Gene PPP2CA in Homo sapiens

Synonym: PP2Ac, PP2CA, PP2Calpha, RP-C, PPP2CA

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP136_AA protein Get Run
HsapP136_AA_3-295 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
YqzH YqzH-like protein 1-44 8.6e-06 13.7 Pfam-A 1-47 (64) alignment 
Range on Protein: 1-44
Range on HMM: 1-47/64.0
MDEKVFTKELDQWIEQL---NECKQLSESQVKSLCEKAKEILTKESN
||||  .| . . ..|    .|.| ||.   |.|.|| .|. ..|..
MdeklieKmirkclrqYgydaelkplskeeqkeLiekiqeakneeed
subfamily_PPP5C_pd Subfamily PPP5C 3-291 2.2e-84 276.2 In-house 14-308 (322) alignment 
Range on Protein: 3-291
Range on HMM: 14-308/322.0
EKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCP----VTVCGDVHGQFHDLMELFRIGGK-SPDTNYLFMGDYVDRGYYSVETV
||. .. ... .|.... |.| .  . ..  .|||.| |.. . |.. .    .|||||.||||.||...|.. |. |..  ||| ||.|||| .|||..
ekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsvevi

TLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSI-DTLDHIRALDRLQEVPHEGPMC
 .|...|. | ... . |||||| .. ..||| .|.  || ...| . ||..|..|||. ... ... .||||  .   |||..| .|| .. |.|| ..
ltllgfkllyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllv

DLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL-DDTLKYSFLQFDP
.||||||... | . | || | .|| |... | . |.|.|. |.|.. .|||.  || ...|.||||||| . ||..|...| .| ||  | .|. 
ellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfea
0053225 Metallo-dependent phosphatases 4-293 1.4e-110 362.2 In-house 3-292 (293) alignment 
Range on Protein: 4-293
Range on HMM: 3-292/293.0
KVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVAL
....  ||..||.|  .|.|||.... |...||||| ||.|..|.. ...|.||.||...||..|... |  |.....|.||.||||..|.|...|| ||
slilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllal

KVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDP
|..|......||||||.......|||.||.|||||.|..|....|....|||.||..|.|.. ||||||....||.|| ..| ...|.||...|||||||
kllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdp

DDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
|.. ||..|.||.|..|| .. . | ..|||.|. |.||.|..|| ...|...||.||||||..|.||..|...||. |...| .|.| .
dlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 4-293 3e-100 328.1 In-house 5-295 (298) alignment 
Range on Protein: 4-293
Range on HMM: 5-295/298.0
KVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVAL
..... | . ... . .|...|..|..|.|.||.|..| . . ||  |..||||.|||. ||. ||  .|  ||.||||.||||||| ...|...||.| 
ellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllay

KVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDP
||.| ... .||||||  .| .|||||.|| |.| . .... | |.|. ||||||. |.|.|.|||||. . .||..|.| | .. ..|    ||||.||
kvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadp

DD-RGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
..   ||  . ||....||.|  . . .   . || ||||.| .||..  ....|||||||.|| .  | ||.|..|. |. ||  . |. 
enavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
0049330 Metallo-dependent phosphatases 5-295 1.6e-114 375.0 In-house 12-302 (309) alignment 
Range on Protein: 5-295
Range on HMM: 12-302/309.0
VFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALK
.... ||..||.|  .|.|||.... |..|||||| .|.|..|.  ...|.||.|||..||..|... |  |.....|.||.||||..|.|...|| |||
lilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalk

VRYRERITILRGNHESRQITQVYGFYDECLRKYGnANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD
..|......||||||.|.....|||.||.||||| |..|..|.|....|||.|...|.|.| ||||||.. .||.||.|.| .|.|..|..||||||||.
llypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdpl

-DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRR
 .| |.. .|||.|..|| .. | | . |||.|. |.|..|..|| ...|....|.|||||||.|.||..|..|.|..|..|||.|.|.|. 
piregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
subfamily_PPP2C_pd Subfamily PPP2C 7-296 4.1e-194 636.2 In-house 1-290 (290) alignment 
Range on Protein: 7-296
Range on HMM: 1-290/290.0
TKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVR
.|.||..||.|.|||||.||.||.|||||||||.||||||||.||||||||||||||||.|||.||||||||||||.|||||||||||||||||||||||
ikdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvr

YRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR
|.||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||.|||||||||||||||.|||||||||||
ykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr

GGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRG
|||||||||||||||.||||.||..|||||..||||||||||||.||||||||||||||||||||||||.||||.|||||||||||||||
ggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprrg
subfamily_PPP7C_pd Subfamily PPP7C 7-185 8.6e-39 126.3 In-house 17-201 (383) alignment 
Range on Protein: 7-185
Range on HMM: 17-201/383.0
TKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRC----PVTVCGDVHGQFHDLMELF-RIGGKSPDTNYLFMGDYVDRGYYSVETVTLLV
..|... ||...| |.|    |  .  .||..| .  |...|       ||||||.||.. ||. .. . |  |.. .|.| ||.||||  ||| . .|.
kdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillill

ALKVRYRERITILRGNHESRQITQVYGFYDECLRKY--GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDtLDHIRALDR
|| . | . . . |||||   .   |||  |   ||   .... . . |.| .|||..|.| .|. .|||.| . | |. .  ..|
alllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkier
subfamily_PPP4C_pd Subfamily PPP4C 9-293 5e-151 494.8 In-house 2-286 (288) alignment 
Range on Protein: 9-293
Range on HMM: 2-286/288.0
ELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYR
.||. ||.|..|. ..|..||.||.||.||| .|||||.| .|||||||.||||.||.|||..||. |.|||||.||.||||.|||||  ||.|||||| 
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

ERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGG
.|||..||||||||||||||||||||||||.||||.| |..||||.|.|..||.|||.||||||||.|||.||..|| ||||||||.||||||||.|  |
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
|..||||||| ||.|..|.||.||...|..||||||||||..  ...|.|..||||||||||| |||.|||..|.. |  |. |.
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPP6C_pd Subfamily PPP6C 9-290 7.4e-140 458.1 In-house 1-282 (290) alignment 
Range on Protein: 9-290
Range on HMM: 1-282/290.0
ELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYR
|||.|||. ..|| |.|...| ||.. ...| .||||| |..|||||||.||||.||.|||| ||. |||.|.|.||.|||||||.||.|.|..||..| 
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

ERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGG
.|||.|||||||||||||||||||||.||||||.|||.|..|| |...|..|.|..|.|||||| . |||.|| ..| ||.||.|..|||.||||.|   
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
| .||||||| ||. ... |.| | | |..||||||.||...  | ..||..||||||||||| |.|..|.|. . ..  |.
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
0045823 Metallo-dependent phosphatases 9-294 3.4e-121 398.0 In-house 29-326 (473) alignment 
Range on Protein: 9-294
Range on HMM: 29-326/473.0
ELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYR
 ||..||.| ....|.|.....|...||||| ||.|..|.  ...|.||.|||..||..|... |  |.....|.||.||||..|.|.. || |||..| 
dldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikyp

ERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGG
.....||||||.|.....|||.||.|.|| .......| .....|||.|...|.|.. ||||||....|| ||...| .|.|..|...|||||||..  |
gnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddg

--------WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRN------VVTIFSAPNYCYRCGNQAAIMELDDTLkYSFLQFDPAPR
        .| |||||||.||.|. | | . |||.|. |.|. |.|||....|..      ..|.|||||||.|.|| ||....|..| .|| ||||.| 
dgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph
subfamily_PPG1_pd Subfamily PPG1 10-294 4.8e-132 432.7 In-house 1-298 (300) alignment 
Range on Protein: 10-294
Range on HMM: 1-298/300.0
LDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRE
||. .|.|. .. | |. ||.|..| ||.| |||||.|.|.|||| |||||||.|..|.|.|||. |||||||.|||||||.|||||..||..||.||  
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITILRGNHESRQITQVYGFYDECLRKY-GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD----
|||.||||||||||||||||| |||||| ||..||||.|..|||| |.|..| .|.|.|||||||. ..| |. |||..|||.|| ..|||||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DRGG--WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
      || |  . .|.|||||..|.|. | | . | .  . |||||..|||.   |  . |..|||||||||||.|.|.|| . ... |  .. ||.
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
subfamily_PPP3C_pd Subfamily PPP3C 12-280 9.4e-89 291.2 In-house 30-311 (452) alignment 
Range on Protein: 12-280
Range on HMM: 30-311/452.0
QWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERI
   | . .  .|.|...  . |.| ..| ||... ||  |.||.||.||||.||..|| .||.  .|.|||.||||||||.|.|.|  | |||. | ...
vlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstl

TILRGNHESRQITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGI
 .||||||.| .|. . | .||  ||.. .|.. ... || |||.||...| .|.|||||| | .|| |. |||..|.|. ||.|||||||| .. |   
fllrGnhecrhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeek

--------SPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHD------RNVVTIFSAPNYCYRCGNQAAIMELDD
        |.||  | ..   . .| ..| |  . |||.   .||.  ..        ..|.||||||.    |.||......
teekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 18-291 2.9e-68 223.0 In-house 11-288 (290) alignment 
Range on Protein: 18-291
Range on HMM: 11-288/290.0
NECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGN
   . .|.... .. ||..|||     . ||  |... ||.|||. .|.. |   |. |. ..||.|||||||  |.|   ||  .|.|| ... .||||
gvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgn

HESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR--LQEVPHEGPMCDLLWSDPDD--RGGWGI-S
|| |.. ..|||..|  ||  ....|| . |.|. |.| | |. .|.|.|||.|. |.. . ..|| .   .   .|| . ||||.||.        .  
hevrkvnrlygfkeelarkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnk

PRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
 |.    ||..  ... .  .| |. |||..  ||.|.  |...||.|||| |. .  |  ||... ..|. |.  . |
qraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 19-292 5.1e-87 284.5 In-house 4-275 (280) alignment 
Range on Protein: 19-292
Range on HMM: 4-275/280.0
ECkqLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNH
.|  . | ..... || |.||| .. . || .||.||||.|||. ||. ||   .  ||.||||.||||||| . .| . ||.| |||| ... ||||||
ac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnh

ESRQITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD-DRGGWGISPRGAG
|  .| . |||.||. |.| . .... | .|.| |||.||| |.|.|.|||||. . .||... | |  . ..|    ||||.||. .  ||. ..||. 
evisinrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

YTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPA
. ||...   . .   . |. | ||.| .||..  |...||.||||.|.    |.||.. .|. |. ||  . ||
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 19-290 5.1e-77 252.0 In-house 19-293 (297) alignment 
Range on Protein: 19-290
Range on HMM: 19-293/297.0
ECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNH
 .| ..| .|  | . | ... .. .. || .|. ||||.|||| ||. ||. ||  | .||||.||||||| .|.||. ||.| ||..   . .|||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSP---SIDTLDHIRALDRLQEVpHEGPMCDLLWSDPD-DRGGWGISPR
|   . .|||||.|| ..|    ..  | |.|..|||| |.  .|.|.||||||      ||| .| ..| .|  .|. ..||||.||     |.    |
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqr

GAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
|||  ||.|          | || ||||.| .||..   |..||||||| || .  | ||.|  |. |. ||  . 
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_PPP1C_pd Subfamily PPP1C 20-290 9.4e-107 349.4 In-house 7-277 (282) alignment 
Range on Protein: 20-290
Range on HMM: 7-277/282.0
CKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHE
  .|.|.....|..||.|||.... . |.. ||...||.|||..||. || ..|  |..||||.|||||||  |.||..||.|.|..| |.. .||||||
evklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhe

SRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGY
| .|...||||||| |.|..  .|| ||| |..|||.|||| .|.|.||||||... |..|| . |  |||..| .|||||||||. . ||. . ||  .
sasinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsf

TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
|||.|. |.| . | | |. ||||.| .||..  .|..||.||||||| . .|..|....|..|. ||  . 
tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 20-295 1.2e-89 293.6 In-house 21-297 (299) alignment 
Range on Protein: 20-295
Range on HMM: 21-297/299.0
CKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHE
 | . | ....||. ||....... . ||  |. ||||.|||. ||. .| . |  ||.|.||.|||||||   .|..|||.. |..| ||. .||||||
tksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhe

SRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGY
   | .|||||.|| ..|  . .|  | | |...||| |. ..|.|.|||||| ..||| .| | | |. |      ||||.|||.   .|    ||  |
cpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsy

TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRR
 ||||. .   .  .. ||.||||.| .||..  ....||||||| || .  | ||||..|. |  .|  . |.|..
vfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 20-290 1.4e-83 273.6 In-house 4-281 (284) alignment 
Range on Protein: 20-290
Range on HMM: 4-281/284.0
CKQ-LSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKS------PDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERIT
|.. |.| ..  || .|.|.. ||.  .|...||...||.|||| ||. |. . |         ...|||.||||||| .|.| .||| |.|... ....
cqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvf

ILRGNHESRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGI
.|||||||| . . |||| || ..| .| ... |   |  .||.|.|. .|.|.|||.|  .  |. . .|.|  ..|  | ..|| |.||. .  |.  
llrgnhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegyke

SPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
|||||| .||..  . |..   | || ||||.||.||..  ||..||||||| || .  | ||....|. |  ||  . 
sprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 20-293 7.2e-73 238.4 In-house 3-276 (280) alignment 
Range on Protein: 20-293
Range on HMM: 3-276/280.0
CKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHE
|. ..  .. ..    . |. .|||. |  .|. | ||.| |..|.  || . |. |. . .|.|||||||   .| . ||..||.|||.|| .||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGY
.  . ..|||| ||  ||| . .|  |   |. .|...|.  ...|.|||||| .  || || . |  |    | . ||||||| ..| ||  | ||  |
tpsvnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
 ||. . |   ..  . |. ||||.| .||.    | ..|.|| |||| .  | ||.. |.  |. || |. | |
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 20-73 7.3e-13 41.3 In-house 5-59 (317) alignment 
Range on Protein: 20-73
Range on HMM: 5-59/317.0
CKQ-LSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGG
|.. ..|...  || .|.|.. ||    |...|||..||.||||.||. |. . |
cqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 21-291 7.6e-77 251.0 In-house 8-281 (287) alignment 
Range on Protein: 21-291
Range on HMM: 8-281/287.0
KQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHES
. .|.... .. ||..|||   . . ||. |.|..||.|||..||. .|   |..|...|||.|||||||  |.| . || .||..| ... .|||||| 
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

RQITQVYGFYDECLRKYGnANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQE--VPHEGPMCDLLWSDPDDRgGWGIS---PRG
..| ..|||..|  ||..  ...| | |.|..||| | |. .|.|.|||.|| ...|| ..|| . .     .|| . ||||.||.     ..     |.
kkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkira

AGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
    ||.   . . .  .. |. |||... |||..  |...||.|||| |. .  | .|.. ....|. || .. |
isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 21-285 5.4e-59 192.8 In-house 4-293 (302) alignment 
Range on Protein: 21-285
Range on HMM: 4-293/302.0
KQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSP-----------DTNYLFMGDYVDRGYYSVETVTLLVALKVRYRE
|..|.|.. .|.|.  | | ||... |.  |||. ||.||||.||. ..    ..               ..|.|||||||. |.| ..|. |||| |..
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

RITILRGNHESRQITQVYGFYDECLRKYGNAN---VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-LQEVPHEGPMCDLLWSDPDD
.  .||||||.. |   ||| .|   ..|...   .|. | . | ..||.|||  .|.|.|||.|| ...|..|. ..| |.|| ..    |||..|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

RGGWGISPRGAGYTFG--QDISETFNHAN--------GLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYS
  .  . ..   |..   ...| .||.|         .| |. |||| . ||...  |....||||||.|     |. |....|   | |
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 21-285 9e-59 192.1 In-house 5-294 (302) alignment 
Range on Protein: 21-285
Range on HMM: 5-294/302.0
KQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSP-----------DTNYLFMGDYVDRGYYSVETVTLLVALKVRYRE
|..|.|.. .|.|.  | | ||... |.  |||. ||.||||.||. ..    ..               ..|.|||||||. |.| ..|. |||| |..
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

RITILRGNHESRQITQVYGFYDECLRKYGNAN---VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-LQEVPHEGPMCDLLWSDPDD
.  .||||||.. |   ||| .|   ..|...   .|. | . | ..||.|||  .|.|.|||.|| ...|..|. ..| |.|| ..    |||..|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

RGGWGISPRGAGYTFG--QDISETFNHAN--------GLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYS
  .  . ..   |..   ...| .||.|         .| |. |||| . ||...  |....||||||.|     |. |....|   | |
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
PPP_3 23-290 8.9e-120 391.7 In-house 2-270 (271) alignment 
Range on Protein: 23-290
Range on HMM: 2-270/271.0
LSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQ
|||...|.|..|.||||.||||..|.. |||||||.|||..||.|||..||.||.|.|||.|||||||..|.|...||.|||..| .....|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDL-LWSDPDDRGGWGISPRGAGYTFG
|..||||..|.|.|.|...|.|.....|..|||.||.|......||||||||..||.|. |.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

QDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
.|..|.|...| |.|. |||.|..|||. .||..|||.|||||||.|..|..||..|...|...| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 23-294 6.2e-83 271.2 In-house 8-279 (281) alignment 
Range on Protein: 23-294
Range on HMM: 8-279/281.0
LSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQ
... .....  ... |...|... |.  |..| ||.|.||.|| .|| . |. |.. ..|.|||||||  |.|.. || .||.|||.|| .||||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

ITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTFG
. ..|||| ||  |||  ..|  |   |. ||..||.. .. |.|||||| . .||..|   .  . .. | . ||||.|||... .|  | ||...|||
vnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

QDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
... .      .. |. ||||.|..||.    |...|.||.||||    | ||.. .|.||. |.... ||. 
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
subfamily_PPZ_pd Subfamily PPZ 23-291 7.7e-82 268.2 In-house 25-293 (300) alignment 
Range on Protein: 23-291
Range on HMM: 25-293/300.0
LSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQ
| .|..  .| ||.|..  . .. |.  .| . ||||||. ||. ||   |  | .||||.|||||||  |.||. ||.. |..| | . .||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECLRKyGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFG
.|.|||||||| |.  | ..|| | | |. |||.|.| |.|||.|||||| ....| || . |  .||  | . ||||||| |    |    ||  | . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

QDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
.   . |    |. || ||| .| .||..  ||..||.|||||||    |  |.| . . |  ||  .||
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
PPP_1 24-278 7e-118 385.6 In-house 2-264 (264) alignment 
Range on Protein: 24-278
Range on HMM: 2-264/264.0
SESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQI
.|.....|..|.||.|.||.|..||. ..|||||.||||.||..||..||.||.|||||.|||||||..|||...||.|||..|......|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDL--------LWSDPDDRGGWGISPRG
|.||||..|.|.|.......|..||.||.|||.||.|..|...||||||..|.||.|| ..| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL
|||.||.|..|.|...|.|.|. |||....|||.....|.|||||||.||.....|..|...|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PP2Ac_SM00156 24-292 9e-110 359.0 In-house 2-270 (271) alignment 
Range on Protein: 24-292
Range on HMM: 2-270/271.0
SESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQI
|...|..|.|..||||..|.|. ||  ||||.||.|||..||..|.. .|..|...|.|.|||||||..|.|...||.|||..| |....|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDP-DDRGGWGISPRGAGYTFGQ
...|||..|. ||| ...... |...|..|||.|||| .|.|.||||||.. .||.|| |.| .| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPA
|. . | ..| | |. |||..|.|||....|...||||||||||....|.||.......|| |. |....
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 25-73 1.3e-07 24.1 In-house 13-61 (339) alignment 
Range on Protein: 25-73
Range on HMM: 13-61/339.0
ESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGG
 ...  || .|.|..  |  . .. .|. | ||.|||| ||. .. . |
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 26-291 1.6e-72 237.3 In-house 6-273 (284) alignment 
Range on Protein: 26-291
Range on HMM: 6-273/284.0
SQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQ
 .|..|  .| .|. |.  . ||  |. .|||.|||| ||. ||   |    .||||.||||||| . .||. ||.| || . ... .||||||   | .
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

VYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPM-CDLLWSDPDD-RGGWGISPRGAGYTFGQD
.||||.|| |.| .  |.. |  .|  .||||||  .|.|.|||.|  .. . ..||. |  . |    .  |.||||| . . ||    ||  | || |
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

ISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
    .     . || ||||.| .||..  .| .||||||| || .  | ||.| ..  |  ||. . |
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 27-293 1.4e-66 217.7 In-house 24-293 (307) alignment 
Range on Protein: 27-293
Range on HMM: 24-293/307.0
QVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQV
... .  .|. |.. |  . ..  |. | ||.|||| ||...| . |. |.| |.| |||||||  |.|.. ||.. |. | | | .||||||  .. . 
efenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkk

YGFYDECLRKYGN--ANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQD
||||.||.    .   ..|  |   |. ||..||.  .|.|.||||||..  || .|   .    |  | . |.||.|||     |  | ||.|.||| .
ygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtn

ISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
. .   .  |. |. ||||....||     |...|||||| ||    |  ... .|.||    . | |. 
viddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes
subfamily_PPPLV_pd Subfamily PPPLV 29-279 2.9e-53 174.0 In-house 3-276 (290) alignment 
Range on Protein: 29-279
Range on HMM: 3-276/290.0
KSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLM----ELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQIT
 |||..| .|| .| .. |.. |. | ||.||...||.     |.|.| .   ...||.||||||| .||| .. |.|||| |  .. .|||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECLRKYGNA--NVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRAL----DRLQEVPHEGPM-CDLLWSDPDDR-----------
. . .. |.  |.|.   .||. |.. ||.|||.| .| ..|| |.|.  .| |  .| |.    .||..  .  |.  |.|||||..            
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

--GGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRcGNQAAIMELD
  |    . || |. |..|  |.| . |.|  | |||.   .|..  ..  ..|.||. .||    |.||.. .|
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 46-291 4.1e-58 190.1 In-house 3-255 (263) alignment 
Range on Protein: 46-291
Range on HMM: 3-255/263.0
QEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNAN----
 |...|. .||| |||. ||. .|   | .  |.|||.||||||| .|.| . ||..||.    .. .|||||| . | . |||. |  ...   .    
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPM-CDLLWSDPDDrGGWGISP---RGAGYTFGQDISETFNHANGLTLV
|...| ..| |.|| |.|  .|.|.|||.|| . .|| |||.    |  .  |. |||||.||.     |. |   |     ||.   . . .   . |.
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidli

SRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
 ||||.|  || .  || ..|.|||  |     | ||.. ..  |. ||.|. |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
Metallophos Calcineurin-like phosphoesterase 51-243 5.2e-43 140.6 Pfam-A 2-198 (200) alignment 
Range on Protein: 51-243
Range on HMM: 2-198/200.0
PVTVCGDVHGQFHDL----MELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLL--VALKVRYRERITILRGNHESRQITQVYGFYDECL----------
...|.||.||...||    ..|..|..... ...||.||.|||| .| ||  ||   .||...  ..  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIraldrlqevphegpmcdllwsdpddrggwgi
                       ..... ... .. . |..||| |||||.|.. ||.||.| .. | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYTFGQDISETFNHANGLTLVSRAHQL
    ... || |  | .   .|..|| |.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 52-243 2.7e-80 261.7 In-house 1-197 (198) alignment 
Range on Protein: 52-243
Range on HMM: 1-197/198.0
VTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFD
||||||.|||..||..||. |..||...|||.|||||||..|.|...||.|||..|......|||||||.....||||..|.|.|.|...|.|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDL-----LWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQL
.|||.||.|......|||||..|..||.|.  .| .|.|.||...||     |..........  | ||||..||.|..|.. ..| |.|. |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 52-243 8.3e-76 247.4 In-house 1-196 (197) alignment 
Range on Protein: 52-243
Range on HMM: 1-196/197.0
VTVCGDVHGQFHDL-MELFRIGGKSP-DTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKyGNANVWKYFTDL
|||.||.|||..|| ..|...||. . ...|.|.|||||||..|.|...||.|||..| .....|||||||......|||..|.|.|  .....|...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVP-HEGPMCDL-LWSDPD-DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQL
||.|||.||.|......|||||.....||.|....| .|.| .|. ..|| |||||  .  |.  | ||||..||.|. |.| ..|.| |. |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 52-243 5e-75 244.9 In-house 1-198 (199) alignment 
Range on Protein: 52-243
Range on HMM: 1-198/199.0
VTVCGDVHGQFHDL-MELFRIG-GKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDL
||||||.|||..|| ..||. |  .|....|.|.|||||||..|.|...||.|||..| .....||||||..|....|||..|.|.||......|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVP-HEGPMCDL-LWSDPD-DRGG-WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQL
||.|||.||.|......||||||.|..........| .|.| ..| ..|| |||||  .  | .  | ||||..||.|. |.| . |.| |. |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 52-125 2.6e-09 29.9 In-house 12-81 (235) alignment 
Range on Protein: 52-125
Range on HMM: 12-81/235.0
VTVCGDVHGQFHDLMELFR--IGGKSPDTNYLFMGDYVDRGYYSVETVTLLvalkvrYRERITILRGNHESRQITQ
. | ||||| . .|.||.   |||| ..   ...|| ...|  |||.| ..       ..    ..||||   . .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvlla
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 77-292 1.5e-72 237.4 In-house 100-315 (317) alignment 
Range on Protein: 77-292
Range on HMM: 100-315/317.0
DTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDT
  .|||.||||||| .|.| |.||.|||..| .....|||||||| . . |||| |. ..| .|.... |   |  |||.|.|. .|.|.|||.| ..  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAI
|. . .|.|  ..|  | ..|| |.||| .  |.  |.||||  ||..  . |..   | || ||||.|..||..  ||..|||||||.|| .  | ||.
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

MELDDTLKYSFLQFDPA
...|. || |.  . | 
lsvdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 79-294 1.5e-57 188.2 In-house 121-336 (339) alignment 
Range on Protein: 79-294
Range on HMM: 121-336/339.0
NYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLD
 |||.||||||| .|.| | || |||. | .|| .|||||||| .   |||| |   .| .|.... | ..|. .|. |...  |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

HIRALDRLQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIME
..  . |  |.|  | . || |.|||    |.  | ||| . ||     .| .   | .| | ||.| .||..   | .|||||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDDTLKYSFLQFDPAPR
.|  || |   | |  |
idkklkisinvfrpesr
subfamily_PPP7C_pd Subfamily PPP7C 195-292 8.4e-22 70.4 In-house 237-335 (383) alignment 
Range on Protein: 195-292
Range on HMM: 237-335/383.0
MCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPA
. |.|||||   .| .  . ||.|  || |... . .  .|.|. |.|.  .|||...||..|.||||| ||     |. | . | ..|.  ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas