Gene PFKFB1 in Homo sapiens

Synonym: F6PK, HL2K, PFRX, PFKFB1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP146_AA protein Get Run
HsapP146_AA_244-469 phosphatase_domain Get Run
Domains
Summary
100200300400MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHYHP1Curated phosphatase domainD6PF2KHis_Phos_1Pfam Domainsubfamily_PFKFB_pd(1)0035570(2)0039931(3)0053607(4)0036777(5)Subfamily
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 31-251 7.5e-107 345.8 Pfam-A 2-223 (223) alignment
Zeta_toxin Zeta toxin 36-154 8.7e-08 21.6 Pfam-A 11-123 (201) alignment
AAA_33 AAA domain 44-198 1.3e-11 35.0 Pfam-A 1-141 (143) alignment
KTI12 Chromatin associated protein KTI12 44-163 2.2e-06 17.0 Pfam-A 3-109 (270) alignment
AAA_17 AAA domain 45-160 6.4e-07 20.8 Pfam-A 2-100 (121) alignment
0037864 Phosphoglycerate mutase-like 245-437 9.4e-55 177.5 In-house 1-207 (211) alignment
subfamily_PFKFB_pd Subfamily PFKFB 246-441 1.7e-103 336.2 In-house 1-197 (198) alignment
0053607 Phosphoglycerate mutase-like 251-435 8.4e-57 183.9 In-house 1-185 (191) alignment
0043909 Phosphoglycerate mutase-like 251-435 4.4e-54 175.8 In-house 2-229 (249) alignment
0051064 Phosphoglycerate mutase-like 251-441 7.9e-54 175.4 In-house 3-232 (241) alignment
0049178 Phosphoglycerate mutase-like 251-436 5.9e-53 172.2 In-house 3-225 (243) alignment
0036777 Phosphoglycerate mutase-like 252-440 3.8e-55 179.4 In-house 3-230 (247) alignment
0036887 Phosphoglycerate mutase-like 252-436 3.7e-52 169.1 In-house 2-194 (202) alignment
subfamily_TIGAR_pd Subfamily TIGAR 253-407 2e-10 32.7 In-house 2-176 (222) alignment
0035570 Phosphoglycerate mutase-like 254-469 3.1e-65 211.8 In-house 2-217 (219) alignment
0039931 Phosphoglycerate mutase-like 254-466 7.7e-65 210.4 In-house 2-214 (219) alignment
0048955 Phosphoglycerate mutase-like 254-430 1.3e-51 168.1 In-house 3-218 (240) alignment
0050036 Phosphoglycerate mutase-like 254-425 1.2e-44 143.8 In-house 3-165 (171) alignment
His_Phos_1 Histidine phosphatase superfamily (branch 1) 254-400 6.9e-39 126.3 Pfam-A 2-158 (158) alignment
His_Phos_1 Histidine phosphatase superfamily (branch 1) 254-400 6.9e-39 126.3 In-house 2-158 (158) alignment
subfamily_PGAM_pd Subfamily PGAM 254-349 5.5e-11 34.2 In-house 3-107 (248) alignment
0053031 Phosphoglycerate mutase-like 254-386 2.3e-06 20.3 In-house 7-163 (342) alignment
subfamily_TFC7_pd Subfamily TFC7 269-405 1e-08 26.0 In-house 26-178 (255) alignment
subfamily_STS_pd Subfamily STS 272-402 1.2e-10 33.2 In-house 51-195 (245) alignment
subfamily_PGAM_pd Subfamily PGAM 353-412 1.4e-06 19.8 In-house 138-202 (248) alignment