Gene PFKFB2 in Homo sapiens

Synonym: PFK-2/FBPase-2, RP11-164O23.2, PFKFB2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP147_AA protein Get Run
HsapP147_AA_242-455 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 27-249 1.8e-106 344.6 Pfam-A 2-223 (223) alignment 
Range on Protein: 27-249
Range on HMM: 2-223/223.0
KCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEENGQIAV
..|... ..||...||..|||||||||.||||||||.|.||.|||||.| |||||||......|||.|||||.|.|...|| ||.|...||.||.||.|.
dqstvknlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvai

FDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKRIECYKVTYRPLDpDNYDKDLSFIKVINVGQRFL
|||||||||||..||.|.|.|..||.|.||||.|...|..|| |||.||||| ....|....|||||.|.|. .| ||| |. |..||.||||.||....
fDAtNttrerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyepld.deedeelsyIkvidvgkslv

VNRVQDYIQSKIVYYLMNIHVQP
||.||.|.||.|||||.|||..|
vnnvqgylqsrivyyllNihlkp
AAA_33 AAA domain 40-195 1.1e-12 38.5 Pfam-A 1-141 (143) alignment 
Range on Protein: 40-195
Range on HMM: 1-141/143.0
LIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVfnlgvYRREAVKsyksydfF-----RhdneEAMKIRKQCALVALEDVKAYLTEENGqiAVFDATNTTR
|....|||. ||......| . | .. . . .     .||.  .             .    .  . .|..  . .. .. .|.. .   ...||||..|
lvllvGlpGsGKstlaerllkklgyvrlsqdt.....lrrrlfg.......tdqqslt....dytrvlkrlyqilnklarkalsagrs..vivdatnlsr

ERRDMILNFAEQNSFKVFFVESVCDDpDVIAANiLEVKVSSPDYPERNRENVMEDFLKRIE
|.|. ....|.. ...|  |   ... ...|.. |. .  . |.. .  | .....|.|.|
eerarfvklakrlgvpvrivylevpe.etlaeR.lakRerngddrsevpeealdrmlarfe
KTI12 Chromatin associated protein KTI12 40-193 1.5e-08 24.1 Pfam-A 3-136 (270) alignment 
Range on Protein: 40-193
Range on HMM: 3-136/270.0
LIVMIGLPARGKTYVSKKLTRYLNWigvptKVFNLGVYRREAVKsYKSYDfFRHDNEEaMKIRKQcalvALEDVKAYLTEEngQIAVFDATNTTRERRDM
|.|. |||. ||. |.|.| ..|.      .  .  | . |...  .. . ... ..|  ..|..      ..||  |..|  .. . |..| ..  |  
LvvltGlPssGKstvakeLakalee.....egrsvvvisdeslg.iekds.ykdskke.kalRss....lrsavkrdLske..kvVIvDslnYikgfRye

ILNFAEQNSFKVFFVESVCDDPDVIAANilevkvSSPDYPERNRENVMEDFLKR
. . | . . ..  |. |..  ...  |      .. . .|.  ....|. ..|
Lyclakeakttlcvvyvvapletlvkwn......eereekekyekelleaLiqR
AAA_17 AAA domain 41-133 2.3e-07 22.3 Pfam-A 2-78 (121) alignment 
Range on Protein: 41-133
Range on HMM: 2-78/121.0
IVMIGLPARGKTYVSKKLTRYLNWIgvptkVFNLGV-YRREAVKSYKsYDFFRHdNEEAMKIRKQCalvaLEDVKAyltEENGQIAVFDAtntT
|. .| |. ||....|.| ..|...     |..|.  .|.|..|  . .....  ... ... ..     |.. .|   .. ... |.|    .
iaitGppGsGKsTlakeLaerlglp.....vlslddllreeglkeld.dgeres.kdadadllaai....ldglaa...kkdtlswvidg...a
DUF421 Protein of unknown function (DUF421) 99-134 4.5e-06 12.7 Pfam-A 34-68 (99) alignment 
Range on Protein: 99-134
Range on HMM: 34-68/99.0
MKIRKQcALVALEDVKAYLTEENGQIAVFDATNTTR
...|..     |.||..   | |||. |.  .. . 
eeLRek.gieslsdVelaiLEtnGqlsvikkeekkp
0037864 Phosphoglycerate mutase-like 243-434 1.6e-53 173.4 In-house 1-206 (211) alignment 
Range on Protein: 243-434
Range on HMM: 1-206/211.0
MNIHVQPRTIYLCRHGESEFNLLGKIGG--DSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESL----G---VPYEQWKILNEIDAGVCE
|.........||.||||.|.|. |.. |  |..|. .|.. |.||...| .. ..   |..| |.|.||||| .    |   .|.|... |.|.| |..|
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgale

EMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELERQ-----GNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAY
 .|..||...||||.. . . .| .|.|||||..|.|.|..|...|| ..     .||||.||..|.|.||||.|. . .||..|..| .....|.   .
gltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddg

GCKVET
|.....
gwvlvs
subfamily_PFKFB_pd Subfamily PFKFB 244-440 1.2e-100 326.9 In-house 1-198 (198) alignment 
Range on Protein: 244-440
Range on HMM: 1-198/198.0
NIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKR
|||..||.|||.|||||| |  |.||||| |. ||...|..|.||..|.....|.||||.||||||||| ||.|.||||.|.|.|||.|...|| ||...
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgltyeeikek

YPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELER-QGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVE
.||||. |...|| ||||.||||.||||||||||.|||| | |||.|.||||.|.||||.||| |.|||||..||||..||||||||||||..||.||
fpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkldve
0053607 Phosphoglycerate mutase-like 249-433 3.6e-56 181.9 In-house 1-185 (191) alignment 
Range on Protein: 249-433
Range on HMM: 1-185/191.0
PRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEF
....||.||||.|.|. |.. ||..|. .|.. |.|| ..| |. ..  .|..| |.|..|||| .|.|.|... |.|||.|..| .|..|....||||.
mtrlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleelaekypeel

ALRDQEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVE
|.. . .. ||.|||||..|...|..|...|| ..|||||..|..|.|.||||.|. . .||..|..| .....|..  .|....
aawlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlv
0036777 Phosphoglycerate mutase-like 249-438 1.1e-54 177.9 In-house 2-230 (247) alignment 
Range on Protein: 249-438
Range on HMM: 2-230/247.0
PRTIYLCRHGESEFNLLGKIGG--DSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAE----SLG---VPYEQWKILNEIDAGVCEEMTYAE
....||.||||.|.|. |.. |  |..|. .|.. |.||...| |....  .|..| |.|.|||||     ||   .|..... |.|.| |..| .|.||
mkrlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkae

IEKRYPEEFALRDQEKYLYRY-------------------------PGGESYQDLVQRLEPVIMELERQ-----GNVLVISHQAVMRCLLAYFLDKGADE
|...||||.... . .| ||.                         |||||..|.|.|..|...|| ..     .||||.||..|.|.||||.|. . ..
iaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsled

LPYLRCPLHTIFKLTPVAYGCKVETIKLN
...|..| ..|..|.  ..| ..  . ||
ilrlnlpngsitvleldddgklwvlesln
0043909 Phosphoglycerate mutase-like 249-434 7.4e-54 175.0 In-house 2-230 (249) alignment 
Range on Protein: 249-434
Range on HMM: 2-230/249.0
PRTIYLCRHGESEFNLLGKIGG--DSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAE----SLG---VPYEQWKILNEIDAGVCEEMTYAE
....||.||||.|.|. |.. |  ||.|. .|.. |.||...| |..|   .|..| |||.|||||     ||   .|.|... |.|.| |..| .|.||
mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae

IEKRYPEEFALRDQ-----------------------------EKYLYRYPGGESYQDLVQRLEPVIMELERQ-----GNVLVISHQAVMRCLLAYFLDK
|...||||.... .                             ...|.|.|||||..|.|.|..|...|| ..     ||||...|..|.|.||||.|. 
iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgl

GADELPYLRCPLHTIFKLTPVAYGCKVET
. .....|..| ..|..|.. ..|..| .
sledilrlnlpngsitvlelddggkpvvv
0049178 Phosphoglycerate mutase-like 249-434 3.9e-53 172.8 In-house 3-225 (243) alignment 
Range on Protein: 249-434
Range on HMM: 3-225/243.0
PRTIYLCRHGESEFNLLGKIGG--DSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESL----G---VPYEQWKILNEIDAGVCEEMTYAE
....||.||||.|.|. |.. |  ||.|. .|.. |.||...| |....   |..| |||.||||| .    |   .|..... |.|.| |..| .|.||
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkae

IEKRYPEEFALRDQEKYLYRY-----------------------PGGESYQDLVQRLEPVIMELERQ-----GNVLVISHQAVMRCLLAYFLDKGADELP
|...||||.... . .| .|.                       |||||..|...|..|...|| ..     ..|||..|..|.|.|||..|. . .||.
iaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleell

YLRCPLHTIFKLTPVAYGCKVET
.|..| .....|.   .|.....
rlnlpngsvtvlelddggwvlvs
0051064 Phosphoglycerate mutase-like 249-438 7.2e-53 172.2 In-house 3-231 (241) alignment 
Range on Protein: 249-438
Range on HMM: 3-231/241.0
PRTIYLCRHGESEFNLLGKIGG--DSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAE----SLG---VPYEQWKILNEIDAGVCEEMTYAE
....||.||||||.|. |.. |  |..|. .|.. |.||...| .. |   .|..| |.|.|||||     ||   .|..... |.||| |..| .|..|
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee

IEKRYPEEFALRDQEKYLYRY-------------------------PGGESYQDLVQRLEPVIMELERQ-----GNVLVISHQAVMRCLLAYFLDKGADE
|....|||......... .|.                         |||||..|...|..|.. || ..     .||||.||..|.|.||||.|. . .|
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglplee

LPYLRCPLHTIFKLTPVAYGCKVETIKLN
|..|..| .....|.  ..|..|  . ||
llrlnlpngsvtvleldddgkrvvlvlln
0036887 Phosphoglycerate mutase-like 249-434 2.4e-51 166.4 In-house 1-194 (202) alignment 
Range on Protein: 249-434
Range on HMM: 1-194/202.0
PRTIYLCRHGESEFNLLGKIGG--DSGLSVRGKQFAQALRKFLEeqEITDLKVWTSQLKRTIQTAESL----GVPYEQWKILNEIDAGVCEEMTYAEIEK
....||.||||.|.|. |.. |  |..|. .|.. |.|| ..|   ...   |..| |.|.||||| .    |.|..... |.||| |..| .|..||..
mtrlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiae

RYPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELERQ---GNVLVISHQAVMRCLLAYFLDKGADELPYLR-CPLHTIFKLTPVAYGCKVET
.||||.| . . .| .|.|||||..|.|.|......|| ..   |||||.||..|.|.||||.|. . ..|..|| .| .....|.  ..|.....
kypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvl
0035570 Phosphoglycerate mutase-like 251-455 1e-62 203.6 In-house 1-205 (219) alignment 
Range on Protein: 251-455
Range on HMM: 1-205/219.0
TIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFAL
..||.||||.|.|| |.. ||..|. ||.. |.|| ..| .. |.  .|..| |.|.||||| .|.|.|... |.|||.|..| .|..||...||||.|.
rlyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaekypeelaa

RDQEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEAVNTHRDKPT
. . .| ||.|||||..|.|.|..|...|||...||||.||..|.|.||||.|. ...|...|..| ... .|.. ..|.|.. . ||  .. ... ...
wlrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvllndtshlelllell

NNFPK
.... 
llsll
0039931 Phosphoglycerate mutase-like 251-449 5.7e-62 201.1 In-house 1-199 (219) alignment 
Range on Protein: 251-449
Range on HMM: 1-199/219.0
TIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFAL
..||.||||.|.|. |.. |||.|. ||.. |.|| ..| .. .    |..| |.|.||||| .|.|.|... |.|||.|..| .|..||...||||.|.
rlyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeiaekypeelaa

RDQEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEAVNTHRDKP
. . .| ||.|||||..|.|.|..|...||....||||.||..|.|.||||.|. . .|...|..| ... .|.. ..|...... |. .  ...| ..
wlrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvllnltshlddllrlll
0048955 Phosphoglycerate mutase-like 251-428 6e-51 165.9 In-house 2-218 (240) alignment 
Range on Protein: 251-428
Range on HMM: 2-218/240.0
TIYLCRHGESEFNLLGKIGG--DSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAE----SLG---VPYEQWKILNEIDAGVCEEMTYAEIE
..||.||||||.|. |.. |  |..|. .|.. |.||...| .. |   .|..| |.|.|||||     ||   .|....  |.|.| |..| .|..||.
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia

KRYPEEFALRDQEKYLYRY-------------------------PGGESYQDLVQRLEPVIMELE-----RQGNVLVISHQAVMRCLLAYFLDKGADELP
...|||..|. .... .|.                         |||||..|...|..... ||      ...||||.||..|.|.||||.|. . .|..
ekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeil

YLRCPLHTIFKLTPVAY
.|..| . ...|.   .
rlnipngsvtvlelddg
0050036 Phosphoglycerate mutase-like 251-423 4.2e-44 142.1 In-house 2-165 (171) alignment 
Range on Protein: 251-423
Range on HMM: 2-165/171.0
TIYLCRHGESEFNLLGKIGG--DSGLSVRGKQFAQALRKFLeeqeiTDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEef
..||.||||.|.|| |.. |  |..|. .|.. |.||...|     .   |..| |.|..|||| ...|..... |.|.| |..| .|..||...|||  
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype..

alRDQEKYLYRYPGGESYQDLVQRLEPVIMELErqGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKL
  ... .. ...|||||..|...|. |.. ||   |||||..|..|.|.|||..|. ...|...|..| .... |
..wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 251-398 5.2e-38 123.5 Pfam-A 1-158 (158) alignment 
Range on Protein: 251-398
Range on HMM: 1-158/158.0
TIYLCRHGESEFNLLGKIGGDSG--LSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLG----VPYEQWKILNEIDAGVCEEMTYAEIEKRY
..||.||||||.|  |.. |.|   |. .|.. |..| | |.....   .|.||.|||.|||||.|     .|... . |.|.|.|..|.....|.....
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

PEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELE----RQGNVLVISHQAVMRCL
|||.. ....|. .|.|.|||..|...|..|...||     ...|||..||..|.|.|
peeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 251-398 5.2e-38 123.5 In-house 1-158 (158) alignment 
Range on Protein: 251-398
Range on HMM: 1-158/158.0
TIYLCRHGESEFNLLGKIGGDSG--LSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLG----VPYEQWKILNEIDAGVCEEMTYAEIEKRY
..||.||||||.|  |.. |.|   |. .|.. |..| | |.....   .|.||.|||.|||||.|     .|... . |.|.|.|..|.....|.....
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

PEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELE----RQGNVLVISHQAVMRCL
|||.. ....|. .|.|.|||..|...|..|...||     ...|||..||..|.|.|
peeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
subfamily_PGAM_pd Subfamily PGAM 251-347 1.7e-10 32.6 In-house 2-107 (248) alignment 
Range on Protein: 251-347
Range on HMM: 2-107/248.0
TIYLCRHGESEFNLLGKIGG--DSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAES-------LGVPYEQWKILNEIDAGVCEEMTYAEIE
.. | ||||||.|   |. |  |  || .||. |... | |......  .|.||.|||..||.|          .| |.   |||   |. . .  ||. 
klvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaeva

KRYPEE
|.| ||
kkyGee
subfamily_TFC7_pd Subfamily TFC7 251-398 3.3e-06 17.8 In-house 2-173 (255) alignment 
Range on Protein: 251-398
Range on HMM: 2-173/255.0
TIYLCRHGESEF--------NLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTA----ESLGVPYEQ-WKILNEID----AGVCE
|||..|||  .         . |  |  |  || || . |. | ..|.. ..    . .| |.| ..|.    | | .|      . . .       . |
tiyiarhGyrsnwlpkgpypdpltgidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiPvyvdrGvgewykpdrrPvile

EMTYAEIEKRYPEEFAlRDQEKYLYRYPGGESYQDLVQRLE---PV-----IMELERQGNVLVISHQAVMRCL
 ... ...| .|.    .| |  |   . ||. ..| .|..   ||     . . . .. .|...| | .  |
PasnevlskffPsvis.ldyestltpsekgeteeelyertkkfwpvfidrvekkfknvetilivthaatkial
subfamily_TIGAR_pd Subfamily TIGAR 252-403 6.9e-11 34.2 In-house 3-174 (222) alignment 
Range on Protein: 252-403
Range on HMM: 3-174/222.0
IYLCRHGESEFNLLGKIGGD--SGLSVRGKQFAQALRKFLEEQEITdlKVWTSQLKRTIQTAESL--------GVPYEQWKILNEIDAGVCEEMTYAEIE
... ||||.|||  . . |   . || .| . |... |.|....|.   . .| |.|. ||||          . . |. |.| | . || | ....|..
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekin..yifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr

KRYPEEFalrdqEKYLYRYPGGESYQDLVQRLEPVIMEL-----ERQ------------GNVLVISHQAVMRCLLAYFL
.    .      .      .|||| . | .|| . . ||     ...             .|||.||....| ||....
ellkaag.....nvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlh
subfamily_STS_pd Subfamily STS 269-398 2.4e-10 32.2 In-house 50-193 (245) alignment 
Range on Protein: 269-398
Range on HMM: 50-193/245.0
GGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEqWKILNEIDAGVCEEMTYAEIE-KRYPE-----EFALRDQEKY-----L
  |. |. ||.. |. | . | |..|.   .. |   |.||||. .    .  ||  ... |..| . ... . .....     .| .. .|.|     |
ksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlsl

YRYPGGESYQDLVQRLEPVIMEL----ERQGNVLVISHQAVMRCL
..   .||...|..| . |. |.    ...||.|...| | .  |
selkskeseeelyeRikkvvkeiiekvpedgniliVahaatldal