Gene PPP2CB in Homo sapiens

Synonym: PP2Abeta, PP2CB, PPP2CB

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP137_AA protein Get Run
HsapP137_AA_4-295 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 3-293 2.8e-101 331.5 In-house 4-295 (298) alignment 
Range on Protein: 3-293
Range on HMM: 4-295/298.0
DKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVA
|. ... | . ... . .|...|..| .|.|.||.|..| . . ||  |..||||.|||. ||. ||  .|  ||.||||.||||||| ...|...||.|
dellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivllla

LKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSD
 ||.||... .||||||  .| .|||||.|| |.| . .... | |.|. ||||||. |.|.|.|||||. . .||..|.| | .. ..|    ||||.|
ykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwad

PDD-RGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
|..   ||  . ||....||.|  . . .   . || ||||.| .||..  ....|||||||.|| .  | ||.|..|. |. ||  . |. 
penavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
0053225 Metallo-dependent phosphatases 5-293 8.8e-111 362.8 In-house 4-292 (293) alignment 
Range on Protein: 5-293
Range on HMM: 4-292/293.0
AFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALK
 ..  ||...|.|  .|.|.|.....|...||||| ||.|..|.. ...|.||.||...||..|... |  |.....|.||.||||..|.|...|| |||
lilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalk

VRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD
..||.....||||||.......|||.||.|||||.|..|....|....|||.||..|.|.. ||||||....||.|| ..| ...|.||...||||||||
llypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd

DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
.. ||..|.||.|..|| .. . | ..|||.|. |.||.|..|| ...|...||.||||||..|.||..|...||. |...| .|.| .
lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
0049330 Metallo-dependent phosphatases 6-295 5e-115 376.7 In-house 13-302 (309) alignment 
Range on Protein: 6-295
Range on HMM: 13-302/309.0
FTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKV
... ||...|.|  .|.|.|.....|..|||||| .|.|..|.  ...|.||.|||..||..|... |  |.....|.||.||||..|.|...|| |||.
ilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkl

RYPERITILRGNHESRQITQVYGFYDECLRKYGnANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD-
.||.....||||||.|.....|||.||.||||| |..|..|.|....|||.|...|.|.| ||||||.. .||.||.|.| .|.|..|..||||||||. 
lypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplp

DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRR
.| |.. .|||.|..|| .. | | . |||.|. |.|..|..|| ...|....|.|||||||.|.||..|..|.|..|..|||.|.|.|. 
iregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
subfamily_PPP5C_pd Subfamily PPP5C 6-291 7.7e-86 281.0 In-house 16-308 (322) alignment 
Range on Protein: 6-291
Range on HMM: 16-308/322.0
FTKE-LDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCP----VTVCGDVHGQFHDLMELFRIGGK-SPDTNYLFMGDYVDRGYYSVETVTL
 ||| ... .|.... |.|..  . ..  .|||.| |.. . |.. .    .|||||.||||.||...|.. |. |..  ||| ||.|||| .|||.. .
itkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsvevilt

LVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSI-DTLDHIRALDRLQEVPHEGPMCDL
|...|. ||... . |||||| .. ..||| .|.  || ...| . ||..|..|||. ... ... .||||  .   |||..| .|| .. |.|| ...|
llgfkllyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvel

LWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL-DDTLKYSFLQFDP
|||||... | . | || | .|| |... | . |.|.|. |.|.. .|||.  || ...|.||||||| . ||..|...| .| ||  | .|. 
lwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfea
subfamily_PPP2C_pd Subfamily PPP2C 7-296 4.7e-194 636.0 In-house 1-290 (290) alignment 
Range on Protein: 7-296
Range on HMM: 1-290/290.0
TKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVR
.|.||...|.|.|||||.|..|..|||||||||.||||||||.||||||||||||||||.|||.||||||||||||.|||||||||||||||||||||||
ikdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvr

YPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR
|.||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||.|||||||||||||||.|||||||||||
ykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr

GGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRG
|||||||||||||||.||||.||..|||||..||||||||||||.||||||||||||||||||||||||.||||.|||||||||||||||
ggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprrg
0045823 Metallo-dependent phosphatases 8-294 1.7e-121 399.0 In-house 28-326 (473) alignment 
Range on Protein: 8-294
Range on HMM: 28-326/473.0
KELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRY
  ||...|.| ....|.|.... |...||||| ||.|..|.  ...|.||.|||..||..|... |  |.....|.||.||||..|.|.. || |||..|
ldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkiky

PERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRG
|.....||||||.|.....|||.||.|.|| .......| .....|||.|...|.|.. ||||||....|| ||...| .|.|..|...|||||||..  
pgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwedd

G--------WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRN------VVTIFSAPNYCYRCGNQAAIMELDDTLkYSFLQFDPAP
|        .| |||||||.||.|. | | . |||.|. |.|. |.|||....|..      ..|.|||||||.|.|| ||....|..| .|| ||||.|
gdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsp

R
 
h
subfamily_PPP7C_pd Subfamily PPP7C 8-186 3.5e-40 130.9 In-house 18-202 (383) alignment 
Range on Protein: 8-186
Range on HMM: 18-202/383.0
KELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRC----PVTVCGDVHGQFHDLMELF-RIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVA
.|... .|...| |.|  . | ..  .||..| .  |...|       ||||||.||.. ||. .. . |  |.. .|.| ||.||||  ||| . .|.|
deveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillilla

LKVRYPERITILRGNHESRQITQVYGFYDECLRKY--GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDtLDHIRALDRL
| . ||. . . |||||   .   |||  |   ||   .... . . |.| .|||..|.| .|. .|||.| . | |. .  ..| 
lllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkiers
subfamily_PPP4C_pd Subfamily PPP4C 9-293 6.1e-152 497.8 In-house 2-286 (288) alignment 
Range on Protein: 9-293
Range on HMM: 2-286/288.0
ELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYP
.||. .|.|..|. ..|..|..||.||.||| .|||||.| .|||||||.||||.||.|||..||. |.|||||.||.||||.|||||  ||.|||||||
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

ERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGG
.|||..||||||||||||||||||||||||.||||.| |..||||.|.|..||.|||.||||||||.|||.||..|| ||||||||.||||||||.|  |
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
|..||||||| ||.|..|.||.||...|..||||||||||..  ...|.|..||||||||||| |||.|||..|.. |  |. |.
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPP6C_pd Subfamily PPP6C 9-290 5.4e-141 461.8 In-house 1-282 (290) alignment 
Range on Protein: 9-290
Range on HMM: 1-282/290.0
ELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYP
|||.|.|. ..|| |.||... ||.. ...| .||||| |..|||||||.||||.||.|||| ||. |||.|.|.||.|||||||.||.|.|..||..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

ERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGG
.|||.|||||||||||||||||||||.||||||.|||.|..|| |...|..|.|..|.|||||| . |||.|| ..| ||.||.|..|||.||||.|   
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
| .||||||| ||. ... |.| | | |..||||||.||...  | ..||..||||||||||| |.|..|.|. . ..  |.
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_PPG1_pd Subfamily PPG1 10-294 1.7e-132 434.2 In-house 1-298 (300) alignment 
Range on Protein: 10-294
Range on HMM: 1-298/300.0
LDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPE
||. .|.|. .. | |  |. |..| ||.| |||||.|.|.|||| |||||||.|..|.|.|||. |||||||.|||||||.|||||..||..||.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITILRGNHESRQITQVYGFYDECLRKY-GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD----
|||.||||||||||||||||| |||||| ||..||||.|..|||| |.|..| .|.|.|||||||. ..| |. |||..|||.|| ..|||||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DRGG--WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
      || |  . .|.|||||..|.|. | | . | .  . |||||..|||.   |  . |..|||||||||||.|.|.|| . ... |  .. ||.
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
subfamily_PPP3C_pd Subfamily PPP3C 12-280 3.5e-89 292.6 In-house 30-311 (452) alignment 
Range on Protein: 12-280
Range on HMM: 30-311/452.0
QWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERI
   | . .  .|.|...  . |.| ..| ||... ||  |.||.||.||||.||..|| .||.  .|.|||.||||||||.|.|.|  | |||. ||...
vlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstl

TILRGNHESRQITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGI
 .||||||.| .|. . | .||  ||.. .|.. ... || |||.||...| .|.|||||| | .|| |. |||..|.|. ||.|||||||| .. |   
fllrGnhecrhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeek

--------SPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHD------RNVVTIFSAPNYCYRCGNQAAIMELDD
        |.||  | ..   . .| ..| |  . |||.   .||.  ..        ..|.||||||.    |.||......
teekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 19-292 2.5e-88 288.9 In-house 4-275 (280) alignment 
Range on Protein: 19-292
Range on HMM: 4-275/280.0
ECkqLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNH
.|  ..| .. .. || |.||| .. . || .||.||||.|||. ||. ||   .  ||.||||.||||||| . .| . ||.| |||||... ||||||
ac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnh

ESRQITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD-DRGGWGISPRGAG
|  .| . |||.||. |.| . .... | .|.| |||.||| |.|.|.|||||. . .||... | |  . ..|    ||||.||. .  ||. ..||. 
evisinrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

YTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPA
. ||...   . .   . |. | ||.| .||..  |...||.||||.|.    |.||.. .|. |. ||  . ||
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 19-290 3.9e-78 255.7 In-house 19-293 (297) alignment 
Range on Protein: 19-290
Range on HMM: 19-293/297.0
ECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNH
 .| . |..|  | . | ... .. .. || .|. ||||.|||| ||. ||. ||  | .||||.||||||| .|.||. ||.| ||..|  . .|||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSP---SIDTLDHIRALDRLQEVpHEGPMCDLLWSDPD-DRGGWGISPR
|   . .|||||.|| ..|    ..  | |.|..|||| |.  .|.|.||||||      ||| .| ..| .|  .|. ..||||.||     |.    |
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqr

GAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
|||  ||.|          | || ||||.| .||..   |..||||||| || .  | ||.|  |. |. ||  . 
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 19-291 5.1e-69 225.5 In-house 12-288 (290) alignment 
Range on Protein: 19-291
Range on HMM: 12-288/290.0
ECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNH
  . ...... .. ||..|||     . ||  |... ||.|||. .|.. |   |. |. ..||.|||||||  |.|   ||  .|.||.... .|||||
vldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnh

ESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR--LQEVPHEGPMCDLLWSDPDD--RGGWGI-SP
| |.. ..|||..|  ||  ....|| . |.|. |.| | |. .|.|.|||.|. |.. . ..|| .   .   .|| . ||||.||.        .   
evrkvnrlygfkeelarkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkq

RGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
|.    ||..  ... .  .| |. |||..  ||.|.  |...||.|||| |. .  |  ||... ..|. |.  . |
raisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_PPP1C_pd Subfamily PPP1C 20-290 1.4e-107 352.1 In-house 7-277 (282) alignment 
Range on Protein: 20-290
Range on HMM: 7-277/282.0
CKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHE
  .|.|.....|..||.|||.... . |.. ||...||.|||..||. || ..|  |..||||.|||||||  |.||..||.|.|..|||.. .||||||
evklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhe

SRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGY
| .|...||||||| |.|..  .|| ||| |..|||.|||| .|.|.||||||... |..|| . |  |||..| .|||||||||. . ||. . ||  .
sasinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsf

TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
|||.|. |.| . | | |. ||||.| .||..  .|..||.||||||| . .|..|....|..|. ||  . 
tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 20-295 5e-91 298.0 In-house 21-297 (299) alignment 
Range on Protein: 20-295
Range on HMM: 21-297/299.0
CKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHE
 | ..|....|||. ||....... . ||  |. ||||.|||. ||. .| . |  ||.|.||.|||||||   .|..|||.. |..||||. .||||||
tksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhe

SRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGY
   | .|||||.|| ..|  . .|  | | |...||| |. ..|.|.|||||| ..||| .| | | |. |      ||||.|||.   .|    ||  |
cpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsy

TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRR
 ||||. .   .  .. ||.||||.| .||..  ....||||||| || .  | ||||..|. |  .|  . |.|..
vfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 20-290 4.8e-85 278.4 In-house 4-281 (284) alignment 
Range on Protein: 20-290
Range on HMM: 4-281/284.0
CKQ-LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKS------PDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERIT
|.. |.|...  || .|.|.. ||.  .|...||...||.|||| ||. |. . |         ...|||.||||||| .|.| .||| |.|...|....
cqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvf

ILRGNHESRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGI
.|||||||| . . |||| || ..| .| ... |   |  .||.|.|. .|.|.|||.|  .  |. . .|.|  ..|  | ..|| |.||. .  |.  
llrgnhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegyke

SPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
|||||| .||..  . |..   | || ||||.||.||..  ||..||||||| || .  | ||....|. |  ||  . 
sprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 20-293 1.9e-71 233.8 In-house 3-276 (280) alignment 
Range on Protein: 20-293
Range on HMM: 3-276/280.0
CKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHE
|. .   .. ..    . |. .|||. |  .|. | ||.| |..|.  || . |. |. . .|.|||||||   .| . ||..||.|| .|| .||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGY
.  . ..|||| ||  ||| . .|  |   |. .|...|.  ...|.|||||| .  || || . |  |    | . ||||||| ..| ||  | ||  |
tpsvnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
 ||. . |   ..  . |. ||||.| .||.    | ..|.|| |||| .  | ||.. |.  |. || |. | |
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 20-73 5.3e-13 41.8 In-house 5-59 (317) alignment 
Range on Protein: 20-73
Range on HMM: 5-59/317.0
CKQ-LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGG
|.. ..|...  || .|.|.. ||    |...|||..||.||||.||. |. . |
cqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 21-291 9.2e-78 254.0 In-house 8-281 (287) alignment 
Range on Protein: 21-291
Range on HMM: 8-281/287.0
KQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHES
. ...... .. ||..|||   . . ||. |.|..||.|||..||. .|   |..|...|||.|||||||  |.| . || .||..||... .|||||| 
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

RQITQVYGFYDECLRKYGnANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQE--VPHEGPMCDLLWSDPDDRgGWGIS---PRG
..| ..|||..|  ||..  ...| | |.|..||| | |. .|.|.|||.|| ...|| ..|| . .     .|| . ||||.||.     ..     |.
kkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkira

AGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
    ||.   . . .  .. |. |||... |||..  |...||.|||| |. .  | .|.. ....|. || .. |
isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 22-285 2.8e-59 193.8 In-house 5-293 (302) alignment 
Range on Protein: 22-285
Range on HMM: 5-293/302.0
QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSP-----------DTNYLFMGDYVDRGYYSVETVTLLVALKVRYPER
....... .|.|.  | | ||... |.  |||. ||.||||.||. ..    ..               ..|.|||||||. |.| ..|. |||| ||..
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

ITILRGNHESRQITQVYGFYDECLRKYGNAN---VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-LQEVPHEGPMCDLLWSDPDDR
  .||||||.. |   ||| .|   ..|...   .|. | . | ..||.|||  .|.|.|||.|| ...|..|. ..| |.|| ..    |||..|| | 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

GGWGISPRGAGYTFG--QDISETFNHAN--------GLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYS
 .  . ..   |..   ...| .||.|         .| |. |||| . ||...  |....||||||.|     |. |....|   | |
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 22-285 4.7e-59 193.0 In-house 6-294 (302) alignment 
Range on Protein: 22-285
Range on HMM: 6-294/302.0
QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSP-----------DTNYLFMGDYVDRGYYSVETVTLLVALKVRYPER
....... .|.|.  | | ||... |.  |||. ||.||||.||. ..    ..               ..|.|||||||. |.| ..|. |||| ||..
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

ITILRGNHESRQITQVYGFYDECLRKYGNAN---VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-LQEVPHEGPMCDLLWSDPDDR
  .||||||.. |   ||| .|   ..|...   .|. | . | ..||.|||  .|.|.|||.|| ...|..|. ..| |.|| ..    |||..|| | 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

GGWGISPRGAGYTFG--QDISETFNHAN--------GLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYS
 .  . ..   |..   ...| .||.|         .| |. |||| . ||...  |....||||||.|     |. |....|   | |
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
PPP_3 23-290 1.8e-120 394.0 In-house 2-270 (271) alignment 
Range on Protein: 23-290
Range on HMM: 2-270/271.0
LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQ
|.||....|..|.||||.||||..|.. |||||||.|||..||.|||..||.||.|.|||.|||||||..|.|...||.|||..||.....|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDL-LWSDPDDRGGWGISPRGAGYTFG
|..||||..|.|.|.|...|.|.....|..|||.||.|......||||||||..||.|. |.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

QDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
.|..|.|...| |.|. |||.|..|||. .||..|||.|||||||.|..|..||..|...|...| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_PPZ_pd Subfamily PPZ 23-291 4.4e-83 272.2 In-house 25-293 (300) alignment 
Range on Protein: 23-291
Range on HMM: 25-293/300.0
LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQ
|.....  .| ||.|..  . .. |.  .| . ||||||. ||. ||   |  | .||||.|||||||  |.||. ||.. |..||| . .||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECLRKyGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFG
.|.|||||||| |.  | ..|| | | |. |||.|.| |.|||.|||||| ....| || . |  .||  | . ||||||| |    |    ||  | . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

QDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
.   . |    |. || ||| .| .||..  ||..||.|||||||    |  |.| . . |  ||  .||
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 23-294 1.9e-82 269.7 In-house 8-279 (281) alignment 
Range on Protein: 23-294
Range on HMM: 8-279/281.0
LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQ
. .... ..  ... |...|... |.  |..| ||.|.||.|| .|| . |. |.. ..|.|||||||  |.|.. || .||.||..|| .||||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

ITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTFG
. ..|||| ||  |||  ..|  |   |. ||..||.. .. |.|||||| . .||..|   .  . .. | . ||||.|||... .|  | ||...|||
vnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

QDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
... .      .. |. ||||.|..||.    |...|.||.||||    | ||.. .|.||. |.... ||. 
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
PPP_1 24-278 9.2e-119 388.5 In-house 2-264 (264) alignment 
Range on Protein: 24-278
Range on HMM: 2-264/264.0
NENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQI
.|.....|..|.||.|.||.|..||. ..|||||.||||.||..||..||.||.|||||.|||||||..|||...||.|||..||.....|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDL--------LWSDPDDRGGWGISPRG
|.||||..|.|.|.......|..||.||.|||.||.|..|...||||||..|.||.|| ..| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL
|||.||.|..|.|...|.|.|. |||....|||.....|.|||||||.||.....|..|...|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PP2Ac_SM00156 24-292 9.7e-111 362.1 In-house 2-270 (271) alignment 
Range on Protein: 24-292
Range on HMM: 2-270/271.0
NENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQI
....|..|.|..||||..|.|. ||  ||||.||.|||..||..|.. .|..|...|.|.|||||||..|.|...||.|||..|||....|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDP-DDRGGWGISPRGAGYTFGQ
...|||..|. ||| ...... |...|..|||.|||| .|.|.||||||.. .||.|| |.| .| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPA
|. . | ..| | |. |||..|.|||....|...||||||||||....|.||.......|| |. |....
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 25-291 4.9e-74 242.3 In-house 5-273 (284) alignment 
Range on Protein: 25-291
Range on HMM: 5-273/284.0
ENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQIT
 ..| ||  .| .|. |.  . ||  |. .|||.|||| ||. ||   |    .||||.||||||| . .||. ||.| || .|... .||||||   | 
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

QVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPM-CDLLWSDPDD-RGGWGISPRGAGYTFGQ
..||||.|| |.| .  |.. |  .|  .||||||  .|.|.|||.|  .. . ..||. |  . |    .  |.||||| . . ||    ||  | || 
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgs

DISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
|    .     . || ||||.| .||..  .| .||||||| || .  | ||.| ..  |  ||. . |
dalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 27-293 1.7e-67 220.8 In-house 24-293 (307) alignment 
Range on Protein: 27-293
Range on HMM: 24-293/307.0
QVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQV
..  .  .|. |.. |  . ..  |. | ||.|||| ||...| . |. |.| |.| |||||||  |.|.. ||.. |. ||| | .||||||  .. . 
efenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkk

YGFYDECLRKYGN--ANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQD
||||.||.    .   ..|  |   |. ||..||.  .|.|.||||||..  || .|   .    |  | . |.||.|||     |  | ||.|.||| .
ygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtn

ISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
. .   .  |. |. ||||....||     |...|||||| ||    |  ... .|.||    . | |. 
viddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 27-73 2.4e-07 23.2 In-house 15-61 (339) alignment 
Range on Protein: 27-73
Range on HMM: 15-61/339.0
QVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGG
..  || .|.|..  |  . .. .|. | ||.|||| ||. .. . |
elaelchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_PPPLV_pd Subfamily PPPLV 29-279 1.9e-54 177.9 In-house 3-276 (290) alignment 
Range on Protein: 29-279
Range on HMM: 3-276/290.0
RTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLM----ELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQIT
 .||..| .|| .| .. |.. |. | ||.||...||.     |.|.| .   ...||.||||||| .||| .. |.|||| || .. .|||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECLRKYGNA--NVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRAL----DRLQEVPHEGPM-CDLLWSDPDDR-----------
. . .. |.  |.|.   .||. |.. ||.|||.| .| ..|| |.|.  .| |  .| |.    .||..  .  |.  |.|||||..            
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

--GGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRcGNQAAIMELD
  |    . || |. |..|  |.| . |.|  | |||.   .|..  ..  ..|.||. .||    |.||.. .|
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 46-291 3.5e-59 193.6 In-house 3-255 (263) alignment 
Range on Protein: 46-291
Range on HMM: 3-255/263.0
QEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN----
 |...|. .||| |||. ||. .|   | .  |.|||.||||||| .|.| . ||..||.  | .. .|||||| . | . |||. |  ...   .    
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPM-CDLLWSDPDDrGGWGISP---RGAGYTFGQDISETFNHANGLTLV
|...| ..| |.|| |.|  .|.|.|||.|| . .|| |||.    |  .  |. |||||.||.     |. |   |     ||.   . . .   . |.
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidli

SRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
 ||||.|  || .  || ..|.|||  |     | ||.. ..  |. ||.|. |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
Metallophos Calcineurin-like phosphoesterase 51-243 8.7e-44 143.2 Pfam-A 2-198 (200) alignment 
Range on Protein: 51-243
Range on HMM: 2-198/200.0
PVTVCGDVHGQFHDL----MELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLL--VALKVRYPERITILRGNHESRQITQVYGFYDECL----------
...|.||.||...||    ..|..|..... ...||.||.|||| .| ||  ||   .||...| ..  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIraldrlqevphegpmcdllwsdpddrggwgi
                       ..... ... .. . |..||| |||||.|.. ||.||.| .. | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYTFGQDISETFNHANGLTLVSRAHQL
    ... || |  | .   .|..|| |.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 52-243 4.9e-81 264.1 In-house 1-197 (198) alignment 
Range on Protein: 52-243
Range on HMM: 1-197/198.0
VTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFD
||||||.|||..||..||. |..||...|||.|||||||..|.|...||.|||..||.....|||||||.....||||..|.|.|.|...|.|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDL-----LWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQL
.|||.||.|......|||||..|..||.|.  .| .|.|.||...||     |..........  | ||||..||.|..|.. ..| |.|. |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 52-243 1.2e-76 250.1 In-house 1-196 (197) alignment 
Range on Protein: 52-243
Range on HMM: 1-196/197.0
VTVCGDVHGQFHDL-MELFRIGGKSP-DTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKyGNANVWKYFTDL
|||.||.|||..|| ..|...||. . ...|.|.|||||||..|.|...||.|||..||.....|||||||......|||..|.|.|  .....|...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVP-HEGPMCDL-LWSDPD-DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQL
||.|||.||.|......|||||.....||.|....| .|.| .|. ..|| |||||  .  |.  | ||||..||.|. |.| ..|.| |. |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 52-243 7.6e-76 247.5 In-house 1-198 (199) alignment 
Range on Protein: 52-243
Range on HMM: 1-198/199.0
VTVCGDVHGQFHDL-MELFRIG-GKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDL
||||||.|||..|| ..||. |  .|....|.|.|||||||..|.|...||.|||..||.....||||||..|....|||..|.|.||......|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVP-HEGPMCDL-LWSDPD-DRGG-WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQL
||.|||.||.|......||||||.|..........| .|.| ..| ..|| |||||  .  | .  | ||||..||.|. |.| . |.| |. |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 52-125 4.9e-09 29.0 In-house 12-81 (235) alignment 
Range on Protein: 52-125
Range on HMM: 12-81/235.0
VTVCGDVHGQFHDLMELFR--IGGKSPDTNYLFMGDYVDRGYYSVETVTLLvalkvrYPERITILRGNHESRQITQ
. | ||||| . .|.||.   |||| ..   ...|| ...|  |||.| ..        .    ..||||   . .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvlla
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 77-292 8.1e-74 241.6 In-house 100-315 (317) alignment 
Range on Protein: 77-292
Range on HMM: 100-315/317.0
DTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDT
  .|||.||||||| .|.| |.||.|||..||.....|||||||| . . |||| |. ..| .|.... |   |  |||.|.|. .|.|.|||.| ..  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAI
|. . .|.|  ..|  | ..|| |.||| .  |.  |.||||  ||..  . |..   | || ||||.|..||..  ||..|||||||.|| .  | ||.
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

MELDDTLKYSFLQFDPA
...|. || |.  . | 
lsvdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 79-294 1.3e-58 191.7 In-house 121-336 (339) alignment 
Range on Protein: 79-294
Range on HMM: 121-336/339.0
NYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLD
 |||.||||||| .|.| | || |||. ||.|| .|||||||| .   |||| |   .| .|.... | ..|. .|. |...  |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

HIRALDRLQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIME
..  . |  |.|  | . || |.|||    |.  | ||| . ||     .| .   | .| | ||.| .||..   | .|||||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDDTLKYSFLQFDPAPR
.|  || |   | |  |
idkklkisinvfrpesr
subfamily_PPP7C_pd Subfamily PPP7C 195-292 8.9e-22 70.3 In-house 237-335 (383) alignment 
Range on Protein: 195-292
Range on HMM: 237-335/383.0
MCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPA
. |.|||||   .| .  . ||.|  || |... . .  .|.|. |.|.  .|||...||..|.||||| ||     |. | . | ..|.  ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas