Gene PpD3 in Drosophila melanogaster

Synonym: CG8402, D3, DmPP5, DmPpp5-85E, Dmel\CG8402, PP5, PP5 85E, Pp5-85E, Dmel_CG8402, PpD3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP5C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP101_AA protein Get Run
DmelP101_AA_190-515 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
TPR_11 TPR repeat 49-114 7.1e-19 56.9 Pfam-A 3-69 (69) alignment 
Range on Protein: 49-114
Range on HMM: 3-69/69.0
AEQYKNQGNEMLKTKEFSKAIDMYTKAIELHPNSAIYYANRSLAHLRQE-SFGFALQDGVSAVKADP
||..|..||. .| ... .||..|.||.|| ||.|..|.|..||.|..   .  ||.|   |.. ||
AealkelGnalfkegdydeAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_1 Tetratricopeptide repeat 49-81 6.6e-09 24.8 Pfam-A 1-33 (34) alignment 
Range on Protein: 49-81
Range on HMM: 1-33/34.0
AEQYKNQGNEMLKTKEFSKAIDMYTKAIELHPN
|. ..| ||  || ... .|.. | ||.|| ||
akalynlGnaylklgkydeAleyyekALelnPn
TPR_2 Tetratricopeptide repeat 49-81 4.2e-07 19.3 Pfam-A 1-33 (34) alignment 
Range on Protein: 49-81
Range on HMM: 1-33/34.0
AEQYKNQGNEMLKTKEFSKAIDMYTKAIELHPN
|| . |.|.  .| ... .|.. . ||.|| ||
aealynlGlayyklgdyeeAleafekAleldPn
TPR_16 Tetratricopeptide repeat 55-115 8.4e-06 16.0 Pfam-A 3-63 (65) alignment 
Range on Protein: 55-115
Range on HMM: 3-63/65.0
QGNEMLKTKEFSKAIDMYTKAIELHPNSAIYYANRSLAHLRQESFGFALQDGVSAVKADPA
.... |. ... .|.. . .|..|.|  | .. ..  |.|||  .  |..   .|....| 
lArallraGdydeAlaaleaalalaPeaaeallllaeallrqgrldaAaallraalalaPd
TPR_17 Tetratricopeptide repeat 71-96 8.6e-07 18.6 Pfam-A 1-26 (34) alignment 
Range on Protein: 71-96
Range on HMM: 1-26/34.0
MYTKAIELHPNSAIYYANRSLAHLRQ
.|.||.||.||.| .| |. ...|..
lyekalelnPnnadaynnLAelllnn
TPR_9 Tetratricopeptide repeat 92-154 4.6e-06 15.9 Pfam-A 4-66 (73) alignment 
Range on Protein: 92-154
Range on HMM: 4-66/73.0
AHLRQESFGFALQDGVSAVKADPAYLKGYYRRAAAHMSLGKFKQALCDFEFVAKCRPNDKDAK
..||.| |  ||.   . .  .|  .  .. |. ... || . .|| |.|. ..  |.. || 
iylreedferALavverllllaPddpyerRDrGlllaqlgclaaAledLeaflelcpdapdae
TPR_11 TPR repeat 109-147 2.4e-07 19.9 Pfam-A 29-68 (69) alignment 
Range on Protein: 109-147
Range on HMM: 29-68/69.0
AVKADPAYLKGYYRRAAAHMSLG-KFKQALCDFEFVAKCR
|.. || . . ||..|.|.. || ....|| |.| . . .
AleldpnnaelyynlAlaylklgkdyeeAledyekAleld
TPR_1 Tetratricopeptide repeat 118-149 2.4e-06 16.6 Pfam-A 2-33 (34) alignment 
Range on Protein: 118-149
Range on HMM: 2-33/34.0
KGYYRRAAAHMSLGKFKQALCDFEFVAKCRPN
| .|....|...|||...|| ..| . . .||
kalynlGnaylklgkydeAleyyekALelnPn
PPP5 PPP5 TPR repeat region 156-251 4.6e-41 129.2 Pfam-A 1-95 (95) alignment 
Range on Protein: 156-251
Range on HMM: 1-95/95.0
KFTECNKIVKMRAFERAIAVDKPEKTLSEMYsDMENITIEDDYKGPQLEDGKVTLKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDI
|..||.|.||..|||.||.||. ... .|.. |.|.|.|||||.||.|||.||||.|.|||.|..|.||.||.||.|.||..........||||.|
KlkeCeklvkkiaFekAIevdeekrsvaesi.diesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpslvei
0045823 Metallo-dependent phosphatases 191-515 3.8e-106 348.5 In-house 9-338 (473) alignment 
Range on Protein: 191-515
Range on HMM: 9-338/473.0
NITIEDDYKGPQLEDGKvTLKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVpdeeKFTICGDIHGQFYDLMNIFEINGLPSEkNPYLF
.|.. . . .| | . . .| ....|.||.| ...|. ....|.| |.  ... .|.|....     .....||||||..||....|..|.|.| . ..|
lipvlrlltlpllfill.glldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drlvf

NGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEdVTLDHIRR
.||.||||..|.|..  |. .|..||...|| |||||. ..|..||| .|. .||.  . . | .....|||.. |..|||..||||..    .|| ||.
lGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdl.plldqire

IERNCQPPEEGLMCELLWSDPQQWMG--------LGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGK------CITVFSAPNYCDT
||| ...|..||...||||||.  .|         | |.||.| .||||..|.|.|.|.||.|.|.|.. ..|||. ..||      .||||||||||..
ierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgr

MGNMGAFITITGNNlkPNYKSFEAVPHPDVKPMAYANSL
.|| .|...|...   .... |...||| ..|... . |
ggnlaAvlvidedl..isfiqfdpsphplilplfldvfl
subfamily_PPP5C_pd Subfamily PPP5C 193-514 4.4e-187 613.7 In-house 1-322 (322) alignment 
Range on Protein: 193-514
Range on HMM: 1-322/322.0
TIEDDYKGPQLEDGKVTLKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPDEEKFTICGDIHGQFYDLMNIFEINGLPSEKNPYLFNG
|.||.|.||.||..|.| .|.|||.|..|.||.||.|.|.|||.|........||||.||.....|.|.|||||||||||.||||.||||||.|||||||
tvedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnG

DFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDVTLDHIRRIE
|||||||||||.|.||.||||||||||||.||||||.|||..|||.|||.||||...||.||.|||||||.|.||.|.||.||||||...||||..|.|.
dfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkid

RNCQPPEEGLMCELLWSDPQQWMGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGNNLK
||.|||||||..||||||||...|...||||||.|||||||.||.|.|||..||||||||..||||.|.||.|||||||||||.|||.|||||..|..||
rnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlk

PNYKSFEAVPHPDVKPMAYANS
...|.||||.||||||||||||
lkfktfeavehpdvkpmayans
subfamily_PPP7C_pd Subfamily PPP7C 194-394 3e-62 203.5 In-house 2-202 (383) alignment 
Range on Protein: 194-394
Range on HMM: 2-202/383.0
IEDDYKGPQLEDgKVTLKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPDEEKFTICGDIHGQFYDLMNIFEINGLPSEKNPYLFNGD
.||.|.||.|.   .|.. ...|.|..| .|.|| |.  .|| |    ... |..  ..    .. |.|||.||.. ||. |.  ||||||.|||.||||
vedsytgprlsl.pltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

FVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYT---SAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDvtLDHIRR
|||||. ||| .. |. . |.||....| |||||   .|  |||. ||. ||    . .  .. .|| ||||.  |..|||..|||.  . |  |. . .
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd..lelldk

IERN
|||.
iers
0053225 Metallo-dependent phosphatases 207-502 1.1e-89 293.7 In-house 3-292 (293) alignment 
Range on Protein: 207-502
Range on HMM: 3-292/293.0
KVTLKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITvpdeEKFTICGDIHGQFYDLMNIFEINGLPSEkNPYLFNGDFVDRGSFSVECIF
...| ... |.|... .|.|. ......| |. .... .|.|....     .....|||||...||....|. |.|.| . ..|.||.||||..|.|.. 
slilllldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevle

TLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKY-TSAMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCE
 |. .|||||....| |||||. ..|..||| .|. .||  ... | .......|||.. |..|||..|||| | . ..||.||.|.| ...|.|||...
lllalkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGl.spdlslldqireinrplriplegllld

LLWSDPQQWMGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGNnLKPNYKSFEAVP
||||||. |.| ..|.||.|. ||......|.| |.||.|||.|.| . ||.. ..||..||||||||....||.||.... .. |....| |..|.
llwsdpdlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeg.lvwgfklfapvl
0049330 Metallo-dependent phosphatases 208-507 9.1e-96 313.5 In-house 12-305 (309) alignment 
Range on Protein: 208-507
Range on HMM: 12-305/309.0
VTLKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITvpdeEKFTICGDIHGQFYDLMNIFEINGLPSEkNPYLFNGDFVDRGSFSVECIFT
..|.....|.|... .|.|. ......| .. .... .|.|....     .....||||||..||....|..|.|.| . ..|.||.||||..|.|.. .
lilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpdslevlll

LFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEdVTLDHIRRIERNCQPPEEGLMCELL
|. .|||||...|| |||||. ..|..||| .|. .|| . . . |......|||.. |..|||..||||..   ..||.||..|| ...|..||.|.||
llalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdl.llldqirelerpleipldgllcdll

WSDPQ-QWMGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITItGNNLKPNYKSFEAVPHPDV
||||.    |.....||.|. ||....|.|.| |.||.|||.|.. . ||.. ..||.||||||||||...||.||...| ...|..... ||.||.. .
wsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavlei.dedlvisfllfepvpllll

K
.
l
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 211-488 3.6e-80 262.2 In-house 9-282 (298) alignment 
Range on Protein: 211-488
Range on HMM: 9-282/298.0
KFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSEKNpYLFNGDFVDRGSFSVECIFTLFG
....  ... |  | .. .   |.. .    ...|.|||..  |     ..|||||||. ||. .|. .| | ..| ||| ||.||||....| |  |. 
evlsvslsekkltkvikeedveklielakkifkkqkslvevdap....ikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnlevivllla

FKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKY-TSAMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWS
.|. |||.||| |||||   .|..|||  |.. .|   ..   | .|||.|||.  | ..|| ||||| | . ..||..|...|  ...|| |  .|||.
ykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGl.skklksldqlrelkrpfdskeeslaidllwa

DPQQW-MGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITG
||...  |  ...|||...|| || ...... ..| ..|.| |   |||   . | .|.||||.||. . |  |....  
dpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvde
subfamily_PPP3C_pd Subfamily PPP3C 213-508 2.5e-79 260.2 In-house 28-329 (452) alignment 
Range on Protein: 213-508
Range on HMM: 28-329/452.0
MKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSEKNpYLFNGDFVDRGSFSVECIFTLFGFK
.. | ||.... ||... | ||. |  . .. ...|...  |     |..||||||||||...||..| |.. . ||| ||.||||.||.||.. |.  |
levlkehflkegrleeeaalkiieeaakllkkektlleveaP....itviGdihGqfydllklfevgGdPastk.ylflGdyvdrGyfsiecvlylyalk

LLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQ
. ||...|| |||||.  . . . |  |.. ||. .. | ... |. |||   .||. | .|||| |.|  .|| |....|  .||. |..|.|||||| 
iaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGl.speikslddikkldrfkeppasGplcdllWsdPl

QWMGLGQ--------SKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHN------GKCITVFSAPNYCDTMGNMGAFITITGNNLkpNYKSF
.  |  .        | ||  . ..   . .| ..|.|  |||.||..| ||.. ..         ||.||||||.|.  | .| . .  |..  | . |
edygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm..nirqf

EAVPHPDVKP
...|||   |
nssphpywlp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 213-487 4.8e-65 212.4 In-house 3-276 (290) alignment 
Range on Protein: 213-487
Range on HMM: 3-276/290.0
MKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSEkNPYLFNGDFVDRGSFSVECIFTLFGFK
| | ...| . . .  |  ..|| .|.  ..  |.|...  |     .| ||||||. .|.. |.  | | .   .|| ||.||||. |.|    || .|
miehllkygvldafsdkdileilekieeileplpalleveap....ivivgdihgqldallryfdavgyppk.vkflflgdyvdrgakslevslllfcyk

LLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQ--PPEEGLMCELLWSD
..|...  | |||||  ..|..|||  |.. | .| .   . .||. |.||  ...||| ||||. | .  . . .. ...       .|||. .|||.|
iryskkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggi.sqkiesweslkalkkprvpltcdeglqvdllwad

PQQ--WMGLG-QSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITIT
|..     .  . .|.. . || .. ....|   |. |.|.||||. |..   . |..|||||| |.    |.|| .|..
ptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvs
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 220-487 4e-69 225.7 In-house 4-269 (287) alignment 
Range on Protein: 220-487
Range on HMM: 4-269/287.0
YKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSeKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHF
| . . .  |  ...| .|.  ..  |.|.... |     ||.||||||. ||..||.  | .. |  ||| ||.||||. |.| .. || .|..||.. 
ygvldafsdkdilevlekieeileplpalleveap....itivGdihGqlddllrifnavGaap.kvqylflGdyvdrGakslevslllfslkiaypkkv

FLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPP--EEGLMCELLWSDPQQWM-G
 | |||||  ..|..|||  |.. |. . .   | .||. ||||  ....|| ||||. | .  .|| .. ...  .|   .|||. .|||.||..   .
hllrGnhevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGi.spklksldslkalkkpttplacdeglqvdllwadpekdakt

LGQS-KRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITIT
.     |..   ||  . ....|  ..| |.|.|||.. ||.   . ...|||||| |.    |.|| ....
felnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvs
PP2Ac_SM00156 227-499 2.8e-102 334.4 In-house 2-268 (271) alignment 
Range on Protein: 227-499
Range on HMM: 2-268/271.0
HRKFAYKILCEIDTYMRAQPSLVDITvpdeEKFTICGDIHGQFYDLMNIFEINGlPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNH
... ....| |... ......||...    .. |..||||||..||....| .| ......|.|.||.||||..|.|.| .|| .|.|||....| ||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

ESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFStEDVTLDHIRRIERNCQPPEEGLMCELLWSDP-QQWMGLGQSKRGVG
|| ..|..|||. || .||.. . ..|...|..|||. ....|||.||||| . |  .||.||...|. ..|||||...|||||| |. .|. .||||..
EsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp.eleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrgls

IQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITItGNNLKPNYKSFE
..||.|....|.| |||..|||.|||.| |||. ...|..|.|||||||| ..|..|....  .|||.......
vvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkv.eknlklsieqlk
PPP_3 229-490 1.2e-98 322.5 In-house 5-262 (271) alignment 
Range on Protein: 229-490
Range on HMM: 5-262/271.0
KFAYKILCEIDTYMRAQPSLVDITvpdeEKFTICGDIHGQFYDLMNIFEiNGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHES
. ..... ..   .  ...||.|.    .. |.|||||||..||...|. ||.||... |||.||.||||..|.|....|. .|..||....| ||||||
nelkelvkklkeilekesnlveis....apvtvcGDiHGqldDLlelfk.nggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEs

INMNQMYGFTGEVT-AKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDvTLDHIRRIERNCQPPEEGLMCEL-LWSDPQQWMGLGQSKRGVGI
 ..|..|||. ||.  |... . . ...||..|||...|..|.||.||||... . .||.|...||... ||||....| |.|||..  ||..||||.|.
rqinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsik.sldqikklerkievpeegklldlllssdpekeeglenskrGagl

QFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGNN
 |||||||.|...|.|..|||.||.|. |||. |.||..|||||||||....|.||..... ..
lFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleeal
subfamily_PPP1C_pd Subfamily PPP1C 232-489 3.4e-85 278.6 In-house 16-268 (282) alignment 
Range on Protein: 232-489
Range on HMM: 16-268/282.0
YKILCEIDTYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSEKNpYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINM
 ..| .  . . .|| |.... |     .|.||||||..||...||..| |.|.| ||| ||.||||..|.| |  |. .|. ||...|| |||||| ..
eallkkareillsqpilleleaP....vkivgdihGqyadllrlfetsgaPpesn.ylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasi

NQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQQ-WMGLGQSKRGVGIQFGP
|..|||  |.  .|.. .  .||.|||.|||.  ...|||..|||| |.|   |..||.|.| .. ||.||.|.||||||..  .|.....||| ..||.
nriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGl.spelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfgk

DVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGN
|| |||...|.|| |.|.|.| . |||   . . .|||||||||....|.|| .... .
dvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdee
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 232-489 2.1e-46 151.5 In-house 13-290 (302) alignment 
Range on Protein: 232-489
Range on HMM: 13-290/302.0
YKILCEIDTYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPS----------EKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFL
.... ..   .. . .|..|. |     || ||||||| ||. |.  .               .. ..| ||.||||| |.|||  .| .|.|||... |
lllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyil

ARGNHESINMNQMYGFTGEVTAKYTSAM----ADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEE-GLMCELLWSDPQQWMG
 |||||.  .|  ||| .|.  ... .      . | .|| ..||   . .||| .|||. |    .|..|..|.|  .   |  |  .||..|| .  .
lrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkikrplkevtedslaqdllfadpldvql

LG----------QSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGN
|             .||. . |     ...||  ||. |.|.| .  .|.    . | .|.||||.| . . | || . . .|
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_PPP2C_pd Subfamily PPP2C 233-503 2.3e-76 249.8 In-house 23-288 (290) alignment 
Range on Protein: 233-503
Range on HMM: 23-288/290.0
KILCEIDTYMR-AQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSEKNpYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINM
| |||    .   .  . .. .|     |.|||.||||.||...| | |   . | ||| ||.|||| .|||..  |  .|. |..   . |||||| ..
kelcekakeilskesnvqevkcp....vtvcgdvhgqfhdllelfkiggkspdtn.ylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqi

NQMYGFTGEVTAKYTSA-MADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQQWMGLGQSKRGVGIQFGP
 |.||| .|.  ||..| .  .||..|..|||.  ....|...|||| | .  |||.|| ..|  . |.|| .|.||||||..  |.| |.|| | .|| 
tqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhggl.spsidtldkiraldrlqevphegplcdllwsdpddrggwgisprgagytfgk

DVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITgNNLKPNYKSFEAVPH
|..||| | |.| .|.|.|..   ||...|. . .|.|||||||   ||..| . .  ..|| ..  |.. |.
disekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaaileld.dklkysflqfdpapr
subfamily_PPP6C_pd Subfamily PPP6C 233-503 1.6e-72 237.1 In-house 21-286 (290) alignment 
Range on Protein: 233-503
Range on HMM: 21-286/290.0
KILCEIDTYMRAQPSLVditVPDEEKFTICGDIHGQFYDLMNIFEINGLPSEKnPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMN
| ||.. . .  . | |   .| .   |.|||||||||||...|   |   ..  |.| ||||||| .|.| .  |. .|. ||..  | |||||| .. 
kklcdlvldllleesnv...qpvsspvtvcgdihgqfydleelfrtggqvpdt.syvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqit

QMYGFTGEVTAKYTSAMAD-IFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQQWMGLGQSKRGVGIQFGPD
|.|||  | . || .| |   .|.||. |...  |....| .|||| |..  |||.|| |||. . |..| .|.|.||||..     .|.|| |  ||  
qvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGgl.spdvktldqirvieraqeiphkgafcdlvwsdpedvetwavsprgagylfgsk

VTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGNNlKPNYKSFEAVPH
||..|.. |||. |.|.|.. . |..   . | .||.||||||   ||. . ...  .. . . | |.|||.
vtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae.ereaklfkavpd
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 233-488 2.3e-66 216.9 In-house 15-265 (281) alignment 
Range on Protein: 233-488
Range on HMM: 15-265/281.0
KILCEIDTYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSEKNpYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMN
... |... .  . .||.|  |     .. ||.|.|| || ..||. | ..|.  ..| ||.||||  |.|... || .|. |... .| |||||  ..|
nvireveaifseekaLveidkP....ivvvGdlhaqfndlkrlfellgrvpeev.lvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

QMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQQ-WMGLGQSKRGVGIQFGPD
..|||  |   ||   .   | . || ||.   |....|.||||| | | ..||..| . . ..... ||. .|||.||..  ..  .| ||..  || .
kiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGl.sPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGkn

VTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITG
| .. ||  ....|||.| |   ||||    | |||||.||||.   | .| ...  
vvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvde
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 233-485 6.6e-52 169.6 In-house 27-277 (307) alignment 
Range on Protein: 233-485
Range on HMM: 27-277/307.0
KILCEIDTYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSEKnPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMN
... | .| . .. .||||  |      . ||.|||| ||.|.| . | | |   |.| ||.|||| .|.|||. || .|. ||..  | |||||   .|
nviyeaqtifssekalvdidpp....cvvvgdlhgqfndlinmfillgrppet.vyvftgdyvdrgllslecilllftykicypenivllrgnheiarvn

QMYGFTGEVTA---KYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQQW-MGLGQSKRGVGIQF
. |||  |. .   |    .  .| ..|| ||.   |  |||.||||| |     || .|   .  . |  |.. ..||.||.   .    | || |. |
kkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhggl.spaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftf

GPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFIT
| .| .  ||   .. |||.|..   || |    | ||.|||| ||.   | |. . 
gtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlk
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 233-489 1.7e-46 151.8 In-house 13-289 (302) alignment 
Range on Protein: 233-489
Range on HMM: 13-289/302.0
KILCEIDTYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPS----------EKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLA
... ..   .. . .|..|. |     || ||||||| ||. |.  .               .. ..| ||.||||| |.|||  .| .|.|||... | 
llieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHESINMNQMYGFTGEVTAKYTSAM----ADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEE-GLMCELLWSDPQQWMGL
|||||.  .|  ||| .|.  ... .      . | .|| ..||   . .||| .|||. |    .|..|..|.|  .   |  |  .||..|| .  .|
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkikrplkevtedslaqdllfadpldvqll

G----------QSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGN
             .||. . |     ...||  ||. |.|.| .  .|.    . | .|.||||.| . . | || . . .|
aavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 235-489 6.5e-67 218.9 In-house 32-283 (299) alignment 
Range on Protein: 235-489
Range on HMM: 32-283/299.0
LCEID-TYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSEKNpYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQ
||..  . .  |.||...  |      .|||||||. ||. ||...|.| . | .|| ||.||||   .| |  |. ||. ||..||. |||||   .|.
lcavaksvfasqaslleveap....iivcgdihgqysdllrifdkagfppdvn.flflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainr

MYGFTGEVTAKYTSA-MADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQQWM-GLGQSKRGVGIQFGPD
.|||  |.  .|.|. .  || . |...||.  |. .||.||||| | .  ||| .| . |  .||.  |  .|||.||.|.. .     |||   ||.|
vygfyeecnkrykstrlwsifqdafaampltgligsrilcmhggl.spklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvfgqd

VTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGN
| .. ..  ..| . |.|.| . |||   . | .|.|||| ||  . |  | . .  |
vvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvden
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 236-487 2.7e-71 233.0 In-house 16-262 (280) alignment 
Range on Protein: 236-487
Range on HMM: 16-262/280.0
CEIDTYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSEKNpYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMY
 .    . || ..|..  |     ..|||.|||. ||. .|.  ..| ..| ||| ||.||||.. .| |  |. .|. |||.|.. ||||| |..|. |
ekckkiltaqatmvevdap....vavcgdlhgqytdllrlfarvsfppdqn.ylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrky

GFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQ-QWMGLGQSKRGVGIQFGPDVTE
||  ||  .|. |. . | .... |||.  .. .||.||||| | . |.||..... |  ....| |  .|||.||. .  | ... ||| ..|| .|  
gfkdevkrryslalynefqelldslplvalvsgrilcmhggl.sqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvk

KFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITIT
....  ..| |.| |.| . |||   . | .||||||.|.. . |  | . . 
dltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivd
PPP_1 237-485 1e-93 306.4 In-house 8-263 (264) alignment 
Range on Protein: 237-485
Range on HMM: 8-263/264.0
EIDTYMRAQPSLVDITVPDEEKFTICGDIHGQFYDLmNIFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYG
|. . ..  ..  ....  .|. |.||||||||.|| ...  .|.||... |||.||.||||..|||....|. .|| ||...|| |||||| .....||
elkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvyg

FTGEVT-AKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDvTLDHIRRIERNCQPPEEGLMCEL--------LWSDPQQWMGLGQSKRGVGIQ
|. ||   ||.. . ...|.||..|||. .|..|||..|||| .. | .||.||...|. . |||| .|.|        |..|..| ..  .|.||.| .
FkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeld.lldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagyl

FGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFIT
||.||||||.. |||..|||.||||. |||.....|..|.|||.||.....|.||...
fgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 240-486 1.8e-66 217.4 In-house 37-281 (297) alignment 
Range on Protein: 240-486
Range on HMM: 37-281/297.0
TYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSEKNpYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTG
  ..|| |.|..  |      .|||||||| ||. .|   | |   | ||| ||.|||| ||.| |  |. .|. .|  .|| |||||   .|..|||  
dvfkaqksmvevnap....ikvcgdihgqfpdllrlfhrggwpptan.ylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfye

EVTAKYTSA-MADIFTQVFNWLPLCHCINQKILVMHGGLFS--TEDVTLDHIRRIERNCQpPEEGLMCELLWSDPQQ-WMGLGQSKRGVGIQFGPDVTEK
|.  .| |  |   | .|||||||.  | .|||.|||||    |...||| .|.|||. .  .|.|...|||.||     |. . .|| |  || |   |
ecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisglsgfmenqrgagcgfgrdavlk

FCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITI
 | . .|| . |.|.| . |||.    | .|.|||| ||  . |  ||.. 
lcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmsc
subfamily_PPZ_pd Subfamily PPZ 240-488 8e-55 179.5 In-house 39-282 (300) alignment 
Range on Protein: 240-488
Range on HMM: 39-282/300.0
TYMRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSEKNpYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTG
  . |||.|.... .      | ||.|||. ||. .|   |.|   | ||| ||.||||  |.| |. |. .|. ||. ||| |||||  |. ..|||  
elflaqpallelsps....vkivgdvhgqyadllrlftkcgfppsan.ylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfyd

EVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTeDVTLDHIRRIERNCQPPEEGLMCELLWSDPQQWM-GLGQSKRGVGIQFGPDVTEKFCK
|.  .    .   | . || |||.  .  ||...||||      ..| ||.. |  . |. ||. .|||||| .      . .|||   .     .|| .
eckrrcnikiwktfvdtfntlplaaivagkifcvhgglspv.lnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynkvainkfln

DNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITG
   .| . |.| | . |||.  .   .|||||||||  . | || .... 
kfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvse
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 242-489 6e-58 189.5 In-house 19-263 (284) alignment 
Range on Protein: 242-489
Range on HMM: 19-263/284.0
MRAQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLPSEKNpYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEV
.  || |...  |      ||||||||| ||. .|. ||.|   | ||| ||.||||   .| |. || .|...|||||. |||||   .|..|||  |.
fnkqpmlievnsp....inicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeec

TAKYTS-AMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEE-GLMCELLWSDPQQW-MGLGQSKRGVGIQFGPDVTEKFCK
  .|   ..   |  ||  .||   . |.||.||||. |     . ..| |.|  . ||   |  ..||||| ..  |     |||   || |   |.  
qrrynkpsvyvsfegvfsvmpltalvgqrilcmhggv.skmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklld

DNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGN
  ..| ..|.|.| . |||.  | . .|.|||| ||  . |  | . .  |
rlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnkn
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 244-488 1.5e-70 230.9 In-house 26-271 (284) alignment 
Range on Protein: 244-488
Range on HMM: 26-271/284.0
AQPSLVDITVPdeekFTICGDIHGQFYDLMNIFEINGLP-----SEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFT
 ..  ..| .|     .|.||||||| ||. ....|| |     .... ||| ||.|||| ||.| |  || .|||.|.. || ||||||  .|. ||| 
keklkleieap....vkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfy

GEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQQW-MGLGQSKRGVGIQFGPDVTEKFC
 |   .|. |. ..|   || .|||  ...||. ||||. | . . |. . ..|| .. |. |....| |.||..  .|  .|.|| |  ||..  ..|.
leckkrysealyeafqlafnamplcavvskkiicmhggi.sedlldlkqldklerpidipdigviadltwadpeaevegykesprgagkvfgakavkefl

KDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITG
|  .|| ..|.|.|   |||   . | .|.|||| ||  . |..| ...  
kkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvde
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 256-283 4.3e-08 25.7 In-house 35-62 (317) alignment 
Range on Protein: 256-283
Range on HMM: 35-62/317.0
EEKFTICGDIHGQFYDLMNIFEINGLPS
|   ||.||||||| ||. ....|| | 
eapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 257-504 5.5e-57 186.4 In-house 33-278 (280) alignment 
Range on Protein: 257-504
Range on HMM: 33-278/280.0
EKFTICGDIHGQFYDLMNIFEINGL-PSEKnpYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQ
    . |||| |. |.  .|.. |  | ||   .| ||.||||   .| .  || .|. | .. .| |||||. ..|..|||  |.  ||  ..   |  
apikvigdihaqyqdmnrlfdligrvpeek..lmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygvglwwdfqs

VFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQQ-WMGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDM
.|| .|..  |....|.||||| | | . || || | | |.| . ||. .|||||| .   |  .| ||.   ||  | |. ||  ..| |||.|.| . 
cfnrmpmsgliskrvlcmhggl.spelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqd

GYEVAHNGKCITVFSAPNYCDTMGNMGAFITITgNNLKPNYKSFEAVPHP
|||.    . ||||| ||||  . |  | . .   ||. ... .   | |
gyemmagrrlitvfsvpnycaqftnaaavvcln.anlqvsfqqlippplp
subfamily_PPP4C_pd Subfamily PPP4C 258-502 3.8e-77 252.3 In-house 44-286 (288) alignment 
Range on Protein: 258-502
Range on HMM: 44-286/288.0
KFTICGDIHGQFYDLMNIFEINGLPSEKNpYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAM-ADIFTQV
  |.|||||||||||...|...|   |.| ||| ||||||| .|||... |  .|. ||..  | |||||| .. |.|||  |.  || ||      |.|
pvtvcgdihgqfydllelfkvggdvpetn.ylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfydeclrkygsanvwryctev

FNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQQWMGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGY
|..|.|.  |..||...|||| | .  |||.|| |.|. . |.|| .|.||||||..  | . | || |  || ||.|.|...|... |.|.|..   ||
fdylslaaiidgkifcvhggl.spsistldeirsidrkqevphegplcdllwsdpedaegwavsprgagylfgsdvveqfneandielicrahqlvmegy

EVAHNGKCITVFSAPNYCDTMGNMGAFITItGNNLKPNYKSFEAVP
 .  | | .||.||||||   ||. | . .  ..|. ..| |||..
klhfnekvltvwsapnycyrcgnvaailel.deeldkdfkifeaaa
Metallophos Calcineurin-like phosphoesterase 258-452 3.8e-45 147.6 Pfam-A 2-199 (200) alignment 
Range on Protein: 258-452
Range on HMM: 2-199/200.0
KFTICGDIHGQFYDL---MNIFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTL--FGFKLLYPNHFFLARGNHESINMNQMYGFTGEVT----------
.....||.||...||   ..|.. .. ... ...||.||.||||  | |..  |  .  |||.|...||.|||||| ..|. |||. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------AKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDVTLDHirrierncqppeeglmcellwsdpqqwmglg
                         ...   .. . ..|..|||.. ...|||..||.|.|... ..|.                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

qskrgVGIQFGPDVTEKFCKDNNLDYIIRSHEVK
      .  ||||..||.......|...|.|. |
.....gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPG1_pd Subfamily PPG1 259-502 1.3e-63 208.0 In-house 43-297 (300) alignment 
Range on Protein: 259-502
Range on HMM: 43-297/300.0
FTICGDIHGQFYDLMNIFEINGLPSEKNpYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKY--TSAMADIFTQV
 |. ||.||||||...||.| |   . | ||| ||.|||| .||| |  |  .|| ||    | |||||| .. |.||| .|.  ||   | . . .|..
vtvvgdvhgqfydvleifkiggqvpdtn.ylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggnsrvwkyltei

FNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPPEEGLMCELLWSDPQ----------QWMG--LGQSKRGVGIQFGPDVTEKFCKDNNLDY
|..| |.  |...| ..|||| | .  ..| |. ..|  . |.|| ...||||||.          .  |  . .|.|| |  .| ||.||| . |... 
fdylvlaaiideeiycvhggl.spsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnr

IIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITgNNLKPNYKSFEAVP
|||.|..   ||..  ..|  ||.||||||   ||. . . .  ....  .. .|. |
iirahqlcnegyqilfdnklstvwsapnycyrcgnkasilely.ekderyfnvyeeap
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 259-486 9.2e-47 152.9 In-house 9-242 (263) alignment 
Range on Protein: 259-486
Range on HMM: 9-242/263.0
FTICGDIHGQFYDLMNIFEINGLpSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTS-----AMADIF
  |||| |||. ||. ||.  |  . |  ||| ||.|||| .|.| |. || .||  | ...| |||||   .|. |||  |.  ..       .. . |
inicgdthgqyndllrifnacga.atktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynhf

TQVFNWLPLCHCINQKILVMHGGLfSTEDVTLDHIRRIERNCQPP-EEGLMCELLWSDPQQW-MGLGQSK-RGVGIQFGPDVTEKFCKDNNLDYIIRSHE
 |||...|||  ....||.||||. |    .|| || |    .      | |.|||.||..   |.   | | .   ||    . .||  ..| |.|.|.
nqvfsymplcaivskrilcmhggi.sphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahq

VKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITI
| . || .  . . ||||||  |   . |  | . .
vveygyaffadrrlitvfsasryqielcnyaavvvv
PPP_4 260-452 4.7e-76 248.2 In-house 2-197 (197) alignment 
Range on Protein: 260-452
Range on HMM: 2-197/197.0
TICGDIHGQFYDL-MNIFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFN
|..||||||..|| ...... |||||.. |.|.||.||||..|.|.. .|. .|| ||....| |||||| ..|..|||. ||. |... . .....||.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

WLPLCHCINQKILVMHGGLFSTEDvTLDHIRRIERNCQPP-EEGLMCEL-LWSDPQ-QWMGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVK
.|||...|..|.||.||||... . .||.|.||||... | ||.....| |||||. .  || .|.||.|. |||||||||...|||..||||||.|
llplaalidekvlvvhgglsdele.sldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshelk
PPP_2 260-452 6e-74 241.0 In-house 2-198 (198) alignment 
Range on Protein: 260-452
Range on HMM: 2-198/198.0
TICGDIHGQFYDLMNIFEiNGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVT-AKYTSAMADIFTQVFN
|.|||.|||..||...|. |||||... |||.||.||||..|.|....|. .|| ||....| |||||| ..|..|||. ||.  |..... . ...||.
tvcGDlHGqldDLlilfk.nglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

WLPLCHCINQKILVMHGGLFSTEDvTLDHIRRIERNCQPPEEGLMCEL-----LWSDPQQWMGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVK
.|||...|..|.||.||||... . .||.|...||... ||||....|     |......  .| .|.||.|. |||||||.....|.|..|||.||||
lLplaalidekvlvvHGGlseeik.lldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHevk
PPP_5_Dcr2 260-452 7.5e-72 234.5 In-house 2-199 (199) alignment 
Range on Protein: 260-452
Range on HMM: 2-199/199.0
TICGDIHGQFYDLMNIFEING-LPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAK-YTSAMADIFTQVF
|.|||.|||..||. |.. .| .|||.. |.|.||.||||..|.|.. .|. .||.||....| |||||. ..|..|||| ||  | . . . .|...||
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NWLPLCHCINQKILVMHGGLFSTEDvTLDHIRRIERNCQPP-EEGLMCEL-LWSDPQ-QWMG-LGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVK
.||||...|..|.||.||||... . .......|||... | |.| ...| |||||. .  |   .|.||.|. |||||||||...|||..||||||.|
dwlPlaalidekvlvvhgglspeik.siellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_PPPLV_pd Subfamily PPPLV 260-489 1.9e-41 135.3 In-house 27-278 (290) alignment 
Range on Protein: 260-489
Range on HMM: 27-278/290.0
TICGDIHGQFYDLMN---IFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAMAD---IF
 . ||.||.. ||.     .   |       .|| ||.|||| |||| |  |.  |.||| ...| |||||   . . . . || . |.   . .    |
yvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevweaf

TQVFNWLPLCHCINQKILVMHGGLFS--TEDVTLDHIRRIERNCQPPEEG--LMCELLWSDPQQW-----MG--------LGQSKRGVGIQFGPDVTEKF
..||..|||   |..|.. .|.|.      .  .  |. |  . . . .|  |  ..|||||..      .|        .  ..|| |  |. |  |.|
nnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleaf

CKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTmGNMGAFITITGN
 | |||....|.||||. |... ..|. .||||. .|| .  |  | | .  .
lkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 286-488 3.5e-62 203.4 In-house 101-303 (317) alignment 
Range on Protein: 286-488
Range on HMM: 101-303/317.0
NPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTL
. ||| ||.|||| ||.| .  || .|||||.. || |||||| ..|. |||  ||. .| .|. ..| ..|| ||||  .|.||| ||||. | | . |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGi.seelldl

DHIRRIERNCQPPEEGLMCELLWSDPQQ-WMGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFI
. . ...| .. |. |....| |.||..   |  .|.|| |  ||..  ..|.|  .|| ..|.|.|   |||   . | .|.||||.||  . |..| .
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

TITG
..  
svdk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 287-487 6.1e-47 153.4 In-house 121-321 (339) alignment 
Range on Protein: 287-487
Range on HMM: 121-321/339.0
PYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLfSTEDVTLD
 ||| ||.|||| ||.| .  |  .|| ||.. .| ||||||  .|  |||  ||  .| . . . | ..|| .|.|  ||. |..||||. |    ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggi.sehltsfn

HIRRIERNCQPPEEGLMCELLWSDPQQ-WMGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFIT
..  ..|  . |. |.. .| |.||.    |   | ||  . |||     | |  .|. .|| |.| . |||.    . .|.|||||||    |  | ..
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

IT
| 
id
subfamily_PPP7C_pd Subfamily PPP7C 403-499 4e-28 91.2 In-house 237-333 (383) alignment 
Range on Protein: 403-499
Range on HMM: 237-333/383.0
MCELLWSDPQQWMGL-GQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITItGNNLKPNYKSFE
. ..|||||.. .|    . || |. ||||||.|. .  ||...||||| |  |||..|. |..|.||| || ..  | ||.. . |..|.|..  . 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvkl.gkdltprivqyq