Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
0049178 | Phosphoglycerate mutase-like | 1-228 | 9.2e-72 | 233.7 | In-house | 1-224 (243) | alignment | ||
Range on Protein: 1-228
Range on HMM: 1-224/243.0
MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNK
| ..|.|.||||. ||.|.|. ||.|..|.. |.|.|.. |..|...|. ||....| ||||.|.. .|.|.....||||...||.||..| |.||.|
mmmtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltk
AETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNIskDRRYADLteDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGL
||.|||..|..|..||..||..||.......... . ||..||| |.|| |||.|..||.||...| . .....||.||. |||...| ....| ||
aeiaakypeelvawwrdpydarppalllldlllpll..drlladl..dllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllgl
SEEAIMELNLPTGIPIVYELDKNLKPIK
. |... ||||.| ..|.||| .. ..
pleellrlnlpngsvtvlelddggwvlv
|
|||||||||
0051064 | Phosphoglycerate mutase-like | 1-230 | 2.2e-70 | 229.5 | In-house | 1-228 (241) | alignment | ||
Range on Protein: 1-230
Range on HMM: 1-228/241.0
MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNK
|. ..|.|.||||| ||.|.|. ||.|..|.. |.|.|.. |..|.|.|. ||....| .|||.|.. ...|.....|||| ..||.|...| |.||..
mmmkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltl
AETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYsnISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGL
.|.|.|..|..|...|...||.||..|...... . |.|||.|..|.|| |||.|..||.||...| . .....||.||. .||...| ....| ||
eeiaekfpeelvawlrdpldvrppllelldlll..llldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllgl
SEEAIMELNLPTGIPIVYELDKNLKPIKPM
. |... ||||.| ..|.|||...|... .
pleellrlnlpngsvtvleldddgkrvvlv
|
|||||||||
0037864 | Phosphoglycerate mutase-like | 3-231 | 6.2e-64 | 207.4 | In-house | 7-208 (211) | alignment | ||
Range on Protein: 3-231
Range on HMM: 7-208/211.0
AYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAE
..|.|.||||. ||.|.|. ||.|..|.. |.|.|.. |.||.|.|..||....| .|||.|.. .|.|.....|||....||.||..| | ||...|
mtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgalegltlee
TAAKHGEAQVKIWRRSYDVPPPPMepdhpfysniskdrryadltedqlpscESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSE
.|.|..|..|...|..||..||.. |||.|..||.||...| . ...|.|..||. .||..|| ....| |||
iaekypeelvawlrdpydfrppgg...........................EsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsl
EAIMELNLPTGIPIVYELDKNLKPIKPMQ
|....||||.| ..|.|||....... ..
eellrlnlpngsvtvlelddggwvlvsln
|
|||||||||
subfamily_PFKFB_pd | Subfamily PFKFB | 3-115 | 7.6e-12 | 37.1 | In-house | 6-109 (198) | alignment | ||
Range on Protein: 3-115
Range on HMM: 6-109/198.0
AYKLVLIRHGESAWNLENRFSGwyDADLSPAGHEEAKRGGQALRDAGY-EFdICFTSVQKRAIRTLWTVlDAIDQMWLPvvrtwrLNERHYGGLTGLNKA
....| ||||| .| ..| .| |..|.. |.| ||. .. ... . |. . .|| ||.|.| .. .. .. | |.|. | . ||.
preiylvRhGeseknkkgrigg..dseLterGveyakklakfikeenlkel.rvwtselkrtiqTaell.glpkeqwka......LdeldaGkcdgltye
ETAAKHGEAQVKIW
|. |..| .
eikekfpeefkerk
|
|||||||||
subfamily_PGAM_pd | Subfamily PGAM | 4-251 | 1.5e-124 | 406.2 | In-house | 1-248 (248) | alignment | ||
Range on Protein: 4-251
Range on HMM: 1-248/248.0
YKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAET
.||||.|||||..| ||.|.||.||.||..|.||||. |.||..|..||||..|||.|||..||...|...||...||..||||||||||.||||||||.
iklvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaev
AAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEE
|.|.||..||||||||||.|||.| |......|.|||||..|.|..||..||||....|.||..||||...|||||||||.|||||.|...|.|||.|.|
akkyGeekvkiwRRsydvkPPpveedkeyfkeinkdrryeelkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisde
AIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGK
||.||.||||||.|||||.||||.|..|||||||.|.||.||||.|||
aikeldlptgiplvyeldenlkpvkkkqflgDeesvkkaaeavanqgk
|
|||||||||
0043909 | Phosphoglycerate mutase-like | 4-242 | 2.8e-79 | 258.2 | In-house | 3-243 (249) | alignment | ||
Range on Protein: 4-242
Range on HMM: 3-243/249.0
YKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAET
..|.|.||||. ||.|.|| ||.|..|.. |.|.|.. |.||...|. ||....| ||||.|.. .|.......|||....||.||..| |.||.|||.
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkaei
AAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYA--DLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLS
|.|..|..|...||||||.||..|...... ....| ..| |. |..| .|||.|..||.||...| . ...|.|..||| |||..|| ....| |||
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgls
EEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKA
|.|..||||.|...|.|||...||.. ...|.| . ...
ledilrlnlpngsitvlelddggkpvvvlvllndtshleal
|
|||||||||
0036777 | Phosphoglycerate mutase-like | 4-250 | 1.9e-77 | 252.3 | In-house | 3-246 (247) | alignment | ||
Range on Protein: 4-250
Range on HMM: 3-246/247.0
YKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAET
..|.|.||||. ||.|.|| ||.|..|.. |.|.||. |..|...|. ||....| .|||.|.. .|.|.....||||...||.||.|| |.||.|||.
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei
AAKHGEAQVKIWRRSYDVPPPPMEPDHPFYsnISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEE
|.|..|..|..||..||..||..|...... .....|||.|. |.|| .|||.|..||.||...| . ...|.|..||. .||..|| ....|.||| |
aekypeelvawwrdpydyrppllelllell..lldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsle
AIMELNLPTGIPIVYELDKNLKpIKPMQFLGDEETVRKAMEAVAAQG
.|..||||.|...|.|||.. | . ...|.| . .....||||..|
dilrlnlpngsitvleldddgk.lwvleslndtshlelgleavadfg
|
|||||||||
0048955 | Phosphoglycerate mutase-like | 5-236 | 2.3e-70 | 229.3 | In-house | 2-231 (240) | alignment | ||
Range on Protein: 5-236
Range on HMM: 2-231/240.0
KLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||| ||.|.|. ||.|..|.. |.|.|.. |..|.|.|. ||....| .|||.|.. ...|.....|||| ..||.||..| |.||...|.|
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia
AKHGEAQVKIWRRSYDVPPPPMEPDHPFYsnISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEA
.|..|..|...|...||.||..|...... .. |.|||.|.||.|| |||.|..||.|....| . ...|.||.||. .||...| ....| ||. |.
ekfpeelvlwlrdpldvrppllelldell..llldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglplee
IMELNLPTGIPIVYELDKNLKPIKPMQFLGDE
|..||.|.| ..|.|||..|.... ...|.|.
ilrlnipngsvtvlelddglvslndtshlddl
|
|||||||||
0035570 | Phosphoglycerate mutase-like | 5-224 | 3.8e-55 | 178.9 | In-house | 1-179 (219) | alignment | ||
Range on Protein: 5-224
Range on HMM: 1-179/219.0
KLVLIRHGESAWNLENRFSGwyDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVldaidqmWLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||. ||||.|. | |..|.. |.|.|.. |.||.| |..||....| .|||.|.. . .|||....||.|...| | ||...|.|
rlyLvRHGetewnlegrlqg..dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltldeia
AKHGEAQVKIWRRSYDVPPppmepdhpfysniskdrryadltedqlPSCESLKDTIARALPFWNEEivpqiKEGKRVLIAAHGNSLRGIVKHLEGLSEEA
.|..|......|..||..| | |||.|..||.||...| ..|..||. .||...| ....| ||. |.
ekypeelaawlrdpydyrp...........................pggEsladvvaRvlpaleel.....edgenvlvVsHggvirallayllglplee
IMELNLPTGIPIVYELDKNL
|. ||||.| ..|.|||..
ilrlnlpngsvtvleldggg
|
|||||||||
0039931 | Phosphoglycerate mutase-like | 5-228 | 1.1e-53 | 174.1 | In-house | 1-183 (219) | alignment | ||
Range on Protein: 5-228
Range on HMM: 1-183/219.0
KLVLIRHGESAWNLENRFSGwyDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVldaidqmWLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||. ||.|.|. | |..|.. |.|.|.. |..|.| |..||....| .|||.|.. . .|||....||.|...| | ||...|.|
rlyLvRHGetewnvegrlqg..dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltleeia
AKHGEAQVKIWRRSYDVPPppmepdhpfysniskdrryadltedqlPSCESLKDTIARALPFWNEEiVPqikeGKRVLIAAHGNSLRGIVKHLEGLSEEA
.|..|......|..||..| | |||.|..||.||...| .. |..||. .||...| ....| ||| |.
ekypeelaawlrdpydyrp...........................pggEsladvvaRvlpaleel.la....genvlvVsHggvirallayllglslee
IMELNLPTGIPIVYELDKNLKPIK
|. ||||.| ..|.|||.. ..
ilrlnlpngsvtvlelddggwvlv
|
|||||||||
0036887 | Phosphoglycerate mutase-like | 5-225 | 4.3e-53 | 172.1 | In-house | 3-190 (202) | alignment | ||
Range on Protein: 5-225
Range on HMM: 3-190/202.0
KLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRdaGYEFDICFTSVQKRAIRTLWTVLDAIDqmwLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||. ||.|.|. |..|..|.. |.|.|.. |..|. |. ||....| .|||.|.. ...|.. |||....||.|...| | ||...|.|
rlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealg...lpvivdprlrEidfgalegltleeia
AKHGEAQVKIWRRSYDVPPPPMepdhpfysniskdrryadltedqlpscESLKDTIARALPFWNEEIVPQikEGKRVLIAAHGNSLRGIVKHLEGLSEEA
.|..|......|..||..||.. |||.|..||.|....| . .. .|..||. .||..|| ....| ||| |.
ekypeelaawlrdpydfrppgg...........................EsladvvaRvlaaleellarl..dggnvlvVsHggvlrallayllglsled
IMELN-LPTGIPIVYELDKNLK
.. |. ||.| ..|.|||..
llrlrklpngsvtvlelddggw
|
|||||||||
0050036 | Phosphoglycerate mutase-like | 5-222 | 1.6e-51 | 166.1 | In-house | 2-169 (171) | alignment | ||
Range on Protein: 5-222
Range on HMM: 2-169/171.0
KLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALrdagyEFDICFTSVQKRAIRTLWTVLdaidqmwLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||. ||||.|| ||.| .|.. |...|.. |..| .||....| ..||..|.. .| |||....||.||..| ..||...|.|
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil.......lpvivdprLrErdfGawegltldeia
AKHGEaqvkiwrrsydvppppmepdhpfysniskdrRYADLTEDQLPSCESLKDTIARALPFWNEEIvpqikegKRVLIAAHGNSLRGIVKHLEGLSEEA
||..| ...|| ...| |||.|..||.||...| . ..||..|||...| ....| ||| |.
akype...............................wlldlldlappggEsladvlaRvlpaleell.......gnvlvvaHggvirallalllglslee
IMELNLPTGIPIVYELDK
|..|.||.|...|.|||.
ilrlelpngsvlvleldd
|
|||||||||
0053607 | Phosphoglycerate mutase-like | 5-225 | 1.5e-50 | 163.6 | In-house | 3-182 (191) | alignment | ||
Range on Protein: 5-225
Range on HMM: 3-182/191.0
KLVLIRHGESAWNLENRFSGwyDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVldaidqmWLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||. ||.|.|. | |..|.. |.|.|.. ...|.. |..||....| .||..|.. . .|||....||.|...| ..||...|.|
rlyLvRHGetewnaegrlqg..dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.......glpvevdprlrEidfgdwegltleela
AKHGEAQVKIWRRSYDVPPppmepdhpfysniskdrryadltedqlPSCESLKDTIARALPFWNEEIVpqikeGKRVLIAAHGNSLRGIVKHLEGLSEEA
.|..|......|...|..| | |||.|..||.||...| . |..||. |||...| ....| ||. |.
ekypeelaawlrdpldyrp...........................pggEsladvaaRvlpaleella.....ggnvlvVaHggvirallayllglplee
IMELNLPTGIPIVYELDKNLK
.. ||||.| ..|.|||..
llrlnlpngsvtvlelddggw
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 5-191 | 8e-43 | 139.1 | Pfam-A | 1-156 (158) | alignment | ||
Range on Protein: 5-191
Range on HMM: 1-156/158.0
KLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDqmwLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||| || |.|..|| |. |.. |.|.|.. |..|..|. ..| ..|| |||| |.. .|. .| .|. ...||.||..| . ||.|.|..
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevk
AKHGEAQVKIWRRSYDVPPPpmepdhpfysniskdrryadltedqlpSCESLKDTIARALPFWNEEIVpQIKEGKRVLIAAHGNSLR
....|.. |..|..... || |||.|...|. ||..| | . ..|..||| .||..||
eefpeeyekwkrdkkefrpp...........................egesladvyeRvapfleelie.akdkgenvlivsHggvlr
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 5-191 | 8e-43 | 139.1 | In-house | 1-156 (158) | alignment | ||
Range on Protein: 5-191
Range on HMM: 1-156/158.0
KLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDqmwLPVVRTWRLNERHYGGLTGLNKAETA
.|.|.||||| || |.|..|| |. |.. |.|.|.. |..|..|. ..| ..|| |||| |.. .|. .| .|. ...||.||..| . ||.|.|..
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevk
AKHGEAQVKIWRRSYDVPPPpmepdhpfysniskdrryadltedqlpSCESLKDTIARALPFWNEEIVpQIKEGKRVLIAAHGNSLR
....|.. |..|..... || |||.|...|. ||..| | . ..|..||| .||..||
eefpeeyekwkrdkkefrpp...........................egesladvyeRvapfleelie.akdkgenvlivsHggvlr
|
|||||||||
subfamily_PGAM5_pd | Subfamily PGAM5 | 5-77 | 3.8e-06 | 18.2 | In-house | 3-70 (189) | alignment | ||
Range on Protein: 5-77
Range on HMM: 3-70/189.0
KLVLIRHGESAWNLENRfsgwyDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQM
.|.|.|||. . .. . |.. | . |.. |. |.. ...|.. .| ||. | .. ...
hlilvrhgqyvldddsd.....kkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdv
|
|||||||||
subfamily_TIGAR_pd | Subfamily TIGAR | 6-105 | 8.6e-17 | 53.5 | In-house | 3-101 (222) | alignment | ||
Range on Protein: 6-105
Range on HMM: 3-101/222.0
LVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDagYEFDICFTSVQKRAIRTLWTVLDAIDQ-MWLPVVRTWRLNERHYGGLTGLNKAETA
|...||||. .| |. . | | ||. | | ||| .. | . ... |.| ..|| .| .| |. . ..|.|. || || || . | ...|
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsn..ekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr
A
.
e
|
|||||||||
0053031 | Phosphoglycerate mutase-like | 6-116 | 7.3e-06 | 18.7 | In-house | 7-106 (342) | alignment | ||
Range on Protein: 6-116
Range on HMM: 7-106/342.0
LVLIRHG----ESAWNLENRFS---GWYDADLSPAGHEEAKRGGQALRDA---------GYEFDICFTSVQKRAIRTLWTVLDAI--DQMWL---PVVRt
||.||| .| ..|. . .. . .|.| | |.|. |..||. .. ..| . |.. . .| .. .. . | ..
ivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllg.
wrlnerhyggltglnkaetaakhgeaqvkiwR
...............................w
|