNNNNNNNNNNNNNNNNNNDIKPNLTNLNLSGNKLTEISK
|. .. | ... ..  ....|| ||||||||.|||||||||||||.   |  | | |..| ...  
nkefqqihqqmqqnqlnsssnnnnnnnnnnnsnnnnnnnnnnnnnnnnnnnnnnnnsnskinkrdn
LRR_4 Leucine Rich repeats (2 copies) 788-824 7.7e-09 24.9 Pfam-A 1-37 (44) alignment 
Range on Protein: 788-824
Range on HMM: 1-37/44.0
PNLTNLNLSGNKLTEISKDIWKCKSLVNLSLGYNDIK
.||. |.||.|...... .. ....| .|.| .| | 
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpis
LRR_8 Leucine rich repeat 788-846 4.1e-08 22.5 Pfam-A 1-60 (61) alignment 
Range on Protein: 788-846
Range on HMM: 1-60/61.0
PNLTNLNLSGNKLTEISKDIWK-CKSLVNLSLGYNDIKLIefPSNL--VLYSLEELYLNGNK
|||..|.||.|.|..|.... | ...|  |.|..| .| |  ....   |.||.||.| ||.
pnLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksi..speafkgLpsLreLnLsgNr
LRR_8 Leucine rich repeat 875-914 4.3e-09 25.6 Pfam-A 3-42 (61) alignment 
Range on Protein: 875-914
Range on HMM: 3-42/61.0
LRELCLGSCELKEIPTFCKENLKSLEKLDLSNNQLICLPE
|.|| | ...||.||| . ..|..|..||||.| |. ...
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksisp
LRR_4 Leucine Rich repeats (2 copies) 875-909 4.4e-08 22.5 Pfam-A 3-36 (44) alignment 
Range on Protein: 875-909
Range on HMM: 3-36/44.0
LRELCLGSCELKEIPT-FckENLKSLEKLDLSNNQL
|..| | .. .|..|  .   ||..|. |.||||..
LevLdLsnNnIkdlppel..anLpnLktLnLsnNpi
LRR_8 Leucine rich repeat 914-955 2.6e-08 23.2 Pfam-A 19-60 (61) alignment 
Range on Protein: 914-955
Range on HMM: 19-60/61.0
EWIGEFEHLLVLYLSRNQISTLPYKEFKNLKNLIILDLSMNN
.. .  ..| ||.||.| ..... . ||.|..|  |.|| |.
gsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNr
LRR_4 Leucine Rich repeats (2 copies) 922-957 4.5e-07 19.3 Pfam-A 3-36 (44) alignment 
Range on Protein: 922-957
Range on HMM: 3-36/44.0
LLVLYLSRNQISTLPYkEFKNLKNLIILDLSmNNQL
| ||.||.|.|. ||  |..||.||  |.|| ||..
LevLdLsnNnIkdlpp.elanLpnLktLnLs.nNpi
0034914 PP2C-like 1096-1359 4.2e-68 222.2 In-house 15-290 (295) alignment 
Range on Protein: 1096-1359
Range on HMM: 15-290/295.0
ITKSKRFEMSFSDMIGRRPSMEDSFSIFGSFNDGSGdDYDLISLFDGHAGSRAATYSSEWFPKIMKSL------MNIYPSLPPLQWLKQAYNEISLQFKM
..   ..  ......|||.|.||..... ... . . |. |. .|||| |..|| . ||........|      .. ...  ....|..|. ..  ..  
sslllllrvgvasdqGrrksneDavlvvlnllslle.dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeelle

YINNeRPDLKYCGATAASLLITRDFYCVSNIGDTRIVLCqKDGTAKRLSFDHKPSDPSETKRISRLGGFVVSnqhtSRVNGTLAVSRSIGDIYME-----
.. . ||.| ..|.||  .||..... | |.||.|.||. ..|....|..||||....| .|| ..||.|.     .||||.|||.|..|| ..      
lall.rpelagsGtTavvalirgnklyvanvGDSravll.rngelvqltvdhkpvnelererilsaggavsh....grvngvlavtRalGdfdlklllsl

----PFVVPDPYLSQTNRNFEMDKYLIVACDGIWDEISDQQACNIVLN----SNSTDEACTKLKDYAYFSGSDDNITVIVIKL
    |.|.. |.........| |..|..|.||.|| .|......|| .    ... .||...| |.|.  || |||||.|..|
llleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 1097-1359 7.7e-137 447.6 In-house 1-253 (255) alignment 
Range on Protein: 1097-1359
Range on HMM: 1-253/255.0
TKSKRFEMSFSDMIGRRPSMEDSFSIFGSFNDGSGDDYdlISLFDGHAGSRAATYSSEWFPKIMKSLMNIYPSlPPLQWLKQAYNEISLQFkmyinNERP
..|.||...|||||||||.|||...|.|||.|.|..||  ..|||||.|..||...||...||...|...... .|...||.||.|||.|.     .|||
sdssrfkvgfsdmiGrrptmedelviyGsfrdksdedy..yalfdGhgGraaakfaseelykilaelldlnna.nPvkslkkaykeistqi.....serp

dlKYCGATAASLLITRDFYCVSNIGDTRIVLCQKDGTAKRLSFDHKPSDPSETKRISRLGGFVVSNQHTSRVNGTLAVSRSIGDIYMEPFVVPDPYLSQT
  |..|.||||.||..|.....|.||.|.|||||||||||||.|||||..||.||||.|||.|||...||||||||||||..||...||||||||.|||.
..kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqs

NRNFEMDKYLIVACDGIWDEISDQQACNIVLNSNSTDEACTKLKDYAYFSGSDDNITVIVIKL
......||.||.|||||||.|||..|..||........|..||.|.||.|||.|||.||||||
leiskkdkflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisvivikl
subfamily_PPM1G2_pd Subfamily PPM1G2 1097-1358 4e-39 127.3 In-house 14-285 (287) alignment 
Range on Protein: 1097-1358
Range on HMM: 14-285/287.0
TKSKRFEMSFSDMIGRRPSMEDSFSIFGSFND-GSGDDYDLISLFDGHAGSRAATYSSEWFPKIMKSlMNIYPSLPPLQWLKQAYneISLQFKMYINNER
.. . .... | | | | .|||.  .   . .    ..  |...|||| |...| |... . |....  . . .    | ||.|.  ...  ... ... 
canaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.kksfkegaleqilkdaf..letDeellkdekl

PDlKYCGATAASLLITRDFYCVSNIGDTRIVLCQKDGtAKRLSFDHKPSDPSETKRISRLGGFVVSNqhtsRVNGTLAVSRSIGDIYM---------EPF
 | . .|.|| . ||. .   |.|.|| | ||..|   .| |||||||.. ||.|||   ||||  |    ||||.||.||..||            |  
kd.esaGstavvvlikeeklyvanaGDsravlsskgn.vkalsfDhkPqeesekkriiaagGfveln....rvngnLalsralgDfefkknvkkkpeeqi

VVPDPYLSQTNRNfEMDKYLIVACDGIWDEISDQQACNIVL----NSNSTDEACTKLKDYAYFSGSD------DNITVIVIK
|   | .  .... | | .|..||||||| ..... ...|     .  . || ...| | .    |.      ||.||... 
vtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivv
subfamily_PPM1G_pd Subfamily PPM1G 1098-1163 6.9e-07 21.6 In-house 15-76 (473) alignment 
Range on Protein: 1098-1163
Range on HMM: 15-76/473.0
KSKRFEMSFSDMIGRRPSMEDSFSIFGSFNdgsgDDYDLISLFDGHAGSRAATYSSEWFPKIMKSL
 ........| | | | |.||.      ..    .|  | . .||| |.  |.| .. .|...|  
sneelsygasamqGwrvsqEDahncitdld....edtslfavyDGHGGkevakyvakklpdllkaq
PP2Cc_SM00332 1100-1357 8.7e-56 182.3 In-house 8-274 (274) alignment 
Range on Protein: 1100-1357
Range on HMM: 8-274/274.0
KRFEMSFSDMIGRRPSMEDSFSIFGSFNdgSGDDYDLISLFDGHAGSRAATYSSEWFPKIMKSLMNIYPS---LPPLQWLKQAYNEISLQFKMYINNERP
...  ..|.| |.| |||| . .  ...  . .|  ....||||.||..| . |. .|...|. ..   .     . ..||.|....  ..    .....
lglsygkssmqgwrksmeDahvvvvdlv..eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskel

DLKYCGATAASLLITRDFYCVSNIGDTRIVLCQKDGtAKRLSFDHKPSDPSETKRISRLGGFVVSNqhtsRVNGTLAVSRSIGDIYME-------PFVVP
.   .|.|| . |....   |.|.|| |.|||...  |..|| ||||.|..|.|||.. ||.|  .    ||||.|||||..|| ..        |....
enalsGstavvallkkedlyvanvGDSravlcrngk.avqlsvdhkpedederkRikkaggvvekg....rvngglavsrafGdhflkknkklkepyita

DPYLSQTNRnFEMDKYLIVACDGIWDEISDQQACNIVLNS------NSTDEACTKLKDYAYFS-GSDDNITVIVI
.|  ....   . |. ||.|.||.|| .|.|....|| .       |. .||...| ..|. . || |||||.|.
epdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 1101-1358 1.2e-57 188.5 In-house 11-279 (282) alignment 
Range on Protein: 1101-1358
Range on HMM: 11-279/282.0
RFEMSFSDMIGRRPSMEDSFSIFGSFNdgSGDDYDLISLFDGHAGSRAATYSSEWFPKIMKS---LMNIYPSLPPLQWLKQAYNEISLQFKMYINNERPD
 . .. | | |.| .|||....  |..  .  |  . ..|||||||..|.|... ... . .   | .   .  . . .|.| ..  |..   |...  |
glrygvssmqgwrvemEDahtvvaslg..alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstd

LK---YCGATAASLLITRDFYCVSNIGDTRIVLCQKdGTAKRLSFDHKPSDPSETKRISRLGGFVVsnqhTSRVNGTLAVSRSIGDIYMEP---------
||    .|.|| ..|.. . . . |.||.|.|||.. |.|..|. |||||.|.|.|||.  ||.||    .|||||.|||||..||  ..          
lktadksGsTavtvlvsekhliianlGDsRavlcrn.gkaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGaLAvsRalGDyeykeeeekkaeeq

FVVPDPYLSQTNRNFEMDkYLIVACDGIWDEISDQQACNIVLNS----NSTDEACTKLKDYAYFSGSDDNITVIVIK
 |...|.   ..|. | | .|..||||||| .||......| ..    .   | ...| |.|.  || ||..|.|. 
lvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvl
0049733 PP2C-like 1102-1359 4.1e-50 163.2 In-house 3-233 (235) alignment 
Range on Protein: 1102-1359
Range on HMM: 3-233/235.0
FEMSFSDMIGR-RPSMEDSFSIfgsfndgsgdDYDLISLFDGHAGSRAATYSSEWFPKIMKSLMNIYPSLPPLQWLKQAYNEISLQFKMYINNERpDLKY
...... .||| |. .||.. .          .. |. ..||| |..|. . ||........|.  ...| ....|..|. ..  ..  .  ... .| .
lsvgaasdigrvrkvneDavlv..........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalasp.elag

CGATAASLLITRDFYCVSNIGDTRIVLCQkDGTAKRLSFDHKPSDPSETKRISRLGGFVvsnqhtsRVNGTLAVSRSIGDIYMEpfvvpdpyLSQTNRNF
.|.||. .|.. ....| |.||.|..|.. ||.. .|..||.|... | .|| ..||.|       ||.| ||..|..|| ...           |  . 
mgtTavvalldggklyvanvGDsrayllr.dgklvqltedhspvnelerqriitaggav.......rvpgrlaltralGdlllk........pdvtvlel

EMDKYLIVACDGIWDEISDQQACNIVLNsNSTDEACTKLKDYAYFSGSDDNITVIVIKL
| . .|..|.||.|| .||....... . .. .||. .| ..|.  |. |||||.|..|
epgdflllasDGlwdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 1102-1357 5.9e-47 153.0 In-house 4-260 (265) alignment 
Range on Protein: 1102-1357
Range on HMM: 4-260/265.0
FEMSFSDMIGRRPSMEDSFSIFGSFNDGSG----DDYDLISLFDGHAGSRAATYSSEWFPKIMKSLMNIYPSlpPLQWLKQAYNEISLQFKMyiNNERPD
.|.|   . ..|  ||| . .. ..|   .    ...   . ||||.|. ||.|...  .. . .  ..  .  |.. ||.|....  .|      ||  
yevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklked..paealkeafkltDerflq..kaerek

LKyCGATAASLLITRDFYCVSNIGDTRIVLCQKdGTAKRLSFDHKPSDPSETKRISRLGGFVVSNqHTSRVNGTLAVSRSIGDIYMEPFVVPDPYLSQTN
|| .|.|| . ||..|   |. .|| . .|..| |.| .|   |||... | |||  .||.||    . ||||.|.|||.|||   .|.|. .. .....
lk.sGstavvvliekdqlyvaWlGDsqallvrk.geavqlmkpHkPeredEkkRieeagGlvvvi.gawRvnGvLsvsRaiGDvklkpyvsgeadvaeve

RNfEMDKYLIVACDGIWDEISDQQACNIVLNS---N--STDEACTKLKDYAYFSGSDDNITVIVI
 . . ..|||.||||.|| . .......| ..   .  ...|.  .| . |.  ||.|||||.|.
ld.gseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvv
PP2C Protein phosphatase 2C 1104-1352 9.6e-58 188.7 Pfam-A 3-255 (255) alignment 
Range on Protein: 1104-1352
Range on HMM: 3-255/255.0
MSFSDMIGRRPSMEDSFSIFGSFND-GSGDDYDLISLFDGHAGSRAATYSSEWFPKIMKSLMNIYPSLPPLQWLKQAYNEiSLQFKMYINNE-RpDLKYC
 ..|.. |.| ||||.  .  ...  .. ..  ..  ||||.|..||.| .|  ..|.|.    ...    ..|.... . ... ... ... .    ..
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfla.dtdeelksskant.epsks

GATAASLLITRDFYCVSNIGDTRIVLCQKDGTAKRLSFDHKPSDPSETKRISRLGGFVVSnqhTSRVNGTLAVSRSIGDIYMEP----FVVPDPYLSQTN
|.|| . ||. .   | |.||.|.|||.||...|.|..||||||..|..||...||.|       ||||.|||||..|| .. |    .|...|......
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn...ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvk

RNFEmDKYLIVACDGIWDEISDQQACNIVLNSNS----TDEACTKLKDYAYFSGSDDNI
.. | |..||.|.||.|| .|||.|. .| .  |     .||...| |.|. .|| |||
ltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 1104-1352 9.6e-58 188.7 In-house 3-255 (255) alignment 
Range on Protein: 1104-1352
Range on HMM: 3-255/255.0
MSFSDMIGRRPSMEDSFSIFGSFND-GSGDDYDLISLFDGHAGSRAATYSSEWFPKIMKSLMNIYPSLPPLQWLKQAYNEiSLQFKMYINNE-RpDLKYC
 ..|.. |.| ||||.  .  ...  .. ..  ..  ||||.|..||.| .|  ..|.|.    ...    ..|.... . ... ... ... .    ..
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfla.dtdeelksskant.epsks

GATAASLLITRDFYCVSNIGDTRIVLCQKDGTAKRLSFDHKPSDPSETKRISRLGGFVVSnqhTSRVNGTLAVSRSIGDIYMEP----FVVPDPYLSQTN
|.|| . ||. .   | |.||.|.|||.||...|.|..||||||..|..||...||.|       ||||.|||||..|| .. |    .|...|......
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn...ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvk

RNFEmDKYLIVACDGIWDEISDQQACNIVLNSNS----TDEACTKLKDYAYFSGSDDNI
.. | |..||.|.||.|| .|||.|. .| .  |     .||...| |.|. .|| |||
ltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 1105-1352 7.6e-57 185.7 In-house 4-259 (259) alignment 
Range on Protein: 1105-1352
Range on HMM: 4-259/259.0
SFSDMIGRRPSMEDSFSIFGSFND-GSGDDYDLISLFDGHAGSRAATYSSEWFPKIMKSLMNIYPSLPPLQWLKQAYNEISLQFKMYINNE-RpDLKYCG
..| . |.| ||||.  ..  ..  .. |.  . . ||||.|..||.| .| ...| |.    ...  . ..|. .. ....  ...  .. .   ...|
gasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseant.epstsG

ATAASLLITRDFYCVSNIGDTRIVLCQKDGTAKRLSFDHKPSDPSETKRISRLGGFVVSNqHTSRVNGTLAVSRSIGDIYMEP------FVVPDPYLSQT
.|| ..||| .   | |.||.|.|||......|.|..|||||...| .||...||.| .    .||||.|||||..|| .. |       |...|. |.|
stAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnv.gngrvngvlavsRafGdfelkpketeeqlvsaePdisst

NRNFEmDKYLIVACDGIWDEISDQQACNIVLNSNS---TDEACTKLKDYAYFSGSDDNI
... | |..||.|.||.|| .|||.|. .| .  |    .||..|| |.|. .|| |||
kidee.defliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
subfamily_PPM1L_pd Subfamily PPM1L 1105-1359 1.9e-44 144.9 In-house 8-266 (269) alignment 
Range on Protein: 1105-1359
Range on HMM: 8-266/269.0
SFSDMIGRRPSMEDSFSIFGSFNDGSGDdyDLISLFDGHAGSRAATYSSEWFPKIMKSLM-NI---YPSLPPLQWLKQAYNEISLQFKMYINNERPDLKY
.   . |||| ||| | |    ... |   .....|||| |  || .. . ..| .|. . ..        |... |   .||    .  ... .   . 
avysvlGrrprmedrfeieediknktge..sffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedi

CGATAASLLITRDFYCVSNIGDTRIVLCQKDGTAKRLSFDHKPSDPSETKRISRLGGFVVSNqHTSRVNGTLAVSRSIGDIYM--EPFVVPDPYLSQTNR
 |.||   |.. .   |.|.||.| ||..|.|.|  ||||||| .. | ||| . |||.  .  . ||.| ||.||..||  .  . .|..|| .   . 
aGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafr.GvwrvaGvlatsralGdyplkdknlviadpdiltfdl

NFEMDKYLIVACDGIWDEISDQQACNIVLNSNSTDEA-CTKLKDYAYFSGSDDNITVIVIKL
.    ..||.|.||.|| .|...|.. ...  .  .     |   ..  || |||||.|.||
ddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvkl
subfamily_ILKAP_pd Subfamily ILKAP 1105-1343 9.6e-31 100.0 In-house 8-256 (293) alignment 
Range on Protein: 1105-1343
Range on HMM: 8-256/293.0
SFSDMIGRRPSMEDSFSIFGSFNDGSGDDYDL------ISLFDGHAGSRAATYSSEWFPKIMKSLMNIyPSLPP-----LQWLKQAYNEISLQFKMYINN
 ..   | |  |.|.  |. .... .. . .|       ..|||||||||. ...| . | ... .    ..        . | .....   .|    ..
ayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsakekeikkclvdsfkktdeefLklask

ERPDLKYcGATAASLLITRDFYCVSNIGDTRIVLCQKDGTAK-----RLSFDHKPSDPSETKRISRLGGFVVSNqhtsRVNGTLAVSRSIGDI-YMEPFV
..|  |  |.||...|.  .   |.|.||.. ||..|.  ..     .|. ||.| .  | ||| . ||.|  .    ||.| | |||||||  . .  |
akPvWkd.GstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg....rvlGvlevsrsiGdgrfkrlGv

VPDPYLSQTNRNFEmDKYLIVACDGIWDEISDQQACNIVLNSNSTDEACTKLKDYA
.  | ... . .   |.....||||.|. .| ... . .|.    .|  .|.|.  
istPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeee
PPM_PTC7_SpoIIE 1105-1357 7e-27 87.7 In-house 4-227 (230) alignment 
Range on Protein: 1105-1357
Range on HMM: 4-227/230.0
SFSDMIGRRPSMEDSFSIFGSFND-GSGDDYDLISLFDGHAGSRaaTYSSEWFPKIMKSLMniYPSLP-PLQWLKQAYNEISLQFKMYinnerpdLKYCG
..| . |.| ||||.  ..  ..  . |.   ..  .||| |.   .. .. . .....|   ...|. | ..|. .. ... ... .        . .|
gasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela..faglekpeeilrrlnlalaadlede.......psssg

ATAASLLITRDF--YCVSNIGDTRIVLCQKDGTakrlsfdhkpsdpsETKRIsRLGGFV-V---SNqhtsRVNGTLAVSRSIGDIYMEP---FVVPDPYl
|||  .||. .     |.| || ...|...||.              | .||  .||.. .   ..    ||.|.||||...||... .    | . |. 
aTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpg....rvfgvlavslapGdllllytDGvveaepd.

SQTNRNFEMDKYLIVACDGIWDEISDQQACNIVLNSNSTDeactklkdyAYFSGSDDNITVIVI
..... |..|..||.|.||.||  |.|... .|... .           |.  . .| ||..|.
tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.........aaeglleDDitllvv
subfamily_PPM1K_pd Subfamily PPM1K 1106-1358 3.7e-39 127.4 In-house 8-257 (263) alignment 
Range on Protein: 1106-1358
Range on HMM: 8-257/263.0
FSDMIGRRPSMEDSFSIFGsFndgsGDDYDLISLFDGHAGSRAATYSSEWFPKIMKSLMNIYPSLPPLqwLKQAYNEISLQFKMYINNERPDLKY--CGA
.  .||.|   || ...   .     ..   ...||||||| || .  . . ||.| |..    |  .  ||.|..|.  ..| |.. . .. ..   |.
kdsliGkraenedriklke.l....dpellyvavfdGhaGsaaadfvhdklekilkrllekekdleiv..lknafeeldkklkrylefsvaeaellssGt

TAAS-LLITRDFYCVSNIGDTRIVLCQKdGTAKRLSFDHKPSDPSETKRISRLGGFVVSNQ-HTSRVNGTLAVSRSIGDIYMEPF-VVPDPYLSQTNRNF
||.  ||       ....||.| .||.. | ||.|. ||.|.   | .|| . ||.| .|     .||| ||..||.||. . .. |. .|   . . . 
tatvsllrdGtelvlaslGdsrailcrn.GkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdh

EMDKYLIVACDGIWDEISDQQACNIVLNSNSTDEACTKLKDYAYFSGSDDNITVIVIK
. | .|..  ||| . ...|. |..|   .  .||   | . |   ||.|| |..|. 
aadsflvlitdgisfvvnsqelcdlvrlchdpeeaahalteqalqygsednatavvvp
subfamily_PPM1D_pd Subfamily PPM1D 1110-1335 3.6e-28 91.6 In-house 10-270 (309) alignment 
Range on Protein: 1110-1335
Range on HMM: 10-270/309.0
IGRRPSMEDSFSIFGSF-NDGSGDDYDLISLFDGHAGSRAATYSSEWFPKIMKSLMNIYPSLPP--LQWLKQAYNEISLQFK----MYINNERPDLKYCG
 | |. ||| ..|  .  . .   ..  ...|||| |  ||.. .|   . .|   ... | |.  |. ...|. ..  . |     . .... .|   |
qGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllstaG

ATAASLLITRDFYCVSNIGDTRIVLCQKDG-----TAKRLSFDHKPSDPSETKRISRLGGFVVSNQHTSRV---------NGT--------LAVSRSIGD
.||. ..|.|.   |...|| .||| .|.      .|| |  ||||..|.|..|| .||| |  ..  .||         ||         |||.||.||
ttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaRslGD

IY-----MEPFVV-PDPYLSQTNRNFEMDKYLIVACDGIWDEISDQQACNIVLNSNSTDEA
..     .. ||| |.|........ . .|..|.| ||.|. .. ..| ..| ..... | 
lWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkel
PP2C_2 Protein phosphatase 2C 1131-1319 4.6e-08 25.6 Pfam-A 21-183 (212) alignment 
Range on Protein: 1131-1319
Range on HMM: 21-183/212.0
GDDYDLISLFDGHAGSRAATYSSEWFPKIMKSLMNIYPSLPPLQ----WLKQAYNEISLQF--KMYINNERPDLKYCGATAASLLITRDFYCVSNIGDTR
 .|..|.   ||.   . .   .... ... . .  . .   .|    .|.|. |||. .   |   . .. .||  ..|   ..|| .. .. .|||..
asdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDga

IVLCQKDGTAKRLSFDHKPSDPSETKRISRLggF----VvsnqhtsrvngtlavsrsigdiymepfvvpdpylsQTNR-NFEMDKYLIVACDGIWDEISD
||. ..||....|. ...    .|| ....        .                                   ...| ..|  . |..  ||..|....
ivvrdrdgevqllgepdsgeyanettfltse..daeeel...................................rirrlklepgdalllmTDGvsdslrk
PP2C_2 Protein phosphatase 2C 1131-1319 4.6e-08 25.6 In-house 21-183 (212) alignment 
Range on Protein: 1131-1319
Range on HMM: 21-183/212.0
GDDYDLISLFDGHAGSRAATYSSEWFPKIMKSLMNIYPSLPPLQ----WLKQAYNEISLQF--KMYINNERPDLKYCGATAASLLITRDFYCVSNIGDTR
 .|..|.   ||.   . .   .... ... . .  . .   .|    .|.|. |||. .   |   . .. .||  ..|   ..|| .. .. .|||..
asdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDga

IVLCQKDGTAKRLSFDHKPSDPSETKRISRLggF----VvsnqhtsrvngtlavsrsigdiymepfvvpdpylsQTNR-NFEMDKYLIVACDGIWDEISD
||. ..||....|. ...    .|| ....        .                                   ...| ..|  . |..  ||..|....
ivvrdrdgevqllgepdsgeyanettfltse..daeeel...................................rirrlklepgdalllmTDGvsdslrk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 1132-1359 8.9e-31 99.8 In-house 31-276 (276) alignment 
Range on Protein: 1132-1359
Range on HMM: 31-276/276.0
DDYDLISLFDGHAGSRAATYSSEWFPKIMKSLMNI--YPSLPPLQWLKQAYNEISLQFKMY--INNERPDLKYCGATAASLLITRDF----------YCV
 .  |...||||||  ||  ... |||... |..   |      .  .. |.   |  ...  ....  | .| ||||.  |. .|             |
snialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqqqqqrylqv

SNIGDTRIVLCQKDGTAkRLSFDHKPSDPSETKRISRLGgFVVSNQHTsRVNGtLAVSRSIGDIYMEPF---VVPDPYLSQTNRNFEMDKYLIVACDGIW
.|.||.   |.. . .   ||.||| .||.| .||   |   .|.. | |.|| |||||..|| ..      .. .||.|.      .||.|||| ||.|
anvGdssaflsrGnesl.elskdhkatdpeekqrikddG.itlsdnqt.rinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlw

DEISDQQACNIVLN----SNSTDEACTKLKDYAYFS-GSDDNITVIVIKL
| || ..| ..|       .. |. .. | . |  |  . ||..|||.||
dvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_KAPP-like_pd Subfamily KAPP-like 1132-1359 3.2e-30 98.1 In-house 32-266 (266) alignment 
Range on Protein: 1132-1359
Range on HMM: 32-266/266.0
DDYDLISLFDGHAGSRAATYSSEWFPKIMKSLMNIYPSLPPLQWLKQAYNEISLQFKmYINNERPDLKYCGATAASLLITRD----FYCVSNIGDTRIVL
 .  |...||||||  ||  ... |||... |..        .   .  . .   ||  ....  | .| ||||.  |. .|    .  |.|.||.   |
snialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafk.evdaklkdfeyeGatatlalvwsdGqqrylqvanvGdssafl

CQKDGTAkRLSFDHKPSDPSETKRISRLGgFVVSNQHTsRVNGtLAVSRSIGDIYMEPF---VVPDPYLSQTNRNFEMDKYLIVACDGIWDEISDQQACN
.. . .   ||.|||  ||.| .||   |   .|.. | |.|| |||||..|| ..      .. .||.|.      .||.|||| ||.|| || ..| .
srGnesl.elskdhkakdpeekqrikddG.itlsdnqt.rinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaie

IVLN----SNSTDEACTKLKDYAYFS-GSDDNITVIVIKL
.|       .. |. .. | . |  |  . ||..|||.||
kvkslydqqatedkmasslletaiqsikakdnvsvivvkl
PP2C_SIG_SM00331 1132-1359 9.3e-09 28.1 In-house 28-217 (217) alignment 
Range on Protein: 1132-1359
Range on HMM: 28-217/217.0
DDYDLISLFDGHA-GSRAATYSSEWFPKIMKSLMNIypslpplQWLKQAYNEISLQFKMYinnerPDLKYCGATAASLL--ITRDFYCVSNIGDTRIVLC
... |. ..||.  | .|| .||.  ......| .        ..|.|| ...   ..        . |  .||.  .|  ....   . |.|| |..| 
egrlllvvaDgmGkGlaAaaassqlrtalrellseg.......eelsqalkrlnraiyee.....keekgmfaTlllalydfssgklsyanaGdsrpyll

QKDGTAKRLSFdhkpsdpsetkrisrlggfvvsnqhtsrvngT-----------LavsrsigdiymepfvvpdpyLSQTNRNFEMDKYLIVACDGIWDE-
..... ..|..                               .                                . ..... | .  |. . ||...  
rdgklveilkd...............................vegaplGlepevs....................vdirelelekgdllllytDGltear

----ISDQQACNIVLNS-NSTDEACTK-----LKDYAYFSGSDDNITVIVIKL
    . ... ..|.  . .|.... ..     |  .|  |.  |.|||.|.|.
sekgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvvkv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 1137-1293 4e-16 52.4 In-house 24-196 (292) alignment 
Range on Protein: 1137-1293
Range on HMM: 24-196/292.0
ISLFDGHA--GSRAATYSSEWFPKimkslmNIYPSLPPLQWLKQAYNEISLQFKMYINNERPDLKYCGATAASLLITRDF--YCVSNIGDTRIVLCQ---
 ...|||   | . | .. . . .      ..  . ..|| | .|     |.    ...   | .  ..||.   ..||     ..|.||.| .| .   
aavldGhGvnGdkvaqlaedtlev......elleltrqlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclg

-KDGTAKRLSFDHKPSDPSETKRISRLGGFVV-------SNQHTSRV------NGTLAVSRSIGDIYM-EPFVVPDPYL
  |   . || ||||.|| | .|| | ||.|          . |.||      .| ||.||..||... |  || .| |
gsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePel
subfamily_PDP_pd Subfamily PDP 1200-1281 7.6e-06 18.3 In-house 151-238 (398) alignment 
Range on Protein: 1200-1281
Range on HMM: 151-238/398.0
YCGATAASLLITRDFYCVSNIGDTRIVLCQKDGT----AKRLSFDHKPSDPSETKRISRLGGfvVSNQ----HTSRVNGTLAVSRSIGDI
  ||.|   ||  .   | |.||.| ||......    |..|| |.  . ..| .|| .      ...    ...|. |.|. .|  ||.
lsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHP..geesktvirngRlLgeLqPlRAFGdv
subfamily_PPM1G_pd Subfamily PPM1G 1201-1343 1.5e-26 86.4 In-house 296-448 (473) alignment 
Range on Protein: 1201-1343
Range on HMM: 296-448/473.0
CGATAASLLITRDFYCVSNIGDTRIVLCQKdGTAKRLSFDHKPSDPSETKRISRLGGFVVSNqhtSRVNGTLAVSRSIGDI-YMEPFVV--PDPYLS---
 |.||   |.  .   | |.||.| ||... |.|  || |||| |. |..|| . || | ..    |||| | .|| .||  | .   .   .  .|   
sGttAvvaLlkekklivAnaGDsRcvlsrn.GkAldlslDHkPeDevEleRiekAGGkvded...gRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlP

--QTNRNFEMDKYLIVACDGIWDEISDQQACNIVLNS---N---STDEACTKLKDYA
  ...   | |..|..||||||. .. |.  . | .    .   .  |....| | .
DikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDac
subfamily_PP2D1_pd Subfamily PP2D1 1215-1328 3.3e-19 62.0 In-house 190-304 (492) alignment 
Range on Protein: 1215-1328
Range on HMM: 190-304/492.0
YCVSNIGDTRIVLCQKdGTAKRLSFDHKPSDPSETKRISRLGGFVVSNQHTSRVNGTLAVSRS---IGDIYMEPFVVPDPYLSQTNRNfEMDKYLIVACD
  ..|.|... |||.. | |..|  .| | .. | .|... |. ||... ...||| | . |    .||  ..  |.|.|..  .. . | ...|..|  
lyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkld.eaaqflvlAsn

GIWDEISDQQACNIVLN
|.|. .|...  ..| .
GlWevlseeevlsLvkq
subfamily_PHLPP_pd Subfamily PHLPP 1217-1359 3.2e-15 48.7 In-house 109-245 (246) alignment 
Range on Protein: 1217-1359
Range on HMM: 109-245/246.0
VSNIGDTRIVLCQKDGtAKRLSFDHKPSDPsETKRISRLGGFVVSNqhtSRVNGTLAVSRSIGDIYMEPFVVPDPYLSQTNRNfEMDKYLIVACDGIWDE
| ..|    ||. .     |||  .. ..  | |||    ...  .   ...|| .. .| .| ... |.|.|.| ....  . | | .|||  . .|. 
vAsvGtlqavliRngk.klrlsksyviekd.elkrikeakaiited...nkingviestrllGytflfPvvlPkphvrevlLt.eqdellivGnkalWev

ISDQQACNIVLNSNSTDEACTKLKDYAYFSGSDDNITVIVIKL
.| ..| . | . ...  |  || | |   | .|...|.|..|
lsideaveavrkeedplvaAkklvdlaqsygaadsvsvlvvrl
subfamily_PPM1H_pd Subfamily PPM1H 1260-1328 7.2e-08 24.6 In-house 269-349 (404) alignment 
Range on Protein: 1260-1328
Range on HMM: 269-349/404.0
VSNQHTSRVNGTLAVSRSIGD---------IYMEPFVVPDPYLSQTN---RNFEMDKYLIVACDGIWDEISDQQACNIVLN
. . . .|. .|..|.| .||         ... ||. | | .....    . . |. ||.| ||.|| .|.... .|| .
sgegkkaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivre
PPM_PTC7_SpoIIE_motif 1304-1358 4.8e-06 20.2 In-house 13-79 (81) alignment 
Range on Protein: 1304-1358
Range on HMM: 13-79/81.0
KYLIVACDGIW-------DEISDQQACNIVL--NSNSTDEACTKLKDYAYFSG---SDDNITVIVIK
  |....||..       . ....... ..    ..| .|.. || | .   |   ..|.||..|..
dvllLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevlengsgereDDitllvlr
PPM_PTC7_motif 1307-1352 2.2e-11 37.1 In-house 1-51 (51) alignment 
Range on Protein: 1307-1352
Range on HMM: 1-51/51.0
IVACDGIWDEISDQQACNIVLNSNS-----TDEACTKLKDYAYFSGSDDNI
| |.||.|| .|||.|...|    |       ||..|| |.|   ||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni