Gene DDB_G0284243 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP107_AA protein Get Run
DdisP107_AA_146-403 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 142-241 9.7e-11 34.3 In-house 7-103 (473) alignment 
Range on Protein: 142-241
Range on HMM: 7-103/473.0
TEPSSKTRSVRDFGVSFEKNARYRRTMEDEHVIIDCFggDANQGYFAIYDGHGGRGAVEFTAKTLHvNLLDEINKSPEGDILELFRNSYLLTDKQMNESE
.| .|...| ... ...     .|  .|| |  |  .  | .   ||.||||||.   ...||.|  .|| . .   |||. . .....|  |..... |
vekesedesneelsygasamqGwrvsqEDahncitdl..dedtslfavyDGHGGkevakyvakklp.dllkaqkgykegdvekaleeaflalDeklkaee
subfamily_PPM1A_pd Subfamily PPM1A 147-403 3.7e-83 272.1 In-house 8-280 (282) alignment 
Range on Protein: 147-403
Range on HMM: 8-280/282.0
KTRSVRdFGVSFEKNarYRRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLD-------EINKSPEGDILELFRNSYLLTDKQMNE
.....| .|||  ..  .|..|||.|... ..|. .....||..|||.|. ......|.|. |.|.       ....|.. ...| .|...| .|....|
egnglr.ygvssmqg..wrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeaire

SEIQFS-----GTTSITALIRknpvdgEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMKD----
.. . .     |.|..|.|..      ||.|..||.||.|||.|.|. |..|..|||.|.|.| |||..|||.|...|||| |||.|.|||...|.    
lstdlktadksGsTavtvlvs......ekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeek

-----HVIGDPYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNE----TEAQKMSDKLLLHALKKGSTDNISIIVVIL
     .|...|. .||. .. ...|.|||||.|||.||...|.|. ..    .|.......|. .||.|||.||.|..||..
kaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
PP2Cc_SM00332 147-401 1.2e-65 214.7 In-house 3-274 (274) alignment 
Range on Protein: 147-401
Range on HMM: 3-274/274.0
KTRSVRDFGVSFEKNARYRRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPE---GDILELFRNSYLLTDKQMNESEI-
...|. ..  .. ..  .|..||| ||.. ..   .. ..|...|||||  ...|..| |. .| .|..|  .    |. |. ....| ||....|.|  
esgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqs

-----QFSGTTSITALIRKNPvdgekyLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMK-------D
     . ||.| ..||..|.       |||||.|| |||.| |. | .||.|||..|..|.||| .|||.| .||||| |||.|..||| .|        
kelenalsGstavvallkked......lyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknkklkep

HVIGDPYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNET------EAQKMSDKLLLHALKK-GSTDNISIIVV
... .|    ..|.| .  ||||.|||||| |.|..||.. .        ..|.....|  .|... ||.|||...||
yitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
0034914 PP2C-like 151-403 1.8e-68 223.4 In-house 18-290 (295) alignment 
Range on Protein: 151-403
Range on HMM: 18-290/295.0
VRDFGVSFEKNARYRRTMEDEHVIIDCFGG-DANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDE------INKSPEGDILELFRNSYLLTDKQMNESEIQ
   . |..  .  .|...|| .... ..   . ....|...|||||  | |. ...|. .||..      .. ... ||.| .|...| .|... |  ..
llllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelall

-----FSGTTSITALIRKNpvdgekYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMK---------
     .|||| ..||||.|      .|||||.|| |||...|.....|..||| ....|..|| .|||.| .|||||.|||||.|||...|         
rpelagsGtTavvalirgn......klyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllle

DHVIGDPYKRSIKLD-SGHTHLILACDGLWDVTSDQDAVDLILN----ETEAQKMSDKLLLHALKKGSTDNISIIVVIL
 .|.  |. ....|. . .  |.||.|||||| |....||.. .     .........|. .||..||.|||...|| |
plvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 153-402 1.7e-66 217.1 In-house 5-252 (255) alignment 
Range on Protein: 153-402
Range on HMM: 5-252/255.0
DFGVSFEKNARYRRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPEgDILELFRNSYLLTDKQMNESEiQFSGTTSITA
 | |.| .    | ||||| ||   | .. .. |.|..|||||| | .|....|.  | . ..  .  . .. ....|  .. |..|   .| |||....
rfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnna.nPvkslkkaykeistqiserp.kfiGttaasv

LIRKNpvdgekYLYVANAGDARAVVC-HNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNG----RVNGILAVTRSLGDHSMKDHVIGDPYKR-SIKLDSG
|| ..      . |.|| ||.|.|.| .. .|.|||.||| |...| ||| ..||.| ..    |||| |||.|.|||  .. .|. ||.   |..    
liied......kvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskk

HTHLILACDGLWDVTSDQDAVDLILNETEAQKMSDKLLLHALKKGSTDNISIIVVI
. .|||||||.||. ||..||..... ....| . ||  .| ..|||||||.||. 
dkflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisvivik
subfamily_PP2D1_pd Subfamily PP2D1 153-216 2.6e-17 55.7 In-house 2-65 (492) alignment 
Range on Protein: 153-216
Range on HMM: 2-65/492.0
DFGVSFEKNARYRRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINK
 .|.  .||.|.. .|||.... | || |.|...|.||||. |. | | .||.||. ||.|..|
avGiCedknsrWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelek
PP2C Protein phosphatase 2C 155-396 5.7e-68 222.2 Pfam-A 2-255 (255) alignment 
Range on Protein: 155-396
Range on HMM: 2-255/255.0
GVSFEKNARYRRTMEDEHVIID---CFGGDANQGYFAIYDGHGGRGAVEFTAKTLHvNLLDEINKSPEG-DILELFRNSYLL-TDKQMNE---S-EIQFS
.|..... ..|..|||.|....   . .|. . ..||..|||||| | ......|. ..|.|  . .|. .  ...|.|.|  ||....    . | . |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfladtdeelksskantepsks

GTTSITALIRKNPvdgekyLYVANAGDARAVVCHNKVAE-RLSYDHKGSDPEEVKRIDAAGGFVC-NGRVNGILAVTRSLGDHSMKD----HVIGDPYKR
|.|...||||..       |||||.||.|||.| .. |. .|..||| ||..|..|| .|||.|  |||||| |||.|.|||. .|.    .|. .|. .
Gstavvalirgkk......lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvt

SIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETE----AQKMSDKLLLHALKKGSTDNI
|.||.. .  ||||.|||||| |||.||||. .| .    .......|. .|...||.|||
svklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 155-396 5.7e-68 222.2 In-house 2-255 (255) alignment 
Range on Protein: 155-396
Range on HMM: 2-255/255.0
GVSFEKNARYRRTMEDEHVIID---CFGGDANQGYFAIYDGHGGRGAVEFTAKTLHvNLLDEINKSPEG-DILELFRNSYLL-TDKQMNE---S-EIQFS
.|..... ..|..|||.|....   . .|. . ..||..|||||| | ......|. ..|.|  . .|. .  ...|.|.|  ||....    . | . |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfladtdeelksskantepsks

GTTSITALIRKNPvdgekyLYVANAGDARAVVCHNKVAE-RLSYDHKGSDPEEVKRIDAAGGFVC-NGRVNGILAVTRSLGDHSMKD----HVIGDPYKR
|.|...||||..       |||||.||.|||.| .. |. .|..||| ||..|..|| .|||.|  |||||| |||.|.|||. .|.    .|. .|. .
Gstavvalirgkk......lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvt

SIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETE----AQKMSDKLLLHALKKGSTDNI
|.||.. .  ||||.|||||| |||.||||. .| .    .......|. .|...||.|||
svklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 156-396 7.3e-68 221.8 In-house 3-259 (259) alignment 
Range on Protein: 156-396
Range on HMM: 3-259/259.0
VSFEKNARYRRTMEDEHVIID---CFGGDANQGYFAIYDGHGGRGAVEFTAKTLHvNLLDEINKSPEG-DILELFRNSYLL--TDKQMNE---S-EIQFS
...... ..|..||| |.. .   . .|. . ..||..|||||| | ......|. . |.|    .|. .  . .|.|.|   ||. ..    . | . |
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehle.eilkerksfeeleklekalrksflaldtdeelksseantepsts

GTTSITALIRKNPvdgekyLYVANAGDARAVVCHNKVAE-RLSYDHKGSDPEEVKRIDAAGGFVC---NGRVNGILAVTRSLGDHSMKD------HVIGD
|.| ..|||...       |||||.||.|||.| .. |  .|..||| |...|..|| .|||.|    |||||| |||.|..||. .|.      .|. .
GstAvvalitgsk......lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsae

PYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEA---QKMSDKLLLHALKKGSTDNI
|.  |.|.|. . .||||.|||||| |||.||||. .| ..   .. ..||. .|...||.|||
PdisstkideedefliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
PPM_PTC7_SpoIIE 156-395 2.9e-35 115.2 In-house 3-229 (230) alignment 
Range on Protein: 156-395
Range on HMM: 3-229/230.0
VSFEKNARYRRTMEDEHVIID---CFGGDANQGYFAIYDGHGGRGavEFTAKTLHvNLLDEINkSPEGD-ILELFRNSYLLTDKQMNESeIQFSGTTSIT
... .. ..|..||| |.. .   . .|.    .....||||||    .....|. ..|.|.   ....   |..|...|. .......  . ||.| . 
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllr.talrela.faglekpeeilrrlnlalaadlede.psssgaTavv

ALirknpVDGEK-YLYVANAGDARAVVCHNKVAerlsydhkgsdpeEVKRIdAAGGFV-C---NGRVNGILAVTRSLGDHSMKD---HVIGDPYkRSIKL
||     .|...  |||||||| ........               |..|| .|||..     .|||.| |||... ||  ...    |   |.  | ..
al.....idpstgklyvanaGdsppllvrddgg.............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.tsdge

DSG-HTHLILACDGLWDVTSDQDAVDLILNETEAQkMSDKLLLHALKKGSTDN
. | . .||||.|||||| |.|..|||...| |.  ....|| ...  .....
lfgkdeflilasdglwdvlspqelvdlvrdelekp.aaeglleDDitllvvrv
subfamily_PPM1D_pd Subfamily PPM1D 157-310 4e-18 58.6 In-house 5-173 (309) alignment 
Range on Protein: 157-310
Range on HMM: 5-173/309.0
SFEKNARYRRTMEDEHVIIDCF---GGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLD--EINKSPEGDILELFRNSYLLTDKQMNESEIQ--------
. | ..  |. |||  .|       . . .. ..|..|||||. | .|. . |  .. .  ..  |.. |.||  |...| | ..|...  .        
tseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgl

--FSGTTSITALIRKNpvdgekYLYVANAGDARAVVCHNKV------AERLSYDHKGSDPEEVKRIDAAGGFVCN
   .|||  . .||..       ||||. ||...|.  ..       |. |  ||| ..|||..||. .|| | .
lstaGttasvviirre......klyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
subfamily_PPM1E_pd Subfamily PPM1E 162-403 1.7e-56 184.4 In-house 12-262 (265) alignment 
Range on Protein: 162-403
Range on HMM: 12-262/265.0
ARYRRTMEDEHVIIDCF----G--GDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPEGDilELFRNSYLLTDKQMNES---EIQFSGTTSITA
   ||.||| ||... .    .  .. .. .||..|||||  | ...|. || .| .. .   .    | ..... |||... .    |   ||.|....
knkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa..ealkeafkltDerflqkaereklksGstavvv

LIRKNPvdgekyLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCN---GRVNGILAVTRSLGDHSMKDHVIGDPYKRSIKLDSGHTH
||.|.       ||||  ||..|.....  | .|   || ....| |||..|||.|..    ||||.|.|.|..|| . |..|.|..   ...||. .  
liekdq......lyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgseey

LILACDGLWDVTSDQDAVDLILNET-----EAQKMSDKLLLHALKKGSTDNISIIVVIL
|||||||||||  ....|.|. .       . .... .|. .| ..||.|||...||.|
lilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
0049733 PP2C-like 163-402 3.4e-53 173.3 In-house 13-232 (235) alignment 
Range on Protein: 163-402
Range on HMM: 13-232/235.0
RYRRTMEDEHVIidcfggdaNQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPEGDILELFRNSYLLTDKQMNESEIQF-----SGTTSITALIRkn
|.|...|| ...        ....||..|||||  | |. ...|. .||... . .. |..|..|...| ..... |  ..      .||| ..||..  
rvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTavvalld..

pvdgEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVcngRVNGILAVTRSLGDHSMKdhvigdPYKRSIKLDSGHtHLILACDGL
    ...|||||.|| ||...... ...|..||. ....|..|| .|||.|   ||.|.||.||.|||. .|      |. ....|..|.  |.||.|||
....ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk......pdvtvlelepgd.flllasDGl

WDVTSDQDAVDLILNeTEAQKMSDKLLLHALKKGSTDNISIIVVI
||| ||...|||. . ...... ..|. .||..|..|||...|| 
wdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvvvvr
subfamily_PPM1G2_pd Subfamily PPM1G2 163-403 6.7e-52 169.2 In-house 28-286 (287) alignment 
Range on Protein: 163-403
Range on HMM: 28-286/287.0
RYRRTMEDEHVI-IDC--FGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSpEGDILELFRNSYLLTDKQMNES---EIQFSGTTSITALIRK
 ||..||| |..  .      | .  .||..|||||. . ....| |.  .    . . || . .......| ||... .    . . .|.|....||..
GyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk.egaleqilkdafletDeellkdeklkdesaGstavvvlike

NPvdgekyLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMKDHVIGDPYKR---------SIKLDSGH
.       ||||||||.|||....  .. ||.||| .. .| ||| ||||||  .|||| ||. |.|||.. |..|   |  .           |||. .
ek......lyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldedd

THLILACDGLWDVTSDQDAVDLI----LNETEAQKMSDKLLLHALKKGST------DNISIIVVIL
  |.|||||.||| .... |||.     .... ......|| ..|.. |       ||.....|.|
eflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
subfamily_ILKAP_pd Subfamily ILKAP 164-401 4.1e-40 130.8 In-house 15-290 (293) alignment 
Range on Protein: 164-401
Range on HMM: 15-290/293.0
YRRTMEDEHVIIDCFGGD---A-----NQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPE----GDILELFRNSYLLTDKQMNE----SEIQ-FSG
 | .|.|.|||.. .  .   .     .  |.|..|||.|. | ||.|..|| ..|... ||       .|   . .|.  ||... .    .. .   |
ereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvWkdG

TTSITALIRKNpvdgekYLYVANAGDARAVVCHNKVAER------LSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMKDH-VIGDPYKR
.| .. |.  |       ||||| ||..||.. .| . .      |. ||.  . || |||. |||.| .|||.|.| |.||.||   |   ||  |  .
statvvlvldn......vlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlGvistPdvk

SIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEAQ--------------------KMSDKLLLHALKKGSTDNISIIVV
 ..|.    ...|||||||.| | ...|. ||.  |..                      ...|  .|.|.||.||.....|
kceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllv
subfamily_PPM1L_pd Subfamily PPM1L 165-402 4.5e-44 143.7 In-house 16-265 (269) alignment 
Range on Protein: 165-402
Range on HMM: 16-265/269.0
RRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEI-----NKSPEG--DILELFRNSYLLTDKQMNES---EIQFSGTTSITALI
|  |||   | .    .... .||..|||||  | ||. . |  ......     .|  .   .  .|. .  |  |... |    . . .|||.. ||.
rprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGttalialv

RknpvdgEKYLYVANAGDARAVVCHNK-VAERLSYDHKGSDPEEVKRIDAAGGFVC-NG--RVNGILAVTRSLGDHSMKDH--VIGDPYKRSIKLDSGHT
.      |. | ||| ||.| |.. ..  |  ||.|||  ...| |||  ||||.. .|  ||.|.||..|.|||. .||.  || ||   ...||  . 
q......esdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdlddhkp

H-LILACDGLWDVTSDQDAVDLILNETEAQKMSDK-LLLHALKKGSTDNISIIVVI
. ||||.|||||  |...||  |... .  ..  | | |.. |.||.|||...|| 
eflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvk
subfamily_KAPP-like_pd Subfamily KAPP-like 168-403 5.3e-39 126.9 In-house 12-266 (266) alignment 
Range on Protein: 168-403
Range on HMM: 12-266/266.0
MEDEHVIIDCFGGDA------NQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINK-------SPEGDILELFRNSYLLTDKQMNESEiqFSGTTSITALI
||| .. |  .. .       | . ||..||| |.|| . . | .  .| . ...        .  |  .|..|..   |..... |  . |.|.  ||.
medvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfe..yeGatatlalv

RKNPvdGEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNG--RVNGIlAVTRSLGDHSMKDHVI---GDPYK-RSIKLDSGHT
 ..     .|| ||| ||. | ...   .  ||.|||  |||| .||   |  ....  |.||. ||.|.|||| .|.  |   ..||    | |   . 
wsdG..qqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdk

HLILACDGLWDVTSDQDAVDLILN----ETEAQKMSDKLLLHALKKG-STDNISIIVVIL
.||.| |||||| | .||.. .      .. ..||.. ||  |..   . ||.|.||| |
flivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 168-403 1.9e-36 118.3 In-house 11-276 (276) alignment 
Range on Protein: 168-403
Range on HMM: 11-276/276.0
MEDEHVIIDCFGGDA------NQGYFAIYDGHGGRGAVEfTAKTLHVNLLDEINKS-------------PEGDILELFRNSYLLTDKQMNESEiqFSGTT
||| .. |  .. .       | . ||..||| |.|| . .|| |  . |  . ||             .  |  .|. . .   |..... |  . |.|
medvslaiyplldekdlsncsnialfavfdGhaGkGaad.aakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfe..yeGat

SITALIRKNP----VDGEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNG--RVNGIlAVTRSLGDHSMKDHVI---GDPYK-
.  ||. ..      . ..|| ||| ||. | ...   .  ||.||| .||||..||   |  ....  |.||. ||.|.|||| .|.  |   ..||  
atlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvs

RSIKLDSGHTHLILACDGLWDVTSDQDAVDLILN----ETEAQKMSDKLLLHALKKG-STDNISIIVVIL
  | |   . .||.| |||||| | .||.. .      .. ..||.. ||  |..   . ||.|.||| |
nrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_PPM1H_pd Subfamily PPM1H 175-216 6.3e-06 18.2 In-house 53-94 (404) alignment 
Range on Protein: 175-216
Range on HMM: 53-94/404.0
IDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINK
 . .   ..  ||...|||.| ||   ..|.||  | .....
ekseeeklplayfglfDGhaGsgaalvaskllhkhlkekled
PP2C_SIG_SM00331 178-401 1e-11 37.8 In-house 24-215 (217) alignment 
Range on Protein: 178-401
Range on HMM: 24-215/217.0
FGGDANQGYFAIYDGHG-GRGAVEFTAKTLHvnLLDEINKSPeGDILELFRNSYLLTDKQmneSEIQFSGTTSITALIrkNPVDGEkyLYVANAGDARAV
.  .. .  ... ||.| |  | ........  .|.|. ..   .. .....   . ...   .| . ...| . ||.  .. .|.  |..||||| | .
vklnegrlllvvaDgmGkGlaAaaassqlrt..alrellseg.eelsqalkrlnraiyee...keekgmfaTlllaly..dfssgk..lsyanaGdsrpy

VCHnkvAERLSYDHKGsdpeevkridaaggfvcngrvngilAVTRSLG--DHSMkdhvigdPYKRSIKLDSGHThLILACDGLWDVTSDQ----DAVDLI
. .    ..| ...|                            .. ||  ....       .. |...|. | . |.|. |||... |..    . . .|
llr...dgklveilkd.........................vegaplGlepevs.......vdirelelekgdl.lllytDGltearsekgfaeerleei

LNET---EAQKMSD----KLLLHALKKGSTDNISIIVV
| ..   |||....    .|| .|  ..  |.|...||
ledlvdseaqelaqkiveellelakgsngeDdiTvvvv
subfamily_PPM1K_pd Subfamily PPM1K 181-402 1.4e-38 125.5 In-house 28-257 (263) alignment 
Range on Protein: 181-402
Range on HMM: 28-257/263.0
DANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEInkSPEGDILELFRNSYLLTDKQM--------NESEIQFSGTTSITALIRknpvDGEKyLYVANAGD
| .  |.|..|||.|  |..|. . |.  | .      | |. ....|...  ||..         |.| . ||||.  .|.|    || . | .|. ||
dpellyvavfdGhaGsaaadfvhdklekilkrll..ekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllr....dGte.lvlaslGd

ARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVC-----NGRVNGILAVTRSLGDHSMKDH-VIGDPYKRSIKLDSG-HTHLILACDGLWDVTSDQD
.||..| |  |..|. ||. .  || .|| ||||.|      . .||| ||.||||||  .| . || .|  .|.|.| .  . |.|  ||. .| ..|.
srailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqe

AVDLILNETEAQKMSDKLLLHALKKGSTDNISIIVVI
  ||.   .. .. .. |   ||. || || ...|| 
lcdlvrlchdpeeaahalteqalqygsednatavvvp
subfamily_PHLPP_pd Subfamily PHLPP 186-402 3.6e-20 64.9 In-house 29-244 (246) alignment 
Range on Protein: 186-402
Range on HMM: 29-244/246.0
YFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPEGdiLELFRNSYLLTDKQMNEsEIQFSGTTSITALIRKNPVDGEK--YLYVANAGDARAVVCHNKVA
 . ..||.  .   .   ....  |..|..|. .    |  .| .| . ... | . .  |.. .  |||...||  |   | ||. |   ||.. |.  
lyGlfdGdrneelssllqrlmkdvlkeevqkdkne..eeymkntllvaqrklGe.aGeklgsaallilirhdkvdPaksfsLevAsvGtlqavliRngkk

ERLSYDHKGSDPeEVKRIDAAGGFVC-NGRVNGILAVTRSLGDHSMKDHVIGDPYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEAQKMSDK
 |||  .. ..  |.|||  | ...  ....||... || ||  ..   |. .|  |...| .    ||.  . ||.| | ..||. . .| ..     |
lrlsksyviekd.elkrikeakaiitednkingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavrkeedplvaAkk

LLLHALKKGSTDNISIIVVI
|   |   | .|..|..|| 
lvdlaqsygaadsvsvlvvr
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 187-336 3.5e-18 59.1 In-house 24-194 (292) alignment 
Range on Protein: 187-336
Range on HMM: 24-194/292.0
FAIYDGHG--GRGAVEFTAKTLHVNLLDEINksPEGDILELFRNSYLLTDKQMNESEIQFSGTTSITALIRKNPvDgEKYLYVANAGDARAVVCH-----
 |..||||  |.   .....|| |.||.  .  .  .. | . .  | .  ..... |.    .. ..   . . | .. |..|| ||.||..       
aavldGhGvnGdkvaqlaedtlevelleltr..qlqelsealllrildiaakldkltidaresattavvcarvr.d.dralilanvGdsrallgrclggs

NKVAERLSYDHKGSDPEEVKRIDAAGGFVC-----------NGRV------NGILAVTRSLGDH-SMKDHVIGDP
..    || ||| .||.| .|| .|||.|              ||      .| ||..|.|||   ..  |. .|
dyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaeP
subfamily_PPM1H_pd Subfamily PPM1H 230-291 1.7e-07 23.4 In-house 144-202 (404) alignment 
Range on Protein: 230-291
Range on HMM: 144-202/404.0
YLLTDKQMNESEIQFSGTTSITALIRknpVDGEKYLYVANAGDARAVVCHNKVAERLSYDHK
.|  |.|... . ..  .   |||.    .  .. ||||||||.||......    || |. 
flemDeqiarereayrikGGCtalva...lvllgklYvanaGDsRailvrkdeiiplsadft
subfamily_PDP_pd Subfamily PDP 234-329 4.1e-11 35.6 In-house 140-241 (398) alignment 
Range on Protein: 234-329
Range on HMM: 140-241/398.0
DKQMNE-SEIQFSGTTSITALIRKNPvdgekyLYVANAGDARAVVCHNK-----VAERLSYDHKGSDPEEVKRIDAA------GGFVCNGRVNGILAVTR
.|...|  .  .||.....|||...       |.|||.||.|||.. ..      | .|| |. .. .|||.|| ..         . |||. | |. .|
ekslreallvalsGacallaliegte......lhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlR

SLGDHSMK
  ||   |
AFGdvryK
subfamily_PPM1G_pd Subfamily PPM1G 237-380 1e-32 106.8 In-house 288-435 (473) alignment 
Range on Protein: 237-380
Range on HMM: 288-435/473.0
MNESEIQFSGTTSITALIRKNpvdgekYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVC-NGRVNGILAVTRSLGDHSMKDHVIG-
 .|.. . |||| . ||....       |.||||||.|.|...| .|  ||.|||  |..| .||..||| |  .||||| | . | ||||. |      
ekeepGedsGttAvvaLlkek......klivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLp

--------DPYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEAQKMS
         |  .  .| . .  |.|||||.|.| . |. || . .. . .. |
lkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees
subfamily_TAB1_pd Subfamily TAB1 245-330 6.5e-12 37.9 In-house 129-214 (333) alignment 
Range on Protein: 245-330
Range on HMM: 129-214/333.0
SGTTSITALIRKNpvdgekYLYVANAGDARAVVCH---NKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGI---LAVTRSLGDHSMKD
 ||| . |||  |       |||||.||.||....   ..  . || ||.   ..|..|.   |  . . . |..      |||.||...| 
gGttAvvalifnn......kLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkk
Subfamily Dicty-PPM1L-like 245-306 9.8e-07 20.9 In-house 211-270 (305) alignment 
Range on Protein: 245-306
Range on HMM: 211-270/305.0
SGTTSITALIRknPVDGEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGG
 |  ... |.   | . .. | ||.|.| . |.. . ..| |||...  ...|. |.   ..
kGdknlkelvi..PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqk
subfamily_PP2D1_pd Subfamily PP2D1 264-372 7.7e-25 80.5 In-house 189-304 (492) alignment 
Range on Protein: 264-372
Range on HMM: 189-304/492.0
YLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVC----NGRVNGILAVTRSLG---DHSMKDHVIGDPYKRSIKLDSGHTHLILACDG
 ||.||||. .||.|.. .| .|  .|   ...| .|.  ||. |     ||.||||| .|| ||   |  .|  || .|. .|.|||     |.||  |
vlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnG

LWDVTSDQDAVDLILN
||.| |... . |. .
lWevlseeevlsLvkq
Subfamily Dicty-PPM1L-like 300-402 3.2e-10 32.3 In-house 185-302 (305) alignment 
Range on Protein: 300-402
Range on HMM: 185-302/305.0
RIDAAGGFVCN-G--RVNGILAVTRSLGDHSMKDHVIGDPYKRSIKL-DSGHTHLILACDGLWDVTSDQDAVDLIL---NETEAQK--------MSDKLL
||. ... . | |  .||..| . || || ..|  || .. .    . ...   |.|| ||||.| | || |. ..   ...  ||        .|    
rieslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviv

LHALKKGSTDNISIIVVI
  |.|.|| ||| .... 
eeavkrgsgDnitlviik
subfamily_PPM1D_pd Subfamily PPM1D 317-403 6.4e-10 31.6 In-house 201-307 (309) alignment 
Range on Protein: 317-403
Range on HMM: 201-307/309.0
LAVTRSLGDH-----SMKDHVI-GDPYKRSIKLDSGHT-HLILACDGLWDVTSDQDAVDLILNETEAQKM--------SDKLLLHALKKGST-----DNI
|||.|||||       .. .|.  .|.    .||  .. ..||| ||||.| . .|||... .| | ...        . .|. .||.. ..     ||.
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnv

SIIVVIL
|.|||||
svivvil
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 317-387 2.1e-07 22.4 In-house 223-295 (317) alignment 
Range on Protein: 317-387
Range on HMM: 223-295/317.0
LAVTRSLGDHSMKD-HVIGDPYKRSIKLDSGHTHLILAC-DGLWDVTSDQDAVDLILNETEAQKMSDKLLLHA
| .|.||| . .|   || ||  ||  || . .. .... ||. |  . .| .| .|. . |.. |..|   |
lqltkslGhkllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcdda
subfamily_PDP_pd Subfamily PDP 336-383 1.3e-06 20.7 In-house 274-321 (398) alignment 
Range on Protein: 336-383
Range on HMM: 274-321/398.0
PYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEAQKMSDKL
|   | || .    |.|| |||||. |....|.|. . .. .| ....
PevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv
PPM_PTC7_SpoIIE_motif 341-401 3.7e-09 30.1 In-house 7-78 (81) alignment 
Range on Protein: 341-401
Range on HMM: 7-78/81.0
IKLDSGHThLILACDGLW-------DVTSDQDAVDLILNE--TEAQKMSDKLLLHALKKG---STDNISIIVV
..|  | . |.|..|||.       .. .......|. ..   ..|...|||. ..|. |   ..|.|...|.
fqLkpgdv.llLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevlengsgereDDitllvl
PPM_PTC7_motif 351-396 1.3e-14 47.4 In-house 1-51 (51) alignment 
Range on Protein: 351-396
Range on HMM: 1-51/51.0
ILACDGLWDVTSDQDAVDLILNETEA-----QKMSDKLLLHALKKGSTDNI
|||.|||||| |||.||||.  . ..     |. . ||  .||..||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni