Gene CG10376 in Drosophila melanogaster

Synonym: Dmel\CG10376, PP2C, Dmel_CG10376, CG10376

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1E
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP130_AA protein Get Run
DmelP130_AA_155-421 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PP2Cc_SM00332 156-417 5.3e-60 196.1 In-house 8-274 (274) alignment 
Range on Protein: 156-417
Range on HMM: 8-274/274.0
KEPLHTSAAVKNKPRKMEDRCVCLDRFGemyelLDKTTRFFGVFDGHSGSLSATYATSQLPQLLADQLKANPDPAafsPDFYRNAFESAFLLADERFTQK
..  .  .. ......|||..|.  ..        . . ||||||||.||  | .. ..||. |...||   |      |   .| ..||| .||.....
lglsygkssmqgwrksmeDahvvvvdlv.....eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...eddveealkkaflstdeeilee

K-------ITSGTTSVCALITKDQLYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVLHAqgqwRVNGILNVARSIGDYSLE-------
.        .||.| |.||..|..||.|.||||.| |. ..  .|| . ||||..||||||..|||.|       |||| |.| |..||. |        
eqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg....rvngglavsrafGdhflkknkklke

-AVIAEPDFVDVQLNEAHDFLVLGTDGLWDHVPESLIIETVYDSLADT-TMKLDDIPKLLIEAAKER-DSQDNITAVVV
  ..||||   |.|.....||.| .|||||.. .  ....| . || . |.. ... .||.|.| .|  |.||||.|||
pyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_PPM1E_pd Subfamily PPM1E 158-421 4.1e-109 356.8 In-house 4-264 (265) alignment 
Range on Protein: 158-421
Range on HMM: 4-264/265.0
PLHTSAAVKNKPRKMEDRCVCLDRFGEMYELLDKTTR-FFGVFDGHSGSLSATYATSQLPQLLADQLKANPDPAafspdfyrNAFESAFLLADERFTQK-
  ...||||||.||||||.|.|....|..|| |...| ||.|||||.|. .|.||...|..||..| |.. |||        .|...|| |.||||.|| 
yevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa........ealkeafkltDerflqka

---KITSGTTSVCALITKDQLYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVLHAqGQWRVNGILNVARSIGDYSLEA-VIAEPDFVD
   |..||.|.|..||.|||||.||.|||.|||| |....||.||||||..||.||||.|||.|... |.|||||.|.|.|.|||..|.. |..|.|...
ereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvi.gawRvnGvLsvsRaiGDvklkpyvsgeadvae

VQLNEAHDFLVLGTDGLWDHVPESLIIETVYDSLADTTMKLDDIPKLLIEAAKERDSQDNITAVVVLLKP
|.|......|.|..|||||.|.|. ....|...|||....|....|||.|||||..|.||||.|||.|.|
veldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfldp
subfamily_PPM1G2_pd Subfamily PPM1G2 159-419 2e-42 138.1 In-house 20-286 (287) alignment 
Range on Protein: 159-419
Range on HMM: 20-286/287.0
LHTSAAVKNKPRKMEDRCVCLDRFGEMYEllDKTTRFFGVFDGHSGSLSATYATSQLPQLLADqlkanpdPAAFSPDFYRNAFESAFLLADERFTQK---
  .|.|..   ..|||  .  . . |...  ||.. .|.||||| |.  | ||...| . .|          .|. .  ..... |||  || ....   
kvgssamqGyrlnmeDahilenelleksd..dkslalfavfDGhGGakvakyagkklikkiak.......kksfkegaleqilkdafletDeellkdekl

-KITSGTTSVCALITKDQLYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVLHAqgqwRVNGILNVARSIGDYSLE----------AVI
 . ..|.|.| .||....||.| .|||.|.|  | .  .|   |||.. .|.|||. |||.|       |||| | ..|..||..             | 
kdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfveln....rvngnLalsralgDfefkknvkkkpeeqivt

AEPDFVDVQLNEAHDFLVLGTDGLWDHVPESLIIETVYDSLADTtMKLDDIPKLLIEAAKERDSQ------DNITAVVVLL
|.|| .  .|.| ..||||  ||.|| . .. ... |   |..  .|||.| . |.. .  .||.      ||.|.|.| |
avPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsg.akldeiieelldkclapdssntgvGcDnmtvvivvl
0034914 PP2C-like 162-421 4.3e-66 215.6 In-house 25-292 (295) alignment 
Range on Protein: 162-421
Range on HMM: 25-292/295.0
SAAVKNKPRKMEDRCVCLDRFGEMYElldkTTRFFGVFDGHSGSLSATYATSQLPQLLADQLKANPDPAAFSPDFYRNAFESAFLLADERFTQKKIT---
.| .... ...||..... ..  . |     . .|||||||.|.  | .| . |..||...|.     . .|.. ...|...||| |||.. .. .    
vasdqGrrksneDavlvvlnllslle....dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallrpe

---SGTTSVCALITKDQLYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVLHaqgqWRVNGILNVARSIGDYSLE----------AVIA
   |||| |.|||....||.|.||||.|.|. . . .|| . ||| |..||.||..|||.| |    .||||.|.| |..||..|           .|.|
lagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh....grvngvlavtRalGdfdlklllslllleplvsa

EPDFVDVQLN-EAHDFLVLGTDGLWDHVPESLIIETVYDSLAdTTMKLDDIPKLLIEAAKERDSQDNITAVVVLLKP
|||.  ..|. | .|||.|..|||||..... |.. |.. || ... |... . |...| .| |.||||.||| |..
ePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAlargsrDNiTvvvvrlng
subfamily_PPM1A_pd Subfamily PPM1A 163-419 1.3e-55 181.7 In-house 17-280 (282) alignment 
Range on Protein: 163-419
Range on HMM: 17-280/282.0
AAVKNKPRKMEDRCVCLDRFGEMyelldKTTRFFGVFDGHSGSLSATYATSQLPQLLADQ--LKAnPDPAAFSPDFYRNAFESAFLLADERFTQKK----
.....  ..|||. ..  ..|..     |. .|| |||||.||  |.|....|.. . ..  ||.     | . | ...|....|| .||.  ...    
ssmqgwrvemEDahtvvaslgal.....kdwsfFavfDGHaGsevakyvkkhllenileeeelke.aaleasekdevkealrqgfLaldeairelstdlk

--ITSGTTSVCALITKDQLYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVLhaqgQWRVNGILNVARSIGDYSLEA----------VI
    ||.|.|..|.....|.|| .|||.|.|. ....  | . |||..|.|.|||| |||.|.      |||| | |.|..|||...           |.
tadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGaLAvsRalGDyeykeeeekkaeeqlvs

AEPDFVDVQLNEAHDFLVLGTDGLWDHVPESLIIETVYDSLADTtMKLDDIPKLLIEAAKERDSQDNITAVVVLL
|||.   .. .| .|||||  ||.|| . .. ..| | ..|  .  .|  . | |.. | |..|.||....|||.
aepevtsierseeddflvlacDGiwDvlsdeevvelvrkrleva.deleevakalvdkalekgsrDNlsvlvvlf
subfamily_PPM1L_pd Subfamily PPM1L 165-420 2.6e-43 141.2 In-house 12-267 (269) alignment 
Range on Protein: 165-420
Range on HMM: 12-267/269.0
VKNKPRKMEDRcvcldrFGEMYELLDKT-TRFFGVFDGHSGSLSATYATSQLPQLLADQL-KANPDPAAFSPDFYRNAFESAFLLADERFTQKK----IT
|. .  .||||      |    .. .|| ..||.||||| | ..| .| . |.. . ..| . . |     |  . . ..   | .||.. .|      .
vlGrrprmedr......feieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedi

SGTTSVCALITKDQLYIAWVGDSKALLVGKRT-QLQLVKPHKPENPDERKRIETAGGTVlHAQGQWRVNGILNVARSIGDYSLE---AVIAEPDFVDVQL
.|||.. ||.....| .| ||||. .|. ||   . |   |||... |||||. ||| .   .| |||.|.| ..|..||| |     |||.|| .  .|
aGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfi.afrGvwrvaGvlatsralGdyplkdknlviadpdiltfdl

NEAH-DFLVLGTDGLWDHVPESLIIETVYDSLADTTMKLddipKLLIEAAKERDSQDNITAVVVLLK
.. . .||.| .|||||   .   .. . . | .  .      | |.  .  | | |||| .|| ||
ddhkpeflilasdGlwdtfsneeavrfikerlkepdfGa....kslvlesfkrGsvdnitvlvvklk
subfamily_ILKAP_pd Subfamily ILKAP 165-388 3.3e-37 121.2 In-house 12-246 (293) alignment 
Range on Protein: 165-388
Range on HMM: 12-246/293.0
VKNKPRKMEDRCVCLDRFGEMYELLDK---TTRFFGVFDGHSGSLSATYATSQLPQLLADQLKAnPDPAAFSpDFYRNAFESAFLLADERFTQKK-----
 | .  .|.| .| |. . |  .| ..      ...|||||.|| .. .|...| . . ..|    | .|      ....  .|   || | ..      
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsake.keikkclvdsfkktdeefLklaskakP

-ITSGTTSVCALITKDQLYIAWVGDSKALLVGKRT------QLQLVKPHKPENPDERKRIETAGGTVLHAqgqwRVNGILNVARSIGDY--SLEAVIAEP
    |.| .. |.  . ||.| .|||||.|| |        ...| | |.| . .|||||. |||.| .     ||.|.|.|.|||||       ||. |
vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg....rvlGvlevsrsiGdgrfkrlGvistP

DFVDVQLNEAHDFLVLGTDGLWDHVPESLIIETVYDSLADT
|   ..|.|   |.||  ||||. .  . ... . . | | 
dvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvlede
subfamily_PPM1D_pd Subfamily PPM1D 166-420 1.3e-31 102.8 In-house 10-308 (309) alignment 
Range on Protein: 166-420
Range on HMM: 10-308/309.0
KNKPRKMEDRCVCLdrFGEMYELLDKTTRFFGVFDGHSGSLSATYATSQLPQLLADQLKAnpdpAAFSPDFYRNAFESAFLLADERF-----------TQ
.   . |||...    . |  .....   |..||||| |   |..| ..| . . .| |      . .|.  ..| ..|||   |             ..
qGgrkymeDvvaiv..leeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf....lssepedvleAireaflatheamkkkleeWpktksg

KKITSGTTSVCALITKDQLYIAWVGDSKALLVGKRT------QLQLVKPHKPENPDERKRIETAGGTVLHAQGQWRV---------NG--------ILNV
.  |.|||  . .|....||.| ||||...|  |          .|.| ||||.|.|..|||..|| | . .|  ||         ||         |.|
llstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLav

ARSIGDY-SLEA------VIAEPDFVDVQLNEAHD-FLVLGTDGLWDHVPESLIIETVYDSLADTTMK---LDDIPKLLIEAAKERDSQ-----DNITAV
|||.||  | .|      |  ||| ....|. ... |..|..||||. .. .  ...| .. . ...|     .. | |.. | .| ..     ||....
aRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsvi

VVLLK
||.|.
vvile
0049733 PP2C-like 167-420 1.6e-50 164.6 In-house 13-234 (235) alignment 
Range on Protein: 167-420
Range on HMM: 13-234/235.0
NKPRKMEDRCVCldrfgemyelldkTTRFFGVFDGHSGSLSATYATSQLPQLLADQLKAnpdpaaFSPDFYRNAFESAFLLADERFTQKKIT------SG
.. . .||....              . .|.|.|||.|.  . .| ..|...|...|..      ...  ...|...||| |.|.. .. ..      .|
rvrkvneDavlv.............glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspelagmg

TTSVCALITKDQLYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVlhaqgqwRVNGILNVARSIGDYSLEaviaePDFVDVQLNEAHdF
|| |.||.....||.|.|||| |.|. . . .|| ..|.| |..||.||.|||| |       ||.|.| . |..||. |.     ||.. ..|.. . |
tTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav.......rvpgrlaltralGdlllk.....pdvtvlelepgd.f

LVLGTDGLWDHVPESLIIETVYDsladttMKLDDIPKLLIEAAKERDSQDNITAVVVLLK
|.| .|||||..... |.... .      . |... . |.|.| .| ..||||.||| |.
lllasDGlwdvlsdeeivdllrs......ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 168-419 5.1e-45 146.7 In-house 16-253 (255) alignment 
Range on Protein: 168-419
Range on HMM: 16-253/255.0
KPRKMEDRCVCLDRFGEmyellDKTTRFFGVFDGHSGSLSATYATSQLPQLLADQLKANPDPAAfspDFYRNAFESAFLLAderfTQKKITSGTTSVCAL
.   |||. |    | .     ..   .. .||||.|. .|..|. .|...||. |..|. .     . ...|...  ..     ... .  |||.. .|
rrptmedelviyGsfrd.....ksdedyyalfdGhgGraaakfaseelykilaelldlnnanPv...kslkkaykeistqi....serpkfiGttaasvl

ITKDQLYIAWVGDSKALLVGKR-TQLQLVKPHKPENPDERKRIETAGGTVLHAQGQWRVNGILNVARSIGDYSLEA-VIAEPDFV-DVQLNEAHDFLVLG
|..|. ||| ||||...|  |  |  .|   ||| ...|.|||. .||||. ..   |||| | |.|..||  ||  |...||.   ..  . . ||.| 
iiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflila

TDGLWDHVPESLIIETVYDSlADTtmklDDIPKLLIEAAKERDSQDNITAVVVLL
 ||.|| . .   .|.| .. .|.    ..  . | . | .. |.|||. .|. |
cdGiwdlisdeeaveivagi.sdp....ekaaeklrdlayssGstdnisvivikl
PPM_PTC7 169-412 5.5e-61 199.3 In-house 12-259 (259) alignment 
Range on Protein: 169-412
Range on HMM: 12-259/259.0
PRKMEDRCVCLDRFGEMyeLLDKTTRFFGVFDGHSGSLSATYATSQLPQLLADQLKANPDPaafspdFYRNAFESAFLL--ADERFTQ-----KKITSGT
 ..|||....|. .. .    ..  .||.||||| |.  |.|| ..|.. |. .   ...        . .|.  .||   .||....     ...|||.
rksmedahialanless..sgkdsvaffavfdghggreaakyarehleeilkerksfeele......klekalrksflaldtdeelksseantepstsGs

TSVCALITKDQLYIAWVGDSKALLVGKRTQL-QLVKPHKPENPDERKRIETAGGTVLHAqGQWRVNGILNVARSIGDYSLE-------AVIAEPDFVDVQ
| |.||||...||.|.||||.|.|.....   || . |||.|.|||.||| |||.| .  |..|||| |.|.|..||. |        .|.||||   ..
tAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnv.gngrvngvlavsRafGdfelkpketeeqlvsaePdisstk

LNEAHDFLVLGTDGLWDHVPESLIIETVYDSLADTtmKLDDIPKLLIEAAKERDSQDNI
..| ..||.|..|||||.|..  ... | . |...  ..... . |.. |..|.|.|||
ideedefliLasdGlwdvvsdqeavdlvrselskk..dpmeaaeklvdeaiargsedni
PP2C Protein phosphatase 2C 169-412 5.9e-61 199.3 Pfam-A 12-255 (255) alignment 
Range on Protein: 169-412
Range on HMM: 12-255/255.0
PRKMEDRCVCLDRFGEMyeLLDKTTRFFGVFDGHSGSLSATYATSQLPQLLADQLKANPDPaafspdFYRNAFESAFLL-ADERFTQ-----KKITSGTT
 ..|||....|. ....    ... .||.||||| |.  |.|| ..|...|. | . ...        ...|. ..||  .||....     . ..||.|
rksmedahialknleks..sgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelksskantepsksGst

SVCALITKDQLYIAWVGDSKALLVGKRTQL-QLVKPHKPENPDERKRIETAGGTVLHaqgQWRVNGILNVARSIGDYSLE-----AVIAEPDFVDVQLNE
.|.|||....||.|.||||.|.|. |...  .| . |||...|||.|||.|||.| .   ..|||| |.|.|..||. |      .|.||||   |.|.|
avvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn...ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklte

AHDFLVLGTDGLWDHVPESLIIETVYDSLADTTmKLDDIPKLLIEAAKERDSQDNI
 ..||.|..|||||....  ... | . | ... ..... . |.. |..| |.|||
edefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 169-412 5.9e-61 199.3 In-house 12-255 (255) alignment 
Range on Protein: 169-412
Range on HMM: 12-255/255.0
PRKMEDRCVCLDRFGEMyeLLDKTTRFFGVFDGHSGSLSATYATSQLPQLLADQLKANPDPaafspdFYRNAFESAFLL-ADERFTQ-----KKITSGTT
 ..|||....|. ....    ... .||.||||| |.  |.|| ..|...|. | . ...        ...|. ..||  .||....     . ..||.|
rksmedahialknleks..sgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelksskantepsksGst

SVCALITKDQLYIAWVGDSKALLVGKRTQL-QLVKPHKPENPDERKRIETAGGTVLHaqgQWRVNGILNVARSIGDYSLE-----AVIAEPDFVDVQLNE
.|.|||....||.|.||||.|.|. |...  .| . |||...|||.|||.|||.| .   ..|||| |.|.|..||. |      .|.||||   |.|.|
avvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn...ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklte

AHDFLVLGTDGLWDHVPESLIIETVYDSLADTTmKLDDIPKLLIEAAKERDSQDNI
 ..||.|..|||||....  ... | . | ... ..... . |.. |..| |.|||
edefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni
subfamily_KAPP-like_pd Subfamily KAPP-like 169-419 1.1e-27 89.8 In-house 9-266 (266) alignment 
Range on Protein: 169-419
Range on HMM: 9-266/266.0
PRKMEDRCVCLDRFGEMYELLDK-TTRFFGVFDGHSGSLSATYATSQLPQLLADQLKANPDPAAFSPD-FYRNAFESAFLLADERFTQKKITsGTTSVCA
. .|||  ..   ...  .| .     .|.|||||.|  .|  |   .|. | ..||   .     .    .. .| ||   |... . .   |.|.  |
stemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeye.Gatatla

LITKD--QLYI--AWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVlhAQGQWRVNGILnVARSIGDYSLE----AVIAEPDFVD-VQLNEA
|. .|  | |.  | |||| |.|      |.| | || ..|.|..||   | |.  ...| |.||.. |.|..||. .      .|.||   . . |   
lvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitl..sdnqtrinGla.vsralGdhfikelniGlisepyvsnrilltpf

HDFLVLGTDGLWDHVPESLIIETVyDSLADTTMKLDDIPKLLIEAA-KERDSQDNITAVVVLL
..||.. .||||| .     || | .|| |     |.. . |.|.| .   ..||.. .|| |
dkflivasdGlwdvisGkdaiekv.kslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 169-419 1.2e-24 79.7 In-house 8-276 (276) alignment 
Range on Protein: 169-419
Range on HMM: 8-276/276.0
PRKMEDRCVCLDRFGEMYELLDK-TTRFFGVFDGHSGSLSATYATSQLPQLLADQLKA------NPDPAAFSPDFYRNAFESAFLLADERFTQKKITsGT
. .|||  ..   ...  .| .     .|.|||||.|  .|  |   .|. |   ||.      . |    .    .. .  .|   |... . .   |.
stemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeye.Ga

TSVCALITKDQ----------LYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVlhAQGQWRVNGILnVARSIGDYSLE----AVIAEP
|.  ||. .|           | .| |||| |.|      |.| | || ..|.|..||   | |.  ...| |.||.. |.|..||. .      .|.||
tatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitl..sdnqtrinGla.vsralGdhfikelniGlisep

DFVD-VQLNEAHDFLVLGTDGLWDHVPESLIIETVyDSLADTTMKLDDIPKLLIEAA-KERDSQDNITAVVVLL
   . . |   ..||.. .||||| .     || | .|| |     |.. . |.|.| .   ..||.. .|| |
yvsnrilltpfdkflivasdGlwdvisGkdaiekv.kslydqqatedkmasslletaiqsikakdnvsvivvkl
PPM_PTC7_SpoIIE 170-395 2.8e-29 95.5 In-house 13-213 (230) alignment 
Range on Protein: 170-395
Range on HMM: 13-213/230.0
RKMEDRCVCLDRFGEMyeLLDKTTRFFGVFDGHSGSLsaTYATSQLPQLLADQLKANPDpaafspdFYRNAFESAFLLADERFTQKKITSGTTSVCALIT
..|||...... .. .    . .  ..|..||| |.   ..|...| ..|. . .|. .          .... ..|... ... . ..||.| |.|||.
ksmedahispanseks..sggrlalvvgdvdGhGgra..alamgllrtalrelafagle.......kpeeilrrlnlalaadledepsssgaTavvalid

KDQ--LYIAWVGDSKALLVGKRTQlqlvkphkpenpdERKRIeTAGGTVLHAQGQWRVNGILNVARSIGDYSLEA----VIAEPDFVDVQLNEAHDFLVL
 ..  ||.|..||| .||| . ..             ||.|| .||| .  . . .||.| |.|....||. | .    | |||| .|  | . ..||.|
pstgklyvanaGdsppllvrddgg.............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepdtsdgelfgkdeflil

GTDGLWDHVPESLIIETVYDSLADTtmklddI
..|||||...   ....| |.| .       .
asdglwdvlspqelvdlvrdelekp......a
subfamily_PP2D1_pd Subfamily PP2D1 171-225 2.4e-09 29.4 In-house 16-65 (492) alignment 
Range on Protein: 171-225
Range on HMM: 16-65/492.0
KMEDRCVCLDRFGEmyellDKTTRFFGVFDGHSGSLSATYATSQLPQLLADQLKA
||||. .  | ||.     |  . |||..||. |. .|  |...|...|...|. 
kmeDkrtlqdyfgn.....dvnscFfgiyDGynGataAeiaakelhevlleelek
subfamily_PPM1K_pd Subfamily PPM1K 180-420 2.1e-33 108.6 In-house 20-259 (263) alignment 
Range on Protein: 180-420
Range on HMM: 20-259/263.0
DRFgEMYElLDKTTRFFGVFDGHSGSLSATYATSQLPQLLADQLKANPDPAAFSPDFYRNAFESafLLADERF---TQKKITSGTTSVCALITK-DQLYI
||. .. | ||.   ...|||||.|| .| .. ..| . | . |. . |      . . .  .   |    .|    ... .||||.  .|. .  .| .
dri.klke.ldpellyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkk..lkrylefsvaeaellssGttatvsllrdGtelvl

AWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVL-HAQGQWRVNGILNVARSIGDYSLE--AVIAEPDFVDVQLNEAHD-FLVLGTDGLWDH
| .|||.|.|  .    .| . |.||  .|..|| .|||.|   . |. .||| | ..||.||  |    |||.|.   .... |.| |||| |||. . 
aslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfv

VPESLIIETVydslaDTTMKLDDIPKLLIEAAKERDSQDNITAVVVLLK
| .  . . |     .   . ..  . | |.| .  |.|| ||||| |.
vnsqelcdlv.....rlchdpeeaahalteqalqygsednatavvvplg
subfamily_PPM1G_pd Subfamily PPM1G 189-256 6.7e-09 28.2 In-house 43-103 (473) alignment 
Range on Protein: 189-256
Range on HMM: 43-103/473.0
LDKTTRFFGVFDGHSGSLSATYATSQLPQLLADQlkanpdpAAFSPDFYRNAFESAFLLADERFTQKK
||..| .|.|.||| |.  |.| ...||.|| .|        ..  .  ..|.| |||  ||. ....
ldedtslfavyDGHGGkevakyvakklpdllkaq.......kgykegdvekaleeaflalDeklkaee
PP2C_SIG_SM00331 190-417 1.1e-17 57.3 In-house 28-215 (217) alignment 
Range on Protein: 190-417
Range on HMM: 28-215/217.0
DKtTRFFGVFDGHSGSLSATYATSQLPQLLADQLKANpdpaafspdfyrNAFESAFLLADERFTQK--KITSGTTSVCALI--TKDQLYIAWVGDSKALL
.. . .. |.||. . | |  |.||| ..|  .|...            .....|.  ... . ..     ...| ..||.  ....|..| .|||  .|
eg.rlllvvaDgmGkGlaAaaassqlrtalrellseg............eelsqalkrlnraiyeekeekgmfaTlllalydfssgklsyanaGdsrpyl

VG-KRTQLQLVKphkpenpderkrietaggtvlhaqgqwrvngilNVARSIGDYSLEAviaePDFVDVQLNEaHDFLVLGTDGLWDHVPESL-----IIE
.. .... .|                                   .  . .|  . .     .|   ..|..  |.|.| ||||.. . |       ..|
lrdgklveilkd.................................vegaplGlepevs....vdirelelek.gdllllytDGltearsekgfaeerlee

TVYDSLADTTMKLDD-IPKLLIEAAKERDSQDNITAVVV
 . |.. ..  .|.. | . |.|.||..  .|.|| |||
iledlvdseaqelaqkiveellelakgsngeDdiTvvvv
subfamily_PHLPP_pd Subfamily PHLPP 192-419 2.5e-16 52.3 In-house 26-245 (246) alignment 
Range on Protein: 192-419
Range on HMM: 26-245/246.0
TTRFFGVFDGHSgslsATYATSQLPQLLADQLKANPDPAAFSPDFYRNafesAFLLADERFTQKKITSGTTSVCALITKDQ--------LYIAWVGDSKA
.   .|.|||..    ... .| |..|..| || .        .. .|     .| |  .  ..    |.. .  || .|.        | .| ||  .|
vealyGlfdGdr....neelssllqrlmkdvlkeevqkdkneeeymkn....tllvaqrklGeaGeklgsaallilirhdkvdPaksfsLevAsvGtlqa

LLVGKRTQLQLVKPHKPENPdERKRIETAGGTVlhaQGQWRVNGILNVARSIGDYSLE-AVIAEPDFVDVQLNEAHDFLVLGTDGLWDHvpesLIIETVY
 |. .  .|.| |... |.  | |||  | . .   . . ..||... .| .| ..|   |. .| . .|.|.|  ..|..| . ||..    | |. . 
vliRngkklrlsksyviekd.elkrikeakaii...tednkingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWev....lsideav

DSLADTTMKLDdIPKLLIEAAKERDSQDNITAVVVLL
... .    |  . | |.. |.  . .|.....|| |
eavrkeedplv.aAkklvdlaqsygaadsvsvlvvrl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 195-349 3.4e-23 75.6 In-house 22-196 (292) alignment 
Range on Protein: 195-349
Range on HMM: 22-196/292.0
F-FGVFDGHS--GSLSATYATSQLPQLLADQLkanPDPAAFSPDFYRNAFESAFLLaDERFTQKKITSGTTSVCALITKD-QLYIAWVGDSKALLVG---
|   |.|||   |   | .| ..| . | .     ..  . |. .  .  . |  | |. . ...  ..|. ||| .  | .|..| ||||.|||     
flaavldGhGvnGdkvaqlaedtlevellelt...rqlqelsealllrildiaakl.dkltidaresattavvcarvrddralilanvGdsrallgrclg

-KRTQLQ-LVKPHKPENPDERKRIETAGGTVL-------HAQGQWRV------NGILNVARSIGDYSLEA--VIAEPDF
  . .|. | . ||||.||||.||  ||| |          .|  ||      .| | ..|..||. | .  |.|||..
gsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePel
PP2C_2 Protein phosphatase 2C 198-377 1.3e-08 27.4 Pfam-A 29-186 (212) alignment 
Range on Protein: 198-377
Range on HMM: 29-186/212.0
VFDGHSGSLSATYATSQLPQLLADQLKANPDPAAFS-PDFYRNAFESAFL-----LADERFTQ-KKITSGTTSVCALITKDQLYIAWVGDSKALLVGKRT
| ||..    .  ..  . . ....|... . ....  .  ....|.. |      . .  .| .    .|| ..|.||.........||. ......  
VADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdg

QLQLV-KPHKPENPDERKRIETAggtvlHAQGQWrvngilnvarsigdysleaviaepDFVDVQlNEAHDFLVLGTDGLWDHVPESLI
..||. .|.. |   |  ..  .      |....                        ..  .. .|. | |.| |||..| . ..  
evqllgepdsgeyanettfltse.....daeeel........................rirrlk.lepgdalllmTDGvsdslrkeep
PP2C_2 Protein phosphatase 2C 198-377 1.3e-08 27.4 In-house 29-186 (212) alignment 
Range on Protein: 198-377
Range on HMM: 29-186/212.0
VFDGHSGSLSATYATSQLPQLLADQLKANPDPAAFS-PDFYRNAFESAFL-----LADERFTQ-KKITSGTTSVCALITKDQLYIAWVGDSKALLVGKRT
| ||..    .  ..  . . ....|... . ....  .  ....|.. |      . .  .| .    .|| ..|.||.........||. ......  
VADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdg

QLQLV-KPHKPENPDERKRIETAggtvlHAQGQWrvngilnvarsigdysleaviaepDFVDVQlNEAHDFLVLGTDGLWDHVPESLI
..||. .|.. |   |  ..  .      |....                        ..  .. .|. | |.| |||..| . ..  
evqllgepdsgeyanettfltse.....daeeel........................rirrlk.lepgdalllmTDGvsdslrkeep
subfamily_PPM1H_pd Subfamily PPM1H 240-310 1.1e-09 30.5 In-house 139-211 (404) alignment 
Range on Protein: 240-310
Range on HMM: 139-211/404.0
AFESAFLLADERFTQK----KITSGTTSVCALITKDQLYIAWVGDSKALLVGKRTQLQLVKPHKPENpdERKRIE
|.|||||  ||  ..     .|. | | . ||. ...||.|  |||.|.|| |..  .| . . ||   ||.|. 
alesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPet..eRqRlq
subfamily_TAB1_pd Subfamily TAB1 254-346 2.8e-16 52.2 In-house 124-218 (333) alignment 
Range on Protein: 254-346
Range on HMM: 124-218/333.0
QKKITSGTTSVCALITKDQLYIAWVGDSKALLVG---KRTQLQLVKPHKPENPDERKRIETAGGTVLHAQGQWRVnGILNVARSIGDYSLEAVIAE
...|. ||| | |||  ..||.| ||||.||||    .    || . |. .|.|| .|..  |  . . . . |. |  .  ||||||..     .
eeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrl.gskentRsiGdykvkkgykd
subfamily_PDP_pd Subfamily PDP 254-312 8.1e-08 24.8 In-house 147-210 (398) alignment 
Range on Protein: 254-312
Range on HMM: 147-210/398.0
QKKITSGTTSVCALITKDQLYIAWVGDSKALLV-----GKRTQLQLVKPHKPENPDERKRIETA
 .. .||.....||| ...|..| .||..|.|      |...  .| | .  .|..| .||...
llvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikke
subfamily_PPM1G_pd Subfamily PPM1G 259-421 5.5e-29 94.5 In-house 296-472 (473) alignment 
Range on Protein: 259-421
Range on HMM: 296-472/473.0
SGTTSVCALITKDQLYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVlhaQGQWRVNGILNVARSIGDYSLE----------AVIAEPD
|||| | ||. ...|..| .|||.. |  . . |.|   ||||.. |..||| |||.|   . . |||| ||..| .||..             . | ||
sGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkv...dedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPD

FVDVQLNEAHDFLVLGTDGLWDHVPESLIIETVYDSLADTT-MKLDDIPKLLIEAAKERDSQ------DNITAVVVLLKP
    .| |...|||| .||.|. .    ... | . |....  .| .| . |..|.   | .      || |...||||.
ikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
subfamily_PP2D1_pd Subfamily PP2D1 262-386 6e-23 74.3 In-house 179-307 (492) alignment 
Range on Protein: 262-386
Range on HMM: 179-307/492.0
TSVCALITKDQLYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVLHAQGQWRVNGILNVARSIG---DYSL-EAVIAEPDFVDVQLNEA
.|   |. .  |||| .|. .|.|. .    .| . | |.|. ||.|.| ||..|  .. . .|||||.. | .|   |  | ..|| || .  |.|.||
gsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldea

HDFLVLGTDGLWDHVPESLIIETVYDSLA
  |||| . |||. . |  ... | . ||
aqflvlAsnGlWevlseeevlsLvkqtla
Subfamily Dicty-PPM1L-like 304-420 5.9e-17 54.4 In-house 181-304 (305) alignment 
Range on Protein: 304-420
Range on HMM: 181-304/305.0
DERKRIETAGGTVLHaQGQWRVNGILNVARSIGDYSLEAVIAEPDFVD-VQLNEAHD-FLVLGTDGLWDHVPESLIIETVYDSLADTTMKL------DDI
..| ||| .......  |. .||..|.. ||.|| .|. ... ..      ...| | |||| |||||. .    ..| | . | |....       ..|
eiririeslqaalyn.ygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfnei

PKLLIEAAKERDSQDNITAVVVLLK
 ..  | | .|.|.|||| |.. ||
srviveeavkrgsgDnitlviiklk
subfamily_PDP_pd Subfamily PDP 343-391 5.5e-10 31.9 In-house 270-318 (398) alignment 
Range on Protein: 343-391
Range on HMM: 270-318/398.0
VIAEPDFVDVQLNEAHDFLVLGTDGLWDHVPESLIIETVYDSLADTTMK
..|||. .  .|.|.  ||||.|||||| . .. ....| . ||... |
ltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkek
subfamily_PPTC7_pd Subfamily PPTC7 356-412 1.8e-06 20.5 In-house 165-221 (252) alignment 
Range on Protein: 356-412
Range on HMM: 165-221/252.0
EAHDFLVLGTDGLWDHVPESLIIETVYDSLADTTMKLDDIPKLLIEAAKERDSQDNI
.  | .||.||||.| ..|. |.|.. .  . .. .|  . | |.|.|.|   . ..
kkgDiivlatDGlfDNlledeileilkelkeseksslqslakklaekarelsldpey
PPM_PTC7_SpoIIE_motif 357-417 7e-07 22.9 In-house 11-78 (81) alignment 
Range on Protein: 357-417
Range on HMM: 11-78/81.0
AHDFLVLGTDGLWDHV-------PESLIIETVYDSladTTMKLDDIPKLLIEAAKERD---SQDNITAVVV
. | |.|.||||..         ..   .... .    . ..|... . |.....|..   ..|.|| .|.
pgdvllLyTDGltEardsdgelfgkeellrladra...egkslqeladklvdevlengsgereDDitllvl
PPM_PTC7_motif 362-412 1.5e-07 24.8 In-house 1-51 (51) alignment 
Range on Protein: 362-412
Range on HMM: 1-51/51.0
VLGTDGLWDHVPESLIIETVYDSLADTTMKLDDIPKLLIEAAKERDSQDNI
.|..|||||....  ... | | |...  ..  . . |.. | .| | |||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni