Gene PpV in Drosophila melanogaster

Synonym: CG12217, DmPpV-6A, Dmel\CG12217, PP6, PPPV6A, PPV, PPV 6A, Ppv, dPP6, Dmel_CG12217, PpV

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP6C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP102_AA protein Get Run
DmelP102_AA_1-296 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049330 Metallo-dependent phosphatases 2-290 1.5e-107 352.2 In-house 15-303 (309) alignment 
Range on Protein: 2-290
Range on HMM: 15-303/309.0
GDVDKWIEDVKKCKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARY
...|..|| ..|.|.|.|.||..|......||..| |.|..| ...|.||||||..||..|..  | .| ....|.||.||||..|||....|| || .|
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

PSRITLLRGNHETRQITKVYGFFDECFSKYGnANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPE-DM
|....|||||||.|... .|||.||.. ||| |. |........ | .||.|....|||||||||.. .||||| ..|  |||. | .|||.||||  . 
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

EYWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEKRQTKIFLAVPDAE
| ....|||.|..|||.....|. .|.|.||.|.|..| .|....|||||.||.||||||.|.||..|.| ..   ... ..| .||   
egfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll
subfamily_PPP6C_pd Subfamily PPP6C 3-291 2.6e-178 584.3 In-house 1-289 (290) alignment 
Range on Protein: 3-291
Range on HMM: 1-289/290.0
DVDKWIEDVKKCKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYP
..||||| .|||||||||.|||||..|.|.||||.|. |||.||||||||||||||||.|||||||||.|.|.|.||||||||||||||||||||||.||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

SRITLLRGNHETRQITKVYGFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPEDMEY
.||||||||||.||||.||||.|||..|||||| ||||.||||||||||||||.||||||||||.. ||||||.|.|. |||.||||||||||||||.| 
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEKRQTKIFLAVPDAER
| .||||||.|||..|||.|..||||.|||||||||.||.||||| |||||||||||||||||||.||..|.||.|..|.| ||||.||
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdeer
subfamily_PPP4C_pd Subfamily PPP4C 3-287 8.6e-145 474.3 In-house 2-286 (288) alignment 
Range on Protein: 3-287
Range on HMM: 2-286/288.0
DVDKWIEDVKKCKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYP
|.|. ||....|. . |.|.|.||. . .||.||.|.  | .||||||||||||||| .||. ||.||.|||.|.|||||||.||.|||  ||.||.|||
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

SRITLLRGNHETRQITKVYGFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPEDMEY
 ||||.|||||.||||.||||.||| .|||.|| |.||..|||.|..|||||....||||||||.| |||.||.|||. |.| .|..|||.||||||.| 
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEKRQTKIFLAVP
|. ||||||.|||..|...|.. |...||||||||| || |..|. |..||||||||||||||||||| .. . ... ||| |..
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPP2C_pd Subfamily PPP2C 3-285 1.2e-131 431.2 In-house 3-285 (290) alignment 
Range on Protein: 3-285
Range on HMM: 3-285/290.0
DVDKWIEDVKKCKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYP
|.||.|| .|.|| | |.|.|.|||.. .|| .|.|. .|..|||||||.||||.|| .||. ||..|.|||.|.||.|||||||.|| | | .|| ||.
dldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvryk

SRITLLRGNHETRQITKVYGFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPEDMEY
.|||.||||||.||||.||||.|||. |||||| |||  ..|| |...|..||...|.||||||.| |||.||..||  |.| .|..|||.||||.| . 
eritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrgg

WGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEKRQTKIFLA
|| ||||||. ||......|   |.|.|| |||||| || ....| ..||..||||||||||| |||| .. . |..   | .
wgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
0045823 Metallo-dependent phosphatases 3-296 3.9e-113 371.5 In-house 29-334 (473) alignment 
Range on Protein: 3-296
Range on HMM: 29-334/473.0
DVDKWIEDVKKCKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYP
|.|..||  ||...|||..|.||......|| .| |.|..| ...|.||||||..||..|..  |  | ....|.||.||||..|||.. .|| || .||
dldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikyp

SRITLLRGNHETRQITKVYGFFDECFSKYgNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPEDMEY
....|||||||.|... .|||.||.. || ... ......... | .||.|.. .|.|||||||.. .|||||.|.|  |||  |...||.||||.....
gnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddg

--------WGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGK------LVTVWSAPNYCYRCGNVAAILSFETAEkRQTKIFLAVPD
        .| ||||||.|||......|.  |.|.||.|.|. | ||....||||      ..||.||||||.|.|| ||.| ..    .. ..| ..|.
dgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph

AERVIPKQ
  .    .
plilplfl
0053225 Metallo-dependent phosphatases 3-287 4.3e-104 340.9 In-house 8-292 (293) alignment 
Range on Protein: 3-287
Range on HMM: 8-292/293.0
DVDKWIEDVKKCKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYP
..|..|| ....|.|.|.||..|......||..| |.|..| ...|.|||||...||..|..  | .| ....|.||.||||..|||....|| ||..||
lldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllyp

SRITLLRGNHETRQITKVYGFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPEDMEY
....|||||||..... .|||.||.. |||.|. |........ | .||.|....|.|||||||....||||| |.|  .||. |...||.|||| . . 
dnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsg

WGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEKRQTKIFLAVP
|..|.||.|..|||.....|. .|.|.||.|.||.| .|....||||||||.|||||..|.||..|.| ...  ... |.| .|.
wlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP7C_pd Subfamily PPP7C 3-180 1.6e-33 108.9 In-house 19-202 (383) alignment 
Range on Protein: 3-180
Range on HMM: 19-202/383.0
DVDKWIEDVKKCKYLPENELKKLCEMVCDILLEETNILPVST----PVTVCGDIHGQFYDLEQLFRT-GGQVPHTNYIFMGDFVDRGYYSLETFTRLLTL
.|.| ||..|. | |  . . ..     ..| .  ||  |||     ||||||.||.. ||  ..   |   .. .|.| |||||||  |.|    ||.|
eveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillal

KARYPSRITLLRGNHETRQITKVYGFFDECFSKYG--NANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSpEIITLDQIRTIDRN
   ||  . | |||||   .   |||  |  |||   ...  .   .||  | .|..|||..| ||||.| ..  |. .  |.|.
llvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiers
subfamily_PPG1_pd Subfamily PPG1 5-288 1.1e-117 385.7 In-house 2-298 (300) alignment 
Range on Protein: 5-288
Range on HMM: 2-298/300.0
DKWIEDVKKCKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSR
|. .| ..|.. |||  .|.|.. . ..|..|.|.  . .|||| ||.||||||. ..|. ||||| |||.|.||.||||.||.|| . |..|| |||||
decleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsr

ITLLRGNHETRQITKVYGFFDECFSKY-GNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPE-----
|||||||||.||||.||||. ||. || ||.. |||  ..|| |..|||||||. ||||||||.. ..|||. .||  |.| .||..||.|||||     
itllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnp

-----DME--YWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEKRQTKIFLAVPD
     | |  .. .|.||||. .|..|.. |.  |..| | |||||.||| . .||.|| |||||||||||||| |.||  .  ..|  ... . |.
tldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
subfamily_PPP5C_pd Subfamily PPP5C 6-288 1e-77 254.3 In-house 23-311 (322) alignment 
Range on Protein: 6-288
Range on HMM: 23-311/322.0
KWIEDVKKCKYLPENELKKLCEMVCDILLEETNILPVST----PVTVCGDIHGQFYDLEQLFRTGGQVPHT-NYIFMGDFVDRGYYSLETFTRLLTLKAR
. .| .|| |.|..    |.  .. ..| ... .. ...     .|||||||||||||  .|.  |.. ..  |.| ||||||| .|.|.   ||..|  
ellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkll

YPSRITLLRGNHETRQITKVYGFFDECFSKYGNAnGWKYCCKVFDLLTIAAIIDEEVLCVHGGL-SPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPED
|| .. | |||||. .. |.||| .|. .|| ..   .   .||. | .| .|.|.|| ||||| | . .|||..|.|||| . | .|....|.||||..
yPnhfflsrGnhesdnmnklyGfegevkakytek.vadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe

MEYWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSF-ETAEKRQTKIFLAVPD
..  ..| || |  || .||| |.  |||.|| |.|.. .||.. . ||||.||.|||||| . || .|.... .. .| . | | ||. 
anGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeaveh
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 9-273 1.5e-84 276.5 In-house 16-281 (298) alignment 
Range on Protein: 9-273
Range on HMM: 16-281/298.0
EDVKKCKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLL
.. | .| . |....||.|.. .|. . . .. | .|..||||||||. || .||  .|  |..||.|.||.|||| ..||. . ||. |..||... ||
sekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffll

RGNHETRQITKVYGFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPED-MEYWGQSP
|||||. .| .||||..||  .| . . ..   .||. | ..|.| . .||.|||||... .|||.|.. |  . . .    ||.|.|||. .. | .. 
rGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaens

RGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFE
||..  ||..| ||..   ...|..||||.|..| ... . ||||..|||.|| .  | ||... .
rGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvd
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 11-293 1.3e-58 191.6 In-house 15-300 (307) alignment 
Range on Protein: 11-293
Range on HMM: 15-300/307.0
VKKCKYLPEnELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRG
|.| .|  | |....      |.  |  .. .  |. | ||.|||| || ..|   |. | | |.| ||.||||  |||.   |.| |  ||  | ||||
vhkiqytke.efenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrg

NHETRQITKVYGFFDECFSKYGN--ANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPEDME-YWGQSP
|||  .. | |||..|| .   .   . |    ..|. | |.|.|   .||.|||||| .  ||..|   .    |..|   |..|.||.     |  | 
nheiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkass

RGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEKRQTKIFLAVPDA-ERVI
||.|. || ||  |      ..|| ||||.. .|   .   ||.|..||| ||    |  ..|  . .   |.  |.   .  |..|
rgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpeseniekii
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 13-279 7.1e-68 222.0 In-house 19-286 (297) alignment 
Range on Protein: 13-279
Range on HMM: 19-286/297.0
KCKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNH
 .| . |. . || ..  |..  . ... | .|. ||||||||| || .||. ||  | .||.|.||.|||| .|.||   ||. | ..|. . ||||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ETRQITKVYGFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSP---EIITLDQIRTIDRNGEIpYKGAFCDLVWSDPE-DMEYWGQSPR
|   . |||||..||  .|     .     ||. | .. .| ...||.||||||   . .||| .| |.|. |   ..  .||.|.||   .  . .  |
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqr

GAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFEtaEKRQ
|||  ||..   .  .  .|.|.|||||.|..| ...   ||||..||| || .  |.||..| .  || |
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscd..eklq
subfamily_PPP1C_pd Subfamily PPP1C 14-277 8e-97 316.8 In-house 7-270 (282) alignment 
Range on Protein: 14-277
Range on HMM: 7-270/282.0
CKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHE
   | |.|...|...  .|||... .| .. ||...||||||..|| .|| |.|  |..||.|.||.||||  |||| . ||..| .||... |||||||
evklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhe

TRQITKVYGFFDECFSKYGNAnGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPE-DMEYWGQSPRGAGW
. .|...|||.|||  .|..   ||   .||. | .||..||..||||||||||.  |.|||.| |  |.| ||  |||.||||. ... |... ||  .
sasinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsf

LFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEK
 ||..| ..|.. |.|.||.||||.|..| ... . .||||.|||||| . .| .|.|| ..  .
tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeell
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 14-274 7.4e-69 225.3 In-house 3-263 (280) alignment 
Range on Protein: 14-274
Range on HMM: 3-263/280.0
CKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHE
|. .   |.  .  ||  |..||.|.    .|. | |||| |. |...||   |.||  . .|.||.||||   .| .  |. || ||  || |||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

TRQITKVYGFFDECFSKYGNANGWKYCcKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPED-MEYWGQSPRGAGW
|  . |.|||. ||  ||| .  | .   .|. . ....| . |||.|||||||.| || || | |  |   .| . ||.|||| .  | | .| ||  .
tpsvnkiygfyvecqykygvglwwdfq.scfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFET
.||. | ..     ...|| ||||.|..| . |   .|.||.| |||| .  | ||.. ...
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclna
subfamily_PPP3C_pd Subfamily PPP3C 15-275 1.3e-81 267.7 In-house 39-312 (452) alignment 
Range on Protein: 15-275
Range on HMM: 39-312/452.0
KYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHET
  | |..  |. |.....| .| ..| |..|.||.|||||||||| .||  ||.  .|.|.|.||.|||||.|.|.   |..||  |||.. |||||||.
grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhec

RQITKVYGFFDECFSKYGNaNGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPED--------MEYWGQS
| .|. . | .|| .||.. . .. |.. || | .||..... ||||||||||| .||.|...||  |.| .|..|||.|||| .         ..   |
rhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpns

PRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFD------GKLVTVWSAPNYCYRCGNVAAILSFETA
.||  ...... . .|.  |.|  | |||.  ..| .   .        |.|..|||||.    | ||.| .|. 
vrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 15-272 2.6e-74 243.2 In-house 22-280 (299) alignment 
Range on Protein: 15-272
Range on HMM: 22-280/299.0
KYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHET
| . |.||..||..  ....... .| | .|. ||||||||. || ..|   |  |..|..|.||.||||   ||. | ||  | .|| |. .|||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RQITKVYGFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPEDM-EYWGQSPRGAGWL
  | .||||..||  .|  .  |    . |. . .. .|   .||.||||||.. ||||.| . |  . |      ||.|.||...   |    ||  ..
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSF
||..| .| .   ...|..||||.|..| ... . ||||..||| || .  | |||.  
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkv
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 15-274 6.1e-74 242.0 In-house 6-271 (284) alignment 
Range on Protein: 15-274
Range on HMM: 6-271/284.0
KYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQV------PHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLL
| | |.|| .||    ... .|   | . .||...||||||| || .|.   |         ...|.|.||.|||| .|.|  | |...| ..| ...||
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHETRQITKVYGFFDECFSKYGNANgWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPE-DMEYWGQSP
|||||.| . . |||. ||  .| .|  ..     |  . ..|.... ..|.|||.| ... |.|.  ..|  .||  |  .||.|.||| ..|.. .||
rgnhesrpvnmqygfyleckkryseal.yeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFET
|||| .||..  |.|.   .|.|. ||||.| .| ... | ||||..||| || .  |.||.|. ..
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvde
subfamily_PPZ_pd Subfamily PPZ 15-272 4.5e-69 226.2 In-house 23-280 (300) alignment 
Range on Protein: 15-272
Range on HMM: 23-280/300.0
KYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHET
  | ..|. ..|    ...| . ..| .| .| . ||.|||. || .||   |  | .||.|.||.||||  ||||   ||  | .||  . ||||||| 
vclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhec

RQITKVYGFFDECFsKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPEDM-EYWGQSPRGAGWL
 ..|.||||.|||  .  | . ||     |. | .|||.  ...|||||||| . ..|.|| . |  ..|  |   ||.|||| |  . | .  ||  . 
anvtrvygfydeck.rrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsyc

FGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSF
. .   . |.    ..|.|||| .|..| ... |  ||||.||||||    |  |..| 
ynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 15-67 5.4e-10 31.9 In-house 7-59 (317) alignment 
Range on Protein: 15-67
Range on HMM: 7-59/317.0
KYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGG
. . |.|| .||    ... .|   | . .|||..||||||| ||  |.   |
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
PPP_3 17-283 2.2e-113 370.7 In-house 2-269 (271) alignment 
Range on Protein: 17-283
Range on HMM: 2-269/271.0
LPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQ
|.|||||.|.... .|| .|.|.. .|.|||||||||||..|| .||..||..|.|.|.|.||.||||..|||... ||.|| .||....|||||||.||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITKVYGFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDL-VWSDPEDMEYWGQSPRGAGWLFG
|.||||| .|...|.|... .|....||.||..||.|||.||.|||||||.| .||||....|. |.| .|...|| ..||||..| ...|.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

HNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEKRQTKIF
..||..|.  |.|.||.|||.|..|| ....|||.|||.||||||.|..|..|||..|.|.....|..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 17-284 1.9e-76 250.0 In-house 8-275 (281) alignment 
Range on Protein: 17-284
Range on HMM: 8-275/281.0
LPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQ
. ..|....  .|  |. || ..  . .|..| ||.|.|| ||..||   |.||.. ..|.||.||||  |||..  |.||| ||. || |||||||. .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

ITKVYGFFDECFSKYGNANgWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPED-MEYWGQSPRGAGWLFG
. |.|||. ||  |||    |    . |. | |.| |.. |||.|||||||...||..| . .  . ...|   ||.|.||..  | | .| ||....||
vnkiygfyvecvtkyGeel.walfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

HNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEKRQTKIFL
.|| .|     ...|| ||||.| .|.. .   ||.||.|.||||    | ||.|  . . . ... ..
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalv
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 17-273 3.6e-74 242.4 In-house 6-262 (280) alignment 
Range on Protein: 17-273
Range on HMM: 6-262/280.0
LPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQ
. | ..... | . .||. .. .. | .||.||||.|||. || .||   .  | .||.|.||.|||| . ||    ||. |.||| .. .||||||. .
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

ITKVYGFFDECFSKYGNANgWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPE-DMEYWGQSPRGAGWLFG
| . ||| ||.. .| .|  ..   ...| | ..|..   .||.|||||.....||... . |  . . .    ||.|.||| ..  |....||.  .||
inrkygfkdevkrryslal.ynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifg

HNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFE
.|| ||..   ...||.| ||.|..| ... | |||||.|||.|.    | ||.|  .
anvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivd
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 17-271 3.5e-59 193.6 In-house 3-259 (284) alignment 
Range on Protein: 17-271
Range on HMM: 3-259/284.0
LPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQ
.| .... |   ...|. ..  .. | .|. .|||||||| || .||   |   ..||.|.||.|||| . |||   |.. |  .| .. .||||||   
ippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

ITKVYGFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAF-CDLVWSDPEDME-YWGQSPRGAGWLF
| |.|||..||  .| .   ..    ||  . ..|.. . .||.|||.|  .  . |.|.| |  . |   ..  |..|||| ...  |    ||  ..|
inkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILS
| .  . ..   ...|. ||||.|..| ... . .|||..||| || .  | ||.. 
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmy
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 17-277 1.5e-52 171.7 In-house 6-291 (302) alignment 
Range on Protein: 17-277
Range on HMM: 6-291/302.0
LPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQ-----------VPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRI
. ..|| .|.|.| . | .| ..  .|.|||. ||||||| || ... .  .             .  ..|.||.||||. |.|  . ...||  ||.. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLLRGNHETRQITKVYGFFDECFSKYGNANG---WKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRN-GEIPYKGAFCDLVWSDPEDM-
 ||||||||. |   ||| .|   ..|...|   |.   .||  . .||.. | .||||||.|| . .|..|. |.|   |.       ||...|| |. 
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

---------EYWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEK
         .|     ||   .| .   .|.    ||.|| |||| . || |.. | ||.|..|||.|     |  |.|  .|  |
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 17-277 2.1e-52 171.2 In-house 7-292 (302) alignment 
Range on Protein: 17-277
Range on HMM: 7-292/302.0
LPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQ-----------VPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRI
. ..|| .|.|.| . | .| ..  .|.|||. ||||||| || ... .  .             .  ..|.||.||||. |.|  . ...||  ||.. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLLRGNHETRQITKVYGFFDECFSKYGNANG---WKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRN-GEIPYKGAFCDLVWSDPEDM-
 ||||||||. |   ||| .|  ...|...|   |.   .||  . .||.. | .||||||.|| . .|..|. |.|   |.       ||...|| |. 
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

---------EYWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEK
         .|     ||   .| .   .|.    ||.|| |||| . || |.. | ||.|..|||.|     |  |.|  .|  |
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 17-63 2e-06 20.1 In-house 11-57 (339) alignment 
Range on Protein: 17-63
Range on HMM: 11-57/339.0
LPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLF
.   || .||    ...  |  .| . .|. | ||||||| ||  ..
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllaml
PP2Ac_SM00156 18-282 1.2e-99 325.7 In-house 2-266 (271) alignment 
Range on Protein: 18-282
Range on HMM: 2-266/271.0
PENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQI
 ..|...|.| |..|| .| |.. ||.||||.||||||..|| .|....|..|...|.|.||.||||..|.|. . |..|| .||....|||||||....
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TKVYGFFDECFSKYgNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDP-EDMEYWGQSPRGAGWLFGH
.|.|||..|.  || ... .. . ..|.||..||..|...||.|||||||. .||.|| ..|. |.| .| ..||.|||| .. . . .| ||.. .||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

NVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEKRQTKI
...|.|.  |||.||.|||..|.|| ....|.||||..||||||....|.||.|..|...| . . 
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieq
PPP_1 19-271 1.1e-104 342.4 In-house 3-263 (264) alignment 
Range on Protein: 19-271
Range on HMM: 3-263/264.0
ENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQIT
|.||..|.... ..| .|.|.| ||...||||||||||.|| .||..||..|.|||.|.||.||||..|.|... ||.|| .||....|||||||.||.|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

KVYGFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDL--------VWSDPEDMEYWGQSPRGA
||||| .|.  |..... .|....|||.|..||.|||..|.||||||||. .|||||...|. |.| .|..|||        ...|.|. | . .|.|||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILS
|.|||..||..|.  |||.||.|||....|| ......|.||..||.||.....| .|...
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 20-273 1.5e-65 214.0 In-house 13-269 (287) alignment 
Range on Protein: 20-273
Range on HMM: 13-269/287.0
NELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITK
... .. | . .||     .| | .|.|..||||||. || ..|   |. |...|.|.||.||||  |||    |..|| .|| .. ||||||| ..| |
kdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkink

VYGFFDECFSKYGnANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEI-P-YKGAFCDLVWSDPEDM--EYWGQSPRGAGWLFG
.||| .|   |..  . .|   .||. |.. |.... .||.|||.||.. .||..... .        .|   ||.|.|||     .     |.   .||
lyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfG

HNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFE
...  |..   ...|| |||....|| ...|| .||||.||| |. .  |..|..  .
kkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvs
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 21-273 4.3e-58 189.6 In-house 20-276 (290) alignment 
Range on Protein: 21-273
Range on HMM: 20-276/290.0
ELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITKV
.. .. | . .||     .| | .|... ||||||. .| . |   |. |. ...|.||.||||  |||    |. .| ||. .. |||||||.|.. ..
dileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrl

YGFFDECFSKYgNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNG--EIPYKGAFCDLVWSDPED---MEYWGQSPRGAGWLFG
||| .|   |  ... ||   .||. |.. | ... .||.|||.|..| . . .... .        .|   ||.|.||.      .  .  |.   .||
ygfkeelarkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfg

HNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFE
...  |..    |.|| |||.. .|| ...|| |||||.||| |. .  |. ||.   
kkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvs
subfamily_PPPLV_pd Subfamily PPPLV 22-270 8.4e-55 179.1 In-house 2-274 (290) alignment 
Range on Protein: 22-270
Range on HMM: 2-274/290.0
LKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDL----EQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQI
|  ||..  |||..| ..|.. .|. | ||.||.. ||    ..|.||| ..  ....|.||.|||| .|.|  . ||.||  |||.. ||||||| . .
llslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesv

TKVYGFFDECFSKYGNA--NGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRN---GEIPYKGA--FCDLVWSDPED---ME------
.. . .  |.. |.|.   . |.   .||| | .||.||..|.|||.|.   | |  .| .|.      . . .||    |..||||..           
qesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelv

----YWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAIL
    .   . || | .|...  . |.  |||. . |||.  ..||..  .|.|.||.|. .||    . | ||
lneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalil
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 40-271 1.5e-49 162.0 In-house 3-241 (263) alignment 
Range on Protein: 40-271
Range on HMM: 3-241/263.0
LPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITKVYGFFDECFSKYGNANG---
| . .|. .||| |||. || ..| . |   .|.|.|.||.|||| .|||    |..||   | .. ||||||| . | | |||. |   ..   .    
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

-WKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPY-KGAFCDLVWSDPEDM--EYWGQSPRGAGWLFGHNVTKDFMAINNLNLIC
 ...  .||  . ..||. . .||.|||.|| . .||.||.|    |    .   |||.|.|||     .  .  |    .||..   |.    ...|| 
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidliv

RAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILS
||||.|. |  .. | .|.||.||  |     | ||.. 
rahqvveygyaffadrrlitvfsasryqielcnyaavvv
Metallophos Calcineurin-like phosphoesterase 45-237 1.3e-42 139.3 Pfam-A 2-198 (200) alignment 
Range on Protein: 45-237
Range on HMM: 2-198/200.0
PVTVCGDIHGQFYDL----EQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRL--LTLKARYPSRITLLRGNHETRQITKVYGFFDECFS---------
...|.||.||...||    ..|.. ... . ....|.||.|||| .|.||. .|  | || ..| .. ||||||| ......|||..|...         
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------KYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIrtidrngeipykgafcdlvwsdpedmeywgq
                        .... . . .....|..| ..|..|  .|..||.||..  . |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGWLFGHNVTKDFMAINNLNLICRAHQL
    ...||| ... ..   ... |..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 46-237 3e-78 255.1 In-house 1-197 (198) alignment 
Range on Protein: 46-237
Range on HMM: 1-197/198.0
VTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITKVYGFFDECFSKYGNANGWKYCCKVFD
||||||.|||..|| .||..|...|...|.|.||.||||..|||... ||.|| .||....|||||||.....||||| .|...|.|... .|....||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

LLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDL-----VWSDPEDMEYWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQL
||..||.|||.||.||||||.|| .||||....|. |.| .|...||     .....|..| . .| ||||.|||..||....  |.|.||.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 46-237 1.3e-74 243.5 In-house 1-196 (197) alignment 
Range on Protein: 46-237
Range on HMM: 1-196/197.0
VTVCGDIHGQFYDL-EQLFRTGGQVP-HTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITKVYGFFDECFSKyGNANGWKYCCKV
|||.||||||..||  .|...||. . ...|.|.||.||||..|||... || || .||....|||||||.......||| .|. .|  .....|....|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIP-YKGAFCDLV-WSDPE-DMEYWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQL
||||..||.|||.||.||||||.|. .||.|..|.|. |.|  .....||  ||||. ..| . .| ||||.|||..||..|.  |||.||.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 46-237 3.5e-73 238.8 In-house 1-198 (199) alignment 
Range on Protein: 46-237
Range on HMM: 1-198/199.0
VTVCGDIHGQFYDL-EQLFRTGGQVP-HTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITKVYGFFDECFSKYGNANGWKYCCKV
||||||.|||..||  .||..||. . ...|.|.||.||||..|||... || || .||....|||||||..|....||| .|. |||......|....|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIP-YKGAFCDLV-WSDPE-DMEY-WGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQL
|| |..||.|||.||.||||||||| ...... |.|. |||  ||  .||. ||||. ..|  . .| ||||.|||..||..|.  |||.||.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 46-118 6.5e-06 18.8 In-house 12-80 (235) alignment 
Range on Protein: 46-118
Range on HMM: 12-80/235.0
VTVCGDIHGQFYDLEQLFR--TGGQVPHTNYIFMGDFVDRGYYSLETFTRLltlkarYPSRITLLRGNHETRQIT
. | ||.|| . .| .|.   .||. .    ...||....|  |.|.   .        .    ..||||   . 
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 70-278 4.6e-65 212.9 In-house 99-307 (317) alignment 
Range on Protein: 70-278
Range on HMM: 99-307/317.0
PHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITKVYGFFDECFSKYGNAnGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEII
 . .|.|.||.|||| .|.|  . |..|| .|| ...|||||||.| . . |||. |.  .| .|  ..   ..|  | ..|......||.|||.| |..
gykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaa.lyeafqlafnvlplcavvnkkilcmhGGiseell

TLDQIRTIDRNGEIPYKGAFCDLVWSDPED-MEYWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAA
 |.|. ...|  .||  |  .||.|.||.  .... .|.|||| .||..  |.|.   .|.|. ||||.|..| ... | ||||..|||.|| .  |.||
dlkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaa

ILSFETAEKR
.|| ..  | 
vlsvdkklki
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 72-283 5e-50 163.5 In-house 120-331 (339) alignment 
Range on Protein: 72-283
Range on HMM: 120-331/339.0
TNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITKVYGFFDECFSKYgNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITL
  |.|.||.|||| .|.|    | .||  || || |||||||.| .   |||. |   .| .|. ..   ..|... ..|.|.. ..|.|||.|  . ..
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsf

DQIRTIDRNGEIPYKGAFCDLVWSDPEDMEY-WGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAIL
.|.  . |  |||  | . || |.||.  |  .  | ||| ..||    . |.   .|... | ||.|..| ...   .|||..|||||| .  | ||..
nqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavf

SFETAEKRQTKIF
| .   |   ..|
sidkklkisinvf
subfamily_PPP7C_pd Subfamily PPP7C 190-277 2.8e-16 52.2 In-house 238-326 (383) alignment 
Range on Protein: 190-277
Range on HMM: 238-326/383.0
CDLVWSDPEDME-YWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEK
 |..||||.  |  .  . ||.|  || .|||....  ||.|. |.|.   || ... | |..|..|| ||     |  | . . .. .
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdlt