Gene fig in Drosophila melanogaster

Synonym: CG7615, Dmel\CG7615, Dmel_CG7615, fig

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PTC7
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP138_AA protein Get Run
DmelP138_AA_61-309 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PP2C_2 Protein phosphatase 2C 62-241 9.6e-09 27.8 Pfam-A 6-184 (212) alignment 
Range on Protein: 62-241
Range on HMM: 6-184/212.0
RSNQRFGEDSWFVSSTPLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQLSDFD-GRSPRNMLIAGFQE-------LSHREHPVVGSSTACLATM
|... . .|.......  .... ||||.|  .   . |  ... .... . . . ....  .  .. . .. ..        . .....   .|..|...
rrkgkpcqDalaireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllav

hRKDCTLYTANLGDSGFLVV-RNGRVLHRSVEQTHDFNtPYQLTVPPEDRKESYycdkpemavST-RHSLLPGDLVLLATDGLFDNMPES
 ... ... ...||.. .|. |.|.|   . ......       ...||  |..          . |  | ||| .|| |||. |.. ..
.itpgeivffqiGDgaivvrdrdgevqllgepdsgeya.nettfltsedaeeel.........rirrlklepgdalllmTDGvsdslrke
PP2C_2 Protein phosphatase 2C 62-241 9.6e-09 27.8 In-house 6-184 (212) alignment 
Range on Protein: 62-241
Range on HMM: 6-184/212.0
RSNQRFGEDSWFVSSTPLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQLSDFD-GRSPRNMLIAGFQE-------LSHREHPVVGSSTACLATM
|... . .|.......  .... ||||.|  .   . |  ... .... . . . ....  .  .. . .. ..        . .....   .|..|...
rrkgkpcqDalaireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllav

hRKDCTLYTANLGDSGFLVV-RNGRVLHRSVEQTHDFNtPYQLTVPPEDRKESYycdkpemavST-RHSLLPGDLVLLATDGLFDNMPES
 ... ... ...||.. .|. |.|.|   . ......       ...||  |..          . |  | ||| .|| |||. |.. ..
.itpgeivffqiGDgaivvrdrdgevqllgepdsgeya.nettfltsedaeeel.........rirrlklepgdalllmTDGvsdslrke
subfamily_PPTC7_pd Subfamily PPTC7 63-309 1.5e-105 345.1 In-house 6-251 (252) alignment 
Range on Protein: 63-309
Range on HMM: 6-251/252.0
SNQRFGEDSWFVSSTPLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQLSDFDGRSPRNMLIAGFQELSHREHPVVGSSTACLATMHRKDCTLYT
..|..|||..||||.  |.|.||||||||||. |.|...|..|||..|. ... |... ..|...| |..|||.....||.||||||.......|..|..
krqkageDayfvsseksadvlgvADGVggWrsvGiDpsefsreLmkaceklskeskaeelkPvelleaayqelleekvpvlGssTacivvldksdkkles

ANLGDSGFLVVRNGRVLHRSVEQTHDFNTPYQLTVPPEDRKESYYCDKPEMAVSTRHSLLPGDLVLLATDGLFDNMPESMLLSILNGLKERGEHDLLVGA
||||||||||||.|.|..|| ||.|.|||||||...||.|......||||.|.|..... .||...|||||||||..|...|.||. |||. ...| . |
anlGDSgflvvRkgkvvfrskeqqhkfntPyQLsiapegregkvildkpeaadsksfavkkgDiivlatDGlfDNlledeileilkelkeseksslqsla

SRVVEKARELSMNASFQSPFAIKARQHNVSYSgGGKPDDITLILSSV
....|||||||......|||| ||.......| ||||||||.....|
kklaekarelsldpeyespfaqkakkngleas.GGKpDDitvvvavv
PP2C_SIG_SM00331 64-306 1.3e-16 53.8 In-house 13-214 (217) alignment 
Range on Protein: 64-306
Range on HMM: 13-214/217.0
NQRFGEDSWFVSSTPL-AEVMGVADGVGgwrdLGVDAGRFAKELMSCCSGQTQLSdfdgRSPRNMLIAGFQELSHREHPVVGSSTACLATMHRKDCTLYT
 .....|. .| ...    .. ||||.|     |..|. ....| .    . .       .. ..| .  . . ....   .  |..|| .. .. .|. 
atqvsGDyydvvklnegrlllvvaDgmG....kGlaAaaassqlrtalrellseg....eelsqalkrlnraiyeekeekgmfaTlllalydfssgklsy

ANLGDSGFLVVRngrvLHRSVEQTHDfNTPYQLTVPPEDRkesyycdkpemAVSTRHSLLPGDLVLLATDGLFDNMPES-----MLLSILNGLKerGEHD
||.||| ....|     .. ||...| .....| . || .           . ..  .| .|||.||.||||.... |       |  ||  |   ....
anaGdsrpyllr....dgklveilkd.vegaplGlepevs...........vdirelelekgdllllytDGltearsekgfaeerleeiledlv..dsea

LLVGAsRVVEKARELSMNA-SfqspfaikarqhnvsysgggkPDDITLIL
  ... . ||.. ||. ..                       .||||...
qelaq.kiveellelakgsng.....................eDdiTvvv
0049733 PP2C-like 66-306 1.2e-31 103.0 In-house 16-230 (235) alignment 
Range on Protein: 66-306
Range on HMM: 16-230/235.0
RFGEDSWFVsstpLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGqtqlsdFDGRSPRNMLIAGFQEL--------SHREHPVVGSSTACLATMHrkD
. .||...|       ...||||.||..  .| .... . |.... .      ..  .....|.. |...         ....  .. .||..| ..  .
kvneDavlv....glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspelagmgtTavvalld..g

CTLYTANLGDSGFLVVRNGRVLHRSVEQTHDFNTPYQLTVPPEDRKESYYC--------DKPEMAVSTRHSLLPGDLVLLATDGLFDNMPESMLLSILNG
 .||.||.||| ....|.|........... .....|  . ....   ..         | .  .  |.. | |||..|||.|||.|..........|..
gklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggavrvpgrlaltralGdlllkpdvtvlelepgdflllasDGlwdvlsdeeivdllrs

lkergeHDLLVGASRVVEKARElsmnasfqspfaikarqhnvsysgGGKPDDITLIL
      .||   |.|.|| |..                        .|..|.||...
......ldleeaaerlvelala........................rggrDNiTvvv
0034914 PP2C-like 66-306 1.9e-29 95.6 In-house 33-287 (295) alignment 
Range on Protein: 66-306
Range on HMM: 33-287/295.0
RFGEDSWFVSS-----TPLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQLSDFDGRSPRNMLIAGFQEL--------SHREHPVVGSSTACLAT
.  ||...|       ..   ..||.||.||..   | . .. ..|....  ...|....  .....|. .|...         .| .  ....||..| 
ksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallrpelagsGtTavval

MhrKDCTLYTANLGDSGFLVVRNGRVLHRSVEQTHDFNTPYQLTVPPEDRK-----------------------------ESYYCDKPEMAvSTRHSLLP
.  .. .||.||.||| ....|||.... .|........ ..  . ....                              | .    |..  ... .| .
i..rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvt.vleltled

GDLVLLATDGLFDNMPESMLLSILNGLKErGEHDLLVGASRVVEKARElsmnasfqspfaikarqhnvsysgGGKPDDITLIL
.|..|||.|||.|..... ...|.. | . . .|| . | ..|. | .                        .|. |.|| ..
ddfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAla........................rgsrDNiTvvv
PP2Cc_SM00332 67-187 4.7e-08 25.7 In-house 23-151 (274) alignment 
Range on Protein: 67-187
Range on HMM: 23-151/274.0
FGEDSWFVSST----PLAEVMGVADGvggwrDLGVDAGRFAKELMSCCSGQTQLSDFD--GRSPRNMLIAGFQELSHREHPVVG-------SSTACLATM
 .|| ..|         . ..||.||       | .. .|... .  .. ..  .. |    .. . |  .|...  .             .| ... ..
smeDahvvvvdlveeedwlffgvfDG.....hgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelenalsGstavva

HRKDCTLYTANLGDSGFLVVRNGRVLHRSVEQTH
. |. .|| ||.|||   ..||| ..  ||... 
llkkedlyvanvGDSravlcrngkavqlsvdhkp
PPM_PTC7_SpoIIE 82-245 9.3e-16 51.3 In-house 34-173 (230) alignment 
Range on Protein: 82-245
Range on HMM: 34-173/230.0
VMGVADGVGgwrdLGVDAGRFAKELMSCCSGQTqLSDFDgrSPRNMLIAGFQELSHREHPV--VGSSTACLATMHRKDCTLYTANLGDSGFLVVRNGRVl
.  |.|..|     |..|  ....| ..   .    ...   | . |......|....     .. .||..|  .  . .||.||.||| .|.||...  
alvvgdvdG....hGgraalamgllrtalrela.fagle..kpeeilrrlnlalaadledepsssgaTavvalidpstgklyvanaGdsppllvrddgg.

hrSVEQTHDFNTPYqLTV-PPEDRKEsyycdkpemavsTRHSLLPGDLVLLATDGLFDNMPEsmllS
   .|..  .. |. | . |  . ..            .. || |||| ||.|||. .. |.    .
..ererivagglps.lGilpgrvfgv............lavslapGdllllytDGvveaepd....t
SpoIIE Stage II sporulation protein E (SpoIIE) 83-308 5e-14 44.6 Pfam-A 7-191 (193) alignment 
Range on Protein: 83-308
Range on HMM: 7-191/193.0
MGVADGVGgwrdLGVDAGRFAKELMSCCSGQTqLSDFDgrsPRNMLIAGFQEL-SHREHPvVGSSTACLATMHRKDCTLYTANLGDSGFLVVRNGRvlhR
..|.|.||     |..|  .. .| |        .. .   | ..| .  . | .. |.  .   ||.|| .. .. .|. ||.|.. .|.||. .   .
lvvgDvvG....hGleAalimgllrsalrela.tagle...paevlerlnealarnleee.erfatavlaeydpstgkleyanaGhpppllvrpdg...g

SVEQTHDFNTPyqLTVPPEdrkesyycdkpEMAVSTRHSLLPGDLVLLATDGLFDNMPESMLL----SILNGLKERGEHDLLVGASRVVEKARElsmnas
 ........ |  | . ||           . . ...  | ||||.||.|||..... .   |      |. |.|. ...|   ....||...|      
tkfllvstglp..lGilpe...........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle......

fqspfaikarqhnvsYSGGGKPDDITLILSS
                ..|.. |||||..  
...............lgsgeleDDitllvlr
SpoIIE Stage II sporulation protein E (SpoIIE) 83-308 5e-14 44.6 In-house 7-191 (193) alignment 
Range on Protein: 83-308
Range on HMM: 7-191/193.0
MGVADGVGgwrdLGVDAGRFAKELMSCCSGQTqLSDFDgrsPRNMLIAGFQEL-SHREHPvVGSSTACLATMHRKDCTLYTANLGDSGFLVVRNGRvlhR
..|.|.||     |..|  .. .| |        .. .   | ..| .  . | .. |.  .   ||.|| .. .. .|. ||.|.. .|.||. .   .
lvvgDvvG....hGleAalimgllrsalrela.tagle...paevlerlnealarnleee.erfatavlaeydpstgkleyanaGhpppllvrpdg...g

SVEQTHDFNTPyqLTVPPEdrkesyycdkpEMAVSTRHSLLPGDLVLLATDGLFDNMPESMLL----SILNGLKERGEHDLLVGASRVVEKARElsmnas
 ........ |  | . ||           . . ...  | ||||.||.|||..... .   |      |. |.|. ...|   ....||...|      
tkfllvstglp..lGilpe...........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle......

fqspfaikarqhnvsYSGGGKPDDITLILSS
                ..|.. |||||..  
...............lgsgeleDDitllvlr
PPM_PTC7 97-188 2.7e-08 26.6 In-house 46-142 (259) alignment 
Range on Protein: 97-188
Range on HMM: 46-142/259.0
VDAGRFAKELMS-CCSGQTQLSDFDgrSPRNMLIAGFQELS----HR------EHPVVGSSTACLATMHRKdctLYTANLGDSGFLVVRNGRVLhRSVEQ
  |...|.| .  .   . .. ...   . . |. .|..|.    ..      |.  .||.  ...  . |   ||.||.|||.....|.|..    . .
reaakyarehleeilkerksfeele..klekalrksflaldtdeelksseantepstsGstAvvalitgsk...lyvAnvGDSravLcrsgnav.kqlte

THD
.|.
dHk
PP2C Protein phosphatase 2C 123-188 4.8e-06 19.3 Pfam-A 71-141 (255) alignment 
Range on Protein: 123-188
Range on HMM: 71-141/255.0
SPRNMLIAGFQE------LSHR---EHPVVGSSTACLATMHRKdctLYTANLGDSGFLVVRNGRVLhRSVEQTHD
  .. |. .|..       |..   |.  .||.  .    . |   ||.||.|||  ...|...    .. ..|.
kvekalrksfladtdeelksskantepsksGstavvalirgkk...lyvAnvGDSravLcrkdnak.keltedHk
PP2C Protein phosphatase 2C 123-188 4.8e-06 19.3 In-house 71-141 (255) alignment 
Range on Protein: 123-188
Range on HMM: 71-141/255.0
SPRNMLIAGFQE------LSHR---EHPVVGSSTACLATMHRKdctLYTANLGDSGFLVVRNGRVLhRSVEQTHD
  .. |. .|..       |..   |.  .||.  .    . |   ||.||.|||  ...|...    .. ..|.
kvekalrksfladtdeelksskantepsksGstavvalirgkk...lyvAnvGDSravLcrkdnak.keltedHk
PP2Cc_SM00332 203-305 3e-06 19.8 In-house 194-272 (274) alignment 
Range on Protein: 203-305
Range on HMM: 194-272/274.0
KESYYCDKPEMAVSTRhsLLPGDLVLLATDGLFDNMPESMLLSILNGLKERGehdllvgASRVVEKARELSMNASFQSpfaikarqhnvsysgGGKPDDI
|| |   .|.. | |      .....||.|||.|.. .  . .|.. |...|       .   ...| || ...  ..               ||. |.|
kepyitaepdvkvvtl..tsedeflilaSDGlwdvlsnqevvdivrkllakg.......ktndpqeaaelldeeairr...............ggseDni

TLI
| .
Tvv
PPM_PTC7_SpoIIE_motif 217-309 4.8e-09 29.8 In-house 5-80 (81) alignment 
Range on Protein: 217-309
Range on HMM: 5-80/81.0
TRHSLLPGDLVLLATDGLFDNMPESMLL----SILNGLKERGEHDLLVGASRVVEKARElsmnasfqspfaikarqhnvsYSGGGKPDDITLILSSV
..  | |||..||.||||.... .   |      |  .... ...|   | ..|....|                     ...|.. |||||..  |
aefqLkpgdvllLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevle.....................ngsgereDDitllvlrv