Gene Ppm1 in Drosophila melanogaster

Synonym: CG12169, Dmel\CG12169, PP2C, dPPM1, Dmel_CG12169, Ppm1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1Z
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP133_AA protein Get Run
DmelP133_AA_2-286 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 3-286 1.7e-85 279.2 In-house 2-290 (295) alignment 
Range on Protein: 3-286
Range on HMM: 2-290/295.0
QTLSEPVTTKDTACCANASYRVGSSCMQGWRVDMEDAHTHILSLPD-DPQAAFFAVYDGHGGASVAKYAGKHLHKFITK-------RPEYRDNSIEVALK
..|| |.... . .  . ..|||....||.|  .|||....|.|.  ... ..|.|.||||| ..|..| ..|.... .         .. ...|| ||.
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

KAFLDFDREMLQNGSL--DEQTAGCTAIVVLIRERRLYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWVEFNRVNGNLALSRALGDFIY
||||  |.|.|. . |  . .. |.||.|.|||...||.||.|||||. . .|... |.|||||..  | .||...||.| ..||||.||..|||||| .
kaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl

KKNLLKTPEEQIVTAYPDVEVLDIT-EDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGMEPELICEELMNSCLSpdghtgNVGGDNMTVILVCL
|..|  ...|..|.|.||| ||..| || .|.|||.||.|||.|| |....|..... |...| ..|||.. .|.      . . ||.||..|.|
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla......rgsrDNiTvvvvrl
subfamily_PPM1G2_pd Subfamily PPM1G2 4-287 1.4e-138 453.7 In-house 1-287 (287) alignment 
Range on Protein: 4-287
Range on HMM: 1-287/287.0
TLSEPVTTKDTACCANASYRVGSSCMQGWRVDMEDAHTH---ILSLPDDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEYRDNSIEVALKKAFLDF
||||||..|..|.||||...||||.|||.|..|||||..   .|...||...|.|||.||||||.|||||||.|.|.|.|.........| .||.|||..
tlsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaflet

DREMLQNGSLDEQTAGCTAIVVLIRERRLYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWVEFNRVNGNLALSRALGDFIYKKNLLKTP
|.|.|.. .|....||.||.||||.|..||.||||||||.....|.|.|||.||||....|.|||.|.||.||.|||||||||||||||| .|||  |.|
DeellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkp

EEQIVTAYPDVEVLDITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGMEPELICEELMNSCLSPDGHTGNVGGDNMTVILVCLL
|||||||.|||.| ...|| ||..|||||||||..| ||...|..|...|.... |.|||...||.|| ....|| |||||..|.||
eeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvll
subfamily_PPM1G_pd Subfamily PPM1G 5-112 9.5e-31 100.3 In-house 2-107 (473) alignment 
Range on Protein: 5-112
Range on HMM: 2-107/473.0
LSEPVTTKDTACCANASYRVGSSCMQGWRVDMEDAHTHILSLpdDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEYRDNSIEVALKKAFLDFDREM
||.| . |..   .| . ..| | ||||||..||||. |. |  | . ..|||||||||. ||||  |.| ......  |... .| ||..|||..|...
lskpkvekesedesneelsygasamqGwrvsqEDahncitdl..dedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDekl

LQNGSLDE
 .. ||.|
kaeeslke
subfamily_PPM1A_pd Subfamily PPM1A 19-286 1.4e-87 286.6 In-house 9-280 (282) alignment 
Range on Protein: 19-286
Range on HMM: 9-280/282.0
NASYRVGSSCMQGWRVDMEDAHTHILSLPDDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEY--------RDNSIEVALKKAFLDFDREMLQNGSL
....|.| | ||||||.|||||| . ||.  .. .||||.|||.|..||||. |||.. |... |.         ..... ||...||..| .. .. . 
gnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstd

DE--QTAGCTAIVVLIRERRLYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWVEFNRVNGNLALSRALGDFIYKKNLLKTPEEQIVTAY
 .  . .|.||..||..|. |..||.|||||. |  | .. |. ||||...|| ||| . || |  .||||.||.||||||. ||..  |..||| |.| 
lktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsae

PDVEVLDITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGMEPELICEELMNSCLSPDghtgnvGGDNMTVILVCL
|.|......|. .|..|||||||||.|. ||...|.||.. . |.| ....|.. .|. .       .||..|..|..
pevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekg......srDNlsvlvvlf
PP2Cc_SM00332 19-284 1.6e-87 286.4 In-house 7-274 (274) alignment 
Range on Protein: 19-284
Range on HMM: 7-274/274.0
NASYRVGSSCMQGWRVDMEDAHTHILSLPDDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEYRDN----SIEVALKKAFLDFDREMLQNGSLDEQ-
|.... | |.|||||. |||||  ...|    ...||.|.|||||..|||.. |.|.... ..... ..    ..| |||||||..| |.|.. .  |. 
nlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskele

--TAGCTAIVVLIRERRLYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWVEFNRVNGNLALSRALGDFIYKKNLlkTPEEQIVTAYPDV
  ..|.||.|.|... .||.||.|||||. | .| ...|||||||.|..|.||| ..||.||..||||.||.|||.||. .|||    ..|...|| |||
nalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyitaepdv

EVLDITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGM--EPELICEELMNSCLSPdghtgNVGGDNMTVILV
.|...|.. ||..||.||.|||.|| ||...|.|... |   .|. ..|.|.. ...        . ||.||..|
kvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr.....ggseDniTvvvv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 21-284 1.5e-46 151.7 In-house 5-251 (255) alignment 
Range on Protein: 21-284
Range on HMM: 5-251/255.0
SYRVGSSCMQGWRVDMEDAHTHILSLPDDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEYRDNSIEVALKKAFLDFDREMLQNGsldeQTAGCTAI
 ..|| | | | |  |||  .   |  |...  ..|..||||| . ||.| ..|.| ...  .  . . . .||||. . .  . . .    .  |.||.
rfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserp....kfiGttaa

VVLIRERRLYCANAGDSRAIAC-ISGMVHALSVDHKPNDAKESKRIMASGGWVEFN----RVNGNLALSRALGDFIYkknllkTPeeqIVTAYPDVE-VL
.||| | . | || ||||.. |   |. . ||.||||.. .| ||| . || |  .    ||||.||.||||||         .|    |.. ||..  |
svliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfl......eP...fvvpdPdlsqsl

DITEDLEFVLLACDGIWDVMSNFEVCQFVHKrIrdgMEPELICEELMNSCLSpDGHTgnvggDNMTVILV
.|... .|..||||||||..|. | .. | . |    .||  .|.| .   |  | |     ||..||..
eiskkdkflilacdGiwdlisdeeaveivag.i...sdpekaaeklrdlays.sGst.....dnisvivi
0049733 PP2C-like 22-286 2.6e-58 190.0 In-house 3-233 (235) alignment 
Range on Protein: 22-286
Range on HMM: 3-233/235.0
YRVGSSCMQGW-RVDMEDAHTHilslpddpQAAFFAVYDGHGGASVAKYAGKHLHKFITKR-PEYRDNSIEVALKKAFLDFDREMLQNGSL--DEQTAGC
..|| ....|. |  .|||.          . ..|||.|||||. ....| ..|.... .   |.   ..| ||.||||  ....|. .    . .. |.
lsvgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgt

TAIVVLIRERRLYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWVefnRVNGNLALSRALGDFIYKknllktpeeqivtayPDVEVLDIT
||.|.|.....||.||.|||||. . .| .. |..||.|..  | .||.. ||.|   ||.| |||.|||||. .|               ||| ||...
TavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvlele

EDLeFVLLACDGIWDVMSNFEVCQFVHKrirdgMEPELICEELMNSCLSpdghtgNVGGDNMTVILVCL
..  |.|||.||.|||.|. |.......     ...| ..|.|.. .|.      . | ||.||..|.|
pgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala......rggrDNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 22-286 2.2e-57 187.2 In-house 4-262 (265) alignment 
Range on Protein: 22-286
Range on HMM: 4-262/265.0
YRVGSSCMQGWRVDMEDAHTHILS------LPDDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEYRDNSIeVALKKAFLDFDREMLQNGSLDEQTA
|.| . .... |  ||| |  . .      | |... |||||.|||||   |||| .|||... ....  ...   |||.||   |...||    .. ..
yevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqkaereklks

GCTAIVVLIRERRLYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWV---EFNRVNGNLALSRALGDFIYKknllktpeeQIVTAYPDVE
|.||.||||....|| |  |||.|. .  | .  |   |||.. .| ||| . || |   .  ||||.|..|||.||  .|         . |.. .|| 
GstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsgeadva

VLDITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGM-EPELICEELMNSCLSPDGHtgnvggDNMTVILVCL
 ...... |...|||||.|||. . ||.. |.. ..||  . . . ..|...  . . .      ||.||..| |
eveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagss......Dnitvvvvfl
PPM_PTC7 23-268 3.2e-81 265.6 In-house 2-254 (259) alignment 
Range on Protein: 23-268
Range on HMM: 2-254/259.0
RVGSSCMQGWRVDMEDAHTHILSLP---DDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEYRDN-SIEVALKKAFLD--FDREMLQNGSL-DEQTA
..|.|..||.|. |||||..   |    ..   |||||.|||||  .||||..||.... .|.. ..    | ||.|.||   .| |. .      ..| 
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepsts

GCTAIVVLIRERRLYCANAGDSRAIACISGMVH-ALSVDHKPNDAKESKRIMASGGWVE---FNRVNGNLALSRALGDFIYKKNLLktpEEQIVTAYPDV
|.||.|.||.. .||.||.|||||. |.|| .. .|..||||.. .| .|| ..||.|.   ..||||.||.|||.||| .|..     ||| |.| ||.
GstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePdi

EVLDITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGmEPELICEELMNSCLSPD
.. .|.|. ||..||.||.|||.|. |....|.... .. .|. ..|.|.. .....
sstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiarg
PP2C Protein phosphatase 2C 23-267 3.5e-81 265.5 Pfam-A 2-249 (255) alignment 
Range on Protein: 23-267
Range on HMM: 2-249/255.0
RVGSSCMQGWRVDMEDAHTHILSL---PDDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEYRDN-SIEVALKKAFLD-FDREMLQNGSL-DEQTAG
.||.|..||.|  |||||... .|    .. . |||||.|||||  .||||..||.... .... ..    | ||.|.||  .| |. ..     ... |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksG

CTAIVVLIRERRLYCANAGDSRAIACISGMVH-ALSVDHKPNDAKESKRIMASGGWVE-FNRVNGNLALSRALGDFIYKKNLlktpeEQIVTAYPDVEVL
.||.|.|||. .||.||.|||||. |...  . .|..||||.| .| .|| ..||.|. ..||||.||.||||||| .|..      ||.|.| |||.. 
stavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsv

DITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGMEPELICEELMNSCLSP
..||. ||..||.||.|||.|. |....|.... .. .|. ..|||.. ....
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiar
PP2C Protein phosphatase 2C 23-267 3.5e-81 265.5 In-house 2-249 (255) alignment 
Range on Protein: 23-267
Range on HMM: 2-249/255.0
RVGSSCMQGWRVDMEDAHTHILSL---PDDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEYRDN-SIEVALKKAFLD-FDREMLQNGSL-DEQTAG
.||.|..||.|  |||||... .|    .. . |||||.|||||  .||||..||.... .... ..    | ||.|.||  .| |. ..     ... |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksG

CTAIVVLIRERRLYCANAGDSRAIACISGMVH-ALSVDHKPNDAKESKRIMASGGWVE-FNRVNGNLALSRALGDFIYKKNLlktpeEQIVTAYPDVEVL
.||.|.|||. .||.||.|||||. |...  . .|..||||.| .| .|| ..||.|. ..||||.||.||||||| .|..      ||.|.| |||.. 
stavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsv

DITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGMEPELICEELMNSCLSP
..||. ||..||.||.|||.|. |....|.... .. .|. ..|||.. ....
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiar
PPM_PTC7_SpoIIE 23-261 8.6e-46 149.6 In-house 2-218 (230) alignment 
Range on Protein: 23-261
Range on HMM: 2-218/230.0
RVGSSCMQGWRVDMEDAHTHILSL---PDDPQAAFFAVYDGHGGASvaKYAGKHLHKFITKRPeYRDNS-IEVALKKAFLDFDREMLQNgsldEQTAGCT
..|.|..||.|  |||||..   .   ...  |......||||| .  ..| ..|.... ..  ... .  | .|....| .....  .    ... |.|
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede....psssgaT

AIVVLIRERR--LYCANAGDSRAIACIS-GMvhalsvdhkpndakESKRImASGGWVE----FNRVNGNLALSRALGDFIYKKnllktpEEQIVTAYPDv
|.|.||.  .  ||.||||||... . . |               | .|| ..||...    ..||.|.||.|.| ||....       ....|.| || 
avvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaepd.

EVLDITED-LEFVLLACDGIWDVMSNFEVCQFVHKRIRDGmepelICEELM
 . .....  ||. ||.||.|||.|. |....| ... .      ..|.|.
tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaegll
subfamily_PPM1D_pd Subfamily PPM1D 23-286 3.7e-38 124.3 In-house 3-307 (309) alignment 
Range on Protein: 23-286
Range on HMM: 3-307/309.0
RVGSSCMQGWRVDMEDAHTHILSLPDDP---QAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEYR---DNSIEVALKKAFLDFDREMLQN-------GS
.| |.. || |  |||  .  |.  .     . ||.||.|||||   ||.| .|| ..|.|. ..    ....  |...|||.  ..| ..        |
svtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktks

LDEQTAGCTAIVVLIRERRLYCANAGDSRAIACISGM------VHALSVDHKPNDAKESKRIMASGGWVEFN---------R----VNGN--------LA
 .  ||| || ||.||...|| |. |||...  ..         . | .||||.. .| .||  .|| |  .         |     ||.        ||
gllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLa

LSRALGDFIYKKnllKTPEEQIVTAYPDVEVLDITEDLE-FVLLACDGIWDVMSNFEVCQFVHKRIRDGME----PELICEELMNSCLSPDgHTGNVGGD
..|.|||.   .   .. .| .|   ||| |  .. . | |..|| ||.|.|..  .. ..|.|    ..      . . . |... |.   .. ..  |
vaRslGDlWsyn...aksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrw.rskklraD

NMTVILVCL
|..||.|.|
nvsvivvil
subfamily_PPM1K_pd Subfamily PPM1K 24-246 3.4e-41 134.1 In-house 6-228 (263) alignment 
Range on Protein: 24-246
Range on HMM: 6-228/263.0
VGSSCMQGWRVDMEDAhTHILSLpdDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPeYRDNSIEVALKKAFLDFDREMLQNGSLD-----EQTAGCT
||   ..| | . ||   ... |  ||.  ..||.|||.|.. |... ..|.| ...    ... .|. ||.||.. |... .   .      ....| |
vGkdsliGkraenedr.iklkel..dpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaellssGtt

AIVVLIRE-RRLYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWVEFN-----RVNGNLALSRALGDFIYKKnllktpeeQIVTAYPDVE
| |.|.|.   |  |. |||||| |  |  . |. ||.|.  .| .|| |.|| ||.|     .||| ||..|.|||.  |.          | | |.  
atvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkr........yGviatPetk

VLDI-TEDLEFVLLACDGIWDVMSNFEVCQFVHKR
 |..  ..  |..|  ||| .|....|.|..|.. 
slkvdhaadsflvlitdgisfvvnsqelcdlvrlc
subfamily_PPM1L_pd Subfamily PPM1L 25-261 6.3e-46 149.8 In-house 8-247 (269) alignment 
Range on Protein: 25-261
Range on HMM: 8-247/269.0
GSSCMQGWRVDMEDAHTHILSLPDDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRP-E---YRDNSI----EVALKKAFLDFDREMLQNGSLDEQTAG
   ...| |  |||  .    . .. .  ||||.|||||   |..| . | | | ..  |    ..|..    .  |..  |  |...|..    |..||
avysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaG

CTAIVVLIRERRLYCANAGDSRAIAC-ISGMVHALSVDHKPNDAKESKRIMASGGWVEFN---RVNGNLALSRALGDFIYKknllktpEEQIVTAYPDVE
.||.. |..|. |  || |||| . .  .|.   || ||||.. || |||  .||.. |.   ||.| || ||||||.  |       ....| | ||. 
ttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.......dknlviadpdil

VLDITE-DLEFVLLACDGIWDVMSNFEVCQFVHKRIRdgmEPELICEELM
 .|. . . ||..||.||.|| .|| | ..|...|.    ||..    |.
tfdlddhkpeflilasdGlwdtfsneeavrfikerlk...epdfGakslv
subfamily_ILKAP_pd Subfamily ILKAP 26-255 2.6e-41 134.7 In-house 9-251 (293) alignment 
Range on Protein: 26-255
Range on HMM: 9-251/293.0
SSCMQGWRVDMEDAHTHILSLPDD--------PQAAFFAVYDGHGGASVAKYAGKHLHKFITKRP-----EYRDNSIEVALKKAFLDFDREMLQNGSLDE
 .. .| | .|.|||. . .| ..         .....||.|||.|   ...| ..||| | ..        ....|  .| ..|   |.|.|.  | ..
yaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskak

Q--TAGCTAIVVLIRERRLYCANAGDSRAIACISGM------VHALSVDHKPNDAKESKRIMASGGWVEFNRVNGNLALSRALGDFIYKKNllktpeeqI
     |.||.|||. .  || || |||.|. .          . .|..||.| . .| |||  .|| |. .||.| |  ||..||  .|.          
PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrl........G

VTAYPDVEVLDITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGMEPEL
|.. |||. ...||.  ||.|||||.|.|.|. || .|. | . |  . . 
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrk
Subfamily Dicty-PPM1L-like 28-78 2.4e-06 19.6 In-house 13-63 (305) alignment 
Range on Protein: 28-78
Range on HMM: 13-63/305.0
CMQGWRVDMEDAHTHILSLPDDPQAAFFAVYDGHGGASVAKYAGKHLHKFI
  .. |   || .   .|| .. .  .| |.|||.|   |.|. |.| . .
vsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveiv
subfamily_PP2D1_pd Subfamily PP2D1 31-92 1.9e-11 36.4 In-house 12-73 (492) alignment 
Range on Protein: 31-92
Range on HMM: 12-73/492.0
GWRVDMEDAHTHILSLPDDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEYRDNSIEVA
 |. .|||..|      .|.. .||..|||. ||. |. | |.||. .... |  |......
rWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervslt
subfamily_KAPP-like_pd Subfamily KAPP-like 33-286 1.2e-25 83.0 In-house 9-266 (266) alignment 
Range on Protein: 33-286
Range on HMM: 9-266/266.0
RVDMEDAHTHILSLPDDPQ------AAFFAVYDGHGGASVAKYAGKHLHKFITKRPEY--RDNSIE--VALKKAFLDFDREmLQNGSLDEQTAGCTAIVV
 . ||| .  |  | .. .       |.|||.||| |  .|. | | . | . |  .   .|.  .     .| ...  .| ...   | .  |.|| ..
stemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafke.vdaklkdfeyeGatatla

LIR----ERRLYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWVEFN--RVNGnLALSRALGDFIY-KKNLLKTPEEQIVTAYpdvevlD
|.      | | .|| ||| |. .       || ||| .| .| .||   |  .  |  |.|| ||.|||||| .  ..|.  . |  .   .       
lvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnri......l

ITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGMepeliCEELMNSCLSPDGHTGNVGGDNMTVILVCL
.|   .|...| ||.|||.|  .  . |.    ..       |. | |.|           ||..||.| |
ltpfdkflivasdGlwdvisGkdaiekvkslydqqa.....tedkmasslletaiqsikakdnvsvivvkl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 33-286 3.2e-22 71.7 In-house 8-276 (276) alignment 
Range on Protein: 33-286
Range on HMM: 8-276/276.0
RVDMEDAHTHILSLPDDPQ------AAFFAVYDGHGGASVAKYAGKHLHKFITKRPEY-------RDNSI--EVALKKAFLDFDREMlQNGSLDEQTAGC
 . ||| .  |  | |. .       |.|||.||| |  .|. | | . | . |  .        .|.        .| .||  .|. ..   | .  |.
stemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkev.daklkdfeyeGa

TAIVVLIR----------ERRLYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWVEFN--RVNGnLALSRALGDFIYK-KNLLKTPEEQI
|| ..|.           .| | .|| ||| |. .       || ||| .| .| .||   |  .  |  |.|| ||.|||||| . | .|.  . |  .
tatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyv

VTAYpdvevlDITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGMepeliCEELMNSCLSPDGHTGNVGGDNMTVILVCL
   .       .|   .|...| ||.|||.|  .  . |.    ..       |. | |.|           ||..||.| |
snri......lltpfdkflivasdGlwdvisGkdaiekvkslydqqa.....tedkmasslletaiqsikakdnvsvivvkl
PP2C_SIG_SM00331 47-284 1.8e-14 46.8 In-house 27-215 (217) alignment 
Range on Protein: 47-284
Range on HMM: 27-215/217.0
PDDpqAAFFAVYDGHG----GASVAKYAGKHLHKFITKRpeyrdNSIEVALKKAFLDFDREmlqngsLDEQTAGCTAIVVLI--RERRLYCANAGDSRAI
...    ...| ||.|    .| ... . . |.......     .... |||..   ...|       .|.  ..|... |.  ....|. ||||||| .
neg..rlllvvaDgmGkGlaAaaassqlrtalrellseg.....eelsqalkrlnraiyee......keekgmfaTlllalydfssgklsyanaGdsrpy

ACI-SGMVHALSVdhkpndakeskrimasggwvefnrvngnlalsralgdfI-----------YkknllktpeeqivtayPDVEVLDITEdLEFVLLACD
    ...|. |.                                       .                            .|.. |.. .  ...||. |
llrdgklveilkd......................................vegaplGlepevs................vdirelelek.gdllllytD

GIWDVM-----SNFEVCQFVHKRIrdGMEPELICE----ELMNSCLSPDGhtgnvgGDNMTVILV
|.....      ........ .    ..|.. . .    ||...   . |       |..||..|
Gltearsekgfaeerleeiledlv..dseaqelaqkiveellelakgsng......eDdiTvvvv
PP2C_2 Protein phosphatase 2C 48-241 2.1e-09 30.0 Pfam-A 20-188 (212) alignment 
Range on Protein: 48-241
Range on HMM: 20-188/212.0
DDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEYRDNSIEVA-LKKAFLDFDREML---------QNGSLDEQTAGCTAIVVLIRERRLYCANAGDS
.. .. ..|| ||.| |. .. . . . . .... |   .. . .  .... .. .|.|         . .  . .  ..| ....|......... ||.
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDg

RAIA-CISGMVHALSVDHKPNDAKESKRIMASGGWVEFnrvngnlalsralgdfiykknllktpeeqivtaypDVEVLDiTEDLEFVLLACDGIWDVMSN
....   .| |..|. ...   | |  ..  .  . |.                                   ... |. .|... .||  ||..| ...
aivvrdrdgevqllgepdsgeyanettfltsedaeeel...................................rirrlk.lepgdalllmTDGvsdslrk

FEVCQ
 |  .
eepfr
PP2C_2 Protein phosphatase 2C 48-241 2.1e-09 30.0 In-house 20-188 (212) alignment 
Range on Protein: 48-241
Range on HMM: 20-188/212.0
DDPQAAFFAVYDGHGGASVAKYAGKHLHKFITKRPEYRDNSIEVA-LKKAFLDFDREML---------QNGSLDEQTAGCTAIVVLIRERRLYCANAGDS
.. .. ..|| ||.| |. .. . . . . .... |   .. . .  .... .. .|.|         . .  . .  ..| ....|......... ||.
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDg

RAIA-CISGMVHALSVDHKPNDAKESKRIMASGGWVEFnrvngnlalsralgdfiykknllktpeeqivtaypDVEVLDiTEDLEFVLLACDGIWDVMSN
....   .| |..|. ...   | |  ..  .  . |.                                   ... |. .|... .||  ||..| ...
aivvrdrdgevqllgepdsgeyanettfltsedaeeel...................................rirrlk.lepgdalllmTDGvsdslrk

FEVCQ
 |  .
eepfr
subfamily_PHLPP_pd Subfamily PHLPP 51-245 2.1e-08 26.4 In-house 26-214 (246) alignment 
Range on Protein: 51-245
Range on HMM: 26-214/246.0
QAAFFAVYDGHGGASVAKYAGKHLHKFITKRpEYRDNSIEVALKKAFLDFDREMLQNGsldeQTAGCTAIVVLIRER--------RLYCANAGDSRAIAC
. | . ..||.    ...   . ......     .|.. |. .|. .|   |.. ..|    .  | .|...|||.         .|  |. |   |. .
vealyGlfdGdrneelssllqrlmkdvlkee.vqkdkneeeymkntllvaqrklGeaG....eklgsaallilirhdkvdPaksfsLevAsvGtlqavli

ISGMVHALSVDHKPNDAkESKRIMASGGWV-EFNRVNGNLALSRALGDFIYKKNLLKTpeeqivtayPDVEVLDITEDLEFVLLACDGIWDVMSNFEVCQ
  |    ||  .. ..  | |||    . . | |..|| .. .| || .     .| .         | |. . .||. |....  . .|.|.|  |. .
Rngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytflfPvvlPk.........phvrevlLteqdellivGnkalWevlsideave

FVHK
 |.|
avrk
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 54-204 2e-20 66.5 In-house 22-198 (292) alignment 
Range on Protein: 54-204
Range on HMM: 22-198/292.0
F-FAVYDGHG--GASVAKYAGKHLHKFITKRPEYRdNSIEVALKKAFLDFDREmLQNGSLDEQTAGCTAIV-VLIRE-RRLYCANAGDSRAIA--CISGM
|  ||.||||  |  ||..| ..| . ...        .  || .  ||   . |..  .|..  . ||.|   .|. |.|. || |||||.   |. | 
flaavldGhGvnGdkvaqlaedtlevelleltrql.qelsealllrildiaak.ldkltidaresattavvcarvrddralilanvGdsrallgrclggs

---VHALSVDHKPNDAKESKRIMASGGWVE-----------FNRV------NGNLALSRALGDFI-YKKNLLKTPEEQI
   .  || ||||.|  | .||...|| ||             ||      .|.||||||||||  ..  ..  || ||
dyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePelqi
subfamily_PDP_pd Subfamily PDP 87-252 6.3e-21 67.9 In-house 113-317 (398) alignment 
Range on Protein: 87-252
Range on HMM: 113-317/398.0
NSIEVALKKAFLDFDREMLQNGS-----------LDEQTAGCTAIVVLIRERRLYCANAGDSRAIACIS---GM--VHALSVDHKPNDAKESKRIMASG-
.... |||||||..|... ..             |.  ..| .|...||... |. ||.||.||. . .   |.  . .|| |.  . ..| .|| .   
ekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHP

-----GWVEFNRVNGNLALSRALGDFIYKKNL------LKT---PEEQ--------IVTAYPDVEVLDITEDLEFVLLACDGIWDVMSNFEVCQFVHKRI
       .  .|. |.|. .|| ||. || .       |..   .  .         .|| |.|    ..|.  |..|| ||.||..|| || . |.. .
geesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehl

RDGME
 . .|
akkke
subfamily_PPM1H_pd Subfamily PPM1H 88-161 1e-17 57.0 In-house 135-208 (404) alignment 
Range on Protein: 88-161
Range on HMM: 135-208/404.0
SIEVALKKAFLDFDREMLQNGSLDEQTAGCTAIVVLIRERRLYCANAGDSRAIACISGMVHALSVDHKPNDAKE
 .  || .|||. |  . .. .  ... ||||.|.|. . .|| ||||||||| . .. ...|| |. |.  ..
LviGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRq
subfamily_PPM1G_pd Subfamily PPM1G 114-286 3.4e-64 210.6 In-house 295-470 (473) alignment 
Range on Protein: 114-286
Range on HMM: 295-470/473.0
TAGCTAIVVLIRERRLYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWVE-FNRVNGNLALSRALGDFIYKKNLLKTPEEQIVTAYPDVE
 .|.||.|.|..|..|. |||||||.. . .|    ||.||||.| .| .|| . || |.   |||| | |||||||..||||    ..||...|.||..
dsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDik

VLDITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGMEP--ELICEELMNSCLSPDGHTGNVGGDNMTVILVCL
|| .||. ||. |||||||.||.  || .||......| |   . |.|||.  ||.|| .    | ||||||.|.|
vltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
subfamily_TAB1_pd Subfamily TAB1 114-234 9.5e-18 57.1 In-house 128-260 (333) alignment 
Range on Protein: 114-234
Range on HMM: 128-260/333.0
TAGCTAIVVLIRERRLYCANAGDSRAIACI---SGMVHALSVDHKPNDAKESKRIMASG---GWVEFNRVNGNLALSRALGDFIYKK-----NLLKTPEE
. | ||.|.||    || ||.|||||...    |  |. |||||. .  .| .|.   |     .. |.. |.    |..||.  ||     ..|.. ..
sgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakg

QIVTAYPDVEVL-DITEDLEFVLLACDGIWDVM
. | | ||..   .|..   |..|  ||.   .
ePviaePdiqgaypiddityflvlmSdGvyktL
subfamily_PP2D1_pd Subfamily PP2D1 122-248 6.2e-18 57.7 In-house 183-307 (492) alignment 
Range on Protein: 122-248
Range on HMM: 183-307/492.0
VLIRERRLYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWVE----FNRVNGNLALSRALGDFiYKKNlLKtpeeQIVTAYPDVEVLDIT
 |.    || ||||. .|. |  |    |  .| |.. || .|.  .|. |       .||| |   | || .    . ||    . |   | ..   ..
hleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny.Gdpk.Lk....ksvipePkttsvkld

EDLEFVLLACDGIWDVMSNFEVCQFVHKRIR
|   |..||  |.|.|.|. || . |.. ..
eaaqflvlAsnGlWevlseeevlsLvkqtla
Subfamily Dicty-PPM1L-like 130-189 1.7e-07 23.4 In-house 230-294 (305) alignment 
Range on Protein: 130-189
Range on HMM: 230-294/305.0
YCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGG---W--VEFNRVNGNLALSRALGD
  |.|.|.. . .  |. ..|| ...... ||  |.  |..   |   |  || ...|..|  ||
vvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD
subfamily_PPM1H_pd Subfamily PPM1H 175-247 9.3e-08 24.2 In-house 275-351 (404) alignment 
Range on Protein: 175-247
Range on HMM: 275-351/404.0
NRVNGNLALSRALGDFIYKKNLLKTPEEQIVTAYPDVEVLDITE----DLEFVLLACDGIWDVMSNFEVCQFVHKRI
.|. . .. .| |||   |    .     .... |.|.|||.|.    . . ..|| ||.|||.|| || . |.. .
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevl
PPM_PTC7_SpoIIE_motif 222-286 1.5e-09 31.4 In-house 14-80 (81) alignment 
Range on Protein: 222-286
Range on HMM: 14-80/81.0
FVLLACDGIW-------DVMSNFEVCQFVHKRirDGMEPELICEELMNSCLSpdgHTGNVGGDNMTVILVCL
 .||..||..       ..... |........  .|.........|....|.   ....   |..|......
vllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevle...ngsgereDDitllvlrv
PPM_PTC7_motif 224-267 1.3e-14 47.4 In-house 1-45 (51) alignment 
Range on Protein: 224-267
Range on HMM: 1-45/51.0
LLACDGIWDVMSNFEVCQFVHKRIR-DGMEPELICEELMNSCLSP
.||.||.|||.|. |....|....  .| .|. ..|.|.. .|..
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealar