Gene PPP5C in Homo sapiens

Synonym: PP5, PPP5, PPT, PPP5C

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP5C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP142_AA protein Get Run
HsapP142_AA_166-496 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
TPR_11 TPR repeat 27-93 3.9e-21 64.1 Pfam-A 2-69 (69) alignment 
Range on Protein: 27-93
Range on HMM: 2-69/69.0
RAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTE-CYGYALGDATRAIELDK
.||.|| ..| .||..||..||..|..|.||.|.||..| |..||||.    |  || |...|.|||.
nAealkelGnalfkegdydeAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_2 Tetratricopeptide repeat 28-61 3.5e-10 28.9 Pfam-A 1-34 (34) alignment 
Range on Protein: 28-61
Range on HMM: 1-34/34.0
AEELKTQANDYFKAKDYENAIKFYSQAIELNPSN
|| |  ... |.|..||| |.... .|.||.| |
aealynlGlayyklgdyeeAleafekAleldPnn
TPR_1 Tetratricopeptide repeat 29-61 1.6e-11 33.0 Pfam-A 2-34 (34) alignment 
Range on Protein: 29-61
Range on HMM: 2-34/34.0
EELKTQANDYFKAKDYENAIKFYSQAIELNPSN
. |.  .| |.| ..|. |...|..|.||||.|
kalynlGnaylklgkydeAleyyekALelnPnn
TPR_16 Tetratricopeptide repeat 34-97 1.8e-09 27.7 Pfam-A 3-59 (65) alignment 
Range on Protein: 34-97
Range on HMM: 3-59/65.0
QANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTecygyalGDATRAIELDKKYIK
.|.....|.||. |.. ...|..|.| .| .. ..  |.||        |.  .|..|......
lArallraGdydeAlaaleaalalaPeaaeallllaeallrq.......grldaAaallraala
TPR_8 Tetratricopeptide repeat 38-60 9.5e-06 14.8 Pfam-A 11-33 (34) alignment 
Range on Protein: 38-60
Range on HMM: 11-33/34.0
YFKAKDYENAIKFYSQAIELNPS
|.. .||..|.... .|.||.| 
YrqlGdydkAkeylekalelkpr
Apc3 Anaphase-promoting complex, cyclosome, subunit 3 42-120 8.9e-07 17.5 Pfam-A 3-82 (84) alignment 
Range on Protein: 42-120
Range on HMM: 3-82/84.0
KDYENAIKFYSQAIELNPS--NAIYYGNRSLAYLRTECYGYALGDATRaIELDKKYIKGYYRRAASNMALGKFRAALRDYE
..|.||.... ......|.  .. |. .  |...... |  |.   ..  |||.. ..  |  | .  .|||.  |.. .|
hnyknAlflaekllaespkdpedaylyalAlclylngeykrAyellrk.leldesslgcryllArcllklgkydeAiavLe
TPR_17 Tetratricopeptide repeat 50-75 4.3e-06 16.4 Pfam-A 1-26 (34) alignment 
Range on Protein: 50-75
Range on HMM: 1-26/34.0
FYSQAIELNPSNAIYYGNRSLAYLRT
.| .|.|||| || .| |. ...|. 
lyekalelnPnnadaynnLAelllnn
TPR_11 TPR repeat 81-127 1.9e-10 29.9 Pfam-A 22-69 (69) alignment 
Range on Protein: 81-127
Range on HMM: 22-69/69.0
ALGDATRAIELDKKYIKGYYRRAASNMALG-KFRAALRDYETVVKVKP
|.   ..|.|||... . ||..|.. . || ....||.||| ...  |
AieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_1 Tetratricopeptide repeat 97-129 4.1e-08 22.3 Pfam-A 2-34 (34) alignment 
Range on Protein: 97-129
Range on HMM: 2-34/34.0
KGYYRRAASNMALGKFRAALRDYETVVKVKPHD
| .|....  . |||.  || .|| .... |..
kalynlGnaylklgkydeAleyyekALelnPnn
TPR_2 Tetratricopeptide repeat 97-129 1.4e-06 17.7 Pfam-A 2-34 (34) alignment 
Range on Protein: 97-129
Range on HMM: 2-34/34.0
KGYYRRAASNMALGKFRAALRDYETVVKVKPHD
...|... . ..||..  ||...| ...  |..
ealynlGlayyklgdyeeAleafekAleldPnn
TPR_16 Tetratricopeptide repeat 100-143 4.5e-06 16.9 Pfam-A 1-44 (65) alignment 
Range on Protein: 100-143
Range on HMM: 1-44/65.0
YRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIV
...| . ...|....||. .|....  |.. .|.. . |.    
lalArallraGdydeAlaaleaalalaPeaaeallllaeallrq
PPP5 PPP5 TPR repeat region 135-228 2.3e-43 136.6 Pfam-A 1-94 (95) alignment 
Range on Protein: 135-228
Range on HMM: 1-94/95.0
KYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVE
|..||.|.||..|||.||. ||.||||..|.||||..|||.|.||.|||.|||. |.|||....|.|||||.|..||||..|||.|.||..|||
KlkeCeklvkkiaFekAIevdeekrsvaesidiesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpslve
0045823 Metallo-dependent phosphatases 167-496 3e-112 368.6 In-house 7-341 (473) alignment 
Range on Protein: 167-496
Range on HMM: 7-341/473.0
IESMTIEDEYSGPKLEDGKvTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLketeKITVCGDTHGQFYDLLNIFELNGLPSEtNPY
.  ... . ...|.| . . .......|....| ...|. ......| ..||.|.| ..|.| .     .|.|.|| |||..|||...|..|.|.| . .
lvlipvlrlltlpllfill.glldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drl

IFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDgVTLDDI
.|.||.||||..|.||.. |. .|..||....|||||||. ..|..||| .|. .||....|| | |....||||  |.||.|..||||...   .||.|
vflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdl.plldqi

RKIERNRQPPDSGPMCDLLWSDPQPQNG--------RSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGR------CVTVFSAPNYC
|.||| ...||.|...|||||||....|        .  |.||....||||... ||..|.||.|.|.|..  ||||. ..|.      ..|||||||||
reierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYc

DQMGNKASYIHLQGsDLrPQFHQFTAVPHPNVKPMAYANTLLQL
...||.|..... . || ..|.|| ..|||...|... ..||.|
grggnlaAvlvide.dl.isfiqfdpsphplilplfldvfllsl
subfamily_PPP5C_pd Subfamily PPP5C 171-492 2e-184 604.9 In-house 1-322 (322) alignment 
Range on Protein: 171-492
Range on HMM: 1-322/322.0
TIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNG
|.||.|.|||||..|.|..|.|||....|.|||||.|.|..||...||.|.||..|||.|..||.|.|||||.|||||||||||||||||||.|||.|||
tvedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnG

DFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIE
||||||||||||||||.|||||||.||.| |||||.||||..||||||||||||.....||.|||.|||||..|| |||..||||||||||||||.|||.
dfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkid

RNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLR
||.|||..| ...|||||||..|||| |||||..|||||||| ||.||||..||||||||.|||||.| |...|||||||||||||||...|.|.|.||.
rnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlk

PQFHQFTAVPHPNVKPMAYANT
..|..|.||.||.||||||||.
lkfktfeavehpdvkpmayans
subfamily_PPP7C_pd Subfamily PPP7C 172-373 3.9e-60 196.6 In-house 2-203 (383) alignment 
Range on Protein: 172-373
Range on HMM: 2-203/383.0
IEDEYSGPKLEDgKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGD
.||.|.||.|.   .| . ...|.. .| .|.|| |   .|| . |.|| .|  . . .   ....||||| ||.. ||| |.  |||||| |||.||||
vedsytgprlsl.pltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

FVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKY---TAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfsEDGVTLDDIRK
|||||. |||..| |. . |.|| ...| |||||   .|  |||  ||. ||   .... .|. .|| |||||  |. |.||.|||.   |   |. . |
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGi..sdktdlelldk

IERNR
|||..
iersk
0049330 Metallo-dependent phosphatases 185-485 7.1e-98 320.5 In-house 11-305 (309) alignment 
Range on Protein: 185-485
Range on HMM: 11-305/309.0
KVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTlketEKITVCGDTHGQFYDLLNIFELNGLPSEtNPYIFNGDFVDRGSFSVEVIL
....|....|..... .|.|. . ....| ..||.| . ..|.| .     .|.|.|| |||..|||...|..|.|.| . ..|.||.||||..|.||.|
elilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpdslevll

TLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDgVTLDDIRKIERNRQPPDSGPMCDL
.|. .||||||...|||||||. ..|..||| .|...|| |...| | .....||||  |.||.|..||||...  ..||.||..|| ...|. |..|||
lllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdl.llldqirelerpleipldgllcdl

LWSDPQ-PQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLqGSDLRPQFHQFTAVPHPN
|||||.   .|   ..||... ||..... ||. |.||.|||.|..  .||.. ..|...|||||||||...||....... ..|| ..|..| .||.. 
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavlei.dedlvisfllfepvplll

VK
..
ll
0053225 Metallo-dependent phosphatases 185-480 5.2e-91 298.0 In-house 3-292 (293) alignment 
Range on Protein: 185-480
Range on HMM: 3-292/293.0
KVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTlketEKITVCGDTHGQFYDLLNIFELNGLPSEtNPYIFNGDFVDRGSFSVEVIL
........ |..... .|.|. . ....| ..||.|.| ..|.| .     .|.|.|| ||...|||...|. |.|.| . ..|.||.||||..|.||..
slilllldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevle

TLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKY-TAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCD
 |. .||||||...|||||||. ..|..||| .|...||  |.... . .....||||  |.||.|..|||| | | ..||.||.|.|  ..|. |...|
lllalkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGl.spdlslldqireinrplriplegllld

LLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQgSDLRPQFHQFTAVP
||||||.  .|  .|.||... ||..... ||. |.||.|||.|.|  .||.. ..|..|||||||||....||......|  ..| ..|..| .|.
llwsdpdlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlald.eglvwgfklfapvl
subfamily_PPP3C_pd Subfamily PPP3C 191-486 6.8e-83 271.9 In-house 28-329 (452) alignment 
Range on Protein: 191-486
Range on HMM: 28-329/452.0
MKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETtlkeTEKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFK
.. | . .. . .|... | .|. .. ..|.| .||.|        |||.|| ||||||||..||..| |..|. |.| ||.||||.||.|..| |.  |
levlkehflkegrleeeaalkiieeaakllkkektllev....eaPitviGdihGqfydllklfevgGdPastk.ylflGdyvdrGyfsiecvlylyalk

LLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQ
. ||....|||||||.  . . . |. |.| ||. ..|. . | |. ||||  .|.. | .|||| | .  .||||.|..| ..|| |||.|||||||| 
iaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGl.speikslddikkldrfkeppasGplcdllWsdPl

PQNGRSI--------SKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHG------GRCVTVFSAPNYCDQMGNKASYIHLQGSDLrpQFHQF
 . | .         | || |. ..   .  ||..|.|  |||.||.. .||.. .          .|.||||||.|   |||. ....  ..  . .||
edygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm..nirqf

TAVPHPNVKP
...|||   |
nssphpywlp
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 191-465 1.1e-66 218.1 In-house 7-281 (299) alignment 
Range on Protein: 191-465
Range on HMM: 7-281/299.0
MKELMQWYKDQKKLHRKCAYQILVQVKEVlSKLSTLVETTLKETE-KITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGF
. .|..  . .|.| .    | |... .| .| . . ...| | |  | |||| |||. ||| ||. .|.| ..| ..| ||.||||   .|.|  |. |
lskllnvgmsekrltksvkeqelqtlcav.aksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvn.flflgdyvdrgrqnlelitlllcf

KLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYT-AQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSD
|. ||..|..||||||   .|..|||  |.. .|. .... .| . |...||.  |....| ||||| |    ||| .|.. | ..||.     ||||.|
kikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhggl.spklqtldqlrdltrpqdppnpslgidllwad

PQP-QNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQ
|.    .     ||||  ||.|| .  ..  ..| . |.|.|  .|||     . ||.|||| || |. | |. ....
pdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvd
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 196-464 8.1e-80 261.0 In-house 16-280 (298) alignment 
Range on Protein: 196-464
Range on HMM: 16-280/298.0
QWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETtlkeTEKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPD
.  |  |... .   ... ..|....| ..|||        |.|||| |||. ||| .|. .| | ..| |.| ||.||||....|||. |. .|. ||.
sekkltkvikeedveklielakkifkkqkslvev....dapikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnlevivlllaykvkypn

HFHLLRGNHETDNMNQIYGFEGEVKAKY-TAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQP-QN
.| |||||||.  .|..|||  |.| .|   ..|. | .||..|||.  | |..| ||||| |.  ..||..|...|  .....    ||||.||.  ..
nffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGl.skklksldqlrelkrpfdskeeslaidllwadpenavk

GRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHL
| . ..||||..|| || | .||. ..| ..|.| |  .|||   . . ||.||||.||.|. | |. ...
gwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkv
subfamily_PPP2C_pd Subfamily PPP2C 197-481 2e-78 256.5 In-house 10-288 (290) alignment 
Range on Protein: 197-481
Range on HMM: 10-288/290.0
WYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLketeKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDH
  |. |.|. .   ..  ..||.||| | . |        .||||| ||||.|||..| . |   .|| |.| ||.|||| .||| .  |  .|. |.. 
klkeckqleesevkelcekakeilskesnvqevkc....pvtvcgdvhgqfhdllelfkiggkspdtn.ylflgdyvdrgyysvetvtllvalkvryker

FHLLRGNHETDNMNQIYGFEGEVKAKYT-AQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGR
  .||||||. .. |.||| .|.  ||. |.....|...|..|||.  ...... .|||| |    |||.||...| .. |. ||.||||||||. ..| 
itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhggl.spsidtldkiraldrlqevphegplcdllwsdpddrggw

SISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQgSDLRPQFHQFTAVPH
.||.||   .|| |....| ..|.| .|.|.|..  |||...|  . ||.||||||| . ||.|. . |.  .|. .| || . |.
gisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaaileld.dklkysflqfdpapr
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 198-466 4.6e-62 202.6 In-house 10-277 (290) alignment 
Range on Protein: 198-466
Range on HMM: 10-277/290.0
YKDQKKLHRKCAYQILVQVKEVLSKLSTLVETtlkeTEKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHF
|   . .  |  ..|| ...|.|  | .|.|      . |.. || |||. .||. |.  | | . . ..| ||.||||. |.|| | || .|..|. . 
ygvldafsdkdileilekieeileplpallev....eapivivgdihgqldallryfdavgyppkvk.flflgdyvdrgakslevslllfcykiryskkv

HLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQP--PDSGPMCDLLWSDPQPQN--
||||||||. ..|..|||  |.  | .....  . .||. |.|   .. |.| ||||. |..  . . .. ... | |   | | . ||||.||. .   
hllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggi.sqkiesweslkalkkprvpltcdeglqvdllwadptrdkdd

GRSIS-KRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQG
  ..  .|..|  || ..   .|..  |. |.|.|||| ||..     ..||||||| |. .  |  . ...  
tialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvse
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 201-465 4.6e-68 222.7 In-house 5-270 (284) alignment 
Range on Protein: 201-465
Range on HMM: 5-270/284.0
QKKLHRKCAYQILVQVKEVLSKLStlVETTLKetEKITVCGDTHGQFYDLLNIFELNGLP-----SETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPD
|| |..|  ... .. .|.. | .  ..  ..    ....|| |||| ||| ...||| |     .. . |.| ||.|||| ||.|||. || .|||.||
qkllkekelielcyrarelfwkek..lkleie..apvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpd

HFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQ-NG
.  |||||||.  .|. |||  | | .|. ..|| |   |. .||.  .. |.. ||||. ||| . |... |.||  . || | ..|| |.||. . .|
kvfllrgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggi.sedlldlkqldklerpidipdigviadltwadpeaeveg

RSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQ
   |.||    ||..  | ||.. .|| ..|.|.|  .|||     . ||.|||| || |. | |. ....
ykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvd
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 201-465 9.4e-45 146.1 In-house 4-288 (302) alignment 
Range on Protein: 201-465
Range on HMM: 4-288/302.0
QKKLHRKCAYQILVQVKEVLSKLSTLVETtlkeTEKITVCGDTHGQFYDLLNIFELNGLPS----------ETNPYIFNGDFVDRGSFSVEVILTLFGFK
.|.....  .... .| | |.| .||.|     .  .|. || |||| ||. |.  .               .. ..| ||.||||| |.| |  .| .|
kkeysksellllieaviellkkektlaei....spPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalk

LLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKY----TAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGP-MCDLL
.||| .. ||||||||  .|  |||..|.. ..    . ...| | ||| ..|||  .  |.| .|||. |.   .|.||.||.|  .   . .   |||
vlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkikrplkevtedslaqdll

WSDPQPQNGRSI----------SKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQ
..||   ..  .           .||.|  |     . . .  ||. |.|.| .  ||.      . .|.||||.| ... || . ....
fadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
subfamily_PPP1C_pd Subfamily PPP1C 202-465 2e-84 276.1 In-house 8-266 (282) alignment 
Range on Protein: 202-465
Range on HMM: 8-266/282.0
KKLHRKCAYQILVQVKEVLSKLSTLVETTlketEKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLR
 ||...   ..| . .|.| . ..|.| .    . ....|| |||..|||..|| .| |.|.| |.| ||.||||..|.|.|. |. .|. ||....|||
vklkeaeieallkkareillsqpillele....aPvkivgdihGqyadllrlfetsgaPpesn.ylflGdyvdrGkqsletivlllaykikypenlfllr

GNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQ-NGRSISKR
||||. ..|.||||  |.| .|...... | .||..||||  .. |.| .|||| |..   |..||||.|  . |..| .||||||||. . .| | ..|
GnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGl.spelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQ
||| .||.|| ..||..|.|| |.|.|.|  .|||     . ||||||||||....|... ....
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvd
subfamily_PPP6C_pd Subfamily PPP6C 202-481 7.2e-75 244.8 In-house 13-286 (290) alignment 
Range on Protein: 202-481
Range on HMM: 13-286/290.0
KKLHRKCAYQILVQVKEVLSKLSTLVettlKETEKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLR
| |  . . ..  .|...|.. |...      .  .||||| |||||||...|   |   .|. |.| ||||||| .|.| .  |. .|. |||.  |||
kylpendlkklcdlvldllleesnvq....pvsspvtvcgdihgqfydleelfrtggqvpdts.yvflgdfvdrgyysletftrlltlkakypdritllr

GNHETDNMNQIYGFEGEVKAKYT-AQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKR
||||. .. |.|||  | . ||  |. .  ...||. |..|  |...|| .|||| | |  |||.|| |||... |  |..|||.||||.  .  ..|.|
gnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGgl.spdvktldqirvieraqeiphkgafcdlvwsdpedvetwavspr

GVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDlRPQFHQFTAVPH
|    ||  ||| |.. |||. |.|.|..  ||..     . |||.|||||| . || || ..|. ..   ... |.|||.
gagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae.ereaklfkavpd
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 202-465 8e-45 146.3 In-house 4-287 (302) alignment 
Range on Protein: 202-465
Range on HMM: 4-287/302.0
KKLHRKCAYQILVQVKEVLSKLSTLVETtlkeTEKITVCGDTHGQFYDLLNIFELNGLPS----------ETNPYIFNGDFVDRGSFSVEVILTLFGFKL
|.....  .... .| | |.| .||.|     .  .|. || |||| ||. |.  .               .. ..| ||.||||| |.| |  .| .|.
keysksellllieaviellkkektlaei....spPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkv

LYPDHFHLLRGNHETDNMNQIYGFEGEVKAKY----TAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGP-MCDLLW
||| .. ||||||||  .|  |||..|.. ..    . ...| | ||| ..|||  .  |.| .|||. |.   .|.||.||.|  .     .   |||.
lyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkikrplkevtedslaqdllf

SDPQPQNGRSI----------SKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQ
.||   ..  .           .||.|  |     . . .  ||. |.|.| .  ||.      . .|.||||.| ... || . ....
adpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
PP2Ac_SM00156 205-477 3.9e-109 356.9 In-house 2-268 (271) alignment 
Range on Protein: 205-477
Range on HMM: 2-268/271.0
HRKCAYQILVQVKEVLSKLSTLVETTlketEKITVCGDTHGQFYDLLNIFELNGlPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH
........| .|||.|.. ..|||..    ...||.||.|||..|||...||.| ......|.|.||.||||..|.||||.|| .|.|||....||||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSeDGVTLDDIRKIERNRQPPDSGPMCDLLWSDP-QPQNGRSISKRGVS
|....|.||||| |||.||....|| |.|.|..|||| ... |.|.||||| . .  .||||||..|....|..|...||||||| |...| ..||||.|
EsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp.eleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrgls

CQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLqGSDLRPQFHQFT
..||.|..| ||..|||..|||.|||. ||||. . ...||.||||||||...|||.....  ..|.....|..
vvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkv.eknlklsieqlk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 205-465 5.7e-70 228.5 In-house 11-269 (287) alignment 
Range on Protein: 205-465
Range on HMM: 11-269/287.0
HRKCAYQILVQVKEVLSKLSTLVETtlkeTEKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH
  |  ...| ...|.|  |..|.|     .. ||..||.|||. |||.||.  | ..... |.| ||.||||. |.||.| || .|..|| . |||||||
sdkdilevlekieeileplpallev....eapitivGdihGqlddllrifnavGaapkvq.ylflGdyvdrGakslevslllfslkiaypkkvhllrGnh

ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDS--GPMCDLLWSDPQPQ-NGRSIS-KR
|  ..|..|||. |.| |.  ..|. | .||. |||   .. ..| ||||. |..  .||... ... ..| .   | . ||||.||. . ..  .   |
evkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGi.spklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkir

GVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQ
..|  ||  .   .|.. ..| |.|.|||. |||.     |.||||||| |. .  | .. ....
aisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvs
PPP_3 206-475 3.8e-103 337.2 In-house 4-268 (271) alignment 
Range on Protein: 206-475
Range on HMM: 4-268/271.0
RKCAYQILVQVKEVLSKLSTLVETTlketEKITVCGDTHGQFYDLlNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHE
 . ..... ..||.|.| |.|||..    ...|||||.|||..|| .... ||.||... |.|.||.||||..|.||.|.|. .|..||...||||||||
enelkelvkklkeilekesnlveis....apvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhE

TDNMNQIYGFEGEVK-AKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGvTLDDIRKIERNRQPPDSGPMCDL-LWSDPQPQNGRSISKRGVS
....|..|||. ||.  |.....|. ..||||.||||..|..|||..||||...   .||.|.|.||... |..|...|| |.|||. ..| . ||||..
srqinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsik.sldqikklerkievpeegklldlllssdpekeeglenskrGag

CQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGsDLRPQFHQ
. ||||||. |||.|.|..|||.||.| ||||. | |..||||||||||....|......|.  .|...|.|
llFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailklee.altsefkq
subfamily_PPP4C_pd Subfamily PPP4C 208-480 5.9e-79 258.3 In-house 13-286 (288) alignment 
Range on Protein: 208-480
Range on HMM: 13-286/288.0
CAYQILVQVKEVLSKLSTLV--ETTLKET-EKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH
|      .||.. .| . ..  |. ...    .||||| ||||||||..|...|   ||| |.| ||||||| .||| .| |  .|. |||. .|.||||
celikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetn.ylflgdfvdrgfysvetfllllalkvrypdritlirgnh

ETDNMNQIYGFEGEVKAKYT-AQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVS
|. .. |.|||  |.  ||  |..... .|||..|.||  |.||....|||| | .  |||.|| |.|... |..||.||||||||. ..| ..| ||  
esrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhggl.spsistldeirsidrkqevphegplcdllwsdpedaegwavsprgag

CQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLqGSDLRPQFHQFTAVP
  || ||.. | |.|... |.|.|..  ||| .    . .||.|||||| . ||.|. ..|  ..|. .|. | |..
ylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaailel.deeldkdfkifeaaa
subfamily_PPZ_pd Subfamily PPZ 209-460 3e-56 184.1 In-house 30-276 (300) alignment 
Range on Protein: 209-460
Range on HMM: 30-276/300.0
AYQILVQVKEVLSKLSTLVETtlkeTEKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDN
  || .. .|..    .|.|     .  . . || |||. ||| .|   |.|  .| |.| ||.||||  |.| || |. .|. ||. | |||||||  |
ilqicikarelflaqpallel....spsvkivgdvhgqyadllrlftkcgfppsan.ylflgdyvdrgkqsletillllcykikypenffllrgnhecan

MNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQP-QNGRSISKRGVSCQFG
. ..|||  |.| .   .... | . |. ||||  . ||.. .|||| |    ..|.||.. |  . || | . |||||||   .|     .||||  . 
vtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhggl.spvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

PDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKAS
    . ||..  .| . |.| |  .|||.      |||||||||| .. |  .
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwga
PPP_1 211-464 1.5e-101 332.1 In-house 4-264 (264) alignment 
Range on Protein: 211-464
Range on HMM: 4-264/264.0
QILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLlNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMN
. |...|. |..| .  |..|. .|.||||||.||||.|| ...  .|.||... |.|.||.||||..|||..|.|. .|| ||....|||||||.....
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

QIYGFEGEVK-AKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEdGVTLDDIRKIERNRQPPDSGPMCDLL--------WSDPQPQNGRSISKRG
..|||. ||.  ||....|.....||..||||..|..|.||.|||| .|   .||.|||..|... |..|..||||        ..|.. ... . |.||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspe.ldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHL
....||.|||. ||..|||..|||.|||| ||||... ...||.|||.||.....|...|..|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
subfamily_PPG1_pd Subfamily PPG1 211-480 9e-68 221.7 In-house 21-297 (300) alignment 
Range on Protein: 211-480
Range on HMM: 21-297/300.0
QILVQVKEVLSKLSTLVETtlkeTEKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMN
..  ..||.| | | ..|        .|| || ||||||.|.||.. |   .|| |.| ||.|||| .||| |  |  .|| ||   .|||||||. .. 
eltdklkellvkesnviei....rspvtvvgdvhgqfydvleifkiggqvpdtn.ylflgdyvdrglysvetisllivlklrypsritllrgnhesrqit

QIYGFEGEVKAKY--TAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQ---------PQNGR---S
|.||| .|.  ||   ..... ..|.|..| ||  |. ..  .|||| | .  ..|.|. ..| |. |. | ..|||||||.         |..      
qvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhggl.spsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfv

ISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDlRPQFHQFTAVP
.|.||    .| ||.. ||. |... |||.|..  |||..   ..  ||.|||||| . ||||| . |.  | .  |  . . |
vsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekd.eryfnvyeeap
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 212-463 5.1e-72 235.3 In-house 14-260 (280) alignment 
Range on Protein: 212-463
Range on HMM: 14-260/280.0
ILVQVKEVLSKLSTLVETtlkeTEKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQ
.. ..|..|.  .|.||        ..|||| |||. ||| .|.  ..| ..| |.| ||.||||.. .|||| |. .|. ||..| .||||||. ..|.
viekckkiltaqatmvev....dapvavcgdlhgqytdllrlfarvsfppdqn.ylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinr

IYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQ-PQNGRSISKRGVSCQFGPDV
 |||  ||| .|. ..|. | |... |||.  ..|..| ||||| |.. |.|||.... |  ...|.    ||||.||.  . | . . |||| .|| .|
kygfkdevkrryslalynefqelldslplvalvsgrilcmhggl.sqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganv

TKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIH
 | . |  ..| |.| |.|  .|||   . . |||||||.|.... |.|. . 
vkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavli
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 213-479 3.1e-65 213.2 In-house 17-277 (281) alignment 
Range on Protein: 213-479
Range on HMM: 17-277/281.0
LVQVKEVLSKLSTLVETtlkeTEKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQI
. .|. ..|. ..|||      . |.| || |.|| || ..||| | ..|.  ..| ||.||||  |.||.. || .|. |.|.  |||||||. ..|.|
ireveaifseekaLvei....dkPivvvGdlhaqfndlkrlfellgrvpeev.lvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnki

YGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQN-GRSISKRGVSCQFGPDVT
|||  | . ||  ... || . |. ||... |. .||.||||| | . ..||..|.. .  ...| | . ||||.||...  .   | ||.|  || .| 
ygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGl.sPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvv

KAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQgSDLRPQFHQFTAV
.    . ....|||.| |  .||||  | . .||||.||||..  | |. . ..  .|  .. ..   
ddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvd.etlgislvalvpa
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 215-463 1.2e-58 191.8 In-house 14-259 (284) alignment 
Range on Protein: 215-463
Range on HMM: 14-259/284.0
QVKEVLSKLSTLVETtlkeTEKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYG
.. ... |   |.|.       | .||| |||| ||| .|. ||.|  .| |.| ||.||||   .| || || .|...|.|| .||||||   .|.|||
hafsifnkqpmliev....nspinicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiyg

FEGEVKAKYT-AQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPM-CDLLWSDPQ-PQNGRSISKRGVSCQFGPDVT
|  |.. .|    .|  |  ||  .||.  .  ..| ||||. |.    . ..| |.|  . |.   .  |.|||||   |.|     ||||  || |  
fyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggv.skmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdal

KAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIH
. .|.  ..| ..|.|.|  .|||.    | ||.|||| || |. | |. ..
rklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmy
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 228-483 4.2e-59 193.3 In-house 25-279 (280) alignment 
Range on Protein: 228-483
Range on HMM: 25-279/280.0
ETTLKETE-KITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQ
|. | |.|  | | || | |. |.  .|.| |   | .  .| ||.||||   .||.. || .|. | |. .|||||||| ..|.||||  |.. ||   
esnlceaeapikvigdihaqyqdmnrlfdligrvpeek.lmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygvg

MYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQ-NGRSISKRGVSCQFGPDVTKAFLEENNLDYIIR
..  |  .|. .|..  |. .||.||||| | . . || ||.| |  .| | | . |||||||  . .|   | ||.|  ||  | .   .  ..| |||
lwwdfqscfnrmpmsgliskrvlcmhggl.spelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliir

SHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQgSDLRPQFHQFTAVPHPN
.|.|  .|||.  | | .|||| |||| |. | |. . |. ..|.  |.|.   | |.
ahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvcln.anlqvsfqqlippplpe
subfamily_PPPLV_pd Subfamily PPPLV 229-468 1.8e-46 151.7 In-house 17-279 (290) alignment 
Range on Protein: 229-468
Range on HMM: 17-279/290.0
TTLKETEK-ITVCGDTHGQFYDLLNI---FELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYT
  | | .  . | || ||.. ||  .   .   |       ..| ||.|||| ||||.|  |.  |.||| ...||||||| . . . . . || . |. 
erllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfg

AQM---YELFSEVFEWLPLAQCINGKVLIMHGGLF--SEDGVTLDDIRKI-ERNRQPPDSGPM-CDLLWSDPQPQNGRSI-------------SKRGVSC
 ..   .| | .||..||||  |. ||. .|.|.   .  .  .  |..| || ... |  |.  |.|||||. ..  |.             ..|| ..
dsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtgh

QFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQmGNKASYIHLQGSD
 |. |  .|||..|||....|.|||| .|... ..|| .||||. .|| .  |.|. | .. . 
vfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkkk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 232-261 1.6e-07 23.8 In-house 33-62 (317) alignment 
Range on Protein: 232-261
Range on HMM: 33-62/317.0
KETEKITVCGDTHGQFYDLLNIFELNGLPS
.    .|..|| |||| ||| ...||| | 
eleapvtivGdihGqfedllalldlnGwpl
subfamily_YNL217W_pd Subfamily YNL217W 233-342 3e-07 23.2 In-house 8-105 (235) alignment 
Range on Protein: 233-342
Range on HMM: 8-105/235.0
ETEKITVCGDTHGQFYDLLNIFE-LNGLPSETNPYIFNGDFVDRGSFSVEVILTLfgfkllYPDHFHLLRGNHETDNMNQIygfegeVKAKYTAQMYEL-
   .. | || || . .|.....  .|   |    .. ||....|  ||||.  .        |. . ..||||   . ..         |    . .| 
lgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay......kwvkkpkgaeple

FSEVFEWLPlaQ
||. |..|.  .
fsskfsfle..s
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 234-463 5.5e-63 206.0 In-house 49-280 (297) alignment 
Range on Protein: 234-463
Range on HMM: 49-280/297.0
TEKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYT-AQMYELFS
   | |||| |||| ||| .|   | |  .| |.| ||.|||| ||.| |. |. .|. .|  . ||||||| . .|..|||  |.. .|   .||  | 
napikvcgdihgqfpdllrlfhrggwpptan.ylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafq

EVFEWLPLAQCINGKVLIMHGGLFS--EDGVTLDDIRKIERNRQPpDSGPMCDLLWSDPQP-QNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEV
.||.||||.  |  |.| |||||     . .||| .|||||...    . ..||||.||     |    .||  | || |       | .|| . |.|.|
dvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqv

KAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIH
  .|||.  | . ||.|||| || |. | |... 
vqdgyeffagrklvtifsaphycgqfdncaafms
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 235-462 2.8e-48 157.8 In-house 7-240 (263) alignment 
Range on Protein: 235-462
Range on HMM: 7-240/263.0
EKITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTA-----QMYE
  | .|||||||. ||| ||.  |  ..|. |.| ||.|||| .|.|||. || .||  | ..||||||||   .|. |||  |.| ..        .|.
apinicgdthgqyndllrifnacgaatktq.ylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvyn

LFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPM-CDLLWSDPQPQ-NGRSIS-KRGVSCQFGPDVTKAFLEENNLDYIIRS
 | .|| ..||.  .. ..| ||||. |    .||||| |    .   . |. |||||.||. . .|      | .|  ||      . .  ..| |.|.
hfnqvfsymplcaivskrilcmhggi.sphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivra

HEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYI
|.|   || .    | .|||||  |  .. | |. .
hqvveygyaffadrrlitvfsasryqielcnyaavv
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 236-460 1.2e-47 155.6 In-house 48-274 (307) alignment 
Range on Protein: 236-460
Range on HMM: 48-274/307.0
KITVCGDTHGQFYDLLNIFELNGLPSETNpYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVK---AKYTAQMYELFS
   | || |||| ||.|.| | | | ||  |.| ||.|||| .|.|.|| || .|. ||..  |||||||   .|. |||  |.     |   ... || 
pcvvvgdlhgqfndlinmfillgrppetv.yvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalfq

EVFEWLPLAQCINGKVLIMHGGLfSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQN-GRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKA
 .|. ||..  |  |.| ||||| |     ||..|.  .  . |  | . |.||.||.|       | ||    || .|         .. |||.|..  
rcfnnlpisaliatkilcmhggl.spaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcf

EGYEVAHGGRCVTVFSAPNYCDQMGNKAS
.|| |  | . .|.|||| ||.   |   
dgywvlsgrklitifsapmycnfyknagc
Metallophos Calcineurin-like phosphoesterase 236-430 1e-44 146.2 Pfam-A 2-199 (200) alignment 
Range on Protein: 236-430
Range on HMM: 2-199/200.0
KITVCGDTHGQFYDL---LNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTL--FGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVK----------
.|.|.||.||...||   |.|.. .. ... ....|.||.||||  | |..  |  .  |||.|....||||||| |..|. |||  |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------AKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDirkiernrqppdsgpmcdllwsdpqpqngrs
                         ...   .| . |.|..|||.  ..||.|..||.|.|..| ..|                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

iskrgVSCQFGPDVTKAFLEENNLDYIIRSHEVK
      |. ||||..  .||....|...|.|. |
.....gselfgpdalekllekygvdlvlrGHtHk
PPP_4 237-430 8.8e-78 253.9 In-house 1-197 (197) alignment 
Range on Protein: 237-430
Range on HMM: 1-197/197.0
ITVCGDTHGQFYDL-LNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVF
.||.||.|||..|| |..... |||||.. |.|.||.||||..|.||.|.|. .|| ||....|||||||. ..|..|||. ||. |....... . .||
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

EWLPLAQCINGKVLIMHGGLFSEDGvTLDDIRKIERNRQPP-DSGPMCDL-LWSDPQ-PQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVK
..||||..|..|||..||||..|   .||.|..|||... | ... ..|| |||||.  |.| . |.||... ||||||. |||.|||..||||||.|
dllplaalidekvlvvhgglsdele.sldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshelk
PPP_2 237-430 4.3e-76 248.0 In-house 1-198 (198) alignment 
Range on Protein: 237-430
Range on HMM: 1-198/198.0
ITVCGDTHGQFYDLlNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVK-AKYTAQMYELFSEVF
.|||||.|||..|| .|.  |||||... |.|.||.||||..|.||.|.|. .|| ||...||||||||....|..|||. ||.  |.....|. ..|||
vtvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevf

EWLPLAQCINGKVLIMHGGLFSEDGvTLDDIRKIERNRQPPDSGPMCDL-----LWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVK
|.||||..|..|||..||||..|   .||.|.|.||... |..|...||     |..... ... . |.||... ||||||. .||.|.|..|||.||||
elLplaalidekvlvvHGGlseeik.lldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHevk
PPP_5_Dcr2 237-430 1.4e-75 246.6 In-house 1-199 (199) alignment 
Range on Protein: 237-430
Range on HMM: 1-199/199.0
ITVCGDTHGQFYDLLNIFELNG-LPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAK-YTAQMYELFSEV
.|||||.|||..||| |.. .| .|||.. |.|.||.||||..|.||.|.|. .||.||...||||||||. ..|.||||. ||. | . ...|. .|.|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FEWLPLAQCINGKVLIMHGGLFSEDGvTLDDIRKIERNRQPP-DSGPMCDL-LWSDPQ-PQNG-RSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVK
|.|||||..|..|||..||||..|   ......||||... | ..| ..|| |||||.  |.|    |.||... ||||||. |||.|||..||||||.|
fdwlPlaalidekvlvvhgglspeik.siellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 264-465 7.6e-64 208.9 In-house 101-302 (317) alignment 
Range on Protein: 264-465
Range on HMM: 101-302/317.0
NPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTL
. |.| ||.|||| ||.||.. || .||||||. .|||||||. ..|. |||  ||| .| |..|| |  .|. |||.  .| |.| ||||. ||. . |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGi.seelldl

DDIRKIERNRQPPDSGPMCDLLWSDPQPQ-NGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYI
. . |..|  . || | ..|| |.||... .|   |.|| .  ||..  |.||.. .|| ..|.|.|  .|||   . . ||.||||.|| |. | |. .
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

HLQ
...
svd
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 265-462 1.8e-55 181.4 In-house 121-318 (339) alignment 
Range on Protein: 265-462
Range on HMM: 121-318/339.0
PYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLfSEDGVTLD
 |.| ||.|||| ||.||.. |  .|| |||. .|||||||.  .|  |||  ||. .| ||.|| | ..|. .|..  ||  .. ||||. ||   ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggi.sehltsfn

DIRKIERNRQPPDSGPMCDLLWSDPQPQ-NGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYI
..  ..|  . || | . || |.||.|  .|   | || |  |||   .|||.. .|. .|| |.|  .|||.  | | ||.||||||| |  | |. .
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavf
subfamily_PPP7C_pd Subfamily PPP7C 381-479 1.6e-31 102.4 In-house 237-335 (383) alignment 
Range on Protein: 381-479
Range on HMM: 237-335/383.0
MCDLLWSDPQPQNGRS-ISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLqGSDLRPQFHQFTAV
. |.|||||. ..|    . ||  . ||||||| .|.  ||...||||| | ||||..|  ...|.||| || ..  |. .|..| |.||.|.. |. | 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvkl.gkdltprivqyqas