Gene PPP6C in Homo sapiens

Synonym: PP6, PP6C, RP11-366O20.1, PPP6C

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP6C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP143_AA protein Get Run
HsapP143_AA_61-330 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP6C_pd Subfamily PPP6C 62-330 3.4e-175 574.0 In-house 21-289 (290) alignment 
Range on Protein: 62-330
Range on HMM: 21-289/290.0
ERLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYG
..|||.|.|||||||||||||.|||||||||||||||.||||||||||||.|.|.|||||||||||||||.||.||||.|||||||||||||||||||||
kklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvyg

FYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEF
|||||..||||||||.|||||||.||.||.||||.||||||||||.|||||||.|||.||||||||||||||||||||.|||.||||||.|||.|||.||
fydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvetwavsprgagylfgskvtkef

VHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSER
||||||||||||||||.||.|.|||||||||||||||||||||.|||. ..| ..||.|||.||||.||
vhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdeer
PPP_1 62-309 1.3e-111 365.1 In-house 7-262 (264) alignment 
Range on Protein: 62-309
Range on HMM: 7-262/264.0
ERLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYG
 .|.. . .|| .|.|.. ||...||||||||||.||..||..||..|.|||.|.||.||||..|.|....||||| |.|....||||||||||.|.|||
aelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvyg

FYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDL--------VWSDPEDVDTWAISPRGAGWLF
|..|...|..... ....|.|||.|..||||||.||.|||||||....|||||...|..|.|..|..|||        ...|.|. ...| |.||||.||
FkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagylf

GAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIM
|..||..|.. ||||||.|||....|||.|....|.||..||.||.....| ....
gkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv
0045823 Metallo-dependent phosphatases 62-330 4.5e-110 361.4 In-house 49-329 (473) alignment 
Range on Protein: 62-330
Range on HMM: 49-329/473.0
ERLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYG
 .|.|.....| .|.|....| ...|.||||||..||..|..  |  |.....|.||.||||..|||.. .||||| |.|....|||||||.|.....||
lklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglyg

FYDECQTKYgNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDT--------WAISPRGAGWLF
|.||.  || ... .... .... | .||.|...||.||||||||...|||||.||| .|||. |...||.||||...|         .  ||||||.||
fgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylF

GAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEK------LVTVWSAPNYCYRCGNIASIMVFKDvNTREPKLFRAVPDSER
|.....|| . |.|.||.|.|. | |||...|| |      ..||.||||||.|.|| |...|. . .......|...|.  .
gpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvide.dlisfiqfdpsphpli
0053225 Metallo-dependent phosphatases 62-326 2.7e-101 331.8 In-house 28-292 (293) alignment 
Range on Protein: 62-326
Range on HMM: 28-292/293.0
ERLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYG
 .|.......|..|.|....| ...|.|||||...|| .|..  | .|.....|.||.||||..|||....|||||...||...|||||||.......||
llllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElmllnglyg

FYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEF
|.||.  |||.|. |........ | .||||...||.||||||||. .||||| |.| ..||. |...||.|||| ....|..|.||.|..||. .. .|
fgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsgwlpsyrglgvvfghtavlrf

VHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVP
...|.|.||.|.||.|..||...||.|||||.|||||..|.|| ........  ....|||..|.
lkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP4C_pd Subfamily PPP4C 63-326 1.1e-142 467.4 In-house 23-286 (288) alignment 
Range on Protein: 63-326
Range on HMM: 23-286/288.0
RLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGF
.||  . ..|.|||||| | .||||||||||||||| |||. ||.||.|||.|.|||||||.||.|||  |||||...||||||.|||||||||||||||
alcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygf

YDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFV
||||  |||.|| |||||.|||.|..||.||..|.||||||||.|.|||.||.|.|.||.||.|..|||.||||||...||.||||||.|||..|...|.
ydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaegwavsprgagylfgsdvveqfn

HINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVP
. |...||||||||| ||||..|.||..||||||||||||||.|.|. ...   .. |.| |..
eandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPP2C_pd Subfamily PPP2C 63-323 2.3e-132 433.5 In-house 24-284 (290) alignment 
Range on Protein: 63-323
Range on HMM: 24-284/290.0
RLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGF
.||. . ..| .|||||.|..|||||||.||||.|| |||. ||..|||||.|.||.|||||||.|| |.| ||| ....|||.||||||||||||||||
elcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqvygf

YDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFV
||||  |||||| |.| |..||.|...||.||||.|.|||||| |.|||.||...| ||.||.|..|||.||||.| . |.|||||||. || .....| 
ydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrggwgisprgagytfgkdisekfn

HINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFR
. |.|.|| |||||| |||....|...||..||||||||||| |.|. ..|  ...   | 
ktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfd
subfamily_PPG1_pd Subfamily PPG1 63-328 1.6e-116 381.8 In-house 21-299 (300) alignment 
Range on Protein: 63-328
Range on HMM: 21-299/300.0
RLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGF
 |.| . .||..||||. . .|||| ||.||||||. |.|. |||||||||.|.||.||||.||.|| . |..|| ..| ||||||||||||||||||||
eltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygf

YDECQTKY-GNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPE----------DVDT--WAISPRGA
| ||  || ||.. |.| |..|| |..||.|||.| ||||||||.....|||. ..| .|.|..||..||.|||||          | .   . .|.|||
yteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrga

GWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDS
|. .| .|...|.. |... | |||||..|||. .||.|| |||||||||||||| |||.  .. . |  . . . |.|
gysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapes
PPP_3 63-322 4.9e-116 379.5 In-house 9-269 (271) alignment 
Range on Protein: 63-322
Range on HMM: 9-269/271.0
RLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGF
.|.. . ..| .|||.. .|.|||||||||||..||.|||..||..|.|.|.|.||.||||..|||....||||| |.|....|||||||||||..||||
elvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkvYgF

YDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDL-VWSDPEDVDTWAISPRGAGWLFGAKVTNEF
..|...|.|... ......||..|..||||||..|.|||||||.||.||||...||..|.|..|...|| ..||||. .... |.||||.|||..||.||
kkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgpdvteef

VHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLF
.. |.||||.|||.|..|||....|.|.|||.||||||.|..| ..|. ... .|.|.|..
leknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
0049330 Metallo-dependent phosphatases 63-330 5e-105 343.9 In-house 37-304 (309) alignment 
Range on Protein: 63-330
Range on HMM: 37-304/309.0
RLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGF
.|.......|..|.|....| ...|.||||||..|| .|..  | .|.....|.||.||||..|||....||||| ..||...|||||||.|.....|||
llllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrllnglygf

YDECQTKYGnANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPE-DVDTWAISPRGAGWLFGAKVTNEF
.||.. ||| |. |........ | .||.|...|||||||||||...||||| .|| .|||. | .|||.||||  .....| .|||.|..||. ....|
gdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprglgvvfghtaverf

VHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSER
...|.|.||.|.|..|..||...||.||.||.||||||.|.|| ........  .....||..||   .
lkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll
PP2Ac_SM00156 63-320 2.1e-104 341.3 In-house 8-265 (271) alignment 
Range on Protein: 63-320
Range on HMM: 8-265/271.0
RLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGF
.|.. |...| .|.|.  ||.||||.||||||..|| .|....|..|...|.|.||.||||..|.|. ..|.||| ..|....||||||||......|||
elleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnkiygf

YDECQTKYgNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDP-EDVDTWAISPRGAGWLFGAKVTNEF
..|.. || .....  ....|..|..|||.|..|||.||||||....||.|| ..|..|.|..| ..||.|||| ........| ||.. .||.....||
eeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgedavkef

VHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPK
.. ||||||.|||..|.|||.|..|.||||..||||||....| |... ...  . . .
lkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsie
subfamily_PPP1C_pd Subfamily PPP1C 63-313 5e-98 320.8 In-house 17-267 (282) alignment 
Range on Protein: 63-313
Range on HMM: 17-267/282.0
RLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGF
.|...  ..||... .  .. ||...||||||..||  || |.|  |..||.|.||.||||  |||| . |||.| |.|... |||||||| .|...|||
allkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinriyGf

YDECQTKYGNAnAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPE-DVDTWAISPRGAGWLFGAKVTNEF
||||...|..   |.  |.||..| .|||.||.||||||||||..| |.|||.|.|  |.|.||  |||.||||. .| .|. . ||  . ||..| ..|
ydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfgkdvvekf

VHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKD
.. |.|.||.||||.|..||.|. ...||||.|||||| . .| ....  ..
lqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvde
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 63-312 5.5e-86 281.3 In-house 31-281 (298) alignment 
Range on Protein: 63-312
Range on HMM: 31-281/298.0
RLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGF
.|.. . ... . . .  | .|..||||||||. ||  ||  .|  ||.||.|.||.|||| ..||. . ||| |.|.|... |||||||  .| .||||
klielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceainrvyGf

YDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPED-VDTWAISPRGAGWLFGAKVTNEF
|.||. .| . . .    .||..| ..||| ..|||.|||||. .|.|||.|...| .. ...    ||.|.|||. |  || . ||..  ||..| ...
yeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGvsvvfGedvvkdl

VHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFK
..  .. |..||||.| .||.|. . ||||..|||.|| .  | |..|  .
lekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvd
subfamily_PPP3C_pd Subfamily PPP3C 63-313 1.7e-82 270.6 In-house 48-311 (452) alignment 
Range on Protein: 63-313
Range on HMM: 48-311/452.0
RLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGF
.. . ...|| .|...  |..|.||.|||||||||| .||  ||.  .|.|.|.||.|||||.|.|.  ||.||| ..|... |||||||.| .|. . |
kiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftf

YDECQTKYGNaNAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPE-DVDTWA-------ISPRGAGWLFG
 .||..||.. . .  |.. ||.| .|||...| |||||||||.||.||.|....| .|.|..|..|||.||||  | .  .        |.||  ....
keeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfys

AKVTNEFVHINNLKLICRAHQLVHEGYKFMFD------EKLVTVWSAPNYCYRCGNIASIMVFKD
 | . ||.. |.|  | |||.  ..||.   .        |.|..|||||.    | |... ...
ykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 63-313 4.4e-76 249.0 In-house 31-282 (299) alignment 
Range on Protein: 63-313
Range on HMM: 31-282/299.0
RLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGF
.||.   . ..... .  | .|. ||||||||. ||  .|   |  ||.|..|.||.||||   ||. | ||. | |.|.|. .||||||   | .||||
tlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygf

YDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPED-VDTWAISPRGAGWLFGAKVTNEF
|.||. .|  .  |    . |... .. ||  .|||.|||||| ..||||.| . | |. |      ||.|.||.. |  |    ||  ..|| .| .. 
yeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvfgqdvvadv

VHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKD
..  .. |..||||.| .||.|. . ||||..||| || .  | |.||   .
isrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvde
subfamily_PPPLV_pd Subfamily PPPLV 63-312 2.7e-52 170.9 In-house 4-277 (290) alignment 
Range on Protein: 63-312
Range on HMM: 4-277/290.0
RLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLC----ELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQ
 |||   | |..| .. .. .|. | ||.||.. ||      |.||| ..  ....|.||.|||| .|.|  .||||||  .| .. ||||||| . ...
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

VYGFYDECQTKYGNA--NAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQ---EIPHKGA--FCDLVWSDPEDVDTW---------
 . .. |.. |.|.   ..|   ..|||.| .|| ||....|||.|.   |.|  .| .|.      . . .||    |..||||..             
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

----AISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFK
      . || | .|...  . |.. |||. . |||.  ..|...  . .|.||.|. .||    . | |.| |
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvdk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 63-104 3.7e-07 22.6 In-house 16-57 (317) alignment 
Range on Protein: 63-104
Range on HMM: 16-57/317.0
RLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRT
 ||    .|. .|     . .|||..||||||| ||  |.  
elcyrarelfwkeplkleleapvtivGdihGqfedllalldl
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 64-312 1.3e-76 250.8 In-house 16-270 (284) alignment 
Range on Protein: 64-312
Range on HMM: 16-270/284.0
LCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQV------PDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQIT
||    .|. .|.  . . .||...||||||| ||  |.   |         ...|.|.||.|||| .|.|  | |.|.| ..||...||||||||| . 
lcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvn

QVYGFYDECQTKYGNAnAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPE-DVDTWAISPRGAGWLFGAK
. |||| ||. .| .|  .      |  . ..|.....|.|.|||.| |.  |.|.  .||  .||  |  .||.|.||| .|.... |||||| .||||
mqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprgagkvfgak

VTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFK
  .||..  .|.|. ||||.| .||.|. | ||||..||| || .  |||...  .
avkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvd
subfamily_PPZ_pd Subfamily PPZ 64-311 2e-69 227.4 In-house 33-280 (300) alignment 
Range on Protein: 64-311
Range on HMM: 33-280/300.0
LCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFY
.|    .|.| . ..  .| .| . ||.|||. ||  ||   |  | .||.|.||.||||  ||||   ||. | |.|. . |||||||  ..|.|||||
icikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfy

DECQTKyGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDV-DTWAISPRGAGWLFGAKVTNEFV
|||. .  | . |.     |. | .||..  .|.|||||||| ....|.|| . |  ..|  |   ||.|||| |  . |    ||  . .     |.|.
deckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynkvainkfl

HINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVF
    . |.|||| .| .||.|. |  ||||.||||||    |  ..|  
nkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsv
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 64-311 4.7e-69 225.9 In-house 31-281 (297) alignment 
Range on Protein: 64-311
Range on HMM: 31-281/297.0
LCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFY
| |   |..  . ..  | .|. ||||||||| ||  ||. ||  | .||.|.||.|||| .|.||   ||| | |.|  . |||||||   . .|||||
lldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfy

DECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSP---DIKTLDQIRTIERNQEIpHKGAFCDLVWSDPE-DVDTWAISPRGAGWLFGAKVTN
.||| .|     .     ||. | .. || ..|||.||||||   .  ||| .| |||..|  ...  .||.|.||   .  .    ||||  ||     
eecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrgagcgfgrdavl

EFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVF
. .   .| |.|||||.|..||.|.   ||||..||| || .  | |..|  
klcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmsc
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 64-309 3.1e-54 177.2 In-house 14-284 (302) alignment 
Range on Protein: 64-309
Range on HMM: 14-284/302.0
LCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQV-----------PDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHE
|.. | .|| .|...  .|.|||. ||||||| ||  .. .  .                ..|.||.||||. |.|  . ..|||  .| .  |||||||
lieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhe

SRQITQVYGFYDECQTKYGNAN---AWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERN-QEIPHKGAFCDLVWSDPEDVDTWAISP--
.. |   ||| .| ....|...    |.   .||  . .|||. |.|||||||.|| ...|..|. |.|  .|. .     ||...|| ||.. |. .  
tkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavsek

--------RGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIM
        ||   .|     ... .  ||||| |||| . ||.||. |.||.|..|||.|     |  ...
PkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 64-309 4.7e-54 176.6 In-house 15-285 (302) alignment 
Range on Protein: 64-309
Range on HMM: 15-285/302.0
LCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQV-----------PDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHE
|.. | .|| .|...  .|.|||. ||||||| ||  .. .  .                ..|.||.||||. |.|  . ..|||  .| .  |||||||
lieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhe

SRQITQVYGFYDECQTKYGNAN---AWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERN-QEIPHKGAFCDLVWSDPEDVDTWAISP--
.. |   ||| .| ....|...    |.   .||  . .|||. |.|||||||.|| ...|..|. |.|  .|. .     ||...|| ||.. |. .  
tkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavsek

--------RGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIM
        ||   .|     ... .  ||||| |||| . ||.||. |.||.|..|||.|     |  ...
PkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 68-312 3.5e-76 249.0 In-house 18-262 (280) alignment 
Range on Protein: 68-312
Range on HMM: 18-262/280.0
VCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQ
. ..|. .. .  | .||.||||.|||. ||  ||   .  ||.||.|.||.|||| . ||    ||| |...|... .||||||  .| . |||.||..
ckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevk

TKYGNAnAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPE-DVDTWAISPRGAGWLFGAKVTNEFVHINN
 .| .|  .    ...|.| ..||.  .|||.|||||.....||... . |  . ...    ||.|.||| .|  || ..||.  .|||.| .....  .
rrysla.lynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdltekld

LKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFK
. ||.| ||.| .||.|. | |||||.|||.|.    | |.... .
idliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivd
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 68-311 1.1e-66 218.2 In-house 18-261 (280) alignment 
Range on Protein: 68-311
Range on HMM: 18-261/280.0
VCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQ
|  ...||||.    .|. | |||| |. |.  ||   |.||. . .|.||.||||   .| .  |..|| .. ||| |||||||.  . ..|||| |||
veaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecq

TKYGNANAWRYCTkVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPED-VDTWAISPRGAGWLFGAKVTNEFVHINN
 ||| .  | . . .|. . ...|| ...||.||||||..  || || | |  |   .| . ||.|||| .  . |  | ||  ..||  | .. ..  .
ykygvglwwdfqs.cfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksle

LKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVF
. || ||||.|..||..|   .|.||.| |||| .  | |.....
idliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvcl
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 68-311 1.3e-63 208.1 In-house 15-260 (284) alignment 
Range on Protein: 68-311
Range on HMM: 15-260/284.0
VCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQ
..... ..  .  | .|. .|||||||| ||  ||   |    .||.|.||.|||| . |||   |.| |  .|... .||||||   | ..||||.|||
afsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecq

TKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAF-CDLVWSDPEDVD-TWAISPRGAGWLFGAKVTNEFVHIN
 .| .   .     ||  . ..||. ..|||.|||.|  .. . |.|.|.|  . |   ..  |..|||| ...  |    ||  ..||.    ...   
rrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrl

NLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVF
.. |. ||||.|..||.|. . .|||..||| || .  | |..|  
qidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyv
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 71-313 7.3e-74 241.5 In-house 23-265 (281) alignment 
Range on Protein: 71-313
Range on HMM: 23-265/281.0
LLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKY
.. ||...  . .|..| ||.|.|| || .||   |.||.. ..|.||.||||  |||..  |..|| ...||| |||||||  .. ..|||| ||.|||
ifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvecvtky

GNaNAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPE-DVDTWAISPRGAGWLFGAKVTNEFVHINNLKL
|  . |    . |. | ..|||....||.||||||.. .||..| . .  . ...|   ||.|.||. .|  |  | ||....|| .| ..     .. |
Ge.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvvddvckrlevel

ICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKD
| ||||.|..||. .   ||.||.|.||||    | |...  ..
iirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvde
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 76-330 6e-59 192.7 In-house 40-295 (307) alignment 
Range on Protein: 76-330
Range on HMM: 40-295/307.0
SNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGN--A
  .  .  |. | ||.|||| || ..|   |. |.| |.| ||.||||  |||.   |.. |  .|. | |||||||  .. . ||||.|| |   .   
kalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcge

NAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPE-DVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICR
. |    ..|. | ..|||  .|||.|||||| .  ||..|   .    | .|   |..|.||.  |  |  | ||.|. ||..| .. ..   ..|| |
eiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliir

AHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASimVFKDVNTREPKLFRAVPDSER
|||.. .||  .   ||.|..||| ||    |     |.|  .|   .|   ||.|| 
ahqmcfdgywvlsgrklitifsapmycnfyknagc..vlkvdetlgiqlvafvpesen
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 80-313 8.5e-71 231.2 In-house 34-270 (287) alignment 
Range on Protein: 80-313
Range on HMM: 34-270/287.0
PVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGnANAWRYC
 | .|.|..||||||. ||  .|   |. |...|.|.||.||||  |||   .|..|| ..| .. ||||||| ..| ..|||..| . |..  . ..  
eveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkeelkrkrq.erlykqf

TKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEI--PHKGAFCDLVWSDPE-DVDTWAIS-PRGAGWLFGAKVTNEFVHINNLKLICRAHQ
 .||. |.. | ....|||.|||.||..|.||....... .     ..|   ||.|.||| | .| ..   |.   .|| |. .....  ...|| |||.
ndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkkevddllkkldidlivrahe

LVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKD
...|||.|.||..||||.||| |. .  |.....| ..
vseeGyaflfdkrlvtvfsapyysgedtnlgavvvvsk
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 81-312 1.2e-63 207.9 In-house 41-276 (290) alignment 
Range on Protein: 81-312
Range on HMM: 41-276/290.0
VSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYgNANAWRYCT
| .|... ||||||. .| . |   |. |. ...|.||.||||  |||   .|. .| ... .. ||||||| |.. ..|||..|   |  ... |.   
veapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeelarkr.gsrlwkqyq

KVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQ--EIPHKGAFCDLVWSDPED--VDTWAIS-PRGAGWLFGAKVTNEFVHINNLKLICRAHQ
.||. |.. | ....|||.|||.|..|.. . ...... .     ..|   ||.|.||.    || |.   |.   .|| |. .....   |.|| |||.
dvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkglddllkklalslivrahe

LVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFK
. .||..|.||.|||||.||| |. .  |. .|.   
vkeegfnflfdkklvtvfsapyysgndtnlgaiatvs
subfamily_PPP7C_pd Subfamily PPP7C 81-220 1.1e-34 112.8 In-house 62-203 (383) alignment 
Range on Protein: 81-220
Range on HMM: 62-203/383.0
VSTPVTVCGDIHGQFYDLCELFR-TGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKY--GNANAWR
.|  ||||||.||.. ||. ..   |   .. .|.| |||||||  |.|    ||||   .|  . | |||||   .   |||  | ..||   ...  |
iskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilr

YCTKVFDMLTVAALIDEQILCVHGGLSpDIKTLDQIRTIERNQ
   .||  | .|.||||.|| ||||.| |.  |. .  |||..
lledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_PPP5C_pd Subfamily PPP5C 82-327 6.6e-79 258.2 In-house 64-311 (322) alignment 
Range on Protein: 82-327
Range on HMM: 64-311/322.0
STPVTVCGDIHGQFYDLCELFRTGGQVPD-TNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNaNAWRYCT
.. .|||||||||||||...|.  |.. .   |.| ||||||| .|.|.   ||..|  .|... | |||||| .. ..||| .|...|| . .     |
tkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakyte.kvadlft

KVFDMLTVAALIDEQILCVHGGL-SPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHE
.||..| .| .|.|..| ||||| | |  |||..|.|.||.. |..|....|.||||..    . | || |  ||  ||..|.. |||.|| |.|.. .|
evfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkee

GYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFK-DVNTREPKLFRAVPD
||... | ||.||.|||||| . || .... .. | .. . | | ||. 
GyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeaveh
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 82-312 2.5e-53 174.4 In-house 6-243 (263) alignment 
Range on Protein: 82-312
Range on HMM: 6-243/263.0
STPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANA----WR
 .|. .||| |||. ||  .| . |    |.|.|.||.|||| .|||    |..||   | .. ||||||| . | . |||. | . ..   .     . 
qapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvyn

YCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHK-GAFCDLVWSDPEDvDTWAISP---RGAGWLFGAKVTNEFVHINNLKLICRA
.  .||  . ..|.. ..|||.|||.|| .|.||.||.|    |  .     |||.|.|||  |.  . |   |    .|| |  .....  .. || ||
hfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidlivra

HQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFK
||.|  || |. | .|.||.||  |     | |...| .
hqvveygyaffadrrlitvfsasryqielcnyaavvvvn
Metallophos Calcineurin-like phosphoesterase 84-275 1.1e-43 142.9 Pfam-A 2-197 (200) alignment 
Range on Protein: 84-275
Range on HMM: 2-197/200.0
PVTVCGDIHGQFYDL----CELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYL--LALKAKWPDRITLLRGNHESRQITQVYGFYDECQ----------
...|.||.||...||     .|.. ... . ....|.||.|||| .|.||. .|  |.|| . |... ||||||||......|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------TKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIrtiernqeiphkgafcdlvwsdpedvdtwai
                       ..... .|.... ..|. |  .||.| .||..||.||.. .. |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGWLFGAKVTNEFVHINNLKLICRAHQ
    ...||| ......   ....|..|.|.
....gselfgpdalekllekygvdlvlrGHt
PPP_2 85-276 4.5e-82 267.5 In-house 1-197 (198) alignment 
Range on Protein: 85-276
Range on HMM: 1-197/198.0
VTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFD
||||||.|||..||..||..|...|...|.|.||.||||..|||....||||| ..|....||||||||.....||||..|...|.|..........||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

MLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDL-----VWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQL
.|..||||||..|.||||||..||.||||...||..|.|..|...||     .....|. ...| | ||||.|||..||.|... |.||||.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 85-276 2.6e-77 252.3 In-house 1-196 (197) alignment 
Range on Protein: 85-276
Range on HMM: 1-196/197.0
VTVCGDIHGQFYDL-CELFRTGGQVP-DTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKyGNANAWRYCTKV
|||.||||||..||  .|...||. . ...|.|.||.||||..|||....||||| . |....||||||||......|||..|...|  ..........|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIP-HKGAFCDLV-WSDPE-DVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQL
||.|..||||||..|.||||||.....||.|..|||..|.| ......||  ||||. . ...| | ||||.|||..||..|.. ||||||.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 85-276 8.2e-77 250.7 In-house 1-198 (199) alignment 
Range on Protein: 85-276
Range on HMM: 1-198/199.0
VTVCGDIHGQFYDL-CELFRTGGQVP-DTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKV
||||||.|||..|| ..||..||. . ...|.|.||.||||..|||....||||| . |....|||||||..|....|||..|...||...........|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIP-HKGAFCDLV-WSDPE-DVDT-WAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQL
||.|..||||||..|.|||||||.||...... |||..||| .||  .||. ||||. .... .. | ||||.||| .||..|.. ||||||.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 85-155 1.9e-07 23.9 In-house 12-78 (235) alignment 
Range on Protein: 85-155
Range on HMM: 12-78/235.0
VTVCGDIHGQFYDLCELFR--TGGQVPDTNYIFMGDFVDRGYYSLETFTYLlalkakWPDRITLLRGNHESRQ
. | ||.|| . .| ||.   .||. ..   ...||....|  |.|.  |.        |    ..||||   
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 110-312 1.2e-69 227.9 In-house 100-302 (317) alignment 
Range on Protein: 110-312
Range on HMM: 100-302/317.0
DTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNaNAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKT
  .|.|.||.|||| .|.|  . |.||| ..||...||||||||| . . |||| |.. .| . . .    ..| .| ..|.....|||.|||.| ..  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelld

LDQIRTIERNQEIPHKGAFCDLVWSDPE-DVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASI
|.|. ...|  .||  |  .||.|.||. .|.... |.|||| .||||  .||..  .|.|. ||||.|..||.|. | ||||..|||.|| .  |||..
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

MVFK
.  .
lsvd
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 112-310 8.9e-53 172.5 In-house 121-319 (339) alignment 
Range on Protein: 112-310
Range on HMM: 121-319/339.0
NYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYgNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLD
 |.|.||.|||| .|.|    | |||  .|||| ||||||||| .   |||| | . .| .|. .    ..|... ..|.|.. |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRTIERNQEIPHKGAFCDLVWSDPEDVD-TWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMV
|.  ..|  |||  | . || |.||.  .  .  | ||| ..||      |..  .|... | ||.| .||.|.   .|||..|||||| .  | |... 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs
subfamily_PPP7C_pd Subfamily PPP7C 229-311 9.7e-18 57.0 In-house 238-321 (383) alignment 
Range on Protein: 229-311
Range on HMM: 238-321/383.0
CDLVWSDPEDVD-TWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVF
 |..||||.  .  .. . ||.|  ||. ||.....  ||||. |.|.  .|||.|. |.|..|..|| ||     |  . . .
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvkl