Gene ALPPL2 in Homo sapiens

Synonym: ALPG, ALPPL, GCAP, ALPPL2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP004_AA protein Get Run
HsapP004_AA_20-493 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0037220 Alkaline phosphatase-like 21-493 6.5e-177 579.0 In-house 2-474 (479) alignment 
Range on Protein: 21-493
Range on HMM: 2-474/479.0
IPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
........ .....| ..| .|..|.. .. |||.|.|.||||||||||||||..|| ...|| |..||.|.||.|.|.||||||. |.|| |.|||...
llllllllllllllalallllalllllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlat

GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILG
||| |. .||..|......|....||.| ... .||.|||..|.|||||..||.||. |||..||||..|..... . ..||.||||||. ....|||||
GvKtnngaigvdadvsrdncddplgnpvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleagckdiatqlvlgsgldvilG

GGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSR
|||||..| ||.||||.... .||.||||..|..|. .|..|..||.||.||....|...|..|.|||......||..|| . .||| ||||.|| |||.
GGrkyflpkgtldpeydlelllggkrldgrdlleeakekkkgytyvtnreeldaldlgsnvdkllGlfadshlpyeldrdaseePsLaemtekAldlLsk

NPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
|..||||.||||||||..|.  |..||.|...||.|.|.| ......||| .|||||||.....||. ||..|.||.||.. | ..|| |||.||||..|
ndkGFfLmvEggriDhagHandaaaalgevlafdeaveaalefakdddTlvvvtADHshgglilgyadrgnpilgllpgllldglpyttllyangpgfll

KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTAC
  . |.|.|     .. ..|...|... ..| ||||.|.|.||.|.|..||.|.|.||||.|.|..|.... .
lldlrldltllvtlallllqralvgwtsggHtgedVpvyayGpgaelflgvyentdiahviasalglgllevl
subfamily_AP_pd Subfamily AP 27-491 2.2e-204 670.2 In-house 2-470 (472) alignment 
Range on Protein: 27-491
Range on HMM: 2-470/472.0
NPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNF
...||...|.|.| .| .||.... |||.|.||||||||||||||||||||.|..|| |. ||...||||.||||||.||.|||| ||||||||||| |.
sakfwlkkaqeelkealelqsnskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktnn

QTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLI---SNMDIDVILGGGR
.|||..||.....|....|.|| |....||||||..|.||||||.||||||.|||. ||||.||..|||.|..|||.|||.|||   .....||||||||
gtiGvdaaverkdCeasagkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeaekegckdiaqQLieeevgkeldvilGGGr

KYMFPMGTPDPEYPDDysqgGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDpSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPR
|...|....|.||...    |.| ||.||..|| .....|.||.||.||.... . ....|.|||.....||||.||.. .|||.||||.|| .||.|..
kkflpktvkdseyekk....gerkDgrnLieewekekknakyvenrkelenvdks.ktdrllGlfadshlkyeidrdekeePsLkemtekAlevLsknen

GFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAP-GKARDRKAYTVLLYGNGPGYVLKD
|||||||||||||.|||..|..||.||..||.|.|.| .||.||||| .|||||||.... ||| |||||.|||.  |..|...||.|.| |||||.|..
GffLfVEggrIDhahhenkakkaleetlefdeavelaleltdeedTlivvtaDHshtltiagypkrgssilglakesksadelpyttlsyangpgyelte

-----GARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYT
     |.| |.||.|.....|..|.||||. |||.||||||.|.|||.||..||.||..||||||.||||....
sdleegerkdlteaeteakdyvsqaavpleeetHggeDvavyasGpqshlltGvveqstiahvmayaaclgeae
Alk_phosphatase Alkaline phosphatase 52-487 4.1e-190 622.7 Pfam-A 1-421 (421) alignment 
Range on Protein: 52-487
Range on HMM: 1-421/421.0
AKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETfLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSaaarfnqcntTRGNEVISV
|||.|...|||||||||||||.||.|.|.|||.|. ||.||.|.|.|||||.|||.|.||.||||||.|||| . ..||..          |.|.|| ||
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

MNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNM-DIDVILGGGRKYMFPMGTPDPeypddYSQGGTRLDGK
...|||||||.|.||||||.||.||. .||...|.|..||...|||..||..|||.|||... .|||.||||||...|.||.|.     ... ||||||.
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde.....ekerGtrldgr

NLVQEWlaKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTET
||..|.  |..|..||..|.|||.|. ..||..|.|||..||.|.|..||.. .|||.||||.|. |||.|..||||.|||.||||..||..|..||.|.
nlieea..kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavgalsEv

IMFDDAIERAGQLT-SEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKA-RDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDG
..||.|...| ... .|..|| .||||||||||.|||. ||.||.|||. |. .|.||....|||||.|. ..||||..||..|... .||..|||.|. 
vefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakvedgarenvtaeealekiyrkrsavglts

ETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACL
|.|.||||||||.||.|.||.|||||| ||.|.|.|..|
eeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
Alk_phosphatase Alkaline phosphatase 52-487 4.1e-190 622.7 In-house 1-421 (421) alignment 
Range on Protein: 52-487
Range on HMM: 1-421/421.0
AKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETfLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSaaarfnqcntTRGNEVISV
|||.|...|||||||||||||.||.|.|.|||.|. ||.||.|.|.|||||.|||.|.||.||||||.|||| . ..||..          |.|.|| ||
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

MNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNM-DIDVILGGGRKYMFPMGTPDPeypddYSQGGTRLDGK
...|||||||.|.||||||.||.||. .||...|.|..||...|||..||..|||.|||... .|||.||||||...|.||.|.     ... ||||||.
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde.....ekerGtrldgr

NLVQEWlaKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTET
||..|.  |..|..||..|.|||.|. ..||..|.|||..||.|.|..||.. .|||.||||.|. |||.|..||||.|||.||||..||..|..||.|.
nlieea..kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavgalsEv

IMFDDAIERAGQLT-SEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKA-RDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDG
..||.|...| ... .|..|| .||||||||||.|||. ||.||.|||. |. .|.||....|||||.|. ..||||..||..|... .||..|||.|. 
vefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakvedgarenvtaeealekiyrkrsavglts

ETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACL
|.|.||||||||.||.|.||.|||||| ||.|.|.|..|
eeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel