Gene CanA-14F in Drosophila melanogaster

Synonym: 5559, CG7109, DmPp2A-28D, Dmel\CG7109, ER2-6, MTS/PP2A, Mts, PP2, PP2A, PP2A 28D, PP2A C, PP2A-C, PP2A[C], PP2A[[C]], PP2Ac, PP2a, PP2a 28D, Pp2A, Pp2A-28D, dPP2A, dPP2A-C, l(2)02496, l(2)s5286, Dmel_CG7109, mts

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP097_AA protein Get Run
DmelP097_AA_156-359 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 88-550 3.3e-152 500.2 In-house 2-471 (473) alignment 
Range on Protein: 88-550
Range on HMM: 2-471/473.0
ERVIDSVAFPPSRKLTCADVFDARtGKPQHDVLKQHFILEGRIEESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKY
.||...| .|..|.|| . .|.   |....|.|..|.. ||...|. .|....| . .|. |...........|.||||||..||..|.|. | |  ...
drvlklvlipvlrlltlpllfill.glldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrl

LFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIR
.||||.||||..|.|....|..||| ||.  ||||||||.|.|. .. |..|.  ||.|..|..... ...|||||. ....|.|||||||... |..||
vflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqir

RLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLD
...|. |.| .|...||||||| ||.|...    . .||.||..|.... | ..||..|.|  |.|.|.... ||..... ...|....||.||||||..
eierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcg

VYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSddEAALRKEVIRNKIRAIGKMARVFS
...|.||||..........||..||||..||.|.|||..||||..||.||.|...|||.|||||...|.. .|       ..|..||||.|.||..||||
rggnlaAvlvidedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddellededilgll..lleallellrnkilalgkllrvfs

VLREESESVLQLKGLTPTGALPLGALSGGKQSLKNAMQ----------GFSPNHKITSFAEAKGLDAVNERMP
||||||||||.||||||.| ||||.|. ||. | ....           ..|.....|. |.| |. .|||..
vlreesesvlllkgltpsgllplgllllgkelllesleealkldlineklppsllllsleeekslelinerle
subfamily_PPP3C_pd Subfamily PPP3C 89-551 7.1e-262 861.9 In-house 1-452 (452) alignment 
Range on Protein: 89-551
Range on HMM: 1-452/452.0
RVIDSVAFPPSRKLTCADVFDArTGKPQHDVLKQHFILEGRIEESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYL
||...|..|.|.||| ..|||  ||||...|||.||. |||.||.|||.||.|.|.||..|||....|||.||.||||||||||.||||.||.||.||||
rvvkkvplpkskklteeevfde.tgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkyl

FLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRR
|||||||||||||||||||..|||.||.|||||||||||||||||||||.||||||||.||||||..||.||||||.|||||||||||||||..|.||..
flGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikk

LDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDV
|||||||||.||.|||||||||||.|.||.......||||||||||||.|.|.|||.|.|||||||||||||||||||||..||||||||.|||||||||
ldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldv

YNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEAALRKEVIRNKIRAIGKMARVFSV
|||||||||||||||||||||.|||||||||||||||||||||||||||||||.|||||||||..||.||  ...|.. ||||||||||||||.||||||
ynnkaavlkyennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnicsddelekeeeeeskeesesekrkevirnkiraigklarvfsv

LREESESVLQLKGLTpTGALPLGALSGGKQSLknamqgfspNHKITSFAEAKGLDAVNERMPP
|||||||||.||||| ||||| ||||.||..|         ..|..||.|||.||..||..||
lreesesvlllkglt.tgalprgalsegkegl.........eeklssfeeakkldlineklpp
0049330 Metallo-dependent phosphatases 114-417 1.2e-95 313.2 In-house 14-305 (309) alignment 
Range on Protein: 114-417
Range on HMM: 14-305/309.0
KPQHDVLKQHFILEGRIEESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKIT
..  |.|..... .....|. .|.....  ..|..|...........|.||||||..||..|.|. | |  ....||||.||||..|.|..|.|..||. 
lslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkll

YPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDF
||.  ||||||||.|.|. .. |..|.. ||.........| ...|||||. ....|||||||||... |..||.|.|. |.|..|..|||||||||...
ypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

GNeknsdfyTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFNCSP
 .        ....||..... . | ..||. |.|  |||.|.|.. ||... . .      |||.||||||.....|..|||..... |.....|...|
eg.......fapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvfsapnycgrlgnlgavleidedlvisfllfepvp

HPYWL
....|
lllll
0053225 Metallo-dependent phosphatases 115-409 1.3e-89 293.4 In-house 7-289 (293) alignment 
Range on Protein: 115-409
Range on HMM: 7-289/293.0
PQHDVLKQHFILEGRIEESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITY
. .|.|.....|  .. |. .|....|  ..|..|...........|.|||||...||..|.|. | | .....||||.||||..|.|....|..||. |
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PQTLFLLRGNHECRHLTEYFTFKQECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDF
|.  .|||||||...|. .. |..|.. || .....|...| ...|||||| ....|.|||||||... |..||...|. ..| .|...||||||| . .
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

GNEKNSdfythnsvRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKsqttgfPSLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFN
|  ..         ||..... . |...||..|.|  |||.|.... ||... .      ..|.|.|||||||....|..|||..... |... .|.
gwlpsy........rglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
subfamily_PPP5C_pd Subfamily PPP5C 122-416 1.5e-80 263.6 In-house 26-314 (322) alignment 
Range on Protein: 122-416
Range on HMM: 26-314/322.0
QHFILEGRIEESAALRIIQEGATLLRTEKTMIDIEAP----VTVCGDIHGQFYDLMKLFEIGGSPATT-KYLFLGDYVDRGYFSIECVLYLWSLKITYPQ
..|  . ....  ||.|..|  .||... ....|. .    .|||||||||||||. .||. |.|...  ||| ||.|||| ||.|..| |...|. ||.
elfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPn

TLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLS-PEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGN
 .|| |||||  .. . . |..|.| ||.|.|.|   . |. |||| ..|...| |||||   .   |.|.|..||...||  | ...|||||| |  | 
hfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGr

eknsdfytHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY--ENNVMNIRQFNCSPH
         .| || .  .       ||..|||  |||.|| .. ||.. .. .      |||.|||||| |  .||.|...   ... .....|.  .|
........spskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGk......litvfsapnycdqmgnkgafitlrgddlklkfktfeaveh

PYW
|  
pdv
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 128-403 4.1e-76 248.9 In-house 22-285 (298) alignment 
Range on Protein: 128-403
Range on HMM: 22-285/298.0
GRIEESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHEC
  |.|.   ..|..   .... |......||..||||||||. ||..||. .| | .. ||||||||||| ...| .. | . |. ||. .|||||||||
kvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhec

RHLTEYFTFKQECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgNEKNSDFyThNS
 .. . . |..||| .| | |.| .  |.|. |||.||. .. ||.|||||.....|...|.| | ....      ||||.||     ... ... . ..
eainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadp.....enavkgw.a.en

VRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 || |. .   .  |.|.. ..  ..|||     || .. . .      |.||||||.|.. ..| |||.| .....
srGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekk......lvtifsaphycgqfdnsaavmkvdeklv
subfamily_PPP7C_pd Subfamily PPP7C 128-293 1e-33 109.6 In-house 31-203 (383) alignment 
Range on Protein: 128-293
Range on HMM: 31-203/383.0
GRIEESAALRIIQEGATLLRTEKTMIDIE----APVTVCGDIHGQFYDLMKLFEIGGSPATT-KYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLR
 ..     | |..| .  |.. . .  ..      ||||||.||.. ||. ..   | |..   |.| ||.||||  |.| .| | .| . ||. ..| |
kllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnr

GNHECRHLTEYFTFKQECKIKY---SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSpEIHELEDIRRLDRFK
||||   |   . | .| . ||   ....     | |  ||||.|.... | ||||.| .. .|| . ...| |
GnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 129-400 4.4e-62 203.0 In-house 22-283 (297) alignment 
Range on Protein: 129-400
Range on HMM: 22-283/297.0
RIEESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECR
 | |   |....    .....|.|....||. ||||||||| ||..||  || | |..||||||||||| |||| .. | . |. .|  |||||||||| 
viteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhece

HLTEYFTFKQECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP---EIHELEDIRRLDRFKEPpAFGPMCDLLWSDPLEDFgneknSDFYTH
 . . . | .||. .| | |.| |  | |. |||. |. .. ||.||||||   .   |. .|...| .|    . ..||||.||.  .     | |   
fvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisgl.....sgfmen

NSVRGCSYfySYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
.   || .     |  .   . .|  . |||.  . || ..   .      |.|||||| |   ..| ||..  ..
qrgagcgf..grdavlklcsefkldlvcrahqvvqdgyeffagrk......lvtifsaphycgqfdncaafmscde
PPP_3 130-403 5.6e-96 313.7 In-house 2-263 (271) alignment 
Range on Protein: 130-403
Range on HMM: 2-263/271.0
IEESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRH
..|. . ..... . .| .|.....|.||||||||||||..||..||..||....|||||||||||||..|.|..|.|..|||.||....|||||||.|.
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

LTEYFTFKQECK-IKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLedfgnekNSDFYTHNSVR
......||.|..  |....||..... |..||||||.....|.|||||||.|..|..|..|.|..| |  |...|||.|..        ...  ..||.|
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdp.......ekeeglenskr

GCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKsqttgfPSLITIFSAPNYLDVYNNKAAVLKYENNVM
|......  . ..||..|.|  ||||||....||.....       ...|.||||||.. ..|..|.|| |.. .
GagllFgpdvteefleknkLkliiRaHelkeeGyeilhd......gkvvtvfSapnycerasnagailkleealt
subfamily_PPP1C_pd Subfamily PPP1C 130-403 2.2e-87 285.8 In-house 10-270 (282) alignment 
Range on Protein: 130-403
Range on HMM: 10-270/282.0
IEESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRH
..|.   .....  ..| .. .....||||...||||||..||..|||..|.|....||||||||||| .|.| .. | ..|| ||..|||||||||. .
lkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesas

LTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgNEKNSDfYTHNSvRG
..... |. ||| .|| ... . .|.|.|||||||.... ||||||||||...||.||.. |  | |  | .||||||||     .... . ...|. ||
inriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdp.....dkevlg.wsend.rG

CSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 |. ..  .  .|||.|.|  |.|||.  ..||... | |      |.|.||||||.. ..|..|||. .....
vsftfgkdvvekflqkndldlivrahqvvedGyeffakrq......lvtvfsapnycgefdnagavlsvdeell
subfamily_PPP4C_pd Subfamily PPP4C 130-403 4.8e-82 268.4 In-house 16-276 (288) alignment 
Range on Protein: 130-403
Range on HMM: 16-276/288.0
IEESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRH
|.|.   .. ..   .|  |  .  ...|||||||||||||||..||..||.   |.||||||.||||..|.|. | | .||. ||. . |.|||||.|.
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

LTEYFTFKQECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGneknsdfYtHNSVR
.|. . | .||  || | .|.  |.. || |.|||..... .||||||||.|..|..|| .|| .| |  ||.|||||||| .  |       .   | |
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg.......w.avspr

GCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
|  |..   .. .| ..|..  |.|||.    ||... . .      ..|..|||||     |.||.|...... 
gagylfgsdvveqfneandielicrahqlvmegyklhfnek......vltvwsapnycyrcgnvaaileldeeld
subfamily_PPP2C_pd Subfamily PPP2C 130-412 1.8e-80 263.2 In-house 17-287 (290) alignment 
Range on Protein: 130-412
Range on HMM: 17-287/290.0
IEESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRH
.|||   .....   .|..|. . ....|||||||.||||.||..|| |||.   |.||||||||||||.|.|.| .| .||. |.. . .|||||| | 
leesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrq

LTEYFTFKQECKIKYSE-RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGneknsdfYtHNSVR
.|. . | .||  ||..  |.    | ||.|||.||...| .|.||||||.|. |..|| |||..| |  ||.|||||||| .  |       .   | |
itqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrgg.......w.gispr

GCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP
|. | .    . .| ..|.|  |.|||.    ||..  . .      ..||||||||     |.||.|. .... ... ||. .|
gagytfgkdisekfnktngltliarahqlvmegynwshdrn......vvtifsapnycyrcgnqaailelddklkysflqfdpap
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 130-401 6.2e-68 221.9 In-house 6-264 (280) alignment 
Range on Protein: 130-401
Range on HMM: 6-264/280.0
IEESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRH
|.|    |.|..   .| ...||....|||.||||.|||. ||..||.  . |  ..||||||||||| . .| .| | . |. ||.....||||||. .
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

LTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgnEKNSDFYTHNSvRG
. . . ||.|.| .||. .|.   . .| |||.||.. . ||.|||||...  |.|...| |  ...      ||||.||      |..   ...|| ||
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadp......enkvtgwaens.rg

CSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENN
.|. .      |. .  ..  |.| |.  . || .. . .      |.|.||||.||. ..|.||||. ...
vsvifganvvkdltekldidliarghqvvqdgyeffadkk......lvtvfsapkylgefdnsaavlivder
PPP_1 131-396 3.4e-105 344.1 In-house 2-262 (264) alignment 
Range on Protein: 131-396
Range on HMM: 2-262/264.0
EESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHL
||. . ..... ..||..|..........||||||||||.||.|||..||....|.|||||||||||..|.|..|.|..||. ||..|||||||||.|..
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TEYFTFKQECK-IKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRG
|....||.|..  |||...|....|.||.||||||.....|.||||||||.. |..||...|..| |. |..||||..|  ... ..|...  ..||.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

CSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTtgfpslITIFSAPNYLDVYNNKAAVL
..|.... . ..|||.||| .||||||....||....|...      .|||||.|| .. .|..|..
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkv......vtifsasnyyeegsnrgayv
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 131-400 2.6e-67 219.8 In-house 11-270 (287) alignment 
Range on Protein: 131-400
Range on HMM: 11-270/287.0
EESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHL
...  | ....   .|.  ......|||.|..||||||. ||...|.  | .. ..|||||||||||  |.| .|.|.||||.||. . |||||||....
sdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkki

TEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAF--GPMCDLLWSDPledfgnEKNSDFYTHNSVR
 . . ||.| | |..||.|    | |. ||| | .... ||.|||.||... |.... | . . | |   | . ||||.||      ||... .  | .|
nklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadp......ekdaktfelnkir

GCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
. |  .      |.|.. ..  |.|||| .. || .. . .      |.|.|||| |     | .||.. ..
aisvvfGkkevddllkkldidlivrahevseeGyaflfdkr......lvtvfsapyysgedtnlgavvvvsk
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 131-398 8.2e-57 185.4 In-house 17-275 (290) alignment 
Range on Protein: 131-398
Range on HMM: 17-275/290.0
EESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHL
...  | |...   .|.   .....|||... ||||||. .|.. |.  | |   |.||||||||||  |.|  |.|. .|| |.... |||||||.|..
sdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkv

TEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPP--AFGPMCDLLWSDPLEDfgnekNSDFYTHNSVR
   . ||.|   | . |..    | |. |.| | .... ||.|||.|..|.  | .. | . . |     | . ||||.|| .|      .| .. |  |
nrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrd.....kddtialnkqr

GCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY
. |  .   .  |.|..  |  |.|||| .. |. .  . .      |.|.|||| |     |  |... 
aisvvfgkkglddllkklalslivrahevkeegfnflfdkk......lvtvfsapyysgndtnlgaiatv
PP2Ac_SM00156 132-403 1.2e-104 342.1 In-house 3-261 (271) alignment 
Range on Protein: 132-403
Range on HMM: 3-261/271.0
ESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLT
.. .|....| ...|. ||......|||||.||||||..||..|.| .| |...||.|||||||||..|||..|.|..||| ||....|||||||.....
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

EYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgnEKNSDFYTHNSvRGCS
....|..|.|.||....|. ...||..||||||.....||.|||||||...|.|||.|.|.||.|  |...|||||||      |.. . ..... ||.|
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp......eqkekgfqpsk.rgls

YFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYENNVM
.... .| ..||..|||  ||||||..| ||... ..      .|.||||||||.| ..|||||||.|.|..
vvFgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlk
subfamily_PPP6C_pd Subfamily PPP6C 133-408 1.9e-73 240.1 In-house 18-281 (290) alignment 
Range on Protein: 133-408
Range on HMM: 18-281/290.0
SAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTE
. . .. .  . ||  | ..  ...|||||||||||||||..||  ||.   |.|.||||.|||||.|.| . .| .||. ||. . |||||||.|..|.
ndlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitq

YFTFKQECKIKYSE-RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPlEDFGNeknsdfYtHNSVRGCS
 . | .||. || .  ..  |.. || |..||....| |||||||||... |..|| ..| .| |  |..|||.|||| ||  .      . . | ||  
vygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvet......w.avsprgag

YFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQF
|..    . .|...|||  |.|||.  . |.. . . .      |.|..|||||     | |..|. |..   . . |
ylfgskvtkefvhinnlklicrahqlveeglkymfdek......lvtvwsapnycyrcgnvasilaledaeereaklf
subfamily_PPZ_pd Subfamily PPZ 133-400 5e-63 206.4 In-house 28-282 (300) alignment 
Range on Protein: 133-400
Range on HMM: 28-282/300.0
SAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTE
|  |.| ..   |. .. .....  .| . ||.|||. ||..||   | | ...|||||||||||  |.| .| |.  || ||. .|||||||||  .| 
seilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtr

YFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLeDFGNEKNsdfythNSVRGCSY
 . | .||| .   ... . .|.|. |||||..  . .|||||||| .  ...||.. |  . | || . |||||||  |  || .      .  || ||
vygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdpt.dssnewe......dnergvsy

FYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYEN
 |   |   ||..  .  . |||   . || ..         ||.|.||||||   ..|  ||.   .
cynkvainkflnkfgfdlvcrahmvvedgyeffndr......slvtvfsapnycgefdnwgavmsvse
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 133-402 5.1e-60 196.2 In-house 9-290 (302) alignment 
Range on Protein: 133-402
Range on HMM: 9-290/302.0
SAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIG-----------GSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLL
|  | .|..   ||..|||...| .|||. ||||||| ||....               | .. |..|||||||||. ||||.  ...||. ||.   ||
sellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHECRHLTEYFTFKQECKIKYSE----RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAF-GPMCDLLWSDPLEDFG--
|||||.. .   ..|..| ......    ....   ..|  .|||||. .. ||||||.|| .. ||||....|  .  .      |||..|||.  .  
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqlla

NEKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
  ..   |..| ||| |. .  ||  |. .. ||  |.|||    .|.... . .      |.||||||.|..  .|| |||| . | 
avsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 133-402 8.8e-60 195.4 In-house 10-291 (302) alignment 
Range on Protein: 133-402
Range on HMM: 10-291/302.0
SAALRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIG-----------GSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLL
|  | .|..   ||..|||...| .|||. ||||||| ||....               | .. |..|||||||||. ||||.  ...||. ||.   ||
sellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHECRHLTEYFTFKQECKIKYSE----RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAF-GPMCDLLWSDPLEDFG--
|||||.. .   ..|..| ......    ....   ..|  .|||||. .. ||||||.|| .. ||||....|  .  .      |||..|||.  .  
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqlla

NEKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
  ..   |..| ||| |. .  ||  |. .. ||  |.|||    .|.... . .      |.||||||.|..  .|| |||| . | 
avsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 136-402 5.1e-66 215.8 In-house 14-267 (281) alignment 
Range on Protein: 136-402
Range on HMM: 14-267/281.0
LRIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFT
  .|.|  ...  ||....|..|..| ||.|.|| || .|||. | .. ....|||||||||  |.|... |..|||.|.. ..|||||||  ..   . 
envireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiyg

FKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgneKNSDFYTHNSVRGCSYFYS
| .||. || | ..      |. ||..||.... ||.|||||||.  |...|   .  ...  | . ||||.||       .|. .  ..|.|| |. . 
fyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadp.......dnkveewkassrGssftfG

YAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
 .   |  .. ..  |||||    .||..    .      |||.||.||| . |.| ||||| ....
knvvddvckrleveliirahqvvqdGyevlsgrk......litvfsvpnycafyknaaavlkvdetl
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 137-401 5.4e-52 169.9 In-house 27-281 (307) alignment 
Range on Protein: 137-401
Range on HMM: 27-281/307.0
RIIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTF
 .| |  |.. .||...||. |. | ||.|||| ||...| . | |  | |.| ||||||| .|.||.| |.. ||.||. . |||||||  .. . ..|
nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygf

KQECKI---KYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgneKNSDFYTHNSVRGCSYF
 .||     |  | ..     .|. ||..||.  . ||.|||||| .  |...|   .    |  | . |.||.||         | |  . | ||  . 
yeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadp.......dpsvfewkassrgsgft

YSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYENN
.      |  .   .  |||||.    || .           |||||||| | ..|.|  .||| .. 
fgtnviddvckrlgveliirahqmcfdgywvlsgr......klitifsapmycnfyknagcvlkvdet
subfamily_PPG1_pd Subfamily PPG1 138-401 1.2e-72 237.7 In-house 22-285 (300) alignment 
Range on Protein: 138-401
Range on HMM: 22-285/300.0
IIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFK
...    || .|  .|.|..|||| ||.||||||....|.|||    |.|||||||||||..|.| .  |  ||. ||  . ||||||| | .|. . | 
ltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfy

QECKIKY--SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDF----GNEKNSDFYTHNSVRGCS
 ||  ||    ||..   . || | |||.....  ||||||||..  ...|. ||||.| |  | ..||||||| |.      .  ..  .  .| ||. 
teclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrgag

YFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTgfpsliTIFSAPNYLDVYNNKAAVLKYENN
| |       ||.||..  |||||.    ||...  .. .      |..|||||     |||..|. ...
ysygkdvvekflrnndmnriirahqlcnegyqilfdnkls......tvwsapnycyrcgnkasilelyek
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 138-407 8.3e-55 179.2 In-house 14-271 (280) alignment 
Range on Protein: 138-407
Range on HMM: 14-271/280.0
IIQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFK
||.   ...  |  ... |||. | |||| |. |. .||.. |     | .|||||||||   || .. |. ||| | . ..|||||||   . . . | 
iirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfy

QECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLedfgNeKNSDFYtHnSVRGCSYFYSYA
 ||. ||   ..     .|. .|...|.... ||.|||||||. .|. || . |  ||   | . |||||||     | |   .. | |.|| ||..  .
vecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdpt....n.kgegwf.h.sirgisymfgkg

ACCDFLQNNNLLSIIRAHEAQDAGYRMYrksqtTGfPSLITIFSAPNYLDVYNNKAAVLKYENNVM-NIRQ
   .  .. ..  |||||.  . || |      .|   |||.|| |||   . | |||.  . |.  ...|
vveqacksleidliirahqvvqdgyemm.....ag.rrlitvfsvpnycaqftnaaavvclnanlqvsfqq
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 139-403 3.8e-63 206.5 In-house 33-285 (299) alignment 
Range on Protein: 139-403
Range on HMM: 33-285/299.0
IQEGATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQ
 .   . .  . .....|||. ||||||||. ||...|.. | |  ...||||||||||   .| .  |   || ||. .|.|||||||  .   . | .
cavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfye

ECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgNEKNSDFytHNSVRGCSYFYSYA
||. .| | |.. .  |||. .||. |.. . ||.||||||....|. .| | | ..||.     ||||.||     ..   |.  .. ||| || .   
ecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadp.....dqsvkdw..lanvrgvsyvfgqd

ACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
   | ... ..  . |||.  . || .. . .      |.|||||| |   ..| ||..| ..|..
vvadvisrldidlvarahqvvqdgyeffaskk......lvtifsaphycgqfdnsaaimkvdenlv
subfamily_PPPLV_pd Subfamily PPPLV 142-403 9.9e-55 178.9 In-house 9-281 (290) alignment 
Range on Protein: 142-403
Range on HMM: 9-281/290.0
GATLLRTEKTMIDIEAPVTVCGDIHGQFYDLM----KLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFK
    |  |. ......|. | ||.||.. ||.    .|. .|   . ...|||||||||| ||.| . || .||. ||  ..||||||| . ..| ...|
avdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieyk

QECKIKYSE---RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRR----LDRFKEPPAFGPMC-DLLWSDPLEDF-----GNEKNSDFYTH
 |.. |. .    |..| ...|| ||||| .... .|||.|.   |.    |      |.|.|..    |.  |.||||| ||      |.   .. . .
gegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvd

NSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
|. || .. .| .|   ||..|||  ..||||....|.|. .|..      |.|.||. .|    |. | .|  .... 
ndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgr......lltvfsssrycGssneaalilvdkkklr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 143-184 4.3e-07 22.3 In-house 24-65 (339) alignment 
Range on Protein: 143-184
Range on HMM: 24-65/339.0
ATLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPAT
  |. .|  .. .|||. | ||||||| ||. .... | | .
reliwsepiflkleapicvmgdihgqfddllamldmngwpls
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 144-402 1.3e-55 181.8 In-house 17-264 (284) alignment 
Range on Protein: 144-402
Range on HMM: 17-264/284.0
TLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIK
...  .  .|....|. .|||||||| ||..||.  | |  ..|||||||||||   .| .| |.. |. .|. .|.|||||||  . . . | .||. .
sifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrr

YSE-RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDR-FKEPPAFGPMCDLLWSDPLeDFGNEKNsdfytHNSvRGCSYFYSYAACCD
| .  || .    |  .||.||. |. ||.|||.|  .... ..| . | | .|       |.|||||  .| .  |      || || || .   |   
ynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdpt.nfqkgwn.....pns.rgvsyvfgsdalrk

FLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
.|.  ..  ..|||.  . || .. . .      |.|||||| |   ..| |||.  ..|.
lldrlqidlvvrahqvvqdgyeffanrr......lvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 144-184 3.5e-11 35.8 In-house 23-63 (317) alignment 
Range on Protein: 144-184
Range on HMM: 23-63/317.0
TLLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPAT
 |. .|. ....|||||..||||||| ||. |... | | .
elfwkeplkleleapvtivGdihGqfedllalldlnGwpls
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 145-403 5.4e-68 222.5 In-house 23-274 (284) alignment 
Range on Protein: 145-403
Range on HMM: 23-274/284.0
LLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSP------ATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQ
|. .||  ..|||||...||||||| ||. |... | |        .|||||||||||| |||| .. |...|. .|. .|||||||| | .   . | .
lfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyl

ECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFgneknsDFYtHNSVRGCSYFYSYAA
||| .|||..|.|   || ..||.|..... .|.|||.| .. .|... .|.|  . |  | ..|| |.|| ..       . | ..| ||.   .  .|
eckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaev......egy.kesprgagkvfgaka

CCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
  .||.. .|  ..|||.    || ..   .      |.|||||| |   ..| ||||. .....
vkeflkkfkldlvvrahqvvmdgyeffadrk......lvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 152-398 1e-49 162.6 In-house 2-242 (263) alignment 
Range on Protein: 152-398
Range on HMM: 2-242/263.0
MIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYS-ERVYD
.....||. .||| |||. ||...|.  |. . |.||||||||||| .|.| .. |.|||.. |. ..||||||| . . . . |. | | ..  | ||.
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

----ACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPM-CDLLWSDPledfgnEKNSDFYTHNSVRGCSYFYSYAACCDFLQN
       . |  .||.|..... ||.|||.|| .. |.||| .    |     |. |||||.||      ||..  .  | .|  |  .      |. . 
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadp......ekdakgfepnkiraisnvfgkkevddlckr

NNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY
 ..  |.|||.  . || ..   .      |||.|||  |     | |||.  
ldidlivrahqvveygyaffadrr......litvfsasryqielcnyaavvvv
Metallophos Calcineurin-like phosphoesterase 158-358 1.8e-42 138.9 Pfam-A 2-199 (200) alignment 
Range on Protein: 158-358
Range on HMM: 2-199/200.0
PVTVCGDIHGQFYDL----MKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYL--WSLKITYPQTLFLLRGNHECRHLTEYFTFKQECK----------
...|.||.||...||    ..|..|....  . .|||||.||||  |.|.  .|  ..||...|  .||||||||........ |. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------IKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIrrldrfkeppafgpmcdllwsdpledfgnek
                         ..  ...... . |..|||.|| ....|..||.||..    .||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

nsdfythnsvrgCSYFYSYAACCDFLQNNNLLSIIRAHEAQ
            .|. ... | ...|.....  ..|.|. .
............gselfgpdalekllekygvdlvlrGHtHk
PPP_4 159-358 1.3e-73 240.3 In-house 1-197 (197) alignment 
Range on Protein: 159-358
Range on HMM: 1-197/197.0
VTVCGDIHGQFYDL-MKLFEIGGSPA-TTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAF
|||.||||||..|| .||...|| |. ...|.|||||||||..|.|..|.|..||. ||....|||||||...|.....||.|.. |..........| |
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

DCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPP-AFGPMCDL-LWSDPLedfgnEKN-SdfyTHNSVRGCSYFYSYAACCDFLQNNNLLSIIR
|.||||||.....|.||||||.|...|..|.|..|..| |   . ..|| |||||      |..     ..|||||....... . ..||..||| .|||
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr.....eaqeg...lansvrGagllFgpdvtekfleknnlkliir

AHEAQ
.||..
shelk
PPP_2 159-357 1.2e-72 236.7 In-house 1-197 (198) alignment 
Range on Protein: 159-357
Range on HMM: 1-197/198.0
VTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECK-IKYSERVYDACMDAFD
||||||.|||..||..||. |......||||||||||||..|.|..|.|..||..||....|||||||.........||.|..  |....||..... |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLwsdPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEA
.||||||.....|.||||||.||..|..|.. .|..| |. |...|||   . |.. ..|...  ..||.||......  . ...|..|.|  ||||||.
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll...eeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_5_Dcr2 159-357 4.3e-69 225.5 In-house 1-198 (199) alignment 
Range on Protein: 159-357
Range on HMM: 1-198/199.0
VTVCGDIHGQFYDL-MKLFEIGGSPA-TTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIK-YSERVYDACMDA
||||||.|||..|| ..||. || |. ...|.|||||||||..|.|..|.|..||. ||....|||||||...|.|...|..|.. | .....|... | 
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPP-AFGPMCDL-LWSDPLedfgneKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIR
||.||||||.....|.|||||||||...|......|..| |   | ..|| |||||       .. . .  ||.||....... . ..||..|||  |||
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr......daqegcklnseRGagllfgpdvtekfleknnlkliir

AHEA
.||.
shel
subfamily_YNL217W_pd Subfamily YNL217W 159-240 3.3e-06 19.8 In-house 12-89 (235) alignment 
Range on Protein: 159-240
Range on HMM: 12-89/235.0
VTVCGDIHGQFYDLMKLFE--IGGSPATTKYLFLGDYVDRGYFSIECVLYLwslkitYPQTLFLLRGNHECRHLTEYFTFKQEC
. | ||.|| . .|..|..  |||       ...|| ...|  |.| | |.        .    ..||||   | .|   |.. 
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 184-402 2.8e-57 187.3 In-house 100-305 (317) alignment 
Range on Protein: 184-402
Range on HMM: 100-305/317.0
TTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHEL
  |||||||||||| |||| |. | .||..||. .|||||||| | .   . | .|.| .||...|.|   || .|||.|..|.. ||.|||.| |. .|
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

EDIRRLDRFKEPPAFGPMCDLLWSDPledfgnEKNSDFYtHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAP
. . .|.|  . |  | ..|| |.||      ... . | ..| || .  .  .|  .||.. .|  ..|||.    || ..   .      |.||||||
kqldklkrpldipdvGvladltwadp......daevkgy.kesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrk......lvtifsap

NYLDVYNNKAAVLKYENNV
.|    .| ||||. ....
sycGqldniaavlsvdkkl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 185-401 1.4e-43 142.3 In-house 120-323 (339) alignment 
Range on Protein: 185-401
Range on HMM: 120-323/339.0
TKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELE
 .||||||||||| ||.| |. | .||..||. ..||||||| | .   . | .| . .|  ..|..  . |. .|..|..|.  .|.|||.|  .  ..
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

DIRRLDRFKEPPAFGPMCDLLWSDPleDfGNEKNsdfYtHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPN
..  . |  | |  | . || |.||  |   ||    | . | ||.|. .   |   ||.. .|  .|| |.  . || ..   .      |.|||||||
qfsvfkrpleipdvgvltdltwadp..d.ptekg...y.kpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrr......lvtifsapn

YLDVYNNKAAVLKYENN
|    .| |||.  ...
ycgqndntaavfsidkk
subfamily_PPP7C_pd Subfamily PPP7C 301-403 2.4e-12 39.3 In-house 237-326 (383) alignment 
Range on Protein: 301-403
Range on HMM: 237-326/383.0
MCDLLWSDPLEDFGNeknsdfyTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
. |.||||| .. |        . |..||   ..      ..||. ||  .||.|| .  || .  ...      ..||||| || ..  |. | .|  .
vldilwsdpkakeGc.......kpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkk......vltifsasnyyeeGsnrGayvklgk

NVM
...
dlt