Gene Pgam5 in Drosophila melanogaster

Synonym: CG14816, DPGAM5, Dmel\CG14816, EG:63B12.4, PGAM5, dPGAM5, Dmel_CG14816, Pgam5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PGAM5
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP108_AA protein Get Run
DmelP108_AA_85-278 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PFKFB_pd Subfamily PFKFB 85-156 2.1e-06 19.3 In-house 5-76 (198) alignment 
Range on Protein: 85-156
Range on HMM: 5-76/198.0
KARHIILVRHGEYLD--VGDSDDTHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIIlkQIDFE
| |.| ||||||  .   |.     .|||||...|.  .| . |  .|  .| .|...|...| ...  ..  |
kpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaell..glpke
0037864 Phosphoglycerate mutase-like 86-265 4.3e-34 110.1 In-house 7-206 (211) alignment 
Range on Protein: 86-265
Range on HMM: 7-206/211.0
ARHIILVRHGEYLD------VGDSDdtHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQIDFEKEKVVNCAFLRE-----------
 ....||||||  .       |..|   .|||.||.||. .|..| .||...| |..|...||..| .|||....... .|. .  |||           
mtrlyLvRHGetewnaegrlqgwld..vpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgalegltl

--GAPIPPQPPVGHWKPEASQFLRDG-------SRIEAGFRRYFHRAypdQEKESYTLIVGHGNVIRYFVCRALQFPAEGWLRININHASITWLTISPsG
   |   |. .| ..   .     .|        |... ......|.   ...... |.|.||.|.|......|... | .||.|....|.|.|.... |
eeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarl...lkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvleldd.g

NVSIKY
 . ...
gwvlvs
subfamily_PGAM5_pd Subfamily PGAM5 87-275 4.9e-102 330.9 In-house 2-188 (189) alignment 
Range on Protein: 87-275
Range on HMM: 2-188/189.0
RHIILVRHGEYLDVGDSDDtHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQIDFEKEKVVnCAFLREGAPIPPQPPVGHWKPEAS
||.||||||.| ...|||. ..|||.||.|||.|||||.||..|..|.||||||||.||.|||.||......|.. ...|||||||.|.|.|.||||||.
rhlilvrhgqyvldddsdk.kiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdvpkktk.tellreGaPikpePavkhwkpeal

QFLRDGSRIEAGFRRYFHRAYPDQEKESYTLIVGHGNVIRYFVCRALQFPAEGWLRININHASITWLTISPSGNVSIKYLGDSGFMPAE
||..||.||||.||.|||||.|.|...||.|||.|.|||||.||||||.|.|.|||...|..|||.|.|.|||.||...|||.||.|||
qfyedgarieaafrkyfhraspeqkedsyelivchanvirylvcralqlPpeawlrlslnngsitklsirPsGrvslrelGdvgflPae
0043909 Phosphoglycerate mutase-like 87-274 3.8e-38 123.7 In-house 3-242 (249) alignment 
Range on Protein: 87-274
Range on HMM: 3-242/249.0
RHIILVRHGEYLD------VGDSDdtHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQIDFEKEKVVNCAFLREG-----------
....||||||  .       |..|   .|||.||.||. .|..| ||||..|.|..|...||..|  |||......| .|. .  |||            
krlyLvRHGetewnaegrfqgwlD..spLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltka

-------------------APIPPQ-------------------PPVGHWKPEASQFLRDGSRIEAGFRRYFHRAYpdqEKESYTLIVGHGNVIRYFVCR
                    . |.                     |  .  |..  .     |..........|..    .... |||.||.|.|.....
eiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarll...kdggnvliVaHggvlrallay

ALQFPAEGWLRININHASITWLTISPSGN--VSIKYLGDSGFMPA
.|... | .||.|....|||.|.....|.  |....|.| ....|
llglsledilrlnlpngsitvlelddggkpvvvlvllndtshlea
0036777 Phosphoglycerate mutase-like 87-274 1.3e-37 122.1 In-house 3-237 (247) alignment 
Range on Protein: 87-274
Range on HMM: 3-237/247.0
RHIILVRHGEYLD----V--GDSDdtHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQIDFEKEKVVNCAFLREG-----------
....||||||  .    .  |..|   .|||.||.||. .|..| |||...|.|..|...||..| .|||....... .|| .  |||            
krlyLvRHGetewnaegrfqgwlD..vpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltka

---------------APIPPQPPVGHWK-------------------PEASQFLRDGSRIEAGFRRYFHRAYpdqEKESYTLIVGHGNVIRYFVCRALQF
                |... ||. ..                    |..  .     |... ......|..    .... |.|.||.|.|......|..
eiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarll...kdgenvlvVsHggvlrallayllgl

PAEGWLRININHASITWLTISPSGN-VSIKYLGDSGFMPA
. | .||.|....|||.|.. ..|. .....|.| .....
sledilrlnlpngsitvleldddgklwvleslndtshlel
0051064 Phosphoglycerate mutase-like 87-273 9.5e-37 119.6 In-house 4-237 (241) alignment 
Range on Protein: 87-273
Range on HMM: 4-237/241.0
RHIILVRHGEYLD------VGDSDdtHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQIDFEKEKVVNCAFLREG-------APIP
....||||||  .       |..|   .|||.||.||. .|.|| .||||.|.|..|.. ||..| .||........ .|| .  |||         ...
krlyLvRHGesewnaegrlqgwtD..vpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltle

------PQPPVGHWK--------------------------------PEASQFLRDGSRIEAGFRRYFHRAYpdqEKESYTLIVGHGNVIRYFVCRALQF
      |.  | ..                                 | .  .     |... ......|.     .... |.|.||.|||......|..
eiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarll...ldgknvlvVsHggvirallayllgl

PAEGWLRININHASITWLTISPSG-NVSIKYLGDSGFMP
| |..||.|....|.|.|.....|  |....|.| ....
pleellrlnlpngsvtvleldddgkrvvlvllndtshle
0049178 Phosphoglycerate mutase-like 87-272 2.4e-33 108.1 In-house 4-232 (243) alignment 
Range on Protein: 87-272
Range on HMM: 4-232/243.0
RHIILVRHGE------YLDVGDSDdtHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQIDFEKEKVVNCAFLREGA----------
....||||||       .  |..|   .|||.||.||. .|..| |||.|.| |..|.. ||..| .|||....... .|| .  |||            
trlyLvRHGetewnaegrlqgwtD..spLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltka

----------------PIPPQP----PVGHWK-------------PEASQFLRDGSRIEAGFRRYFHRAYpdqEKESYTLIVGHGNVIRYFVCRALQFPA
                |   .|    .....              |..  .     |... .........    ...  |.|.||.|||......|. | 
eiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaell...hdgktvlvVaHggvirallalllglpl

EGWLRININHASITWLTISPsGNVSIKYLGDSGFM
| .||.|....|.|.|.... | .....|.| ...
eellrlnlpngsvtvleldd.ggwvlvslndtshl
0036887 Phosphoglycerate mutase-like 87-271 4.1e-31 100.5 In-house 2-200 (202) alignment 
Range on Protein: 87-271
Range on HMM: 2-200/202.0
RHIILVRHGEYLD------VGDSDdtHHLTERGRKQAEFTGKRLCelGIKWDKVVASTMVRAQETSDIILKQIDfekEKVVNCAFLREG-----------
....||||||  .       ||.|   .|||.||.||. .|.||   |...| |..|...||..| .||.....    .|.    |||            
trlyLvRHGetewnvegrlqgdld..vpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealg...lpvivdprlrEidfgalegltle

--APIPPQPPVGHWKPEASQFLRD-------GSRIEAGFRRYFHRAypdqeKESYTLIVGHGNVIRYFVCRALQFPAEGWLRIN-INHASITWLTISPsG
  |   |.  . ..   .     .         |..| ......|.     ... .|.|.||.|.|......|... | .||.. ....|.|.|.... |
eiaekypeelaawlrdpydfrppggEsladvvaRvlaaleellarl.....dggnvlvVsHggvlrallayllglsledllrlrklpngsvtvleldd.g

NVSIKYLGDSGF
......|.| ..
gwvlvllndtsh
0053607 Phosphoglycerate mutase-like 87-261 9e-30 96.0 In-house 2-183 (191) alignment 
Range on Protein: 87-261
Range on HMM: 2-183/191.0
RHIILVRHGEYLD--VGDSDDTHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIIlkqidfeKEKVVNCAFLREG-------------AP
....||||||      |  .   .|||.||.||. ....| |||.|.|.|..|...||..| .||       . .|. .  |||              | 
trlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.......glpvevdprlrEidfgdwegltleelae

IPPQPPVGHWKPEASQ-------FLRDGSRIEAGFRRYFHraypdqekESYTLIVGHGNVIRYFVCRALQFPAEGWLRININHASITWLTISPSGNV
  |.  . ...            .     |... ......        .. .|.|.||.|||......|..| | .||.|....|.|.|.....| |
kypeelaawlrdpldyrppggEsladvaaRvlpaleella........ggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwv
0039931 Phosphoglycerate mutase-like 88-278 1.2e-33 108.8 In-house 1-197 (219) alignment 
Range on Protein: 88-278
Range on HMM: 1-197/219.0
HIILVRHGEYL----DVGDSddTHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIIlkqidfeKEKVVNCAFLREG-------------A
...||||||      .. ..    .||||||.||. .|.|| .||...| |..|...||..| .||       . .|. .  |||              |
rlyLvRHGetewnvegrlqg..dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltleeia

PIPPQPPVGHWKPE-------ASQFLRDGSRIEAGFRRYFHraypdqekESYTLIVGHGNVIRYFVCRALQFPAEGWLRININHASITWLTISPsGNVSI
   |.  . ...         .  .     |... ......        .. .|.|.||.|||......|... | .||.|....|.|.|.... |....
ekypeelaawlrdpydyrppggEsladvvaRvlpaleella........genvlvVsHggvirallayllglsleeilrlnlpngsvtvleldd.ggwvl

KYLGDSGFMPAELLT
..|.. .... .| .
vllnltshlddllrl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 88-228 3.7e-21 68.7 Pfam-A 1-158 (158) alignment 
Range on Protein: 88-228
Range on HMM: 1-158/158.0
HIILVRHGEYL------DVGDSDdtHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQID--FEKEKVVNCAFLR--EGAPI---PP
...||||||          |.||  ..|||.||.||. .||.|.. ....|.|..|.. ||..| .|.|...|  ..||. ..   .   || |    . 
rlylvRHGesewnkegrlqgwsd..vpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevke

QPP--VGHWKPEASQFLRD--------GSRIEAGFRRYFHraypDQEKESYTLIVGHGNVIRYF
. |  . .|| .  .|  .          |... ......    ...|.  .|||.||.|.| .
efpeeyekwkrdkkefrppegesladvyeRvapfleelie....akdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 88-228 3.7e-21 68.7 In-house 1-158 (158) alignment 
Range on Protein: 88-228
Range on HMM: 1-158/158.0
HIILVRHGEYL------DVGDSDdtHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQID--FEKEKVVNCAFLR--EGAPI---PP
...||||||          |.||  ..|||.||.||. .||.|.. ....|.|..|.. ||..| .|.|...|  ..||. ..   .   || |    . 
rlylvRHGesewnkegrlqgwsd..vpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevke

QPP--VGHWKPEASQFLRD--------GSRIEAGFRRYFHraypDQEKESYTLIVGHGNVIRYF
. |  . .|| .  .|  .          |... ......    ...|.  .|||.||.|.| .
efpeeyekwkrdkkefrppegesladvyeRvapfleelie....akdkgenvlivsHggvlral
0053031 Phosphoglycerate mutase-like 88-153 5.7e-06 19.0 In-house 6-91 (342) alignment 
Range on Protein: 88-153
Range on HMM: 6-91/342.0
HIILVRHGEY--LDVGD---------SDDTHHLTERGRKQAEFTGKRLCEL---------GIKWDKVVASTMVRAQETSDIILKQI
 |.|||||.   |. |.         ...  .||..||.||  .|.|| ..           .  .| .|.. |....   .|. .
vivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGl
0048955 Phosphoglycerate mutase-like 89-272 3.8e-34 111.0 In-house 3-228 (240) alignment 
Range on Protein: 89-272
Range on HMM: 3-228/240.0
IILVRHGEYLD------VGDSDdtHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQIDFEKEKVVNCAFLREG-------APIP--
..||||||  .       |..|   .|||.||.||. .|.|| .||||.|.|..|.. ||..| .||........ .|| .  |||         ...  
lyLvRHGesewnaegrlqgwtD..vpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldei

----PQPPVGHWK--------------------------------PEASQFLRDGSRIEAGFRRYFHRAYPdqeKESYTLIVGHGNVIRYFVCRALQFPA
    |.  | ..                                 |..  .     |..| ......||     .... |.|.||.|||......|..| 
aekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralk...pgknvlvVsHggvirallayllglpl

EGWLRININHASITWLTISPSgnvsIKYLGDSGFM
| .||.||...|.|.|.....    ...|.|  ..
eeilrlnipngsvtvlelddg....lvslndtshl
0035570 Phosphoglycerate mutase-like 89-276 1.2e-33 108.8 In-house 2-197 (219) alignment 
Range on Protein: 89-276
Range on HMM: 2-197/219.0
IILVRHGEYLDVGDSDD--THHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIIlkqidfeKEKVVNCAFLREG-------------APIP
..||||||  .  .       .||||||.||. .|..| .|||..|.|..|...||..| .||       . .|. .  |||              |   
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltldeiaeky

PQPPVGHWKPEASQFLRDG-------SRIEAGFRRYfhraypdqEKESYTLIVGHGNVIRYFVCRALQFPAEGWLRININHASITWLTISPSG-NVSIKY
|.  . ..   .     .|        |... ....        |...  |.|.||.|||......|..|.| .||.|....|.|.|.. ..| ......
peelaawlrdpydyrppggEsladvvaRvlpaleel........edgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvl

LGDSGFMPAEL
|.| ....  |
lndtshlelll
0050036 Phosphoglycerate mutase-like 89-257 3.2e-22 71.1 In-house 3-169 (171) alignment 
Range on Protein: 89-257
Range on HMM: 3-169/171.0
IILVRHGEYLD------VGDSDdtHHLTERGRKQAEFTGKRLcelgiKWDKVVASTMVRAQETSDIILkqidfekEKVVNCAFL----------------
..||||||          | .|    |||.||.||. .|..|     ..| |..|...||..| ..||        .|.    |                
lyLvRHGetewnlegrfqgwtd..vpLtelgraqaralgell.....pfdavysSpllRArqTaelil.......lpvivdprLrErdfGawegltldei

REGAPIPPQPPVGHWKPEASQFLRDGSRIEAGFRRYFhraypdqekeSYTLIVGHGNVIRYFVCRALQFPAEGWLRININHASITWLTISP
..  |   . .. .. |..  .     |. . ....           . .|.|.||.|||......|. ..| .||......|...|....
aakypewlldlldlappggEsladvlaRvlpaleell..........gnvlvvaHggvirallalllglsleeilrlelpngsvlvleldd
subfamily_TIGAR_pd Subfamily TIGAR 89-168 2.8e-12 38.8 In-house 3-85 (222) alignment 
Range on Protein: 89-168
Range on HMM: 3-85/222.0
IILVRHGE----YLDVGDSDDTHHLTERGRKQAEFTGKRLCElgIKWDKVVASTMVRAQETSDIILKQIDFEKEK-VVNCAFLRE
.|.|||||       .        |.|.|..||. ..||| .   | . ...|   ||..| .||||.. ..|.. |..   |||
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsn..ekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrE
subfamily_PGAM_pd Subfamily PGAM 89-162 4.4e-10 31.3 In-house 3-80 (248) alignment 
Range on Protein: 89-162
Range on HMM: 3-80/248.0
IILVRHGEYLDVGDS----DDTHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQIDFEKEKVVN
..|.||||     .         .|.|.|...|. .|| | . ... |.|..|.. |||.| ..||...| ||  |..
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvek
subfamily_STS_pd Subfamily STS 103-158 1.1e-09 30.0 In-house 51-103 (245) alignment 
Range on Protein: 103-158
Range on HMM: 51-103/245.0
SDDThhLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQIDfEKE
||.   |||||  ||. .|..|.| ||| . ...| ..|  .|.  |||... .| 
sDpP..lterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kki
subfamily_Cele-STS-like_pd Subfamily Cele-STS-like 109-154 5e-06 17.0 In-house 52-97 (229) alignment 
Range on Protein: 109-154
Range on HMM: 52-97/229.0
LTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQID
|||.|. ... .|. |.. ||.  .|  |  .|. .|. ..||.. 
lteiGkiaskligRaLrdrgiepsvvFCSPdlrsvqtaalllkglG