Gene Pp2C1 in Drosophila melanogaster

Synonym: CG2984, Dmel\CG2984, PP2C, PP2C1, anon-WO03040301.132, dpp2c1, Dmel_CG2984, Pp2C1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP129_AA protein Get Run
DmelP129_AA_250-568 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 251-568 1.1e-57 188.1 In-house 16-291 (295) alignment 
Range on Protein: 251-568
Range on HMM: 16-291/295.0
SLGVNMRVTGQCCQGGRKYMEDQFSVAYQESPITHelEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQ----KQFWSDQDEDVLRAIREGYIATHFAMWR
||  ..|| . . || ||..||...| ..  . ..  ....||..||||| .|| .|.|.|. .....     ..... .||...|.|....|.. ....
slllllrvgvasdqGrrksneDavlvvlnllslle..dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeelle

EQEKwprtaNGHLSTAGTTATVAFMRREKIYIGHVGDSGIVLGyqnkgeRNWRARPLTTDHKPESLAEKTRIQRSGGNVAIksgvPRVVwnrprdpmhrg
. ..     . .|.. ||||.||..|..|.|...|||| .||       ||.....||.|||| .  |. ||...|| |      .||            
lall.....rpelagsGtTavvalirgnklyvanvGDSravll......rngelvqltvdhkpvnelererilsaggavsh....grvn...........

pirrrtlvdeiPFLAVARSLGDLWSY---NSRFKEFVVSPDPDVKVVKINPSTFRCLIFGTDGLWNVVTAQEAVDSVRKEHLigeilNEQDVMNPSKALV
           ..||| |.||| . .   .  ..|..||. |||.|......   .|....||||.|.. .|.|| ||.        . .|... ...||
...........gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.....kgldleeaaeeLv

DQALKtwaakKMRADNTSVVTVILT
|.||.     ..  ||..|| | | 
dlAla.....rgsrDNiTvvvvrln
subfamily_PPM1A_pd Subfamily PPM1A 254-567 5.3e-46 150.2 In-house 10-280 (282) alignment 
Range on Protein: 254-567
Range on HMM: 10-280/282.0
VNMRVTGQCCQGGRKYMEDQFSVAYQESpitHELEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQKQFW-----SDQDEDVLRAIREGYIATHFAMwREQ
 ..|.. .  || |. |||...|. . .   .  . .|| ..|||.| |.| ..|.||. .|......      ......|. |.|.|..|.. |. ||.
nglrygvssmqgwrvemEDahtvvaslg...alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeai.rel

EKWPRTAnghlSTAGTTATVAFMRREKIYIGHVGDSGIVLGyqnkgeRNWRARPLTTDHKPESLAEKTRIQRSGGNVAiksgVPRVVWNrprdpmhrgpi
... .||      .|.||...... ....| ..||| .||       || .|  ||.||||..  ||.||.  ||.|     | ||  .           
stdlkta....dksGsTavtvlvsekhliianlGDsRavlc......rngkaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGa...........

rrrtlvdeipfLAVARSLGDLwSYNS----RFKEFVVSPDPDVKVVKINPSTFrCLIFGTDGLWNVVTAQEAVDSVRKEHLIGeilneQDVMNPSKALVD
           |||.|.|||  .|..    . .|  ||..|.|...... .    |.   ||.| |.. .|.|. |||.  ..     ..... .|||||
...........LAvsRalGDy.eykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrleva.....deleevakalvd

QALKtwaakKMRADNTSVVTVIL
.||.     |   || ||. |..
kale.....kgsrDNlsvlvvlf
subfamily_PPM1D_pd Subfamily PPM1D 255-568 6.8e-140 458.5 In-house 1-308 (309) alignment 
Range on Protein: 255-568
Range on HMM: 1-308/309.0
NMRVTGQCCQGGRKYMEDQFSVAYQESPITHELEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQKQFWSDQDEDVLRAIREGYIATHFAMWREQEKWPRT
...|| ...|||||||||.......|.....|||.||....||||| ||| ||.|||. .| |||.|.|...||||.||||...||| ||....|.||.|
slsvtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpkt

ANGHLSTAGTTATVAFMRREKIYIGHVGDSGIVLGYQNKGERNWRARPLTTDHKPESLAEKTRIQRSGGNVAIKSGVPRVVWNRPRDPmHRGPirrrTLV
..|.||||||||.| ..||||.|..|||||.||||.....|...||..||.||||||..||.||...||.||.|||| ||||.|||   |.||    | .
ksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprle.hngp....tvi

DEIPFLAVARSLGDLWSYNSRFKEFVVSPDPDVKVVKINPSTFRCLIFGTDGLWNVVTAQEAVDSVRKEHLIGEILNEQDvMNPSKALVDQALKTWAAKK
|||||||||||||||||||.. .||||||.|||||....|......|...||||||.|...||. |.||. ..|. .||. ....||||..||..|..||
deiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs.rsvakalvkealqrwrskk

MRADNTSVVTVILT
.||||.||..|||.
lraDnvsvivvile
PP2Cc_SM00332 255-565 3.3e-60 196.8 In-house 9-274 (274) alignment 
Range on Protein: 255-565
Range on HMM: 9-274/274.0
NMRVTGQCCQGGRKYMEDQFSVAYQESpitHELEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQKQFWSDQ-DEDVLRAIREGYIATHFAMWREQEKWPR
...   .. || || |||.. |  . .   .| . .|||..|||||.|.| |....|.  . .......|. ..|| .|..... .|. ... |.... .
glsygkssmqgwrksmeDahvvvvdlv...eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskel

TAnghlSTAGTTATVAFMRREKIYIGHVGDSGIVLGYQNKgernwrARPLTTDHKPESLAEKTRIQRSGGnvaiksgvprvvwnrprdpmhrgPIRRRtL
      ...|.||.||....|..|. .|||| .||. ..|      |..|..|||||   |. ||...||                        ....  
en....alsGstavvallkkedlyvanvGDSravlcrngk......avqlsvdhkpedederkRikkagg.......................vvekg.r

VDEIpfLAVARSLGDLWSY-NSRFKEFVVSPDPDVKVVKInPSTFRCLIFGTDGLWNVVTAQEAVDSVRKEHLIGeilNEQDVMNPSKALVDQALKTwaa
|.    ||| |..|| .   |. .|| .....||||||..  |  ..||. .||||.|.. ||.|| |||    |   ...|... .. |...|...   
vngg..lavsrafGdhflkknkklkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakg...ktndpqeaaelldeeairr...

kKMRADNTSVVTV
 .. .||..||.|
.ggseDniTvvvv
0049733 PP2C-like 255-567 6.6e-41 133.2 In-house 2-233 (235) alignment 
Range on Protein: 255-567
Range on HMM: 2-233/235.0
NMRVTGQCCQGG-RKYMEDQFSVayqespithelEYAFFGIYDGHGGPEAALFAKEHLMLEIVkqKQFWSDQDEDVLRAIREGYIATHFAMWREQEKWPr
...| . . .|  ||..|| . |           ....|...||||| .|. .| |.|.  ..  ... .   .|...|.|. . |.. |........| 
rlsvgaasdigrvrkvneDavlv...........glllfavaDGhgghaagevasellvetll..elllelllldleealrkaflaaneallelalasp.

tangHLSTAGTTATVAFMRREKIYIGHVGDSGIVLGyqnkgeRNWRARPLTTDHKPESLAEKTRIQRSGGNVaiksgvprvvwnrprdpmhrgpirrrtl
    .|.. ||||.||... .|.|. .|||| ..|       |. ....||.||.|    |. ||.. || |                            
....elagmgtTavvalldggklyvanvGDsrayll......rdgklvqltedhspvnelerqriitaggav............................

vDEIPFLAVARSLGDLWSYnsrfkefvvspdPDVKVVKINPSTfrCLIFGTDGLWNVVTAQEAVDSVRKehligeilneQDVMNPSKALVDQALKtwaak
   .. ||. |.||||.              ||| |....|    .|.. .||||.|.. .|.|| .|.          .|. .  ..||..||.     
.rvpgrlaltralGdlllk............pdvtvlelepgd..flllasDGlwdvlsdeeivdllrs..........ldleeaaerlvelala.....

KMRADNTSVVTVIL
.   ||..|| | |
rggrDNiTvvvvrl
subfamily_PPM1G2_pd Subfamily PPM1G2 255-427 3.4e-28 91.4 In-house 18-174 (287) alignment 
Range on Protein: 255-427
Range on HMM: 18-174/287.0
NMRVTGQCCQGGRKYMEDQFSVAYQESPITHELEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQKQFWsdqDEDVLRAIREGYIATHFAMWREqekwpR-
...|.  . || |  |||   .  .    . . . |.|...||||| ..| .| ..|.  |.|.|.|    .. . .........|   . ..     . 
ltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk...egaleqilkdafletDeellkd.....ek

TANghlSTAGTTATVAFMRREKIYIGHVGDSGIVLGYQNKgernwrARPLTTDHKPESLAEKTRIQRSGGNVAI
...   ..||.||.|. .. ||.|.. .|||  ||  . .      .. |. ||||.. .||.||. .|| |..
lkd...esaGstavvvlikeeklyvanaGDsravlsskgn......vkalsfDhkPqeesekkriiaagGfvel
subfamily_PPM1E_pd Subfamily PPM1E 256-434 4.2e-26 84.7 In-house 4-167 (265) alignment 
Range on Protein: 256-434
Range on HMM: 4-167/265.0
MRVTGQCCQGGRKYMEDQFSVAYQ---ESPITHELEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQKQFWSDQDedvlRAIREGYIATHFAMWReqekwp
..|. .. .. |. |||.. .  .      .. | |.|||...||||| ||| .|..||   .|.|... .|      .|..|.. .|  .. .      
yevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa....ealkeafkltDerflq......

rTANGHLSTAGTTATVAFMRREKIYIGHVGDSGIVLGyqnkgeRNWRARPLTTDHKPESLAEKTRIQRSGGNVAIKsGVPRV
 .|.    ..|.|| |........|.. .|||  .|       |. .|. |.. ||||   || ||.  || |    |. ||
.kaereklksGstavvvliekdqlyvaWlGDsqallv......rkgeavqlmkpHkPeredEkkRieeagGlvvvi.gawRv
PP2C Protein phosphatase 2C 257-557 2.3e-58 190.7 Pfam-A 2-252 (255) alignment 
Range on Protein: 257-557
Range on HMM: 2-252/255.0
RVTGQCCQGGRKYMEDQFSVAYQESPITHELEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQKQFWSDQdeDVLRAIREGYIAtHFAMWREQekwPRTAN
.|.. ..|| || |||.     . .   .. . |||...||||| ||| .|.|||   . .||.| ...  .| .|.|... | ..... ..   .....
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant

gHLSTAGTTATVAFMRREKIYIGHVGDSGIVLGYQNKGErnwraRPLTTDHKPESLAEKTRIQRSGGNVAIksgVPRVVWNrprdpmhrgpirrrtlvde
 . |. |.||.||..| .|.|. .|||| .||. ... .       ||.||||..  |. ||...|| |     . ||...                   
.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.....keltedHkpsdedEreRIeeaggsvsn...ngrvngs...................

ipfLAVARSLGDLWSYNSRfkEFVVSPDPDVKVVKINPStFRCLIFGTDGLWNVVTAQEAVDSVRKEHLIGEilneqdvmnpSKALVDQALKTWAAKKMR
   |||.|.|||.....    |..||..|||..||....   .|| ..||||.|.. ||||| ||.|   ..          |.  . ..| ..| .. .
...LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk..........spmeaaeelvdeaiargs

A
.
e
PP2C Protein phosphatase 2C 257-557 2.3e-58 190.7 In-house 2-252 (255) alignment 
Range on Protein: 257-557
Range on HMM: 2-252/255.0
RVTGQCCQGGRKYMEDQFSVAYQESPITHELEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQKQFWSDQdeDVLRAIREGYIAtHFAMWREQekwPRTAN
.|.. ..|| || |||.     . .   .. . |||...||||| ||| .|.|||   . .||.| ...  .| .|.|... | ..... ..   .....
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant

gHLSTAGTTATVAFMRREKIYIGHVGDSGIVLGYQNKGErnwraRPLTTDHKPESLAEKTRIQRSGGNVAIksgVPRVVWNrprdpmhrgpirrrtlvde
 . |. |.||.||..| .|.|. .|||| .||. ... .       ||.||||..  |. ||...|| |     . ||...                   
.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.....keltedHkpsdedEreRIeeaggsvsn...ngrvngs...................

ipfLAVARSLGDLWSYNSRfkEFVVSPDPDVKVVKINPStFRCLIFGTDGLWNVVTAQEAVDSVRKEHLIGEilneqdvmnpSKALVDQALKTWAAKKMR
   |||.|.|||.....    |..||..|||..||....   .|| ..||||.|.. ||||| ||.|   ..          |.  . ..| ..| .. .
...LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk..........spmeaaeelvdeaiargs

A
.
e
PPM_PTC7 257-548 6.2e-58 189.3 In-house 2-252 (259) alignment 
Range on Protein: 257-548
Range on HMM: 2-252/259.0
RVTGQCCQGGRKYMEDQFSVAYQESPITHELEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQKQFWSDQdeDVLRAIREGYIATHFAMWREQekwPRTAN
.. . ..|| || |||   .. . .   .. . |||...||||| ||| .|.|||   . ..|.| ...  .. .|.|... | ..... ..   .....
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelks...seant

gHLSTAGTTATVAFMRREKIYIGHVGDSGIVLGYQNKGErnwraRPLTTDHKPESLAEKTRIQRSGGNVAIKsGVPRVVWNrprdpmhrgpirrrtlvde
 . || |.||.||. . .|.|. .||||..||. ...        .||.||||..  |. ||...||.|  . |. ||...                   
.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav.....kqltedHkpsnedEreRiegaggsvsnv.gngrvngv...................

ipfLAVARSLGDLWSYNSRFKEFVVSPDPDVKVVKINPStFRCLIFGTDGLWNVVTAQEAVDSVRKEHLIGeilneqDVMNPSKALVDQALK
   |||.|..||.....   .|..||..||....||...   .|| ..||||.||. ||||| ||.|   .      | |. ...||| |..
...lavsRafGdfelkpketeeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk......dpmeaaeklvdeaia
subfamily_PPM1G_pd Subfamily PPM1G 257-341 2.7e-10 32.8 In-house 20-96 (473) alignment 
Range on Protein: 257-341
Range on HMM: 20-96/473.0
RVTGQCCQGGRKYMEDQFSVAYQespitHELEYAFFGIYDGHGGPEAALFAKEHLmLEIVKQKQFWsdQDEDVLRAIREGYIATH
...    || |. .||   .  .      . . ..|..|||||| | | .  ..| ....|.....  ...|| .|..| ..|  
sygasamqGwrvsqEDahncitd.....ldedtslfavyDGHGGkevakyvakkl.pdllkaqkgy..kegdvekaleeaflalD
PPM_PTC7_SpoIIE 258-523 1.1e-24 80.6 In-house 3-208 (230) alignment 
Range on Protein: 258-523
Range on HMM: 3-208/230.0
VTGQCCQGGRKYMEDQFSVAYQESPITHELEYAFFGIYDGHGGPEaalfAKEHLMLEIVKQKQ-FWSDQdeDVLRAIREGYIATHFAMWREqekwprtan
. . ..|| || |||   .. .     ..   ...|..|||||..    |. . .|  . ... | . .  ..  ..|... | . ... |         
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra....alamgllrtalrelafagle..kpeeilrrlnlalaadlede.........

ghLSTAGTTATVAFMRREK--IYIGHVGDSGIVLGYQNKGernwrarplttdhkpeslaEKTRIqRSGGNVA--IKSGvpRVVWNrprdpmhrgpirrrt
   |. |.||.||  . ..  .|. ..||| ..|  ...|                   |..||  .|| .   | .|  ||...               
..psssgaTavvalidpstgklyvanaGdsppllvrddgg...................ereri.vagglpslGilpg..rvfgv...............

lvdeipfLAVARSLGDLWSYNsrfKEFVVSPDPDvKVVKINPSTFRCLIFGTDGLWNVVTAQEAVDSVRKE
       |||... |||. .    ...||.. ||  . .. ..  . || ..||||.|...||.|| ||.|
.......lavslapGdlllly...tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrde
subfamily_PPM1L_pd Subfamily PPM1L 258-434 1.7e-23 76.2 In-house 7-172 (269) alignment 
Range on Protein: 258-434
Range on HMM: 7-172/269.0
VTGQCCQGGRKYMEDQFSVAYQespITHELEYAFFGIYDGHGGPEAALFAKEHLMLEIvKQKQFWSDQDEDVLRAIREGYIATHFAMWREqEKWPRTANG
|.  . .| |. |||.| .. .   |... .  ||...|||||  || |||. |. .| |.|    |.| .    |  . . |.  .  . ||   .|. 
vavysvlGrrprmedrfeieed...iknktgesffavfdGhGGefaaefakdvlvkai.knklieldadkentepinfsklltdeilsvd.ekllekakr

HLSTAGTTATVAFMRREKIYIGHVGDSGIVLgYQNKGernwRARPLTTDHKPESLAEKTRIQRSGGNVAIKsGVPRV
   .||||| .|... ... .  ||||  || |...|    .| ||. ||||. . |. ||...|| .|.. || ||
aediaGttalialvqesdlivanvGdsrGvl.ydkrG....kaiplsfdhkpqqvkerkrikkaGGfiafr.Gvwrv
subfamily_PPM1K_pd Subfamily PPM1K 262-429 1.4e-19 63.2 In-house 10-160 (263) alignment 
Range on Protein: 262-429
Range on HMM: 10-160/263.0
CCQGGRKYMEDQFSVAYqespITHELEYafFGIYDGHGGPEAALFAKEHLMLEIvkqkQFWSDQDEDVLRAIREGYIATHFAMWREQEKWprTANGHLST
  .| |.  ||.....     .. || |  ....|||.|. || |. ..|   .    ... ....|.   ... .   . .. |  |     |. .| .
sliGkraenedriklke....ldpelly..vavfdGhaGsaaadfvhdklekil....krllekekdleivlknafeeldkklkrylefs..vaeaells

AGTTATVAFMRR-EKIYIGHVGDSGIVLGyqnkgeRNWRARPLTTDHKPESLAEKTRIQRSGGNVAIKS
.||||||...|   .. .  .|||  .|       || .|. ||.||.||   || ||...||.|. .|
sGttatvsllrdGtelvlaslGdsrailc......rnGkakkltrdhdPeleeekerikaagGsvewns
subfamily_ILKAP_pd Subfamily ILKAP 262-426 1.6e-19 63.2 In-house 11-177 (293) alignment 
Range on Protein: 262-426
Range on HMM: 11-177/293.0
CCQGGRKYMEDQFSVAYQES--PITH---ELEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQK--QFWSDQDedvlRAIREGYIATHFAMWREQEKWPRT
. .| |. |.|.  .  . .  . ..       ......|||.|. |. ||.|.|  .|...   .  | ..    . |.  .. .. .  .|  |  . 
erkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsake....keikkclvdsfkktdeefLklask

ANGhLSTAGTTATVAFMRREKIYIGHVGDSGIVLGYQNKGERNWRARPLTTDHKPESLAEKTRIQRSGGNVA
|.      |.|||| ..  . .|.. .|||  ||  ...  ..  . .|| ||.| .. |. |||..||.| 
akP.vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr
Subfamily Dicty-PPM1L-like 262-317 2.9e-06 19.3 In-house 13-64 (305) alignment 
Range on Protein: 262-317
Range on HMM: 13-64/305.0
CCQGGRKYMEDQFSVAYQespITHELEYAFFGIYDGHGGPEAALFAKEHLmLEIVK
  .. ||| ||.  |      .  . |  .||..|||.|  || ..| .| .||| 
vsansrkyqedrnkvkis...lessqelslfGvfdGhnGdiaaeyvkkkl.veivn
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 264-522 1.1e-28 93.2 In-house 14-222 (255) alignment 
Range on Protein: 264-522
Range on HMM: 14-222/255.0
QGGRKYMEDQFsVAYQESPITHELEYafFGIYDGHGGPEAALFAKEHLMlEIVKQKQfwSDQDEDVLRAIREGYIATHFAMwreqEKWPrtanghlSTAG
 | |  |||.. |.| .    .. .|  . ..||||| .|| || |.|   |....     .. . ...... | ...  .    ...|          |
iGrrptmedel.viyGsfrdksdedy..yalfdGhgGraaakfaseely.kilaell..dlnnanPvkslkkaykeistqi....serp.......kfiG

TTATVAFMRREKIYIGHVGDSGIVLGyqnkgERNWRARPLTTDHKPESLAEKTRIQRSGGNVAIKsgvprvvwnrprdpmhrgpiRRRTLVDEipFLAVA
|||..... ..|.||  |||| .||.     ...  |. |. ||||    |. ||.. ||.|  .                    .  . |.    |||.
ttaasvliiedkvyianvGdsrvvlc.....qkdgtakrlsldhkPseeseekriselGGtvvst....................vvtsrvnG..tlavs

RSLGDLWsynsrFKEFVVsPDPDVKVVKINPSTFRCLIFGTDGLWNVVTAQEAVDSVRK
|.||| .     .. ||| ||||..    .  . . ||   ||.|.... .|||. | .
ralGdsf.....lePfvv.pdPdlsqsleiskkdkflilacdGiwdlisdeeaveivag
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 268-469 4.6e-19 62.0 In-house 5-183 (292) alignment 
Range on Protein: 268-469
Range on HMM: 5-183/292.0
KYMEDQFSVAYQESPITheleyaF-FGIYDGHG--GPEAALFAKEHLMLEIVKQKQFWSDQDEdvlrAIREGYIaTHFAMWREQekwprtANGHLSTAGT
|  .|.| .    ...|      |   ..||||  | . | .|...|  |...  .   .  |    |.  . .    | ...          .   |.|
kenqdrfllvegsealt......flaavldGhGvnGdkvaqlaedtlevelleltrqlqelse....alllril.diaakldkl......tidaresatt

TATVAFMRRE-KIYIGHVGDSGIVLGYQNKGeRNWRARPLTTDHKPESLAEKTRIQRSGGNVAiksgvPrvvwNRPRDPMHRGPIRRRTLVDEIPFLAVA
... | .| . .... .||||  .||    |  . . .||. |||||   |. ||.|.|| |      |     | |   .||. |     ..   ||..
avvcarvrddralilanvGdsrallgrclgg.sdyeliPlsrdhkPedPderarilraGGrve.....p....trvrgwgfrGtarvwrrrqqeGdlals

RSLGDL
|.|||.
ralGdf
subfamily_KAPP-like_pd Subfamily KAPP-like 283-425 3.9e-06 19.1 In-house 28-161 (266) alignment 
Range on Protein: 283-425
Range on HMM: 28-161/266.0
ITHELEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQKQFwsDQDEDVLRAIREG--YIATHFAMWREQEKwprtangHLSTAGTTATVAFMRRE----KI
..   . |.|...||| |  ||  ||. .  |. |. .    ...|    | .    .   |    .. |       .    |.|||.|.. ..     .
lsncsnialfavfdGhaGkGaadaakklfpkelekllks..tkqddGGdniydqskllenafkevdaklk.......dfeyeGatatlalvwsdGqqryl

YIGHVGDSGIVLGYQNKgernwrARPLTTDHKPESLAEKTRIQRSGGNV
 .. ||||   | . |.      .  |. ||| .   || ||.  |  .
qvanvGdssaflsrGne......slelskdhkakdpeekqrikddGitl
PP2C_SIG_SM00331 288-565 8.3e-09 28.3 In-house 29-215 (217) alignment 
Range on Protein: 288-565
Range on HMM: 29-215/217.0
EYAFFGIYDGHG-GPEAALFAKE--HLMLEIVKQKQFWSDQDEDVLRAIREGyiathfamwreqekwprtanGHLSTAGTTATVAF--MRREKIYIGHVG
.. .. . ||.| | .||.....  ... |......  |.  . . |||.|                      . .  ..|...|   ... |... ..|
grlllvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee....................keekgmfaTlllalydfssgklsyanaG

DSGIVLGYqNKGERNWRARplttdhkpeslaektriqrsggnvaiksgvprvvwnrprdpmhrgpirrrtlvdeipflavarslgdlwsynsrF------
|| ..|   ....  .                                                                                    
dsrpyllr.dgklveilkd..........................................................................vegaplG

-----KefvvspdpdVKVVKINPSTFRCLIFGTDGLWNVVTAQEavdsVRKEHLIGEILNEQdvmNPSKALVDQ----ALKTWAAKKMRADNTSVVTV
     .         |.. ... .    |.. ||||........    ...|.|.. .   .   . ... ..|     | . |. .   |. .||.|
lepevs.........vdirelelekgdllllytDGltearsekg....faeerleeiledlv...dseaqelaqkiveellelakgsngeDdiTvvvv
PP2C_2 Protein phosphatase 2C 307-524 7.1e-07 21.7 Pfam-A 46-185 (212) alignment 
Range on Protein: 307-524
Range on HMM: 46-185/212.0
AKEHLMLEIVKQKQFWSDQ-DEDVLRAIREGYIATHFamwREQEKWPRtaNGHLSTAGTTATVAFMRREKIYIGHVGDSGIVLGYqnkgeRNWRARPLTT
| | ..  . |. . .| | .|..||.|.... |.      .||.  .  .  |.  .|| ..|... ..|.....||..||.       |. ....|..
aveaagealeklleeeseqeeeallrqieneilasvk...lkqeaeaq..qeelkdyatTlllavitpgeivffqiGDgaivvrd.....rdgevqllge

DHKPESLAEKTRIQRS--GGNVaiksgvprvvwnrprdpmhrgpirrrtlvdeipflavarslgdlwsynsrfkefvvspdpDVKVVKinPSTFRCLIFG
... |   | |.....  ....                                                            ... .|   . ...|.  
pdsgeyanettfltsedaeeel............................................................rirrlk..lepgdalllm

TDGLWnvvtaqeavDSVRKEH
|||..         ||.|||.
TDGvs.........dslrkee
PP2C_2 Protein phosphatase 2C 307-524 7.1e-07 21.7 In-house 46-185 (212) alignment 
Range on Protein: 307-524
Range on HMM: 46-185/212.0
AKEHLMLEIVKQKQFWSDQ-DEDVLRAIREGYIATHFamwREQEKWPRtaNGHLSTAGTTATVAFMRREKIYIGHVGDSGIVLGYqnkgeRNWRARPLTT
| | ..  . |. . .| | .|..||.|.... |.      .||.  .  .  |.  .|| ..|... ..|.....||..||.       |. ....|..
aveaagealeklleeeseqeeeallrqieneilasvk...lkqeaeaq..qeelkdyatTlllavitpgeivffqiGDgaivvrd.....rdgevqllge

DHKPESLAEKTRIQRS--GGNVaiksgvprvvwnrprdpmhrgpirrrtlvdeipflavarslgdlwsynsrfkefvvspdpDVKVVKinPSTFRCLIFG
... |   | |.....  ....                                                            ... .|   . ...|.  
pdsgeyanettfltsedaeeel............................................................rirrlk..lepgdalllm

TDGLWnvvtaqeavDSVRKEH
|||..         ||.|||.
TDGvs.........dslrkee
subfamily_PDP_pd Subfamily PDP 358-420 2.5e-09 29.7 In-house 148-209 (398) alignment 
Range on Protein: 358-420
Range on HMM: 148-209/398.0
HLSTAGTTATVAFMRREKIYIGHVGDSGIVLGYQNkGERNWRARPLTTDHKPESLAEKTRIQR
. ...|..|..|... .....  .||.  ||| |. .| .| |..|..|.  .. .| .||..
lvalsGacallaliegtelhvAntGDcravlgvqe.eegsweavkLskdqtadneeEveRikk
subfamily_PPM1G_pd Subfamily PPM1G 361-427 1.3e-11 37.1 In-house 295-355 (473) alignment 
Range on Protein: 361-427
Range on HMM: 295-355/473.0
TAGTTATVAFMRREKIYIGHVGDSGIVLGYQnkgernWRARPLTTDHKPESLAEKTRIQRSGGNVAI
 .||||.|| .. .|...  .|||  ||  .       .|  | .|||||   |..||.. ||.|  
dsGttAvvaLlkekklivAnaGDsRcvlsrn......GkAldlslDHkPeDevEleRiekAGGkvde
subfamily_PPM1L_pd Subfamily PPM1L 459-525 1.7e-07 23.7 In-house 175-236 (269) alignment 
Range on Protein: 459-525
Range on HMM: 175-236/269.0
FLAVARSLGDlwsYNSRFKEFVVsPDPDVKVVKINPSTFRCLIFGTDGLWNVVTAQEAVDSVrKEHL
 ||..|.|||   |  . |..|. .|||.   ...    . ||. .||||.  . .|||  . ||.|
vlatsralGd...yplkdknlvi.adpdiltfdlddhkpeflilasdGlwdtfsneeavrfi.kerl
Subfamily Dicty-PPM1L-like 459-548 5.8e-06 18.3 In-house 204-289 (305) alignment 
Range on Protein: 459-548
Range on HMM: 204-289/305.0
FLAVARSLGDlwsynSRFKEFVVsPDPDVKVVKINPSTFRCLIFGTDGLWNVVTAQEAVDSVRKEHLIGEILN--EQDVMNPSKALVDQALK
.| . || ||        ||.|. |..| ..  .. .    |.  |||||.|.  |. |. |..   .  . .  | |  . |.  | .|.|
llkksrskGd.....knlkelvi.PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavk
subfamily_PPM1E_pd Subfamily PPM1E 460-569 2.5e-10 33.0 In-house 171-264 (265) alignment 
Range on Protein: 460-569
Range on HMM: 171-264/265.0
LAVARSLGDlwsynSRFKEFvVSPDPDVKVVKINpSTFRCLIFGTDGLWNVVTAQEAVDSVrKEHLIGeilNEQDVMNPSKALVDQAlktwaAKKMRADN
|.|.|..||      . |.. || ..||  |... ..  .|| ..||||.||. .|.|. | .|.|     ...| .. .| ||..|      ..  .||
LsvsRaiGD.....vklkpy.vsgeadvaeveld.gseeylilacDGlwDvvneeevvklv.eeflad...gaedlsevakllveaa.....keagssDn

TSVVTVILTP
 .|| |.| |
itvvvvfldp
subfamily_PPM1G2_pd Subfamily PPM1G2 460-567 7.2e-10 31.3 In-house 181-286 (287) alignment 
Range on Protein: 460-567
Range on HMM: 181-286/287.0
LAVARSLGDLWSYNS---RFKEFVVSPDPDVKVVKINpSTFRCLIFGTDGLWNVVTAQEAVDSVRKEhligeILNEQDVMNPSKALVDQALKTWAA-KKM
||..|.|||    ..   . .| .|   ||| | |.. .    |.   ||.|.|.| .| || ||..     . ..... . .. |.|..|.  .    .
LalsralgDfefkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrer.....lvsgakldeiieelldkclapdssntgv

RADNTSVVTVIL
 .|| .|| |.|
GcDnmtvvivvl
subfamily_ILKAP_pd Subfamily ILKAP 460-567 5.8e-08 25.2 In-house 185-289 (293) alignment 
Range on Protein: 460-567
Range on HMM: 185-289/293.0
LAVARSLGDLwsynsRFKEFVVSPDPDVKVVKINPStFRCLIFGTDGLWNVVTAQEAVDSVRKeHLIG----EILNEQDVMNPSKALVDQALKTWAAKKM
| |.||.||      |||.  |.  |||| .....   . ..   ||||.|..|.|.|. . |  |      . ..|..... ...  . | .  |.. .
levsrsiGdg.....rfkrlGvistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilk.vledeeddrkikeeekkskeevrfevacnrlaseav

RADNTSVVTVIL
. . .  |||.|
krgssdnvtvll
subfamily_PPM1G_pd Subfamily PPM1G 461-567 4e-07 22.4 In-house 364-470 (473) alignment 
Range on Protein: 461-567
Range on HMM: 364-470/473.0
AVARSLGDlWSYNS----RFKEFVVSPDPDVKVVKINPSTfRCLIFGTDGLWNVVTAQEAVDSVRKEHLIGEilnEQDVMNPSKALVDQALKTW-AAKKM
 ..| ||| ..| .      || ..|  ||.|| .. .     |.  .||.|||...|| || ||..   ||   |. . .  ..|.|..|         
nlsRAlGD.haYkkneeLplkeqmisAlPDikvltlteed.eFlvlAcDGiWnvmesqevvdfvraklkkge...esvlseiveeLlDaclapdtsgDGt

RADNTSVVTVIL
  || .|. |.|
GCDnmtviivll
subfamily_PDP_pd Subfamily PDP 483-569 4.5e-07 22.3 In-house 272-358 (398) alignment 
Range on Protein: 483-569
Range on HMM: 272-358/398.0
PDPDVKVVKINPSTfRCLIFGTDGLWNVVTAQEAVDSVrKEHLIGEIlNEQDV-MNPSKALVDQALKTWAAKKMRA--DNTSVVTVILTP
 .|.|   |..... . |...|||||.... .|.|. | .||| ..  ....| ....|. . |  .. . .|  .   .... | ..  
aePevtshklrend.kFLvlatDGLwdllsneevvslV.gehlakkk.ekepvkveeakltlkqvveelkerkrklkredknaAthLirh
PPM_PTC7_motif 503-556 6.6e-08 25.9 In-house 3-47 (51) alignment 
Range on Protein: 503-556
Range on HMM: 3-47/51.0
GTDGLWNVVTAQEAVDSVRKEHL-IGEilneqDVMNPSKALVDQALKTWaakkmR
..||||.|.. ||||| ||..    |.     . .. .. |||.||. .     .
AsDGLWDvlsdqeavdlvrdqlskkgl.....spqeaAeklvdealarg.....s