Gene Aph-4 in Drosophila melanogaster

Synonym: AP, Aph, CG1462, Dmel\CG1462, aph-4, l(3)07028, pMY51, Dmel_CG1462, Aph-4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP001_AA protein Get Run
DmelP001_AA_74-545 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_AP_pd Subfamily AP 54-544 1.3e-182 598.3 In-house 3-470 (472) alignment 
Range on Protein: 54-544
Range on HMM: 3-470/472.0
AEFWHNVGLRQLEKTIKQAqrvkedSYQKKARNIIIFIGDGMGISTISAGRIYKGQyLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFS
|.||.. . ..|.. ...       | .|||.|.|.|.|||||.||..|.||.||| ||...|||..| ...||..|..|||..||||||||.||||...
akfwlkkaqeelkealelq......snskkakNvilflgdGmgvstvtaaRilkgq.lkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylc

GSKTHYGAIGMDATRSKKNGQ---QGRVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAESV-GFHVDIARQLVENAPGNRFNV
| ||..|.||.||....|...   . .|.|..|.|.|.||.||.|||||.|||.||..|||. .|.||.|.|||||.    ..|||.||.|...|....|
GvktnngtiGvdaaverkdCeasagkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeaekegckdiaqQLieeevgkeldv

ILGGGmspMGILNASEVKTTIFEGPtetiCTRGDNRNLPAEWlahhANDTVPPALVHNRKDLLNVNVKKVDHLMGLFRNNHITYSIAR-EAGEPSLQEMT
|||||   .  .  ..||..  |      ..| |.||| .||    ....   ..|.|||.|.||...|.|.|.|||...|..|.|.| |..||||.|||
ilGGG...rkkflpktvkdseyekk....gerkDgrnLieew....ekekknakyvenrkelenvdksktdrllGlfadshlkyeidrdekeePsLkemt

ETALGILERgdESNGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALRGADILGTANSHEKNDPMFYE
|.|| .|..  ..|||.|.|||||||..||.| |..||.|..||| |...|.. ||...|||.|||||||..|..||. ||..|||.|......| . |.
ekAlevLsk..nenGffLfVEggrIDhahhenkakkaleetlefdeavelaleltdeedTlivvtaDHshtltiagypkrgssilglakesksadelpyt

TISYANGPGYWDHLANDSRpQNSSNMwmplkhfTAEERAAPTYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAK
|.||||||||... .. .. ......       |. |..|..|.. |.|| ..||||||||||.|.|| |.|..||.||...|.||.|| |||.|.
tlsyangpgyeltesdlee.gerkdl.......teaeteakdyvsqaavpleeetHggeDvavyasGpqshlltGvveqstiahvmayaaclgeae
0037220 Alkaline phosphatase-like 75-545 5.6e-139 454.0 In-house 24-473 (479) alignment 
Range on Protein: 75-545
Range on HMM: 24-473/479.0
VKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQyLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATRSKKNGQ
..    ..||.|.|.|||||||.||..| |||.|| |..|.|||..|..|.|| .|..|||.||..|.|||..|||...| ||..||||.||..| .| .
lllllnkskaknvilfigDGmgvstvtaariylgq.llgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlatGvKtnngaigvdadvsrdncd

QGR---VQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAESVGF-HVDIARQLVenaPGNRFNVILGGGMSPmgiLNASEVKTTI
. .   |....|.|.. ||.||.|||||||||||||.|||...|.||.|..... ...  . |||.|||   .|....||||||..    . ....... 
dplgnpvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleagckdiatqlv...lgsgldvilGGGrky...flpkgtldpe

FEGPTETICTRGDNRNLPAEWLAHHANdtvpPALVHNRKDLLNVNV-KKVDHLMGLFRNNHITYSIAR-EAGEPSLQEMTETALGILERgdESNGFVLLV
 .  . . ..| |.|.| .|. .....     ..|.||..|..... ..||.|.||| ..|. | . |  ..|||| ||||.|| .|..   ..||.|.|
ydlelllggkrldgrdlleeakekkkg....ytyvtnreeldaldlgsnvdkllGlfadshlpyeldrdaseePsLaemtekAldlLsk..ndkGFfLmv

EGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALRGADILGTANSHeKNDPMFYETISYANGPGYWDHLANDSRP
|||||| ..| | |.|||.|...|| |..||.. ...|.||..|||||||.....||| || .|||....  . |.. | |..||||||.. .| .   .
EggriDhagHandaaaalgevlafdeaveaalefakdddTlvvvtADHshgglilgyadrgnpilgllpgl.lldglpyttllyangpgflllldlrldl

qnssnmwmplkhfTAEERAAPTYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKD
             |     |..... |.|.  ...|.||||.|.|||||..|..||.|....|.|. .| .||... 
.............tllvtlallllqralvgwtsggHtgedVpvyayGpgaelflgvyentdiahviasalglgllev
Alk_phosphatase Alkaline phosphatase 84-540 4.8e-128 418.2 Pfam-A 1-421 (421) alignment 
Range on Protein: 84-540
Range on HMM: 1-421/421.0
ARNIIIFIGDGMGISTISAGRIYKGQylKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDatrskknGQQGRVQSVME
|.|.|..|||||| ||..| |..|.|  ..|   ||.| .| .| .|..|||.|||||.|||.||||  .| ||  ||||.|        .. .|.||.|
aknvilligDGmgvstvtaaRslkeq..akgklgeeilaldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd.......thgkevksvle

WAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVP-AESVGFHVDIARQLVENApgNRFNVILGGGMSPMGILNASEVkttifegpTETICTRG
.|.|.|| ||.|||||.|||||||..||  .|.|| |.... .   . . ||| ||....  ....|.|||| . .   . ..         ...  || 
aAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikak..kkidvllGGGrkeflptgtkde........ekerGtrl

DNRNLPAEWlahhanDTVPPALVHNRKDLLNVNVKK-VDHLMGLFRNNHITYSI-AREAGEPSLQEMTETALGILERGDesNGFVLLVEGGRIDQGHHMN
|.|||  |.            .|..||.||... .. |..|.||| .... ...  .|. ||||.||||.|. .|.. .  .|| |||||.|||...| |
dgrnlieea......kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLskne..kGFFLlVEGsrIDhaaHen

YARAALHELYEFDLAIQAAVNNT-DPDETLILVTADHSHAVTFNGYALRGADILGTANSHEKNDPMFYETISYANGPGYWDHLandsrpqnssnmwMPLK
.|  ||.|  ||| |..||.. .   .|||..|||||||.....||  ||..| |.|.. ...| . .. |.|.||.|.  .                 .
davgalsEvvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakved.............gare

HFTAEERAAPTYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCL
. |||| .. .||. . |. . |.|.||||||||||| ..|.||| ||...|.|. .| .|
nvtaeealekiyrkrsavgltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
Alk_phosphatase Alkaline phosphatase 84-540 4.8e-128 418.2 In-house 1-421 (421) alignment 
Range on Protein: 84-540
Range on HMM: 1-421/421.0
ARNIIIFIGDGMGISTISAGRIYKGQylKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDatrskknGQQGRVQSVME
|.|.|..|||||| ||..| |..|.|  ..|   ||.| .| .| .|..|||.|||||.|||.||||  .| ||  ||||.|        .. .|.||.|
aknvilligDGmgvstvtaaRslkeq..akgklgeeilaldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd.......thgkevksvle

WAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVP-AESVGFHVDIARQLVENApgNRFNVILGGGMSPMGILNASEVkttifegpTETICTRG
.|.|.|| ||.|||||.|||||||..||  .|.|| |.... .   . . ||| ||....  ....|.|||| . .   . ..         ...  || 
aAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikak..kkidvllGGGrkeflptgtkde........ekerGtrl

DNRNLPAEWlahhanDTVPPALVHNRKDLLNVNVKK-VDHLMGLFRNNHITYSI-AREAGEPSLQEMTETALGILERGDesNGFVLLVEGGRIDQGHHMN
|.|||  |.            .|..||.||... .. |..|.||| .... ...  .|. ||||.||||.|. .|.. .  .|| |||||.|||...| |
dgrnlieea......kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLskne..kGFFLlVEGsrIDhaaHen

YARAALHELYEFDLAIQAAVNNT-DPDETLILVTADHSHAVTFNGYALRGADILGTANSHEKNDPMFYETISYANGPGYWDHLandsrpqnssnmwMPLK
.|  ||.|  ||| |..||.. .   .|||..|||||||.....||  ||..| |.|.. ...| . .. |.|.||.|.  .                 .
davgalsEvvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakved.............gare

HFTAEERAAPTYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCL
. |||| .. .||. . |. . |.|.||||||||||| ..|.||| ||...|.|. .| .|
nvtaeealekiyrkrsavgltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
Metalloenzyme Metalloenzyme superfamily 257-424 1e-06 18.5 Pfam-A 66-202 (252) alignment 
Range on Protein: 257-424
Range on HMM: 66-202/252.0
PmgilnasevkttifegptetictrgdnrnlpaewL--AHHANDTVPPALVHNRKDLLNV-NVKKVDHLMGLFR------NNHITYSIAREAgepSLQEM
                                   |  ..  ..|    |..|    | . ...|. |.  .|       .. .||... |    | .|.
l..................................lrgpeelantpgefleknglkqlriaetekykhvtfffnGvlvispegaTydlkpem...sakei

TETALGILERGDESNGFVLLVEGGriDQGHHMNYaRAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNG
|...|  || |. .  .| |...   . ||  ..  |.   . ..| ...  ... . ...|...||||. | ....
tdkllealekgkydfvvvnlantD..mvGHtgdv.eakvkaieavDerlkelldavekeddlliitADHgnaeemkd