Gene PFKFB1 in Homo sapiens

Synonym: F6PK, HL2K, PFRX, PFKFB1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP146_AA protein Get Run
HsapP146_AA_244-469 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 31-251 7.5e-107 345.8 Pfam-A 2-223 (223) alignment 
Range on Protein: 31-251
Range on HMM: 2-223/223.0
RGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSY-KNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAV
..|......||......||||||||||||.||||||.|.|..|||||.|.||||||.  ...||| ||| |||..|...|||||||...||..|||.||.
dqstvknlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvai

FDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMV
|||||||||||.|||.|..|...||.|.||.|.|. ||.|||..|||.|||| |...|....|||||.|.|| .|.|||.| |..|||||..|||....|
fDAtNttrerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgkslvv

NRVQDHIQSRTVYYLMNIHVTP
|.||...|||.||||.|||..|
nnvqgylqsrivyyllNihlkp
Zeta_toxin Zeta toxin 36-154 8.7e-08 21.6 Pfam-A 11-123 (201) alignment 
Range on Protein: 36-154
Range on HMM: 11-123/201.0
PQFtNSPTMVIMVGLPARGKTYISTKLTRYLNwiGTPTKVFNLGQYRREAVSYKNYEFflPDNMEALQIRKQCALAALKDVHNYLShEEGHVAVFDATNT
|.   .|..|...| |. |||.....| . |.  .. . ...  ..|..   |.. |    | .|| .. .. |    . .. ..  |.|   ... | .
peq.ekpkavllgGqpGAGKtslaellleela..agnivridaDelrkfhpeyrelek..kdpkeaseltqkdaselveklidral.ekgyniilegtlr

TRERRSLILQFAKEHGYKV
. .  . | . .|. ||||
spdkarkiarklkkagykv
AAA_33 AAA domain 44-198 1.3e-11 35.0 Pfam-A 1-141 (143) alignment 
Range on Protein: 44-198
Range on HMM: 1-141/143.0
MVIMVGLPARGKTYISTKLTRYLNWIGTPTKVfnlgqYRREAVS-----YKnyefflpdnmEALQIRKQCALAALKDVHNYLSHEEGhvAVFDATNTTRE
.|..||||. ||.. . .| . | ..   . .     .||.         .          .  . .|..  . .| .  .||.     ...||||..||
lvllvGlpGsGKstlaerllkklgyvrlsqdt.....lrrrlfgtdqqslt..........dytrvlkrlyqilnklarkalsagrs..vivdatnlsre

RRSLILQFAKEHGYKVFFIESICnDPGIIAENIRQVKLGSPDYIDcDREKVLEDFLKRIE
.|. ....||..|..|  .   . ..  .||.... .  . | ..   |..|...|.|.|
erarfvklakrlgvpvrivylev.peetlaeRlakRerngddrse.vpeealdrmlarfe
KTI12 Chromatin associated protein KTI12 44-163 2.2e-06 17.0 Pfam-A 3-109 (270) alignment 
Range on Protein: 44-163
Range on HMM: 3-109/270.0
MVIMVGLPARGKTYISTKLTRYLNWigtptkvfnlGQYRREAVSYKNYEfFLPDNMEALQIRKQCALAALKDVHNYLSHEegHVAVFDATNTTRERRSLI
.|.. |||. ||. .. .| ..|.            ...   .|  ... .  |. .  .  |.   .  ..|.  ||.|  .| . |..| ..  |  .
LvvltGlPssGKstvakeLakalee..........egrsvvvisdeslg.iekdsykdskkekalRsslrsavkrdLske..kvVIvDslnYikgfRyeL

LQFAKEHGYKVFFIESICND
   |||   ..  .. ... 
yclakeakttlcvvyvvapl
AAA_17 AAA domain 45-160 6.4e-07 20.8 Pfam-A 2-100 (121) alignment 
Range on Protein: 45-160
Range on HMM: 2-100/121.0
VIMVGLPARGKTYISTKLTRYLNWIgtptkVFNLGQY-RREAVSyKN-YEFFlpdnmEALQIRKQCALAALKDVHNylsHEEGHVAVFDAtntTRErRSL
.. .| |. ||......| ..|...     |..|... |.|..  .  ....     |. .. ..   | |..  .   .... . |.|    ..|   |
iaitGppGsGKsTlakeLaerlglp.....vlslddllreeglk.elddger.....eskdadadllaaildglaa...kkdtlswvidg...ale.vel

ILQFAkEHGYKVFFIESI
 | .. |..  ...  . 
dlrle.eadeiiyldapl
0037864 Phosphoglycerate mutase-like 245-437 9.4e-55 177.5 In-house 1-207 (211) alignment 
Range on Protein: 245-437
Range on HMM: 1-207/211.0
MNIHVTPRSIYLCRHGESELNIRGRIGG--DSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEAL----G---VPYEQWKALNEIDAGVCE
|....... .||.||||.| |. ||. |  |..|. .|...| ||.......|..   |..| ..|.|||||..    |   .|.|....|.|.| |..|
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgale

EMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAY
 .|.|||.|.||||.. . .|.| .|.|.|||..|.|.|..|...|| ..     |||||..|..|.|.||||.|. | .||..|..| ..|..|.   .
gltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddg

GCKVESI
|....|.
gwvlvsl
subfamily_PFKFB_pd Subfamily PFKFB 246-441 1.7e-103 336.2 In-house 1-197 (198) alignment 
Range on Protein: 246-441
Range on HMM: 1-197/198.0
NIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEH
|||..||.|||.|||||| | .||||||| |. ||..|| .||.||... ...|.||||..||||||||.||.|.||||||.|.|||.|...|||||.|.
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgltyeeikek

YPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELER-QENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNV
.||||. |..||||||||.|||||||||||||||.|||| |||||.|.||||.|.||||.|||| .||||||.|||||.||||||||||||.. |.|
fpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkldv
0053607 Phosphoglycerate mutase-like 251-435 8.4e-57 183.9 In-house 1-185 (191) alignment 
Range on Protein: 251-435
Range on HMM: 1-185/191.0
PRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEF
.. .||.||||.| |  ||. ||..|. .|...| |||......|..  .|..| ..|..||||..|.|.|....|.|||.|..| .|.||..|.||||.
mtrlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleelaekypeel

ALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVE
|.. .|.. ||.|.|||..|...|..|...|| ...||||..|..|.|.||||.|. . .||..|..| ..|..|..  .|....
aawlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlv
0043909 Phosphoglycerate mutase-like 251-435 4.4e-54 175.8 In-house 2-229 (249) alignment 
Range on Protein: 251-435
Range on HMM: 2-229/249.0
PRSIYLCRHGESELNIRGRIGG--DSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAE----ALG---VPYEQWKALNEIDAGVCEEMTYEE
.. .||.||||.| |  ||. |  ||.|. .|.. | ||.......||.  .|..| .||.|||||    .||   .|.|....|.|.| |..| .|..|
mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae

IQEHYPEEFALRDQ-----------------------------DKYRYRYPKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDK
| |.||||.... .                             |.. .|.|.|||..|.|.|..|...|| ..     .|||...|..|.|.||||.|. 
iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgl

SSDELPYLKCPLHTVLKLTPVAYGCKVE
| .....|..| .....|.. ..|..| 
sledilrlnlpngsitvlelddggkpvv
0051064 Phosphoglycerate mutase-like 251-441 7.9e-54 175.4 In-house 3-232 (241) alignment 
Range on Protein: 251-441
Range on HMM: 3-232/241.0
PRSIYLCRHGESELNIRGRIGG--DSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAE----ALG---VPYEQWKALNEIDAGVCEEMTYEE
.. .||.|||||| |  ||. |  |..|. .|...| ||.......||.  .|..| ..|.|||||    |||   .|......|.||| |..| .|.||
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee

IQEHYPEEFALRDQDKYRYRY-------------------------PKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKSSDE
|.|..|||......|.. .|.                         | |||..|...|..|.. || ..     .||||..|..|.|.||||.|. . .|
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglplee

LPYLKCPLHTVLKLTPVAYGCKVESIYLNV
|..|..| ..|..|.  ..|..|  ..|| 
llrlnlpngsvtvleldddgkrvvlvllnd
0049178 Phosphoglycerate mutase-like 251-436 5.9e-53 172.2 In-house 3-225 (243) alignment 
Range on Protein: 251-436
Range on HMM: 3-225/243.0
PRSIYLCRHGESELNIRGRIGG--DSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEAL----G---VPYEQWKALNEIDAGVCEEMTYEE
.. .||.||||.| |  ||. |  ||.|. .|.. | ||.... ..|.    |..| .||.|||||..    |   .|......|.|.| |..| .|..|
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkae

IQEHYPEEFALRDQDKYRYRY-----------------------PKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKSSDELP
|...||||.... .|.| .|.                       | |||..|...|..|...|| ..     ..|||..|..|.|.|||..|. . .||.
iaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleell

YLKCPLHTVLKLTPVAYGCKVES
.|..| ..|..|.   .|....|
rlnlpngsvtvlelddggwvlvs
0036777 Phosphoglycerate mutase-like 252-440 3.8e-55 179.4 In-house 3-230 (247) alignment 
Range on Protein: 252-440
Range on HMM: 3-230/247.0
RSIYLCRHGESELNIRGRIGG--DSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAE----ALG---VPYEQWKALNEIDAGVCEEMTYEEI
. .||.||||.| |. ||. |  |..|. .|...| ||. .....|.   .|..| ..|.|||||    |||   .|......|.|.| |..| .|..||
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei

QEHYPEEFALRDQDKYRYRY-------------------------PKGESYEDLVQRLEPVIMELERQ-----ENVLVICHQAVMRCLLAYFLDKSSDEL
.|.||||.... .|.| ||.                         | |||..|.|.|..|...|| ..     |||||..|..|.|.||||.|. | ...
aekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsledi

PYLKCPLHTVLKLTPVAYGCKVESIYLN
..|..| .....|.  ..| ..  ..||
lrlnlpngsitvleldddgklwvlesln
0036887 Phosphoglycerate mutase-like 252-436 3.7e-52 169.1 In-house 2-194 (202) alignment 
Range on Protein: 252-436
Range on HMM: 2-194/202.0
RSIYLCRHGESELNIRGRIGG--DSGLSVRGKQYAYALANFIQsqGISSLKVWTSHMKRTIQTAEAL----GVPYEQWKALNEIDAGVCEEMTYEEIQEH
. .||.||||.| |. ||. |  |..|. .|...| ||.....  |.    |..| ..|.|||||..    |.|......|.||| |..| .|.|||.|.
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiaek

YPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQ---ENVLVICHQAVMRCLLAYFLDKSSDELPYLK-CPLHTVLKLTPVAYGCKVES
||||.| . .|.| .|.|.|||..|.|.|......|| ..   .||||..|..|.|.||||.|. | ..|..|. .| ..|..|.  ..|.....
ypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvl
subfamily_TIGAR_pd Subfamily TIGAR 253-407 2e-10 32.7 In-house 2-176 (222) alignment 
Range on Protein: 253-407
Range on HMM: 2-176/222.0
SIYLCRHGESELNIRGRIGGD--SGLSVRGKQYAYALANFIQSQGISslKVWTSHMKRTIQTAEALG--------VPYEQWKALNEIDAGVCEEMTYEEI
.... ||||.| | .. . |   . || .| . | ..|.... ..|    . .|  .|. ||||.           . |. | | | . || | ....|.
ilivVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekin..yifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldel

QEHYPEEFalrdqDKYRYRYPKGESYEDLVQRLEPVIMEL-----ERQ------------ENVLVICHQAVMRCLLAYFLDK
.|    .      .  .   . ||| | | .|| . . ||     ...             .|||..|....| ||.... .
rellkaag.....nvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlhve
0035570 Phosphoglycerate mutase-like 254-469 3.1e-65 211.8 In-house 2-217 (219) alignment 
Range on Protein: 254-469
Range on HMM: 2-217/219.0
IYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALR
.||.||||.| |. ||. ||..|. ||...| ||.......||   .|..| ..|.|||||..|.|.|....|.|||.|..| .|..||.|.||||.|..
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaekypeelaaw

DQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPEN
 .|.|.||.|.|||..|.|.|..|...|||..|||||..|..|.|.||||.|. . .|...|..| ..|..|.. ..|.|.. ..||  .. ........
lrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvllndtshlelllelll

VDITREPEEALDTVPA
..... ..  | .|||
lslllvealllldvpa
0039931 Phosphoglycerate mutase-like 254-466 7.7e-65 210.4 In-house 2-214 (219) alignment 
Range on Protein: 254-466
Range on HMM: 2-214/219.0
IYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALR
.||.||||.| |  ||. |||.|. ||...| ||.......|..   |..| ..|.|||||..|.|.|....|.|||.|..| .|.|||.|.||||.|..
lyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeiaekypeelaaw

DQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPEN
 .|.|.||.|.|||..|.|.|..|...||...|||||..|..|.|.||||.|. | .|...|..| ..|..|.. ..|.......|. .  ...|... .
lrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvllnltshlddllrllllt

VDITREPEEALDT
.......  ||..
lelllllllalee
0048955 Phosphoglycerate mutase-like 254-430 1.3e-51 168.1 In-house 3-218 (240) alignment 
Range on Protein: 254-430
Range on HMM: 3-218/240.0
IYLCRHGESELNIRGRIGG--DSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAE----ALG---VPYEQWKALNEIDAGVCEEMTYEEIQE
.||.|||||| |  ||. |  |..|. .|...| ||.......||   .|..| ..|.|||||    |||   .|.... .|.|.| |..| .|..||.|
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeiae

HYPEEFALRDQDKYRYRY-------------------------PKGESYEDLVQRLEPVIMELE-----RQENVLVICHQAVMRCLLAYFLDKSSDELPY
..|||..|. .|.. .|.                         | |||..|...|..... ||      ...||||..|..|.|.||||.|. . .|...
kfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeilr

LKCPLHTVLKLTPVAY
|..| . |..|.   .
lnipngsvtvlelddg
0050036 Phosphoglycerate mutase-like 254-425 1.2e-44 143.8 In-house 3-165 (171) alignment 
Range on Protein: 254-425
Range on HMM: 3-165/171.0
IYLCRHGESELNIRGRIGG--DSGLSVRGKQYAYALANFIqsqgiSSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEefa
.||.||||.| |. ||. |  |..|. .|...| ||....     .   |..| ..|..||||....|......|.|.| |..| .|..||...|||   
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype...

lRDQDKYRYRYPKGESYEDLVQRLEPVIMELErqENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKL
 ...|......| |||..|...|. |.. ||   .||||..|..|.|.|||..|. | .|...|..| ..|| |
.wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 254-400 6.9e-39 126.3 Pfam-A 2-158 (158) alignment 
Range on Protein: 254-400
Range on HMM: 2-158/158.0
IYLCRHGESELNIRGRIGGDSG--LSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALG----VPYEQWKALNEIDAGVCEEMTYEEIQEHYP
.||.||||||.| .||. |.|   |. .|.. | .|.. ......   .|.|| .||.|||||.|     .|... ..|.|.|.|..|....||..|..|
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp

EEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELE----RQENVLVICHQAVMRCL
||.. ...||...|.|.|||..|...|..|...||     ..||||...|..|.|.|
eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 254-400 6.9e-39 126.3 In-house 2-158 (158) alignment 
Range on Protein: 254-400
Range on HMM: 2-158/158.0
IYLCRHGESELNIRGRIGGDSG--LSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALG----VPYEQWKALNEIDAGVCEEMTYEEIQEHYP
.||.||||||.| .||. |.|   |. .|.. | .|.. ......   .|.|| .||.|||||.|     .|... ..|.|.|.|..|....||..|..|
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp

EEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELE----RQENVLVICHQAVMRCL
||.. ...||...|.|.|||..|...|..|...||     ..||||...|..|.|.|
eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
subfamily_PGAM_pd Subfamily PGAM 254-349 5.5e-11 34.2 In-house 3-107 (248) alignment 
Range on Protein: 254-349
Range on HMM: 3-107/248.0
IYLCRHGESELNIRGRIGG--DSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEAL-------GVPYEQWKALNEIDAGVCEEMTYEEIQE
. | |||||||| . .. |  |  || .||. | .... .......  .|.||..||..||.|..        .| |.   |||   |. . .  .|. .
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaevak

HYPEE
.| ||
kyGee
0053031 Phosphoglycerate mutase-like 254-386 2.3e-06 20.3 In-house 7-163 (342) alignment 
Range on Protein: 254-386
Range on HMM: 7-163/342.0
IYLCRHG----ESELNIRGRI-----GGDSGLSVRGKQYAYALANFIQSQ---------GISSLKVWTSHMKRTIQTAEALGVPYEQwKALNEIDAGVCE
|.| |||    .| ..   ..      |.. |. .|.. ||.|  .. .            . ..|..| . ||.|.|.|.     . .   .|..   .
ivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfp.pegtpilnpllg

EMTYEEIQEHYPEEFALRD-------QDKYRYRYPKGESYEDLVQRLEPVIMELERQE
   .. ..|.  ... |.         ||.. .....| ...| .|..... .| .  
wqpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqklskgl
subfamily_TFC7_pd Subfamily TFC7 269-405 1e-08 26.0 In-house 26-178 (255) alignment 
Range on Protein: 269-405
Range on HMM: 26-178/255.0
RIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQT----AEALGVPYEQWKALNEI---D--AGVCEEMTYEEIQEHYPEEFAlRDQDKYR
 |  |  || || . |  ||..... ..    . .| ..| ..|    ||.| .|    . . |    |    . | ...|... ..|.    .| .   
gidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiPvyvdrGvgewykpdrrPvilePasnevlskffPsvis.ldyestl

YRYPKGESYEDLVQRLE---PV-----IMELERQENVLVICHQAVMRCLLAYFL
   .|||. |.| .|..   ||     . . . .| .|.. | | .  |   .|
tpsekgeteeelyertkkfwpvfidrvekkfknvetilivthaatkialGmsll
subfamily_STS_pd Subfamily STS 272-402 1.2e-10 33.2 In-house 51-195 (245) alignment 
Range on Protein: 272-402
Range on HMM: 51-195/245.0
GDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEqWKALNEIDAGVCEEMTYEEIQ-EHYPE-----EFALRDQDKYR-----Y
 |. |. ||.. |  |.. . ..||    .. | . |.||||.|.    .  |.  ... |..| . ... . .....     .| .. . .|.     .
sDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlsls

RYPKGESYEDLVQRLEPVIMEL----ERQENVLVICHQAVMRCLLA
.  ..||.|.|..| . |. |.    ....|.|.. | | .  |  
elkskeseeelyeRikkvvkeiiekvpedgniliVahaatldalsr
subfamily_PGAM_pd Subfamily PGAM 353-412 1.4e-06 19.8 In-house 138-202 (248) alignment 
Range on Protein: 353-412
Range on HMM: 138-202/248.0
RDQDKYRYRYPKGESYEDLVQRLEPVIME-----LERQENVLVICHQAVMRCLLAYFLDKSSDEL
| ... . ..|. || ...|.||.||. |     ......||.. |  ..|.|| .  . |... 
ryeelkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisdeai