Gene DDB_G0280067 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PTC7
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP109_AA protein Get Run
DdisP109_AA_256-496 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 257-496 2.8e-30 98.3 In-house 19-291 (295) alignment
Range on Protein: 257-496
Range on HMM: 19-291/295.0
FHLNSGVCVIPHPnkRHKgGEDAYFISI-------DQNVIGVADGVGGWGDVGIDPSEYSNTLMKGSKI-GADSQKVERDPLIIMEQGYQYA--------
..|..||. .     |..  |||... .       |. ..||.||.||.    .  . . ..|..  .     ..  . |.. ....... |        
lllrvgvasdqGr..rks.neDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellela

---QDVKGSSTCCIVVLSATNNILSANLGDSGFLVIRNNEVIFRTREQQHAFNMPFQ------------------LGTQSIDRPIHS-------------
    .. ||.|...|.|   | .  ||.||| ....||.|... |... ..... ..                    |...    .              
llrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvs

-----ITASFPAEKGDLIIMGTDGVFDNLFDDEILEIGEK----YDDPQIIARQVAKRAFEvgcsttiytpfaknaghngyiynGGKLDDITVVVGLVD
     .. ..  |..|......||..|.| ..||..|  .    ..|.. .|......|..                       .|. |.|||||  ..
aePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla.......................rgsrDNiTvvvvrln

0049733 PP2C-like 262-494 1.4e-34 112.5 In-house 4-232 (235) alignment
Range on Protein: 262-494
Range on HMM: 4-232/235.0
GVCVIPHPNKRHKGGEDAYFIsiDQNVIGVADGVGGWGDVGIDPSEYSNTLMKGS-KigadsqKVERDPLIIMEQGYQYA------------QDVKGSST
.|... ......| .|||...  .. ...||||.||.   ..  . . .||..   .        . |.. .... ...|            .   . .|
svgaasdigrvrkvneDavlv..glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspelagmgtT

CCIVVLSaTNNILSANLGDSGFLVIRNNEVIFRTREQQHAFNMPFQ--------------------LGtqsiDRPIHSITASFPAEKGDLIIMGTDGVFD
.....|  .. .  ||.||| ....|.......|...........|                    ||    |....  . ... |.||.... .||..|
avvalld.ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggavrvpgrlaltralG....dlllkpdvtvlelepgdflllasDGlwd

NLFDDEILEIGEKyDDPQIIARQVAKRAFEvgcsttiytpfaknaghngyiynGGKLDDITVVVGL
.| |.||...  . .|.. .|......|..                       .|. |.|||||  
vlsdeeivdllrs.ldleeaaerlvelala.......................rggrDNiTvvvvr

PP2C_SIG_SM00331 264-493 5.1e-17 55.1 In-house 4-215 (217) alignment
Range on Protein: 264-493
Range on HMM: 4-215/217.0
CVIPHPNKRHKG-GEDAYFISIDQN---VIGVADGVGgwgdVGIDPSEYSNTLMKGSKIGADSQkveRDPLIIMEQGYQYAQDV-----KGSSTCCIVVL
. |.....  .  ..| |..  ...   .. ||||.|     |.. ...|  | .  .  ....    ..  ....  .....      .. . ..... 
gliaqyyeeatqvsGDyydvvklnegrlllvvaDgmG....kGlaAaaassqlrtalrellseg...eelsqalkrlnraiyeekeekgmfaTlllalyd

SATNNILSANLGDSGFLVIRNNEVIFRTREqqhafNMPFQLGTQSIDRpihSITASFPAEKGDLIIMGTDGVFDNLFDDEileIGEKYDDPQIIARQvaK
 .....  ||.||| ....|... .... .     .....||...  .     ....  |||||... |||....  ...   ..|. .   . . .  .
fssgklsyanaGdsrpyllrdgklveilkd.....vegaplGlepevs...vdirelelekgdllllytDGltearsekg...faeerleeiledlv..d

-RAFEVGCsTTIYTPFAKNAGHNGyiynggkLDDITVVVG
  | |..  ...   ... .|.||        ||||||| 
seaqelaq.kiveellelakgsng.......eDdiTvvvv

subfamily_PPTC7_pd Subfamily PPTC7 270-496 1.4e-88 289.5 In-house 5-252 (252) alignment
Range on Protein: 270-496
Range on HMM: 5-252/252.0
NKRHKGGEDAYFIS--IDQNVIGVADGVGGWGDVGIDPSEYSNTLMKGS-KIGADSQKVERDPLIIMEQGYQYAQDVK----GSSTCCIVVLSATN-NIL
.||.| ||||||.|   ...|.||||||||| .|||||||.|..||| . |. ..|.. |..|  ..|..||.... |    ||||.|||||.... .. 
gkrqkageDayfvsseksadvlgvADGVggWrsvGiDpsefsreLmkaceklskeskaeelkPvelleaayqelleekvpvlGssTacivvldksdkkle

SANLGDSGFLVIRNNEVIFRTREQQHAFNMPFQL--------GTQSIDRPIHSITASFPAEKGDLIIMGTDGVFDNLFDDEILEI-----GEKYDDPQII
|||||||||||.|...|.||..||||.||.|.||        |....|.| .. ..||. .|||.|...|||.||||..||||||      ..... |..
sanlGDSgflvvRkgkvvfrskeqqhkfntPyQLsiapegregkvildkpeaadsksfavkkgDiivlatDGlfDNlledeileilkelkeseksslqsl

ARQVAKRAFEVGCSTTIYTPFAKNAGHNGYIYNGGKLDDITVVVGLVD
|...|..|.|.........|||..|..||. ..||| ||||||| .|.
akklaekarelsldpeyespfaqkakkngleasGGKpDDitvvvavvs

PPM_PTC7_SpoIIE 288-492 2.4e-13 43.4 In-house 34-226 (230) alignment
Range on Protein: 288-492
Range on HMM: 34-226/230.0
VIGVADGVGgwgdVGIDPSEYSNTLMkgSKIGADSqKVER-DPLIIMEQGYQYA-QDVKGS-----STCCIVVLSATN-NILSANLGDSGFLVIRNNEvi
.. |.|..|     |.. .  ...|   ... . . . .  .|  |.. ..... .| . .     .|......  .. ..  ||.||| .|..|...  
alvvgdvdG....hGgraalamgllr..talrela.faglekpeeilrrlnlalaadledepsssgaTavvalidpstgklyvanaGdsppllvrddg..

fRTREQQHAFNMPFqLGT-QSIDRPIhsitASFPAEKGDLIIMGTDGVFDNL--FDDEILEIGEKYDdpqIIARQV--AKRAFE------------Vgcs
 ..||.  |...|  ||     . .     .... ..|||... |||| ..    .|..|.  ...    |.| .    .   .                
.gererivagglps.lGilpgrvfgv....lavslapGdllllytDGvveaepdtsdgelfgkdefl...ilasdglwdvlspqelvdlvrdelekp...

ttiytpfaknaghngyIYNGGKLDDITVVV
                ...|.. ||||..|
................aaeglleDDitllv

SpoIIE Stage II sporulation protein E (SpoIIE) 326-492 7.2e-13 40.8 Pfam-A 37-189 (193) alignment
Range on Protein: 326-492
Range on HMM: 37-189/193.0
ERDPLIIMEQGYQYA-QDVKGS---STCCIVV-LSATNNILSANLGDSGFLVIRNNEvifRTREQQHAFNMPfqLGTQSIdrpIHSITASFPAEKGDLII
. .|  ..|. ...  .... .    |.....   .|...  ||.|.. .|..|...   .|... .....|  ||  .     .  .|... |.|||..
glepaevlerlnealarnleeeerfatavlaeydpstgkleyanaGhpppllvrpdg...gtkfllvstglp..lGilpe...adyeeaelqlepgdlll

MGTDGVFDNLfdDEILEIGEKYDDPQIIARQvAKRAfEVGCSTTIYTPFAKnaghngyIYNGGKLDDITVVV
. ||||...   |.  |. .| .  ...|.  ...     .. ...  . .       ...|.. ||||..|
lyTDGvtEar..dpdgelfgkerllallaea.eges.leelldalveelle.......lgsgeleDDitllv

SpoIIE Stage II sporulation protein E (SpoIIE) 326-492 7.2e-13 40.8 In-house 37-189 (193) alignment
Range on Protein: 326-492
Range on HMM: 37-189/193.0
ERDPLIIMEQGYQYA-QDVKGS---STCCIVV-LSATNNILSANLGDSGFLVIRNNEvifRTREQQHAFNMPfqLGTQSIdrpIHSITASFPAEKGDLII
. .|  ..|. ...  .... .    |.....   .|...  ||.|.. .|..|...   .|... .....|  ||  .     .  .|... |.|||..
glepaevlerlnealarnleeeerfatavlaeydpstgkleyanaGhpppllvrpdg...gtkfllvstglp..lGilpe...adyeeaelqlepgdlll

MGTDGVFDNLfdDEILEIGEKYDDPQIIARQvAKRAfEVGCSTTIYTPFAKnaghngyIYNGGKLDDITVVV
. ||||...   |.  |. .| .  ...|.  ...     .. ...  . .       ...|.. ||||..|
lyTDGvtEar..dpdgelfgkerllallaea.eges.leelldalveelle.......lgsgeleDDitllv

PP2C_2 Protein phosphatase 2C 342-435 2.9e-07 23.0 Pfam-A 93-186 (212) alignment
Range on Protein: 342-435
Range on HMM: 93-186/212.0
DVKGSSTCCIVVLSATNNILSANLGDSGFLVIR-NNEVIFRTREQQHAF-NMpfqlgTQSIDRP---IHSITASFPAEKGDLIIMGTDGVFDNLFDDEI
..|  .| ..... . ..|.....||.. .|.. ..||   . .... . |.     |......    .  . ....|.|| ... |||| |.| ..| 
elkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyane.....ttfltsedaeeelrirrlklepgdalllmTDGvsdslrkeep

PP2C_2 Protein phosphatase 2C 342-435 2.9e-07 23.0 In-house 93-186 (212) alignment
Range on Protein: 342-435
Range on HMM: 93-186/212.0
DVKGSSTCCIVVLSATNNILSANLGDSGFLVIR-NNEVIFRTREQQHAF-NMpfqlgTQSIDRP---IHSITASFPAEKGDLIIMGTDGVFDNLFDDEI
..|  .| ..... . ..|.....||.. .|.. ..||   . .... . |.     |......    .  . ....|.|| ... |||| |.| ..| 
elkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyane.....ttfltsedaeeelrirrlklepgdalllmTDGvsdslrkeep

PPM_PTC7 344-382 4.9e-06 19.2 In-house 99-136 (259) alignment
Range on Protein: 344-382
Range on HMM: 99-136/259.0
KGSSTCCIVVLSATNNILSANLGDSGFLVIRNNEVIfRT
. | ....|.|   ...  ||.|||.....|.....  .
stsGstAvvalitgsklyvAnvGDSravLcrsgnav.kq

PPM_PTC7_SpoIIE_motif 408-492 6.7e-10 32.5 In-house 4-77 (81) alignment
Range on Protein: 408-492
Range on HMM: 4-77/81.0
TASFPAEKGDLIIMGTDGVFDNL-------FDDEILEIGEKY--DDPQIIARQVAKRAFEvgcsttiytpfaknaghngyIYNGGKLDDITVVV
.|.|. ..||.....|||....         ..| |.. ..    ..| .|... ... |                     ..|.. ||||..|
eaefqLkpgdvllLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevle....................ngsgereDDitllv

PP2Cc_SM00332 413-492 1.3e-06 21.0 In-house 210-273 (274) alignment
Range on Protein: 413-492
Range on HMM: 210-273/274.0
AEKGDLIIMGTDGVFDNLFDDEILEIGEKYD------DPQIIARQVAKRAFEVgcsttiytpfaknaghngyiynGGKLDDITVVV
 ......|. .||..|.| ..|. .| .|        ||| .| .... | .                       ||. |.|||||
tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr......................ggseDniTvvv