Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| 0034914 | PP2C-like | 257-496 | 2.8e-30 | 98.3 | In-house | 19-291 (295) | alignment | ||
Range on Protein: 257-496
Range on HMM: 19-291/295.0
FHLNSGVCVIPHPnkRHKgGEDAYFISI-------DQNVIGVADGVGGWGDVGIDPSEYSNTLMKGSKI-GADSQKVERDPLIIMEQGYQYA--------
..|..||. . |.. |||... . |. ..||.||.||. . . . ..|.. . .. . |.. ....... |
lllrvgvasdqGr..rks.neDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellela
---QDVKGSSTCCIVVLSATNNILSANLGDSGFLVIRNNEVIFRTREQQHAFNMPFQ------------------LGTQSIDRPIHS-------------
.. ||.|...|.| | . ||.||| ....||.|... |... ..... .. |... .
llrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvs
-----ITASFPAEKGDLIIMGTDGVFDNLFDDEILEIGEK----YDDPQIIARQVAKRAFEvgcsttiytpfaknaghngyiynGGKLDDITVVVGLVD
.. .. |..|......||..|.| ..||..| . ..|.. .|......|.. .|. |.||||| ..
aePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla.......................rgsrDNiTvvvvrln
|
|||||||||
| 0049733 | PP2C-like | 262-494 | 1.4e-34 | 112.5 | In-house | 4-232 (235) | alignment | ||
Range on Protein: 262-494
Range on HMM: 4-232/235.0
GVCVIPHPNKRHKGGEDAYFIsiDQNVIGVADGVGGWGDVGIDPSEYSNTLMKGS-KigadsqKVERDPLIIMEQGYQYA------------QDVKGSST
.|... ......| .|||... .. ...||||.||. .. . . .||.. . . |.. .... ...| . . .|
svgaasdigrvrkvneDavlv..glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspelagmgtT
CCIVVLSaTNNILSANLGDSGFLVIRNNEVIFRTREQQHAFNMPFQ--------------------LGtqsiDRPIHSITASFPAEKGDLIIMGTDGVFD
.....| .. . ||.||| ....|.......|...........| || |.... . ... |.||.... .||..|
avvalld.ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggavrvpgrlaltralG....dlllkpdvtvlelepgdflllasDGlwd
NLFDDEILEIGEKyDDPQIIARQVAKRAFEvgcsttiytpfaknaghngyiynGGKLDDITVVVGL
.| |.||... . .|.. .|......|.. .|. |.|||||
vlsdeeivdllrs.ldleeaaerlvelala.......................rggrDNiTvvvvr
|
|||||||||
| PP2C_SIG_SM00331 | 264-493 | 5.1e-17 | 55.1 | In-house | 4-215 (217) | alignment | |||
Range on Protein: 264-493
Range on HMM: 4-215/217.0
CVIPHPNKRHKG-GEDAYFISIDQN---VIGVADGVGgwgdVGIDPSEYSNTLMKGSKIGADSQkveRDPLIIMEQGYQYAQDV-----KGSSTCCIVVL
. |..... . ..| |.. ... .. ||||.| |.. ...| | . . .... .. .... ..... .. . .....
gliaqyyeeatqvsGDyydvvklnegrlllvvaDgmG....kGlaAaaassqlrtalrellseg...eelsqalkrlnraiyeekeekgmfaTlllalyd
SATNNILSANLGDSGFLVIRNNEVIFRTREqqhafNMPFQLGTQSIDRpihSITASFPAEKGDLIIMGTDGVFDNLFDDEileIGEKYDDPQIIARQvaK
..... ||.||| ....|... .... . .....||... . .... |||||... |||.... ... ..|. . . . . .
fssgklsyanaGdsrpyllrdgklveilkd.....vegaplGlepevs...vdirelelekgdllllytDGltearsekg...faeerleeiledlv..d
-RAFEVGCsTTIYTPFAKNAGHNGyiynggkLDDITVVVG
| |.. ... ... .|.|| |||||||
seaqelaq.kiveellelakgsng.......eDdiTvvvv
|
|||||||||
| subfamily_PPTC7_pd | Subfamily PPTC7 | 270-496 | 1.4e-88 | 289.5 | In-house | 5-252 (252) | alignment | ||
Range on Protein: 270-496
Range on HMM: 5-252/252.0
NKRHKGGEDAYFIS--IDQNVIGVADGVGGWGDVGIDPSEYSNTLMKGS-KIGADSQKVERDPLIIMEQGYQYAQDVK----GSSTCCIVVLSATN-NIL
.||.| ||||||.| ...|.||||||||| .|||||||.|..||| . |. ..|.. |..| ..|..||.... | ||||.|||||.... ..
gkrqkageDayfvsseksadvlgvADGVggWrsvGiDpsefsreLmkaceklskeskaeelkPvelleaayqelleekvpvlGssTacivvldksdkkle
SANLGDSGFLVIRNNEVIFRTREQQHAFNMPFQL--------GTQSIDRPIHSITASFPAEKGDLIIMGTDGVFDNLFDDEILEI-----GEKYDDPQII
|||||||||||.|...|.||..||||.||.|.|| |....|.| .. ..||. .|||.|...|||.||||..|||||| ..... |..
sanlGDSgflvvRkgkvvfrskeqqhkfntPyQLsiapegregkvildkpeaadsksfavkkgDiivlatDGlfDNlledeileilkelkeseksslqsl
ARQVAKRAFEVGCSTTIYTPFAKNAGHNGYIYNGGKLDDITVVVGLVD
|...|..|.|.........|||..|..||. ..||| ||||||| .|.
akklaekarelsldpeyespfaqkakkngleasGGKpDDitvvvavvs
|
|||||||||
| PPM_PTC7_SpoIIE | 288-492 | 2.4e-13 | 43.4 | In-house | 34-226 (230) | alignment | |||
Range on Protein: 288-492
Range on HMM: 34-226/230.0
VIGVADGVGgwgdVGIDPSEYSNTLMkgSKIGADSqKVER-DPLIIMEQGYQYA-QDVKGS-----STCCIVVLSATN-NILSANLGDSGFLVIRNNEvi
.. |.|..| |.. . ...| ... . . . . .| |.. ..... .| . . .|...... .. .. ||.||| .|..|...
alvvgdvdG....hGgraalamgllr..talrela.faglekpeeilrrlnlalaadledepsssgaTavvalidpstgklyvanaGdsppllvrddg..
fRTREQQHAFNMPFqLGT-QSIDRPIhsitASFPAEKGDLIIMGTDGVFDNL--FDDEILEIGEKYDdpqIIARQV--AKRAFE------------Vgcs
..||. |...| || . . .... ..|||... |||| .. .|..|. ... |.| . . .
.gererivagglps.lGilpgrvfgv....lavslapGdllllytDGvveaepdtsdgelfgkdefl...ilasdglwdvlspqelvdlvrdelekp...
ttiytpfaknaghngyIYNGGKLDDITVVV
...|.. ||||..|
................aaeglleDDitllv
|
|||||||||
| SpoIIE | Stage II sporulation protein E (SpoIIE) | 326-492 | 7.2e-13 | 40.8 | Pfam-A | 37-189 (193) | alignment | ||
Range on Protein: 326-492
Range on HMM: 37-189/193.0
ERDPLIIMEQGYQYA-QDVKGS---STCCIVV-LSATNNILSANLGDSGFLVIRNNEvifRTREQQHAFNMPfqLGTQSIdrpIHSITASFPAEKGDLII
. .| ..|. ... .... . |..... .|... ||.|.. .|..|... .|... .....| || . . .|... |.|||..
glepaevlerlnealarnleeeerfatavlaeydpstgkleyanaGhpppllvrpdg...gtkfllvstglp..lGilpe...adyeeaelqlepgdlll
MGTDGVFDNLfdDEILEIGEKYDDPQIIARQvAKRAfEVGCSTTIYTPFAKnaghngyIYNGGKLDDITVVV
. ||||... |. |. .| . ...|. ... .. ... . . ...|.. ||||..|
lyTDGvtEar..dpdgelfgkerllallaea.eges.leelldalveelle.......lgsgeleDDitllv
|
|||||||||
| SpoIIE | Stage II sporulation protein E (SpoIIE) | 326-492 | 7.2e-13 | 40.8 | In-house | 37-189 (193) | alignment | ||
Range on Protein: 326-492
Range on HMM: 37-189/193.0
ERDPLIIMEQGYQYA-QDVKGS---STCCIVV-LSATNNILSANLGDSGFLVIRNNEvifRTREQQHAFNMPfqLGTQSIdrpIHSITASFPAEKGDLII
. .| ..|. ... .... . |..... .|... ||.|.. .|..|... .|... .....| || . . .|... |.|||..
glepaevlerlnealarnleeeerfatavlaeydpstgkleyanaGhpppllvrpdg...gtkfllvstglp..lGilpe...adyeeaelqlepgdlll
MGTDGVFDNLfdDEILEIGEKYDDPQIIARQvAKRAfEVGCSTTIYTPFAKnaghngyIYNGGKLDDITVVV
. ||||... |. |. .| . ...|. ... .. ... . . ...|.. ||||..|
lyTDGvtEar..dpdgelfgkerllallaea.eges.leelldalveelle.......lgsgeleDDitllv
|
|||||||||
| PP2C_2 | Protein phosphatase 2C | 342-435 | 2.9e-07 | 23.0 | Pfam-A | 93-186 (212) | alignment | ||
Range on Protein: 342-435
Range on HMM: 93-186/212.0
DVKGSSTCCIVVLSATNNILSANLGDSGFLVIR-NNEVIFRTREQQHAF-NMpfqlgTQSIDRP---IHSITASFPAEKGDLIIMGTDGVFDNLFDDEI
..| .| ..... . ..|.....||.. .|.. ..|| . .... . |. |...... . . ....|.|| ... |||| |.| ..|
elkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyane.....ttfltsedaeeelrirrlklepgdalllmTDGvsdslrkeep
|
|||||||||
| PP2C_2 | Protein phosphatase 2C | 342-435 | 2.9e-07 | 23.0 | In-house | 93-186 (212) | alignment | ||
Range on Protein: 342-435
Range on HMM: 93-186/212.0
DVKGSSTCCIVVLSATNNILSANLGDSGFLVIR-NNEVIFRTREQQHAF-NMpfqlgTQSIDRP---IHSITASFPAEKGDLIIMGTDGVFDNLFDDEI
..| .| ..... . ..|.....||.. .|.. ..|| . .... . |. |...... . . ....|.|| ... |||| |.| ..|
elkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyane.....ttfltsedaeeelrirrlklepgdalllmTDGvsdslrkeep
|
|||||||||
| PPM_PTC7 | 344-382 | 4.9e-06 | 19.2 | In-house | 99-136 (259) | alignment | |||
Range on Protein: 344-382
Range on HMM: 99-136/259.0
KGSSTCCIVVLSATNNILSANLGDSGFLVIRNNEVIfRT
. | ....|.| ... ||.|||.....|..... .
stsGstAvvalitgsklyvAnvGDSravLcrsgnav.kq
|
|||||||||
| PPM_PTC7_SpoIIE_motif | 408-492 | 6.7e-10 | 32.5 | In-house | 4-77 (81) | alignment | |||
Range on Protein: 408-492
Range on HMM: 4-77/81.0
TASFPAEKGDLIIMGTDGVFDNL-------FDDEILEIGEKY--DDPQIIARQVAKRAFEvgcsttiytpfaknaghngyIYNGGKLDDITVVV
.|.|. ..||.....|||.... ..| |.. .. ..| .|... ... | ..|.. ||||..|
eaefqLkpgdvllLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevle....................ngsgereDDitllv
|
|||||||||
| PP2Cc_SM00332 | 413-492 | 1.3e-06 | 21.0 | In-house | 210-273 (274) | alignment | |||
Range on Protein: 413-492
Range on HMM: 210-273/274.0
AEKGDLIIMGTDGVFDNLFDDEILEIGEKYD------DPQIIARQVAKRAFEVgcsttiytpfaknaghngyiynGGKLDDITVVV
......|. .||..|.| ..|. .| .| ||| .| .... | . ||. |.|||||
tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr......................ggseDniTvvv
|
|||||||||