Gene flw in Drosophila melanogaster

Synonym: Dmel\CG11597, PP4, Dmel_CG11597, CG11597

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP086_AA protein Get Run
DmelP086_AA_154-434 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP5C_pd Subfamily PPP5C 130-419 1.8e-83 273.2 In-house 6-299 (322) alignment 
Range on Protein: 130-419
Range on HMM: 6-299/322.0
REEPKKSRLKLRDFFVAEFVRSCRTGKQVQMTeaEVRGLCLKSREIFLQQPILLELEAP----LIICGDIHGQYTDLLRLFEYGGFPPAA-NYLFLGDYV
 . ||  . |.   || |...  .  |...     .  . |...|.. ..| |.|.. .    | .|||||||. ||| .||  | |     ||| ||.|
ydgpkleeekitkefvkellelfkkqkklhkk..yalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfv

DRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGL-SPDLQGMEQIRRLMRPT
|||  |.|.| .||..|. ||..||| |||||  ..|..||| .|.| .|. |. . ||. || ||.| .|.||.. .|||| | |   ....|.. | .
drGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrna

DVPDTGLLCDLLWSDPDKdVQGWGENDRGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTV-DDTL
. |. |||..||||||..  .| ..  |||...|| || .|||.  .|.|| |.|.| |.|||.    .|.|.||||||| . .| |...|. .| |
qppeegllvellwsdpqe.anGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddl
subfamily_PPP1C_pd Subfamily PPP1C 152-431 9.3e-161 526.6 In-house 2-281 (282) alignment 
Range on Protein: 152-431
Range on HMM: 2-281/282.0
CRTGKQVQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
...||.|...|||.. |. |.|||.|.||||||||||. |.|||||||.|||||||..|.||..|||||||||||||||||||.||||||||||||.|||
skkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfll

RGNHECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDR
|||||.|||||||||||||||||..||||||||.|||||.||..||||.|.||||||.|. .||||...||..||..|||||||||||||.|.||.||||
rGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPSEK
||||||| |||.|||....||||.||||||||||||||.|||||.||||||||||||||....||..|..|||||||..|
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_PPZ_pd Subfamily PPZ 153-431 1.2e-133 438.3 In-house 18-296 (300) alignment 
Range on Protein: 153-431
Range on HMM: 18-296/300.0
RTGKQVQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLR
.  |.| . ..|.  .| |.||.|| || ||||  .. | ||.||||.||||||   ||||.|||||||||||||||||||| |||.|||||||||||||
krtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllr

GNHECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRG
|||||| . |.|||||||||| |.|.|||| | || ||.|||.  |||| |||||| |. |..||...||||||| ||. |||||||    . | .|.||
gnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednerg

VSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPSEK
||. .    . ||||.  .||.|||| |||||||||  | |||.|||||||||||| | .|.| . |.|||..| | . 
vsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds
0045823 Metallo-dependent phosphatases 155-433 2.8e-118 388.5 In-house 38-328 (473) alignment 
Range on Protein: 155-433
Range on HMM: 38-328/473.0
GKQVQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGN
 |. ...| ... |. . .||. ..| ||||.......||||||..|||||.|  ||||. ...||||.|||| .|||...||||.|||||.|.||||||
kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGN

HECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPdKDVQG--------W
||.. .| .|||.||. ..|...|.. | .....||.||.|..||...||||||||. ..|||.. || ..|| |||.|||||||  .. |        .
HElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlrff

GENDRGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQ------LVTLFSAPNYCGEFDNAGGMMTVDDTLmCSFQILKPSEKKA
| . ||....|| |.| .||... ||||.|.|..|..|||.. ...      ..|.||||||||...| ......|..| .||....||. . 
gnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphpl
0049330 Metallo-dependent phosphatases 155-434 1.8e-114 374.9 In-house 25-304 (309) alignment 
Range on Protein: 155-434
Range on HMM: 25-304/309.0
GKQVQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGN
 |.....| |.. |.|| .||....|.||||.......||||||..|||||.|  ||||. ...||||.|||| .|||...||||.|..||.|.||||||
lklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGN

HECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVS
||.. .|..|||.||..|.|...||. |.|....||.||.|..||.|.||||||||. ..|||.|.||...|..|||||||||||. .. |...|.||..
HElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprglg

FTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPSEKKAK
..|| ..| .||... ||||.|.|..|..||..|. ..|.|.||||||||...|.|.....|..|..||....|.. . .
vvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 156-432 1.4e-135 444.1 In-house 19-297 (298) alignment 
Range on Protein: 156-432
Range on HMM: 19-297/298.0
KQ-VQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGN
|   ...|..|  |. ....|| .|. |.|..||. .||||||||.||||||. .|||| |||||||||||||.|.||.|.||||||.|||.||||||||
kltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGn

HECASINRIYGFYDECKRRY-NVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGV
|||..|||.||||.|||||| ...|...| | || ||..|.| ..|.| |||||. |. ..|.|.| ||.| ... |  ||||.||.. |.|| || |||
heceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGv

SFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPSEKK
|..|| ||| ..|.. ..||..|||||| ||||||| ..|||.||||.|||.|||. ..|.||. |..||..|||..|.
svvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
0053225 Metallo-dependent phosphatases 156-429 1.9e-105 345.3 In-house 18-291 (293) alignment 
Range on Protein: 156-429
Range on HMM: 18-291/293.0
KQVQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNH
......| |.. |.|. .||....|.||||.......|||||...|||.|.|. ||||. ...||||.|||| .|||...||||.|..||.|..||||||
llkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNH

ECASINRIYGFYDECKRRY-NVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDkDVQGWGENDRGVS
|.. .| .|||.||..|.| . .||. ..|....||.||.|..||...||||||||  ..|||...||...|..|||.|||||||| .. ||. . ||..
ElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrglg

FTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPS
..|| ..| .||... ||||.|.|||| |||...  ..|||.||||||.|...|.|.....|. |...|....|.
vvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 156-428 1.1e-76 251.0 In-house 16-291 (307) alignment 
Range on Protein: 156-428
Range on HMM: 16-291/307.0
KQVQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNH
...| |  |.  .  ... ||  .  |.... | .. ||.|||. ||. .|   | || . |.| |||||||  |||.| ||..||| ||||  ||||||
hkiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnh

ECASINRIYGFYDECKR---RYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRG
| | .|. ||||.||     .   ..|  |  ||| ||..|.|  ||.| |||||| |  ....|   .|   |  |.. |.||.|||  |  |    ||
eiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrg

VSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKP
  |||| .|.    .|  ..|| ||||.. |||  .. |.|.|.|||| ||  . ||| .. ||.||      . |
sgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvp
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 157-430 6.6e-99 323.7 In-house 5-278 (281) alignment 
Range on Protein: 157-430
Range on HMM: 5-278/281.0
QVQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
.||.|. |.  .  . . || ..  | |...|  . ||.|.|..|| ||||  | .|   ..|||||||||.||||.. ||...||.|... .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFT
 ||.|.||||| ||. .| ..||  |  ||| ||..| |.... | ||||||.|  ....|   .| . .| ||. ||||.|||..|..| .  ||.|||
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPSE
|| .|| .   | |..|| |||||| |||| .. |.|.|.||.||||  . ||. ...||.||  |.. | |. 
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_PPP3C_pd Subfamily PPP3C 157-420 1e-87 287.8 In-house 38-314 (452) alignment 
Range on Protein: 157-420
Range on HMM: 38-314/452.0
QVQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
. ...|...  .  .. ... ... |||.|||....||||||. |||.||| || |  ..|||||||||||  |.|..  |.| ||.||...||||||||
egrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhe

CASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWG-------EN
|  .   . | .||| .|. .........|..||.||..... .|.||||||... ...|..| |  ..| .|.||||||||| .| .          ..
crhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpns

DRGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFAR------RQLVTLFSAPNYCGEFDNAGGMMTVDDTLM
 || |. ..   |..||.. .|  | |||.. ..||. . .        |.||||||||.. ..| . .. ...  |
vrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 157-428 2e-66 217.2 In-house 3-299 (302) alignment 
Range on Protein: 157-428
Range on HMM: 3-299/302.0
QVQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYG------------GFpPAANYLFLGDYVDRGKQSLETICLLLAYKIKY
. .... |.  |. .  | . ..  | |. .|. | ||||||. ||.|.. .             .|     ..|||||||||..|.| |||..|.|. |
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvly

PENFFLLRGNHECASINRIYGFYDECKRRY----NVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRP-TDVPDTGLLCDLLWSDP
|.|. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.| |||.|| |. .|.|... || ..| .  |  |||..||
ptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadp

dKDVQG---------WG-ENDRGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKP
  |||.         .  .. ||.|..|    | .. .| .|.|| ||||..  |. ||| ..|.|.||||.|  | || | .. ||     | ..|..
.ldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 157-427 3.9e-66 216.3 In-house 4-299 (302) alignment 
Range on Protein: 157-427
Range on HMM: 4-299/302.0
QVQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYG------------GFpPAANYLFLGDYVDRGKQSLETICLLLAYKIKY
. .... |.  |. .  | . ..  | |. .|. | ||||||. ||.|.. .             .|     ..|||||||||..|.| |||..|.|. |
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvly

PENFFLLRGNHECASINRIYGFYDECKRRY----NVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRP-TDVPDTGLLCDLLWSDP
|.|. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.| |||.|| |. .|.|... || ..| .  |  |||..||
ptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadp

dKDVQG---------WG-ENDRGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILK
  |||.         .  .. ||.|..|    | .. .| .|.|| ||||..  |. ||| ..|.|.||||.|  | || | .. ||     | ..|.
.ldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 158-428 5.5e-111 363.6 In-house 6-282 (284) alignment 
Range on Protein: 158-428
Range on HMM: 6-282/284.0
VQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFP------PAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
  ..| |.  ||...||.| .... ||.|||. |.||||||. ||| |..  |.|         .|||||||||||  |.| | ||.|||...|.. |||
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDR
|||||   .|. |||| |||.|| ..|...|  .||..|..|....||.| |||.| ||  ..|. .| ||.|.|| |...|| |.||...|.|. | .|
rgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykespr

GVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKP
|   .|| . | .||....|||. |||||| ||||||| |.|||.|||| |||..||.. ...||. |..||..|||
gagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_PPP2C_pd Subfamily PPP2C 158-432 3.1e-101 331.4 In-house 15-289 (290) alignment 
Range on Protein: 158-432
Range on HMM: 15-289/290.0
VQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHEC
 |..|.||. || | .||. ..  . |...|. .|||.|||. ||| ||  ||  | .||||||||||||  |.||..|| | |..|.|   .|||||| 
kqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhes

ASINRIYGFYDECKRRY-NVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDkDVQGWGENDRGVSFT
  | ..||||||| |.| | ..|| ||| |..||..|..||.||| |||||| .. ...|| | |  .||. | |||||||||| | .|||  .||  .|
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagyt

FGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPSEKK
|| |.  || .. .| || ||||.| .||..   |..||.|||||||    | .... .||.|  ||   .|. ..
fgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 159-434 2.2e-126 414.1 In-house 23-299 (299) alignment 
Range on Protein: 159-434
Range on HMM: 23-299/299.0
QMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 . | |.. ||  ....|..|. |||.|||.|.||||||||.||||.|.  |||| .|.||||||||||.| ||.|.|||..||||||.||.||||||| 
svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecp

SINRIYGFYDECKRRYN-VKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTF
.|||.||||.||..||.  .||  | |.|. .|.. .|  .|.| |||||| || ..|.| | || | |.  |  ||||.|||. |..|  | ||||. |
ainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvf

GVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPSEKKAK
| |||.. ..| ..||..||||||.||||||| ..|||.|||| |||.|||.  .| ||. |.|.|..|||..|..|
gqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpkslk
subfamily_PPP4C_pd Subfamily PPP4C 159-428 7.8e-103 336.6 In-house 15-284 (288) alignment 
Range on Protein: 159-428
Range on HMM: 15-284/288.0
QMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 ..| ||. || |.|||....  . ....| ..|||||||. |||.||. ||  |  |||||||.||||. |.||. ||||.|..||..  |.|||||. 
likeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesr

SINRIYGFYDECKRRY-NVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDkDVQGWGENDRGVSFTF
.| ..||||||| |.| ....|.  |. |. |..|||||.|||| ||||||... ...|| . | ..||. | |||||||||. |..||.   ||  . |
qitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylf

GVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKP
| |||..| .. ...|||||||.| .|| .  .....|..||||||    |   .. .|..|   |.|.. 
gsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifea
subfamily_PPP6C_pd Subfamily PPP6C 159-427 2e-92 302.4 In-house 14-282 (290) alignment 
Range on Protein: 159-427
Range on HMM: 14-282/290.0
QMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 ..|.... || .  ...|..  .  ...|. .|||||||. ||. ||  ||  | ..|.||||.||||  ||||. .||. |.|||..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRY-NVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPdKDVQGWGENDRGVSFTF
 | ..|||||||...| |.. || .|. |. |..||||||...| |||||||.. ..||| . | ...|  | .|||.|||| .||. |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagylf

GVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILK
|  |...|..  .|.|||||||.||.|....   .|||..||||||    |   .....|.   .....|
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 159-213 6.5e-17 54.7 In-house 8-62 (317) alignment 
Range on Protein: 159-213
Range on HMM: 8-62/317.0
QMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPP
 ..|.|.  ||...||.| ..|. ||||||. |.||||||. ||| |..  |.| 
lfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 160-431 8.2e-119 388.9 In-house 6-277 (280) alignment 
Range on Protein: 160-431
Range on HMM: 6-277/280.0
MTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
. ||.. ..  | ..|.. |  ..|..||. .|||.|||||||||||.  .|||  ||||||||||||.| || |.||||||..||.||..||||||..|
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

INRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGV
||| |||.||.||||. .|.. | . .. ||..|..  .|.| |||||..|. ......|.|| | .|  |  ||||.||...| ||.|| ||||  || 
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

DVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPSEK
.|| .. .. ..|||.| ||||.||||||| ..|||.||||.|.|||||. ... ||. |. ||..|||. .
nvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalr
PP2Ac_SM00156 160-429 3.9e-115 376.6 In-house 1-270 (271) alignment 
Range on Protein: 160-429
Range on HMM: 1-270/271.0
MTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
... ||. |. ...||. |.. |.|..||....||||||..|||||.| .|.||  .|.|||||||||.||.|.|.||.|.||.|||...|||||||. |
lskeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsss

INRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGV
.|.||||..|.||.|. .... |...|..||.||..|.||.| ||||||.|. ...||.| |. . |. |||.|||||||.....|.  . ||.|..|| 
vnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPS
|.|..||....|.||.|||.||..||||||...|||.|||||||.||.|.. ...|...|..|.. ||. 
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
PPP_3 160-427 1.7e-111 364.6 In-house 2-270 (271) alignment 
Range on Protein: 160-427
Range on HMM: 2-270/271.0
MTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
..| |.. |. | .||. ....|.|..||. .|||||||..|||.||..||..|  .||||||||||||.|||...||||.|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFG
||..|||..|.. .... |..|.....|..||.||.||||....||||||... ..||..| |...||..|.|.|||.|..... .|.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

VDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILK
 ||...||....|.||.|||...|.|||.......||.|||||||....||| .......|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 160-429 6.5e-105 343.6 In-house 23-295 (297) alignment 
Range on Protein: 160-429
Range on HMM: 23-295/297.0
MTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
.||  |  |   . ..| .|  ..|..||. .|||||||. ||||||  ||.||.|||||||||||||. |.||| ||||||.|.| |.|||||||||  
iteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

INRIYGFYDECKRRYN-VKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSP---DLQGMEQIRRLMRPTDVpDTGLLCDLLWSDPDKDVQGWGENDRGVSF
.|..||||.||..||. |... .| | || ||.. .| .||.| ||||||   .   .. .|.. |.|.    .|..||||.||   . |. ||.||   
vnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrgagc

TFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPS
 || | | |     .|||.|||||||.||||||| |.|||.|||| |||.|||.  .|..|. | |||.||.|.
gfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 160-429 1e-85 280.6 In-house 6-275 (280) alignment 
Range on Protein: 160-429
Range on HMM: 6-275/280.0
MTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
||  |.  .      ||...  | | |||. . |||| || |. |||.  |  |  . .||||||||| | .| . ||.. ||.| .  .|||||||  |
mtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetps

INRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGV
.|.||||| ||. .| | ||  |  ||| .|....| ....| ||||||.|  .. || . || .  | ||| ||||||| .  .||  . ||.|. || 
vnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgk

DVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPS
 || .  .  |.||| ||||||.||||..| |.|.|.|| |||| .| ||  .. ..  |  ||| | | 
gvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_PPG1_pd Subfamily PPG1 160-425 7.1e-84 274.6 In-house 14-292 (300) alignment 
Range on Protein: 160-425
Range on HMM: 14-292/300.0
MTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
. |. |. |. | .|.....  . |...|. . ||.|||. |.| .|. ||  | .||||||||||||  |.||| ||.. |..||    |||||||   
lpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrq

INRIYGFYDECKRRY--NVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPD---------KDVQG--W
| ..|||| || |.|  | ..|| .|. |. | .||||||.|.| ||||||. . ..||. | |  .||. | |.|||||||.          | .|  .
itqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhf

GENDRGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQI
 . .||  ...| ||| |||.  ... | ||||.. .||. .   .| |..||||||    |   .. . . .   |..
vvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 160-213 2.1e-12 39.8 In-house 11-64 (339) alignment 
Range on Protein: 160-213
Range on HMM: 11-64/339.0
MTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPP
.  ||.  || ..||.   .||.|.||||. . ||||||. ||| ...  |.| 
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpl
PPP_1 161-414 6.7e-112 366.1 In-house 2-263 (264) alignment 
Range on Protein: 161-414
Range on HMM: 2-263/264.0
TEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.|.|.. |. |..|.. ....|||..... .|||||||..|||.||..||..|  |||||||||||||.|.|...||||.|.|||...||||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECK-RRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLL-------WSDPDKDVQGWGENDRG
...|||..|.. ..|. ...||.||.|..||.||.|||||...||||||.|. ..|||...| |.||..| |||||       .||.... ... ...||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMT
....|| ||..|||....|.||.|||.|.|.||||...|..||.|||.||. |..|.| ...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 161-431 5e-94 307.4 In-house 11-284 (287) alignment 
Range on Protein: 161-431
Range on HMM: 11-284/287.0
TEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.. ..  .  | .||.   | |||.|||. |.||||||. ||||.|.  | .|  .||||||||||| .||| . ||...||.||..  |||||||.  |
sdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkki

NRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDT--GLLCDLLWSDPDKDVQGWGEND-RGVSFTF
|..|||..| ||... .|.|.| | |. ||. |.....|.| |||.||.|. ..... | .||   .   ||  ||||.||.|| ..   |  |..|  |
nklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvf

GVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPSEK
|  .| ..|.. ..||| |||.|.|.||.|.. ..|||.|||| |.||  | | ...|...|  ||  ||| . 
GkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 161-429 8.5e-83 270.7 In-house 17-289 (290) alignment 
Range on Protein: 161-429
Range on HMM: 17-289/290.0
TEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.. ..  .  | .||.   | |||.|||..| ||||||  .||| |.  |.||  ..|||||||||| .|||   ||. |||.|...  |||||||.  .
sdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkv

NRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTD--VPDTGLLCDLLWSDPDKDV-QGWG-ENDRGVSFT
||.|||..|  |. . .||| . | |. |.. | ...||.| |||.|....  | .. | .|      | ||  ||||.||..|  .    .  |..|  
nrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvv

FGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPS
|| ... ..|..  |.|| |||.| |.|..|   ..|||.|||| |.|.  | | ..|| ..|  |. .||| 
fgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 163-434 3.6e-109 357.6 In-house 6-279 (284) alignment 
Range on Protein: 163-434
Range on HMM: 6-279/284.0
AEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 .|  | ... .|| .||.|.| ..|. ||||||||..||||||.  |||  ||||||||||||||. |||| ||.|||. .|. ||.|||||||. ||.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

IYGFYDECKRRYNV-KLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTG-LLCDLLWSDPDKDVQGWGENDRGVSFTFGVD
|||||.||.||||   ....|   |  .|..|.. ..|.| |||.|  || . |.| . || | |.   |  |.||||| .  .||  | ||||. || |
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

VVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPSEKKAK
 . |.|.| ..||. ||||||.||||||| |.|||.|||| |||.||||  .| |.  |.||| .|.| .| |.
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiar
subfamily_PPPLV_pd Subfamily PPPLV 167-416 9.2e-58 188.8 In-house 4-276 (290) alignment 
Range on Protein: 167-416
Range on HMM: 4-276/290.0
GLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLL----RLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 || .. .|....  ||||..|  . ||.||.| ||      |.  |     |..||||||||||. |.| |. ||| |. ||  ..|||||||  |.  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRYNVKL---WKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIR------RLMrPTDVPDTGLLCDLLWSDPDKD-----------
 . .. |.. ..  .|   |..|...|. ||.||.||.|.||.|.|.    ..  .|         . . |.  . |  |.|||||..|           
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerl.kddidgaplaldilwsdpaedrdlslrgelvl

VQGWGEND-RGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGgMMTVD
 .|. .|| || .  |. | . .||.| .|. . |||.| | |...  . .|.|.||. .|||  ..|  .. ||
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaa.lilvd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 182-430 1.1e-71 234.6 In-house 2-257 (263) alignment 
Range on Protein: 182-430
Range on HMM: 2-257/263.0
LLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNV-----
||||.||. |||| |||| ||||.|.  |    ..||||||||||| .||| | ||.. |.  | ...|||||||  .||. |||. | |.|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDT-GLLCDLLWSDPDKDVQGWGEND-RGVSFTFGVDVVSKFLNRHELDLI
 ... | . |. .|..||. ..|.| |||.|| |. ...|| .  | .   |  | |||||.||.|| .|.  |  | .|  ||   |  . .| ..|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQILKPSE
 ||||||| || ||| |.|.|.|||  |  |. |   .. |.  |  ||  ||| .
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
Metallophos Calcineurin-like phosphoesterase 188-380 5.5e-45 147.1 Pfam-A 2-198 (200) alignment 
Range on Protein: 188-380
Range on HMM: 2-198/200.0
PLIICGDIHGQYTDL----LRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLL--LAYKIKYPENFFLLRGNHECASINRIYGFYDECK----------
. ...||.||.. ||    |.|.. .. ... ..|||||.||||. |.||..||  |..|...| ..||||||||. ..|  |||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIrrlmrptdvpdtgllcdllwsdpdkdvqgwg
                         ... . .  . ..|..|| .|..| ||...||.||....  ..|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

endrgVSFTFGVDVVSKFLNRHELDLICRAHQV
      |. || |...|.|... .||..|.|. 
.....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 188-318 6.3e-38 123.5 In-house 65-201 (383) alignment 
Range on Protein: 188-318
Range on HMM: 65-201/383.0
PLIICGDIHGQYTDLLRLFEYGGFPPAA-NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY---NVKLWKTFT
 . .|||.||.  ||| ..   |.| .  .|.| ||.|||||.|.| ...|||. . ||....| |||||   .|  |||  | . .|   . |. ... 
evtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlle

DCFNCLPVAAIIDEKIFCCHGGLSP--DLQGMEQIRR
| |  ||.|..|||||. .|||.|   ||. ...| |
dvfawlplatlidekilivhGGisdktdlelldkier
subfamily_YNL217W_pd Subfamily YNL217W 189-297 1.5e-08 27.5 In-house 12-127 (235) alignment 
Range on Protein: 189-297
Range on HMM: 12-127/235.0
LIICGDIHGQYTDLLRLFE--YGGFPPAANYLFLGDYVDRGKQSLETICLLlaykikYPENFFLLRGNHECASINRIygfydECKRRYNVKLWKTFTDCF
|.. ||.|| | .|..|..   ||  . .  ...|| ...| .|.|.. ..        ..   ..|||| . . ..     .  .. .    ..|.. |
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkpkgaeplefsskf

NCLP---------------VA-AIIDE
. |.                .  |  .
sflesklskadmeyarelgfsldipsd
PPP_2 190-380 1.2e-81 266.2 In-house 2-197 (198) alignment 
Range on Protein: 190-380
Range on HMM: 2-197/198.0
IICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECK-RRYNVKLWKTFTDCFNC
 .|||.|||..|||.||..|...|  .||||||||||||.|||...||||.|..||....|||||||....|..|||..|.. .... |..|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLL----WSDPDKDVQGWGENDRGVSFTFGVDVVSKFLNRHELDLICRAHQV
||.||.||||....|||||.... ..||..  |....|..|.|.|||    .|||... ... .. ||....|| ||....|....|.||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 190-380 2.4e-78 255.7 In-house 2-196 (197) alignment 
Range on Protein: 190-380
Range on HMM: 2-196/197.0
IICGDIHGQYTDL-LRLFEYGGFPP-AANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNVKLWKTFTDCFN
...||||||..|| |.|...||.|.   .|.||||||||||.|||...||||.|..||....|||||||..|.|..|||..|...... ...|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVP-DTGLLCDL-LWSDPDKDVQGWGENDRGVSFTFGVDVVSKFLNRHELDLICRAHQV
.||.||.||||....|||||..|. ...|.|. |....| . ....|| ||||| .. .|. .. ||....|| ||..|||....|.||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 190-381 2.3e-74 242.7 In-house 2-199 (199) alignment 
Range on Protein: 190-381
Range on HMM: 2-199/199.0
IICGDIHGQYTDL-LRLFEYGGFPP-AANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRR-YNVKLWKTFTDCF
..|||.|||. || |.||. ||.|.   .|.||||||||||.|||...||||.|..||....|||||||. ..|.||||..|.... .. |..|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVP-DTGLLCDL-LWSDPDKDVQG-WGENDRGVSFTFGVDVVSKFLNRHELDLICRAHQVV
..||.||.||||....||||||... .|..... |....| ..|  .|| ||||| ....| . .. ||....|| ||..|||....|.||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 215-429 2.3e-96 315.7 In-house 101-315 (317) alignment 
Range on Protein: 215-429
Range on HMM: 101-315/317.0
ANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGME
 .|||||||||||  |.| . ||.|.|..||.. ||||||||  ..|. |||| |.|.||...|...|   ||.||..|....||.| |||.| .|  ..
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMT
|. .| ||.|.|| |.|.|| |.|||..|.|. |  || .. || . | .||....|||. |||||||||||||| |.|||.||||.|||..||.. ...
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDDTLMCSFQILKPS
||. |..|...|.|.
vdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 216-432 1.8e-72 237.3 In-house 121-337 (339) alignment 
Range on Protein: 216-432
Range on HMM: 121-337/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQ
 |||||||||||  |.| . || | |. ||.  .|||||||  |.|  |||| | . ||. .|.. | . || .|..|.|.. |.| |||.|  |  ..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTV
.  . || ..|| |.| || |.|||   .|.    || || ||   .  ||.. .|... | |||||||||||  |.|||.||||||||. ||.  ....
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DDTLMCSFQILKPSEKK
|  |  | ....|  . 
dkklkisinvfrpesrd
subfamily_PPP7C_pd Subfamily PPP7C 331-424 7.3e-20 64.0 In-house 237-330 (383) alignment 
Range on Protein: 331-424
Range on HMM: 237-330/383.0
LCDLLWSDPDKDVQGWGENDRGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGMMTVDDTLMCSFQ
. |.||||| ..   . .  ||    || || .|.|....|.|. |.|.   .||||   ....|.||| ||  |  | |  . . ..|.  . 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpriv