Gene alph in Drosophila melanogaster

Synonym: CG1906, Dmel\CG1906, PP2Cb, SK3-1, pp2c99B, Dmel_CG1906, alph

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP127_AA protein Get Run
DmelP127_AA_3-286 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 4-286 5.8e-86 280.7 In-house 3-292 (295) alignment
Range on Protein: 4-286
Range on HMM: 3-292/295.0
FLDKPKTAKHNDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGDALPDWSFFAVFDGHAGCKVSEHCAKHLLESIIS-------TEEFIGGDHVKGIRT
.|..|.. ...   . ..| .||.|.||.|...|||...  .|   |.|...|.||||| |....|.....|.| ...       . ..   | .. .|.
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrk

GFLRIDEVMRELPEFtRESEKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAVSRALGDYDF
.||..|| ..|| .  | .  ..|||||.|..  ...|.||.|||||||.|.|..|. | ||||  ..|.|||..||| |.  ||||.|||.|||||.|.
aflaadeellelall.rpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl

KNVKEKGQCEQLVSPEPEIFCQSRQ-DSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSRDNMSIIIIAFPG
|...   ..|.|||.||........ ..|.||.||.||.|||.|||.......|... . .|  .|...|| .|..|||||...... ..|
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng

subfamily_PPM1G_pd Subfamily PPM1G 4-106 1.4e-24 79.9 In-house 1-100 (473) alignment
Range on Protein: 4-106
Range on HMM: 1-100/473.0
FLDKPKTAKHNDEGEGNKLLFGVSSMQGWRSEMEDAYYAragLGDALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVKGIRTGFLRIDE
.|.|||. |.....  ..| .|.|.||||| ..|||  .   . |   |.|.|||.||| | .|....||.|.. .  .. .  ||  |...  || .||
ylskpkvekesedesneelsygasamqGwrvsqEDahnc...itdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDe

VMR
 ..
klk

subfamily_PPM1G2_pd Subfamily PPM1G2 5-284 1.2e-81 266.8 In-house 2-286 (287) alignment
Range on Protein: 5-284
Range on HMM: 2-286/287.0
LDKPKTAKHNDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGD--ALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVKGIRTGFLRID
|..| .||... .. ..  .| |.|||.| .||||.  .  | .    .. ..||||||| | ||.....|.| . | . ..|  |   . .. .||..|
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletD

EVMRELPEFTResEKCgGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAVSRALGDYDFKNVKEK
| ...  ..    |.. |.||| . .  ...|.||.|||||||. .|     . ||||   .||.|| .||| | ..||||.||.||||||. ||. ..|
eellkdeklkd..esa.GstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkk

GQCEQLVSPEPEIFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSR------DNMSIIIIAF
.  ||.|  .|.. .......||||||||||||||..|..|. ....|..   .| .|.....|.|| . |.      |||...|...
kpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl

subfamily_PPM1A_pd Subfamily PPM1A 8-285 3.6e-119 390.3 In-house 3-281 (282) alignment
Range on Protein: 8-285
Range on HMM: 3-281/282.0
PktakhNDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGdALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFI--------GGDHVKGIRTGFL
|     ....|||.| .|||||||||.|||||. . | || ||.||||||||||||| .|.....|||||.|...||.           .. ...|.|||
p.....ksqaegnglrygvssmqgwrvemEDahtvvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfL

RIDEVMRELPEFTRESEKCgGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAVSRALGDYDFKNV
..|| .||| . .....|. |.|||...|  ....|||.|||||||||.|  .|.|.||||. |.||.|| .|||||...||||.||||||||||..|. 
aldeairelstdlktadks.GsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykee

KEKGQCEQLVSPEPEIFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSRDNMSIIIIAFP
.||...|||||.|||.....|...|.||||||||||||.|.|.|......|..|...| ..|...||..|.||||||.|.....|.
eekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa

PP2Cc_SM00332 14-282 1.5e-78 257.0 In-house 2-274 (274) alignment
Range on Protein: 14-282
Range on HMM: 2-274/274.0
NDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGdALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGG----DHVKGIRTGFLRIDEVMRELP
. .|....| .|.|||||||..||||.  .  |     ||.||.|||||.| .|.. ..|.| | .... ..  .    |  . ....||..|| ..|  
sesgsnlglsygkssmqgwrksmeDahvvvvdlv.eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileee

EFTRESEKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAVSRALGDYDFKNVKekGQCEQLV
.  .. .   |.|||.|..   ..|.||.|||||||||.|  |  ..||||  ..|..|| .|||.|. .||||.||||||.||...|. |  .. |. .
qskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyi

SPEPEIFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRM--RVTSNLVSIANQVVDTCLHK-GSRDNMSIIII
..||.. . .  ..||||.||.||.|||.||..|........  ..| .   .|..... .. . ||.||......
taepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 18-285 1.2e-50 165.2 In-house 2-254 (255) alignment
Range on Protein: 18-285
Range on HMM: 2-254/255.0
EGNKLLFGVSSMQGWRSEMEDAYYARAGLGDAlPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVKGIRTGFLRIDEVMRELPeftreseK
.....  | | | | |. ||| . .     |  .|  ..|.||||.| . .......|   . .  .    . || ..  .  |.  . | |       |
dssrfkvgfsdmiGrrptmedelviyGsfrdk.sdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserp.......k

CGGTTAVCAFVGLTQVYIANCGDSRAVLC-RQGVPVFATQDHKPILPEEKERIYNAGGSVMIK----RVNGTLAVSRALGDYdFknvkekgqCEQLVSPE
  ||||. ...   .||||| ||||.||| ..|. .  . ||||  ..|..|| ..|| |. .    ||||||||||||||  |         |  | |.
fiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.f........lePfvvpd

PEIF-CQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSrmrvTSNLVSIANQVVDTCLHKGSRDNMSIIIIAFP
|..      . .|.||.||||||||..|.|. .. . .     |.    |... |   ..|| ||.|.|.| ..
PdlsqsleiskkdkflilacdGiwdlisdeeaveivag....isdpekaaeklrdlayssGstdnisvivikls

PP2C Protein phosphatase 2C 24-277 1.2e-80 263.8 Pfam-A 3-255 (255) alignment
Range on Protein: 24-277
Range on HMM: 3-255/255.0
FGVSSMQGWRSEMEDAYYARAGLG--DALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGG-DHVKGIRTGFLR-IDEVMRElpEFTRESEKCG
.|.|..||.|..||||  | . |.  ..  ...||||||||.| .... ...|| |.. . ..| .. .  |..| .||. .||...   . .....   
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks..skantepsks

GTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPV-FATQDHKPILPEEKERIYNAGGSVM-IKRVNGTLAVSRALGDYDFKNVKekgqcEQLVSPEPEIFC
|.|||.|..  ...|.||.|||||||||.. .. . |.||||  ..|.||| .|||||. ..||||.|||||||||...|. .     |||||.||..  
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts

QSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSRDNM
 .....||||.||.||.|||.|.........|..  ....  .|...|| .. .||.||.
vklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 24-277 1.2e-80 263.8 In-house 3-255 (255) alignment
Range on Protein: 24-277
Range on HMM: 3-255/255.0
FGVSSMQGWRSEMEDAYYARAGLG--DALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGG-DHVKGIRTGFLR-IDEVMRElpEFTRESEKCG
.|.|..||.|..||||  | . |.  ..  ...||||||||.| .... ...|| |.. . ..| .. .  |..| .||. .||...   . .....   
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks..skantepsks

GTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPV-FATQDHKPILPEEKERIYNAGGSVM-IKRVNGTLAVSRALGDYDFKNVKekgqcEQLVSPEPEIFC
|.|||.|..  ...|.||.|||||||||.. .. . |.||||  ..|.||| .|||||. ..||||.|||||||||...|. .     |||||.||..  
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts

QSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSRDNM
 .....||||.||.||.|||.|.........|..  ....  .|...|| .. .||.||.
vklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PPM_PTC7 24-277 4.3e-79 258.6 In-house 3-259 (259) alignment
Range on Protein: 24-277
Range on HMM: 3-259/259.0
FGVSSMQGWRSEMEDAYYARAGLG--DALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGG-DHVKGIRTGFLR--IDEVMRElpEFTRESEKC
.|.|..||.|..||||  | |.|.  .   ...||||||||.| .... ...|| |.. . ..|  . .  |..|..||.  .||...   . ... .. 
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelks..seantepst

GGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPV-FATQDHKPILPEEKERIYNAGGSVM---IKRVNGTLAVSRALGDYDFKNVKEkgqCEQLVSPEPE
.|.|||.|..  ...|.||.|||||||||.| .| . |.|||| ...|.||| .|||||.     ||||.||||||.||...|. .     |||||.||.
sGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePd

IFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTsNLVSIANQVVDTCLHKGSRDNM
|    ....||||.||.||.|||.|.........|..  .  .  .|...||... .||.||.
isstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni

0049733 PP2C-like 24-284 7e-61 198.4 In-house 5-233 (235) alignment
Range on Protein: 24-284
Range on HMM: 5-233/235.0
FGVSSMQGW-RSEMEDAYYAraglgdalpDWSFFAVFDGHAGCKVSEHCAKHLLESIIST-EEFIGGDHVKGIRTGFLRIDEVMRELPEFTReSEKCGGT
.|..|..|. |...|||...         ....|||.||| |. ..|.....|.| ...  .|.   | .. .|  ||...|...|| .  . .   .||
vgaasdigrvrkvneDavlv.........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalasp.elagmgt

TAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVmikRVNGTLAVSRALGDYDFKnvkekgqceqlvspePEIFCQSRQ
|||.|..   ..|.||.|||||.|.|.|  |. |.||.|  ..|..||..||| |   ||.| ||..|||||...|               |....   .
TavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvlele

DSDeFLVLACDGIWDVMSNEDVCSFIHSrmrvtSNLVSIANQVVDTCLHKGSRDNMSIIIIAF
. | ||.||.||.|||.|.|.......|      .|  .|...|...|..|.|||...... .
pgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl

PPM_PTC7_SpoIIE 24-260 9.9e-41 133.0 In-house 3-213 (230) alignment
Range on Protein: 24-260
Range on HMM: 3-213/230.0
FGVSSMQGWRSEMEDAYYARAGLG--DALPDWSFFAVFDGHAGCKvsEHCAKHLLESIISTEeFIGGD-HVKGIRTGFLRIDEVMRELpeftresEKCGG
.|.|..||.|..||||  ..|...  .    . .....||| |      ....| . . .   | |..   . .| ..|...  ...        .. .|
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede.......psssg

TTAVCAFVGLTQ--VYIANCGDSRAVLCRQ-GVpvfatqdhkpilpeEKERIyNAGGSVM----IKRVNGTLAVSRALGDYDFKNvkekgqCEQLVSPEP
.|||.| .  ..  .|.||.|||...|.|. |               |.|||  ||| ..      ||.|.||||.| ||. ..        ...|..||
aTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaep

EiFCQSRQDS-DEFLVLACDGIWDVMSNEDVCSFIHSRMRVTsnlvsI
.   . . .. ||||.||.||.|||.|........ ...        .
d.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....a

subfamily_PPM1K_pd Subfamily PPM1K 25-284 1.2e-40 132.3 In-house 7-258 (263) alignment
Range on Protein: 25-284
Range on HMM: 7-258/263.0
GVSSMQGWRSEMEDayyaRAGLGDALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEeFIGGDHVKGIRTGFLRIDEVMRELPEFT--RESEKCGGTT
|. |..| |.| ||    |  | .  |.  ..||||||||    ... ..| . .         |  . ..  |. .|. ..   ||.   ....  |||
GkdsliGkraened....riklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaellssGtt

A-VCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMI-----KRVNGTLAVSRALGDYDFKNvkeKGqceQLVSPEPEIF
| |. .   |.. .|. |||||.|||.| .   |.||.| | |||||| .|||||        .||| ||..|.||| |.|.    |    .  ||   .
atvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkr...yG...viatPetksl

cQSRQDSDEFLVLACDGIWDVMSNEDVCSFIhsrmRVTSNLVSIANQVVDTCLHKGSRDNMSIIIIAF
 . . ..| ||||  ||| .|......| ..    |.  .    |. .... |  || || ..... .
.kvdhaadsflvlitdgisfvvnsqelcdlv....rlchdpeeaahalteqalqygsednatavvvpl

subfamily_PPM1E_pd Subfamily PPM1E 26-284 6.1e-56 182.5 In-house 8-262 (265) alignment
Range on Protein: 26-284
Range on HMM: 8-262/265.0
VSSMQGWRSEMEDAYYARAGLGDALP-----DWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGgDHVKGIRTGFLRIDEVMRElpEFTRESEKCgG
. .... |  ||| . |   |.  .      . .||||||||.| . ... |.|| | ... |...  | .. .. .| ..|| . .    .||. |. |
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklke.dpaealkeafkltDerflq..kaereklks.G

TTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMI---KRVNGTLAVSRALGDYDFKnvkekgqceQLVSPEPEIFC
.|||....   |.|.|  |||.|.|.|.|  |  .. |||  ..||.|| .||| |.     ||||.|.||||.||.. |         . || |...  
stavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsgeadvae

QSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTS-NLVSIANQVVDTCLHKGSRDNMSIIIIAF
 . ..|.|.|.|||||.|||. .|.|.. ... .. .. .| ..|...|..  ..||.||...... .
veldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl

subfamily_PPM1L_pd Subfamily PPM1L 26-284 6.7e-43 139.9 In-house 9-266 (269) alignment
Range on Protein: 26-284
Range on HMM: 9-266/269.0
VSSMQGWRSEMEDAYYARAGLGDALpDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDH--VKGIRTGFLRIDEVM---RELPEFTRESEKCGG
| |..| | .||| .    .. .   . ||||||||| |   .|.. . | ..| .    .  |.   . |  . |  ||..   ..| | .. .|.  |
vysvlGrrprmedrfeieediknkt.gesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaG

TTAVCAFVGLTQVYIANCGDSRAVLC-RQGVPVFATQDHKPILPEEKERIYNAGGSVMIK---RVNGTLAVSRALGDYDFKNvkekgqcEQLVSPEPEIF
|||. |.|  ... .|| |||| ||. ..|  .  . ||||  ..|. || .||| . ..   ||.| ||.||||||| .|.       ..|| ..|.|.
ttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkd.......knlviadpdil

CQSRQD-SDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSnlvSIANQVVDTCLHKGSRDNMSIIIIAF
.   .|   |||.||.||.|| .|||. . ||. |.         |  .|  . ..|| ||...... .
tfdlddhkpeflilasdGlwdtfsneeavrfikerlkepd...fGakslvlesfkrGsvdnitvlvvkl

subfamily_PPM1D_pd Subfamily PPM1D 26-179 2.8e-27 88.6 In-house 6-174 (309) alignment
Range on Protein: 26-179
Range on HMM: 6-174/309.0
VSSMQGWRSEMEDAYYARAGLGDAL--PDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDH---VKGIRTGFLRIDEVMREL----PEFTRESE
... || |  |||         . .   ...|.|||||| | . ...  .||.. |   ..|.  .    .. || .|| . | |..     |. ..   
seadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgll

KCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGV------PVFATQDHKPILPEEKERIYNAGGSVMIK
   |||| . ..  ...|.|. |||..||  .        .   |.||||  ||||||| ..||.|..|
staGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak

subfamily_ILKAP_pd Subfamily ILKAP 29-260 8.1e-41 133.1 In-house 12-252 (293) alignment
Range on Protein: 29-260
Range on HMM: 12-252/293.0
MQGWRSEMEDAYYARAGLG------D-ALPDWSFFAVFDGHAGCKVSEHCAKHLLESIIS---TEEFIGGD-HV-KGIRTGFLRIDEVMRELPEFTRESE
 .| | ||.||   .  |       .  .   |..|||||||| . ||..|..| ..|..    ...   . .. | .   | . || . .| . .. . 
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvW

KCGgTTAVCAFVGLTQVYIANCGDSRAVLCRQG------VPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAVSRALGDYDFKNVkekGqceqlVS
| | .||.. .|    .|.|| |||.|||.|.       . |  |.||.|.  ||..||  |||.|   ||.| | |||..||  ||..   |     |.
kdG.statvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrl...G.....vi

PEPEIFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSI
  |..     .. | |.||||||.|.|.|...| .|| . .    .  .|
stPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrki

subfamily_KAPP-like_pd Subfamily KAPP-like 31-283 6.3e-30 97.1 In-house 7-265 (266) alignment
Range on Protein: 31-283
Range on HMM: 7-265/266.0
GWRSEMEDAYYARAGLGDALP-----DWSFFAVFDGHAGCK--V--SEHCAKHLLESIISTEEFIGGDHVKGIRTGFLR-IDEVMRELPEFtrESEKCGG
|   |||| . |   |..        . ..|||||||||    .  ..   | | . . ||..  ||| .   .  ..  ..||  .| .|  | | .  
gcstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdf..eyeGata

TTAVCAFVGlTQVYI--ANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVM--IKRVNGtLAVSRALGDYDFKNVKEKGQCEQLVSPEPEIF
| |.    |  | |.  || ||| | |.|    .. ..|||   |||| || . | ..     |.|| |||||||||.  |.       |  ||..  . 
tlalvwsdG.qqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrillt

CQsrqdsDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHK-GSRDNMSIIIIA
 .     |.||..| ||.|||.| .|    ..| .   .   ..|. ...| ..   ..||.|.|.. 
pf.....dkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 31-283 7.3e-27 86.9 In-house 6-275 (276) alignment
Range on Protein: 31-283
Range on HMM: 6-275/276.0
GWRSEMEDAYYARAGLGDALP-----DWSFFAVFDGHAGCKVS----EHCAKHLLESIIS-----TEEFIGGDHVKGIRTGFLRI-DEVMRELPEFtrES
|   |||| . |   |.|        . ..|||||||||  ..    .   | |.  . |     |..  ||| .   .  .| . .||  .| .|  | 
gcstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdf..ey

EKCGGTTAVCAFVG-----LTQVY--IANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVM--IKRVNGtLAVSRALGDYDFKNVKEKGQCE
| .  | |.    |       | |  .|| ||| | |.|    .. ..|||   ||||.|| . | ..     |.|| |||||||||.  |.       |
eGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlise

QLVSPEPEIFCQsrqdsDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHK-GSRDNMSIIIIA
  ||..  .  .     |.||..| ||.|||.| .|    ..| .   .   ..|. ...| ..   ..||.|.|.. 
pyvsnrilltpf.....dkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk

subfamily_PP2D1_pd Subfamily PP2D1 31-78 1.8e-06 20.0 In-house 12-58 (492) alignment
Range on Protein: 31-78
Range on HMM: 12-58/492.0
GWRSEMEDAYYARAGLGDAlPDWSFFAVFDGHAGCKVSEHCAKHLLES
 |.|.|||..      |.  .. .||...||. |    | .||.| | 
rWKskmeDkrtlqdyfgnd.vnscFfgiyDGynGataAeiaakelhev

PP2C_2 Protein phosphatase 2C 50-247 6.6e-06 18.6 Pfam-A 21-191 (212) alignment
Range on Protein: 50-247
Range on HMM: 21-191/212.0
LPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVKG-IRTGFLRIDEVMREL------PEFTRESEKCGGTTAVCAFVGLTQVYIANCGDSR
  |....|| ||.  .| |.. |. . |..... | .  .  .  ... . .| . ....       | ..|. |  .|| ..|..  ........||..
asdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDga

AVLC-RQGVPVFATQDHKPILPEEKERIYNA--GGSVmikrvngtlavsralgdydfknvkekgqceqlvspepeIFCQSRQDSDEFLVLACDGIWDVMS
.|.  |.|    ......     |  ... .  ....                                       . . . .. . |.|  ||..| ..
ivvrdrdgevqllgepdsgeyanettfltsedaeeel......................................rirrlklepgdalllmTDGvsdslr

NED-VCSFI
.|. . ...
keepfrell

PP2C_2 Protein phosphatase 2C 50-247 6.6e-06 18.6 In-house 21-191 (212) alignment
Range on Protein: 50-247
Range on HMM: 21-191/212.0
LPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVKG-IRTGFLRIDEVMREL------PEFTRESEKCGGTTAVCAFVGLTQVYIANCGDSR
  |....|| ||.  .| |.. |. . |..... | .  .  .  ... . .| . ....       | ..|. |  .|| ..|..  ........||..
asdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDga

AVLC-RQGVPVFATQDHKPILPEEKERIYNA--GGSVmikrvngtlavsralgdydfknvkekgqceqlvspepeIFCQSRQDSDEFLVLACDGIWDVMS
.|.  |.|    ......     |  ... .  ....                                       . . . .. . |.|  ||..| ..
ivvrdrdgevqllgepdsgeyanettfltsedaeeel......................................rirrlklepgdalllmTDGvsdslr

NED-VCSFI
.|. . ...
keepfrell

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 55-194 1.1e-20 67.4 In-house 22-183 (292) alignment
Range on Protein: 55-194
Range on HMM: 22-183/292.0
F-FAVFDGHA--GCKVSEHCAKHLLESIISTEEFIGgDHVkgiRTGFLRIDEVMRELPEFTRESEKCGGTTAVCAFVGLT-QVYIANCGDSRAVLCR---
|  ||.|||   | ||..  ...|   ....      .      .  ||| ..  .| . | .  . ..|..||| |    ....|| |||||.| |   
flaavldGhGvnGdkvaqlaedtlevelleltrqlq.els...ealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclg

--QGVPVFATQDHKPILPEEKERIYNAGGSVMI-----------KRV------NGTLAVSRALGDY
  .  ..  ..||||  |.|..|| .||| |              ||      .| ||.||||||.
gsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdf

PP2C_SIG_SM00331 55-283 2.3e-14 46.5 In-house 32-216 (217) alignment
Range on Protein: 55-283
Range on HMM: 32-216/217.0
FFAVFDGH----AGCKVSEHCAKHLLESIISTeefiggdhvKGIRTGFLRIDEVMRELpeftrESEKCGGTTAVCAFV--GLTQVYIANCGDSRAVLCRQ
...|.||.    |.. .|.   . | |.. ..         . . . . |......|.     . || ...|...| .     ....||.|||| .| |.
llvvaDgmGkGlaAaaassqlrtalrellseg.........eelsqalkrlnraiyee.....keekgmfaTlllalydfssgklsyanaGdsrpyllrd

GVPVFATQDhkpilpeekeriynaggsvmikrvngtlavsralgdydfknvkekgQCEQLVSPEPEIF--CQSR-QDSDEFLVLACDGIWDVM-----SN
|  |. ..|                                              .  .... |||.    ...  . ...|.|. ||.....      .
gklveilkd..............................................vegaplGlepevsvdirelelekgdllllytDGltearsekgfae

EDVCSFIHSRMrvTSNLVSIAN----QVVDTCLHKGSRDNMSIIIIA
|... .. . .  .| .  .|.    ... .   .. .|....... 
erleeiledlv..dseaqelaqkiveellelakgsngeDdiTvvvvk

subfamily_PPM1H_pd Subfamily PPM1H 94-169 2.2e-10 32.9 In-house 140-210 (404) alignment
Range on Protein: 94-169
Range on HMM: 140-210/404.0
IRTGFLRIDEVMRElpEfTRESEKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPIlpEEKERI
. . ||..||....  |  .. .. || ||. | | | ..|.|| |||||.|.|..  .   .|. |    |..|.
lesaflemDeqiar..e.reayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPe..teRqRl

subfamily_TAB1_pd Subfamily TAB1 115-268 5.2e-14 44.8 In-house 125-299 (333) alignment
Range on Protein: 115-268
Range on HMM: 125-299/333.0
SEKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVP---VFATQDHKPILPEEKERIYNAGGS-VMIKRV--NGTLAVSRALGDYDFKNVKEKGQ----
.|  |||||| | .   ..|.||.|||||.|... .    .   .||.   ..| .|. . |     |||.   |     |..|||  |.  .  .    
eeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilss

-CEQLVSPEPEIFCQ-SRQDSDEFLVLACDGIWDVMS--------NED-VCSFIHSRMRVTSNLVSIANQVVDTC
  .. |  ||.|      .|.  ||||  ||.   .         | . .   .  ..    .| ..|..|||  
akgePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqavvdkv

subfamily_PDP_pd Subfamily PDP 116-271 7.5e-21 67.7 In-house 149-332 (398) alignment
Range on Protein: 116-271
Range on HMM: 149-332/398.0
EKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQ---G--VPVFATQDHKPILPEEKERIYNAG---GS---VMIKRVNGTLAVSRALGDYDFKNVKEKGQ
  . |..|..|..  |....|| ||.||||..|   |    |  ..|.    .|| ||| ..     |   .. .|. |.|. .|| ||. .|  .|  .
valsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqk

--CEQ----LVSP-----------EPEIFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHK
   |.     . |           |||.. .  . .| ||||| ||.||..|||.| | ..  .  . .  ... .  .. |..
kvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkq

subfamily_PPM1G_pd Subfamily PPM1G 119-284 4e-51 167.5 In-house 296-470 (473) alignment
Range on Protein: 119-284
Range on HMM: 296-470/473.0
GGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVM-IKRVNGTLAVSRALGDYDFKNVKEKGQCEQLVSPEPEIFC
 ||||| | .   ....|| ||||.||.|.|. .    ||||. ..|.||| .||| |    |||| | .||||||. .|. .| .. ||..|  |.|  
sGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikv

QSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTS--NLVSIANQVVDTCLHKGS------RDNMSIIIIAF
.  .. ||||||||||||.||. ..|  |...... ..   | .| ....|.|| .         |||..||. .
ltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll

subfamily_PP2D1_pd Subfamily PP2D1 130-254 7e-26 84.0 In-house 187-309 (492) alignment
Range on Protein: 130-254
Range on HMM: 187-309/492.0
LTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVM----IKRVNGTLAVSRALGDYDFKNVKekgqceQLVSPEPEIFCQSRQDSDE
|. .|||| |. .|||||.|. .  |..| |  ..|..|. .||..|.      .||| | . | || |   ..|      . | |||.. .   .. . 
lgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLk......ksvipePkttsvkldeaaq

FLVLACDGIWDVMSNEDVCSFIHSRMRVT
|||||  |.|.|.|.|.| | ... ... 
flvlAsnGlWevlseeevlsLvkqtlaiy

subfamily_PHLPP_pd Subfamily PHLPP 132-284 5.4e-12 38.1 In-house 106-245 (246) alignment
Range on Protein: 132-284
Range on HMM: 106-245/246.0
QVYIANCGDSRAVLCRQGVPVFATQDHKpILPEEKERIYNAGGSVMI-KRVNGTLAVSRALGDYDFKnvkekgqceQLVSPEPEIFCQSRQDSDEFLVLA
.. .|. |   |||.|.| ..  .. .. |  .| .|| .| . .    ..|| .. .| || .              | |.|..     .. ||.|.. 
sLevAsvGtlqavliRngkklrlsksyv.iekdelkrikeakaiitednkingviestrllGytflf.........PvvlPkphvrevlLteqdellivG

CDGIWDVMSNEDVCSFIHSrmrvTSNLVSIANQVVDTCLHKGSRDNMSIIIIAF
 . .|.|.| ... . ..       . . .| ..||     | .|..|.... .
nkalWevlsideaveavrk....eedplvaAkklvdlaqsygaadsvsvlvvrl

Subfamily Dicty-PPM1L-like 164-284 7.1e-13 41.0 In-house 181-303 (305) alignment
Range on Protein: 164-284
Range on HMM: 181-303/305.0
EEKERIYNAGGSVMIK---RVNGTLAVSRALGDYDFKNVKEkgqceqlvsPEPEI-FCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLV-
|.. ||  ......     .||. | .||  || . | .           |...       . .|.||||| ||.|.|.|..||  ...  .| .|    
eiririeslqaalynygellvnrllkksrskGdknlkelvi.........PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkk

------SIANQVVDTCLHKGSRDNMSIIIIAF
       | . .|   ...||.||. ..|| .
iewdfneisrviveeavkrgsgDnitlviikl

subfamily_PPM1H_pd Subfamily PPM1H 179-253 2.6e-14 45.8 In-house 275-353 (404) alignment
Range on Protein: 179-253
Range on HMM: 275-353/404.0
KRVNGTLAVSRALGDYDFKNVKEKGQCEQLVSPEPEIFC----QSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRV
.|. .|..|.| |||.. | |... .   ..||.||.      |  ...|. |.|| ||.|||.|||.|   ... .  
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlsk

subfamily_PPM1D_pd Subfamily PPM1D 185-284 8.4e-14 44.4 In-house 201-307 (309) alignment
Range on Protein: 185-284
Range on HMM: 201-307/309.0
LAVSRALGDYDFKNVKEKgqcEQLVSPEPEIFCQSRQDSDE-FLVLACDGIWDVMSNEDVCSFIHSRMRVTSN----LVSIANQVVDTCLHKGSR-----
|||.|.|||    | | .   | .|||||..  . .. ..| |..|| ||.|.|.. ||. |....   ...       |.|...|.. |.. ..     
LavaRslGDlWsynaksg...efvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklra

DNMSIIIIAF
||.|.|.. .
Dnvsvivvil

PPM_PTC7_SpoIIE_motif 225-283 2e-08 27.8 In-house 13-79 (81) alignment
Range on Protein: 225-283
Range on HMM: 13-79/81.0
EFLVLACDGIW-------DVMSNEDVCSFIHSRmRVTSnLVSIANQVVDTCLHKG---SRDNMSIIIIA
. |.|..||..       .....|......... .. | | ..| ..||..|  |   ..|....... 
dvllLyTDGltEardsdgelfgkeellrladra.egks.lqeladklvdevlengsgereDDitllvlr

PPM_PTC7_motif 228-277 8.2e-17 54.5 In-house 1-51 (51) alignment
Range on Protein: 228-277
Range on HMM: 1-51/51.0
VLACDGIWDVMSNEDVCSFIHSRMR-VTSNLVSIANQVVDTCLHKGSRDNM
.||.||.|||.|............      . ..|...||..| .|| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni

PP2C_C Protein serine/threonine phosphatase 2C, C-terminal domain 278-356 1.4e-30 94.9 Pfam-A 1-81 (81) alignment
Range on Protein: 278-356
Range on HMM: 1-81/81.0
SIIIIAFPGAPKPTEEAIEAEHRLEKQIEKITRDEIES---SKITDYVDLLKCLQNRDdIEGLPPGGGLQSKYHVIERTFKQ
|||...||||||..|||...|..|.|..|..... ||.   ....|....||.|.. | |..|||||||.||..|||...|.
siilvcfpgAPkvseeAvkkeaeLdkalesrveeiieksseeevpdllsvlktlased.ipnLPPGGglasKrsvieavykk