Gene CG17746 in Drosophila melanogaster

Synonym: Cg17746, Dmel\CG17746, PP2C, Dmel_CG17746, CG17746

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1Z
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP132_AA protein Get Run
DmelP132_AA_2-284 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 3-284 5.7e-83 270.9 In-house 2-290 (295) alignment 
Range on Protein: 3-284
Range on HMM: 2-290/295.0
QTLSEPVTAKESAYCQNAAYRVGSSCMQGWRINMEDSHTHILSLPD-DPGAAFFAVYDGHGGATVAQYAGKHLHKYVLK--------RPEYNDNIEQALQ
..|| |.. . . . ..  .|||....||.| ..||.....|.|.  ... ..|.|.||||| ..|..| ..|....|.        .... ..||.||.
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

QGFLDIDYVMLRNKTC--GDQMAGSTAVVVLVKDNKLYCANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGGWVEFNRVNGNLALSRALGDYVF
..|| .|. .|.       ... |.||||.|...||||.||.|||||. . ||.|. |. ||||.|| | .||.. ||.| ..||||.||..|||||. .
kaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl

K-HENKKPEDQIVTAFPDVETRKIM-DDWEFIVLACDGIWDVMSNAEVLEFCRTRIGMGMFPEEICEELMNHCLApdcqmgGLGGDNMTVVLVCL
| . .  .....|.|.||| ....  .|..|..||.||.|||.|| |.....|...  |. .||..|||....||      . . ||.|||.|.|
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla......rgsrDNiTvvvvrl
subfamily_PPM1G2_pd Subfamily PPM1G2 4-285 2.3e-138 453.0 In-house 1-287 (287) alignment 
Range on Protein: 4-285
Range on HMM: 1-287/287.0
TLSEPVTAKESAYCQNAAYRVGSSCMQGWRINMEDSHTH---ILSLPDDPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEYN-DNIEQALQQGFLDI
||||||.|||||.|.||...||||.|||.|.||||.|..   .|...||. .|.|||.||||||.||.||||.|.|.. |..... ...||.|...||..
tlsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaflet

DYVMLRNKTCGDQMAGSTAVVVLVKDNKLYCANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGGWVEFNRVNGNLALSRALGDYVFKHEN-KKP
|  .|..... |..|||||||||.|..|||.||||||||.....|... ||.||||..|.|.||||. ||.||.|||||||||||||||..||... |||
DeellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkp

EDQIVTAFPDVETRKIMDDWEFIVLACDGIWDVMSNAEVLEFCRTRIGMGMFPEEICEELMNHCLAPDCQMGGLGGDNMTVVLVCLL
|.|||||.|||...|...|.||.||||||||||..|.||....|.|. .|. ..||.|||...|||||....|.| ||||||.|.||
eeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvll
subfamily_PPM1G_pd Subfamily PPM1G 5-104 2.5e-25 82.4 In-house 2-100 (473) alignment 
Range on Protein: 5-104
Range on HMM: 2-100/473.0
LSEPVTAKESAYCQNAAYRVGSSCMQGWRINMEDSHTHILSLPDDpgAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEYN-DNIEQALQQGFLDIDYVM
||.| . |||    |   ..| | ||||| ..||.|. |. | .|   ..|||||||||. ||.|  |.| . . ..  |. ...|.||.. ||..|  .
lskpkvekesedesneelsygasamqGwrvsqEDahncitdlded..tslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDekl

L
 
k
PP2Cc_SM00332 17-282 1.6e-85 279.8 In-house 5-274 (274) alignment 
Range on Protein: 17-282
Range on HMM: 5-274/274.0
CQNAAYRVGSSCMQGWRINMEDSHTHILSLPDDPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEYNDN-----IEQALQQGFLDIDYVMLRNKTCGD
 .|. .. | |.||||| .||| |  ...|    ...||.|.|||||. ||... |.|.... ..... ..     .|.||...||..|  .| ..    
gsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqske

Q---MAGSTAVVVLVKDNKLYCANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGGWVEFNRVNGNLALSRALGDYVFKHENkKPEDQIVTAFPD
.    .||||||.|.|...||.||.|||||. | ||.   || ||||..| |.||| . ||.||..||||.||.|||.||. .|. . |......|| ||
lenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk.klkepyitaepd

VETRKIMDDWEFIVLACDGIWDVMSNAEVLEFCRTRI--GMGMFPEEICEELMNHCLAPdcqmgGLGGDNMTVVLV
|.. .. ...||..||.||.|||.|| || ...| ..  |  . |.|..|.|......      | . ||.|||.|
vkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr.....ggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 18-284 9.1e-87 284.0 In-house 8-280 (282) alignment 
Range on Protein: 18-284
Range on HMM: 8-280/282.0
QNAAYRVGSSCMQGWRINMEDSHTHILSLPDDPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEY---------NDNIEQALQQGFLDIDYVMLRNKT
... .|.| | |||||..|||.|| . ||.  .. .||||.|||.|..||.|. |||.. .|.. |.         .|....||.||||..|  . ...|
egnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelst

CGD--QMAGSTAVVVLVKDNKLYCANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGGWVEFNRVNGNLALSRALGDYVFKH-ENKKPEDQIVTA
  .  . .|||||.|||....|..||.|||||. | ||. . |. ||||... | ||| | || |  .||||.||.||||||| .|. |.||.|.| |.|
dlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsa

FPDVETRKIMDDWEFIVLACDGIWDVMSNAEVLEFCRTRIGMGMFPEEICEELMNHCLAPDCQmgglggDNMTVVLVCL
 |.|.. .. .. .|.||||||||||.|..||.|. |.|....  .||....|....|  . .      ||..|..|..
epevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsr......DNlsvlvvlf
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 21-263 8.4e-47 152.6 In-house 5-238 (255) alignment 
Range on Protein: 21-263
Range on HMM: 5-238/255.0
AYRVGSSCMQGWRINMEDSHTHILSLPDDPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEYNDN-IEQALQQGFLDIDYVMlrNK-TcgdQMAGSTA
 ..|| | | | |  |||. .   |  |...  ..|..||||| . |..| ..|.| . .  . |.   ...|.. . .|.  .  .. .   .. |.||
rfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi..serp...kfiGtta

VVVLVKDNKLYCANAGDSRAIAC-VNGQLEVLSLDHKPNNEAESKRIIQGGGWVEFN----RVNGNLALSRALGDYVFKhenkkPedqIVTAFPDVE-TR
..||. ..| | || ||||.. |  .|  . |||||||..| | ||| . || |  .    ||||.||.||||||  ..     |    |.. ||.. . 
asvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle.....P...fvvpdPdlsqsl

KIMDDWEFIVLACDGIWDVMSNAEVLEFCRTrigMgMFPEEICEELMNHCL
.|. . .|..||||||||..|. |  |   .   .   ||. .|.| ..  
eiskkdkflilacdGiwdlisdeeaveivag...i.sdpekaaeklrdlay
0049733 PP2C-like 22-284 1.5e-59 194.0 In-house 3-233 (235) alignment 
Range on Protein: 22-284
Range on HMM: 3-233/235.0
YRVGSSCMQGW-RINMEDSHTHilslpddpGAAFFAVYDGHGGATVAQYAGKHLHKYVLK--RPEYNDNIEQALQQGFLDIDYVMLRNKTC--GDQMAGS
..|| ....|. | ..||..          | ..|||.|||||. ....| ..|....|.  .. .  ..|.||.. || .. ..|.  .   . .. |.
lsvgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgt

TAVVVLVKDNKLYCANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGGWVefnRVNGNLALSRALGDYVFKhenkkpedqivtafPDVETRKIMD
||||.|. ..|||.||.|||||. . .|.|. |. ||.|.|| | .|||. ||.|   ||.| |||.|||||. .|              ||| . .. .
TavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk..............pdvtvlelep

DWeFIVLACDGIWDVMSNAEVLEFCRTrigmgMFPEEICEELMNHCLApdcqmgGLGGDNMTVVLVCL
.  |..||.||.|||.|. |.....|.     . .||..|.|....||      . | ||.|||.|.|
gd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala......rggrDNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 22-284 5.6e-54 176.1 In-house 4-262 (265) alignment 
Range on Protein: 22-284
Range on HMM: 4-262/265.0
YRVGSSCMQGWRINMEDSHTHILS------LPDDPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEYNDNIEQALQQGFLDIDYVMLRNKTCGDQMAG
|.| . .... |  ||| |  . .      | |..  |||||.|||||   |.|| .|||. . .... ... ..||...|  .|  .|.  .     .|
yevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklksG

STAVVVLVKDNKLYCANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGGWV---EFNRVNGNLALSRALGDYvfkheN-KkpedQIVTAFPDVET
|||||||.. ..|| |  |||.|. . .|.   |   |||..| | ||| . || |   .  ||||.|..|||.||.     . |    . |.. .|| .
stavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDv.....klk....pyvsgeadvae

RKIMDDWEFIVLACDGIWDVMSNAEVLEFCRTRIGMGM-FPEEICEELMNHCLAPDCQmgglggDNMTVVLVCL
 .. .. |...|||||.|||. . ||..  .  .  |    .|. ..|...    . .      ||.|||.| |
veldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagss......Dnitvvvvfl
PPM_PTC7 23-267 1.8e-78 256.6 In-house 2-255 (259) alignment 
Range on Protein: 23-267
Range on HMM: 2-255/259.0
RVGSSCMQGWRINMEDSHTHILSLP---DDPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEYNDN--IEQALQQGFLD--IDYVMLRNK--TcGDQM
..|.|..||.| .|||.|..   |    ..   |||||.||||| ..|.||..||.. . .|.. ..    |.||  .||   .|... . .  | ... 
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseant.epst

AGSTAVVVLVKDNKLYCANAGDSRAIACVNGQLE-VLSLDHKPNNEAESKRIIQGGGWVE---FNRVNGNLALSRALGDYVFKHENKkpEDQIVTAFPDV
 ||||||.|. ..|||.||.|||||. | .|.    |. ||||.|| | .|| . ||.|.   ..||||.||.|||.||. .|   .  | | |.| ||.
sGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket..eeqlvsaePdi

ETRKIMDDWEFIVLACDGIWDVMSNAEVLEFCRTRIGMGmFPEEICEELMNHCLAPDC
...|| ...||..||.||.|||.|. |. ...|...  .  |.|..|.|.....|...
sstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargs
PP2C Protein phosphatase 2C 23-267 1.5e-77 253.6 Pfam-A 2-251 (255) alignment 
Range on Protein: 23-267
Range on HMM: 2-251/255.0
RVGSSCMQGWRINMEDSHTHILSL---PDDPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEYNDN--IEQALQQGFLD-IDYVMLRNK--TcGDQMA
.||.|..||.| .|||.|... .|    ..   |||||.|||||  .|.||..||.. . .... ..    |.||...||  .|... ..|  |  ..  
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskant.epsks

GSTAVVVLVKDNKLYCANAGDSRAIACVNGQLE-VLSLDHKPNNEAESKRIIQGGGWVE-FNRVNGNLALSRALGDYVFKHENkkpeDQIVTAFPDVETR
||||||.|....|||.||.|||||. | ... .  |. ||||..| | .|| . ||.|. ..||||.||.||||||. .| ..     |.|.| |||...
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke....eqlvsaePdvtsv

KIMDDWEFIVLACDGIWDVMSNAEVLEFCRTRIGMGMFPEEICEELMNHCLAPDC
|. ...||..||.||.|||.|. |. ...| ..  .  |.|..|||.....|. .
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargs
PP2C Protein phosphatase 2C 23-267 1.5e-77 253.6 In-house 2-251 (255) alignment 
Range on Protein: 23-267
Range on HMM: 2-251/255.0
RVGSSCMQGWRINMEDSHTHILSL---PDDPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEYNDN--IEQALQQGFLD-IDYVMLRNK--TcGDQMA
.||.|..||.| .|||.|... .|    ..   |||||.|||||  .|.||..||.. . .... ..    |.||...||  .|... ..|  |  ..  
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskant.epsks

GSTAVVVLVKDNKLYCANAGDSRAIACVNGQLE-VLSLDHKPNNEAESKRIIQGGGWVE-FNRVNGNLALSRALGDYVFKHENkkpeDQIVTAFPDVETR
||||||.|....|||.||.|||||. | ... .  |. ||||..| | .|| . ||.|. ..||||.||.||||||. .| ..     |.|.| |||...
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke....eqlvsaePdvtsv

KIMDDWEFIVLACDGIWDVMSNAEVLEFCRTRIGMGMFPEEICEELMNHCLAPDC
|. ...||..||.||.|||.|. |. ...| ..  .  |.|..|||.....|. .
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargs
PPM_PTC7_SpoIIE 23-264 4.3e-45 147.3 In-house 2-223 (230) alignment 
Range on Protein: 23-264
Range on HMM: 2-223/230.0
RVGSSCMQGWRINMEDSHTHILSL---PDDPGAAFFAVYDGHGGATvaQYAGKHLHKYVLKRPEYNDN-IEQALQQGFLDIDYVM--LrnktcgDQMAGS
..|.|..||.| .|||.|..   .   ...  |......|||||    ..| ..|.. . ..   . .  |..|. ..| ..  .         ..  |.
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlalaadlede......psssga

TAVVVLVKDNK--LYCANAGDSRAIACVN-GQlevlsldhkpnneaESKRIiQGGGWVE----FNRVNGNLALSRALGDYVFKHenkkpEDQIVTAFPDv
||||.|.  ..  ||.||||||... . . |.              | .|| ..||...    ..||.|.||.|.| ||. ...     .|..|.| || 
TavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly.....tDGvveaepd.

ETRKIMDD-WEFIVLACDGIWDVMSNAEVLEFCRTRIGMGmfpeeICEELMNHCLA
  ...... .||..||.||.|||.|..|.....| ...       ..|.|. ....
tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDit
subfamily_PPM1D_pd Subfamily PPM1D 23-173 3.5e-27 88.3 In-house 3-173 (309) alignment 
Range on Protein: 23-173
Range on HMM: 3-173/309.0
RVGSSCMQGWRINMEDSHTHILSLPD---DPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEY----NDNIEQALQQGFLDIDYVMLRNK-------T
.| |.. || |  |||  .  |.  .   . . ||.||.|||||   |..| .|| ... |. ..    .... .|....||..   | ...       .
svtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktks

CGDQMAGSTAVVVLVKDNKLYCANAGDSRAIACVNGQ------LEVLSLDHKPNNEAESKRIIQGGGWVEF
     ||.|| ||.....||| |. |||...  |. .       ..|  ||||.. .| .|| . || |  
gllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
subfamily_PPM1K_pd Subfamily PPM1K 24-284 1.2e-39 129.0 In-house 6-258 (263) alignment 
Range on Protein: 24-284
Range on HMM: 6-258/263.0
VGSSCMQGWRINMEDShTHILSLpdDPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEYNDNIEQALQQGFLDIDYVMLRNKTC-----GDQMAGSTA
||   ..| | . ||   ... |  ||   ..||.|||.|.. |... ..|.| . .  | ....|. |.. |...|  . |  .        . .|.||
vGkdsliGkraenedr.iklkel..dpellyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGtta

VVVLVKD-NKLYCANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGGWVEFN-----RVNGNLALSRALGDYVFKHENkkpedqiVTAFPDVETR
 |.|..| ..|  |. |||||| | ||. . |. ||.|. | | .|| . || ||.|     .||| ||..|.|||  .|.         | | |.  . 
tvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG.......viatPetksl

KI-MDDWEFIVLACDGIWDVMSNAEVLEFcrtrIGMGMFPEEICEELMNHCLapdcQMGglGGDNMTVVLVCL
|.  ..  |.||  ||| .|... |. ..    . .   |||  . | .  |    | |    || |.|.| |
kvdhaadsflvlitdgisfvvnsqelcdl....vrlchdpeeaahalteqal....qyg..sednatavvvpl
subfamily_PPM1L_pd Subfamily PPM1L 25-248 2e-46 151.4 In-house 8-239 (269) alignment 
Range on Protein: 25-248
Range on HMM: 8-239/269.0
GSSCMQGWRINMEDSHTHILSLPDDPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRP-EYNDN--------IEQALQQGFLDIDYVMLRNKTCGDQMAG
   ...| | .|||  .    . .. |  ||||.||||| . |..| . | | ....  |.. .         .. |..  | .|. .| . .   ..||
avysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaG

STAVVVLVKDNKLYCANAGDSRAIAC-VNGQLEVLSLDHKPNNEAESKRIIQGGGWVEFN---RVNGNLALSRALGDYVFKHENkkpedqIVTAFPDVET
.||.. ||....|  || |||| . .  .|.   || ||||..  | ||| . ||.. |.   ||.| || ||||||| .|..|      .| | ||. |
ttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdkn......lviadpdilt

RKIMD-DWEFIVLACDGIWDVMSNAEVLEFCRTRIGMG
 .. | . ||..||.||.|| .|| | ..| . |..  
fdlddhkpeflilasdGlwdtfsneeavrfikerlkep
subfamily_ILKAP_pd Subfamily ILKAP 27-245 4.4e-40 130.6 In-house 10-243 (293) alignment 
Range on Protein: 27-245
Range on HMM: 10-243/293.0
SCMQGWRINMEDSHTHILSLPDD--------PGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPE------YNDNIEQALQQGFLDIDY--VMLRNKTCG
.. .| | .|.|.|. . .| ..          ....||.|||.|   ...| ..||| .|..         . .| ..| . |   |   . | .|.  
aerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakP

DQMAGSTAVVVLVKDNKLYCANAGDSRAIACVN-GQLE-----VLSLDHKPNNEAESKRIIQGGGWVEFNRVNGNLALSRALGDYVFKHENkkpedqiVT
    ||||.|||| || || || |||.|. . .  . .     ||. ||.| .. | ||| . || |. .||.| |  ||..||  ||.         |.
vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG.......vi

AFPDVETRKIMDDWEFIVLACDGIWDVMSNAEVLEFCRTRI
. |||.  .. ..  |.||||||.|.|.|. ||..|.   .
stPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvl
Subfamily Dicty-PPM1L-like 28-77 1.9e-06 19.9 In-house 13-62 (305) alignment 
Range on Protein: 28-77
Range on HMM: 13-62/305.0
CMQGWRINMEDSHTHILSLPDDPGAAFFAVYDGHGGATVAQYAGKHLHKY
  .. | . || .   .|| ..    .| |.|||.|   |.|. |.| . 
vsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklvei
subfamily_PP2D1_pd Subfamily PP2D1 31-82 2.2e-10 32.9 In-house 12-63 (492) alignment 
Range on Protein: 31-82
Range on HMM: 12-63/492.0
GWRINMEDSHTHILSLPDDPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRP
 |. .||| .|      .|.  .||..|||. ||| |. | |.||. .|.. 
rWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleel
subfamily_KAPP-like_pd Subfamily KAPP-like 34-284 1e-24 80.0 In-house 10-266 (266) alignment 
Range on Protein: 34-284
Range on HMM: 10-266/266.0
INMEDSHTHILSLPDDPG------AAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEY--NDNIE--QALQQGFLDIDYVMLRNKTCGDQMAGSTAVVVLV
..||| .  |  | ..         |.|||.||| |  .|. | | . | . |  .   .|.    .  |.. |.  .  . .|    .  |.|| ..||
temedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlalv

KD----NKLYCANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGGWVEF--NRVNGnLALSRALGDYVFKHENKKpedqiVTAFPDVETRKIM-D
        | .|| ||| |. .   .   || ||| ... | .|| . |  .     |.|| ||.||||||.  |. |       ... | |  | ..  
wsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniG.....lisepyvsnrilltp

DWEFIVLACDGIWDVMSNAEVLEFCRTrigmgMFPEEICEELMNHCLAPDCQMGGLGGDNMTVVLVCL
  .|...| ||.|||.|  . .|  ..     .. ..  |. |  .|        .  ||..|..| |
fdkflivasdGlwdvisGkdaiekvks.....lydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 34-284 6.6e-21 67.4 In-house 9-276 (276) alignment 
Range on Protein: 34-284
Range on HMM: 9-276/276.0
INMEDSHTHILSLPDDPG------AAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEY-------NDNIEQ--ALQQGFLDIDYVMLRNKTCGDQMAGSTA
..||| .  |  | |.         |.|||.||| |  .|. | | . | ..|  .        .|.  .    |.. |   .  . .|    .  |.||
temedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGata

VVVLVKDNK----------LYCANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGGWVEF--NRVNGnLALSRALGDYVFKHENKKpedqiVTAF
 ..||  .           | .|| ||| |. .   .   || ||| ..  | .|| . |  .     |.|| ||.||||||.  |. |       ... 
tlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniG.....lise

PDVETRKIM-DDWEFIVLACDGIWDVMSNAEVLEFCRTrigmgMFPEEICEELMNHCLAPDCQMGGLGGDNMTVVLVCL
| |  | ..    .|...| ||.|||.|  . .|  ..     .. ..  |. |  .|        .  ||..|..| |
pyvsnrilltpfdkflivasdGlwdvisGkdaiekvks.....lydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_PDP_pd Subfamily PDP 36-82 3.6e-06 19.3 In-house 11-55 (398) alignment 
Range on Protein: 36-82
Range on HMM: 11-55/398.0
MEDSHTHILSLPDDpgAAFFAVYDGHGGATVAQYAGKHLHKYVLKRP
.||...   .|  .  . .|.| ||||||. |.   |.| ||| .  
iEDrrseakllesn..gvlfgvfDGHggaacaeavskrLlkyvaasl
PP2C_SIG_SM00331 46-282 5.5e-13 42.0 In-house 26-215 (217) alignment 
Range on Protein: 46-282
Range on HMM: 26-215/217.0
LPDDpgAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEYNdnieQALQQGFLDIDYVMLRNKTCGDQMAGSTAVVVLVKDNKLYCANAGDSRAIACVnGQ
|...    ...| ||.|.   |. | . |.. . .  . .    ..|.| .  .. .. ..|..... |  .. ..  ...||. ||||||| .     .
lneg..rlllvvaDgmGkGlaAaaassqlrtalrellseg....eelsqalkrlnraiyeekeekgmfaTlllalydfssgklsyanaGdsrpyllr.dg

LEVLSLDHkpnneaeskriiqgggwvefnrvngnlALSRALGDYVF-KhenkkpedqivtafPDVETRKIMDdWEFIVLACDGIWDVMS-----NAEVLE
 .|  |..                            ....||  .  .              .|......    ....|. ||.....|     .... |
klveilkd...........................vegaplGlepevs..............vdirelelek.gdllllytDGltearsekgfaeerlee

FCRTRIgmGMFPEEICE----ELMNHCLAPDCqmgglgGDNMTVVLV
. ..    .. ..|. .    ||...  ..         |..|||.|
iledlv..dseaqelaqkiveellelakgsng......eDdiTvvvv
PP2C_2 Protein phosphatase 2C 48-240 1.6e-06 20.6 Pfam-A 20-190 (212) alignment 
Range on Protein: 48-240
Range on HMM: 20-190/212.0
DDPGAAFFAVYDGHGGATVAQ----YAGKHLHKYVLKRPEYND-N-IEQALQQGFLDIDYVM-----LRNKTCGDQMAGSTAVVVLVKDNKLYCANAGDS
.. .. ..|| ||.| |  ..    .| . . ... |  | .. . .|..|.|   .|.  .        . .  .  ..| .............. ||.
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDg

RA-IACVNGQLEVLSLDHKpnNEAESKriiqgggwveF-----------NrvngnlalsralgdyvfkhenkkpedqivtafpDVETRKiMDDWEFIVLA
.. .   .|....|. ...  .|....          .                                             .... | ... . ..| 
aivvrdrdgevqllgepds..geyane..........ttfltsedaeeel.................................rirrlk.lepgdalllm

CDGIWDVMSNAE-VLEF
 ||..| ... | . |.
TDGvsdslrkeepfrel
PP2C_2 Protein phosphatase 2C 48-240 1.6e-06 20.6 In-house 20-190 (212) alignment 
Range on Protein: 48-240
Range on HMM: 20-190/212.0
DDPGAAFFAVYDGHGGATVAQ----YAGKHLHKYVLKRPEYND-N-IEQALQQGFLDIDYVM-----LRNKTCGDQMAGSTAVVVLVKDNKLYCANAGDS
.. .. ..|| ||.| |  ..    .| . . ... |  | .. . .|..|.|   .|.  .        . .  .  ..| .............. ||.
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDg

RA-IACVNGQLEVLSLDHKpnNEAESKriiqgggwveF-----------NrvngnlalsralgdyvfkhenkkpedqivtafpDVETRKiMDDWEFIVLA
.. .   .|....|. ...  .|....          .                                             .... | ... . ..| 
aivvrdrdgevqllgepds..geyane..........ttfltsedaeeel.................................rirrlk.lepgdalllm

CDGIWDVMSNAE-VLEF
 ||..| ... | . |.
TDGvsdslrkeepfrel
subfamily_PHLPP_pd Subfamily PHLPP 53-240 3.1e-09 29.1 In-house 28-211 (246) alignment 
Range on Protein: 53-240
Range on HMM: 28-211/246.0
AFFAVYDGHGGATVAQYAGKHLHKYVLKRPEYNDNIEQALQQGFLdidyvmLRNKTCGD--QMAGSTAVVVLVKDNK--------LYCANAGDSRAIACV
| . ..||.    ...   . ......   . . | |. ... .|        .. .|   .  ||.|...|.. .|        |  |. |   |. . 
alyGlfdGdrneelssllqrlmkdvlkeevqkdkneeeymkntll......vaqrklGeaGeklgsaallilirhdkvdPaksfsLevAsvGtlqavliR

NGQLEVLSLDHKPNNEaESKRIIQGGGWV-EFNRVNGNLALSRALGdYVFKHEnkkpedqIVTAFPDVETRKIMDDWEFIVLACDGIWDVMSNAEVLEF
||.   ||  .. ... | ||| .  . . | |..|| .. .| || |.| .        .|   | |.  .. .. |....  . .|.|.|  |. | 
ngkklrlsksyviekd.elkrikeakaiitednkingviestrllG.ytflfP.......vvlPkphvrevlLteqdellivGnkalWevlsideavea
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 54-189 1.6e-22 73.4 In-house 22-183 (292) alignment 
Range on Protein: 54-189
Range on HMM: 22-183/292.0
F-FAVYDGHG--GATVAQYAGKHLHKYVLKRPEYNDNIEQALQQGFLDIDYvMLRNKTCGDQMAGSTA-VVVLVKDN-KLYCANAGDSRAIACV-----N
|  ||.||||  |  |||.| ..| . .|.    . .. .|| .. |||    |.. |   .  ..|| |   |.|. .|. || |||||.        .
flaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllrildiaa.kldkltidaresattavvcarvrddralilanvGdsrallgrclggsd

GQLEVLSLDHKPNNEAESKRIIQGGGWVE-----------FNRV------NGNLALSRALGDY
 .|  || ||||..  | .|| . || ||             ||      .|.|||||||||.
yeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdf
subfamily_PPM1H_pd Subfamily PPM1H 88-160 1e-16 53.7 In-house 136-208 (404) alignment 
Range on Protein: 88-160
Range on HMM: 136-208/404.0
IEQALQQGFLDIDYVMLRNKTCGDQMAGSTAVVVLVKDNKLYCANAGDSRAIACVNGQLEVLSLDHKPNNEAE
.  || . ||..| .. |...   .. | ||.|.|| ..||| ||||||||| . ....  || |. |. | .
viGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRq
subfamily_PDP_pd Subfamily PDP 108-240 1.7e-20 66.5 In-house 146-307 (398) alignment 
Range on Protein: 108-240
Range on HMM: 146-307/398.0
TCGDQMAGSTAVVVLVKDNKLYCANAGDSRAIACVN---GQLEV--LSLDHKPNNEAESKRIIQGGG------WVEFNRVNGNLALSRALGDYVFKHEN-
..   ..|..|...|.....|. ||.||.||. .|.   |. |.  || |.  .||.| .|| .          .  .|. |.|. .|| ||. .| .. 
allvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwsee

--KKPEDQ---------------IVTAFPDVETRKIMDDWEFIVLACDGIWDVMSNAEVLEF
  ||.  .                .|| |.| ..|.  .  |.||| ||.||..|| || . 
lqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvsl
Subfamily Dicty-PPM1L-like 108-188 3.9e-08 25.5 In-house 210-294 (305) alignment 
Range on Protein: 108-188
Range on HMM: 210-294/305.0
TCGDQmaGSTAVVVLVKDNKLY-CANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGG---W--VEFNRVNGNLALSRALGD
  ||.  . . .|.  .|..|.  |.|.|.. . . .|  |||| ......  |  |. . ..   |   |  || ...|..|  ||
skGdk..nlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD
subfamily_PPM1G_pd Subfamily PPM1G 113-284 5e-64 210.0 In-house 295-470 (473) alignment 
Range on Protein: 113-284
Range on HMM: 295-470/473.0
MAGSTAVVVLVKDNKLYCANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGGWVE-FNRVNGNLALSRALGDYVFKHENK-KPEDQIVTAFPDVE
 .|.||||.|.|..||. |||||||.. . ||.   |||||||..| | .|| . || |.   |||| | |||||||...|.... ....|...|.||..
dsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDik

TRKIMDDWEFIVLACDGIWDVMSNAEVLEFCRTRIGMGM--FPEEICEELMNHCLAPDCQMGGLGGDNMTVVLVCL
....... ||.||||||||.||.  ||..| |...  |     .||.|||. .||||| .  | | |||||..|.|
vltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
subfamily_TAB1_pd Subfamily TAB1 114-234 1.3e-20 66.4 In-house 129-262 (333) alignment 
Range on Protein: 114-234
Range on HMM: 129-262/333.0
AGSTAVVVLVKDNKLYCANAGDSRAIACV---NGQLEVLSLDHKPNNEAESKRIIQGG---GWVEFNRVNGNLALSRALGDYVFKHENK------KPEDQ
 |.||||.|.  |||| ||.|||||...    . . . || ||. .|| | .|. . |     .. |.. |.    |..|||  |.  |      . ...
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakge

IVTAFPDVETR-KIMDDWEFIVLACDGIWDVMSN
 | | ||..   .| | . |.||  ||.   . .
PviaePdiqgaypiddityflvlmSdGvyktLee
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 115-284 1.3e-06 19.9 In-house 135-315 (317) alignment 
Range on Protein: 115-284
Range on HMM: 135-315/317.0
GSTAVVVLVKDN-KLYCANAGDSRAIACV---NG-------QLEVLSLDHKPNNEAESKRIIQGGGWVEFNRVNGNLAL-SRALGDYVFKHE----NKKP
|.|||| .| |. .. .|||||. |.  .   .|       ..| ||  |. . .|| .|. .  .       .| ||    || .|  .       |. 
GttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGhkll

EDQIVTAFPDVETRKIMDDWEFIVLAC-DGIWDVMSNAEVLEFCRTRIGMGMFPEEICEELMNHCLAPDCQmgglggDNMTVVLVCL
.   |.| |.| .| .  |  | |... ||| | ... .||.            | .|..  ...|. ..       |. | |...|
kraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcddaqdylldetsi......ddatavvlll
subfamily_PP2D1_pd Subfamily PP2D1 117-243 3.5e-20 65.2 In-house 179-304 (492) alignment 
Range on Protein: 117-243
Range on HMM: 179-304/492.0
TAVVVLVKDNKLYCANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGGWVE----FNRVNGNLALSRALGDYVFKHENKkpedQiVTAFPDVETR
.  | |..   || ||||. .|. | .|.  .|  .| |.|. | .|. . |. |       .||| |   | || |   . .|      |   | ... 
gsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkk....s.vipePkttsv

KIMDDWEFIVLACDGIWDVMSNAEVLEFCRT
|. .   |.|||  |.|.|.|. |||.  ..
kldeaaqflvlAsnGlWevlseeevlsLvkq
subfamily_PPM1H_pd Subfamily PPM1H 174-242 2.8e-07 22.6 In-house 275-348 (404) alignment 
Range on Protein: 174-242
Range on HMM: 275-348/404.0
NRVNGNLALSRALGDYVFKHEN-KKPEDQIVTAFPDVETRKIMD----DWEFIVLACDGIWDVMSNAEVLEFCR
.|. . .. .| |||.  |  . .     .....|.|... . .    . . ..|| ||.|||.|| ||.|  |
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivr
subfamily_PPM1D_pd Subfamily PPM1D 180-284 6.1e-12 38.2 In-house 201-307 (309) alignment 
Range on Protein: 180-284
Range on HMM: 201-307/309.0
LALSRALGDYvFKHeNKKPEDQIVTAFPDVETRKIMDDWE-FIVLACDGIWDVMSNAEVLEFCRTRIGMGMFP----EEICEELMNHCLAPdCQMGGLGG
||..|.|||  . . |.| .  .|   |||  |..  . | ||.|| ||.|.|.. ... .....   ....     ... . |... |    .   |  
LavaRslGDl.Wsy.naksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqr.wrskklra

DNMTVVLVCL
||..|..|.|
Dnvsvivvil
PPM_PTC7_SpoIIE_motif 220-284 3.6e-10 33.4 In-house 14-80 (81) alignment 
Range on Protein: 220-284
Range on HMM: 14-80/81.0
FIVLACDGIW-------DVMSNAEVLEFCRTRIGMGmfPEEICEELMNHCLApdcQMGGLGGDNMTVVLVCL
 ..|..||..       ..... |.|...... |..  ..|....|....|.   . .|   |..|......
vllLyTDGltEardsdgelfgkeellrladraegks..lqeladklvdevle...ngsgereDDitllvlrv
PPM_PTC7_motif 222-267 3e-15 49.5 In-house 1-47 (51) alignment 
Range on Protein: 222-267
Range on HMM: 1-47/51.0
VLACDGIWDVMSNAEVLEFCRTRIG-MGMFPEEICEELMNHCLAPDC
.||.||.|||.|. |. ...| ..  .|  |.|..|.|....||. .
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargs