Gene DDB_G0278499 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily LRR-PPM
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP103_AA protein Get Run
DdisP103_AA_399-690 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 399-487 1.1e-09 30.8 In-house 12-99 (473) alignment 
Range on Protein: 399-487
Range on HMM: 12-99/473.0
EESDGSRFKVGKSEMTGKRPTMEDRMVAYGNFRNNpnSELYCIFDGHGGRAASDFAADNIYKIFAEFLD-ANNTPEESFTKAYKSINTQI
|.   .....| | | | |  .||   .  .. ..   .|. ..|||||.. . . |... ... .    ...  |.....|. ......
edesneelsygasamqGwrvsqEDahncitdlded..tslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDekl
PP2Cc_SM00332 400-686 2.3e-65 213.7 In-house 4-274 (274) alignment 
Range on Protein: 400-686
Range on HMM: 4-274/274.0
ESDGSRFKVGKSEMTGKRPTMEDRMVAYGNFRNNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANNT-----PEESFTKAYKSINTQISPW----
.. ....  |||.| |.| .|||..| . .. .. .  ....|||||| ....|..........| |   ..     .||   ||..|.. .|       
sgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqsk

-P---FIGTTAASVYICENKVYIANVGDSRVVLGKIIGsdssgnsggggggsaegggdeqqqlqqqqqqqpqpqqqqkkttAERLTFDHRPVEESERLRI
 .     |.|| .... ....|.|||||||.||..                                              | .|. ||.| .|.|| ||
elenalsGstavvallkkedlyvanvGDSravlcrngk...........................................avqlsvdhkpedederkRi

TEAGGTVLNGRVNGMLAVSRALGDSFLT-------PYVIPDPHLSSFTISKDDKFLILACDGVWDLISDEEAVETIAGIS------DPNKAAETLRDLAY
 .|||.| .|||||.||||||.|| ||        ||....|. .  |. ..|.|||||.||.|| .|..|.|...  .       || .||| | ..|.
kkaggvvekgrvngglavsrafGdhflkknkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeai

NS-GSTDNISVCVV
.. ||.|||.|.||
rrggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 400-519 9.8e-17 54.2 In-house 6-141 (282) alignment 
Range on Protein: 400-519
Range on HMM: 6-141/282.0
ESDGSRFKVGKSEMTGKRPTMEDRMVAYGNFRNNPNSELYCIFDGHGGRAASDFAADNIYKIFAE---FL--DANNTP----EESFTKAYKSINTQIS--
...|  ...| |.| | | .|||. ..  .. . .. ... .||||.|. ......... .   |   .    .....    .| . ... ... .|.  
qaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairel

--PWP---FIGTTAASVYICENKVYIANVGDSRVVL
          |.|| .| . |....|||.|||| ||
stdlktadksGsTavtvlvsekhliianlGDsRavl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 401-690 5.5e-135 441.5 In-house 1-255 (255) alignment 
Range on Protein: 401-690
Range on HMM: 1-255/255.0
SDGSRFKVGKSEMTGKRPTMEDRMVAYGNFRNNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANNT-PEESFTKAYKSINTQISPWP-FIGTTAA
||.||||||.|.|.|.||||||..|.||.||.......|..|||||||||..||....|||.||.||.||. |..|..||||.|.||||..| |||||||
sdssrfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserpkfiGttaa

SVYICENKVYIANVGDSRVVLGkiigsdssgnsggggggsaegggdeqqqlqqqqqqqpqpqqqQKKTTAERLTFDHRPVEESERLRITEAGGTVLNG--
||.|.|.||||||||||||||.                                          ||..||.||..||.|.||||..||.|.||||...  
svliiedkvyianvGdsrvvlc..........................................qkdgtakrlsldhkPseeseekriselGGtvvstvv

--RVNGMLAVSRALGDSFLTPYVIPDPHLS-SFTISKDDKFLILACDGVWDLISDEEAVETIAGISDPNKAAETLRDLAYNSGSTDNISVCVVKLSD
  ||||.||||||||||||.|.|.|||.|| |..|||.||||||||||.|||||||||||..||||||.||||.||||||.|||||||||.|.||||
tsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisviviklsd
subfamily_PPM1G2_pd Subfamily PPM1G2 402-521 4.3e-18 58.3 In-house 15-143 (287) alignment 
Range on Protein: 402-521
Range on HMM: 15-143/287.0
DGSRFKVGKSEMTGKRPTMEDRMVAYGNFR---NNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDAN-NTPEESFTKAYKSINTQISPW-----PF
. . .||| | | | | .|||  .   ..    ....  |. .||||||.... .|. .. |. |.  . . .. |. . .|........          
analtkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkdes

IGTTAASVYICENKVYIANVGDSRVVLGK
 |.|| .| | |.|.|.||.|||| || .
aGstavvvlikeeklyvanaGDsravlss
0034914 PP2C-like 404-690 1.5e-72 236.8 In-house 19-292 (295) alignment 
Range on Protein: 404-690
Range on HMM: 19-292/295.0
SRFKVGKSEMTGKRPTMEDRMVAYGNFRN-NPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDA--------NNTPEESFTKAYKSINTQISPWPFI-
 ...|| . ..|.|...||..... |. . ...  |...|||||| ||...|.........|.|           ...||...||..... ..  .    
lllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr

------GTTAASVYICENKVYIANVGDSRVVLGkiigsdS---SgnsggggggsaegggdeqqqlqqqqqqqpqpqqqqkkttaERLTFDHRPVEESERL
      ||||  ..|..||.|.|||||||.||       .                                            ..||.||.|| |.|| 
pelagsGtTavvalirgnklyvanvGDSravll......rngel........................................vqltvdhkpvnelere

RITEAGGTVLNGRVNGMLAVSRALGDSFLT---------PYVIPDPHLSSFTIS-KDDKFLILACDGVWDLISDEEAVETIAG----ISDPNKAAETLRD
|| .|||.| .|||||.|||.||||| .|          |.|.. |........ .||.||.||.||.|| .|.||.|. ..       |...||| | |
rilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvd

LAYNSGSTDNISVCVVKLSD
||.. ||.|||.|.||.|..
lAlargsrDNiTvvvvrlng
0049733 PP2C-like 405-520 2.5e-21 69.3 In-house 2-119 (235) alignment 
Range on Protein: 405-520
Range on HMM: 2-119/235.0
RFKVGKSEMTGK-RPTMEDRMVAygnfrnnpNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANNT--PEESFTKAYKSINTQISP-------WPFIG
|..|| . ..|. |...||....        .  |....||||| ||...|.........|.| . ..  .||...||.. .|...         .   |
rlsvgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmg

TTAASVYICENKVYIANVGDSRVVLG
|||. ......|.|.|||||||..| 
tTavvalldggklyvanvGDsrayll
subfamily_ILKAP_pd Subfamily ILKAP 406-662 4.7e-39 127.3 In-house 5-246 (293) alignment 
Range on Protein: 406-662
Range on HMM: 5-246/293.0
FKVGKSEMTGKRPTMEDRMVAYGNFRNN---PNS-----ELYCIFDGHGGRAASDFAADNIYKIFAEFLDANNTPE------ESFTKAYKSINT------
.|   .|  |.| .|.| .|   .. ..   ..|       |..||||.|. ||.|||... |   | |  ...         ......|  .       
lkgayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLkla

-QISPWPFIGTTAASVYICENKVYIANVGDSRVVLGKIIGSDSSgnsggggggsaegggdeqqqlqqqqqqqpqpqqqqkkTTAERLTFDHRPVEESERL
 .  |    |.||..| . .| .|.||.|||. || .   . .                                      ... .|| || ||.. || 
skakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdk.....................................iasvvLtkdhtpvkyeerk

RITEAGGTVLNGRVNGMLAVSRALGDS-FLTPYVIPDPHLSSFTISKDDKFLILACDGVWDLISDEEAVETIAGISDPN
||  |||.| .|||.|.| |||..||  | .  ||  |...  .....|.|..|||||.|. .| .|.|. |  . . .
riqkaGgvvrdgrvlGvlevsrsiGdgrfkrlGvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvlede
PPM_PTC7 407-681 1.4e-57 188.1 In-house 2-259 (259) alignment 
Range on Protein: 407-681
Range on HMM: 2-259/259.0
KVGKSEMTGKRPTMEDRMVAYGNFR---NNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANNT--PEESFTKAYKS--INTQISP------WPFI
..| |.. | | .|||...|. |..    . . .....||||||| |...|. .. .| .|  . ...  .|. ..|.. .  ..  .            
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepsts

GTTAASVYICENKVYIANVGDSRVVLGKIIGSDssgnsggggggsaegggdeqqqlqqqqqqqpqpqqqqkkttaERLTFDHRPVEESERLRITEAGGTV
|.|| ...| ..|.|.|||||||.||..  ..                                            .||.||.|..|.|| ||..|||.|
GstAvvalitgsklyvAnvGDSravLcrsgnav..........................................kqltedHkpsnedEreRiegaggsv

L---NGRVNGMLAVSRALGDSFLTP------YVIPDPHLSSFTISKDDKFLILACDGVWDLISDEEAVETIAGI-SD--PNKAAETLRDLAYNSGSTDNI
    ||||||.||||||.|| .| |      .|...|. || .|...|.|||||.||.|| .||.|||. .    |.  |..||| |.| |...||.|||
snvgngrvngvlavsRafGdfelkpketeeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
PPM_PTC7_SpoIIE 407-672 1.1e-30 100.2 In-house 2-213 (230) alignment 
Range on Protein: 407-672
Range on HMM: 2-213/230.0
KVGKSEMTGKRPTMEDRMVAYGNFR---NNPNSELYCIFDGHGGRAasDFAADNIYKIFAEFLDANNT-PEESFTKAYKSINTQIspWPF---IGTTAAS
..| |.. | | .|||..... |..    .    .....|||||||   .|.  . ....|. .|. . ||| .....  .....  . .    |.||  
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlalaadl..edepsssgaTavv

VYICENK--VYIANVGDSRVVLGKIiGSDssgnsggggggsaegggdeqqqlqqqqqqqpqpqqqqkkttaerltfdhrpveesERLRItEAGGTV-L--
..|  ..  .|.||.|||...| .  .                                                         || || .||| . |  
alidpstgklyvanaGdsppllvrd.dgg.......................................................ereri.vagglpslGi

-NGRVNGMLAVSRALGDSFLTP---YVIPDPHlSSFTISKD-DKFLILACDGVWDLISDEEAVETIAGISDPNkaaetlrdlA
 .|||.| ||||.| || .| .   .| . |. .| .. .. |.|||||.||.||  |..|.|...    ...         |
lpgrvfgvlavslapGdllllytDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.........a
PP2C Protein phosphatase 2C 407-521 7.9e-19 61.2 Pfam-A 2-128 (255) alignment 
Range on Protein: 407-521
Range on HMM: 2-128/255.0
KVGKSEMTGKRPTMEDRMVAYGNFR---NNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANNT--PEESFTKAYKS-INTQISP------WPFIG
.||.||..| | .|||...|. |..    . . .....||||||| |...|. .. .| .|  . .     |. . |.. . .. ..            |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksG

TTAASVYICENKVYIANVGDSRVVLGK
.|| ...| ..|.|.|||||||.||..
stavvalirgkklyvAnvGDSravLcr
PP2C Protein phosphatase 2C 407-521 7.9e-19 61.2 In-house 2-128 (255) alignment 
Range on Protein: 407-521
Range on HMM: 2-128/255.0
KVGKSEMTGKRPTMEDRMVAYGNFR---NNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANNT--PEESFTKAYKS-INTQISP------WPFIG
.||.||..| | .|||...|. |..    . . .....||||||| |...|. .. .| .|  . .     |. . |.. . .. ..            |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksG

TTAASVYICENKVYIANVGDSRVVLGK
.|| ...| ..|.|.|||||||.||..
stavvalirgkklyvAnvGDSravLcr
subfamily_PPM1K_pd Subfamily PPM1K 407-520 5.1e-13 41.7 In-house 5-126 (263) alignment 
Range on Protein: 407-520
Range on HMM: 5-126/263.0
KVGKSEMTGKRPTMEDRMVAYgnfRNNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANNTPEESFTKAYKSINTQISPWP-FI---------GTT
.|||  . |||   |||.      . .|.   ...||||.| || ||. |.. ||  ..|. ..  |. ...|.. ...... .  |          |||
svGkdsliGkraenedriklk...eldpellyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGtt

AASVYICE-NKVYIANVGDSRVVLG
|. . . . ... .|..|||| .| 
atvsllrdGtelvlaslGdsrailc
subfamily_PPM1E_pd Subfamily PPM1E 408-519 9e-17 54.1 In-house 6-128 (265) alignment 
Range on Protein: 408-519
Range on HMM: 6-128/265.0
VGKSEMTGKRPTMEDRMVAYGNF------RNNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANNTPEESFTKAYKSINTQISPW-----PFIGTT
|    . .|| .||||.||. ..      .....   . .||||||  |...|| ....  ..  .... |.| . .|.| .....           |.|
vsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklksGst

AASVYICENKVYIANVGDSRVVL
| .| | ....|.| .|||...|
avvvliekdqlyvaWlGDsqall
subfamily_PPM1D_pd Subfamily PPM1D 411-521 2.6e-15 49.3 In-house 7-136 (309) alignment 
Range on Protein: 411-521
Range on HMM: 7-136/309.0
SEMTGKRPTMEDRMVAYGNFRNNP---NSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANNT--------PEESFTKAYKSINTQISPWPF-------
.   | |. |||... . . ...    .     .||||||. |. || .....   .  .  ..         .|.| .  .... . . ||        
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksglls

-IGTTAASVYICENKVYIANVGDSRVVLGK
  ||||. | |...|.|.|.||||..|||.
taGttasvviirreklyvahvGDsaivlgv
subfamily_PPM1L_pd Subfamily PPM1L 412-521 2.2e-14 46.4 In-house 11-134 (269) alignment 
Range on Protein: 412-521
Range on HMM: 11-134/269.0
EMTGKRPTMEDRMVAYGNFRNNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFL---DANNTP-----------EESFTKAYKSINTQISPWPFIGTTA
 . |.|| ||||.    . .|. . .....||||||  |..|| | . |   . |   ||.              .| ..  .| ...  .     ||||
svlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGtta

ASVYICENKVYIANVGDSRVVLGK
    . |... .||||||| ||  
lialvqesdlivanvGdsrGvlyd
subfamily_PP2D1_pd Subfamily PP2D1 418-470 7e-09 27.9 In-house 15-67 (492) alignment 
Range on Protein: 418-470
Range on HMM: 15-67/492.0
PTMEDRMVAYGNFRNNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANN
 .|||. .   .| |..||  . |.||. |..| . || .. ....| |.  .
skmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvd
Subfamily Dicty-PPM1L-like 421-688 3.4e-19 61.8 In-house 22-303 (305) alignment 
Range on Protein: 421-688
Range on HMM: 22-303/305.0
EDRMVAYGNFRNNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANNTPEESFTKAYKSINTQISPWPFIGTTAASVYIC--ENKVYIANV--GDSR
|||        .. .  |. .||||.|  |....  ....|. ...  |     .  .  ..  ..     .  |   |.  .  .||   . .    . 
edrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnkkaGttlngssas

VVLGK---IIGSDSSGNSGGGGGGSAEGGGDEQQQLQQqQQQQPQpqqqqkKTTAERLtFDHRPVEESERLRITEAGGTVLNG---RVNGMLAVSRALGD
|.| .   |  . |....    |..|||    .        . |           ..| ...  . . .| ||  ......|    .||..| .||  ||
vilerertivstasdtevvlssGaiaeglsiinsPkgv.gfdspg......wmkfnhl.ynqnnfldeiririeslqaalynygellvnrllkksrskGd

SFLTPYVIPDPHLSSFTISK-DDKFLILACDGVWDLISDEEAVETIAGIS-----------DPNKAAETLRDLAYNSGSTDNISVCVVKL
  |. .|||..    . ..| .|.||.|| ||.|. .| .. || .  .            |.|   .    .|.. || ||| . ..||
knlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgDnitlviikl
Zn_ribbon_2 Putative zinc ribbon domain 421-490 4.1e-06 13.6 Pfam-A 11-80 (81) alignment 
Range on Protein: 421-490
Range on HMM: 11-80/81.0
EDRMvAYGNFRNNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANN-TPEESFTKAYKSINTQISPW
|..   .|.  .. .|| ||..  . |.  .|.  ... .. |.||. .|   || ..| .|.. .... |
eeee.llgteadgskseeYCkyCykdgkfteditmeemiekcakflkeenklteeearkilkellpkLkrW
PP2C_SIG_SM00331 428-519 3.8e-07 22.9 In-house 22-114 (217) alignment 
Range on Protein: 428-519
Range on HMM: 22-114/217.0
GNFRNNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDANNTPEESFTKAYKSINTQ-ISPWPFIGTTAASVYICENKVYIANVGDSRVVL
. . .|  . |. ..||.|. .|.  |.  . . . |.|........ . .. . |. .      |.  ..| . . ..|...||.||||..|
dvvklnegrlllvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyeekeekgmfaTlllalydfssgklsyanaGdsrpyl
subfamily_KAPP-like_pd Subfamily KAPP-like 431-520 2.7e-08 26.2 In-house 29-131 (266) alignment 
Range on Protein: 431-520
Range on HMM: 29-131/266.0
RNNPNSELYCIFDGHGGRAASDFAADNIYKIFAEFLDA---------NNTPEESFTKAYKSINTQISPWPFIGTTAASVYICEN--K--VYIANVGDSRV
 |  |  |...|||| |. |.| | . . |.. . |.          .    . . .|.|....... . . |.||. . . ..  .  . .||||||  
sncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdGqqrylqvanvGdssa

VLG
 | 
fls
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 438-525 7.7e-09 28.5 In-house 23-118 (292) alignment 
Range on Protein: 438-525
Range on HMM: 23-118/292.0
LYCIFDGHG--GRAASDFAADNIYKIFAEFLDANNTPEESFTKAYKSINTQISPW----PFIGTTAASVYICEN--KVYIANVGDSRVVLGKIIGS
|  ..||||  |.. ...|.|.. . . |    .    |.. .   .| ...          .|||.   .  .  ....|||||||..||...| 
laavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclgg
subfamily_PDP_pd Subfamily PDP 473-668 4.5e-16 51.9 In-house 132-321 (398) alignment 
Range on Protein: 473-668
Range on HMM: 132-321/398.0
EESFTKAYKSINTQISPWPFIGTTAASVYICENKVYIANVGDSRVVLGKIigsDSSGNsGGGGGGSAEGGGDEQQQLQQQQQQQPQPQQqQKKTTAERLT
.|...|. ... ..     . |..|  ..| ......||.||.| |||.    . .|.       |..  .| .. ..  ... |. .. .     .|| 
tealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvq...eeegs.weavkLskdqtadneeEveRikkeHPgees.ktvirngRlL

FDHRPVEE--SERLRITE-AGGTVLNGrvngmLAVSRALGDSFLT-PYVIPDPHLSSFTISKDDKFLILACDGVWDLISDEEAVETIAGISDPNKAAETL
    |.      |....|    .||.        . .   ... | ||.. .| . |  ....||||.|| || |||.|.||.|...    . .|..| .
geLqPlRAFGdvryKwseelqkkvlek.....aylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv
subfamily_PPM1G_pd Subfamily PPM1G 494-655 3.2e-26 85.4 In-house 297-425 (473) alignment 
Range on Protein: 494-655
Range on HMM: 297-425/473.0
GTTAASVYICENKVYIANVGDSRVVLGKIigsdssgnsggggggsaegggdeqqqlqqqqqqqpqpqqqqkkTTAERLTFDHRPVEESERLRITEAGGTV
||||  . . |.|...||.|||| || .                                             .|  |  ||.| .| |. || .|||.|
GttAvvaLlkekklivAnaGDsRcvlsrn...........................................GkAldlslDHkPeDevEleRiekAGGkv

L-NGRVNGMLAVSRALGDSFLTP---------YVIPDPHLSSFTISKDDKFLILACDGVWDLISDEEAVETI
  .||||| | .|||||| .             .   | .   |. ..|.||.|||||.|. .. .| |. .
dedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 544-688 1.9e-20 65.9 In-house 118-276 (276) alignment 
Range on Protein: 544-688
Range on HMM: 118-276/276.0
DEQQQLQQQQQQQPQPQQQ----QKKTTAERLTFDHRPVEESERLRITEAGGTVLNG--RVNGmLAVSRALGDSFLTPY---VIPDPHLSS-FTISKDDK
.|||| ||.  |  .  .      .   .  |..||.  . .|. || . | |. ..  |.|| ||||||||| |.      .| .|..|. ....  ||
eeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdk

FLILACDGVWDLISDEEAVETIAGISDPNK----AAETLRDLAYNSG-STDNISVCVVKL
|||.| ||.||.|| ..|.| .  . | ..     |..| . | .|  . ||.|| ||||
flivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_PPM1D_pd Subfamily PPM1D 559-662 5.3e-12 38.4 In-house 139-268 (309) alignment 
Range on Protein: 559-662
Range on HMM: 139-268/309.0
PqqQQKKTTAERLTFDHRPVEESERLRITEAGGTVLNG----RV---------NGM--------LAVSRALGD-----SFLTPYVI-PDPHLSSFTISKD
|  ..|| .|. || ||.| . .|. || |.|| | .     ||         ||         |||.|.|||     ..   .|. |.|... .|.  .
p..kekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpn

D-KFLILACDGVWDLISDEEAVETIAGISDPN
. ||.||| ||.|.... |.||...   .  .
eekfiilasDGlwnvltpedavsvvekeeekk
subfamily_PPM1A_pd Subfamily PPM1A 564-688 4.7e-39 127.4 In-house 143-280 (282) alignment 
Range on Protein: 564-688
Range on HMM: 143-280/282.0
KKTTAERLTFDHRPVEESERLRITEAGGTVLNGRVNGMLAVSRALGDSFLTP---------YVIPDPHLSSFTISKDDKFLILACDGVWDLISDEEAVET
....|..|| ||.| ...|. ||..|||.|...||||.||||||||| ..            |...|.  |. .|..|.||.|||||.|| .||||.|| 
rngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvel

IAGI----SDPNKAAETLRDLAYNSGSTDNISVCVVKL
..      ..... |..| | |.. ||.||.||.|| .
vrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
PP2C Protein phosphatase 2C 565-681 2.8e-41 134.8 Pfam-A 130-255 (255) alignment 
Range on Protein: 565-681
Range on HMM: 130-255/255.0
KTTAERLTFDHRPVEESERLRITEAGGTVL-NGRVNGMLAVSRALGDSFLTP----YVIPDPHLSSFTISKDDKFLILACDGVWDLISDEEAVETIAGI-
.... .||.||.| .|.|| ||.||||.|  ||||||.||||||||| .| |    .|...|...|......|.|||||.||.||..||.|||. .    
dnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrsel

SD---PNKAAETLRDLAYNSGSTDNI
|.   |..||| |.| |...||.|||
skkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 565-681 2.8e-41 134.8 In-house 130-255 (255) alignment 
Range on Protein: 565-681
Range on HMM: 130-255/255.0
KTTAERLTFDHRPVEESERLRITEAGGTVL-NGRVNGMLAVSRALGDSFLTP----YVIPDPHLSSFTISKDDKFLILACDGVWDLISDEEAVETIAGI-
.... .||.||.| .|.|| ||.||||.|  ||||||.||||||||| .| |    .|...|...|......|.|||||.||.||..||.|||. .    
dnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrsel

SD---PNKAAETLRDLAYNSGSTDNI
|.   |..||| |.| |...||.|||
skkkspmeaaeelvdeaiargsedni
subfamily_PPM1E_pd Subfamily PPM1E 565-688 2.9e-32 104.9 In-house 131-262 (265) alignment 
Range on Protein: 565-688
Range on HMM: 131-262/265.0
KTTAERLTFDHRPVEESERLRITEAGGTVLN---GRVNGMLAVSRALGDSFLTPYVIPDPHLSSFTISKDDKFLILACDGVWDLISDEEAVETIAG-ISD
|..| .|.  |.| .| |. || ||||.|..    ||||.|.||||.||  | |||. .. ...... .....|||||||.|| . .||.|...   ..|
kgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveeflad

----PNKAAETLRDLAYNSGSTDNISVCVVKL
     ...|..| . |.. ||.|||.| || |
gaedlsevakllveaakeagssDnitvvvvfl
subfamily_PPM1G2_pd Subfamily PPM1G2 565-688 2.3e-24 78.8 In-house 144-286 (287) alignment 
Range on Protein: 565-688
Range on HMM: 144-286/287.0
KTTAERLTFDHRPVEESERLRITEAGGTVLNGRVNGMLAVSRALGDS-FLTPY--------VIPDPHLSSFTISKDDKFLILACDGVWDLISDEEAVETI
|.... |.|||.| ||||. ||..|||.|  .|||| ||.||||||  | .          |   | .    ...|| ||.|||||.||.....| |. .
kgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlv

A----GISDPNKAAETLRDLAYNSGST------DNISVCVVKL
        .... .|.| | . .  |       ||..|..| |
rerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
subfamily_PPM1K_pd Subfamily PPM1K 565-689 9.2e-23 73.7 In-house 128-259 (263) alignment 
Range on Protein: 565-689
Range on HMM: 128-259/263.0
KTTAERLTFDHRPVEESERLRITEAGGTVL-----NGRVNGMLAVSRALGDSFLTPY-VIPDPHLSSFTI-SKDDKFLILACDGVWDLISDEEAVETIAG
.  |..|| || |  | |. || .|||.|      . .|||.||..|.|||  | .| || .|.  |. .  ..| ||.|  ||. ......|  . .  
nGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrl

ISDPNKAAETLRDLAYNSGSTDNISVCVVKLS
  ||..||..| . | . || || .. || | 
chdpeeaahalteqalqygsednatavvvplg
0049733 PP2C-like 566-688 8.8e-32 103.4 In-house 122-233 (235) alignment 
Range on Protein: 566-688
Range on HMM: 122-233/235.0
TTAERLTFDHRPVEESERLRITEAGGTVlngRVNGMLAVSRALGDSFLTpyvipdPHLSSFTISKDDkFLILACDGVWDLISDEEAVETIAGiSDPNKAA
 ....||.||.|| | || ||..||| |   ||.|.||..|||||..|       |..........| ||.||.||.|| .||||.|.....  |...||
gklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk......pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.ldleeaa

ETLRDLAYNSGSTDNISVCVVKL
|.| .||.. |..|||.| ||.|
erlvelalarggrDNiTvvvvrl
subfamily_PPM1L_pd Subfamily PPM1L 566-689 5.7e-27 87.6 In-house 137-267 (269) alignment 
Range on Protein: 566-689
Range on HMM: 137-267/269.0
TTAERLTFDHRPVEESERLRITEAGGTV-LNG--RVNGMLAVSRALGDSFLT--PYVIPDPHLSSFTISK-DDKFLILACDGVWDLISDEEAVETIA-GI
 .|  |.|||.| .  || || .||| . ..|  ||.|.||.||||||  |     ||.|| . .| . . . .|||||.||.|| .|.||||. |   .
GkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerl

SDPNKAAETLRDLAYNSGSTDNISVCVVKLS
..|.  | .|   ... ||.|||.| ||||.
kepdfGakslvlesfkrGsvdnitvlvvklk
subfamily_PP2D1_pd Subfamily PP2D1 567-655 7.5e-17 54.2 In-house 207-302 (492) alignment 
Range on Protein: 567-655
Range on HMM: 207-302/492.0
TAERLTFDHRPVEESERLRITEAGGTVL----NGRVNGMLAVSRAL---GDSFLTPYVIPDPHLSSFTISKDDKFLILACDGVWDLISDEEAVETI
 | .|| .| |  . || |.. ||..|     ||.|||.| . | |   ||  |   |||.|.. | .. . ..||.||  |.|. .|.|| .. .
kaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnGlWevlseeevlsLv
subfamily_KAPP-like_pd Subfamily KAPP-like 570-688 1.8e-20 66.1 In-house 138-266 (266) alignment 
Range on Protein: 570-688
Range on HMM: 138-266/266.0
RLTFDHRPVEESERLRITEAGGTVLNG--RVNGmLAVSRALGDSFLTPY---VIPDPHLSS-FTISKDDKFLILACDGVWDLISDEEAVETIAGISDPNK
 |..||.  ...|. || . | |. ..  |.|| ||||||||| |.      .| .|..|. ....  |||||.| ||.||.|| ..|.| .  . | ..
elskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqa

----AAETLRDLAYNSG-STDNISVCVVKL
     |..| . | .|  . ||.|| ||||
tedkmasslletaiqsikakdnvsvivvkl
subfamily_PHLPP_pd Subfamily PHLPP 579-688 4.7e-21 67.8 In-house 135-245 (246) alignment 
Range on Protein: 579-688
Range on HMM: 135-245/246.0
EESERLRITEAGGTVL-NGRVNGMLAVSRALGDSFLTPYVIPDPHLSSFTISKDDKFLILACDGVWDLISDEEAVETIAGISDPNKAAETLRDLAYNSGS
|. |  || || . .  ....||... .| ||  || |.|.|.||... .....| .||.  . .|. .| .||||..    ||  ||  | |||   | 
ekdelkrikeakaiitednkingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavrkeedplvaAkklvdlaqsyga

TDNISVCVVKL
.|..|| ||.|
adsvsvlvvrl
subfamily_PPM1H_pd Subfamily PPM1H 596-658 7.8e-06 17.9 In-house 275-350 (404) alignment 
Range on Protein: 596-658
Range on HMM: 275-350/404.0
GRVNGMLAVSRALGDS---------FLTPYVIPDPHLSSFTIS----KDDKFLILACDGVWDLISDEEAVETIAGI
 |. . ..|.| |||          .. |.. | |... . ..    ..|. |||| ||.|| .|.||. |... .
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrev
PPM_PTC7_SpoIIE_motif 632-688 1.5e-08 28.2 In-house 12-80 (81) alignment 
Range on Protein: 632-688
Range on HMM: 12-80/81.0
DKFLILACDGVW-------DLISDEEAVETIAGI--SDPNKAAETLRDLAYNSG---STDNISVCVVKL
.  |.|..||..       .|...||......     .. ..|..|.| . . |   ..|.|.. |...
gdvllLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevlengsgereDDitllvlrv
PPM_PTC7_motif 636-681 5.1e-14 45.5 In-house 1-51 (51) alignment 
Range on Protein: 636-681
Range on HMM: 1-51/51.0
ILACDGVWDLISDEEAVE-TIAGISD----PNKAAETLRDLAYNSGSTDNI
|||.||.|| .||.|||.    ..|.    |..||| |.| | . ||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni