Gene spnA in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP111_AA protein Get Run
DdisP111_AA_697-973 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
G-alpha G-protein alpha subunit 8-445 4.2e-66 209.5 Pfam-A 8-388 (389) alignment 
Range on Protein: 8-445
Range on HMM: 8-388/389.0
NKKEKKEEQSPAHSSLAQQHQLAqqqyqlqqqqlqlqyqqhqqqlqlaqqqkqneqnlaqlststssnssvnnttntntnTTNSSSISSNNNNNNNTAVP
.....|....|..|. .....|.                                                         .......||........|  
sesdeklkeapesspseteerlq.........................................................seeekkrssladdiskkaee

ILKAHDFCGTIMILGHTESGKTTLQRQLEFIYGVTDP-TDAKHYQRLIYGNTLATLIRFIENSERLNITL--------SPDNLARVKRIQSQPVELARNR
  |... . ....||..||||.|...|....|. .   .. .... .|| |..  .  ..|. |.|.|.|        |..| .. ....|.  .| ...
ekkkkkrevklLlLGqgeSGKsTilkqfkllykpgfsreeraswraviylnivrsiktilealekleielsssqsstlseeneeqleklksrldplreie

LP------RFPLKLGWDCKCIWEDKVIQSVYNHSKICSEirtPGRPKYYMDRMFKVFDPSYTPTEMDIISAYDQKDTIQSSAIIH-KRFKVDLFGCSGKQ
 .      ... .| .|.| .|.|. .|.|..... .     .   .|..|.. ....|.|.||. ||. |  ..  |..  .   .  .. |. ..|..
atliaepqevleelaedikeLwndpgvqevlkrrrkikl...edsaeyFldnleritspdYvPtddDilrarlkttGiseikfevesgtewrlvDvGGqr

SSPKNWVGLHQnyKPNYIFYVVALKDYFSDHLVATQNtdptivemcnnhihrNLLLESLNSFETLTKSELFDkSLAIYLIFNTSDIFYENIKQYD-LKSC
|  |.|. ...  . ..|...|.|...        .                | | |||. |... ...|.. .  |.|..|  ||. | .|..  |...
serkkWipcfe..dvdaiiFlvslsefdqvlsedesv...............nrleeSlklFksicnnkllk.ntpiiLflNKlDileeKlkkgpklsky

FSEYEGG--NDPEKAVSFISNKFTKFLQNKD--KPYKSHIVNLLDKNNVREEFEGIFDS
| .|||.  ||.|.|.... |||........  .... |... .|..|||. |. . |.
fpsyegdrendyesaskylrnkfkeinrensenrkiythftsatdtenvrkvfaavrdi
PP2Cc_SM00332 698-970 1.9e-62 204.2 In-house 5-274 (274) alignment 
Range on Protein: 698-970
Range on HMM: 5-274/274.0
GSKIKLESGFGSLQGRRKNMEDTHVILNNLMgavtyngppKDIPISYYAVYDGHGGTETSTLLEPTVHNCLVNSQSFRDG----DYEQAFRDAYAEADDI
||. .| .|. | ||.||.||| ||. ..|          .    ....|.|||||.|.. ..   ....| .. .. ..    | |.| ..|. ..|. 
gsnlglsygkssmqgwrksmeDahvvvvdlv.........eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdee

VIEKCE-------KSGSTGVSALLVGNKLYTANVGDSEIVLARAQPnanpkgpvtyePVLLSYKHLASDDQEKKRVTDLGGMIIFNRLFGSLAVSRSFGD
  |. .       .|||| |.|||....|| ||||||..||.|..             | ||..| ..| .|.||. . || ....|. |.|||||.|||
ileeeqskelenalsGstavvallkkedlyvanvGDSravlcrngk...........avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGd

KEYK---EGEKKFCVSDPYQTTTDLTARDHFFILACDGLWDKVEYDEAVQFVQRNIKLGK--SATEISELLAQDSYDR-GSGDNITVLVV
...|   ...... ...|  ....||  | |.|||.||||| .. .|.|..|.. .. ||  ...|..|||..  ..| || |||||.||
hflkknkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_PPM1G_pd Subfamily PPM1G 699-794 2.6e-15 49.4 In-house 15-99 (473) alignment 
Range on Protein: 699-794
Range on HMM: 15-99/473.0
SKIKLESGFGSLQGRRKNMEDTHVILNNLmgavtyngppkDIPISYYAVYDGHGGTETSTLLEPTVHNCLVNSQSFRDGDYEQAFRDAYAEADDIV
|. .|. |... || |...||.|  . .|           |  .| .||||||||.| ..    .. ..| .......|| |.|...|. . |. .
sneelsygasamqGwrvsqEDahncitdl...........dedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDekl
0034914 PP2C-like 700-973 4.2e-62 202.6 In-house 18-291 (295) alignment 
Range on Protein: 700-973
Range on HMM: 18-291/295.0
KIKLESGFGSLQGRRKNMEDTHVILNNLMGAVTYngppkdipISYYAVYDGHGGTETSTLLEPTVHNCLVN-------SQSFRDGDYEQAFRDAYAEADD
. .| .|. | |||||..|| .... ||.   .         .....|.||||| ... ..  .... |..       . .. . |.|.|.|.|. .|| 
llllrvgvasdqGrrksneDavlvvlnllslled........lllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaade

IVIEKCEK------SGSTGVSALLVGNKLYTANVGDSEIVLARAQpnanpkgpvtyEPVLLSYKHLASDDQEKKRVTDLGGMIIFNRLFGSLAVSRSFGD
 ..|....      ||.| | ||..|||||.|||||| .|| | .           |.| |.. |  ..  |..|. ..||.....|..|.|||.|..||
ellelallrpelagsGtTavvalirgnklyvanvGDSravllrng...........elvqltvdhkpvnelererilsaggavshgrvngvlavtRalGd

KEYK-----EGEKKFCVSDPYQTTTDLT-ARDHFFILACDGLWDKVEYDEAVQFVQRNIKLGKSATEISELLAQDSYDRGSGDNITVLVVILN
 ..|       .. . .. |. |...||   |.|..||.||||| ....|.|..|..... |....|..| |.. ...||| |||||.|| ||
fdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrln
subfamily_PPM1A_pd Subfamily PPM1A 700-974 9.4e-57 185.5 In-house 9-282 (282) alignment 
Range on Protein: 700-974
Range on HMM: 9-282/282.0
KIKLESGFGSLQGRRKNMEDTHVILNNLMgAVTyNgppkdipISYYAVYDGHGGTETSTLLEPTVHNCLVNSQSFR--------DGDYEQAFRDAYAEAD
...|  |  | ||.|..|||.|..  .|  |.. .        |..||.|||.|.| ..  . .... ........        . ....|.|... ..|
gnglrygvssmqgwrvemEDahtvvaslg.alk.d.......wsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLald

DIVI------EKCEKSGSTGVSALLVGNKLYTANVGDSEIVLARAQpnanpkgpvtyEPVLLSYKHLASDDQEKKRVTDLGGMIIFNRLFGSLAVSRSFG
. .       ....||||| |..|.  ..|..||.||| .||.| .           . . |.. | .|...||||... ||... .|. |.|||||..|
eairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrng...........kaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalG

DKEYKE-----GEKKFCVSDPYQTTTDLTARDHFFILACDGLWDKVEYDEAVQFVQRNIKLGKSATEISELLAQDSYDRGSGDNITVLVVILNW
|.||||      |..  ...|. |... .  |.|..|||||.|| .. .|.|..|..... .. ..|... | . .. .||.||..||||....
DyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfak
0049733 PP2C-like 702-972 4.4e-48 156.6 In-house 2-233 (235) alignment 
Range on Protein: 702-972
Range on HMM: 2-233/235.0
KLESGFGSLQGR-RKNMEDTHVIlnnlmgavtyngppkdiPISYYAVYDGHGGTETSTLLEPTVHNCLVNS-QSFRDGDYEQAFRDAYAEADDIVIEKCE
.|. |. | .|| ||..||....                  ....||.||||| . . ..  .....|..  ...   |.|.|.|.|. .|.. ..|...
rlsvgaasdigrvrkvneDavlv.................glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelal

K------SGSTGVSALLVGNKLYTANVGDSEIVLARAQpnanpkgpvtyEPVLLSYKHLASDDQEKKRVTDLGGMIifnRLFGSLAVSRSFGDKEYKege
.      .|.| | |||.|.|||.|||||| ..| | .           . | |.. |  ....|..|....||..   | .|.||..|..|| ..|   
aspelagmgtTavvalldggklyvanvGDsrayllrdg...........klvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...

kkfcvsdPYQTTTDLTARDhFFILACDGLWDKVEYDEAVQFVQRniklgKSATEISELLAQDSYDRGSGDNITVLVVIL
       |. |...|.. | |..||.||||| .. .|.|.....     ... |. | |..  ..||. |||||.|| |
.......pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_ILKAP_pd Subfamily ILKAP 702-971 2.6e-46 151.1 In-house 4-291 (293) alignment 
Range on Protein: 702-971
Range on HMM: 4-291/293.0
KLESGFGSLQGRRKNMEDTHVILNNLMGAVTYNGpPKDIPISYYAVYDGHGGTETSTLLEPTVHNCLVNSQ-----SFRDGDYEQAFRDAYAEADDIVIE
||.. ..  .| |..|.|.||||..|.  .. .   .   .|||||.|||.|. .|     ..|. ...       | .. .  ... |.... |.  ..
klkgayaerkGereemqdahviledldeqlrlek.slvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLk

KCE------KSGSTGVSALLVGNKLYTANVGDSEIVLARAQPNANPkgpvtYEPVLLSYKHLASDDQEKKRVTDLGGMIIFNRLFGSLAVSRSFGDKEYK
. .      | ||| .. | . | ||.||.|||  ||.| .....      .  | |.  | . . .|.||.   ||..  .|. | | |||| || ..|
laskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdk.....iasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfk

EGEkkfCVSDPYQTTTDLTARDHFFILACDGLWDKVEYDEAVQFVQRNIKLG-----------KSATEI-----SELLAQDSYDRGSGDNITVLVVI
.      .| |  .  .||  | | .|||||||. .. ||.|.|..  ..             ||..|.     .. ||...  |||.||.|||.| 
rlG...vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvk
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 703-972 5.7e-46 149.8 In-house 6-253 (255) alignment 
Range on Protein: 703-972
Range on HMM: 6-253/255.0
LESGFGSLQGRRKNMEDTHVILNNlmgavtYNGPPKDipiSYYAVYDGHGGTETSTLLEPTVHNCLVNSQSFRDGDYEQAFRDAYAEADDIVIEKCEKSG
.. ||  . |||  |||  ||  .      ... ...    |||..|||||.....    .... | .     . . ......|| | .  . |.    |
fkvgfsdmiGrrptmedelviyGs......frdksde...dyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserpkfiG

STGVSALLVGNKLYTANVGDSEIVLAraqpnanpkgPVTYEPVLLSYKHLASDDQEKKRVTDLGGMIIFN----RLFGSLAVSRSFGDKeYKEgekKFCV
.| .|.|....| | |||||| .||.                . ||. |  |...|.||...|||... .    |. | |||||..||  . |    | |
ttaasvliiedkvyianvGdsrvvlc..........qkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.fle...Pfvv

SDPYQT-TTDLTARDHFFILACDGLWDKVEYDEAVQFVQRNIklgkSATEISELLAQDSYDRGSGDNITVLVVIL
.||. . . . . .|.|.||||||.|| .  .|||. |        .. . .| |   .| .|| |||.|.|. |
pdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagis....dpekaaeklrdlayssGstdnisvivikl
PP2C Protein phosphatase 2C 705-965 2.9e-78 255.9 Pfam-A 3-255 (255) alignment 
Range on Protein: 705-965
Range on HMM: 3-255/255.0
SGFGSLQGRRKNMEDTHVILNNLMGAvtyngpPKDIPISYYAVYDGHGGTETSTLLEPTVHNCLVNSQSFRDG-DYEQAFRDAYAEADDIVIEK------
.|. .|||.||.|||.|..|.||.         ........||.|||||.|.... . .....| ...||... ..|.|.|...... | ....      
vgaselqgarksmedahialknleks......sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskante

CEKSGSTGVSALLVGNKLYTANVGDSEIVLARAQPNAnpkgpvtyepVLLSYKHLASDDQEKKRVTDLGGMII-FNRLFGSLAVSRSFGDKEYKEGEKKF
..||||| |.||..|.|||.||||||..||.|.. ..          . |...| .||..|..|....||... ..|..|||||||..||.|.|..|...
psksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeql

CVSDPYQTTTDLTARDHFFILACDGLWDKVEYDEAVQFVQRNIKLGKSATEISELLAQDSYDRGSGDNI
....|. |...|| .|.|.|||.|||||.....|||..|..... .||..|..| |......||| |||
vsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 705-965 2.9e-78 255.9 In-house 3-255 (255) alignment 
Range on Protein: 705-965
Range on HMM: 3-255/255.0
SGFGSLQGRRKNMEDTHVILNNLMGAvtyngpPKDIPISYYAVYDGHGGTETSTLLEPTVHNCLVNSQSFRDG-DYEQAFRDAYAEADDIVIEK------
.|. .|||.||.|||.|..|.||.         ........||.|||||.|.... . .....| ...||... ..|.|.|...... | ....      
vgaselqgarksmedahialknleks......sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskante

CEKSGSTGVSALLVGNKLYTANVGDSEIVLARAQPNAnpkgpvtyepVLLSYKHLASDDQEKKRVTDLGGMII-FNRLFGSLAVSRSFGDKEYKEGEKKF
..||||| |.||..|.|||.||||||..||.|.. ..          . |...| .||..|..|....||... ..|..|||||||..||.|.|..|...
psksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeql

CVSDPYQTTTDLTARDHFFILACDGLWDKVEYDEAVQFVQRNIKLGKSATEISELLAQDSYDRGSGDNI
....|. |...|| .|.|.|||.|||||.....|||..|..... .||..|..| |......||| |||
vsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 705-965 2.1e-73 239.9 In-house 3-259 (259) alignment 
Range on Protein: 705-965
Range on HMM: 3-259/259.0
SGFGSLQGRRKNMEDTHVILNNLMGAvtyngpPKDIPISYYAVYDGHGGTETSTLLEPTVHNCLVNSQSFRDG-DYEQAFRDAYAE-ADDIVIEK-----
.|. . ||.||.|||.|..|.||.         ........||.|||||.|.... . .....| ...||... ..|.|.|..... . |.....     
ggasafqgfrksmedahialanless......sgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseant

-CEKSGSTGVSALLVGNKLYTANVGDSEIVLARAQPNAnpkgpvtyepVLLSYKHLASDDQEKKRVTDLGGMII---FNRLFGSLAVSRSFGDKEYKEGE
 ...|||| |.||..|.|||.||||||..||.| . ..          . |...| .|. .|..|....||...   ..|..|.|||||.|||.|.|..|
epstsGstAvvalitgsklyvAnvGDSravLcrsgnav..........kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpke

--KKFCVSDPYQTTTDLTARDHFFILACDGLWDKVEYDEAVQFVQRNIKLGkSATEISELLAQDSYDRGSGDNI
  .. ....|. ..|.....|.|.|||.|||||.|...|||..|..... . ...|..| |......||| |||
teeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
subfamily_PPM1G2_pd Subfamily PPM1G2 705-973 7.4e-50 162.5 In-house 21-287 (287) alignment 
Range on Protein: 705-973
Range on HMM: 21-287/287.0
SGFGSLQGRRKNMEDTHVILNNLMGAvtyngpPKDIPISYYAVYDGHGGTETSTLLEPTVHNCLVNSQSFRDGDYEQAFRDAYAEADDIVIEK----CEK
 |  ..|| | ||||.|.. |.|.        . |  ....||.|||||.. .      ... ... .||..|  ||...||. | |  ....     |.
vgssamqGyrlnmeDahilenellek......sddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkdes

SGSTGVSALLVGNKLYTANVGDSEIVLARAQPnANPkgpvtyepvlLSYKHLASDDQEKKRVTDLGGMIIFNRLFGSLAVSRSFGDKEYKEGE-----KK
.||| |..|.  .||| ||.|||  ||. .   ..           ||. |  .. .||||... ||.. .||  |.||.||..|| |.|...      .
aGstavvvlikeeklyvanaGDsravlsskgn.vka..........lsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeq

FCVSDPYQTTTDLTARDHFFILACDGLWDKVEYDEAVQFVQRNIKLGKSATEISELLAQDSYDRGSG------DNITVLVVILN
     |  ....|. .| | .|||||.|| .. .| |..|. ... |..  ||.| | ...  . |       ||.||..|.|.
ivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvll
PPM_PTC7_SpoIIE 705-963 4.8e-41 134.0 In-house 3-228 (230) alignment 
Range on Protein: 705-963
Range on HMM: 3-228/230.0
SGFGSLQGRRKNMEDTHVILNNLMGAvtyngpPKDIPISYYAVYDGHGGTEtsTLLEPTVHNCLVNSQsFRDGD-YEQAFRDAYAEA-DDIVIEkCEKSG
.|. . ||.||.|||.|....|..        ...    .....||||| .  .|   .....| .   |....  |...|...... .|.  | ...||
ggasaaqgarksmedahispanseks......sggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede.psssg

STGVSALLVGNK--LYTANVGDSEIVLARAQPNanpkgpvtyepvllsykhlasddqEKKRVtDLGGMI-I---FNRLFGSLAVSRSFGDKEYKEgEKKF
.| | ||. ...  ||.||.||| ..| |...                         |..|. ..||.. .   ..| ||.||||...||. ..  . . 
aTavvalidpstgklyvanaGdsppllvrddgg........................ereri.vagglpslGilpgrvfgvlavslapGdlllly.tDGv

CVSDPYqTTTDLTAR-DHFFILACDGLWDKVEYDEAVQFVQRNIKLGksateISELLAQDSYDRGSGD
  . |. | .... . |.| |||.|||||... .|.|..|.....       ..| |..|    .. .
veaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDitllvvr
subfamily_PPM1K_pd Subfamily PPM1K 706-972 2.2e-20 65.9 In-house 7-258 (263) alignment 
Range on Protein: 706-972
Range on HMM: 7-258/263.0
GFGSLQGRRKNMEDTHVIlNNLMGAvtyngppkdipISYYAVYDGHGGTETSTLLEPTVHNCLVNSQsFRDGDYEQAFRDAYAEADDIVIE---------
|. ||.|.|.. ||   . ..|              . |.||.|||.|. .       ....| .    .. | |. ...|. | |. .           
GkdsliGkraenedrikl.keldpe...........llyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaea

KCEKSGSTGVSALL-VGNKLYTANVGDSEIVLARaqpnanpKGpvtyEPVLLSYKHLASDDQEKKRVTDLGGMIIFNR-----LFGSLAVSRSFGDKEYK
. ..||.|   .||  |..|  |..|||  .| |       .|    ..  |.  |  . ..||.|.   ||.. .|      . | ||..||.|| . |
ellssGttatvsllrdGtelvlaslGdsrailcr.......nG....kakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlk

EgekKFCVSDPYQTTTDL-TARDHFFILACDGLWDKVEYDEAVQFVQRNiklgKSATEISELLAQDSYDRGSGDNITVLVVIL
.      ...|   . ..  |.| |..|  ||. . |.  |  ..|.      .   | .. |.. . . || || |..|| |
r...yGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlc....hdpeeaahalteqalqygsednatavvvpl
subfamily_PPM1L_pd Subfamily PPM1L 707-972 7.4e-38 123.3 In-house 9-266 (269) alignment 
Range on Protein: 707-972
Range on HMM: 9-266/269.0
FGSLQGRRKNMEDTHVILNNLMGAVTyngppkdipISYYAVYDGHGGTETS----TLLEPTVHNCLVNSQSF--R--DGDYEQAFRDAYAEADDIVIEKC
  |..|||..|||   | ...   ..         .|..||.|||||  ..     .|  ...| |.. ..   .    .... . |    .|  ..|| 
vysvlGrrprmedrfeieediknktg.........esffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdeklleka

E----KSGSTGVSALLVGNKLYTANVGDSEIVLARAQPNANPkgpvtyepvlLSYKHLASDDQEKKRVTDLGGMIIFN---RLFGSLAVSRSFGDKEYKe
.     .|.| . ||. ...|  ||||||  ||   . .| |          ||. |   . .|.||. . ||.| |.   |. | ||.||..||   | 
kraediaGttalialvqesdlivanvGdsrGvlydkrGkaip..........lsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.

gEKKFCVSDPYQTTTDLTA-RDHFFILACDGLWDKVEYDEAVQFVQRNIKLGKSAteiSELLAQDSYDRGSGDNITVLVVIL
 .|.. ..||   | ||   . .|.|||.|||||    .|||.|.. ..|  .     .  |. .|. ||| |||||||| |
.dknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfG...akslvlesfkrGsvdnitvlvvkl
subfamily_PPM1E_pd Subfamily PPM1E 709-973 5.6e-54 176.1 In-house 10-263 (265) alignment 
Range on Protein: 709-973
Range on HMM: 10-263/265.0
SLQGRRKNMEDTHVILNNLMGAVTYngpPKDIPISYYAVYDGHGGTETSTLLEPTVHNCLVNSQSFRDgDYEQAFRDAYAEADDIVIEK----CEKSGST
.....|. ||| ||.|..|   .      .. .....||.|||||.|...     .|. ||. ... . | ..|...|. ..|. ...|    . |||||
avknkrrkmEDrhvaledlnelfel...kdekeraffavfDGHgGveaakyaaahlhellvrqeklke.dpaealkeafkltDerflqkaereklksGst

GVSALLVGNKLYTANVGDSEIVLARAQpnanpkgpvtyEPVLLSYKHLASDDQEKKRVTDLGGMIIF---NRLFGSLAVSRSFGDKEYkegeKKFCVSDP
.|..|. ...|| | .|||. .| | .           | | |   |  ....||||. ..||....    |  |.|.|||. ||...    |.. ....
avvvliekdqlyvaWlGDsqallvrkg...........eavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvkl....kpyvsgea

YQTTTDLTARDHFFILACDGLWDKVEYDEAVQFVQRNIKLGK-SATEISELLAQDSYDRGSGDNITVLVVILN
  ....|.  ... ||||||||| |. .|.|. |.  .. |. . .|...|| . ....|| |||||.||.|.
dvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfld
subfamily_PPM1D_pd Subfamily PPM1D 710-870 3.9e-17 55.3 In-house 9-172 (309) alignment 
Range on Protein: 710-870
Range on HMM: 9-172/309.0
LQGRRKNMEDTHVILNNLMGAVTyngppkDIPISYYAVYDGHGGTETSTLLEPTVHNCLVNSQSFRDG---DYEQAFRDAYAEADDIVIEKCEK------
 || || |||. .|  .     .      ..  .. ||.||||| | ..     . . . . . |      |  .| |.|. .    . .| |.      
dqGgrkymeDvvaivleeeesae......elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktks

-----SGSTGVSALLVGNKLYTANVGDSEIVLARAQPnanpkGPVTYEPVLLSYKHLASDDQEKKRVTDLGGMII
     .|.|    .. ..|||.|.||||.|||.  .|     .  . ..  |   |  .. .||.|. .||| . 
gllstaGttasvviirreklyvahvGDsaivlgvkep.....kekklrakeltkdHkPespeekerieelGGeva
subfamily_KAPP-like_pd Subfamily KAPP-like 741-972 1.3e-19 63.3 In-house 33-266 (266) alignment 
Range on Protein: 741-972
Range on HMM: 33-266/266.0
PISYYAVYDGHGGTET----STLLEPTVHNcLVNSQSFRDG-----DYEQAFRDAYAEADDiVIEKCEKSGSTGVSALLV--GNK--LYTANVGDSEIVL
 |. .||.||| |  .    . |..  ... |..|    ||     |  . ...|. | |   ... |  |.|   ||.   |..  | .||||||   |
nialfavfdGhaGkGaadaakklfpkelek.llkstkqddGGdniydqskllenafkevda.klkdfeyeGatatlalvwsdGqqrylqvanvGdssafl

ARAQpnanpkgpvtyEPVLLSYKHLASDDQEKKRVTDLGGMIIFNRL-FGSLAVSRSFGDKEYKEGEKKFcVSDPYQT-TTDLTARDHFFILACDGLWDK
.| .           | . ||. | | |..||.|. | |  .  |.     |||||..||.  || .  . .|.|| .    ||  |.| |.| ||||| 
srGn...........eslelskdhkakdpeekqrikddGitlsdnqtrinGlavsralGdhfikelniGl.isepyvsnrilltpfdkflivasdGlwdv

VEYDEAVQFVQRNIKLGKSATEISELLAQDSYD-RGSGDNITVLVVIL
.. ..|.. |.     .... .... | . . .   . ||..|.|| |
isGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 742-972 3.3e-17 55.2 In-house 33-276 (276) alignment 
Range on Protein: 742-972
Range on HMM: 33-276/276.0
ISYYAVYDGHGGTE---TSTLLEPTVHNCLVNSQS-----FRDG---DY--EQAFRDAYAEADDiVIEKCEKSGSTGVSALLVGNK----------LYTA
|. .||.||| |     ..  | | . . |..| .       ||    |  .. . |.. | |.  ... |  |.|   ||.  .           | .|
ialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevda.klkdfeyeGatatlalvwsdGeeqqqqqqrylqva

NVGDSEIVLARAQpnanpkgpvtyEPVLLSYKHLASDDQEKKRVTDLGGMIIFNRL-FGSLAVSRSFGDKEYKEGEKKFcVSDPYQT-TTDLTARDHFFI
|||||   |.| .           | . ||. | |.| .||.|. | |  .  |.     |||||..||.  || .  . .|.|| .    ||  |.| |
nvGdssaflsrGn...........eslelskdhkatdpeekqrikddGitlsdnqtrinGlavsralGdhfikelniGl.isepyvsnrilltpfdkfli

LACDGLWDKVEYDEAVQFVQRNIKLGKSATEISELLAQDSYD-RGSGDNITVLVVIL
.| ||||| .. ..|.. |.     .... .... | . . .   . ||..|.|| |
vasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 743-875 1.7e-12 40.5 In-house 21-154 (292) alignment 
Range on Protein: 743-875
Range on HMM: 21-154/292.0
SY-YAVYDGHG--GTETSTLLEPTVHNCLVNSQSFRD----GDYEQAFrDAYAEADDIVIEKCEKSGSTGVSALLVGN-KLYTANVGDSEIVLARAQpna
..  ||.||||  | . . | | |.   |...             .   |  |. |.  |.. |..... | |    . .|. ||||||. .| |.    
tflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllril.diaakldkltidaresattavvcarvrddralilanvGdsrallgrcl...

npkGPVTYEPVLLSYKHLASDDQEKKRVTDLGGMIIFNRLF
   |   ||.. || .|  .| .|..|.   || .   |. 
...ggsdyeliPlsrdhkPedPderarilraGGrveptrvr
PP2C_SIG_SM00331 745-970 1.2e-09 31.0 In-house 33-215 (217) alignment 
Range on Protein: 745-970
Range on HMM: 33-215/217.0
YAVYDGHG----GTETSTLLEPTVHNCLVNSqsfrdgdyeQAFRDAYAEADDIVIEK--CEKSGSTGVSALL--VGNKLYTANVGDSEIVLARaqpNANP
..| ||.|    . . |  | . ... | .          ... .|  .... . |.  .. .. | . ||.   ..||. ||.||| ..| |   ... 
lvvaDgmGkGlaAaaassqlrtalrellseg.........eelsqalkrlnraiyeekeekgmfaTlllalydfssgklsyanaGdsrpyllr...dgkl

KGPVTYepvllsykhlasddqekkrvtdlggmiI-----------FnrlfgslavsrsfgdkeykegekkfcvsdPYQTTTDLTArDHFFILACDGLWDK
. ...                            .                                         .......| . . ...|. |||...
veilkd...........................vegaplGlepevs.............................vdirelelek.gdllllytDGltea

VEY-----DEAVQFVQRNIklGKSATEISE----LLAQDSYDRGSGDNITVLVV
..      ..  .... .   . .| |...     | . . ...  |.|||.||
rsekgfaeerleeiledlv..dseaqelaqkiveellelakgsngeDdiTvvvv
Subfamily Dicty-PPM1L-like 782-973 7.3e-16 50.9 In-house 88-304 (305) alignment 
Range on Protein: 782-973
Range on HMM: 88-304/305.0
AFRDAYAEADDIVIEKCEKSGS---TGV-----SALLVGNKLYTANVGDSEIVLA---RAQPNAN---PKGPVTYEPVLLSYKHLAS----DDQEKKRVT
| ..|. ..|    . .|  .    | .     |  |  ... ... .|.| ||.    |.. .    |||     |  . ..||       |... |. 
aiksaslstdkssldsaesdnkkaGttlngssasvilerertivstasdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririe

DLGGMIIFNRLF---GSLAVSRSFGDKEYKEgekkFCVSDPYQTTTDLT-ARDHFFILACDGLWDKVEYDEAVQFVQRNIKLGKSAT-------EISELL
 |.. ..    .   . | .||| |||. ||    . . .. .    .. | | |..|| ||||. ..|.. |..|.. ..  .|         |||.. 
slqaalynygellvnrllkksrskGdknlke....lviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrvi

AQDSYDRGSGDNITVLVVILN
.. .. ||||||||.... |.
veeavkrgsgDnitlviiklk
subfamily_PDP_pd Subfamily PDP 794-948 4e-17 55.4 In-house 143-321 (398) alignment 
Range on Protein: 794-948
Range on HMM: 143-321/398.0
VI--EKCEKSGSTGVSALLVGNKLYTANVGDSEIVLARAQPNANpkgpvtYEPVLLSYKHLASDDQEKKRVTDL------GGMIIFNRLFGSLAVSRSFG
..   .   ||.. . ||. |..|. ||.||.  ||.. .....      .| | ||  . |.  .| .|.           .|  .|| |.|. .| ||
lreallvalsGacallaliegtelhvAntGDcravlgvqeeegs......weavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFG

DKEYKEGE---KKFCV-------------SDPYQTT------TDLTARDHFFILACDGLWDKVEYDEAVQFVQRNIKLGKSATEI
| .||  |   ||                . || |.        |. .|.|..|| ||||| .. .|.|. |.. ..  |.....
dvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv
subfamily_PPM1G_pd Subfamily PPM1G 798-972 2e-28 92.6 In-house 293-470 (473) alignment 
Range on Protein: 798-972
Range on HMM: 293-470/473.0
CEKSGSTGVSALLVGNKLYTANVGDSEIVLARAqpnanpkgpvtYEPVLLSYKHLASDDQEKKRVTDLGGMII-FNRLFGSLAVSRSFGDKEYKEGE---
 |.||.| | ||| ..||. ||.|||  ||.|.            . . ||. |   |..|..|.   || .    |. | | .|| .||  ||. |   
GedsGttAvvaLlkekklivAnaGDsRcvlsrn...........GkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLp

--KKFCVSDPYQTTTDLTARDHFFILACDGLWDKVEYDEAVQFVQRNIKLGK--SATE-ISEL----LAQDSYDRGSG-DNITVLVVIL
   .     |   .. ||  |.|..|||||.|. .| .| |.||. ..| |.  . .| . ||    ||.|  . |.| || ||..|.|
lkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
subfamily_PP2D1_pd Subfamily PP2D1 800-946 2e-10 33.0 In-house 176-313 (492) alignment 
Range on Protein: 800-946
Range on HMM: 176-313/492.0
KSGSTGVSaLLVGNKLYTANVGDSEIVLARAqPNAnpkgpvtyepVLLSYKHLASDDQEKKRVTDLGGMIIFN----RLFGSLAVSRSFGDKEYKEgEKK
.| .. |  | .   || ||.|. . || |.  .|          . |  .|   . .|..||.  |. .  .    .  | | . |  |     .  ||
esngsevh.leelgvlyianaGnvqAvLcre.Gka..........iiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpk.Lkk

FCVSDPYQTTTDLTARDHFFILACDGLWDKVEYDEAVQFVQRNIKLGKSAT
  . .|. |.. |. .. | .||  |||. .. .| .. |.  ... || .
svipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrv
subfamily_TAB1_pd Subfamily TAB1 800-895 7.2e-09 27.9 In-house 128-218 (333) alignment 
Range on Protein: 800-895
Range on HMM: 128-218/333.0
KSGSTGVSALLVGNKLYTANVGDSEIVLARAQPnanpkgpvTYEPVLLSYKHLASDDQEKKRVTDLG---GMIIFNRLFGSLAVSRSFGDKEYKEGEKK
. |.| | ||.. |||| ||||||  .| . ..        . . . ||  |    ..| .|. |||     |  |...||    || || . |.| | 
sgGttAvvalifnnkLyVaNvGdsrAllvkrke........sekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykd
subfamily_PHLPP_pd Subfamily PHLPP 814-972 4.6e-09 28.5 In-house 106-245 (246) alignment 
Range on Protein: 814-972
Range on HMM: 106-245/246.0
KLYTANVGDSEIVLARAQpnanpkgpvtyEPVLLSYKHLASDDqEKKRVTDLGGMIIF-NRLFGSLAVSRSFGDKEYkegeKKFCVSDPYQTTTDLTARD
.|  |.||  . ||.| .           ... || ..  ..| | ||. .  ..|   |.. | .. .| .|          . . .|    . ||  |
sLevAsvGtlqavliRng...........kklrlsksyviekd.elkrikeakaiitednkingviestrllGytfl....fPvvlPkphvrevlLteqd

HFFILACDGLWDKVEYDEAVQFVQRNIKLGKSATEISELLaQdSYDrgSGDNITVLVVIL
 ..|.  . ||. ...||||. |... .    |  . .|. | ||.   .|...|||| |
ellivGnkalWevlsideaveavrkeedplvaAkklvdla.q.syg..aadsvsvlvvrl
subfamily_PPM1H_pd Subfamily PPM1H 872-940 3.7e-08 25.5 In-house 275-352 (404) alignment 
Range on Protein: 872-940
Range on HMM: 275-352/404.0
NRLFGSLAVSRSFGDKEYKEGE-----KKFCVSDPYQTTTDLTA----RDHFFILACDGLWDKVEYDEAVQFVQRNIK
.||.. ..|.| .|| | |  .     | |  . |  ...|||     .|.  ||| |||||... .|. . |.. ..
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevls
subfamily_PPM1D_pd Subfamily PPM1D 878-973 2e-10 33.3 In-house 201-308 (309) alignment 
Range on Protein: 878-973
Range on HMM: 201-308/309.0
LAVSRSFGDK-EYKEGEKKFCVS-DPYQTTTDLTARDH-FFILACDGLWDKVEYDEAVQFVQRNIKLGKSA----TEISELLAQDSYDRGSG-----DNI
|||.|| ||   |..  ..| || .|. . . |.  .. | ||| ||||. .. ..||..|... . ..      ..... | . . .| .      ||.
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnv

TVLVVILN
.|.||||.
svivvile
PPM_PTC7_SpoIIE_motif 913-970 3.7e-08 26.9 In-house 13-78 (81) alignment 
Range on Protein: 913-970
Range on HMM: 13-78/81.0
HFFILACDGLW-------DKVEYDEAVQFVQRNikLGKSATEISELLAQDSYDRG---SGDNITVLVV
  ..|..|||.       . .. .|......|.   |||. |... | ..   .|   . |.||.||.
dvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevlengsgereDDitllvl
PPM_PTC7_motif 916-965 4.8e-17 55.2 In-house 1-51 (51) alignment 
Range on Protein: 916-965
Range on HMM: 1-51/51.0
ILACDGLWDKVEYDEAVQFVQRNIKL-GKSATEISELLAQDSYDRGSGDNI
|||.|||||.....|||..|.....  |.| .|..| |....  ||| |||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni