Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
0049178 | Phosphoglycerate mutase-like | 1-224 | 2e-70 | 229.3 | In-house | 1-220 (243) | alignment | ||
Range on Protein: 1-224
Range on HMM: 1-220/243.0
MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNK
| . ||..|||||..||.|.|..||.|..|.|.| |.|.. ......... ||..|.| |||||.|...||.......||||...||.||..| |.||.|
mmmtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltk
AETAAKHGEEQVKIWRRSFDIPPPPMDEKHPYYNSIskERRYAGLKPgeLPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGM
||.|||..||.|..||...|..||.. ..... . |..|.| . || |||.|..||.||...| . .....||.||. |||...| ....| |.
aeiaakypeelvawwrdpydarppalllldlllpll..drlladldl..lpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllgl
SDQAIMELNLPTGIPIVYELNKEL
...... ||||.| ..|.||. ..
pleellrlnlpngsvtvlelddgg
|
|||||||||
0051064 | Phosphoglycerate mutase-like | 1-228 | 2.3e-68 | 222.9 | In-house | 1-226 (241) | alignment | ||
Range on Protein: 1-228
Range on HMM: 1-226/241.0
MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNK
|.. ||..||||||.|| |.|..||.|..|.|.| |.|.. .....|. . ||..|.| |.|||.|...|... ....|||| ..||.|...| |.||..
mmmkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltl
AETAAKHGEEQVKIWRRSFDIPPPPMDEKHPYYnsISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGM
.|.|.|..||.|...|...|..||... .... . ..|||||... || |||.|..||.||...| . .....||.||. .||...| ....| |.
eeiaekfpeelvawlrdpldvrppllelldlll..llldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllgl
SDQAIMELNLPTGIPIVYELNKELKPTK
...... ||||.| ..|.||....|. .
pleellrlnlpngsvtvleldddgkrvv
|
|||||||||
0037864 | Phosphoglycerate mutase-like | 2-228 | 1.6e-63 | 206.1 | In-house | 2-205 (211) | alignment | ||
Range on Protein: 2-228
Range on HMM: 2-205/211.0
A----THRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTG
. . ||..|||||..||.|.|..||.|..|.|.| |.|.. ..|..|....||..|.| |.|||.|...||.. ....|||....||.||..| | |
slnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgaleg
LNKAETAAKHGEEQVKIWRRSFDIPPPPMdekhpyynsiskerryaglkpgelptcESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHL
|...|.|.|..||.|...|...|..||.. |||.|..||.||...| . ...| |..||. .||..|| ....|
ltleeiaekypeelvawlrdpydfrppgg...........................EsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayl
EGMSDQAIMELNLPTGIPIVYELNKELKPTK
|.|......||||.| ..|.||...... .
lglsleellrlnlpngsvtvlelddggwvlv
|
|||||||||
subfamily_PGAM5_pd | Subfamily PGAM5 | 3-72 | 3.3e-06 | 18.4 | In-house | 1-65 (189) | alignment | ||
Range on Protein: 3-72
Range on HMM: 1-65/189.0
THRLVMVRHGESTWNQENRfcgwfDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILD
| .|..||||. . .... . |.|.| . |.. | .|. ...|.. ..| . ||. | |.
trhlilvrhgqyvldddsd.....kkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiisk
|
|||||||||
0043909 | Phosphoglycerate mutase-like | 4-242 | 2e-76 | 248.8 | In-house | 3-243 (249) | alignment | ||
Range on Protein: 4-242
Range on HMM: 3-243/249.0
HRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAET
||..|||||..||.|.||.||.|..|.|.| |.|.. ..|.|.... ||..|.| |||||.|...||.. ....|||....||.||..| |.||.|||.
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkaei
AAKHGEEQVKIWRRSFDIPPPPMDEKHPYYNSISKERRYA--GLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMS
|.|..||.|...|||.|..||...| .... ... ..| . .| .|||.|..||.||...| . ...| |..||| |||..|| ....| |.|
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgls
DQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVRKA
...|..||||.|...|.||....||.. ...|.| . ...
ledilrlnlpngsitvlelddggkpvvvlvllndtshleal
|
|||||||||
0036777 | Phosphoglycerate mutase-like | 4-250 | 5.6e-76 | 247.5 | In-house | 3-246 (247) | alignment | ||
Range on Protein: 4-250
Range on HMM: 3-246/247.0
HRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAET
||..|||||..||.|.||.||.|..|.|.| |.||. ....|.... ||..|.| |.|||.|...||.. ....||||...||.||.|| |.||.|||.
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei
AAKHGEEQVKIWRRSFDIPPPPMDEKHPYYnsISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMSDQ
|.|..||.|..||...|..||.... .... ... .||| |. .|| .|||.|..||.||...| . ...| |..||. .||..|| ....|.|.|..
aekypeelvawwrdpydyrppllelllell..lldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsle
AIMELNLPTGIPIVYELNKELKpTKPMQFLGDEETVRKAMEAVAAQG
.|..||||.|...|.||... | . ...|.| . .....||||..|
dilrlnlpngsitvleldddgk.lwvleslndtshlelgleavadfg
|
|||||||||
0036887 | Phosphoglycerate mutase-like | 4-223 | 4.5e-53 | 172.1 | In-house | 2-188 (202) | alignment | ||
Range on Protein: 4-223
Range on HMM: 2-188/202.0
HRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKdaKMEFDICYTSVLKRAIRTLWAILDGTDqmwLPVVRTWRLNERHYGGLTGLNKAET
||..|||||..||.|.|..|..|..|.|.| |.|.. ..... .. ||..|.| |.|||.|...|... . |||....||.|...| | ||...|.
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealg...lpvivdprlrEidfgalegltleei
AAKHGEEQVKIWRRSFDIPPPPMdekhpyynsiskerryaglkpgelptcESLKDTIARALPFWNEEIVPQikAGKRVLIAAHGNSLRGIVKHLEGMSDQ
|.|..||.....|...|..||.. |||.|..||.|....| . .. .|..||. .||..|| ....| |.|..
aekypeelaawlrdpydfrppgg...........................EsladvvaRvlaaleellarl..dggnvlvVsHggvlrallayllglsle
AIMELN-LPTGIPIVYELNKE
... |. ||.| ..|.||...
dllrlrklpngsvtvlelddg
|
|||||||||
subfamily_PFKFB_pd | Subfamily PFKFB | 4-113 | 1.1e-14 | 46.4 | In-house | 7-107 (198) | alignment | ||
Range on Protein: 4-113
Range on HMM: 7-107/198.0
HRLVMVRHGESTWNQENRFCGwfDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAIlDGTDQMWLPvvrtwrLNERHYGGLTGLNKAET
. ...|||||| .|...| | |.||.|.|.| ||. || ||. ... . .|| |||.|.| .. . .. | |.|. | . ||. |.
reiylvRhGeseknkkgrigg..dseLterGveyakklakfikeenlkelrvwtselkrtiqTaell.glpkeqwka......LdeldaGkcdgltyeei
AAKHGEEQVK
|..|| .
kekfpeefke
|
|||||||||
subfamily_PGAM_pd | Subfamily PGAM | 5-251 | 1.1e-124 | 406.6 | In-house | 2-248 (248) | alignment | ||
Range on Protein: 5-251
Range on HMM: 2-248/248.0
RLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETA
.||..|||||..|.||.||||.||.|||||.||||. .||.|.|..||||.||||||||..||..||. .||...||..||||||||||.||||||||.|
klvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaeva
AKHGEEQVKIWRRSFDIPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMSDQA
.|.|||.|||||||.|..|||..|...|...|.|.|||. ||. |||..||||....|.||..||||...||.||||||.|||||.|...|.|||.||.|
kkyGeekvkiwRRsydvkPPpveedkeyfkeinkdrryeelkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisdea
IMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVRKAMEAVAAQGK
|.||.||||||.||||...|||.|..|||||||.|.||.||||.|||
ikeldlptgiplvyeldenlkpvkkkqflgDeesvkkaaeavanqgk
|
|||||||||
0048955 | Phosphoglycerate mutase-like | 5-236 | 3.7e-68 | 222.1 | In-house | 2-231 (240) | alignment | ||
Range on Protein: 5-236
Range on HMM: 2-231/240.0
RLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETA
||..||||||.|| |.|..||.|..|.|.| |.|.. .....|. . ||..|.| |.|||.|...|... ....|||| ..||.||..| |.||...|.|
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia
AKHGEEQVKIWRRSFDIPPPPMDEKHPYYnsISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMSDQA
.|..||.|...|...|..||... .... .. ..|||.|... || |||.|..||.|....| . ...|.||.||. .||...| ....| |.....
ekfpeelvlwlrdpldvrppllelldell..llldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglplee
IMELNLPTGIPIVYELNKELKPTKPMQFLGDE
|..||.|.| ..|.||...|.. . ...|.|.
ilrlnipngsvtvlelddglvslndtshlddl
|
|||||||||
0035570 | Phosphoglycerate mutase-like | 5-224 | 4.6e-55 | 178.6 | In-house | 1-179 (219) | alignment | ||
Range on Protein: 5-224
Range on HMM: 1-179/219.0
RLVMVRHGESTWNQENRFCGwfDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAIldgtdqmWLPVVRTWRLNERHYGGLTGLNKAETA
||..|||||..|| |.|..| |..|.|.| |.|.. ..|..| ...||..|.| |.|||.|...| .|||....||.|...| | ||...|.|
rlyLvRHGetewnlegrlqg..dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltldeia
AKHGEEQVKIWRRSFDIPPppmdekhpyynsiskerryaglkpgelPTCESLKDTIARALPFWNEEivpqiKAGKRVLIAAHGNSLRGIVKHLEGMSDQA
.|..||.....|...|..| | |||.|..||.||...| . |..||. .||...| ....| |.....
ekypeelaawlrdpydyrp...........................pggEsladvvaRvlpaleel.....edgenvlvVsHggvirallayllglplee
IMELNLPTGIPIVYELNKEL
|. ||||.| ..|.||...
ilrlnlpngsvtvleldggg
|
|||||||||
0039931 | Phosphoglycerate mutase-like | 5-224 | 4.6e-54 | 175.3 | In-house | 1-179 (219) | alignment | ||
Range on Protein: 5-224
Range on HMM: 1-179/219.0
RLVMVRHGESTWNQENRFCGwfDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAIldgtdqmWLPVVRTWRLNERHYGGLTGLNKAETA
||..|||||..|| |.|..| |..|.|.| |.|.. ....|| ...||..|.| |.|||.|...| .|||....||.|...| | ||...|.|
rlyLvRHGetewnvegrlqg..dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltleeia
AKHGEEQVKIWRRSFDIPPppmdekhpyynsiskerryaglkpgelPTCESLKDTIARALPFWNEEiVPqikaGKRVLIAAHGNSLRGIVKHLEGMSDQA
.|..||.....|...|..| | |||.|..||.||...| .. |..||. .||...| ....| |.|...
ekypeelaawlrdpydyrp...........................pggEsladvvaRvlpaleel.la....genvlvVsHggvirallayllglslee
IMELNLPTGIPIVYELNKEL
|. ||||.| ..|.||...
ilrlnlpngsvtvlelddgg
|
|||||||||
0050036 | Phosphoglycerate mutase-like | 5-222 | 1.5e-50 | 163.0 | In-house | 2-169 (171) | alignment | ||
Range on Protein: 5-222
Range on HMM: 2-169/171.0
RLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIkdakmEFDICYTSVLKRAIRTLWAILdgtdqmwLPVVRTWRLNERHYGGLTGLNKAETA
||..|||||..|| |.||.|| | .|.|.| ..|.. .... .||..|.| |.||..|...|| |||....||.||..| ..||...|.|
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil.......lpvivdprLrErdfGawegltldeia
AKHGEeqvkiwrrsfdippppmdekhpyynsiskerRYAGLKPGELPTCESLKDTIARALPFWNEEIvpqikagKRVLIAAHGNSLRGIVKHLEGMSDQA
||..| ... | .| |||.|..||.||...| . ..||..|||...| ....| |.|...
akype...............................wlldlldlappggEsladvlaRvlpaleell.......gnvlvvaHggvirallalllglslee
IMELNLPTGIPIVYELNK
|..|.||.|...|.||..
ilrlelpngsvlvleldd
|
|||||||||
0053607 | Phosphoglycerate mutase-like | 5-223 | 2.3e-50 | 163.0 | In-house | 3-180 (191) | alignment | ||
Range on Protein: 5-223
Range on HMM: 3-180/191.0
RLVMVRHGESTWNQENRFCGwfDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAIldgtdqmWLPVVRTWRLNERHYGGLTGLNKAETA
||..|||||..|| |.|..| |..|.|.| |.|.. |..... ..||..|.| |.||..|...| .|||....||.|...| ..||...|.|
rlyLvRHGetewnaegrlqg..dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.......glpvevdprlrEidfgdwegltleela
AKHGEEQVKIWRRSFDIPPppmdekhpyynsiskerryaglkpgelPTCESLKDTIARALPFWNEEIVpqikaGKRVLIAAHGNSLRGIVKHLEGMSDQA
.|..||.....|...|..| | |||.|..||.||...| . |..||. |||...| ....| |.....
ekypeelaawlrdpldyrp...........................pggEsladvaaRvlpaleella.....ggnvlvVaHggvirallayllglplee
IMELNLPTGIPIVYELNKE
.. ||||.| ..|.||...
llrlnlpngsvtvlelddg
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 5-191 | 2.1e-43 | 141.0 | Pfam-A | 1-156 (158) | alignment | ||
Range on Protein: 5-191
Range on HMM: 1-156/158.0
RLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDqmwLPVVRTWRLNERHYGGLTGLNKAETA
||..|||||| ||.|.|..|| |..|.||| |.|.. .|..|.|. ..| .||| ||||| |....|.. | .|. ...||.||..| . ||.|.|..
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevk
AKHGEEQVKIWRRSFDIPPPpmdekhpyynsiskerryaglkpgelpTCESLKDTIARALPFWNEEIVpQIKAGKRVLIAAHGNSLR
....||. |..|..... || |||.|...|. ||..| | . . |..||| .||..||
eefpeeyekwkrdkkefrpp...........................egesladvyeRvapfleelie.akdkgenvlivsHggvlr
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 5-191 | 2.1e-43 | 141.0 | In-house | 1-156 (158) | alignment | ||
Range on Protein: 5-191
Range on HMM: 1-156/158.0
RLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDqmwLPVVRTWRLNERHYGGLTGLNKAETA
||..|||||| ||.|.|..|| |..|.||| |.|.. .|..|.|. ..| .||| ||||| |....|.. | .|. ...||.||..| . ||.|.|..
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevk
AKHGEEQVKIWRRSFDIPPPpmdekhpyynsiskerryaglkpgelpTCESLKDTIARALPFWNEEIVpQIKAGKRVLIAAHGNSLR
....||. |..|..... || |||.|...|. ||..| | . . |..||| .||..||
eefpeeyekwkrdkkefrpp...........................egesladvyeRvapfleelie.akdkgenvlivsHggvlr
|
|||||||||
subfamily_TIGAR_pd | Subfamily TIGAR | 5-105 | 1.3e-19 | 62.8 | In-house | 2-101 (222) | alignment | ||
Range on Protein: 5-105
Range on HMM: 2-101/222.0
RLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDakMEFDICYTSVLKRAIRTLWAILDGTD-QMWLPVVRTWRLNERHYGGLTGLNKAET
.|..|||||. .|.|. . | | ||||| | ||| || ... .... ..| |.|| .| .|| . ..|.|. || || || . | ...|
ilivVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsn..ekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldel
AA
.
re
|
|||||||||
subfamily_Dicty-HP1-1_pd | Subfamily Dicty-HP1-1 | 6-66 | 2.5e-07 | 20.7 | In-house | 3-66 (210) | alignment | ||
Range on Protein: 6-66
Range on HMM: 3-66/210.0
LVMVRHGESTWNQE-NRF--CGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRT
. ..||||||.|.. | . ||| |.|.| ..|.. .. ... . .. .| | ||. |
vyiirhgestfnkaynekvdpylfdarlteegkkqanelsenvekllqdvelvisspltraldt
|