Gene ALPL in Homo sapiens

Synonym: AP-TNAP, APTNAP, HOPS, TNAP, TNSALP, ALPL

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP002_AA protein Get Run
HsapP002_AA_19-492 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0037220 Alkaline phosphatase-like 20-492 7.2e-173 565.7 In-house 3-470 (479) alignment 
Range on Protein: 20-492
Range on HMM: 3-470/479.0
PEKEKDPKYWRDQAQETLKYALeLQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLC
. ..... ... .|...| .|| |..||...|||||.|.||||||||||||||..|||... |||..| .||||.|.|.|||.....|.|||..|||...
lllllllllllllalallllal.llllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlat

GVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMhNIRDIDVIM
|||.| |..||.|...|. |... ||.|..||..||.|||..|.|||||..||||.| |||.|.|.|..| ...  .|..||||||.||.   ...|||.
GvKtnngaigvdadvsrdncddplgnpvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleagckdiatqlv.lgsgldvil

GGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRykhSHFIWNRTELLTLDP-HNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQ
||||||..||...|.||...   .|.|||| ||.. .|. |.     ....||.||..||. .|||.|||||......|||.|.. ..|||.||. .|..
GGGrkyflpkgtldpeydlelllggkrldgrdlleeakekkkg...ytyvtnreeldaldlgsnvdkllGlfadshlpyeldrdaseePsLaemtekAld

ILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLsDTDKKPFTAILYGNG
.| ||.|||||.||||||||..|...|. ||.|....|.|.. |  ... .|||.||||||||.....||. |||.|.||.| | ..| .|.|..||.||
lLskndkGFfLmvEggriDhagHandaaaalgevlafdeaveaalefakdddTlvvvtADHshgglilgyadrgnpilgllpgl.lldglpyttllyang

PGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGA
||.... ..|........ .. .. ...|.. ...|.||||.|.  ||.|.|..||.|.....||.|.|...| 
pgflllldlrldltllvtlallllqralvgwtsggHtgedVpvyayGpgaelflgvyentdiahviasalglgl
subfamily_AP_pd Subfamily AP 25-492 5.5e-204 668.8 In-house 2-468 (472) alignment 
Range on Protein: 25-492
Range on HMM: 2-468/472.0
DPKYWRDQAQETLKYALELQkLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKAN
..|.|...|||.|| |||||  |.. |||||.|||||||||||||||||||||... |||..|....||.|.|||||....||||||.||||||||||.|
sakfwlkkaqeelkealelq.snskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktn

EGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLM--HNIRDIDVIMGGG
.||.||.||.||..|....|.||.|||..||.|||..|.||||||.||.|...|||.|.|.|.||.|.| || ..||||||.||.  .. ...|||.|||
ngtiGvdaaverkdCeasagkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeaekegckdiaqQLieeevgkeldvilGGG

RKYMYPKNKTDVEYESDekarGTRLDGLDLVDTWksfKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRK
||...||...| |||..    |.| || .|...|   . . |......||.||...|....|.|||||......||..|.. ..|||.||. .|...|.|
rkkflpktvkdseyekk....gerkDgrnLieew...ekekknakyvenrkelenvdksktdrllGlfadshlkyeidrdekeePsLkemtekAlevLsk

NPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYK
|..||||.||||||||.|||.|||.||.|..|.|.|. .| .||..||||.||||||||..|. ||. ||.||.|||.. ...|..|.|...| |||||.
nenGffLfVEggrIDhahhenkakkaleetlefdeavelaleltdeedTlivvtaDHshtltiagypkrgssilglakesksadelpyttlsyangpgye

VVG-----GERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGA
        |||.... .. ....|. |.||||..||||||||||...||..|||.||.||....||||||||.|.
ltesdleegerkdlteaeteakdyvsqaavpleeetHggeDvavyasGpqshlltGvveqstiahvmayaaclge
Alk_phosphatase Alkaline phosphatase 51-490 2.6e-183 600.3 Pfam-A 1-421 (421) alignment 
Range on Protein: 51-490
Range on HMM: 1-421/421.0
AKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETrLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSaatersrcntTQGNEVTSI
|||||...|||||||||||||.||.| ....|||. |..|..|.|.|||||....||.|||.|||||.||||...|..||.          |.|.||.|.
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

LRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVeyesdEKARGTRLDGL
|..||.||||.|.||||||.||||.| .||.|.|.|..|.... .| ..|.||||.||... ..|||..|||||...|....|      ||.||||||| 
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde.....ekerGtrldgr

DLVDTWksfkpRYKHSHFIWNRTELLTLDPHN-VDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQAL
.|.. .     . ........|.|||    .| |..|||||..||...||.|.. ..|||.||. |||..| ||.|||||||||.||||..||..|..||
nlieea.....kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavgal

HEAVEMDRAIGQAGSLT-SSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVP
.|.||.|.|. .|  .. . ..||.||||||||||..||||.||.||.|||......|.|....||||||.|.|| .|.||||.. ......|...|||.
sEvvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakvedgarenvtaeealekiyrkrsavg

LRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACI
|..|.|.||||||| .||.|.|..||.||.....|.|.|...
ltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
Alk_phosphatase Alkaline phosphatase 51-490 2.6e-183 600.3 In-house 1-421 (421) alignment 
Range on Protein: 51-490
Range on HMM: 1-421/421.0
AKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETrLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSaatersrcntTQGNEVTSI
|||||...|||||||||||||.||.| ....|||. |..|..|.|.|||||....||.|||.|||||.||||...|..||.          |.|.||.|.
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

LRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVeyesdEKARGTRLDGL
|..||.||||.|.||||||.||||.| .||.|.|.|..|.... .| ..|.||||.||... ..|||..|||||...|....|      ||.||||||| 
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde.....ekerGtrldgr

DLVDTWksfkpRYKHSHFIWNRTELLTLDPHN-VDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQAL
.|.. .     . ........|.|||    .| |..|||||..||...||.|.. ..|||.||. |||..| ||.|||||||||.||||..||..|..||
nlieea.....kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavgal

HEAVEMDRAIGQAGSLT-SSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVP
.|.||.|.|. .|  .. . ..||.||||||||||..||||.||.||.|||......|.|....||||||.|.|| .|.||||.. ......|...|||.
sEvvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakvedgarenvtaeealekiyrkrsavg

LRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACI
|..|.|.||||||| .||.|.|..||.||.....|.|.|...
ltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel