Synonym: CG10493, CT29458, Dmel\CG10493, PP2C, dPHLPP, Dmel_CG10493, Phlpp
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| LRR_8 | Leucine rich repeat | 109-169 | 4.8e-09 | 25.5 | Pfam-A | 1-61 (61) | alignment | ||
Range on Protein: 109-169
Range on HMM: 1-61/61.0
TNLQTLVADHNYLHNISTTNTHPVpLKLQRIDISHNNFSELP-NWVGACASLTAINASHNRL
.||..| ..| | .|.|. . .|. .|.|.|| .... .. . ||. .| |.|||
pnLkeLdLsnNrlkviptgsFkgl.snLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
|
|||||||||
| LRR_4 | Leucine Rich repeats (2 copies) | 135-175 | 2.7e-08 | 23.2 | Pfam-A | 2-42 (44) | alignment | ||
Range on Protein: 135-175
Range on HMM: 2-42/44.0
KLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVL
.|. .|.|.|| ..||.... . .|. .| |.|.. .. .|
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsaL
|
|||||||||
| LRR_4 | Leucine Rich repeats (2 copies) | 182-221 | 8.8e-06 | 15.2 | Pfam-A | 1-40 (44) | alignment | ||
Range on Protein: 182-221
Range on HMM: 1-40/44.0
TELVSLDLAYNDLKQLDQ-FpEGFSSIRSLQLQSNELPSLP
| | .|||..| .|.|. . .... ..| |..| . .|.
tnLevLdLsnNnIkdlppel.anLpnLktLnLsnNpisdls
|
|||||||||
| LRR_8 | Leucine rich repeat | 183-225 | 2.7e-06 | 16.7 | Pfam-A | 2-45 (61) | alignment | ||
Range on Protein: 183-225
Range on HMM: 2-45/61.0
ELVSLDLAYNDLKQLDQ-FPEGFSSIRSLQLQSNELPSLPDNFF
.| .||| |.|| ... . .| |. ..| |..|.| |.... |
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeaf
|
|||||||||
| LRR_8 | Leucine rich repeat | 206-266 | 3e-09 | 26.1 | Pfam-A | 2-61 (61) | alignment | ||
Range on Protein: 206-266
Range on HMM: 2-61/61.0
SIRSLQLQSNELPSLPDNFFAVThARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHL
....|.|..|.| ..|...| .|..|. |.|.|..... .. .| |.| ||.|
nLkeLdLsnNrlkviptgsFkgl.snLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
|
|||||||||
| LRR_4 | Leucine Rich repeats (2 copies) | 231-276 | 6.9e-06 | 15.5 | Pfam-A | 2-44 (44) | alignment | ||
Range on Protein: 231-276
Range on HMM: 2-44/44.0
RLETLNVSCNKLSTLPRyEQNNHAALVNLSLAGNHLNDsiFEPLHN
||.|. | |... || | | | .|.|..|.. | ...| |
nLevLdLsnNnIkdlpp.elanLpnLktLnLsnNpisd..lsaLan
|
|||||||||
| LRR_8 | Leucine rich repeat | 279-335 | 6.5e-11 | 31.5 | Pfam-A | 2-59 (61) | alignment | ||
Range on Protein: 279-335
Range on HMM: 2-59/61.0
KLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEV-ATLGQLRVLRCCNN
.|..|.| ||. |.| . ... |. | |||| |. ...|. . | .|| | .|
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgN
|
|||||||||
| LRR_4 | Leucine Rich repeats (2 copies) | 279-317 | 3e-07 | 19.9 | Pfam-A | 2-39 (44) | alignment | ||
Range on Protein: 279-317
Range on HMM: 2-39/44.0
KLRVLHLAYNRIGVLPAaCVRNWPELEILVLSGNMLQQL
.|.|| |..|.| ||. . |.| |. | ||.| .. |
nLevLdLsnNnIkdlpp.elanLpnLktLnLsnNpisdl
|
|||||||||
| LRR_4 | Leucine Rich repeats (2 copies) | 302-338 | 2.1e-07 | 20.4 | Pfam-A | 1-37 (44) | alignment | ||
Range on Protein: 302-338
Range on HMM: 1-37/44.0
PELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLL
. || | ||.| ...||.|.| | .|..| . || .
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpis
|
|||||||||
| LRR_8 | Leucine rich repeat | 327-381 | 1.2e-07 | 21.0 | Pfam-A | 3-59 (61) | alignment | ||
Range on Protein: 327-381
Range on HMM: 3-59/61.0
LRVLRCCNNLLLCTP--QLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGN
|..| .|| | | . .| |||||||.| | ... |. ..|..|.||||
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgN
|
|||||||||
| LRR_4 | Leucine Rich repeats (2 copies) | 349-381 | 3.1e-06 | 16.6 | Pfam-A | 3-34 (44) | alignment | ||
Range on Protein: 349-381
Range on HMM: 3-34/44.0
LKVLDLSHNHLDRVNL-LAlvPSRNLKYLDLSGN
|.|||||.| . .. || .|||.|.||.|
LevLdLsnNnIkdlppela..nLpnLktLnLsnN
|
|||||||||
| subfamily_PHLPP_pd | Subfamily PHLPP | 436-581 | 1.1e-40 | 132.0 | In-house | 5-138 (246) | alignment | ||
Range on Protein: 436-581
Range on HMM: 5-138/246.0
WTMGFAETpgSGDCRKLSVYQLraanyggSDEALYGMFEalegrGRAAQEMSHLVPDLMKQ---EQMVKDSAVRDYMKFTLLAAQQQCGS----VRSAAL
. .|..|. .| || | .| |.|||||.|. |....|.|.|...|||. |...||.....|||.|||.||...|. ..||||
fsiGlses..aGvknklcvaal.......svealyGlfd.....GdrneelssllqrlmkdvlkeevqkdkneeeymkntllvaqrklGeaGeklgsaal
FHLTRtraPSKVRPLKSkrYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQ
..|.| ..||.|.|| ..|..||.|.|.|.|||....|||.|..||.||.
lilir...hdkvdPaks..fsLevAsvGtlqavliRngkklrlsksyviekde
|
|||||||||
| 0034914 | PP2C-like | 464-657 | 1.6e-11 | 36.9 | In-house | 49-292 (295) | alignment | ||
Range on Protein: 464-657
Range on HMM: 49-292/295.0
GSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQ------EQMVKDSAVRDYMKFTLLAAQQQ-------------CGSVRSAALFHLTrtrapskvrplk
.| .|.|.| | | ...|| |... . . ...... ..|||... .|. ..||.. .
ledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallrpelagsGtTavvalirgn............
skryVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHS------------------------------------------MPDPHVLELILS-NDDEY
| .| .| |.|.|. ..||. . . |.| | |. .||..
....klyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddf
LVVGNAQLWSVMDIDRAAREIRK----EENSLLAAKRLVDIAQSFAAAESLSVIVVRFRH
|... || |.. . ... .|. . ||..|||.| . . . ..|.|||...
llLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng
|
|||||||||
| 0049733 | PP2C-like | 500-656 | 1.4e-07 | 24.5 | In-house | 59-234 (235) | alignment | ||
Range on Protein: 500-656
Range on HMM: 59-234/235.0
VKDSAVRDYMKFTLLAA-------------QQQCGSVRSAALFHlTRTrapskvrplkskryvLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIH---
...... ..||| . .|. ..||.. ... | .|. | |||.|. ..||... ...
lllldleealrkaflaaneallelalaspelagmgtTavvalld.ggk...............lyvanvGDsrayllrdgklvqltedhspvnelerqri
---------------------SMPDPHVLELILSNDDeYLVVGNAQLWSVMDIDRAAREIRKeENSLLAAKRLVDIAQSFAAAESLSVIVVRFR
.. .|.| .| |...| .|.. ||.|.. . ... .|. . ||.|||. | . . ..|.|||..
itaggavrvpgrlaltralGdlllkpdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvvvvrld
|
|||||||||
| PP2C | Protein phosphatase 2C | 581-645 | 2.2e-06 | 20.4 | Pfam-A | 184-252 (255) | alignment | ||
Range on Protein: 581-645
Range on HMM: 184-252/255.0
QIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENS----LLAAKRLVDIAQSFAAA
. . ..|.| . |...||.|.... || |.. . |. .|.|... ||..||| |.. ...
eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse
|
|||||||||
| PP2C | Protein phosphatase 2C | 581-645 | 2.2e-06 | 20.4 | In-house | 184-252 (255) | alignment | ||
Range on Protein: 581-645
Range on HMM: 184-252/255.0
QIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENS----LLAAKRLVDIAQSFAAA
. . ..|.| . |...||.|.... || |.. . |. .|.|... ||..||| |.. ...
eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse
|
|||||||||
| subfamily_PHLPP_pd | Subfamily PHLPP | 585-656 | 6.9e-31 | 100.0 | In-house | 175-246 (246) | alignment | ||
Range on Protein: 585-656
Range on HMM: 175-246/246.0
MPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFR
.|.||| |..|...||.|.|||..||.|..||.|....||||..|.|||.|||.|||..||.|.||.|||.|
lPkphvrevlLteqdellivGnkalWevlsideaveavrkeedplvaAkklvdlaqsygaadsvsvlvvrlr
|
|||||||||