Gene PPP1CB in Homo sapiens

Synonym: HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD, PPP1CB

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP134_AA protein Get Run
HsapP134_AA_5-303 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049330 Metallo-dependent phosphatases 6-303 1.3e-116 381.9 In-house 7-304 (309) alignment 
Range on Protein: 6-303
Range on HMM: 7-304/309.0
LNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICL
| ...||..||..   .. |.....| |.. |. | .||..|.|.||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||...|
llllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlll

LLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLW
|||.|..||.|.||||||||.. .|..|||.||..|.....||. |.|....||.||....||.|.||||||||....|||...||...|..||||||||
llalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllw

SDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAK
|||. .. |...|.||....||...| .||....||||.|.|..|..||..|....|.|.||||||||...|.|... .||.|..||....|.. . .
sdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll
subfamily_PPZ_pd Subfamily PPZ 7-300 4.5e-139 456.0 In-house 2-296 (300) alignment 
Range on Protein: 7-300
Range on HMM: 2-296/300.0
NVDSLITRLLEVR-GCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICL
..| .| .||.    ..  | | . ..|.  .|||.||.||.|| ||||  ..|| ||.||||.||||||   |||| |||||||||||||||||||| |
dideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletill

LLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLW
||.||||||||||||||||||| . |.|||||||||| |||.|||| | || ||.||||  |||| |||||| |.||..||...||||||| ||. ||||
llcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllw

SDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
|||    . | .|.||||. .    . ||||.  .||.|||| |||||||||  | |||.|||||||||||| | .||| | |.|||..| | . 
sdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 7-301 2.2e-138 453.3 In-house 2-297 (298) alignment 
Range on Protein: 7-301
Range on HMM: 2-297/298.0
NVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLL
.||.|....|.|       . ...|..|  |. ....|| .|. |.|..||.|.||||||||.||||||. .||||.|||||||||||||.|.||.|.||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRF-NIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLW
||||.|||.|||||||||||..|||.||||.|||||. ...|...| | || ||..|.. ..|.| |||||. |.|..|.|.. ||.| ... |  ||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

SDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKK
.||.. |.|| || ||||..||.||| ..|.. |.||..|||||| |||||||...|||.||||.|||.|||. ..|.||| |..||..|||..|.
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 7-303 8.8e-130 425.3 In-house 2-299 (299) alignment 
Range on Protein: 7-303
Range on HMM: 2-299/299.0
NVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLL
.|| |...||.|          . | |.. ||  ....|.||. |||.|||...||||||||.||||.|.  ||||..|.||||||||||.| ||.|.||
dvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFN-IKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLW
|..||||||.||.||||||| .|||.||||.||..|..  .||  | |.|. .|.. ..  .|.| |||||| ||...|.| . || | |.  |  ||||
lcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllw

SDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAK
.|||. |..|  | ||||. || |||.. ..| |.||..||||||.|||||||...|||.|||| |||.|||.  .| ||| |.|.|..|||..|..|
adpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpkslk
0053225 Metallo-dependent phosphatases 11-298 9.5e-107 349.6 In-house 4-291 (293) alignment 
Range on Protein: 11-298
Range on HMM: 4-291/293.0
LITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYK
||..||..   .  ......| |.. |... .||....|.||||.... ..|||||...|||.|.|. ||||| ...||||.|||| .|||...||||.|
lilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalk

IKYPENFFLLRGNHECASINRIYGFYDECKRRF-NIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPD
..||.|..|||||||.. .| .|||.||..|.. . .||. ..|....||.||....||...|||||||| ...|||.|.||...|..|||.||||||||
llypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd

kDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPS
 .. ||. . ||....||...| .||....||||.|.|||| |||... ...|||.||||||.|...|.|... .|| |...|....|.
.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_PPP1C_pd Subfamily PPP1C 21-300 3e-163 534.7 In-house 2-281 (282) alignment 
Range on Protein: 21-300
Range on HMM: 2-281/282.0
CRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
...|| |...|||.. |. |.|||.||||||||||||.||.|||||||.|||||||..|.|||.|||||||||||||||||||.||||||||||||.|||
skkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfll

RGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDR
|||||.||||||||||||||||..|||||||||.|||||.||.|||||.|.||||||.|.|.||||.|.||..||..|||||||||||||.|.||.||||
rGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
|||||||.|||.|||...|||||.||||||||||||||||||||.||||||||||||||...||||.|..|||||||..|
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
0045823 Metallo-dependent phosphatases 24-302 3.1e-118 388.3 In-house 38-328 (473) alignment 
Range on Protein: 24-302
Range on HMM: 38-328/473.0
GKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGN
 |. ...| ... |. . .||. ..| ||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||...||||.|||||.|.||||||
kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGN

HECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPdKDVQG--------W
||.. .| .|||.||. ......|.. | .....||.||....||...||||||||....|||.| || ..|| |||.|||||||  .. |        .
HElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlrff

GENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQ------LVTLFSAPNYCGEFDNAGGMMSVDETLmCSFQILKPSEKKA
| . ||....||.|.| .||....||||.|.|..|..|||.. ...      ..|.||||||||...| .... .||.| .||....||. . 
gnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphpl
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 26-298 3.7e-107 351.0 In-house 20-295 (297) alignment 
Range on Protein: 26-298
Range on HMM: 20-295/297.0
IVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
   .||  |  |   . ..| .|  ..|..||.|.|||||||. ||||||  ||.|| |||||||||||||. |.||| ||||||.|.| |.||||||||
skviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhe

CASINRIYGFYDECKRRF-NIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSP---DLQSMEQIRRIMRPTDVpDTGLLCDLLWSDPDKDVQGWGENDRG
|  .|..||||.||..|.  .... .| | || ||.. .. .||.| ||||||   .  ... .|.| |.|.    .|..||||.||   . |. ||.||
cefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrg

VSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPS
    || | | |     .|||.|||||||.||||||| |.|||.|||| |||.|||.  .||.|| | |||.||.|.
agcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_PPP2C_pd Subfamily PPP2C 27-301 1.2e-101 332.8 In-house 15-289 (290) alignment 
Range on Protein: 27-301
Range on HMM: 15-289/290.0
VQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHEC
 |..|.||. || | .||. ..  . |...|. .|||.|||. ||| ||  ||  |..||||||||||||  |.||..|| | |..|.|   .|||||| 
kqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhes

ASINRIYGFYDECKRRF-NIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDkDVQGWGENDRGVSFT
  | ..||||||| |.. | ..|| ||| |..||..|.|||.||| |||||| ......|| . |  .||. | |||||||||| | .|||  .||  .|
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagyt

FGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKK
|| |.  || .. .| || ||||.| .||..  .|..||.|||||||    | .... .|..|  ||   .|. ..
fgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 27-299 1.2e-100 329.3 In-house 6-278 (281) alignment 
Range on Protein: 27-299
Range on HMM: 6-278/281.0
VQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHEC
||.|. |.  .  . . || ..  | |...| .. ||.|.|..|| ||||  | .||  ..|||||||||.||||.. ||...||.|... .||||||| 
vqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhei

ASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTF
||.|.||||| ||. .. ..||  |  ||| |||.| ..... | ||||||.| .....| . .| . .| ||. ||||.|||..|..| .  ||.||||
asvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftf

GADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSE
| .|| .   | ...|| |||||| |||| .. |.|.|.||.||||  . ||. .. |||||  |.. | |. 
GknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 27-294 2.2e-78 256.5 In-house 18-288 (307) alignment 
Range on Protein: 27-294
Range on HMM: 18-288/307.0
VQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHEC
.| |  |.  .  ... || |.  |.... |  . ||.|||. ||. .|   | |||. |.| |||||||  |||.| ||..||| ||||  ||||||| 
iqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhei

ASINRIYGFYDECKRR---FNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVS
| .|. ||||.||         ..|  |  ||| |||.|..  ||.| |||||| |  ....|   .|   |  |.. |.||.|||  |  |    ||  
arvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsg

FTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQI
||||..|.    .|  ..|| ||||.. |||  .. |.|.|.|||| ||  . ||| .. |||||      
ftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlva
subfamily_PPP4C_pd Subfamily PPP4C 28-297 1.3e-103 339.2 In-house 15-284 (288) alignment 
Range on Protein: 28-297
Range on HMM: 15-284/288.0
QMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 ..| ||. || |.|||.. .  . ....|  .|||||||. |||.||. ||  || |||||||.||||. |.||. ||||.|..||..  |.|||||. 
likeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesr

SINRIYGFYDECKRRF-NIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDkDVQGWGENDRGVSFTF
.| ..||||||| |.. ....|.  |. |. |..|||.|.|||| ||||||.......|| | | ..||. | |||||||||. |..||.   ||  . |
qitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylf

GADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKP
|.|||..| .. |..|||||||.| .|| .  .....|..||||||    |   .. .||.|   |.|.. 
gsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifea
subfamily_PPP6C_pd Subfamily PPP6C 28-296 9.2e-93 303.5 In-house 14-282 (290) alignment 
Range on Protein: 28-296
Range on HMM: 14-282/290.0
QMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 ..|.... || .  ...| .  .  ...|. .|||||||. ||. ||  ||  |...|.||||.||||  ||||. .||. |.|||..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRF-NIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPdKDVQGWGENDRGVSFTF
 | ..|||||||.... | . || .|. |. |.||||.||...| |||||||.. ..||| | | ...|  | .|||.|||| .||. |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagylf

GADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILK
|. |...|..  .|.|||||||.||.|.... . .|||..||||||    |   .......   .....|
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 29-300 1.2e-121 398.1 In-house 6-277 (280) alignment 
Range on Protein: 29-300
Range on HMM: 6-277/280.0
MTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
. ||.. ..  | ..|.. |  ..|..||...|||.|||||||||||.  .|||. ||||||||||||.| || |.||||||..||.||..||||||..|
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

INRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGA
||| |||.||.|||.. .|.. | . .. ||..|.|  .|.| |||||..|.|........|| | .|  |  ||||.||...| ||.|| ||||  |||
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

DVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
.|| .. .. |.|||.| ||||.|||||||...|||.||||.|.|||||. ... ||| |. ||..|||. .
nvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalr
PP2Ac_SM00156 29-298 3e-116 380.2 In-house 1-270 (271) alignment 
Range on Protein: 29-298
Range on HMM: 1-270/271.0
MTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
... ||. |. ...||. ... |.|..||. ..||||||..|||||.| .|.||| .|.|||||||||.||.|.|.||.|.||.|||...|||||||. |
lskeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsss

INRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGA
.|.||||..|.||. . .... |...|..||.||.||.||.| ||||||.|.|...||.. |. . |. |||.|||||||.....|.  . ||.|..||.
vnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPS
|.|..||....|.||.|||.||..||||||...|||.|||||||.||.|.. ...|...|..|.. ||. 
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
PPP_3 29-296 1.5e-113 371.3 In-house 2-270 (271) alignment 
Range on Protein: 29-296
Range on HMM: 2-270/271.0
MTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
..| |.. |. | .||. ....|.|..||...|||||||..|||.||..||..|| .||||||||||||.|||...||||.|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFG
||..|||..|.. .. . |..|.....|..||.||..|||....||||||...|..||... |...||..|.|.|||.|..... .|.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

ADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILK
.||...||....|.||.|||...|.|||.......||.|||||||....||| .....|.|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 29-297 1.1e-112 369.2 In-house 8-282 (284) alignment 
Range on Protein: 29-297
Range on HMM: 8-282/284.0
MTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFP------PEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRG
..| |.  ||...||.|  ... ||.|||.||.||||||. ||| |..  |.|       | .|||||||||||  |.| | ||.|||...|.. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGV
|||   .|. |||| |||.|.  .|...|  .||..|..|.|..||.| |||.| || ...|. .. ||.|.|| |...|| |.||...|.|. | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKP
  .|||. | .||....|||. |||||| ||||||| |.|||.|||| |||..||.. ...||| |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 29-300 6.7e-97 316.9 In-house 10-284 (287) alignment 
Range on Protein: 29-300
Range on HMM: 10-284/287.0
MTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
... ..  .  | .||.   | |||.|||..|.||||||. ||||.|.  | .|. .||||||||||| .||| . ||...||.||..  |||||||.  
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

INRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDT--GLLCDLLWSDPDKDVQGWGEND-RGVSFT
||..|||..| ||... .|.|.| | |. ||. |.|...|.| |||.||.|.|..... . .||   .   ||  ||||.||.|| ..   |  |..|  
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

FGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
||  .| ..|.. |.||| |||.|.|.||.|.....|||.|||| |.||  | | .. |...|  ||  ||| . 
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
subfamily_PPP3C_pd Subfamily PPP3C 29-289 8.1e-88 288.1 In-house 41-314 (452) alignment 
Range on Protein: 29-289
Range on HMM: 41-314/452.0
MTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
..|...  .  .. ... ... |||.|||. ..||||||. |||.||| || | ...|||||||||||  |.|..  |.| ||.||...|||||||||  
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

INRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWG-------ENDRG
.   . | .||| ... .........|..||.||..... .|.||||||...|...|... |  ..| .|.||||||||| .| .          .. ||
lteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrG

VSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAK------RQLVTLFSAPNYCGEFDNAGGMMSVDETLM
 |. ..   |..||.. ||  | |||.. ..||. . |        |.||||||||.. ..| . .. ...  |
csyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 29-298 1.7e-87 286.4 In-house 6-275 (280) alignment 
Range on Protein: 29-298
Range on HMM: 6-275/280.0
MTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
||  |.  .      ||. .  | | |||.|. |||| || |. |||.  |  || . .||||||||| | .| . ||.. ||.| .  .|||||||  |
mtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetps

INRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGA
.|.||||| ||. .. . ||  |  ||| .|..... ....| ||||||.|  .. || | || .  | ||| ||||||| .  .||  . ||.|. || 
vnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgk

DVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPS
 || .  .  ..||| ||||||.||||..| |.|.|.|| |||| .| ||  .. ..  |  ||| | | 
gvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_PPG1_pd Subfamily PPG1 29-295 4.8e-85 278.4 In-house 14-293 (300) alignment 
Range on Protein: 29-295
Range on HMM: 14-293/300.0
MTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
. |. |. |. | .|.....  . |...|. . ||.|||. |.| .|. ||  |..||||||||||||  |.||| ||.. |..||    |||||||   
lpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrq

INRIYGFYDECKRRF--NIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPD---------KDVQG--W
| ..|||| || |..  | ..|| .|. |. | .|||.||.|.| ||||||. .|..||. . |  .||. | |.|||||||.          | .|  .
itqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhf

GENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQIL
 . .||  ...| ||| |||.  |.. | ||||.. .||. .   .| |..||||||    |   .. . | .   |.. 
vvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 29-297 4e-69 226.1 In-house 6-299 (302) alignment 
Range on Protein: 29-297
Range on HMM: 6-299/302.0
MTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPP-----------EANYLFLGDYVDRGKQSLETICLLLAYKIKYPENF
... |.  |. .  | .  .  | |. .|. | ||||||. ||.|.. .                .  ..|||||||||..|.| |||..|.|. ||.|.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FLLRGNHECASINRIYGFYDECKRRFN----IKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDTGLLCDLLWSDPdKDV
 |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.| |||.| |||.|| |.|.|.|..| || ..| .  |  |||..||  ||
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadp.ldv

QG---------WG-ENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKP
|.         .  .. ||.|..|    | .. .| .|.|| ||||..  |. |||...|.|.||||.|  | || | .. ||     | ..|..
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 29-296 9.3e-69 224.9 In-house 7-299 (302) alignment 
Range on Protein: 29-296
Range on HMM: 7-299/302.0
MTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPP-----------EANYLFLGDYVDRGKQSLETICLLLAYKIKYPENF
... |.  |. .  | .  .  | |. .|. | ||||||. ||.|.. .                .  ..|||||||||..|.| |||..|.|. ||.|.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FLLRGNHECASINRIYGFYDECKRRF----NIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDTGLLCDLLWSDPdKDV
 |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.| |||.| |||.|| |.|.|.|..| || ..| .  |  |||..||  ||
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadp.ldv

QG---------WG-ENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILK
|.         .  .. ||.|..|    | .. .| .|.|| ||||..  |. |||...|.|.||||.|  | || | .. ||     | ..|.
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 29-81 3.7e-17 55.5 In-house 9-61 (317) alignment 
Range on Protein: 29-81
Range on HMM: 9-61/317.0
MTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFP
..|.|.  || ..||.| ..|. ||||||..|.||||||. ||| |..  |.|
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 29-81 6.8e-13 41.4 In-house 11-63 (339) alignment 
Range on Protein: 29-81
Range on HMM: 11-63/339.0
MTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFP
.  ||.  || ..||.  |.||.|.||||. . ||||||. ||| ...  |.|
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
PPP_1 30-283 2.4e-114 374.1 In-house 2-263 (264) alignment 
Range on Protein: 30-283
Range on HMM: 2-263/264.0
TEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.|.|.. |. |..|.. ....|||.......|||||||..|||.||..||..|| |||||||||||||.|.|...||||.|.|||...||||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECK-RRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLL-------WSDPDKDVQGWGENDRG
...|||..|.. .... ...||.||.|..||.||..||||...||||||.|....|||...| |.||..| |||||       .||.... ... ...||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMS
....||.||..|||....|.||.|||.|.|.||||..||..||.|||.||. |..|.| ...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 30-298 7.1e-84 274.2 In-house 17-289 (290) alignment 
Range on Protein: 30-298
Range on HMM: 17-289/290.0
TEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.. ..  .  | .||.   | |||.|||. | ||||||  .||| |.  |.||. ..|||||||||| .|||   ||. |||.|...  |||||||.  .
sdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkv

NRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTD--VPDTGLLCDLLWSDPDKDV-QGWG-ENDRGVSFT
||.|||..|  |. . .||| . | |. |.. | |..||.| |||.|....| | .. . .|      | ||  ||||.||..|  .    .  |..|  
nrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvv

FGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPS
|| ... ..|..  |.|| |||.| |.|..|  ...|||.|||| |.|.  | | .. | |.|  |. .||| 
fgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 32-303 9.7e-111 362.7 In-house 6-279 (284) alignment 
Range on Protein: 32-303
Range on HMM: 6-279/284.0
AEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 .|  | ... .||  ||.|.| ..|..||||||||..||||||.  |||  ||||||||||||||. |||| ||.|||. .|. ||.|||||||. ||.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

IYGFYDECKRRFNI-KLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTG-LLCDLLWSDPDKDVQGWGENDRGVSFTFGAD
|||||.||.||.|   ....|   |  .|..|.| ..|.| |||.|  || . |.| | || | |.   |  |.||||| .  .||  | ||||. ||.|
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

VVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAK
 . |.|.| ..||. ||||||.|||||||.|.|||.|||| |||.||||  .| |.. |.||| .|.| .| |.
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiar
subfamily_PPPLV_pd Subfamily PPPLV 36-285 5.2e-58 189.6 In-house 4-276 (290) alignment 
Range on Protein: 36-285
Range on HMM: 4-276/290.0
GLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLL----RLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 || .. .|....  ||||..|  . ||.||.| ||      |.  |     |..||||||||||. |.| |. ||| |. ||  ..|||||||  |.  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRFNIKL---WKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQI---RRIMR--PTDVPDTGLLCDLLWSDPDKD-----------V
 . .. |.. .|  .|   |..|...|. ||.||..|.|.||.|.|.    ..  .|   . |.   . |.  . |  |.|||||..|            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

QGWGEND-RGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGgMMSVD
.|. .|| || .  |..| . .||.| .|. . |||.| | |...  | .|.|.||. .|||  ..|  .. ||
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaa.lilvd
subfamily_PPP5C_pd Subfamily PPP5C 40-287 2.9e-82 269.2 In-house 45-298 (322) alignment 
Range on Protein: 40-287
Range on HMM: 45-298/322.0
KSREIFLSQPILLELEAP----LKICGDIHGQYTDLLRLFEYGGFPPEA-NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYG
...|.. ..| |.|.. .    | .|||||||. ||| .||  | | |   ||| ||.||||  |.|.| .||..|. ||..||| |||||  ..|..||
eakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyG

FYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGL-SPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKdVQGWGENDRGVSFTFGADVVSK
| .|.| ... |. . ||. || ||.| ...||.. .|||| | |  .....|.| | .. |. |||..||||||..  .| ..  |||...|| || .|
fegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskrGvgvqfGpdvtkk

FLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSV-DET
||.  .|.|| |.|.| |.|||.  . .|.|.||||||| . .| |..... .. 
flkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgdd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 51-299 1.3e-75 247.4 In-house 2-257 (263) alignment 
Range on Protein: 51-299
Range on HMM: 2-257/263.0
LLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNI-----
||||.||..|||| |||| ||||.|.  |   ...||||||||||| .||| | ||.. |.  | ...|||||||  .||. |||. | |.||.      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDT-GLLCDLLWSDPDKDVQGWGEND-RGVSFTFGADVVSKFLNRHDLDLI
 ... | . |. .|..||| ..|.| |||.|| |.|...|| |  | .   |  | |||||.||.|| .|.  |  | .|  ||   |  . .| |.|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSE
 ||||||| || ||| |.|.|.|||  |  |. |   .. |.. |  ||  ||| .
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
Metallophos Calcineurin-like phosphoesterase 58-249 1e-45 149.4 Pfam-A 3-198 (200) alignment 
Range on Protein: 58-249
Range on HMM: 3-198/200.0
LKICGDIHGQYTDL----LRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLL--LAYKIKYPENFFLLRGNHECASINRIYGFYDECK-----------
  ..||.||.. ||    |.|.. .. ..  ..|||||.||||. |.||..||  |..|...| ..||||||||. ..|  |||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIrrimrptdvpdtgllcdllwsdpdkdvqgwge
                        . . . .  . ..|..||..|.|| ||...||.||....| ..|                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ndrgVSFTFGADVVSKFLNRHDLDLICRAHQV
     |. || |...|.|.....||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 58-190 3.8e-38 124.2 In-house 66-201 (383) alignment 
Range on Protein: 58-190
Range on HMM: 66-201/383.0
LKICGDIHGQYTDLLRLFEYGGFPP-EANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRF---NIKLWKTFTD
. .|||.||.  ||| ..   |.|  | .|.| ||.|||||.|.| ...|||. . ||....| |||||   .|  |||  | . ..   . |. ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPIAAIVDEKIFCCHGGLSpDLQSMEQIRRIMR
 |  ||.|...||||. .|||.| |  ..| . .| |
vfawlplatlidekilivhGGis.dktdlelldkier
PPP_2 59-249 3.5e-83 271.1 In-house 2-197 (198) alignment 
Range on Protein: 59-249
Range on HMM: 2-197/198.0
KICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECK-RRFNIKLWKTFTDCFNC
..|||.|||..|||.||..|...|| .||||||||||||.|||...||||.|..||....|||||||....|..|||..|.. .. . |..|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLL----WSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQV
||.||..|||....|||||.......||... |....|..|.|.|||    .|||... ... .. ||....||.||....|....|.||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 59-249 2.2e-79 259.1 In-house 2-196 (197) alignment 
Range on Protein: 59-249
Range on HMM: 2-196/197.0
KICGDIHGQYTDL-LRLFEYGGFPP-EANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFN
 ..||||||..|| |.|...||.|. | .|.||||||||||.|||...||||.|..||....|||||||..|.|..|||..|.... . ...|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DTGLLCDL-LWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQV
.||.||..|||....|||||..|.|...|.|| |....| . ....|| ||||| .. .|. .. ||....||.||..|||....|.||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 59-250 3.2e-75 245.5 In-house 2-199 (199) alignment 
Range on Protein: 59-250
Range on HMM: 2-199/199.0
KICGDIHGQYTDL-LRLFEYGGFPP-EANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRR-FNIKLWKTFTDCF
 .|||.|||. || |.||. ||.|. | .|.||||||||||.|||...||||.|..||....|||||||. ..|.||||..|....  . |..|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DTGLLCDL-LWSDPDKDVQG-WGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVV
..||.||..|||....||||||...|.|....| |....| ..|  .|| ||||| ....| . .. ||....|| ||..|||....|.||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_YNL217W_pd Subfamily YNL217W 59-178 7.7e-09 28.4 In-house 13-139 (235) alignment 
Range on Protein: 59-178
Range on HMM: 13-139/235.0
KICGDIHGQYTDLLRLFE--YGGFPPEANYLFLGDYVDRGKQSLETICLLlaykikYPENFFLLRGNHECASIN------RIYGFYDE-CKRRFN---IK
 . ||.|| | .|..|..   ||  ...  ...|| ...| .|.|.. ..        ..   ..|||| . .       .  |. .     .|.    |
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsflesk

LWKTFTDCFNCLPIA-AIVDEKIFCCHGGLSPD
| |  ..    |. .  |  ....  |.||.| 
lskadmeyarelgfsldipsdellvvhaGlvpg
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 84-298 1e-97 320.2 In-house 101-315 (317) alignment 
Range on Protein: 84-298
Range on HMM: 101-315/317.0
ANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSME
 .|||||||||||  |.| . ||.|.|..||.. ||||||||  ..|. |||| |.|.|.. .|...|   ||.||..|.|..||.| |||.| .| ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMS
|. .. ||.|.|| |.|.|| |.|||..|.|. |  || .. |||. | .||...||||. |||||||||||||| |.|||.||||.|||..||.. ..|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDETLMCSFQILKPS
||. |..|...|.|.
vdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 85-301 4.4e-74 242.6 In-house 121-337 (339) alignment 
Range on Protein: 85-301
Range on HMM: 121-337/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQ
 |||||||||||  |.| . || | |. ||.  .|||||||  |.|  |||| | . |.. .|.. | . || .|..|.... |.| |||.|  | |..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSV
.  . || ..|| |.| || |.|||   .|.    || || ||   .  ||.. ||... | |||||||||||  |.|||.||||||||. ||.  ..|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DETLMCSFQILKPSEKK
|. |  | ....|  . 
dkklkisinvfrpesrd
subfamily_PPP7C_pd Subfamily PPP7C 200-293 1.2e-20 66.6 In-house 237-330 (383) alignment 
Range on Protein: 200-293
Range on HMM: 237-330/383.0
LCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQ
. |.||||| ..   . .  ||    ||.|| .|.|....|.|. |.|.   .||||  .....|.||| ||  |  | |  . . ..|.  . 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpriv