Gene PPP2CB in Homo sapiens

Synonym: PP2Abeta, PP2CB, PPP2CB

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP137_AA protein Get Run
HsapP137_AA_4-295 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 3-293 2.8e-101 331.5 In-house 4-295 (298) alignment
Range on Protein: 3-293
Range on HMM: 4-295/298.0
DKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVA
|. ... | . ... . .|...|..| .|.|.||.|..| . . ||  |..||||.|||. ||. ||  .|  ||.||||.||||||| ...|...||.|
dellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivllla

LKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSD
 ||.||... .||||||  .| .|||||.|| |.| . .... | |.|. ||||||. |.|.|.|||||. . .||..|.| | .. ..|    ||||.|
ykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwad

PDD-RGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
|..   ||  . ||....||.|  . . .   . || ||||.| .||..  ....|||||||.|| .  | ||.|..|. |. ||  . |. 
penavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek

0053225 Metallo-dependent phosphatases 5-293 8.8e-111 362.8 In-house 4-292 (293) alignment
Range on Protein: 5-293
Range on HMM: 4-292/293.0
AFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALK
 ..  ||...|.|  .|.|.|.....|...||||| ||.|..|.. ...|.||.||...||..|... |  |.....|.||.||||..|.|...|| |||
lilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalk

VRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD
..||.....||||||.......|||.||.|||||.|..|....|....|||.||..|.|.. ||||||....||.|| ..| ...|.||...||||||||
llypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd

DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
.. ||..|.||.|..|| .. . | ..|||.|. |.||.|..|| ...|...||.||||||..|.||..|...||. |...| .|.| .
lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl

0049330 Metallo-dependent phosphatases 6-295 5e-115 376.7 In-house 13-302 (309) alignment
Range on Protein: 6-295
Range on HMM: 13-302/309.0
FTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKV
... ||...|.|  .|.|.|.....|..|||||| .|.|..|.  ...|.||.|||..||..|... |  |.....|.||.||||..|.|...|| |||.
ilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkl

RYPERITILRGNHESRQITQVYGFYDECLRKYGnANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD-
.||.....||||||.|.....|||.||.||||| |..|..|.|....|||.|...|.|.| ||||||.. .||.||.|.| .|.|..|..||||||||. 
lypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplp

DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRR
.| |.. .|||.|..|| .. | | . |||.|. |.|..|..|| ...|....|.|||||||.|.||..|..|.|..|..|||.|.|.|. 
iregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll

subfamily_PPP5C_pd Subfamily PPP5C 6-291 7.7e-86 281.0 In-house 16-308 (322) alignment
Range on Protein: 6-291
Range on HMM: 16-308/322.0
FTKE-LDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCP----VTVCGDVHGQFHDLMELFRIGGK-SPDTNYLFMGDYVDRGYYSVETVTL
 ||| ... .|.... |.|..  . ..  .|||.| |.. . |.. .    .|||||.||||.||...|.. |. |..  ||| ||.|||| .|||.. .
itkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsvevilt

LVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSI-DTLDHIRALDRLQEVPHEGPMCDL
|...|. ||... . |||||| .. ..||| .|.  || ...| . ||..|..|||. ... ... .||||  .   |||..| .|| .. |.|| ...|
llgfkllyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvel

LWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL-DDTLKYSFLQFDP
|||||... | . | || | .|| |... | . |.|.|. |.|.. .|||.  || ...|.||||||| . ||..|...| .| ||  | .|. 
lwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfea

subfamily_PPP2C_pd Subfamily PPP2C 7-296 4.7e-194 636.0 In-house 1-290 (290) alignment
Range on Protein: 7-296
Range on HMM: 1-290/290.0
TKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVR
.|.||...|.|.|||||.|..|..|||||||||.||||||||.||||||||||||||||.|||.||||||||||||.|||||||||||||||||||||||
ikdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvr

YPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR
|.||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||.|||||||||||||||.|||||||||||
ykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr

GGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRG
|||||||||||||||.||||.||..|||||..||||||||||||.||||||||||||||||||||||||.||||.|||||||||||||||
ggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprrg

0045823 Metallo-dependent phosphatases 8-294 1.7e-121 399.0 In-house 28-326 (473) alignment
Range on Protein: 8-294
Range on HMM: 28-326/473.0
KELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRY
  ||...|.| ....|.|.... |...||||| ||.|..|.  ...|.||.|||..||..|... |  |.....|.||.||||..|.|.. || |||..|
ldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkiky

PERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRG
|.....||||||.|.....|||.||.|.|| .......| .....|||.|...|.|.. ||||||....|| ||...| .|.|..|...|||||||..  
pgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwedd

G--------WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRN------VVTIFSAPNYCYRCGNQAAIMELDDTLkYSFLQFDPAP
|        .| |||||||.||.|. | | . |||.|. |.|. |.|||....|..      ..|.|||||||.|.|| ||....|..| .|| ||||.|
gdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsp

R
 
h

subfamily_PPP7C_pd Subfamily PPP7C 8-186 3.5e-40 130.9 In-house 18-202 (383) alignment
Range on Protein: 8-186
Range on HMM: 18-202/383.0
KELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRC----PVTVCGDVHGQFHDLMELF-RIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVA
.|... .|...| |.|  . | ..  .||..| .  |...|       ||||||.||.. ||. .. . |  |.. .|.| ||.||||  ||| . .|.|
deveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillilla

LKVRYPERITILRGNHESRQITQVYGFYDECLRKY--GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDtLDHIRALDRL
| . ||. . . |||||   .   |||  |   ||   .... . . |.| .|||..|.| .|. .|||.| . | |. .  ..| 
lllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkiers

subfamily_PPP4C_pd Subfamily PPP4C 9-293 6.1e-152 497.8 In-house 2-286 (288) alignment
Range on Protein: 9-293
Range on HMM: 2-286/288.0
ELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYP
.||. .|.|..|. ..|..|..||.||.||| .|||||.| .|||||||.||||.||.|||..||. |.|||||.||.||||.|||||  ||.|||||||
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

ERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGG
.|||..||||||||||||||||||||||||.||||.| |..||||.|.|..||.|||.||||||||.|||.||..|| ||||||||.||||||||.|  |
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
|..||||||| ||.|..|.||.||...|..||||||||||..  ...|.|..||||||||||| |||.|||..|.. |  |. |.
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa

subfamily_PPP6C_pd Subfamily PPP6C 9-290 5.4e-141 461.8 In-house 1-282 (290) alignment
Range on Protein: 9-290
Range on HMM: 1-282/290.0
ELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYP
|||.|.|. ..|| |.||... ||.. ...| .||||| |..|||||||.||||.||.|||| ||. |||.|.|.||.|||||||.||.|.|..||..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

ERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGG
.|||.|||||||||||||||||||||.||||||.|||.|..|| |...|..|.|..|.|||||| . |||.|| ..| ||.||.|..|||.||||.|   
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
| .||||||| ||. ... |.| | | |..||||||.||...  | ..||..||||||||||| |.|..|.|. . ..  |.
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk

subfamily_PPG1_pd Subfamily PPG1 10-294 1.7e-132 434.2 In-house 1-298 (300) alignment
Range on Protein: 10-294
Range on HMM: 1-298/300.0
LDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPE
||. .|.|. .. | |  |. |..| ||.| |||||.|.|.|||| |||||||.|..|.|.|||. |||||||.|||||||.|||||..||..||.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITILRGNHESRQITQVYGFYDECLRKY-GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD----
|||.||||||||||||||||| |||||| ||..||||.|..|||| |.|..| .|.|.|||||||. ..| |. |||..|||.|| ..|||||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DRGG--WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
      || |  . .|.|||||..|.|. | | . | .  . |||||..|||.   |  . |..|||||||||||.|.|.|| . ... |  .. ||.
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape

subfamily_PPP3C_pd Subfamily PPP3C 12-280 3.5e-89 292.6 In-house 30-311 (452) alignment
Range on Protein: 12-280
Range on HMM: 30-311/452.0
QWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERI
   | . .  .|.|...  . |.| ..| ||... ||  |.||.||.||||.||..|| .||.  .|.|||.||||||||.|.|.|  | |||. ||...
vlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstl

TILRGNHESRQITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGI
 .||||||.| .|. . | .||  ||.. .|.. ... || |||.||...| .|.|||||| | .|| |. |||..|.|. ||.|||||||| .. |   
fllrGnhecrhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeek

--------SPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHD------RNVVTIFSAPNYCYRCGNQAAIMELDD
        |.||  | ..   . .| ..| |  . |||.   .||.  ..        ..|.||||||.    |.||......
teekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 19-292 2.5e-88 288.9 In-house 4-275 (280) alignment
Range on Protein: 19-292
Range on HMM: 4-275/280.0
ECkqLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNH
.|  ..| .. .. || |.||| .. . || .||.||||.|||. ||. ||   .  ||.||||.||||||| . .| . ||.| |||||... ||||||
ac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnh

ESRQITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD-DRGGWGISPRGAG
|  .| . |||.||. |.| . .... | .|.| |||.||| |.|.|.|||||. . .||... | |  . ..|    ||||.||. .  ||. ..||. 
evisinrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

YTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPA
. ||...   . .   . |. | ||.| .||..  |...||.||||.|.    |.||.. .|. |. ||  . ||
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 19-290 3.9e-78 255.7 In-house 19-293 (297) alignment
Range on Protein: 19-290
Range on HMM: 19-293/297.0
ECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNH
 .| . |..|  | . | ... .. .. || .|. ||||.|||| ||. ||. ||  | .||||.||||||| .|.||. ||.| ||..|  . .|||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSP---SIDTLDHIRALDRLQEVpHEGPMCDLLWSDPD-DRGGWGISPR
|   . .|||||.|| ..|    ..  | |.|..|||| |.  .|.|.||||||      ||| .| ..| .|  .|. ..||||.||     |.    |
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqr

GAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
|||  ||.|          | || ||||.| .||..   |..||||||| || .  | ||.|  |. |. ||  . 
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 19-291 5.1e-69 225.5 In-house 12-288 (290) alignment
Range on Protein: 19-291
Range on HMM: 12-288/290.0
ECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNH
  . ...... .. ||..|||     . ||  |... ||.|||. .|.. |   |. |. ..||.|||||||  |.|   ||  .|.||.... .|||||
vldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnh

ESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR--LQEVPHEGPMCDLLWSDPDD--RGGWGI-SP
| |.. ..|||..|  ||  ....|| . |.|. |.| | |. .|.|.|||.|. |.. . ..|| .   .   .|| . ||||.||.        .   
evrkvnrlygfkeelarkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkq

RGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
|.    ||..  ... .  .| |. |||..  ||.|.  |...||.|||| |. .  |  ||... ..|. |.  . |
raisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp

subfamily_PPP1C_pd Subfamily PPP1C 20-290 1.4e-107 352.1 In-house 7-277 (282) alignment
Range on Protein: 20-290
Range on HMM: 7-277/282.0
CKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHE
  .|.|.....|..||.|||.... . |.. ||...||.|||..||. || ..|  |..||||.|||||||  |.||..||.|.|..|||.. .||||||
evklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhe

SRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGY
| .|...||||||| |.|..  .|| ||| |..|||.|||| .|.|.||||||... |..|| . |  |||..| .|||||||||. . ||. . ||  .
sasinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsf

TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
|||.|. |.| . | | |. ||||.| .||..  .|..||.||||||| . .|..|....|..|. ||  . 
tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 20-295 5e-91 298.0 In-house 21-297 (299) alignment
Range on Protein: 20-295
Range on HMM: 21-297/299.0
CKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHE
 | ..|....|||. ||....... . ||  |. ||||.|||. ||. .| . |  ||.|.||.|||||||   .|..|||.. |..||||. .||||||
tksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhe

SRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGY
   | .|||||.|| ..|  . .|  | | |...||| |. ..|.|.|||||| ..||| .| | | |. |      ||||.|||.   .|    ||  |
cpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsy

TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRR
 ||||. .   .  .. ||.||||.| .||..  ....||||||| || .  | ||||..|. |  .|  . |.|..
vfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 20-290 4.8e-85 278.4 In-house 4-281 (284) alignment
Range on Protein: 20-290
Range on HMM: 4-281/284.0
CKQ-LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKS------PDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERIT
|.. |.|...  || .|.|.. ||.  .|...||...||.|||| ||. |. . |         ...|||.||||||| .|.| .||| |.|...|....
cqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvf

ILRGNHESRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGI
.|||||||| . . |||| || ..| .| ... |   |  .||.|.|. .|.|.|||.|  .  |. . .|.|  ..|  | ..|| |.||. .  |.  
llrgnhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegyke

SPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
|||||| .||..  . |..   | || ||||.||.||..  ||..||||||| || .  | ||....|. |  ||  . 
sprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 20-293 1.9e-71 233.8 In-house 3-276 (280) alignment
Range on Protein: 20-293
Range on HMM: 3-276/280.0
CKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHE
|. .   .. ..    . |. .|||. |  .|. | ||.| |..|.  || . |. |. . .|.|||||||   .| . ||..||.|| .|| .||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGY
.  . ..|||| ||  ||| . .|  |   |. .|...|.  ...|.|||||| .  || || . |  |    | . ||||||| ..| ||  | ||  |
tpsvnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
 ||. . |   ..  . |. ||||.| .||.    | ..|.|| |||| .  | ||.. |.  |. || |. | |
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 20-73 5.3e-13 41.8 In-house 5-59 (317) alignment
Range on Protein: 20-73
Range on HMM: 5-59/317.0
CKQ-LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGG
|.. ..|...  || .|.|.. ||    |...|||..||.||||.||. |. . |
cqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 21-291 9.2e-78 254.0 In-house 8-281 (287) alignment
Range on Protein: 21-291
Range on HMM: 8-281/287.0
KQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHES
. ...... .. ||..|||   . . ||. |.|..||.|||..||. .|   |..|...|||.|||||||  |.| . || .||..||... .|||||| 
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

RQITQVYGFYDECLRKYGnANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQE--VPHEGPMCDLLWSDPDDRgGWGIS---PRG
..| ..|||..|  ||..  ...| | |.|..||| | |. .|.|.|||.|| ...|| ..|| . .     .|| . ||||.||.     ..     |.
kkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkira

AGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
    ||.   . . .  .. |. |||... |||..  |...||.|||| |. .  | .|.. ....|. || .. |
isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 22-285 2.8e-59 193.8 In-house 5-293 (302) alignment
Range on Protein: 22-285
Range on HMM: 5-293/302.0
QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSP-----------DTNYLFMGDYVDRGYYSVETVTLLVALKVRYPER
....... .|.|.  | | ||... |.  |||. ||.||||.||. ..    ..               ..|.|||||||. |.| ..|. |||| ||..
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

ITILRGNHESRQITQVYGFYDECLRKYGNAN---VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-LQEVPHEGPMCDLLWSDPDDR
  .||||||.. |   ||| .|   ..|...   .|. | . | ..||.|||  .|.|.|||.|| ...|..|. ..| |.|| ..    |||..|| | 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

GGWGISPRGAGYTFG--QDISETFNHAN--------GLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYS
 .  . ..   |..   ...| .||.|         .| |. |||| . ||...  |....||||||.|     |. |....|   | |
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 22-285 4.7e-59 193.0 In-house 6-294 (302) alignment
Range on Protein: 22-285
Range on HMM: 6-294/302.0
QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSP-----------DTNYLFMGDYVDRGYYSVETVTLLVALKVRYPER
....... .|.|.  | | ||... |.  |||. ||.||||.||. ..    ..               ..|.|||||||. |.| ..|. |||| ||..
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

ITILRGNHESRQITQVYGFYDECLRKYGNAN---VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-LQEVPHEGPMCDLLWSDPDDR
  .||||||.. |   ||| .|   ..|...   .|. | . | ..||.|||  .|.|.|||.|| ...|..|. ..| |.|| ..    |||..|| | 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

GGWGISPRGAGYTFG--QDISETFNHAN--------GLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYS
 .  . ..   |..   ...| .||.|         .| |. |||| . ||...  |....||||||.|     |. |....|   | |
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls

PPP_3 23-290 1.8e-120 394.0 In-house 2-270 (271) alignment
Range on Protein: 23-290
Range on HMM: 2-270/271.0
LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQ
|.||....|..|.||||.||||..|.. |||||||.|||..||.|||..||.||.|.|||.|||||||..|.|...||.|||..||.....|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDL-LWSDPDDRGGWGISPRGAGYTFG
|..||||..|.|.|.|...|.|.....|..|||.||.|......||||||||..||.|. |.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

QDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD
.|..|.|...| |.|. |||.|..|||. .||..|||.|||||||.|..|..||..|...|...| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle

subfamily_PPZ_pd Subfamily PPZ 23-291 4.4e-83 272.2 In-house 25-293 (300) alignment
Range on Protein: 23-291
Range on HMM: 25-293/300.0
LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQ
|.....  .| ||.|..  . .. |.  .| . ||||||. ||. ||   |  | .||||.|||||||  |.||. ||.. |..||| . .||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECLRKyGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFG
.|.|||||||| |.  | ..|| | | |. |||.|.| |.|||.|||||| ....| || . |  .||  | . ||||||| |    |    ||  | . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

QDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
.   . |    |. || ||| .| .||..  ||..||.|||||||    |  |.| . . |  ||  .||
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 23-294 1.9e-82 269.7 In-house 8-279 (281) alignment
Range on Protein: 23-294
Range on HMM: 8-279/281.0
LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQ
. .... ..  ... |...|... |.  |..| ||.|.||.|| .|| . |. |.. ..|.|||||||  |.|.. || .||.||..|| .||||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

ITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTFG
. ..|||| ||  |||  ..|  |   |. ||..||.. .. |.|||||| . .||..|   .  . .. | . ||||.|||... .|  | ||...|||
vnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

QDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
... .      .. |. ||||.|..||.    |...|.||.||||    | ||.. .|.||. |.... ||. 
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase

PPP_1 24-278 9.2e-119 388.5 In-house 2-264 (264) alignment
Range on Protein: 24-278
Range on HMM: 2-264/264.0
NENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQI
.|.....|..|.||.|.||.|..||. ..|||||.||||.||..||..||.||.|||||.|||||||..|||...||.|||..||.....|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDL--------LWSDPDDRGGWGISPRG
|.||||..|.|.|.......|..||.||.|||.||.|..|...||||||..|.||.|| ..| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL
|||.||.|..|.|...|.|.|. |||....|||.....|.|||||||.||.....|..|...|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl

PP2Ac_SM00156 24-292 9.7e-111 362.1 In-house 2-270 (271) alignment
Range on Protein: 24-292
Range on HMM: 2-270/271.0
NENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQI
....|..|.|..||||..|.|. ||  ||||.||.|||..||..|.. .|..|...|.|.|||||||..|.|...||.|||..|||....|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDP-DDRGGWGISPRGAGYTFGQ
...|||..|. ||| ...... |...|..|||.|||| .|.|.||||||.. .||.|| |.| .| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPA
|. . | ..| | |. |||..|.|||....|...||||||||||....|.||.......|| |. |....
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 25-291 4.9e-74 242.3 In-house 5-273 (284) alignment
Range on Protein: 25-291
Range on HMM: 5-273/284.0
ENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQIT
 ..| ||  .| .|. |.  . ||  |. .|||.|||| ||. ||   |    .||||.||||||| . .||. ||.| || .|... .||||||   | 
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

QVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPM-CDLLWSDPDD-RGGWGISPRGAGYTFGQ
..||||.|| |.| .  |.. |  .|  .||||||  .|.|.|||.|  .. . ..||. |  . |    .  |.||||| . . ||    ||  | || 
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgs

DISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
|    .     . || ||||.| .||..  .| .||||||| || .  | ||.| ..  |  ||. . |
dalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 27-293 1.7e-67 220.8 In-house 24-293 (307) alignment
Range on Protein: 27-293
Range on HMM: 24-293/307.0
QVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQV
..  .  .|. |.. |  . ..  |. | ||.|||| ||...| . |. |.| |.| |||||||  |.|.. ||.. |. ||| | .||||||  .. . 
efenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkk

YGFYDECLRKYGN--ANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQD
||||.||.    .   ..|  |   |. ||..||.  .|.|.||||||..  || .|   .    |  | . |.||.|||     |  | ||.|.||| .
ygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtn

ISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
. .   .  |. |. ||||....||     |...|||||| ||    |  ... .|.||    . | |. 
viddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 27-73 2.4e-07 23.2 In-house 15-61 (339) alignment
Range on Protein: 27-73
Range on HMM: 15-61/339.0
QVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGG
..  || .|.|..  |  . .. .|. | ||.|||| ||. .. . |
elaelchrareliwsepiflkleapicvmgdihgqfddllamldmng

subfamily_PPPLV_pd Subfamily PPPLV 29-279 1.9e-54 177.9 In-house 3-276 (290) alignment
Range on Protein: 29-279
Range on HMM: 3-276/290.0
RTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLM----ELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQIT
 .||..| .|| .| .. |.. |. | ||.||...||.     |.|.| .   ...||.||||||| .||| .. |.|||| || .. .|||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECLRKYGNA--NVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRAL----DRLQEVPHEGPM-CDLLWSDPDDR-----------
. . .. |.  |.|.   .||. |.. ||.|||.| .| ..|| |.|.  .| |  .| |.    .||..  .  |.  |.|||||..            
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

--GGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRcGNQAAIMELD
  |    . || |. |..|  |.| . |.|  | |||.   .|..  ..  ..|.||. .||    |.||.. .|
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvd

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 46-291 3.5e-59 193.6 In-house 3-255 (263) alignment
Range on Protein: 46-291
Range on HMM: 3-255/263.0
QEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN----
 |...|. .||| |||. ||. .|   | .  |.|||.||||||| .|.| . ||..||.  | .. .|||||| . | . |||. |  ...   .    
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPM-CDLLWSDPDDrGGWGISP---RGAGYTFGQDISETFNHANGLTLV
|...| ..| |.|| |.|  .|.|.|||.|| . .|| |||.    |  .  |. |||||.||.     |. |   |     ||.   . . .   . |.
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidli

SRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP
 ||||.|  || .  || ..|.|||  |     | ||.. ..  |. ||.|. |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp

Metallophos Calcineurin-like phosphoesterase 51-243 8.7e-44 143.2 Pfam-A 2-198 (200) alignment
Range on Protein: 51-243
Range on HMM: 2-198/200.0
PVTVCGDVHGQFHDL----MELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLL--VALKVRYPERITILRGNHESRQITQVYGFYDECL----------
...|.||.||...||    ..|..|..... ...||.||.|||| .| ||  ||   .||...| ..  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIraldrlqevphegpmcdllwsdpddrggwgi
                       ..... ... .. . |..||| |||||.|.. ||.||.| .. | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYTFGQDISETFNHANGLTLVSRAHQL
    ... || |  | .   .|..|| |.|. 
....gselfgpdalekllekygvdlvlrGHtH

PPP_2 52-243 4.9e-81 264.1 In-house 1-197 (198) alignment
Range on Protein: 52-243
Range on HMM: 1-197/198.0
VTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFD
||||||.|||..||..||. |..||...|||.|||||||..|.|...||.|||..||.....|||||||.....||||..|.|.|.|...|.|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDL-----LWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQL
.|||.||.|......|||||..|..||.|.  .| .|.|.||...||     |..........  | ||||..||.|..|.. ..| |.|. |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev

PPP_4 52-243 1.2e-76 250.1 In-house 1-196 (197) alignment
Range on Protein: 52-243
Range on HMM: 1-196/197.0
VTVCGDVHGQFHDL-MELFRIGGKSP-DTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKyGNANVWKYFTDL
|||.||.|||..|| ..|...||. . ...|.|.|||||||..|.|...||.|||..||.....|||||||......|||..|.|.|  .....|...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVP-HEGPMCDL-LWSDPD-DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQL
||.|||.||.|......|||||.....||.|....| .|.| .|. ..|| |||||  .  |.  | ||||..||.|. |.| ..|.| |. |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel

PPP_5_Dcr2 52-243 7.6e-76 247.5 In-house 1-198 (199) alignment
Range on Protein: 52-243
Range on HMM: 1-198/199.0
VTVCGDVHGQFHDL-MELFRIG-GKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDL
||||||.|||..|| ..||. |  .|....|.|.|||||||..|.|...||.|||..||.....||||||..|....|||..|.|.||......|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVP-HEGPMCDL-LWSDPD-DRGG-WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQL
||.|||.||.|......||||||.|..........| .|.| ..| ..|| |||||  .  | .  | ||||..||.|. |.| . |.| |. |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel

subfamily_YNL217W_pd Subfamily YNL217W 52-125 4.9e-09 29.0 In-house 12-81 (235) alignment
Range on Protein: 52-125
Range on HMM: 12-81/235.0
VTVCGDVHGQFHDLMELFR--IGGKSPDTNYLFMGDYVDRGYYSVETVTLLvalkvrYPERITILRGNHESRQITQ
. | ||||| . .|.||.   |||| ..   ...|| ...|  |||.| ..        .    ..||||   . .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvlla

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 77-292 8.1e-74 241.6 In-house 100-315 (317) alignment
Range on Protein: 77-292
Range on HMM: 100-315/317.0
DTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDT
  .|||.||||||| .|.| |.||.|||..||.....|||||||| . . |||| |. ..| .|.... |   |  |||.|.|. .|.|.|||.| ..  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAI
|. . .|.|  ..|  | ..|| |.||| .  |.  |.||||  ||..  . |..   | || ||||.|..||..  ||..|||||||.|| .  | ||.
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

MELDDTLKYSFLQFDPA
...|. || |.  . | 
lsvdkklkisinvlrpe

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 79-294 1.3e-58 191.7 In-house 121-336 (339) alignment
Range on Protein: 79-294
Range on HMM: 121-336/339.0
NYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLD
 |||.||||||| .|.| | || |||. ||.|| .|||||||| .   |||| |   .| .|.... | ..|. .|. |...  |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

HIRALDRLQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIME
..  . |  |.|  | . || |.|||    |.  | ||| . ||     .| .   | .| | ||.| .||..   | .|||||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDDTLKYSFLQFDPAPR
.|  || |   | |  |
idkklkisinvfrpesr

subfamily_PPP7C_pd Subfamily PPP7C 195-292 8.9e-22 70.3 In-house 237-335 (383) alignment
Range on Protein: 195-292
Range on HMM: 237-335/383.0
MCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPA
. |.|||||   .| .  . ||.|  || |... . .  .|.|. |.|.  .|||...||..|.||||| ||     |. | . | ..|.  ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas