Gene CG7115 in Drosophila melanogaster

Synonym: BcDNA:LD21794, Dmel\CG7115, PP2C, Dmel_CG7115, CG7115

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1L
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP135_AA protein Get Run
DmelP135_AA_103-484 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 104-484 1.6e-69 226.9 In-house 16-292 (295) alignment 
Range on Protein: 104-484
Range on HMM: 16-292/295.0
WEEMKQQSSAFAVLGRRPRMEDRFIIEENINN-NTGISFFAVFDGHGGEFAADFAKDVLVKNIYNKIIEMSKLLKTEgnsgdydkspylarkqsrkdank
.. .. ..... . |||. .||....  |... ......|.|||||||  ||..|.. ||..... . ..  || ..                       
slllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltls.......................

enteptagvmrkdslrkahsttadcsaikqktteasiadiytvqlnsamrasgnlgaakdsflnnnnngqngaanapppnyeakcyiehgRINFGKLITD
                                                                                            .. . ...
..........................................................................................ledieealrk

EIMSADYKLVEQAKR--ATNIAGTTALIAIVQGSKLIVANVGDSRGVMYdWRGIAIPLSFDHKPQQVRERKRIHDAGGFIAFrgvWRVAGVLATSRALGD
 ...||..|.|.| .       ||||..|...|.||.|||||||| |..  .| ...|..|||| .  ||.|| .|||.. .   .|| |||| .|||||
aflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravll.rngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGd

YPLK-------DKNLVIATPDILTFELNDHKPHFLILASDGLWDTFSNEEACTFALEH---LKEPDFGAKSLAMESYKRGSVDNITVLVIVFKN
..||        . ||.|.||. ..||. .. .||.||||||||..||||..... ..    ....  |. |. ....||| |||||.|. ...
fdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng
subfamily_PPM1G2_pd Subfamily PPM1G2 104-168 4.8e-10 31.8 In-house 14-81 (287) alignment 
Range on Protein: 104-168
Range on HMM: 14-81/287.0
WEEMKQQSSAFAVLGRRPRMEDRFIIEENIN---NNTGISFFAVFDGHGGEFAADFAKDVLVKNIYNK
 .... . .. |. | |  |||  |.|...    ... ...|||||||||. .| .|   |.| | .|
canaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakk
subfamily_PPM1L_pd Subfamily PPM1L 105-485 1.7e-158 518.9 In-house 1-269 (269) alignment 
Range on Protein: 105-485
Range on HMM: 1-269/269.0
EEMKQQSSAFAVLGRRPRMEDRFIIEENINNNTGISFFAVFDGHGGEFAADFAKDVLVKNIYNKIIEMskllktegnsgdydkspylarkqsrkDANKEN
||.|||.....||||||||||||.|||.|.|.||.|||||||||||||||.||||||||.|.||.||.                          ||.|||
eekkqqvavysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkliel..........................dadken

TEPtagvmrkdslrkahsttadcsaikqktteasiadiytvqlnsamrasgnlgaakdsflnnnnngqngaanapppnyeakcyiehgrINFGKLITDEI
|||                                                                                      |||.||.||||
tep......................................................................................infsklltdei

MSADYKLVEQAKRATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDWRGIAIPLSFDHKPQQVRERKRIHDAGGFIAFRGVWRVAGVLATSRALGDYPLK
.|.|.||.|.||||..|||||||||.||.|.||||||||||||.||.||.|||||||||||||.|||||..|||||||||||||||||||||||||||||
lsvdekllekakraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk

DKNLVIATPDILTFELNDHKPHFLILASDGLWDTFSNEEACTFALEHLKEPDFGAKSLAMESYKRGSVDNITVLVIVFKND
|||||||.||||||.|.||||.||||||||||||||||||..|..|.|||||||||||..||.||||||||||||...|||
dknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvklknd
subfamily_PPM1E_pd Subfamily PPM1E 109-168 5.4e-12 38.4 In-house 4-69 (265) alignment 
Range on Protein: 109-168
Range on HMM: 4-69/265.0
QQSSAFAVLGRRPRMEDRFIIEENINNNTG------ISFFAVFDGHGGEFAADFAKDVLVKNIYNK
 . |..|| ..| .||||... |..|.  .      ..||||||||||  ||..|.  | ... ..
yevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrq
0049733 PP2C-like 110-483 5.4e-54 175.9 In-house 4-234 (235) alignment 
Range on Protein: 110-483
Range on HMM: 4-234/235.0
QSSAFAVLGR-RPRMEDRFIIeeninnntGISFFAVFDGHGGEFAADFAKDVLVKNIYNKIIEmskL---Lktegnsgdydkspylarkqsrkdankent
. .|. . || |. .||....        |...|||.|||||  |...| . ||..... . |   |                                 
svgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle...lllld.............................

eptagvmrkdslrkahsttadcsaikqktteasiadiytvqlnsamrasgnlgaakdsflnnnnngqngaanapppnyeakcyiehgrinFGKLITDEIM
                                                                                            ..... ..
..........................................................................................leealrkafl

SADYKLVEQAKR--ATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDwRGIAIPLSFDHKPQQVRERKRIHDAGGFIafrgvwRVAGVLATSRALGDYPL
 |.  |.|.|..       ||||..|...|.||.|||||||| .... .| ...|..||.| .  ||.||..|||..      || |.|| .|||||..|
aaneallelalaspelagmgtTavvalldggklyvanvGDsrayllr.dgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlll

KdknlviatPDILTFELNDHKphFLILASDGLWDTFSNEEACTFALEhlKEPDFGAKSLAMESYKRGSVDNITVLVIVFK
|        ||. ..||...   ||.|||||||| .|.||.. .  .  ....  |. |. . ..||. |||||.|. ..
k........pdvtvlelepgd..flllasDGlwdvlsdeeivdllrs..ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_PPM1G_pd Subfamily PPM1G 110-165 3.2e-07 22.7 In-house 20-73 (473) alignment 
Range on Protein: 110-165
Range on HMM: 20-73/473.0
QSSAFAVLGRRPRMEDRFIIEENINNNTgiSFFAVFDGHGGEFAADFAKDVLVKNI
. .| |  | |  .||      .....|  |.|||.|||||.  | .  . | . .
sygasamqGwrvsqEDahncitdldedt..slfavyDGHGGkevakyvakklpdll
subfamily_PPM1D_pd Subfamily PPM1D 112-168 6.1e-12 38.2 In-house 5-64 (309) alignment 
Range on Protein: 112-168
Range on HMM: 5-64/309.0
SAFAVLGRRPRMEDRFIIEENINNN---TGISFFAVFDGHGGEFAADFAKDVLVKNIYNK
...|  | |. |||.. |  . ...    . .|.||||||||. || ||.. |...| ..
tseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkq
subfamily_PPM1A_pd Subfamily PPM1A 114-483 2.1e-61 200.7 In-house 17-281 (282) alignment 
Range on Protein: 114-483
Range on HMM: 17-281/282.0
FAVLGRRPRMEDRFIIEENINNNTGISFFAVFDGHGGEFAADFAKDVLVKNIYNkiiemskllktegnsgdydkspylA----RkqsrKDANKENTEPTA
 .. |.| .|||....  .... .. |||||||||.|. .|...|. |..|| .                                  . ....... . 
ssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenile........................eeelke....aaleasekdevk

GVMRKDSLRKaHSTTADCSAIKQKTtEASiadiytvqlnsamrasgnlgaakdsflnnnnngqngaanapppnyeakcyiehgrinfgklitdeimsady
 ..|.  |.  .... . |. .... . |                                                                       
ealrqgfLal.deairelstdlkta.dks.......................................................................

klveqakratniaGTTALIAIVQGSKLIVANVGDSRGVMYDwRGIAIPLSFDHKPQQVRERKRIHDAGGFIAfrgVWRVAGVLATSRALGDYPLKD----
             |.||. ..|. ..||.||.||||.|..   | |. |. ||||.. .|.|||..|||..    | || | || ||||||| .|.    
.............GsTavtvlvsekhliianlGDsRavlcr.ngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeeek

---KNLVIATPDILTFELNDHKPhFLILASDGLWDTFSNEEACTFALEHLK---EPDFGAKSLAMESYKRGSVDNITVLVIVFK
   . ||.| |.. ..| ....  ||.||.||.||. |.||.. .. ..|.   |.   ||.|  .....|| ||..|||..|.
kaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
PP2Cc_SM00332 115-480 5.2e-62 202.7 In-house 16-274 (274) alignment 
Range on Protein: 115-480
Range on HMM: 16-274/274.0
AVLGRRPRMEDRFIIEENINNNTGISFFAVFDGHGGEFAADFAKDVLVKNIYNKIIEMSKLLktegnsgdydkspylarkqsrkdankenteptagvmrk
.  |.| .|||....  . ..... .||.|||||||. .|.|... |.... ... . .. |                                      
smqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel......................................

dslrkahsttadcsaikqktteasiadiytvqlnsamrasgnlgaakdsflnnnnngqngaanapppnyeakcyiehgRINFGKLITDEIMSADYKLVEQ
                                                                                .  ... . . |.| ...|.
..............................................................................eddveealkkaflstdeeilee

AKRATN---IAGTTALIAIVQGSKLIVANVGDSRGVMYDWRGiAIPLSFDHKPQQVRERKRIHDAGGFIAFRgvwRVAGVLATSRALGDYPLK-----DK
...  .    .|.||..|.... .|.|||||||| |..  .  |..|| ||||.. .|||||..|||.....   || |.|| |||.||. ||      .
eqskelenalsGstavvallkkedlyvanvGDSravlcrngk.avqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklke

NLVIATPDILTFELnDHKPHFLILASDGLWDTFSNEEACTFALEHL-----KEPDFGAKSLAMESYKR-GSVDNITVLVI
  ..|.||. . .| . .  ||||||||||| .||.|.. .  ..|     ..|.  |. |..| ..| || |||||.|.
pyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 115-169 1.6e-12 40.2 In-house 12-65 (255) alignment 
Range on Protein: 115-169
Range on HMM: 12-65/255.0
AVLGRRPRMEDRFIIEENINNNTGISFFAVFDGHGGEFAADFAKDVLVKnIYNKI
 ..|||| |||...|  . .....  ..|.||||||. ||.|| . | | | ...
dmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelyk.ilael
subfamily_PPM1K_pd Subfamily PPM1K 116-227 6.6e-10 31.5 In-house 11-121 (263) alignment 
Range on Protein: 116-227
Range on HMM: 11-121/263.0
VLGRRPRMEDRFIIEENINNntgISFFAVFDGHGGEFAADFAKDVL---VKNIYNKIIEMSKLLKTEGNSGDYDKSPYLARKQSRKdaNKENTEPTAGVM
 .|.|   |||. ..|  ..   . ..||||||.|  ||||. | |   .|....|  .. ..||   .  | . . ||  . . .  .....  || | 
liGkraenedriklkeldpe...llyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaea..ellssGttatvs

-RKDSLRKAHSTTADC
  .|    . ... | 
llrdGtelvlaslGds
PP2C Protein phosphatase 2C 116-198 4.2e-08 26.1 Pfam-A 8-82 (255) alignment 
Range on Protein: 116-198
Range on HMM: 8-82/255.0
VLGRRPRMEDRFIIEENIN---NNTGISFFAVFDGHGGEFAADFAKDVLVkniyN---KIIEMSKLLktegnsgdydKSPYLARKQSRK
. |.|  |||. |...| .    .  ..||||||||||. ||..|.  |     .   . .. ..|           |   . ||. ..
lqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle....eilkeqksflele..........kvekalrksfla
PP2C Protein phosphatase 2C 116-198 4.2e-08 26.1 In-house 8-82 (255) alignment 
Range on Protein: 116-198
Range on HMM: 8-82/255.0
VLGRRPRMEDRFIIEENIN---NNTGISFFAVFDGHGGEFAADFAKDVLVkniyN---KIIEMSKLLktegnsgdydKSPYLARKQSRK
. |.|  |||. |...| .    .  ..||||||||||. ||..|.  |     .   . .. ..|           |   . ||. ..
lqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle....eilkeqksflele..........kvekalrksfla
subfamily_ILKAP_pd Subfamily ILKAP 118-171 1e-09 31.0 In-house 14-75 (293) alignment 
Range on Protein: 118-171
Range on HMM: 14-75/293.0
GRRPRMEDRFIIEENINNN--------TGISFFAVFDGHGGEFAADFAKDVLVKNIYNKIIE
| |  |.|  .| |.....        . .|..||||||.|. |..||.. | |.| .|. .
GereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk
PPM_PTC7 118-198 3.8e-08 26.1 In-house 10-82 (259) alignment 
Range on Protein: 118-198
Range on HMM: 10-82/259.0
GRRPRMEDRFIIEENIN---NNTGISFFAVFDGHGGEFAADFAKDVLVkniyNKIIEMSKLLKTEgnsgdydKSPYLARKQSRK
|.|  |||. |.. | .    .  ..||||||||||  ||..|.  |     ... | . . ..|       |     ||. ..
gfrksmedahialanlesssgkdsvaffavfdghggreaakyarehle....eilkerksfeele.......klekalrksfla
Subfamily Dicty-PPM1L-like 120-410 2e-16 52.7 In-house 18-300 (305) alignment 
Range on Protein: 120-410
Range on HMM: 18-300/305.0
RPRMEDRFIIEENINNNTGISFFAVFDGHGGEFAADFAKDVLvKNIYNKIIEMSKLLKTEGNSgDYDKSPYLARKQSRKDANKENTEPTAGVMRKDSLRK
|   |||      ....   |.| |||||.|. ||...|  |  .|.|| . . |  ..  |  . |..|  | |..  ...|   . . .  .|     
rkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkkl.veivnkyvkenkvGysaknl.nvddlpleaiksaslstdkssldsaesdnkkaGttl

AhSTTADCsAIKQKTTEASIADIYTVQLNSAMRASGNLGAAKDSFLNNNNNGQNGAANapppNYEAKCYIE--HGRINFG-KLITDEIMSADYKLVEQaK
   ..|    .... | .| |    | | |   |.|   .     .  .  |           |. . . .  . ||..    . .     . .|...  
n.gssasv.ilerertivstasdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnh....lynqnnfldeiririeslqaalynygellvnrllkk.s

RATNIAGTTALIAIVQGSKL-IVANVGDSRGVMYDwRGIAIPLSFDHKPQQVRERKRIHDAGGFI--AFRGVWRVAGVLATSRALGDyplkDKNLVI
|     ... |..  . |.|  ||. .|...|.    |..  ||.......|.|  |..  .. |   |  ..|| . .| .|  ||    . .|||
rskGdknlkelviPnndspllvvakanDqflvlat.dGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD....nitlvi
subfamily_PP2D1_pd Subfamily PP2D1 122-172 3e-08 25.8 In-house 16-66 (492) alignment 
Range on Protein: 122-172
Range on HMM: 16-66/492.0
RMEDRFIIEENINNNTGISFFAVFDGHGGEFAADFAKDVLVKNIYNKIIEM
 |||.. . ..  |..  .||...||. | .||. |   | . . ... ..
kmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekv
subfamily_PDP_pd Subfamily PDP 123-206 2e-08 26.8 In-house 11-94 (398) alignment 
Range on Protein: 123-206
Range on HMM: 11-94/398.0
MEDRFIIEENINNNtgISFFAVFDGHGGEFAADFAKDVLVKNIYNKIIEMSKLLKTEGNSGDYDKSPYLARKQSRKDANKE--NTE
.|||  . . ...|    .|.||||||| ..|.  .. |.| .  .... ..| ..| .  . ..   | .|.. |  ..   ...
iEDrrseakllesn..gvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekalesgkallkllkkskhkldvvsdeakk
subfamily_KAPP-like_pd Subfamily KAPP-like 129-198 1.8e-08 26.7 In-house 24-90 (266) alignment 
Range on Protein: 129-198
Range on HMM: 24-90/266.0
IEENINNNTGISFFAVFDGHGGEFAADFAKDVLVKnIYNKIIEMskLLKTEGNSGDYDKSPYLARKQSRK
 |....| . |..||||||| |  ||| ||... | . .| ..     . .|    ||.|  |    .  
kekklsncsnialfavfdGhaGkGaadaakklfpk.elekllks..tkqddGGdniydqskllenafkev
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 129-199 3.9e-08 25.5 In-house 23-95 (276) alignment 
Range on Protein: 129-199
Range on HMM: 23-95/276.0
IEENINNNTGISFFAVFDGHGGEFAADFAKDVLVKNIyNKIIEMSKLLKTE---GNSGDYDKSPYLARKQSRKD
 |....| . |..||||||| |  ||| ||... |.. .|... ..   |.   |    ||.|  |    .  |
dekdlsncsnialfavfdGhaGkGaadaakklfpkel.ekllksgnysltkqddGGdniydqskllldlfkevd
subfamily_PPM1H_pd Subfamily PPM1H 129-198 3.3e-07 22.4 In-house 52-116 (404) alignment 
Range on Protein: 129-198
Range on HMM: 52-116/404.0
IEENINNNTGISFFAVFDGHGGEFAADFAKDVLVKNIYNKIIEMSKLLKTEGNsgdydKSPYLARKQSRK
 |.. ...  . .|..||||.|. ||  |  .| | . .|. .. .||... .     ...  ....|..
kekseeeklplayfglfDGhaGsgaalvaskllhkhlkekledvlellleksa.....eeeenteesske
PP2C_2 Protein phosphatase 2C 256-446 1.5e-07 23.9 Pfam-A 82-188 (212) alignment 
Range on Protein: 256-446
Range on HMM: 82-188/212.0
NlgaakdsflnnnnngqngaanapppnyeakcyiehgrinfgklitdeimsadyK--LVEQAKRATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDWRG
.                                                     .    |...   .  .|| |.|.... .......||.. |..|  |
k.....................................................lkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdg

IAIPLSFDHKPQQVRERKRIHDAGGFIAFrgvwrvagvlatsralgdyplkdknlviatpdiLTFELNDHKPHFLILASDGLWDTFSNEEACT
 . .|. ... . ..|  .. ..  .  .                                  . .|. ...  |.| .||..| ...||. .
evqllgepdsgeyanettfltsedaeeel.................................rirrlklepgdalllmTDGvsdslrkeepfr
PP2C_2 Protein phosphatase 2C 256-446 1.5e-07 23.9 In-house 82-188 (212) alignment 
Range on Protein: 256-446
Range on HMM: 82-188/212.0
NlgaakdsflnnnnngqngaanapppnyeakcyiehgrinfgklitdeimsadyK--LVEQAKRATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDWRG
.                                                     .    |...   .  .|| |.|.... .......||.. |..|  |
k.....................................................lkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdg

IAIPLSFDHKPQQVRERKRIHDAGGFIAFrgvwrvagvlatsralgdyplkdknlviatpdiLTFELNDHKPHFLILASDGLWDTFSNEEACT
 . .|. ... . ..|  .. ..  .  .                                  . .|. ...  |.| .||..| ...||. .
evqllgepdsgeyanettfltsedaeeel.................................rirrlklepgdalllmTDGvsdslrkeepfr
subfamily_PPM1H_pd Subfamily PPM1H 267-373 2.4e-11 36.0 In-house 102-210 (404) alignment 
Range on Protein: 267-373
Range on HMM: 102-210/404.0
NNNNGQNGAA-N-APPPNYEAKCYiEHGRINFGKLITDEIMSA----DYKLVEQAKRATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDwRGIAIPLSF
.... ....  .    |.   ..| |. .|.  .|.   . ||    | .. .. .. .   | |||.|.|   || ||| |||| ..   ..  ||||.
ksaeeeenteesskespssvseiy.eekeiskeeLviGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvr.kdeiiplsa

DHKPQQvrERKRI
|. |.   ||.|.
dftPet..eRqRl
subfamily_PDP_pd Subfamily PDP 288-404 4.1e-11 35.6 In-house 118-241 (398) alignment 
Range on Protein: 288-404
Range on HMM: 118-241/398.0
YIEHGRINFGKLITDEIMSADYKLVEQAKRATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDWRG----IAIPLSFDHKPQQVRERKRIHDAGGFIAFR
 ....  .. | |..|....  . . . . .. ..|..||.| ..| .| |||.||.| |.   ..     |..|| |.  .  .| .||. .      .
alkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesk

GV---WRVAGVLATSRALGDYPLK
 |    |. | |. .|| ||. .|
tvirngRlLgeLqPlRAFGdvryK
subfamily_PPM1G2_pd Subfamily PPM1G2 297-480 1.1e-41 135.7 In-house 90-284 (287) alignment 
Range on Protein: 297-480
Range on HMM: 90-284/287.0
GKLITDEIMSADYKLVEQAKRATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDWRGiAIPLSFDHKPQQVRERKRIHDAGGFIAFRgvwRVAGVLATSR
 ... | ... | .|... | . . ||.||...... .||.|||.|||| |.      .  ||||||||.  |.||| .||||...    ||.|.|| ||
eqilkdafletDeellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgn.vkalsfDhkPqeesekkriiaagGfveln...rvngnLalsr

ALGDYPLKDKN-------LVIATPDILTFELNdHKPHFLILASDGLWDTFSNEEACTFALEHLKE---PDFGAKSLAMESYKRGSV------DNITVLVI
||||.  |...       .| |.||.|. .|. ..  ||.|| ||.|| ..|.| . .  |.|..   .|  ...| ... .. |       ||.||...
algDfefkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvviv
PP2C Protein phosphatase 2C 298-475 1.2e-51 168.8 Pfam-A 74-255 (255) alignment 
Range on Protein: 298-475
Range on HMM: 74-255/255.0
KLITDEIMS-ADYKLVEQAKR-ATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDWRGIAIPLSFDHKPQQVRERKRIHDAGGFIAFrgVWRVAGVLATS
|.. . ... .|..|  .... .    |.||..|...|.||.|||||||| |. . ....  |..||||.. .||.|| .|||..    ..|| |.|| |
kalrksfladtdeelksskantepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavs

RALGDYPLKD--KNLVIATPDILTFELNDHkPHFLILASDGLWDTFSNEEACTFALEHLKE---PDFGAKSLAMESYKRGSVDNI
|||||. ||.  . ||.| ||. ...|...  .||||||||||| .|..||. .. ..|..   |.  |. |. |...||| |||
RalGdfelkpkeeqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 298-475 1.2e-51 168.8 In-house 74-255 (255) alignment 
Range on Protein: 298-475
Range on HMM: 74-255/255.0
KLITDEIMS-ADYKLVEQAKR-ATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDWRGIAIPLSFDHKPQQVRERKRIHDAGGFIAFrgVWRVAGVLATS
|.. . ... .|..|  .... .    |.||..|...|.||.|||||||| |. . ....  |..||||.. .||.|| .|||..    ..|| |.|| |
kalrksfladtdeelksskantepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavs

RALGDYPLKD--KNLVIATPDILTFELNDHkPHFLILASDGLWDTFSNEEACTFALEHLKE---PDFGAKSLAMESYKRGSVDNI
|||||. ||.  . ||.| ||. ...|...  .||||||||||| .|..||. .. ..|..   |.  |. |. |...||| |||
RalGdfelkpkeeqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 298-475 2.8e-51 167.4 In-house 74-259 (259) alignment 
Range on Protein: 298-475
Range on HMM: 74-259/259.0
KLITDEIMS--ADYKLVEQAKR-ATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDWRGIAIPLSFDHKPQQVRERKRIHDAGGFIAFRGVWRVAGVLAT
| ... ...  .|..|  .... .    |.||..|...||||.|||||||| |. . .... .|..||||.  .||.|| .|||..   |..|| |||| 
kalrksflaldtdeelksseantepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlav

SRALGDYPLKD----KNLVIATPDILTFELNDHkPHFLILASDGLWDTFSNEEACTFALEHLKE--PDFGAKSLAMESYKRGSVDNI
|||.||. ||.    . ||.|.||| . .....  .||||||||||| .|..||. .. ..|..  |.  |. |. |...|||.|||
sRafGdfelkpketeeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
subfamily_PPM1E_pd Subfamily PPM1E 300-483 1.7e-43 141.7 In-house 80-263 (265) alignment 
Range on Protein: 300-483
Range on HMM: 80-263/265.0
ITDEIMSADYKLVEQAKRATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDwRGIAIPLSFDHKPQQVRERKRIHDAGGFIAFRGVWRVAGVLATSRALG
. . .  .| .....|.| .  .|.|| ........| || .|||....    | |. |   |||.. .|.||| .|||.. . |.||| |||. |||.|
lkeafkltDerflqkaereklksGstavvvliekdqlyvaWlGDsqallvr.kgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiG

DYplKDKNLVIATPDILTFELNDHKpHFLILASDGLWDTFSNEEACTFALEHLKEPD----FGAKSLAMESYKRGSVDNITVLVIVFK
|.  |.|. |.. .|. ..||.... ..||||.|||||.. .||...   |.|...       ||.|  .....|| |||||.|....
Dv..klkpyvsgeadvaeveldgse.eylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfld
subfamily_ILKAP_pd Subfamily ILKAP 300-480 3.6e-30 98.1 In-house 89-290 (293) alignment 
Range on Protein: 300-480
Range on HMM: 89-290/293.0
ITDEIMSADYKLVEQAKRATNI--AGTTALIAIVQGSKLIVANVGDSRGVMYDWRG-----IAIPLSFDHKPQQVRERKRIHDAGGFIAFRgvwRVAGVL
..|     | .....|..|. .   |.|| . .|    | |||.|||. |..         ....|. ||.| .  |||||. |||..      || |||
lvdsfkktdeefLklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg...rvlGvl

ATSRALGDYPLKDKNlVIATPDILTFELNDHkPHFLILASDGLWDTFSNEEACTFALEHLKEP-------------------DFGAKSLAMESYKRGSVD
  ||..||   |    ||.|||.   ||..    |..|| ||||..||..|.  |.|. |..                    .  .. || |. |||| |
evsrsiGdgrfkrlG.vistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssd

NITVLVI
|.|||..
nvtvllv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 302-415 2.2e-19 63.1 In-house 65-196 (292) alignment 
Range on Protein: 302-415
Range on HMM: 65-196/292.0
DEIMSADYKLVEQAKRATNIAGTTALIAIVQGS-KLIVANVGDSRGVMYD----WRGIAIPLSFDHKPQQVRERKRIHDAGGFIA--------FRGVWRV
  |..   || .    | . |.|..  |.|.   .||.||||||| ...      .   |||| ||||.   ||.||  |||..         |||  ||
lrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarv

------AGVLATSRALGDYPLKDKNlVIATPDI
       | || ||||||. |..   |.| |..
wrrrqqeGdlalsralGdfhlfeaG.vvaePel
subfamily_PPM1D_pd Subfamily PPM1D 305-456 2.4e-22 72.4 In-house 90-269 (309) alignment 
Range on Protein: 305-456
Range on HMM: 90-269/309.0
MSADYK-LVEQAKRATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDWRG-----IAIPLSFDHKPQQVRERKRIHDAGGFIAFR-GVWRVA--------
|   ..  .....     ||||| . |....|| ||.||||. |.          .| .|  ||||....|..||...|| .| . || ||.        
mkkkleeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprleh

-G--------VLATSRALGD---YPLKDKN-LVIATPDILTFELNDHKPHFLILASDGLWDTFSNEEACTFALEHLKEPD
 |         || .|.|||   |  | .. .|   ||.  ..|. .. .|.||||||||.  . |.| ..  .. .   
ngptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekke
subfamily_KAPP-like_pd Subfamily KAPP-like 310-447 1.2e-18 60.1 In-house 88-227 (266) alignment 
Range on Protein: 310-447
Range on HMM: 88-227/266.0
KLVEQAKRATNIAGTTALIAIVQ--G-SK-LIVANVGDSRGVMYdWRGIAIPLSFDHKPQQVRERKRIHDAGGFIAfRGVWRVAGVlATSRALGDYPLKD
| |..  .  .  |.|| .|.|   |  . | |||||||   .      .. ||.||| .. .|..||.| |  ..  .  |. |. | ||||||. .|.
kevdaklkdfeyeGatatlalvwsdGqqrylqvanvGdssafls.rGneslelskdhkakdpeekqrikddGitls.dnqtrinGl.avsralGdhfike

KNL-VIATPDILTFELNDHKPHFLILASDGLWDTFSNEEACTF
.|. .|..| .    |   . .|||.|||||||  | ..|   
lniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiek
subfamily_PPM1G_pd Subfamily PPM1G 314-456 2.2e-33 109.0 In-house 288-433 (473) alignment 
Range on Protein: 314-456
Range on HMM: 288-433/473.0
QAKRATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDwRGIAIPLSFDHKPQQVRERKRIHDAGGFIAFRGvwRVAGVLATSRALGDYPLKDK-------
..    . .|||| .|.... ||||||.|||| |.    | |. || ||||.   |..||. ||| .   |  || | |  ||||||.  | .       
ekeepGedsGttAvvaLlkekklivAnaGDsRcvlsr.nGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplke

NLVIATPDILTFELNDHKpHFLILASDGLWDTFSNEEACTFALEHLKEPD
 .. | ||| . .| ..  .||.||.||.|.. . .|   |  ..||. .
qmisAlPDikvltlteed.eFlvlAcDGiWnvmesqevvdfvraklkkge
subfamily_PPM1K_pd Subfamily PPM1K 314-483 2.7e-30 98.4 In-house 90-259 (263) alignment 
Range on Protein: 314-483
Range on HMM: 90-259/263.0
QAKRATNIAGTTALIAIV-QGSKLIVANVGDSRGVMYdWRGIAIPLSFDHKPQQVRERKRIHDAGGFIAFR--GVWRVAGVLATSRALGDYPLKDKNlVI
 |.. .. .|||| .... .| .|..|..|||| ..   .| |  |. ||.|..  |..||. |||....   |  .| |.|| .|.|||  ||    ||
vaeaellssGttatvsllrdGtelvlaslGdsrailc.rnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG.vi

ATPDILTFELNDHKPHFLILASDGLWDTFSNEEACTFaLEHLKEPDFGAKSLAMESYKRGSVDNITVLVIVFK
|||.  .....  .  ||.| .||. .  ...| | . ..  ..|.  |..|.  . . || || |..|. ..
atPetkslkvdhaadsflvlitdgisfvvnsqelcdl.vrlchdpeeaahalteqalqygsednatavvvplg
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 316-482 1.1e-40 132.5 In-house 89-253 (255) alignment 
Range on Protein: 316-482
Range on HMM: 89-253/255.0
KRATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDWRGIAIPLSFDHKPQQVRERKRIHDAGGFIAFR-GVWRVAGVLATSRALGDYPLKdkNLVIATPD
.  .   ||||  ... . | ..||||||| |. .  |.|  ||.||||.. .|.|||...||..       || | || ||||||  |.    |.. ||
serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle..PfvvpdPd

ILTFELNDHKPHFLILASDGLWDTFSNEEACTFALEhLKEPDFGAKSLAMESYKRGSVDNITVLVIVF
.     . .| .||||| ||.||  |.|||.  ...  ..|.  |. |   .|..|| |||.|.|| .
lsqsleiskkdkflilacdGiwdlisdeeaveivag.isdpekaaeklrdlayssGstdnisvivikl
PP2C_SIG_SM00331 318-480 9.9e-12 37.9 In-house 82-215 (217) alignment 
Range on Protein: 318-480
Range on HMM: 82-215/217.0
ATNIAGTTALIAIV--QGSKLIVANVGDSRGVMYDWRGIAIPLSFdhkpqqvrerkrihdaggfiafrgvwrvagvlATSRALGDYPLKDknlviatPDI
 ..  ..|.|.|..  ...|| .||.|||| .... ..   .|..                                 ....||  |  .       .||
eekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd................................vegaplGlepevs.......vdi

LTFELNDhkPHFLILASDGLWDT-----FSNEEACTFALEHLKEP-DFGAK--SLAMESYKRGS--VDNITVLVI
 ..||.     .|.|..|||..      | .|. ...  ...... .  |.     ......||   |.|||.|.
relelek..gdllllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvv
PPM_PTC7_SpoIIE 321-480 1.3e-25 83.5 In-house 90-227 (230) alignment 
Range on Protein: 321-480
Range on HMM: 90-227/230.0
IAGTTALIAIVQGSK--LIVANVGDSRGVMYDWRGIaiplsfdhkpqqvrERKRIhDAGGFIAfR--GVWRVAGVLATSRALGDYPLKDK-NLVIATPDi
  |.||..|....|.  | |||.|||. ....  |               ||.|| .|||..     . .||.|||| |.| ||. |...  .| | || 
ssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglps.lGilpgrvfgvlavslapGdllllytDGvveaepd.

LTFELNDHKPHFLILASDGLWDTFSNEEACTFALEHLKEPdfgakslameSYKRGSVDNITVLVI
   .. . | .|||||||||||  |..|.. .....|..|           ....  | ||.||.
tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp..........aaeglleDDitllvv
subfamily_TAB1_pd Subfamily TAB1 322-440 4.1e-11 35.2 In-house 129-261 (333) alignment 
Range on Protein: 322-440
Range on HMM: 129-261/333.0
AGTTALIAIVQGSKLIVANVGDSRGVMYD--WRGIAIPLSFDHKPQQVRERKRIHDAGgfIAFRGV--WRVAGVLATSRALGDYPLKD----K-------
 ||||..|..   || |||||||| ..           || ||. .   | .|..| |  .    .   .. |   . |..||| .|             
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLG..ldieqikrnkrlgskentRsiGdykvkkgykdvdilssak

-NLVIATPDILT-FELNDHKpHFLILASDGLWDTFS
 . |||.|||   ....| . .||.| |||.  |  
gePviaePdiqgaypiddit.yflvlmSdGvyktLe
subfamily_PP2D1_pd Subfamily PP2D1 331-452 5.4e-19 61.2 In-house 185-306 (492) alignment 
Range on Protein: 331-452
Range on HMM: 185-306/492.0
VQGSKLIVANVGDSRGVMYDWrGIAIPLSFDHKPQQVRERKRIHDAGGFIAFRG-VWRVAGVLATSRALGDYP-LKDKNLVIATPDILTFELNDHKpHFL
.. . | .||.|. . |.    | || |  .| |.  .||.|.. ||. .   . . .| |.| | | || |  .| |. ||  | . . .|....  ||
eelgvlyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaa.qfl

ILASDGLWDTFSNEEACTFALEHL
.||| |||. .|.||  . . . |
vlAsnGlWevlseeevlsLvkqtl
subfamily_PHLPP_pd Subfamily PHLPP 335-482 6.2e-11 34.7 In-house 106-245 (246) alignment 
Range on Protein: 335-482
Range on HMM: 106-245/246.0
KLIVANVGDSRGVMYDwRGIAIPLSFDHKPQQVrERKRIHDAGGFIAFRGvwRVAGVLATSRALGDYPLKdkNLVIATPDILTFELNDHKpHFLILASDG
.| ||.||    |.   .|  ..||  .. ..  | |||..| ..|   .  .. ||....| || . |     |. .| .    |..    .||. .. 
sLevAsvGtlqavliR.ngkklrlsksyviekd.elkrikeakaiitedn..kingviestrllGytflf..PvvlPkphvrevlLteqd.ellivGnka

LWDTFSNEEACTfALEHLKEPDFGAKSLAMESYKRGSVDNITVLVIVF
||...| .||   |. . ..|   || |       |  |...|||. .
lWevlsideave.avrkeedplvaAkklvdlaqsygaadsvsvlvvrl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 336-447 7.8e-17 54.0 In-house 128-237 (276) alignment 
Range on Protein: 336-447
Range on HMM: 128-237/276.0
LIVANVGDSRGVMYdWRGIAIPLSFDHKPQQVRERKRIHDAGGFIAfRGVWRVAGVlATSRALGDYPLKDKNL-VIATPDILTFELNDHKPHFLILASDG
| |||||||   .      .. ||.||| ..  |..||.| |  ..  .  |. |. | ||||||. .|..|. .|..| .    |   . .|||.||||
lqvanvGdssafls.rGneslelskdhkatdpeekqrikddGitls.dnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdG

LWDTFSNEEACTF
|||  | ..|   
lwdvisGkdaiek
Subfamily Dicty-PPM1L-like 368-483 1.1e-13 43.7 In-house 181-304 (305) alignment 
Range on Protein: 368-483
Range on HMM: 181-304/305.0
RERKRIHDAGGFIAFRGVWRVAGVLATSRALGDYPLKdkNLVIATPDILTFELNDHKPHFLILASDGLWDTFSNEEACTFALEHLKEPDFGA--------
 .| ||  ... .   |  .| ..|  ||  ||  ||   |||  .|   . ...    ||.|| ||||. .|...   . .| |..   .         
eiririeslqaalynygellvnrllkksrskGdknlk..elviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfne

--KSLAMESYKRGSVDNITVLVIVFK
  .  . |..|||| ||||...| .|
isrviveeavkrgsgDnitlviiklk
subfamily_PPM1H_pd Subfamily PPM1H 387-454 6.2e-08 24.8 In-house 276-353 (404) alignment 
Range on Protein: 387-454
Range on HMM: 276-353/404.0
RVAGVLATSRALGDYPLKDKN-------LVIATPDILTFELNDHK---PHFLILASDGLWDTFSNEEACTFALEHLKE
|. . ....| |||. ||  .       .. ..|.. ...|.. .    . ||||.|||||  ||||. .   | |..
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlsk
subfamily_PDP_pd Subfamily PDP 409-456 3.6e-09 29.2 In-house 270-316 (398) alignment 
Range on Protein: 409-456
Range on HMM: 270-316/398.0
VIATPDILTFELNDhKPHFLILASDGLWDTFSNEEACTFALEHLKEPD
..|.|.... .|.  . .||.||.|||||..||||. .   |||.. .
ltaePevtshklre.ndkFLvlatDGLwdllsneevvslVgehlakkk
PPM_PTC7_SpoIIE_motif 427-480 1.7e-07 24.8 In-house 14-78 (81) alignment 
Range on Protein: 427-480
Range on HMM: 14-78/81.0
FLILASDGLW-------DTFSNEEACTFALEHlK--EPDFGAKSLAMESYKRG---SVDNITVLVI
 |.|..|||.       ..|..||.. .| .. .  ...  |. |  |  ..|   . |.||.||.
vllLyTDGltEardsdgelfgkeellrladra.egkslqeladklvdevlengsgereDDitllvl
PPM_PTC7_motif 429-475 2.2e-12 40.3 In-house 1-51 (51) alignment 
Range on Protein: 429-475
Range on HMM: 1-51/51.0
ILASDGLWDTFSNEEACTFALEHLKE----PDFGAKSLAMESYKRGSVDNI
||||||||| .|..||. .. ..|..    |   |. |. |. .|||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni