Gene DDB_G0283919 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily LRR-PPM
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP104_AA protein Get Run
DdisP104_AA_813-1074 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 814-1074 7.7e-74 241.0 In-house 15-291 (295) alignment 
Range on Protein: 814-1074
Range on HMM: 15-291/295.0
KGNSSRFIVGFADTIGRRSTMEDESVIYGTY-RGKHDEDYFALFDGHGGNDAAKAASEELHRILAEK-------LKLNHANPVKCLKESFLATHTLIGER
     .. ||.|...|||...||  ...  . .. .|  .|..|||||| .||. ||| |...|.|        | |.  .....|...|||..  . | 
sslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellel

GIR------CGTTAVVALFIGKKGYIANVGDSRAVLCRDGIAVRVSLDHKPNLPKEEERIRALGGNVVTttssagvvtSRVNGQLAVSRALGDSFLN---
...      .||||||||..|.| |.||||||||||.|.| .|... ||||. . | |||...|| |.          .||||.|||.||||| .|    
allrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh.........grvngvlavtRalGdfdlklll

------PFVTSEPDIHgpINLETHIKNQFMIIACDGIWDVISDEEAVSIAAP----IADPEKACIKLRDQAFSRGSTDNISVIVIRFP
      |.|..|||..  .   |. ...|...|.||.|||.|.||.|.|..       |.|.|. .| |.|..|||.|||.|.|.|..
slllleplvsaePdvt..vleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrln
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 815-1074 1.1e-132 434.0 In-house 1-254 (255) alignment 
Range on Protein: 815-1074
Range on HMM: 1-254/255.0
GNSSRFIVGFADTIGRRSTMEDESVIYGTYRGKHDEDYFALFDGHGGNDAAKAASEELHRILAEKLKLNHANPVKCLKESFLATHTLIGERGIRCGTTAV
..||||.|||.|.||||.|||||.||||..|.|.||||.||||||||..|||.|||||..||||.|.||.|||||.||... ...|.|.||....||||.
sdssrfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserpkfiGttaa

VALFIGKKGYIANVGDSRAVLC-RDGIAVRVSLDHKPNLPKEEERIRALGGNVVTTtssagVVTSRVNGQLAVSRALGDSFLNPFVTSEPDIHGpiNLET
..|.|..|.|||||||||.||| .||.|.|.||||||. ..||.||..|||.||.|     ||||||||.||||||||||||.|||...||...  .||.
svliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvst.....vvtsrvnGtlavsralGdsflePfvvpdPdlsq..slei

HIKNQFMIIACDGIWDVISDEEAVSIAAPIADPEKACIKLRDQAFSRGSTDNISVIVIRFP
..|..|.|.|||||||.|||||||.|.|.|.|||||..||||.|.|.|||||||||||...
skkdkflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisvivikls
subfamily_PPM1G_pd Subfamily PPM1G 815-899 2.4e-08 26.4 In-house 14-96 (473) alignment 
Range on Protein: 815-899
Range on HMM: 14-96/473.0
GNSSRFIVGFADTIGRRSTMEDESVIYgtYRGKHDEDYFALFDGHGGNDAAKAASEELHRILAEKLKLNHANPVKCLKESFLATH
. .... .|..   | |  .||          ..|   || .|||||.. ||  ...|  .| ..   .. .  |.|.|.|||  
esneelsygasamqGwrvsqEDahnci..tdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalD
PP2Cc_SM00332 816-1071 5.4e-66 215.8 In-house 6-274 (274) alignment 
Range on Protein: 816-1071
Range on HMM: 6-274/274.0
NSSRFIVGFADTIGRRSTMEDESVIYGTYRGKHDEDYFALFDGHGGNDAAKAASEELHRILAEKLKLNHA----NPVKCLKESFLATHTLIGERG-----
  .... |...  |.|..|||  |..  .  ..|  .|..||||||...|| .|..|...|.|.||        .. ..||..||.|.  | |       
snlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskel

--IRCGTTAVVALFIGKKGYIANVGDSRAVLCRDGIAVRVSLDHKPNLPKEEERIRALGGnvvtttssA---GvvtsRVNGQLAVSRALGDSFLN-----
   ..|.||||||. ... |.||||||||||||.| ||..| ||||. ..| .||.. ||            |    ||||.||||||.|| ||      
enalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg........vvekg....rvngglavsrafGdhflkknkkl

--PFVTSEPDIHGP-InletHIKNQFMIIACDGIWDVISDEEAVSIAAPIA------DPEKACIKLRDQAFSR-GSTDNISVIVI
  |..|.|||..   .      ...|.|.|.||.|||.|..|.|.|   .       ||..|. .| ..| .| ||.|||.|.|.
kepyitaepdvkvvtl....tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 816-1074 8.7e-63 205.3 In-house 8-281 (282) alignment 
Range on Protein: 816-1074
Range on HMM: 8-281/282.0
NSSRFIVGFADTIGRRSTMEDESVIYGTYRGKHDEDYFALFDGHGGNDAAKAASEELHRILAEK--------LKLNHANPVKCLKESFLATHTLIGE---
.   . .| . . |.|..|||. ..  .  . .|  .||.||||.|...|| ....|.. . |.         . .. .  . |...|||..  | |   
egnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelst

--R-GIRCGTTAVVALFIGKKGYIANVGDSRAVLCRDGIAVRVSLDHKPNLPKEEERIRALGGNVVtttssagvvTSRVNGQLAVSRALGDSFLNP----
  .   ..|.|||..|   |. .|||.|||||||||.| |.. . ||||. |||..||.. ||.||         .|||||.||||||||| ...     
dlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv.........vsRvnGaLAvsRalGDyeykeeeek

-----FVTSEPDIHgpiNLETHIKNQFMIIACDGIWDVISDEEAVSIAAPI----ADPEKACIKLRDQAFSRGSTDNISVIVIRFP
      |..||...    .| . ...|...||||||||.||||.|....       ..|. . .| |.|...||.||.||.|. |.
kaeeqlvsaepevt...sierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
subfamily_PPM1G2_pd Subfamily PPM1G2 816-1071 1.3e-46 151.8 In-house 15-284 (287) alignment 
Range on Protein: 816-1071
Range on HMM: 15-284/287.0
NSSRFIVGFADTIGRRSTMEDESVIY---GTYRGKHDEDYFALFDGHGGNDAAKAASEELHRILAEKLKLNHANPVKCLKESFLATHT-LIGE---RGIR
. . . || .   | | .|||  ..     . . ...  .||.||||||...|| |...|....|.| .... .  ..||..||.| . |. .   .   
analtkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkdes

CGTTAVVALFIGKKGYIANVGDSRAVLCRDGIAVRVSLDHKPNLPKEEERIRALGGNVvtttssagvVTSRVNGQLAVSRALGDS-FLNP--------FV
.|.||||.| . .| |.||.|||||||. .| .  .|.||||.  .|..|| | || |            ||||.||.||||||  | .          |
aGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfv.........elnrvngnLalsralgDfefkknvkkkpeeqiv

TSEPDIHgpiNLETHIKNQFMIIACDGIWDVISDEEAVSIAA----PIADPEKACIKLRDQAFSRGST------DNISVIVI
| .||.      . . .. |...||||||||....| | .        |.... . .| |.. .. |       ||..|...
tavPDvl...vkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvviv
subfamily_ILKAP_pd Subfamily ILKAP 820-1073 1.1e-32 106.4 In-house 5-292 (293) alignment 
Range on Protein: 820-1073
Range on HMM: 5-292/293.0
FIVGFADTIGRRSTMEDESVIYGTYRGK--HDE------DYFALFDGHGGNDAAKAASEELHRILAEKLKLNHANP-----VKCLKESFLATHTLI----
.   .|   | | .|.|. ||   .  .  ...       |.|.||||.|. |.. |.|.||. . |||  .. .       ||| .|| .|        
lkgayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLkla

--GERGIRCGTTAVVALFIGKKGYIANVGDSRAVLCRDG------IAVRVSLDHKPNLPKEEERIRALGGNVvtttssagvVTSRVNGQLAVSRALGDS-
  ..   . |.||.| | . .  |.||.|||.|||.|        ..|... ||.|   .| .||.  ||.|           .||.| | |||..||  
skakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvv.........rdgrvlGvlevsrsiGdgr

FLNPFVTSEPDIHgPINLETHikNQFMIIACDGIWDVISDEEAVSIAAPIADPE--------------------KACIKLRDQAFSRGSTDNISVIVIRF
| .  |.| ||..  ..|.    ..|...||||.|.|.| .|.|. .  . . |                     || .|  .|  |||.||..|.....
fkrlGvistPdvk.kceLten..dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvki
subfamily_PHLPP_pd Subfamily PHLPP 821-1073 4.5e-22 71.1 In-house 6-245 (246) alignment 
Range on Protein: 821-1073
Range on HMM: 6-245/246.0
IVGFADTIGRRSTMEDESViygtyrgkHDEDYFALFDGHGGNDAAKAASEELHRILAEKLKLNHANpVKCLKESFLATHTLIGERGIRCGTTAVVALFIG
 .|.... | .  .  ...        ..|  . ||||.  .. ..   . .. .|.|... ....  . .|  .|...  .|| | . |..|.. |   
siGlsesaGvknklcvaal........svealyGlfdGdrneelssllqrlmkdvlkeevqkdkne.eeymkntllvaqrklGeaGeklgsaallilirh

KK--------GYIANVGDSRAVLCRDGIAVRVSldHKPNLPKE-EERIRALGGnVVTTtssagvvTSRVNGQLAVSRALGDSFLNPFVTSEPDIHgpiNL
.|          .|.||   |||.|.|  .|.|  ..  . |.  .||.   . ..|         ...|| .. .| ||  || |.|  .| ..   ..
dkvdPaksfsLevAsvGtlqavliRngkklrls..ksyviekdelkrikeaka.iite.......dnkingviestrllGytflfPvvlPkphvr...ev

ETHIKNQFMIIACDGIWDVISDEEAVSIAAPIADPEKACIKLRDQAFSRGSTDNISVIVIRF
   ... ..|.  . .|.|.| .|||.      ||  |  || |.| | | .|..||.|.|.
lLteqdellivGnkalWevlsideaveavrkeedplvaAkklvdlaqsygaadsvsvlvvrl
subfamily_PPM1K_pd Subfamily PPM1K 822-1073 2.6e-42 137.8 In-house 6-258 (263) alignment 
Range on Protein: 822-1073
Range on HMM: 6-258/263.0
VGFADTIGRRSTMEDESVIYgtyRGKHDEDYFALFDGHGGNDAAKAASEELHRILAEKLKLNHaNPVKCLKESFLATHT---------LIGERGIRCGTT
||..  ||.|.  ||   .    . . .  |.|.||||.|  ||. . ..|..|| . |. .. .  . ||..|.  ..         .  .     |||
vGkdsliGkraenedriklk...eldpellyvavfdGhaGsaaadfvhdklekilkrllekek.dleivlknafeeldkklkrylefsvaeaellssGtt

AVVALF-IGKKGYIANVGDSRAVLCRDGIAVRVSLDHKPNLPKEEERIRALGGNVVTTtSSaGvvTSRVNGQLAVSRALGDSFLNPF-VTSEPDIHgPIN
| |.|.  |..  .|..|||||.|||.| | ... ||.|.| .|.|||.| ||.|  . |. |    .|||.||..|.|||  | .. | ..|. .  ..
atvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewn.sl.g..kplvngrlamtrslGdldlkryGviatPetk.slk

LEtHIKNQFMIIACDGIWDVISDEEAVSIAAPIADPEKACIKLRDQAFSRGSTDNISVIVIRF
.. | .. |...  ||| .|....|   .     |||.|   | .||.  || || ...|. .
vd.haadsflvlitdgisfvvnsqelcdlvrlchdpeeaahalteqalqygsednatavvvpl
0049733 PP2C-like 823-1073 7.7e-57 185.2 In-house 6-233 (235) alignment 
Range on Protein: 823-1073
Range on HMM: 6-233/235.0
GFADTIGR-RSTMEDESVIygtyrgkhDEDYFALFDGHGGNDAAKAASEELHRILAEK-LKLNHANPVKCLKESFLATHTLIGERGIR------CGTTAV
|.|  ||| |...||  ..        .  .||..|||||  |.. ||| |...|.|  |.|.. .....|...|||... . |....      .|||||
gaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTav

VALFIGKKGYIANVGDSRAVLCRDGIAVRVSLDHKPNLPKEEERIRALGGNVvtttssagvvtsRVNGQLAVSRALGDSFLNpfvtsePDIHgpinLETH
|||..|.| |.||||||||.|.||| .|... ||.|. . | .||...|| |            ||.|.||..|||||..|.      ||..      . 
valldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav............rvpgrlaltralGdlllk......pdvt....vlel

IKNQFMIIACDGIWDVISDEEAVSIAAPiADPEKACIKLRDQAFSRGSTDNISVIVIRF
 .. |...|.||.|||.||||.|.. .   |.|.|. .| ..|..||..|||.|.|.|.
epgdflllasDGlwdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvvvvrl
PP2C Protein phosphatase 2C 826-1066 6.1e-65 212.3 Pfam-A 7-255 (255) alignment 
Range on Protein: 826-1066
Range on HMM: 7-255/255.0
DTIGRRSTMEDESVIYGTY---RGKHDEDYFALFDGHGGNDAAKAASEELHRILAEKLKLNHA-NPVKCLKESFLA-THTLIGE---R--GIRCGTTAVV
.. |.|..|||. ... .    .|| .. .|| |||||| .||| |.| |. ||.|. ... . .  |.|..|||| |   .     .   ...|.||||
elqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGstavv

ALFIGKKGYIANVGDSRAVLCRDGIAV-RVSLDHKPNLPKEEERIRALGGNVVTttssagvvTSRVNGQLAVSRALGDSFLNP----FVTSEPDIHgPIN
||. ||| |.||||||||||||.. |. ... ||||. ..| |||...|| |            ||||.||||||||| .| |    .|..|||..  ..
alirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn........ngrvngsLavsRalGdfelkpkeeqlvsaePdvt.svk

LETHikNQFMIIACDGIWDVISDEEAVSIAAPIAD----PEKACIKLRDQAFSRGSTDNI
|. .  ..|.|.|.||.|||.||.|||...    .    |..|. .|.|.| .|||.|||
ltee..defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 826-1066 6.1e-65 212.3 In-house 7-255 (255) alignment 
Range on Protein: 826-1066
Range on HMM: 7-255/255.0
DTIGRRSTMEDESVIYGTY---RGKHDEDYFALFDGHGGNDAAKAASEELHRILAEKLKLNHA-NPVKCLKESFLA-THTLIGE---R--GIRCGTTAVV
.. |.|..|||. ... .    .|| .. .|| |||||| .||| |.| |. ||.|. ... . .  |.|..|||| |   .     .   ...|.||||
elqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGstavv

ALFIGKKGYIANVGDSRAVLCRDGIAV-RVSLDHKPNLPKEEERIRALGGNVVTttssagvvTSRVNGQLAVSRALGDSFLNP----FVTSEPDIHgPIN
||. ||| |.||||||||||||.. |. ... ||||. ..| |||...|| |            ||||.||||||||| .| |    .|..|||..  ..
alirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn........ngrvngsLavsRalGdfelkpkeeqlvsaePdvt.svk

LETHikNQFMIIACDGIWDVISDEEAVSIAAPIAD----PEKACIKLRDQAFSRGSTDNI
|. .  ..|.|.|.||.|||.||.|||...    .    |..|. .|.|.| .|||.|||
ltee..defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 826-1066 3.6e-64 209.7 In-house 7-259 (259) alignment 
Range on Protein: 826-1066
Range on HMM: 7-259/259.0
DTIGRRSTMEDESVIYGTYR---GKHDEDYFALFDGHGGNDAAKAASEELHRILAEKLKLNHA-NPVKCLKESFLATHTLIGER-------GIRCGTTAV
 . |.|..|||  ... . .   || .. .|| ||||||  ||| |.| |. ||.|.  ..   .. |.|..|||| .| .  .        ...|.|||
afqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsGstAv

VALFIGKKGYIANVGDSRAVLCRDGIAV-RVSLDHKPNLPKEEERIRALGGNVVTTtssagvVTSRVNGQLAVSRALGDSFLNP------FVTSEPDIHg
|||..|.| |.||||||||||||.| || ... ||||....| |||...||.| .         .||||.||||||.|| .| |       |..||||. 
valitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnv......gngrvngvlavsRafGdfelkpketeeqlvsaePdis.

piNLETHIKNQFMIIACDGIWDVISDEEAVSIAAPIAD---PEKACIKLRDQAFSRGSTDNI
    .   ...|.|.|.||.|||.||.|||...    .   |..|. ||.| | .|||.|||
..stkideedefliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
subfamily_PPM1L_pd Subfamily PPM1L 827-1073 2.8e-46 150.9 In-house 12-266 (269) alignment 
Range on Protein: 827-1073
Range on HMM: 12-266/269.0
TIGRRSTMEDESVIYGTYRGKHDEDYFALFDGHGGNDAAKAASEELHRILAEKL---KLNHA-----NPVKCLKESFLATHTLIGERGI----RCGTTAV
  |||  |||   |    . | .|..||.||||||. ||. | . | . . .||   . ..      |  | |..  |.  . . |.        ||||.
vlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGttal

VALFIGKKGYIANVGDSRAVLC-RDGIAVRVSLDHKPNLPKEEERIRALGGNVvtttSSAGVvtSRVNGQLAVSRALGDSFLN--PFVTSEPDIHGpINL
.||  ...  .||||||| ||. ..|.|. .| ||||. .||  ||.  || .    .  ||   ||.| ||.||||||  |    .| ..|||   ..|
ialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfi....afrGv..wrvaGvlatsralGdyplkdknlviadpdilt.fdl

ETHiKNQFMIIACDGIWDVISDEEAVSIA-APIADPEKACIKLRDQAFSRGSTDNISVIVIRF
. | | .|.|.|.||.|| .|.||||  .   . .|.     |  ..| |||.|||.|.|...
ddh.kpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvkl
PPM_PTC7_SpoIIE 827-1040 1e-32 106.8 In-house 8-205 (230) alignment 
Range on Protein: 827-1040
Range on HMM: 8-205/230.0
TIGRRSTMEDESVIYGTYR---GKHDEDYFALFDGHGGNDaaKAASEELHRILAEKLkLNHA-NPVKCLKESFLATHTLIGERGIRCGTTAVVALFIGKK
. |.|..|||  ... . .   |..   ... .|||||    ..|...|. .|.|    . . .| ..|....|| .. . .. . .|.||||||. . .
aqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadledepsssgaTavvalidpst

--GYIANVGDSRAVLCRD-GIavrvsldhkpnlpkEEERIrALGGNV-VTT--TssagvvtsRVNGQLAVSRALGDSFLNP---FVTSEPDihgPINLET
   |.||.|||...|.|| |               |.||| ..|| . .    .        ||.|.||||.| || .| .    |..|||    .  |.
gklyvanaGdsppllvrddgg..............ereri.vagglpslGilpg........rvfgvlavslapGdllllytDGvveaepd...tsdgel

HIKNQFMIIACDGIWDVISDEEAVSIA
  |..|.|.|.||.||| |..|.|...
fgkdeflilasdglwdvlspqelvdlv
subfamily_PPM1D_pd Subfamily PPM1D 828-1042 1.3e-31 102.9 In-house 10-263 (309) alignment 
Range on Protein: 828-1042
Range on HMM: 10-263/309.0
IGRRSTMEDESVIYGTYRGK---HDEDYFALFDGHGGNDAAKAASEELHRILAEKLKLNHANP---VKCLKESFLATHTLIGER---------G--IRCG
 | |  |||  .|.   . .    .  ..|.||||||..||| |.|.|   . .. |.   .|   .. ..|.|||||. . ..         |     |
qGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllstaG

TTAVVALFIGKKGYIANVGDSRAVLCRDGI------AVRVSLDHKPNLPKEEERIRALGGNVVTTTSSAGVVTSR----VNGQ--------LAVSRALGD
||| | .. ..| |.|.||||..||  .        |  .  ||||. |.|.|||. |||.| . .    || .|     ||.        |||.|.|||
ttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaRslGD

-----SFLNPFVTS-EPDIHGpiNLETHIKNQFMIIACDGIWDVISDEEAVSIAAP
     .. . || | |||.       .  ...|.|.| ||.|.|.. |.|||.   
lWsynaksgefvvsPePdvkv..rtldpneekfiilasDGlwnvltpedavsvvek
subfamily_PPM1E_pd Subfamily PPM1E 829-1075 7e-58 188.9 In-house 13-264 (265) alignment 
Range on Protein: 829-1075
Range on HMM: 13-264/265.0
GRRSTMEDESVIYGT------YRGKHDEDYFALFDGHGGNDAAKAASEELHRILAEKLKLNHaNPVKCLKESFLATHTLIGER----GIRCGTTAVVALF
..| .|||  |..         ...... .|| |||||| .||| |...||. |... ||.. .|.. |||.| .| . . ..    ....|.||||.| 
nkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklke.dpaealkeafkltDerflqkaereklksGstavvvli

IGKKGYIANVGDSRAVLCRDGIAVRVSLDHKPNLPKEEERIRALGGNVVTTtssaGvvTSRVNGQLAVSRALGDSFLNPFVTSEPDIHgpiNLETHIKNQ
 ... |.| .|||.|.|.|.| ||..   |||. ..|..|| ..|| || .    |  . ||||.|.||||.||  |.|.|..|.|.    ..| . ...
ekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvi....g..awRvnGvLsvsRaiGDvklkpyvsgeadva...eveldgsee

FMIIACDGIWDVISDEEAV-SIAAPIADPE----KACIKLRDQAFSRGSTDNISVIVIRFPP
..|.||||.|||. .||.|  . . .||..    ..  .| ..| ..||.|||.|.|. ..|
ylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfldp
subfamily_PP2D1_pd Subfamily PP2D1 831-882 1.2e-09 30.4 In-house 14-65 (492) alignment 
Range on Protein: 831-882
Range on HMM: 14-65/492.0
RSTMEDESVIYGTYRGKHDEDYFALFDGHGGNDAAKAASEELHRILAEKLKL
.|.|||. ..   .  . .. .|...||. |. ||. |..|||..|.|.|. 
KskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelek
PP2C_SIG_SM00331 840-1073 1e-12 41.1 In-house 20-217 (217) alignment 
Range on Protein: 840-1073
Range on HMM: 20-217/217.0
IYGTYRGKHDEDYFALFDGHGGNDAAKAASEELHRILAEKLKLNhANPVKCLKESFLATHTLigERGIRCGTTAVVAL--FIGKKGYIANVGDSRAVLCR
.|...  . ..  ....||.|.  || |||..|.  | | |. .  .... ||.   | . .  .   . ..|...||  | ..| ..||.|||| .| |
yydvvklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllr

DGIAVRVSLDhkpnlpkeeeriralggnvvtttssagvvtsrvngqlavS-----------RalgdsflnpfvtsepdihgP-INLETHIKNQFMIIACD
||  |    |                                                   .                   . |   .  |  ..... |
dgklveilkd.......................................vegaplGlepevs...................vdirelelekgdllllytD

GIWDVISDEE--AVSIAAPIADPEKACIKLRDQ-------AFSRGS--TDNISVIVIRF
|.... |...     .   ..|  . . .  .|       ....||   |.|.|.|...
GltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvvkv
subfamily_PPM1H_pd Subfamily PPM1H 849-881 1.2e-07 23.9 In-house 61-93 (404) alignment 
Range on Protein: 849-881
Range on HMM: 61-93/404.0
DEDYFALFDGHGGNDAAKAASEELHRILAEKLK
.  ||.|||||.|. || .||. ||..| |||.
playfglfDGhaGsgaalvaskllhkhlkekle
subfamily_KAPP-like_pd Subfamily KAPP-like 851-1072 4e-30 97.7 In-house 35-265 (266) alignment 
Range on Protein: 851-1072
Range on HMM: 35-265/266.0
DYFALFDGHGGNDAAKAASEELHRILAEKLKL--------NHANPVKCLKESFLATHTLIGERGIRcGTTAVVALF--IGKKGYIA--NVGDSRAVLCRD
  ||.|||| |. ||.||.. . ..| ..||         |  .  | |...|    . . .     |.|| .||    |.. |.   ||||| | |.| 
alfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeye.GatatlalvwsdGqqrylqvanvGdssaflsrG

GIAVRVSLDHKPNLPKEEERIRALGgnvVTTTSSagvvTSRVNGqLAVSRALGDSFL---NPFVTSEPDIHGPINLEThiKNQFMIIACDGIWDVISDEE
  .. .| ||| . |.|  ||.  |   .| . .     .|.|| ||||||||| |.   |  ..||| .  .| |    ...|.|.| ||.||||| ..
neslelskdhkakdpeekqrikddG...itlsdn....qtrinG.lavsralGdhfikelniGlisepyvsnrilltp..fdkflivasdGlwdvisGkd

AVSIAAPIADP----EKACIKLRDQA-FSRGSTDNISVIVIR
|. .   . |     .| .  | . |  |  . ||.||||..
aiekvkslydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 853-1005 1.1e-20 67.3 In-house 24-196 (292) alignment 
Range on Protein: 853-1005
Range on HMM: 24-196/292.0
FALFDGHG--GNDAAKAASEELHRILAEKLKLNHANPVKCLKEsFLAT----HTLIGERGIRCGTTAVVALFIGK-KGYIANVGDSRAVLCR-----DGI
 |..||||  |.  |. | ..|   | |  . . . .   |.   | .    . |  . . ...|..| |      . ..||||||||.| |     |  
aavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllr.ildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsdye

AVRVSLDHKPNLPKEEERIRALGGNVV-TTTSSAGV-VTSRV------NGQLAVSRALGDSFLN-PFVTSEPDI
 . .| ||||. | |..||.. || |  |     |   |.||      .|.||.||||||  |    | .||..
liPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePel
subfamily_PPM1G_pd Subfamily PPM1G 904-1060 2.4e-34 112.2 In-house 291-451 (473) alignment 
Range on Protein: 904-1060
Range on HMM: 291-451/473.0
ERGIRCGTTAVVALFIGKKGYIANVGDSRAVLCRDGIAVRVSLDHKPNLPKEEERIRALGGNVVTttssagvvTSRVNGQLAVSRALGDSFL--------
| |   ||||||||  .|| ..||.||||.||.|.| |. .||||||. ..| |||.. ||.| .          |||| | .|||||| .         
epGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvde........dgRvnGGLnlsRAlGDhaYkkneeLpl

-NPFVTSEPDIHGpinLETHIKNQFMIIACDGIWDVISDEEAVS-IAAPIADPE-----KACIKLRDQAFSR
 .  ..  |||.    |.   ...|...||||||.|.. .| |  . | ... |     ... .| |.... 
keqmisAlPDikv...ltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclap
subfamily_TAB1_pd Subfamily TAB1 904-1029 1.7e-14 46.4 In-house 124-258 (333) alignment 
Range on Protein: 904-1029
Range on HMM: 124-258/333.0
ERGIRCGTTAVVALFIGKKGYIANVGDSRAVLCR---DGIAVRVSLDHKPNLPKEEERIRALGGNVVTTTSS---AGVVTSRVNGQLAVSRALGDSFL--
|. |. |||||||| . .| |.||||||||.|..       . .| ||. . ..| .|.. || .. .  .    ..  . |  |.. |     |  .  
eeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdils

---NPFVTSEPDIHGPINLETHIknQFMIIACDGIWD
   .. | .||||.|. ...     .|...  ||.  
sakgePviaePdiqgaypiddit..yflvlmSdGvyk
subfamily_PPM1H_pd Subfamily PPM1H 907-962 2.8e-11 35.8 In-house 160-213 (404) alignment 
Range on Protein: 907-962
Range on HMM: 160-213/404.0
IRCGTTAVVALFIGKKGYIANVGDSRAVLCRDGIAVRVSLDHKPNlpKEEERIRAL
|. | ||.|||.. .| |.|| |||||.|.| .  . .| |. |.   | .|.. |
ikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPe..teRqRlqel
subfamily_PDP_pd Subfamily PDP 909-993 7.5e-08 24.9 In-house 152-238 (398) alignment 
Range on Protein: 909-993
Range on HMM: 152-238/398.0
CGTTAVVALFIGKKGYIANVGDSRAVLCR---DG--IAVRVSLDHKPNLPKEEERIRALGGNvvtTTSSAGVVTSRVNGQLAVSRALGDS
 |..|..||  |.. ..||.||.||||..   .|   ||..| |.  . ..| |||..   .     | . . ..|. |.|. .|| || 
sGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPg...eesktvirngRlLgeLqPlRAFGdv
subfamily_PP2D1_pd Subfamily PP2D1 923-1041 2.3e-21 69.1 In-house 190-303 (492) alignment 
Range on Protein: 923-1041
Range on HMM: 190-303/492.0
GYIANVGDSRAVLCRDGIAVRVSLDHKPNLPKEEERIRALGGNVVTTTSsagvvTSRVNGQLAVSRAL---GDSFLNPFVTSEPDIHGpINLETHikNQF
 ||||.|. .|||||.| |...  .| |. .|| .|..  |. || .       ...|||.| . | |   ||  |.  |  || ..  ..|. .  .||
lyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvksek.....nglvnGildttRGLGnyGdpkLkksvipePktts.vkldea..aqf

MIIACDGIWDVISDEEAVSIAA
...|  |.|.|.|.|| .|.. 
lvlAsnGlWevlseeevlsLvk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 925-1072 2.3e-22 72.2 In-house 130-275 (276) alignment 
Range on Protein: 925-1072
Range on HMM: 130-275/276.0
IANVGDSRAVLCRDGIAVRVSLDHKPNLPKEEERIRALGgnvVTTTSSagvvTSRVNGqLAVSRALGDSFL---NPFVTSEPDIHGPINLEThiKNQFMI
.|||||| | |.|   .. .| ||| . |.| .||.  |   .| . .     .|.|| ||||||||| |.   |  ..||| .  .| |    ...|.|
vanvGdssaflsrGneslelskdhkatdpeekqrikddG...itlsdn....qtrinG.lavsralGdhfikelniGlisepyvsnrilltp..fdkfli

IACDGIWDVISDEEAVSIAAPIADP----EKACIKLRDQA-FSRGSTDNISVIVIR
.| ||.||||| ..|. .   . |     .| .  | . |  |  . ||.||||..
vasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk
Subfamily Dicty-PPM1L-like 925-964 8.2e-06 17.8 In-house 231-270 (305) alignment 
Range on Protein: 925-964
Range on HMM: 231-270/305.0
IANVGDSRAVLCRDGIAVRVSLDHKPNLPKEEERIRALGG
.|. .|.. ||..||..  .| ..... .||  |..  ..
vakanDqflvlatdGlwevlsyqdvveevkellrdkssqk
Subfamily Dicty-PPM1L-like 977-1073 6.3e-09 28.1 In-house 198-303 (305) alignment 
Range on Protein: 977-1073
Range on HMM: 198-303/305.0
TSRVNGQLAVSRALGDSFLNPFVTsePDIHGPINLETHIKNQFMIIACDGIWDVISDEEAVSIAAPIAD-----------PEKACIKLRDQAFSRGSTDN
. .||. | .||  ||  |. .|   |.   |.   ..  .||...| ||.|.|.| .. |     .             ..        .| .||| ||
ellvnrllkksrskGdknlkelvi..PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgDn

ISVIVIRF
| ...| .
itlviikl
subfamily_PPM1H_pd Subfamily PPM1H 979-1040 6.9e-07 21.4 In-house 276-347 (404) alignment 
Range on Protein: 979-1040
Range on HMM: 276-347/404.0
RVNGQLAVSRALGDS---------FLNPFVTSEPDIHG-PINLETHIKNQFMIIACDGIWDVISDEEAVSIA
|. . ..|.| |||          .. ||....|...   ..   ..... .|.| ||.|||.|.||.  | 
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeiv
subfamily_PDP_pd Subfamily PDP 997-1042 1.5e-07 23.9 In-house 268-310 (398) alignment 
Range on Protein: 997-1042
Range on HMM: 268-310/398.0
PFVTSEPDIHgpiNLETHIKNQFMIIACDGIWDVISDEEAVSIAAP
|..|.||..    . . . ...|...| ||.||..|.||.||.   
PYltaePevt...shklrendkFLvlatDGLwdllsneevvslVge
PPM_PTC7_SpoIIE_motif 1019-1073 5.5e-08 26.4 In-house 14-80 (81) alignment 
Range on Protein: 1019-1073
Range on HMM: 14-80/81.0
FMIIACDGIW-------DVISDEEAVSIAA--PIADPEKACIKLRDQAFSRG---STDNISVIVIRF
 .....||..       .....||....|.  .  ...... ||.|.. ..|   ..|.|...|.|.
vllLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevlengsgereDDitllvlrv
PPM_PTC7_motif 1021-1066 2.3e-14 46.6 In-house 1-51 (51) alignment 
Range on Protein: 1021-1066
Range on HMM: 1-51/51.0
IIACDGIWDVISDEEAVSIAAPIAD-----PEKACIKLRDQAFSRGSTDNI
|.|.||.|||.||.|||...    .     |..|. ||.|.| .|||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni