Gene Pp1alpha-96A in Drosophila melanogaster

Synonym: CG40448, DmPp1-Y2, Dmel\CG40448, Pp1Y2, Dmel_CG40448, Pp1-Y2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP091_AA protein Get Run
DmelP091_AA_5-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 5-300 3.5e-127 416.7 In-house 1-297 (299) alignment 
Range on Protein: 5-300
Range on HMM: 1-297/299.0
MNIDSIISRLLEVRGARPGKNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
...| ..|.||.|  .       . | |...||  ....|.||. |||.|||...|||||||| ||||.|.  ||||..|.||||||||||.| ||.|.|
ldvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitl

LLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYT-IKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLL
||..|||| |.||.||||||| .|||.||||.||..||.  .||  | |.|. .|.. ..  .|.| |||||| |....|.| . || | |.  |  |||
llcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidll

WSDPDKDTMGWGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADKR
|.|||.  ..|  | ||||. || .|| . ... . ||..||||||.|||||||...|||.|||| |||.|||. |.| ||. |.|.|..|||..|.
wadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_PPZ_pd Subfamily PPZ 6-299 8.5e-141 461.7 In-house 2-296 (300) alignment 
Range on Protein: 6-299
Range on HMM: 2-296/300.0
NIDSIISRLLEVR-GARPGKNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
.|| || .||.    |.  ||| | .|||  .| |.||.||.|| ||||  ..|| ||.|||| ||||||   |||| .||||||||||||||||||| |
dideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletill

LLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLW
||.||||| ||||||||||||| . |.||||||||||  ||.|||| | || ||.||||  |||| |||||| | ||..||...||||||| ||. ||||
llcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllw

SDPDKDTMGWGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADK
|||   .  | .|.||||. .    . |||.|  |||.|||| |||||||||  | |||.|||||||||||| ||.||| . |.|||..| | | 
sdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 6-299 7.9e-136 444.9 In-house 2-296 (298) alignment 
Range on Protein: 6-299
Range on HMM: 2-296/298.0
NIDSIISRLLEVRGARPGKNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
..|......|.|  .      ...|... .|. ....|| .|. |.|..||.|.|||||||| ||||||. .||||..||||||||||||.|.||.|.||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRY-TIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLW
||||.|| .|||||||||||..|||.||||.||||||  ..|...| | || ||..|.. ..|.| |||||. |.|..|.|.. ||.| ... |  ||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

SDPDKDTMGWGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADK
.||.. . || || ||||..||..|| ..|.| . ||..|||||| |||||||...|||.||||.|||.|||. |.|.||. |..||..|||..|
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekk
0049330 Metallo-dependent phosphatases 6-300 9.4e-115 375.8 In-house 8-302 (309) alignment 
Range on Protein: 6-300
Range on HMM: 8-302/309.0
NIDSIISRLLEVRGARPGKNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
 ....| .||..   .. | ..|||.|.. |.|| .||..|.|.||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||...||
lllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevllll

LAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWS
||.|..| .|.||||||||.. .|..|||.||..|.| ..||. |.|....||.||....||.|.|||||||| ...|||...||...|. |||||||||
lalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllws

DPDKDTMGWGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADKR
||. .. |...|.||....||. .| .||.|. .|||.|.|..|..||..|....|.|.||||||||...|.||.. .|..|..||....|..  
dplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
0045823 Metallo-dependent phosphatases 7-300 5.1e-118 387.6 In-house 30-327 (473) alignment 
Range on Protein: 7-300
Range on HMM: 30-327/473.0
IDSIISRLlevrgarpGKNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLL
.| .|..|         |. .|.|.....|. . .||. ..| ||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||...|||
ldlliehl........kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelll

AYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSD
|.|||| .|.||||||||.. .| .|||.||. ..|...|.. | .....||.||....||...||||||||....|||.| || ..|| |||.||||||
alkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsd

PdKDTMG--------WGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQ------LVTLFSAPNYCGEFDNAGAMMSVDDTLmCSFQ
|  ...|        .| . ||....||...| .||.|. .|||.|.|..|..|||.. ...      ..|.||||||||...| .|.. .|..| .||.
P.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfi

ILKPADKR
...|..  
qfdpsphp
0053225 Metallo-dependent phosphatases 10-296 1.7e-105 345.5 In-house 4-290 (293) alignment 
Range on Protein: 10-296
Range on HMM: 4-290/293.0
IISRLLEVRGARPGKNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYK
.| .||..   .  ....|||.|.. |.|. .||....|.||||.... ..|||||...|||.|.|. |||||....||||.|||| .|||...||||.|
lilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalk

IKYAENFFLLRGNHECASINRIYGFYDECKRRY-TIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPD
..| .|..|||||||.. .| .|||.||..|.|   .||. ..|....||.||....||...|||||||||...|||.|.||...|. |||.||||||||
llypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd

kDTMGWGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKP
 . .||. . ||....||. .| .||.|. .|||.|.|||| |||... ...|||.||||||.|...|.||.. .|. |...|....|
.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_PPP1C_pd Subfamily PPP1C 21-299 1.1e-163 536.2 In-house 3-281 (282) alignment 
Range on Protein: 21-299
Range on HMM: 3-281/282.0
RPGKNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLR
..||.|.|.|.||..|. |.|||.||||||||||||.||.|||||||.|||||||..|.|||||||||||||||||||||||.|||||||||.||.||||
kkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllr

GNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRG
||||.|||||||||||||||||.|||||||||.|||||.||.|||||.|.||||||.|.|.||||.|.||..||..|||||||||||||...||.|||||
GnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrG

VSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADK
||||||..|| |||||...|||.||||||||||||||||||||.|||||||||||||||..|||..|..||||||||.|
vsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 25-298 6.2e-100 327.0 In-house 5-278 (281) alignment 
Range on Protein: 25-298
Range on HMM: 5-278/281.0
NVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHE
.||... || ..  . . || ..  | |...| .. ||.|.|. || ||||  | .||  ..|||||||||.||||.. ||...||.| .. .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFT
 ||.|.||||| ||. .| ..||  |  ||| ||..| ..... | ||||||.| .....| . .| . .|.||. ||||.|||.....| .  ||.|||
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPAD
|| .|| .  .. | .|| |||||| |||| .. |.|.|.||.||||  . ||.|.. ||.||  |.. | || 
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 25-292 7.1e-76 248.3 In-house 17-287 (307) alignment 
Range on Protein: 25-292
Range on HMM: 17-287/307.0
NVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHE
..| .  |.  .  ... || |.  |.... |  . ||.|||. ||. .|   | |||. |.| |||||||  |||.| ||..||| |.||  |||||||
kiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhe

CASINRIYGFYDECKR---RYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGV
 | .|. ||||.||     .   ..|  |  ||| ||..|..  ||.| |||||| |. ....|   .|   | .|.. |.||.|||   . |    || 
iarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgs

SFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQ
 ||||..|.    ..   .|| ||||.. |||  .. |.|.|.|||| ||  . |||... ||.||     
gftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlv
subfamily_PPP2C_pd Subfamily PPP2C 26-300 5.4e-103 337.2 In-house 15-289 (290) alignment 
Range on Protein: 26-300
Range on HMM: 15-289/290.0
VQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHEC
 ||.|||...|| | .||. ..  . |...|. .|||.|||..||| ||  ||  |..||||||||||||  |.||..|| | |..| |   .|||||| 
kqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhes

ASINRIYGFYDECKRRYT-IKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDTMGWGENDRGVSFT
  | ..||||||| |.|.  ..|| ||| |..||..|.|||.||| |||||| ......|| . |  .||..| |||||||||| |  |||  .||  .|
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagyt

FGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADKR
|| ..  || .. .. || ||||.| .||..  .|..||.|||||||    | .|.. .||.|  ||   .|| .|
fgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_PPP3C_pd Subfamily PPP3C 26-289 1.7e-88 290.4 In-house 39-315 (452) alignment 
Range on Protein: 26-289
Range on HMM: 39-315/452.0
VQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHEC
 .|.|...  .  .. ... ... |||.|||. ..||||||.||||.||| || | ...|||||||||||  |.|..  |.| ||.|....|||||||||
grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhec

ASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMG------WGEN-D
  .   . | .||| .|. .........|..||.||..... .|.||||||...|...|... |  ..| .|.||||||||| .|         . .|  
rhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsv

RGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAK------RQLVTLFSAPNYCGEFDNAGAMMSVDDTLMC
|| |. .. . | .|||| ..  | |||.. ..||. . |        |.||||||||.. ..| .|.. ...  | 
rGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvmn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 26-295 9.6e-69 224.8 In-house 5-299 (302) alignment 
Range on Protein: 26-295
Range on HMM: 5-299/302.0
VQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYA
 ..|.||. .|. .  | .  .  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. | 
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlyp

ENFFLLRGNHECASINRIYGFYDECKRRY----TIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRP-TDVPDQGLLCDLLWSDP-
.|. |||||||. .||  ||| .| . |.    . ..|. | ..|  .|.||.| |||.| |||.|| |.|.|.|..| || ..| .. |  |||..|| 
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl

DKD-------TMGWGEN-DRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILK
| .       .  . .|  ||.|..|    | .. .. ...|| ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|.
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_PPP6C_pd Subfamily PPP6C 27-295 3.6e-92 301.6 In-house 14-282 (290) alignment 
Range on Protein: 27-295
Range on HMM: 14-282/290.0
QLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECA
 |.|.... || .  ...| .  .  ...|. .|||||||.|||. ||  ||  |...|.||||.||||  ||||. .||. |.|| ..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRYT-IKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDTMGWGENDRGVSFTF
 | ..|||||||...|   . || .|. |. |..|||.||...| |||||||.  ..||| | | ...| .| .|||.||||. |   |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgagylf

GAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILK
|..|. .|..  ...|||||||.||.|.... . .|||..||||||    |  ......|.   .....|
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_PPG1_pd Subfamily PPG1 27-297 5.9e-85 278.1 In-house 13-296 (300) alignment 
Range on Protein: 27-297
Range on HMM: 13-296/300.0
QLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECA
 | |. ...|. | .|.....  . |...|. . ||.|||.||.| .|. ||  |..||||||||||||  |.||| ||.. |..|     |||||||  
llpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesr

SINRIYGFYDECKRRY--TIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPD---------KDTMG--
 | ..|||| || |.|    ..|| .|. |. | .|||.||.|.| ||||||.  |..||. . |  .||..| |.|||||||.          |  |  
qitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqh

WGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
. . .||  ...| .|| |||.. ... | ||||.. .||. .   .| |..||||||    |  ... . . .   |.. . |
fvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeea
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 27-297 3.8e-84 275.1 In-house 15-289 (290) alignment 
Range on Protein: 27-297
Range on HMM: 15-289/290.0
QLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECA
 .|...| ..  | .||.   | |||.|||. | ||||||  .||| |.  |.||. ..|||||||||| .|||   ||. |||.|...  |||||||. 
afsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevr

SINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTD--VPDQGLLCDLLWSDPDK---DTMGWgENDRGV
 .||.|||..|  |. . .||| . | |. |.. | |..||.| |||.|... | | .. . .|      |.||  ||||.||..   ||.   .  |..
kvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtial.nkqrai

SFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
|  || ... ..|.|  ..|| |||.| |.|..|  ...|||.|||| |.|.  | ||.. | ..|  |. .||| 
svvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 27-295 4.7e-69 225.9 In-house 5-298 (302) alignment 
Range on Protein: 27-295
Range on HMM: 5-298/302.0
QLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAE
..|.||. .|. .  | .  .  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. | .
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlypt

NFFLLRGNHECASINRIYGFYDECKRRY----TIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRP-TDVPDQGLLCDLLWSDP-D
|. |||||||. .||  ||| .| . |.    . ..|. | ..|  .|.||.| |||.| |||.|| |.|.|.|..| || ..| .. |  |||..|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

KD-------TMGWGEN-DRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILK
 .       .  . .|  ||.|..|    | .. .. ...|| ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|.
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
PPP_3 28-295 2.6e-113 370.5 In-house 2-270 (271) alignment 
Range on Protein: 28-295
Range on HMM: 2-270/271.0
LSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECAS
|||.|...|. | .||. ....|.|..||...|||||||..|||.||..||..||..||||||||||||.|||...||||.|||| ....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFG
||..|||..|.. .... |..|.....|..||.||..|||....||||||...|..||... |...||..|.|.|||.|...... |.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

AEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILK
..|. .||.|....||.|||...|.|||.......||.|||||||....||||.......|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 28-296 1.2e-111 365.7 In-house 8-282 (284) alignment 
Range on Protein: 28-296
Range on HMM: 8-282/284.0
LSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFP------PESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRG
|.| |.  ||...||.|  ... ||.|||.||.||||||. ||| |..  |.|       |..|||||||||||  |.| | ||.|||... .. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGV
|||   .|. |||| |||.||. .|...|  .||..|..|.|..||.| |||.| || ...|. .. ||.|.|| |...|| |.||... .|. | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKP
  .|||. | .||.|...||. |||||| ||||||| |.|||.|||| |||..||..|...||. |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 28-297 2.2e-104 341.9 In-house 23-295 (297) alignment 
Range on Protein: 28-297
Range on HMM: 23-295/297.0
LSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECAS
..|  .  |   . ..| .|  ..|..||.|.|||||||. ||||||  ||.|| .||||||||||||. |.||| ||||||.|.  |.|||||||||  
iteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

INRIYGFYDECKRRY-TIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSP---DLSSMEQIRRIMRPTDVpDQGLLCDLLWSDPDKDTMGWGENDRGVSF
.|..||||.||..|| ..... .| | || ||.. .. .||.| ||||||   .  ... .|.| |.|.   ..|..||||.||     |. ||.||   
vnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrgagc

TFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
 || . | |   . ..||.|||||||.||||||| |.|||.|||| |||.|||. |.||.|. | |||.||.|.
gfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_PPP4C_pd Subfamily PPP4C 28-297 2.4e-103 338.3 In-house 16-285 (288) alignment 
Range on Protein: 28-297
Range on HMM: 16-285/288.0
LSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECAS
..|.|...|| |.|||.. .  . ....|  .|||||||.||||.||. ||  || |||||||.||||. |.||. ||||.|..| ..  |.|||||. .
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

INRIYGFYDECKRRYT-IKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDTMGWGENDRGVSFTFG
| ..||||||| |.|  ...|.  |. |. |..|||.|.|||| ||||||..|....|| | | ..||..| |||||||||. |. ||.   ||  . ||
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylfg

AEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
..|| .| .. ...|||||||.| .|| .  .....|..||||||    |  |.. .|..|   |.|.. |
sdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 28-299 3.1e-95 311.4 In-house 10-284 (287) alignment 
Range on Protein: 28-299
Range on HMM: 10-284/287.0
LSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECAS
.|...| ..  | .||.   | |||.|||..|.||||||. ||||.|.  | .|. .||||||||||| .||| . ||...||.|...  |||||||.  
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

INRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVP--DQGLLCDLLWSDPDKDTMGWGEND-RGVSFT
||..|||..| ||..  .|.|.| | |. ||. |.|...|.| |||.||.| |..... . .||     |.||  ||||.||.||. .   |  |..|  
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

FGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADK
|| ..| ..|.| . ||| |||.|.|.||.|.....|||.|||| |.||  | ||.. |...|  ||  ||| | 
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 28-81 1.7e-17 56.6 In-house 9-62 (317) alignment 
Range on Protein: 28-81
Range on HMM: 9-62/317.0
LSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPP
..|.|.  ||...||.| ..|. ||||||..|.||||||. ||| |..  |.| 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 29-297 7.6e-120 392.2 In-house 7-275 (280) alignment 
Range on Protein: 29-297
Range on HMM: 7-275/280.0
SESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASI
 | .| ..  | ..|.. |  ..|..||...|||.|||| ||||||.  .|||..||||||||||||.| || |.||||||..| .||..||||||..||
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

NRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAE
|| |||.||.||||. .|.. | . .. ||..|.|  .|.| |||||..| |........|| | .|. |  ||||.||.... ||.|| ||||  |||.
nrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifgan

VVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
|| .. .| . |||.| ||||.|||||||...|||.||||.|.|||||. |.. ||. |. ||..||||
vvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
PP2Ac_SM00156 29-297 1.9e-115 377.6 In-house 2-270 (271) alignment 
Range on Protein: 29-297
Range on HMM: 2-270/271.0
SESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASI
|..|...|. ...||. ... |.|..||. ..||||||..|||||.| .|.|||..|.|||||||||.||.|.|.||.|.||.| |...|||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAE
|.||||..|.||.|. .... |...|..||.||.||.||.| ||||||.|.|...||.. |. . |..|||.|||||||.....|.  . ||.|..||..
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

VVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
.| .||.|....||.|||.||..||||||...|||.|||||||.||.|..|...|...|..|.. ||..
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
PPP_1 29-283 8.8e-114 372.2 In-house 2-264 (264) alignment 
Range on Protein: 29-283
Range on HMM: 2-264/264.0
SESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASI
.|.|...|. |..|.. ....|||.......|||||||..|||.||..||..||.|||||||||||||.|.|...||||.|.|| ...||||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECK-RRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLL-------WSDPDKDTMGWGENDRG
...|||..|.. ..|. ...||.||.|..||.||..||||...||||||.|....|||...| |.||..| |||||       .||........ ...||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV
....||..|. |||||....||.|||.|.|.||||..||..||.|||.||. |..|.||....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 30-82 1.4e-12 40.4 In-house 13-65 (339) alignment 
Range on Protein: 30-82
Range on HMM: 13-65/339.0
ESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPE
 .|.  || ..||.  |.||.|.||||. . ||||||. ||| ...  |.|  
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 31-299 4.5e-106 347.4 In-house 6-276 (284) alignment 
Range on Protein: 31-299
Range on HMM: 6-276/284.0
SEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINR
 .. .| ... .||  ||.|.| ..|..||||||||. ||||||.  |||  .|||||||||||||. |||| ||.|||. . . ||.|||||||. ||.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

IYGFYDECKRRYTI-KLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQG-LLCDLLWSDPDKDTMGWGENDRGVSFTFGAE
|||||.||.|||    ....|   |  .|..|.| ..|.| |||.|  |  . |.| | || | |.   |  |.||||| .   ||  | ||||. ||..
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

VVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADK
 . |.|.. . ||. ||||||.|||||||.|.|||.|||| |||.|||| |.| |.  |.||| .|.|  |
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 31-297 2.8e-89 292.3 In-house 9-275 (280) alignment 
Range on Protein: 31-297
Range on HMM: 9-275/280.0
SEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINR
 || ..      ||. .  | | |||.|. |||| || |. |||.  |  || . .||||||||| | .| . ||.. ||.| .  .|||||||  |.|.
heiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnk

IYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAEVV
||||| ||. .| . ||  |  ||| .|..... ....| ||||||.|  .. || | || .  |.||| ||||||| .   ||  . ||.|. ||  ||
iygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvv

GKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
 .  .  | ||| ||||||.||||..| |.|.|.|| |||| .| || |.. ..  |  ||| | | 
eqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_PPPLV_pd Subfamily PPPLV 34-287 4.2e-57 186.7 In-house 3-279 (290) alignment 
Range on Protein: 34-287
Range on HMM: 3-279/290.0
RSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLL----RLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASIN
 ||| .. .|....  ||||..|  . ||.||.| ||      |.  |     ...||||||||||. |.| |. ||| |. |   ..|||||||  |. 
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

RIYGFYDECKRRYTIKL---WKTFTDCFNCLPVAAIVDEKIFCCHGGLSPD------LSSMEQIRRIMRpTDVPDQGLLCDLLWSDPDKD----------
  . .. |.. ..  .|   |..|...|. ||.||..|.|.||.|.|.         .|....|   ..  |.    |  |.|||||..|          
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlk.ddidgaplaldilwsdpaedrdlslrgelv

-TMGWGEND-RGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAgAMMSVDDTL
   |. .|| || .  |... . .||.. . . . |||.| | |...  | .|.|.||. .|||  ..| |.. ||   
lneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssnea.alilvdkkk
subfamily_PPP5C_pd Subfamily PPP5C 36-287 5.3e-83 271.7 In-house 42-299 (322) alignment 
Range on Protein: 36-287
Range on HMM: 42-299/322.0
LCLKSREIFLSQPILLELEAP----LKICGDIHGQYYDLLRLFEYGGFPPES-NYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINR
. |...|.. ..| |.|.. .    | .|||||||.|||| .||  | | |.  ||| ||.||||  |.|.| .||..|. | ..||| |||||  ..|.
illeakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnk

IYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGL-SPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKdTMGWGENDRGVSFTFGAEV
.||| .|.| .|| |. . ||. || ||.| ...||.. .|||| | |  .....|.| | .. |..|||..||||||.. ..| ..  |||...|| .|
lyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskrGvgvqfGpdv

VGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV-DDTL
  |||.. ...|| |.|.| |.|||.  . .|.|.||||||| . .| ||.... .| |
tkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 50-298 1.3e-72 237.7 In-house 2-257 (263) alignment 
Range on Protein: 50-298
Range on HMM: 2-257/263.0
LLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYTI-----
||||.||..|||| |||| ||||.|.  |   ...||||||||||| .||| | ||.. |.    ...|||||||  .||. |||. | |.|.       
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPD-QGLLCDLLWSDPDKDTMGWGEND-RGVSFTFGAEVVGKFLQKHEFDLI
 ... | . |. .|..||| ..|.| |||.|| | |...|| |  | .    . | |||||.||.||. |.  |  | .|  || . |  . .. . |||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPAD
 ||||||| || ||| |.|.|.|||  |  |. |  |.. |.  |  ||  ||| |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
Metallophos Calcineurin-like phosphoesterase 57-248 4.7e-44 144.0 Pfam-A 3-198 (200) alignment 
Range on Protein: 57-248
Range on HMM: 3-198/200.0
LKICGDIHGQYYDL----LRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL--LAYKIKYAENFFLLRGNHECASINRIYGFYDECK-----------
  ..||.||...||    |.|.. .. ..  ..|||||.||||. |.||..||  |..|...  ..||||||||. ..|  |||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIrrimrptdvpdqgllcdllwsdpdkdtmgwge
                        ... . .  . ..|..|| .|.|| ||...||.||... | ..|                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ndrgVSFTFGAEVVGKFLQKHEFDLICRAHQV
     |. || ... |.|.|.  ||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 57-189 2.4e-37 121.5 In-house 66-201 (383) alignment 
Range on Protein: 57-189
Range on HMM: 66-201/383.0
LKICGDIHGQYYDLLRLFEYGGFPPE-SNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRY---TIKLWKTFTD
. .|||.||.  ||| ..   |.| |  .|.| ||.|||||.|.| ...|||. . | ....| |||||   .|  |||  | . .|   . |. ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPVAAIVDEKIFCCHGGLSpDLSSMEQIRRIMR
 |  ||.|...||||. .|||.| | ...| . .| |
vfawlplatlidekilivhGGis.dktdlelldkier
PPP_2 58-248 1.8e-81 265.6 In-house 2-197 (198) alignment 
Range on Protein: 58-248
Range on HMM: 2-197/198.0
KICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINRIYGFYDECK-RRYTIKLWKTFTDCFNC
..|||.|||..|||.||..|...||..||||||||||||.|||...||||.|..| ....|||||||....|..|||..|.. .... |..|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLL----WSDPDKDTMGWGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQV
||.||..|||....|||||.......||... |....|..|.|.|||    .|||.... .. .. ||....||..|. ..|.|....||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 58-248 1.2e-78 256.7 In-house 2-196 (197) alignment 
Range on Protein: 58-248
Range on HMM: 2-196/197.0
KICGDIHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFN
 ..||||||..|| |.|...||.|. |..|.||||||||||.|||...||||.|..| ....|||||||..|.|..|||..|...... ...|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKDTMGWGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQV
.||.||..|||....|||||..|.|...|.|| |....| ......|| ||||| ... |. .. ||....||..|. |||.|....||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 58-249 4.6e-75 245.0 In-house 2-199 (199) alignment 
Range on Protein: 58-249
Range on HMM: 2-199/199.0
KICGDIHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRR-YTIKLWKTFTDCF
 .|||.|||..|| |.||. ||.|. | .|.||||||||||.|||...||||.|..|.....|||||||. ..|.||||..|.... .  |..|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKDTMG-WGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVV
..||.||..|||....||||||.. |.|....| |....| ..|  .|| ||||| ... | . .. ||....|| .|. |||.|....||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_YNL217W_pd Subfamily YNL217W 58-177 1.7e-08 27.3 In-house 13-139 (235) alignment 
Range on Protein: 58-177
Range on HMM: 13-139/235.0
KICGDIHGQYYDLLRLFE--YGGFPPESNYLFLGDYVDRGKQSLETICLLlaykikYAENFFLLRGNHECASIN------RIYGFYDE--CKRRYTI--K
 . ||.|| | .|..|..   ||  ..   ...|| ...| .|.|.. ..        ..   ..|||| . .       .  |. .    ..  ..  |
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsflesk

LWKTFTDCFNCLPVA-AIVDEKIFCCHGGLSPD
| |  ..    |. .  |  ....  |.||.| 
lskadmeyarelgfsldipsdellvvhaGlvpg
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 83-297 7.1e-96 314.1 In-house 101-315 (317) alignment 
Range on Protein: 83-297
Range on HMM: 101-315/317.0
SNYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSME
..|||||||||||  |.| . ||.|.|..| .. ||||||||  ..|. |||| |.|.||  .|...|   ||.||..|.|..||.| |||.| .| ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMS
|. .. ||.|.|| |.|.|| |.|||..  |. |  || .. |||. | .||.|...||. |||||||||||||| |.|||.||||.|||..||..|..|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDDTLMCSFQILKPA
||. |..|...|.| 
vdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 84-298 6.1e-73 238.9 In-house 121-335 (339) alignment 
Range on Protein: 84-298
Range on HMM: 121-335/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLSSMEQ
 |||||||||||  |.| . || | |. | .  .|||||||  |.|  |||| | . ||  .|.. | . || .|..|.... |.| |||.|  |.|..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV
.  . || ..|| |.| || |.|||    |.    || || ||   .  ||.| ..... | |||||||||||  |.|||.||||||||. ||. |..|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DDTLMCSFQILKPAD
|  |  | ....|  
dkklkisinvfrpes
subfamily_PPP7C_pd Subfamily PPP7C 199-291 1.3e-20 66.5 In-house 237-329 (383) alignment 
Range on Protein: 199-291
Range on HMM: 237-329/383.0
LCDLLWSDPDKDTMGWGENDRGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSF
. |.||||| ...  . .  ||    ||..|  |.|||....|. |.|.   .||||  .....|.||| ||  |  | || . . ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri