Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PPM1G_pd | Subfamily PPM1G | 142-241 | 9.7e-11 | 34.3 | In-house | 7-103 (473) | alignment | ||
Range on Protein: 142-241
Range on HMM: 7-103/473.0
TEPSSKTRSVRDFGVSFEKNARYRRTMEDEHVIIDCFggDANQGYFAIYDGHGGRGAVEFTAKTLHvNLLDEINKSPEGDILELFRNSYLLTDKQMNESE
.| .|...| ... ... .| .|| | | . | . ||.||||||. ...||.| .|| . . |||. . .....| |..... |
vekesedesneelsygasamqGwrvsqEDahncitdl..dedtslfavyDGHGGkevakyvakklp.dllkaqkgykegdvekaleeaflalDeklkaee
|
|||||||||
subfamily_PPM1A_pd | Subfamily PPM1A | 147-403 | 3.7e-83 | 272.1 | In-house | 8-280 (282) | alignment | ||
Range on Protein: 147-403
Range on HMM: 8-280/282.0
KTRSVRdFGVSFEKNarYRRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLD-------EINKSPEGDILELFRNSYLLTDKQMNE
.....| .||| .. .|..|||.|... ..|. .....||..|||.|. ......|.|. |.|. ....|.. ...| .|...| .|....|
egnglr.ygvssmqg..wrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeaire
SEIQFS-----GTTSITALIRknpvdgEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMKD----
.. . . |.|..|.|.. ||.|..||.||.|||.|.|. |..|..|||.|.|.| |||..|||.|...|||| |||.|.|||...|.
lstdlktadksGsTavtvlvs......ekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeek
-----HVIGDPYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNE----TEAQKMSDKLLLHALKKGSTDNISIIVVIL
.|...|. .||. .. ...|.|||||.|||.||...|.|. .. .|.......|. .||.|||.||.|..||..
kaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
|
|||||||||
PP2Cc_SM00332 | 147-401 | 1.2e-65 | 214.7 | In-house | 3-274 (274) | alignment | |||
Range on Protein: 147-401
Range on HMM: 3-274/274.0
KTRSVRDFGVSFEKNARYRRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPE---GDILELFRNSYLLTDKQMNESEI-
...|. .. .. .. .|..||| ||.. .. .. ..|...||||| ...|..| |. .| .|..| . |. |. ....| ||....|.|
esgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqs
-----QFSGTTSITALIRKNPvdgekyLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMK-------D
. ||.| ..||..|. |||||.|| |||.| |. | .||.|||..|..|.||| .|||.| .||||| |||.|..||| .|
kelenalsGstavvallkked......lyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknkklkep
HVIGDPYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNET------EAQKMSDKLLLHALKK-GSTDNISIIVV
... .| ..|.| . ||||.|||||| |.|..||.. . ..|.....| .|... ||.|||...||
yitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
|
|||||||||
0034914 | PP2C-like | 151-403 | 1.8e-68 | 223.4 | In-house | 18-290 (295) | alignment | ||
Range on Protein: 151-403
Range on HMM: 18-290/295.0
VRDFGVSFEKNARYRRTMEDEHVIIDCFGG-DANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDE------INKSPEGDILELFRNSYLLTDKQMNESEIQ
. |.. . .|...|| .... .. . ....|...||||| | |. ...|. .||.. .. ... ||.| .|...| .|... | ..
llllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelall
-----FSGTTSITALIRKNpvdgekYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMK---------
.|||| ..||||.| .|||||.|| |||...|.....|..||| ....|..|| .|||.| .|||||.|||||.|||...|
rpelagsGtTavvalirgn......klyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllle
DHVIGDPYKRSIKLD-SGHTHLILACDGLWDVTSDQDAVDLILN----ETEAQKMSDKLLLHALKKGSTDNISIIVVIL
.|. |. ....|. . . |.||.|||||| |....||.. . .........|. .||..||.|||...|| |
plvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrl
|
|||||||||
subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 153-402 | 1.7e-66 | 217.1 | In-house | 5-252 (255) | alignment | ||
Range on Protein: 153-402
Range on HMM: 5-252/255.0
DFGVSFEKNARYRRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPEgDILELFRNSYLLTDKQMNESEiQFSGTTSITA
| |.| . | ||||| || | .. .. |.|..|||||| | .|....|. | . .. . . .. ....| .. |..| .| |||....
rfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnna.nPvkslkkaykeistqiserp.kfiGttaasv
LIRKNpvdgekYLYVANAGDARAVVC-HNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNG----RVNGILAVTRSLGDHSMKDHVIGDPYKR-SIKLDSG
|| .. . |.|| ||.|.|.| .. .|.|||.||| |...| ||| ..||.| .. |||| |||.|.||| .. .|. ||. |..
liied......kvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskk
HTHLILACDGLWDVTSDQDAVDLILNETEAQKMSDKLLLHALKKGSTDNISIIVVI
. .|||||||.||. ||..||..... ....| . || .| ..|||||||.||.
dkflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisvivik
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 153-216 | 2.6e-17 | 55.7 | In-house | 2-65 (492) | alignment | ||
Range on Protein: 153-216
Range on HMM: 2-65/492.0
DFGVSFEKNARYRRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINK
.|. .||.|.. .|||.... | || |.|...|.||||. |. | | .||.||. ||.|..|
avGiCedknsrWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelek
|
|||||||||
PP2C | Protein phosphatase 2C | 155-396 | 5.7e-68 | 222.2 | Pfam-A | 2-255 (255) | alignment | ||
Range on Protein: 155-396
Range on HMM: 2-255/255.0
GVSFEKNARYRRTMEDEHVIID---CFGGDANQGYFAIYDGHGGRGAVEFTAKTLHvNLLDEINKSPEG-DILELFRNSYLL-TDKQMNE---S-EIQFS
.|..... ..|..|||.|.... . .|. . ..||..|||||| | ......|. ..|.| . .|. . ...|.|.| ||.... . | . |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfladtdeelksskantepsks
GTTSITALIRKNPvdgekyLYVANAGDARAVVCHNKVAE-RLSYDHKGSDPEEVKRIDAAGGFVC-NGRVNGILAVTRSLGDHSMKD----HVIGDPYKR
|.|...||||.. |||||.||.|||.| .. |. .|..||| ||..|..|| .|||.| |||||| |||.|.|||. .|. .|. .|. .
Gstavvalirgkk......lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvt
SIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETE----AQKMSDKLLLHALKKGSTDNI
|.||.. . ||||.|||||| |||.||||. .| . .......|. .|...||.|||
svklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
|
|||||||||
PP2C | Protein phosphatase 2C | 155-396 | 5.7e-68 | 222.2 | In-house | 2-255 (255) | alignment | ||
Range on Protein: 155-396
Range on HMM: 2-255/255.0
GVSFEKNARYRRTMEDEHVIID---CFGGDANQGYFAIYDGHGGRGAVEFTAKTLHvNLLDEINKSPEG-DILELFRNSYLL-TDKQMNE---S-EIQFS
.|..... ..|..|||.|.... . .|. . ..||..|||||| | ......|. ..|.| . .|. . ...|.|.| ||.... . | . |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfladtdeelksskantepsks
GTTSITALIRKNPvdgekyLYVANAGDARAVVCHNKVAE-RLSYDHKGSDPEEVKRIDAAGGFVC-NGRVNGILAVTRSLGDHSMKD----HVIGDPYKR
|.|...||||.. |||||.||.|||.| .. |. .|..||| ||..|..|| .|||.| |||||| |||.|.|||. .|. .|. .|. .
Gstavvalirgkk......lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvt
SIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETE----AQKMSDKLLLHALKKGSTDNI
|.||.. . ||||.|||||| |||.||||. .| . .......|. .|...||.|||
svklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
|
|||||||||
PPM_PTC7 | 156-396 | 7.3e-68 | 221.8 | In-house | 3-259 (259) | alignment | |||
Range on Protein: 156-396
Range on HMM: 3-259/259.0
VSFEKNARYRRTMEDEHVIID---CFGGDANQGYFAIYDGHGGRGAVEFTAKTLHvNLLDEINKSPEG-DILELFRNSYLL--TDKQMNE---S-EIQFS
...... ..|..||| |.. . . .|. . ..||..|||||| | ......|. . |.| .|. . . .|.|.| ||. .. . | . |
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehle.eilkerksfeeleklekalrksflaldtdeelksseantepsts
GTTSITALIRKNPvdgekyLYVANAGDARAVVCHNKVAE-RLSYDHKGSDPEEVKRIDAAGGFVC---NGRVNGILAVTRSLGDHSMKD------HVIGD
|.| ..|||... |||||.||.|||.| .. | .|..||| |...|..|| .|||.| |||||| |||.|..||. .|. .|. .
GstAvvalitgsk......lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsae
PYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEA---QKMSDKLLLHALKKGSTDNI
|. |.|.|. . .||||.|||||| |||.||||. .| .. .. ..||. .|...||.|||
PdisstkideedefliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
|
|||||||||
PPM_PTC7_SpoIIE | 156-395 | 2.9e-35 | 115.2 | In-house | 3-229 (230) | alignment | |||
Range on Protein: 156-395
Range on HMM: 3-229/230.0
VSFEKNARYRRTMEDEHVIID---CFGGDANQGYFAIYDGHGGRGavEFTAKTLHvNLLDEINkSPEGD-ILELFRNSYLLTDKQMNESeIQFSGTTSIT
... .. ..|..||| |.. . . .|. .....|||||| .....|. ..|.|. .... |..|...|. ....... . ||.| .
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllr.talrela.faglekpeeilrrlnlalaadlede.psssgaTavv
ALirknpVDGEK-YLYVANAGDARAVVCHNKVAerlsydhkgsdpeEVKRIdAAGGFV-C---NGRVNGILAVTRSLGDHSMKD---HVIGDPYkRSIKL
|| .|... |||||||| ........ |..|| .|||.. .|||.| |||... || ... | |. | ..
al.....idpstgklyvanaGdsppllvrddgg.............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.tsdge
DSG-HTHLILACDGLWDVTSDQDAVDLILNETEAQkMSDKLLLHALKKGSTDN
. | . .||||.|||||| |.|..|||...| |. ....|| ... .....
lfgkdeflilasdglwdvlspqelvdlvrdelekp.aaeglleDDitllvvrv
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 157-310 | 4e-18 | 58.6 | In-house | 5-173 (309) | alignment | ||
Range on Protein: 157-310
Range on HMM: 5-173/309.0
SFEKNARYRRTMEDEHVIIDCF---GGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLD--EINKSPEGDILELFRNSYLLTDKQMNESEIQ--------
. | .. |. ||| .| . . .. ..|..|||||. | .|. . | .. . .. |.. |.|| |...| | ..|... .
tseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgl
--FSGTTSITALIRKNpvdgekYLYVANAGDARAVVCHNKV------AERLSYDHKGSDPEEVKRIDAAGGFVCN
.||| . .||.. ||||. ||...|. .. |. | ||| ..|||..||. .|| | .
lstaGttasvviirre......klyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
|
|||||||||
subfamily_PPM1E_pd | Subfamily PPM1E | 162-403 | 1.7e-56 | 184.4 | In-house | 12-262 (265) | alignment | ||
Range on Protein: 162-403
Range on HMM: 12-262/265.0
ARYRRTMEDEHVIIDCF----G--GDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPEGDilELFRNSYLLTDKQMNES---EIQFSGTTSITA
||.||| ||... . . .. .. .||..||||| | ...|. || .| .. . . | ..... |||... . | ||.|....
knkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa..ealkeafkltDerflqkaereklksGstavvv
LIRKNPvdgekyLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCN---GRVNGILAVTRSLGDHSMKDHVIGDPYKRSIKLDSGHTH
||.|. |||| ||..|..... | .| || ....| |||..|||.|.. ||||.|.|.|..|| . |..|.|.. ...||. .
liekdq......lyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgseey
LILACDGLWDVTSDQDAVDLILNET-----EAQKMSDKLLLHALKKGSTDNISIIVVIL
||||||||||| ....|.|. . . .... .|. .| ..||.|||...||.|
lilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
|
|||||||||
0049733 | PP2C-like | 163-402 | 3.4e-53 | 173.3 | In-house | 13-232 (235) | alignment | ||
Range on Protein: 163-402
Range on HMM: 13-232/235.0
RYRRTMEDEHVIidcfggdaNQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPEGDILELFRNSYLLTDKQMNESEIQF-----SGTTSITALIRkn
|.|...|| ... ....||..||||| | |. ...|. .||... . .. |..|..|...| ..... | .. .||| ..||..
rvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTavvalld..
pvdgEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVcngRVNGILAVTRSLGDHSMKdhvigdPYKRSIKLDSGHtHLILACDGL
...|||||.|| ||...... ...|..||. ....|..|| .|||.| ||.|.||.||.|||. .| |. ....|..|. |.||.|||
....ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk......pdvtvlelepgd.flllasDGl
WDVTSDQDAVDLILNeTEAQKMSDKLLLHALKKGSTDNISIIVVI
||| ||...|||. . ...... ..|. .||..|..|||...||
wdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvvvvr
|
|||||||||
subfamily_PPM1G2_pd | Subfamily PPM1G2 | 163-403 | 6.7e-52 | 169.2 | In-house | 28-286 (287) | alignment | ||
Range on Protein: 163-403
Range on HMM: 28-286/287.0
RYRRTMEDEHVI-IDC--FGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSpEGDILELFRNSYLLTDKQMNES---EIQFSGTTSITALIRK
||..||| |.. . | . .||..|||||. . ....| |. . . . || . .......| ||... . . . .|.|....||..
GyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk.egaleqilkdafletDeellkdeklkdesaGstavvvlike
NPvdgekyLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMKDHVIGDPYKR---------SIKLDSGH
. ||||||||.|||.... .. ||.||| .. .| ||| |||||| .|||| ||. |.|||.. |..| | . |||. .
ek......lyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldedd
THLILACDGLWDVTSDQDAVDLI----LNETEAQKMSDKLLLHALKKGST------DNISIIVVIL
|.|||||.||| .... |||. .... ......|| ..|.. | ||.....|.|
eflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
|
|||||||||
subfamily_ILKAP_pd | Subfamily ILKAP | 164-401 | 4.1e-40 | 130.8 | In-house | 15-290 (293) | alignment | ||
Range on Protein: 164-401
Range on HMM: 15-290/293.0
YRRTMEDEHVIIDCFGGD---A-----NQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPE----GDILELFRNSYLLTDKQMNE----SEIQ-FSG
| .|.|.|||.. . . . . |.|..|||.|. | ||.|..|| ..|... || .| . .|. ||... . .. . |
ereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvWkdG
TTSITALIRKNpvdgekYLYVANAGDARAVVCHNKVAER------LSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMKDH-VIGDPYKR
.| .. |. | ||||| ||..||.. .| . . |. ||. . || |||. |||.| .|||.|.| |.||.|| | || | .
statvvlvldn......vlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlGvistPdvk
SIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEAQ--------------------KMSDKLLLHALKKGSTDNISIIVV
..|. ...|||||||.| | ...|. ||. |.. ...| .|.|.||.||.....|
kceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllv
|
|||||||||
subfamily_PPM1L_pd | Subfamily PPM1L | 165-402 | 4.5e-44 | 143.7 | In-house | 16-265 (269) | alignment | ||
Range on Protein: 165-402
Range on HMM: 16-265/269.0
RRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEI-----NKSPEG--DILELFRNSYLLTDKQMNES---EIQFSGTTSITALI
| ||| | . .... .||..||||| | ||. . | ...... .| . . .|. . | |... | . . .|||.. ||.
rprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGttalialv
RknpvdgEKYLYVANAGDARAVVCHNK-VAERLSYDHKGSDPEEVKRIDAAGGFVC-NG--RVNGILAVTRSLGDHSMKDH--VIGDPYKRSIKLDSGHT
. |. | ||| ||.| |.. .. | ||.||| ...| ||| ||||.. .| ||.|.||..|.|||. .||. || || ...|| .
q......esdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdlddhkp
H-LILACDGLWDVTSDQDAVDLILNETEAQKMSDK-LLLHALKKGSTDNISIIVVI
. ||||.||||| |...|| |... . .. | | |.. |.||.|||...||
eflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvk
|
|||||||||
subfamily_KAPP-like_pd | Subfamily KAPP-like | 168-403 | 5.3e-39 | 126.9 | In-house | 12-266 (266) | alignment | ||
Range on Protein: 168-403
Range on HMM: 12-266/266.0
MEDEHVIIDCFGGDA------NQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINK-------SPEGDILELFRNSYLLTDKQMNESEiqFSGTTSITALI
||| .. | .. . | . ||..||| |.|| . . | . .| . ... . | .|..|.. |..... | . |.|. ||.
medvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfe..yeGatatlalv
RKNPvdGEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNG--RVNGIlAVTRSLGDHSMKDHVI---GDPYK-RSIKLDSGHT
.. .|| ||| ||. | ... . ||.||| |||| .|| | .... |.||. ||.|.|||| .|. | ..|| | | .
wsdG..qqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdk
HLILACDGLWDVTSDQDAVDLILN----ETEAQKMSDKLLLHALKKG-STDNISIIVVIL
.||.| |||||| | .||.. . .. ..||.. || |.. . ||.|.||| |
flivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
|
|||||||||
subfamily_Dicty-PPM-1_pd | Subfamily Dicty-PPM-1 | 168-403 | 1.9e-36 | 118.3 | In-house | 11-276 (276) | alignment | ||
Range on Protein: 168-403
Range on HMM: 11-276/276.0
MEDEHVIIDCFGGDA------NQGYFAIYDGHGGRGAVEfTAKTLHVNLLDEINKS-------------PEGDILELFRNSYLLTDKQMNESEiqFSGTT
||| .. | .. . | . ||..||| |.|| . .|| | . | . || . | .|. . . |..... | . |.|
medvslaiyplldekdlsncsnialfavfdGhaGkGaad.aakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfe..yeGat
SITALIRKNP----VDGEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNG--RVNGIlAVTRSLGDHSMKDHVI---GDPYK-
. ||. .. . ..|| ||| ||. | ... . ||.||| .||||..|| | .... |.||. ||.|.|||| .|. | ..||
atlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvs
RSIKLDSGHTHLILACDGLWDVTSDQDAVDLILN----ETEAQKMSDKLLLHALKKG-STDNISIIVVIL
| | . .||.| |||||| | .||.. . .. ..||.. || |.. . ||.|.||| |
nrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 175-216 | 6.3e-06 | 18.2 | In-house | 53-94 (404) | alignment | ||
Range on Protein: 175-216
Range on HMM: 53-94/404.0
IDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINK
. . .. ||...|||.| || ..|.|| | .....
ekseeeklplayfglfDGhaGsgaalvaskllhkhlkekled
|
|||||||||
PP2C_SIG_SM00331 | 178-401 | 1e-11 | 37.8 | In-house | 24-215 (217) | alignment | |||
Range on Protein: 178-401
Range on HMM: 24-215/217.0
FGGDANQGYFAIYDGHG-GRGAVEFTAKTLHvnLLDEINKSPeGDILELFRNSYLLTDKQmneSEIQFSGTTSITALIrkNPVDGEkyLYVANAGDARAV
. .. . ... ||.| | | ........ .|.|. .. .. ..... . ... .| . ...| . ||. .. .|. |..||||| | .
vklnegrlllvvaDgmGkGlaAaaassqlrt..alrellseg.eelsqalkrlnraiyee...keekgmfaTlllaly..dfssgk..lsyanaGdsrpy
VCHnkvAERLSYDHKGsdpeevkridaaggfvcngrvngilAVTRSLG--DHSMkdhvigdPYKRSIKLDSGHThLILACDGLWDVTSDQ----DAVDLI
. . ..| ...| .. || .... .. |...|. | . |.|. |||... |.. . . .|
llr...dgklveilkd.........................vegaplGlepevs.......vdirelelekgdl.lllytDGltearsekgfaeerleei
LNET---EAQKMSD----KLLLHALKKGSTDNISIIVV
| .. |||.... .|| .| .. |.|...||
ledlvdseaqelaqkiveellelakgsngeDdiTvvvv
|
|||||||||
subfamily_PPM1K_pd | Subfamily PPM1K | 181-402 | 1.4e-38 | 125.5 | In-house | 28-257 (263) | alignment | ||
Range on Protein: 181-402
Range on HMM: 28-257/263.0
DANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEInkSPEGDILELFRNSYLLTDKQM--------NESEIQFSGTTSITALIRknpvDGEKyLYVANAGD
| . |.|..|||.| |..|. . |. | . | |. ....|... ||.. |.| . ||||. .|.| || . | .|. ||
dpellyvavfdGhaGsaaadfvhdklekilkrll..ekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllr....dGte.lvlaslGd
ARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVC-----NGRVNGILAVTRSLGDHSMKDH-VIGDPYKRSIKLDSG-HTHLILACDGLWDVTSDQD
.||..| | |..|. ||. . || .|| ||||.| . .||| ||.|||||| .| . || .| .|.|.| . . |.| ||. .| ..|.
srailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqe
AVDLILNETEAQKMSDKLLLHALKKGSTDNISIIVVI
||. .. .. .. | ||. || || ...||
lcdlvrlchdpeeaahalteqalqygsednatavvvp
|
|||||||||
subfamily_PHLPP_pd | Subfamily PHLPP | 186-402 | 3.6e-20 | 64.9 | In-house | 29-244 (246) | alignment | ||
Range on Protein: 186-402
Range on HMM: 29-244/246.0
YFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPEGdiLELFRNSYLLTDKQMNEsEIQFSGTTSITALIRKNPVDGEK--YLYVANAGDARAVVCHNKVA
. ..||. . . .... |..|..|. . | .| .| . ... | . . |.. . |||...|| | | ||. | ||.. |.
lyGlfdGdrneelssllqrlmkdvlkeevqkdkne..eeymkntllvaqrklGe.aGeklgsaallilirhdkvdPaksfsLevAsvGtlqavliRngkk
ERLSYDHKGSDPeEVKRIDAAGGFVC-NGRVNGILAVTRSLGDHSMKDHVIGDPYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEAQKMSDK
||| .. .. |.||| | ... ....||... || || .. |. .| |...| . ||. . ||.| | ..||. . .| .. |
lrlsksyviekd.elkrikeakaiitednkingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavrkeedplvaAkk
LLLHALKKGSTDNISIIVVI
| | | .|..|..||
lvdlaqsygaadsvsvlvvr
|
|||||||||
subfamily_Choan-PPM1K-like_pd | Subfamily Choan-PPM1K-like | 187-336 | 3.5e-18 | 59.1 | In-house | 24-194 (292) | alignment | ||
Range on Protein: 187-336
Range on HMM: 24-194/292.0
FAIYDGHG--GRGAVEFTAKTLHVNLLDEINksPEGDILELFRNSYLLTDKQMNESEIQFSGTTSITALIRKNPvDgEKYLYVANAGDARAVVCH-----
|..|||| |. .....|| |.||. . . .. | . . | . ..... |. .. .. . . | .. |..|| ||.||..
aavldGhGvnGdkvaqlaedtlevelleltr..qlqelsealllrildiaakldkltidaresattavvcarvr.d.dralilanvGdsrallgrclggs
NKVAERLSYDHKGSDPEEVKRIDAAGGFVC-----------NGRV------NGILAVTRSLGDH-SMKDHVIGDP
.. || ||| .||.| .|| .|||.| || .| ||..|.||| .. |. .|
dyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaeP
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 230-291 | 1.7e-07 | 23.4 | In-house | 144-202 (404) | alignment | ||
Range on Protein: 230-291
Range on HMM: 144-202/404.0
YLLTDKQMNESEIQFSGTTSITALIRknpVDGEKYLYVANAGDARAVVCHNKVAERLSYDHK
.| |.|... . .. . |||. . .. ||||||||.||...... || |.
flemDeqiarereayrikGGCtalva...lvllgklYvanaGDsRailvrkdeiiplsadft
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 234-329 | 4.1e-11 | 35.6 | In-house | 140-241 (398) | alignment | ||
Range on Protein: 234-329
Range on HMM: 140-241/398.0
DKQMNE-SEIQFSGTTSITALIRKNPvdgekyLYVANAGDARAVVCHNK-----VAERLSYDHKGSDPEEVKRIDAA------GGFVCNGRVNGILAVTR
.|...| . .||.....|||... |.|||.||.|||.. .. | .|| |. .. .|||.|| .. . |||. | |. .|
ekslreallvalsGacallaliegte......lhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlR
SLGDHSMK
|| |
AFGdvryK
|
|||||||||
subfamily_PPM1G_pd | Subfamily PPM1G | 237-380 | 1e-32 | 106.8 | In-house | 288-435 (473) | alignment | ||
Range on Protein: 237-380
Range on HMM: 288-435/473.0
MNESEIQFSGTTSITALIRKNpvdgekYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVC-NGRVNGILAVTRSLGDHSMKDHVIG-
.|.. . |||| . ||.... |.||||||.|.|...| .| ||.||| |..| .||..||| | .||||| | . | ||||. |
ekeepGedsGttAvvaLlkek......klivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLp
--------DPYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEAQKMS
| . .| . . |.|||||.|.| . |. || . .. . .. |
lkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees
|
|||||||||
subfamily_TAB1_pd | Subfamily TAB1 | 245-330 | 6.5e-12 | 37.9 | In-house | 129-214 (333) | alignment | ||
Range on Protein: 245-330
Range on HMM: 129-214/333.0
SGTTSITALIRKNpvdgekYLYVANAGDARAVVCH---NKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGI---LAVTRSLGDHSMKD
||| . ||| | |||||.||.||.... .. . || ||. ..|..|. | . . . |.. |||.||...|
gGttAvvalifnn......kLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkk
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 245-306 | 9.8e-07 | 20.9 | In-house | 211-270 (305) | alignment | ||
Range on Protein: 245-306
Range on HMM: 211-270/305.0
SGTTSITALIRknPVDGEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGG
| ... |. | . .. | ||.|.| . |.. . ..| |||... ...|. |. ..
kGdknlkelvi..PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqk
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 264-372 | 7.7e-25 | 80.5 | In-house | 189-304 (492) | alignment | ||
Range on Protein: 264-372
Range on HMM: 189-304/492.0
YLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVC----NGRVNGILAVTRSLG---DHSMKDHVIGDPYKRSIKLDSGHTHLILACDG
||.||||. .||.|.. .| .| .| ...| .|. ||. | ||.||||| .|| || | .| || .|. .|.||| |.|| |
vlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnG
LWDVTSDQDAVDLILN
||.| |... . |. .
lWevlseeevlsLvkq
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 300-402 | 3.2e-10 | 32.3 | In-house | 185-302 (305) | alignment | ||
Range on Protein: 300-402
Range on HMM: 185-302/305.0
RIDAAGGFVCN-G--RVNGILAVTRSLGDHSMKDHVIGDPYKRSIKL-DSGHTHLILACDGLWDVTSDQDAVDLIL---NETEAQK--------MSDKLL
||. ... . | | .||..| . || || ..| || .. . . ... |.|| ||||.| | || |. .. ... || .|
rieslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviv
LHALKKGSTDNISIIVVI
|.|.|| ||| ....
eeavkrgsgDnitlviik
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 317-403 | 6.4e-10 | 31.6 | In-house | 201-307 (309) | alignment | ||
Range on Protein: 317-403
Range on HMM: 201-307/309.0
LAVTRSLGDH-----SMKDHVI-GDPYKRSIKLDSGHT-HLILACDGLWDVTSDQDAVDLILNETEAQKM--------SDKLLLHALKKGST-----DNI
|||.||||| .. .|. .|. .|| .. ..||| ||||.| . .|||... .| | ... . .|. .||.. .. ||.
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnv
SIIVVIL
|.|||||
svivvil
|
|||||||||
subfamily_Choan-PPM-1_pd | Subfamily Choan-PPM-1 | 317-387 | 2.1e-07 | 22.4 | In-house | 223-295 (317) | alignment | ||
Range on Protein: 317-387
Range on HMM: 223-295/317.0
LAVTRSLGDHSMKD-HVIGDPYKRSIKLDSGHTHLILAC-DGLWDVTSDQDAVDLILNETEAQKMSDKLLLHA
| .|.||| . .| || || || || . .. .... ||. | . .| .| .|. . |.. |..| |
lqltkslGhkllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcdda
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 336-383 | 1.3e-06 | 20.7 | In-house | 274-321 (398) | alignment | ||
Range on Protein: 336-383
Range on HMM: 274-321/398.0
PYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEAQKMSDKL
| | || . |.|| |||||. |....|.|. . .. .| ....
PevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv
|
|||||||||
PPM_PTC7_SpoIIE_motif | 341-401 | 3.7e-09 | 30.1 | In-house | 7-78 (81) | alignment | |||
Range on Protein: 341-401
Range on HMM: 7-78/81.0
IKLDSGHThLILACDGLW-------DVTSDQDAVDLILNE--TEAQKMSDKLLLHALKKG---STDNISIIVV
..| | . |.|..|||. .. .......|. .. ..|...|||. ..|. | ..|.|...|.
fqLkpgdv.llLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevlengsgereDDitllvl
|
|||||||||
PPM_PTC7_motif | 351-396 | 1.3e-14 | 47.4 | In-house | 1-51 (51) | alignment | |||
Range on Protein: 351-396
Range on HMM: 1-51/51.0
ILACDGLWDVTSDQDAVDLILNETEA-----QKMSDKLLLHALKKGSTDNI
|||.|||||| |||.||||. . .. |. . || .||..||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
|