Gene ILKAP in Homo sapiens

Synonym: ILKAP2, ILKAP3, PP2C-DELTA, ILKAP

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily ILKAP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP168_AA protein Get Run
HsapP168_AA_97-391 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 98-391 1.3e-74 243.5 In-house 12-291 (295) alignment 
Range on Protein: 98-391
Range on HMM: 12-291/295.0
CKASSVIFGLKGYVAERKGEREEMQDAHVILNDITEECRPpsslitrVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKG--DVISVEKTVKRCLLDTF
.. || .. |. .||  .| |....||.... ..    ..       ...|.||||||| .|...|...|...|.. . |      . . .....| ..|
lllsslllllrvgvasdqGrrksneDavlvvlnllslled.......lllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaf

KHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNeesqkhAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGD
...|||.|..| ...  .  |.||...| ..| ||.||.|||||.|.| .       .. |...|.|....||.||..||| |..|||.||| |.|..||
laadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrng......elvqltvdhkpvnelererilsaggavshgrvngvlavtRalGd

GQYK--------RCGVTSVPDIRRCQLT-PNDRFILLACDGLFKVFTPEEAVNFILSCLED--EkiqtregksaadarYEAACNRLANKAVQRGSADNVT
 ..|        . .|...||..  .|| ..| |.|||.|||..|...||.|... |.|.   .              .|.|...|.. |..||| ||.|
fdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld..............leeaaeeLvdlAlargsrDNiT

VMVVRIG
|.|||..
vvvvrln
subfamily_ILKAP_pd Subfamily ILKAP 105-390 5.4e-148 484.9 In-house 3-292 (293) alignment 
Range on Protein: 105-390
Range on HMM: 3-292/293.0
FGLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLK
. |||..|||||||||||||||||.|..|..| ..||..||||.||||||.| |||.|||..||.....|.||.|| . ||..|.||.|.||.|||||||
yklkgayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLk

QASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCGVT
.||..||.||||||||.||..||.||.||||||.|.|.|..||..|.|...|.|.|.|..||||.|||||||.|||||||||||||||||||..||.||.
laskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlGvi

SVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDE----KIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVRI
|.||...|.||.||.|..||||||.|||. .|.|.|||..||||    ||...|.||....|.|.||||||..||.|||.|||||..|.|
stPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvki
subfamily_PPM1A_pd Subfamily PPM1A 107-389 7.5e-59 192.4 In-house 12-279 (282) alignment 
Range on Protein: 107-389
Range on HMM: 12-279/282.0
LKGYVAERKGEREEMQDAHVILNDITeEcrppsslITRVSYFAVFDGHGGIRASKFAAQNLHQNLIR--KFPK-GDVISVEKTVKRCLLDTFKHTDEEFL
|.  |.. .| | || |||..  ... .       ..  |.|||||||.| ...|.....|..|...  .. .     | ...||  | . | ..||.  
lrygvssmqgwrvemEDahtvvaslg.a.......lkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeair

KQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNeesqkhAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKR---
.. ...| | | ||||..||  .. |.|||||||||.||| .      .|  |...| |.. .|. ||..|||.|  .|| | | |||..|| .||.   
elstdlktadksGsTavtvlvsekhliianlGDsRavlcrng......kaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeee

-----CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQT-RegksaadaryeaaCNRLANKAVQRGSADNVTVMVVR
       |...|... .. . .| |..|||||.. | . ||.|... . ||  .  .               ...| .|| ..|| ||..|.|| 
kkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev.............akalvdkalekgsrDNlsvlvvl
PP2Cc_SM00332 110-388 4.3e-75 245.6 In-house 14-274 (274) alignment 
Range on Protein: 110-388
Range on HMM: 14-274/274.0
YvAERKGEREEMQDAHVILNDITeecrppssLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDV-IsvEKTVKRCLLDTFKHTDEEFLKQASS
. .. .|.|..|.||||. .|            .....|.||||||| ...||....|...|...  | .     |. |...| . |. ||||.|....|
k.ssmqgwrksmeDahvvvvdlv........eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel..eddveealkkaflstdeeileeeqs

QKP-AWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEesqkhaALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKR------C
...  .. ||||...| ... ||.||.|||||.||| ..      |..||..|.| . .|| ||.|||| |..||| |.|.|||..||...|.       
kelenalsGstavvallkkedlyvanvGDSravlcrngk......avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknkklkep

GVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEkiqtregksaADARYEAACNRLANKAVQR-GSADNVTVMVV
..|. ||.  ..||..|.|..||.|||. |....|.|... ..|. .          .. ....|...|...| .| ||.||.||.||
yitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg..........ktndpqeaaelldeeairrggseDniTvvvv
0049733 PP2C-like 111-391 4.1e-58 189.3 In-house 7-234 (235) alignment 
Range on Protein: 111-391
Range on HMM: 7-234/235.0
VAERKGE-REEMQDAHVIlnditeecrppsslitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKgdviSVEKTVKRCLLDTFKHTDEEFLKQASSQ
.| ..|  |....||...                 ...|||.||||| .|...|...|...|.. . .      . .....| ..|....|..|..| ..
aasdigrvrkvneDavlv................glllfavaDGhgghaagevasellvetllellle....lllldleealrkaflaaneallelalas

KPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEesqkhaALSLSKEHNPTQYEERMRIQKAGGNVrdgRVLGVLEVSRSIGDGQYKrcgvtsvPDI
.. .  |.||...| ... ||.||.|||||.|.| ..      .. |...|.|.. .||.||..||| |   ||.|.| ..|..|| ..|       ||.
pelagmgtTavvalldggklyvanvGDsrayllrdgk......lvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.......pdv

RRCQLTPNDrFILLACDGLFKVFTPEEAVNFILScledekiqtregksaadARYEAACNRLANKAVQRGSADNVTVMVVRIG
....|.|.| |.|||.|||..|...||.|... |                   .|.|..||.. |..||. ||.||.|||..
tvlelepgd.flllasDGlwdvlsdeeivdllrs.................ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_PPM1G_pd Subfamily PPM1G 111-205 1.8e-10 33.4 In-house 23-102 (473) alignment 
Range on Protein: 111-205
Range on HMM: 23-102/473.0
VAERKGEREEMQDAHVILNDITEECrppsslitrvSYFAVFDGHGGIRASKFAAQNLHQNLirkfpKGDVISVEKTVKRCLLDTFKHTDEEFLKQ
..  .| |... |||  . |..|..          | |||.|||||   .|. |..| . |     | ..   |  |...| ..| . ||.  ..
asamqGwrvsqEDahncitdldedt..........slfavyDGHGGkevakyvakklpdll.....kaqkgykegdvekaleeaflalDeklkae
PPM_PTC7 112-383 2.6e-63 206.9 In-house 6-259 (259) alignment 
Range on Protein: 112-383
Range on HMM: 6-259/259.0
AERKGEREEMQDAHVILNDITEEcrppsSLITRVSYFAVFDGHGGIRASKFAAQNLHQ--NLIRKFPKGDvisvekTVKRCLLDTFKH--TDEEFLKQAS
 . .| |..| |||..|..   .     |    |..||||||||| .|.|.|...|..  .. . |....       ....| ..|    ||||. ... 
safqgfrksmedahialanless.....sgkdsvaffavfdghggreaakyarehleeilkerksfeele......klekalrksflaldtdeelkssea

SQkPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESqkhaaLSLSKEHNPTQYEERMRIQKAGGNVR---DGRVLGVLEVSRSIGDGQYKR----
..   .. ||||...| ... ||.||.|||||.||| ...        |.. |.|.  .|| ||..|||.|    .||| |||.|||..|| ..|.    
nt.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav.....kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpkete

-CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEkiqtregksaadaRYEAACNRLANKAVQRGSADNV
 . |.. |||   .....| |..||.|||. |....||| .. |.|...               . |...|...|..|||.||.
eqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.............dpmeaaeklvdeaiargsedni
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 112-390 2.2e-44 144.6 In-house 11-253 (255) alignment 
Range on Protein: 112-390
Range on HMM: 11-253/255.0
AERKGEREEMQDAHVILNDITEECRppSslitrvSYFAVFDGHGGIRASKFAAQNLHQNLIRKfpkgdvISVEKT-VKRCLLDTFKHTDEEFlkqasSQK
..  | |  |.|  ||     ..    .       |.|.|||||| .|.|||...|.. |  .      . ....  ...| ...|...  .     |..
sdmiGrrptmedelviyGsfrdksd..e......dyyalfdGhgGraaakfaseelykilael......ldlnnanPvkslkkaykeistqi.....ser

PaWKDGSTATCVLAVDNILYIANLGDSRAILCryneeSQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDG----RVLGVLEVSRSIGDgQYKRCGVTSV
|    |.||. || ...  ||||.||||..||      ..  |  || .|.|.. .|. ||...||.|  .    || | | |||..||  .    |.. 
p.kfiGttaasvliiedkvyianvGdsrvvlc.....qkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGd.sflePfvvpd

PDIR-RCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKiqtregksaadaryeaACNRLANKAVQRGSADNVTVMVVRI
||.    . . .|.|..|||||.. . . ||||. ...  . ||                |...| ..| ..|| ||..|.|...
PdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdpek................aaeklrdlayssGstdnisvivikl
subfamily_PPM1D_pd Subfamily PPM1D 112-281 2.2e-29 95.5 In-house 7-174 (309) alignment 
Range on Protein: 112-281
Range on HMM: 7-174/309.0
AERKGEREEMQDAHVILNDITEECRppsslITRVSYFAVFDGHGGIRASKFAAQNLHQNLIR--KFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASS-
. ..|.|. |.|  .|  . .|. .        |...||||||||  |.||| ..| ... .  ||   .  .| . ...  |.| .   ..  . .   
eadqGgrkymeDvvaivleeeesae.....elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktk

QKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDG
..     |.||..|.  .. ||.|. |||...|   ... .|  |  | |.| | . ||. ||...||.| . 
sgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak
PP2C Protein phosphatase 2C 113-383 7.1e-66 215.4 Pfam-A 7-255 (255) alignment 
Range on Protein: 113-383
Range on HMM: 7-255/255.0
ERKGEREEMQDAHVILNDITEEcrppsSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLI--RKFPKGDvisvekTVKRCLLDTFKH-TDEEFLKQASSQ
| .| |..| |||..|..  ..     |   .|..||||||||| .|.|.|...|.. |   ..|....       |...| ..|   ||||. ... ..
elqgarksmedahialknleks.....sgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelksskant

kPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESqkhaaLSLSKEHNPTQYEERMRIQKAGGNVR-DGRVLGVLEVSRSIGDGQYKR---CGVTS
   .| ||||...| ... ||.||.|||||.||| ...       .|.. | |.. .|| ||..||| |   ||| |.|.|||..|| ..|.   . |..
.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.....keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsa

VPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKiqtregksaadaRYEAACNRLANKAVQRGSADNV
 ||..  .||..| |..||.|||. |....||| .. |.|...|              . |...|...|..|||.||.
ePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk............spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 113-383 7.1e-66 215.4 In-house 7-255 (255) alignment 
Range on Protein: 113-383
Range on HMM: 7-255/255.0
ERKGEREEMQDAHVILNDITEEcrppsSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLI--RKFPKGDvisvekTVKRCLLDTFKH-TDEEFLKQASSQ
| .| |..| |||..|..  ..     |   .|..||||||||| .|.|.|...|.. |   ..|....       |...| ..|   ||||. ... ..
elqgarksmedahialknleks.....sgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelksskant

kPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESqkhaaLSLSKEHNPTQYEERMRIQKAGGNVR-DGRVLGVLEVSRSIGDGQYKR---CGVTS
   .| ||||...| ... ||.||.|||||.||| ...       .|.. | |.. .|| ||..||| |   ||| |.|.|||..|| ..|.   . |..
.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.....keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsa

VPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKiqtregksaadaRYEAACNRLANKAVQRGSADNV
 ||..  .||..| |..||.|||. |....||| .. |.|...|              . |...|...|..|||.||.
ePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk............spmeaaeelvdeaiargsedni
subfamily_PPM1E_pd Subfamily PPM1E 113-388 1.4e-56 184.6 In-house 10-260 (265) alignment 
Range on Protein: 113-388
Range on HMM: 10-260/265.0
ERKGEREEMQDAHVILNDITEECRPpsSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGD--VisvektvkRCLLDTFKHTDEEFLKQAssQK
  |..|  | | ||.|.|. |      .  .  ..|||||||||. |.|.||..||..|.|.    .  .        . | ..||.|||.||..|  ..
avknkrrkmEDrhvaledlnelfel..kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa........ealkeafkltDerflqka..er

PAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEERMRIQKAGGNVR---DGRVLGVLEVSRSIGDGQYKRCgVTSVP
 ..| |||| .||   . ||.| ||||.|.|.|      |  |..| | |.| . .|. ||..||| |      || ||| |||.||| ..|.  |.. .
eklksGstavvvliekdqlyvaWlGDsqallvr......kgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpy.vsgea

DIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQtregksaadarYEAACNRLANKAVQRGSADNVTVMVV
|. ...|. .. ...||||||. |...||.|. . . |.|.. .           .. . . | ..| ..||.||.||.||
dvaeveldgseeylilacDGlwDvvneeevvklveefladgaed...........lsevakllveaakeagssDnitvvvv
PPM_PTC7_SpoIIE 113-382 2.8e-29 95.6 In-house 7-229 (230) alignment 
Range on Protein: 113-382
Range on HMM: 7-229/230.0
ERKGEREEMQDAHVILNDITEEcrppsSLITRVSYFAVFDGHGGIRasKFAAQNLHqNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEflkqassqkpA
. .| |..| |||.....   .     |    . .....|||||    ..|.  |. ...|.. . .   .|. ..|  |  ......|           
aaqgarksmedahispanseks.....sggrlalvvgdvdGhGgra..alamgllr.talrelafaglekpeeilrrlnlalaadlede..........p

WKDGSTATCVLAVDNI--LYIANLGDSRAILCRYNEEsqkhaalslskehnptqyeERMRIqKAGGNVR----DGRVLGVLEVSRSIGDGQYKR-CGVTS
.. |.||...|   .   ||.||.|||...|.| ..                    || || .||| ..    .||| |||.||...||  ..   ||..
sssgaTavvalidpstgklyvanaGdsppllvrddgg...................ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvve

-VPDiRRCQLTPN-DRFILLACDGLFKVFTPEEAVNFILSCLEDEkiqtregksaadaryeaACNRLANKAVQRGSADN
  ||     .... |.|. ||.|||. | .|.|.| .....||.                  |...|.  ..  .....
aepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.................aaeglleDDitllvvrv
subfamily_PPM1G2_pd Subfamily PPM1G2 114-388 1.1e-52 171.8 In-house 26-284 (287) alignment 
Range on Protein: 114-388
Range on HMM: 26-284/287.0
RKGEREEMQDAHVILNDITEECRPPsslitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRkfpkGDV-IsvEKTVKRCLLDTFKHTDEEFLKQASSQKpa
 .| | .| |||.. |.. |.   .     ....||||||||| ...|.|...|.. . .     .     | .....| |.|..||||.||. . ..  
mqGyrlnmeDahilenelleksddk.....slalfavfDGhGGakvakyagkklikkiak....kksfk..egaleqilkdafletDeellkdeklkd..

WKDGSTATCVLAVDNILYIANLGDSRAILCRYNEesqkhaALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCG--------VT
 . ||||. ||  .. ||.|| |||||.|.   .      . .|| .| |.. .|. ||..||| |  .|| |.| .||..|| ..|..         ||
esaGstavvvlikeeklyvanaGDsravlsskgn......vkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivt

SVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKiqtregksaadaRYEAACNRLANKAVQRGS------ADNVTVMVV
 |||.   .|...| |..|||||.. |.| .| |... . | ...            . .. ...| .|.... |      .||.||..|
avPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsga............kldeiieelldkclapdssntgvGcDnmtvviv
subfamily_PPM1L_pd Subfamily PPM1L 115-390 6.3e-40 130.1 In-house 13-266 (269) alignment 
Range on Protein: 115-390
Range on HMM: 13-266/269.0
KGEREEMQDAHVILNDITEEcrppssliTRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVIS---VEKTVKRCLLDTFKHTDEEFLKQASSQKP
.| |..|.|   | .||...        |  |.|||||||||  |..|| . | ... .|. . |      .  . .. | |     ||..|..| ... 
lGrrprmedrfeieediknk........tgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraed

awKDGSTATCVLAVDNILYIANLGDSRAILCryneeSQKHAALSLSKEHNPTQYEERMRIQKAGGNVR---DGRVLGVLEVSRSIGDGQYKRCG-VTSVP
    |.||   |  .. | .||.|||| .|.      ..  |. || .| | | .|| ||.|||| .      || ||| .||..||   |    | . |
..iaGttalialvqesdlivanvGdsrGvly.....dkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadp

DIRRCQLTP-NDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTregKSaadaryeaacnrLANKAVQRGSADNVTVMVVRI
||   .|   . .|..||.|||.  |. ||||.||.  |.. .. .   ||            |. .. .||| ||.||.||..
diltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGa...ks............lvlesfkrGsvdnitvlvvkl
subfamily_KAPP-like_pd Subfamily KAPP-like 120-389 5.7e-27 87.4 In-house 11-265 (266) alignment 
Range on Protein: 120-389
Range on HMM: 11-265/266.0
EMQDAHVILNDITEECRppSSLITRVSYFAVFDGHGGIRASKfAAQNLHQNLIRKFPKG----DVISVEKTVKRCLLDTFKHTDEEFLKQAssqkpawKD
||.| ..    ...|     | ..... ||||||| |  |.. ||..| .. . |  |     |        .. |...||. |... .          .
emedvslaiypllkekk..lsncsnialfavfdGhaGkGaad.aakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfe.......ye

GSTATCVLA----VDNILYIANLGDSRAILCRYNEesqkhaALSLSKEHNPTQYEERMRIQKAGGNVRDG--RVLGVlEVSRSIGDGQYK--RCGVTSVP
|.||| .|         | .||.||| |.|.| ||      .| |||.|. .. ||. ||.. |  . |.  |. |.  |||..||   |   .|..| |
GatatlalvwsdGqqrylqvanvGdssaflsrGne......slelskdhkakdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisep

DIR-RCQLTPNDRFILLACDGLFKVFTPEEAVNFIlSCLEDEKiQTREgkSAADARYEAACNRLANKavqrgsaDNVTVMVVR
 .  |  ||| |.|...| |||. | . ..|.. . ..| |.. .| .  . |..  |.| .    |       |||.|.||.
yvsnrilltpfdkflivasdGlwdvisGkdaiekv.kslydqq.ated..kmasslletaiqsikak.......dnvsvivvk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 120-389 2.4e-25 81.9 In-house 10-275 (276) alignment 
Range on Protein: 120-389
Range on HMM: 10-275/276.0
EMQDAHVILNDITEECRppSSLITRVSYFAVFDGHGGiRASKFAAQNLHQNLIRKFPKGDVISVEK---------TVKRCLLDTFKHTDEEFLKQA----
||.| ..    ...|     | ..... ||||||| | . .  ||..|  . . |. |    |. |           .. ||| ||. |... .      
emedvslaiyplldekd..lsncsnialfavfdGhaG.kGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGa

-SSQKPAWKDGSTATCvlAVDNILYIANLGDSRAILCRYNEesqkhaALSLSKEHNPTQYEERMRIQKAGGNVRDG--RVLGVlEVSRSIGDGQYK--RC
 ..    |.||         .  | .||.||| |.|.| ||      .| |||.|. |. ||. ||.. |  . |.  |. |.  |||..||   |   .
tatlalvwsdGeeqqq..qqqrylqvanvGdssaflsrGne......slelskdhkatdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelni

GVTSVPDIR-RCQLTPNDRFILLACDGLFKVFTPEEAVNFIlSCLEDEKiQTREgkSAADARYEAACNRLANKavqrgsaDNVTVMVVR
|..| | .  |  ||| |.|...| |||. | . ..|.. . ..| |.. .| .  . |..  |.| .    |       |||.|.||.
GlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekv.kslydqq.ated..kmasslletaiqsikak.......dnvsvivvk
subfamily_PP2D1_pd Subfamily PP2D1 120-201 3e-06 19.2 In-house 16-88 (492) alignment 
Range on Protein: 120-201
Range on HMM: 16-88/492.0
EMQDAHVILNDITEEcrppssliTRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDViSVEKTVKRCLLDTFKHTDEE
.|.|.... .. ...        . ...|...||. |  | . ||..||. | ..  | |  .|. |..  |.|  . || |
kmeDkrtlqdyfgnd........vnscFfgiyDGynGataAeiaakelhevlleelekvde.rvslttavnlidnndltdye
subfamily_PPM1K_pd Subfamily PPM1K 142-391 9.2e-39 126.1 In-house 28-259 (263) alignment 
Range on Protein: 142-391
Range on HMM: 28-259/263.0
ITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKgdvisvEKTVKRCLLDTFKHTDEEFLKQA---SSQKPAWKDGSTATCVLAVDNI-LYIANLGDS
   . |.||||||.|  | .|. ..|.. | | ..|      || ..  | ..|.. |... . .    ...   . |.||| .|  | . | .|.||||
dpellyvavfdGhaGsaaadfvhdklekilkrllek......ekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGds

RAILCRYNEesqkhaALSLSKEHNPTQYEERMRIQKAGGNVR-----DGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQL-TPNDRFILLACDGLFKV
||||||  .      |  |...|.| . ||. ||..|||.|        .| |.| ..||.|| . || || . |. .. ..   .| |..|  ||.  |
railcrnGk......akkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfv

FTPEEAVNFILSCLEDEKiqtregksaadaryeaACNRLANKAVQRGSADNVTVMVVRIG
 . .|  ...  | . |.                | . |...|.| || ||.|..|| .|
vnsqelcdlvrlchdpee................aahalteqalqygsednatavvvplg
subfamily_PPM1H_pd Subfamily PPM1H 143-175 2.4e-06 19.5 In-house 60-92 (404) alignment 
Range on Protein: 143-175
Range on HMM: 60-92/404.0
TRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKF
  . ||..||||.|  |.  |...||. | .|.
lplayfglfDGhaGsgaalvaskllhkhlkekl
Subfamily Dicty-PPM1L-like 145-389 2.6e-19 62.2 In-house 37-302 (305) alignment 
Range on Protein: 145-389
Range on HMM: 37-302/305.0
VSYFAVFDGHGGIRASKFAAQNLhQNLIRKFPKGDVI-------SVEKTVKRCLLDTFKHTDEEFLKQASSQKP---AWKDGSTATCVLAVDNILyIANL
 |.| |||||.| .|.... ..|  ... |. | . .        |..    .. ...  ||. .|. |.|.     .  .||.|. .|  ....  .. 
lslfGvfdGhnGdiaaeyvkkkl.veivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnkkaGttlngssasvilererti.vsta

GDSRAILCRYNEESQKHAALSLS---------------KEHNPTQYEERMRIQKAGGNVRDGRVL---GVLEVSRSIGDGQYKrCGVTSVPDIRRCQL-T
.|. . |.     .    . |                  ..|  . |.|.||. ... . .   |   ..|..|||.||.. | . |   .|     .  
sdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellvnrllkksrskGdknlk.elviPnndspllvvak

PNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTRegksaADARYEAACNRLANKAVQRGSADNVTVMVVR
.|| |..|| ||| .|.  .. |....  |.|...| .      .  ..   .. ...||.||| ||.|.... 
anDqflvlatdGlwevlsyqdvveevkellrdkssqkk.....iewdfneisrviveeavkrgsgDnitlviik
PP2C_2 Protein phosphatase 2C 145-338 1.1e-08 27.6 Pfam-A 24-187 (212) alignment 
Range on Protein: 145-338
Range on HMM: 24-187/212.0
VSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEK----TVKRCLLDTFKHTDeEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAI
....|| ||.|  . |. .|. . ..... . |    . |.    ...... .  ....  . .....|... . ..| ..... .. ......||....
gwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk.lkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaiv

LCRYNEESQKhAALSLSKEHNPTQYEERMRiqKAGGNVrdgrvlgvlevsrsigdgqykrcgvtsvpDIRRCQLTPNdRFILLACDGLFKVFTPEEAV
. . . | |  .  . |.|.  . .  ...  .|....                             .|||..| |. . .||  ||. . ...||..
vrdrdgevql.lgepdsgeyanettfltse..daeeel.............................rirrlklepg.dalllmTDGvsdslrkeepf
PP2C_2 Protein phosphatase 2C 145-338 1.1e-08 27.6 In-house 24-187 (212) alignment 
Range on Protein: 145-338
Range on HMM: 24-187/212.0
VSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEK----TVKRCLLDTFKHTDeEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAI
....|| ||.|  . |. .|. . ..... . |    . |.    ...... .  ....  . .....|... . ..| ..... .. ......||....
gwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk.lkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaiv

LCRYNEESQKhAALSLSKEHNPTQYEERMRiqKAGGNVrdgrvlgvlevsrsigdgqykrcgvtsvpDIRRCQLTPNdRFILLACDGLFKVFTPEEAV
. . . | |  .  . |.|.  . .  ...  .|....                             .|||..| |. . .||  ||. . ...||..
vrdrdgevql.lgepdsgeyanettfltse..daeeel.............................rirrlklepg.dalllmTDGvsdslrkeepf
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 148-307 5.8e-22 71.6 In-house 24-194 (292) alignment 
Range on Protein: 148-307
Range on HMM: 24-194/292.0
FAVFDGHG--GIRASKFAAQNLHQNLIRKFPKGDVISvEKTVKRCLlDTFKHTDEEFLKQASsqkpawKDGSTATCVLAVDN-ILYIANLGDSRAILCRY
 ||.||||  | . ...|...| ..|.  ...   .| |  ..| | |.  . |. ....        . .....|    |.  |..||.|||||.| | 
aavldGhGvnGdkvaqlaedtlevelleltrqlqels.ealllril.diaakldkltidare......sattavvcarvrddralilanvGdsrallgrc

NEESQKhAALSLSKEHNPTQYEERMRIQKAGGNVRDGRV-----------------LGVLEVSRSIGDGQYKRCGVTSVP
   |..     ||..| |   .|| ||..||| |   ||                  | | .||..||   .  || . |
lggsdy.eliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaeP
PP2C_SIG_SM00331 148-389 4e-16 52.2 In-house 33-216 (217) alignment 
Range on Protein: 148-389
Range on HMM: 33-216/217.0
FAVFDGHG-GIRASKFAAQNLhqNLIRKFPKGDvISVEKTVKRCLLDTFKHtdeeflkqassqkpAWKDGSTATCVLAV----DNILYIANLGDSRAILC
..|.||.| |..|. ...| .  ...|.. . . .......||.     .               .  .|. ||..||.    .. |..||.|||| .| 
lvvaDgmGkGlaAaaassqlr..talrellseg.eelsqalkrlnraiyee..............keekgmfaTlllalydfssgklsyanaGdsrpyll

RYNEESQKHAAlslskehnptqyeermriqkaggnvRDGRVLGVLEVSRsigdgqykrcgvtsvPDIRRCQLTPNDRfILLACDGLFKVFTPEE-----A
| ... ... .                           |..||. . ..               .|||  .| . |. .||. |||. . ....      
rdgklveilkd.........................vegaplGlepevs...............vdirelelekgdl.lllytDGltearsekgfaeerl

VNFILSCLedekiqtregKSAADARYEAACNRLANKAVQRGSADNVTVMVVR
 ... ...          .|.|..  ..  ..| ..| ...  |..||.||.
eeiledlv..........dseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_TAB1_pd Subfamily TAB1 148-205 2e-07 23.1 In-house 30-85 (333) alignment 
Range on Protein: 148-205
Range on HMM: 30-85/333.0
FAVFDGHGGIRASKFAAQNLHQNLIRKfpkgDVIS--VEKTVKRCLLDTFKHTDEEFLKQ
.|||||. | .|.||..|.| ..|. .    .. .   |  ||. |.  |......||..
yavFdGydGnkaakfveqrLvaellle....qltdelaeaevkevlkrafeeverkfles
subfamily_PPM1H_pd Subfamily PPM1H 179-273 6.9e-13 41.1 In-house 128-212 (404) alignment 
Range on Protein: 179-273
Range on HMM: 128-212/404.0
DVISVEKTVKRCLLDTFKHTDEEFLKQASSQKpaWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEEsqkhaaLSLSKEHNPTQyeERMRIQK
  || |. |.  | . |.. ||   .. .. .   | | ||  .| ... ||.|| |||||||.| .|         ||... |    || |.|.
keiskeeLviGalesaflemDeqiarereayr..ikGGCtalvalvllgklYvanaGDsRailvrkdei......iplsadftPet..eRqRlqe
subfamily_PDP_pd Subfamily PDP 186-299 1.3e-16 53.7 In-house 114-241 (398) alignment 
Range on Protein: 186-299
Range on HMM: 114-241/398.0
TVKRCLLDTFKHTDEEFLKQAS--SQKPAWK-------DGSTATCVLAVDNILYIANLGDSRAILCRYNEESQkHAALSLSKEHNPTQYEERMRIQKAG-
.||. |  .|.. |... ..|   ...   .        |..|...|  .. |..|| ||.||.|.. .||..   | .|||... .  ||  ||.|.  
kvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegs.weavkLskdqtadneeEveRikkeHP

--GN---VRDGRVLGVLEVSRSIGDGQYK
   .   .|.||.|| |  .|  || .||
geesktvirngRlLgeLqPlRAFGdvryK
subfamily_PP2D1_pd Subfamily PP2D1 204-355 1.4e-21 69.8 In-house 165-316 (492) alignment 
Range on Protein: 204-355
Range on HMM: 165-316/492.0
KQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEERMRIQKAGG----NVRDGRVLGVLEVSRS---IGDG
..  |..   |. ..    | .  .||||| |. .|.|||      .  |  | .||.|   .|| |..|||.    . . |.| |.|.. |    .||.
ekkdseeGlekesngsevhleelgvlyianaGnvqAvLcr......eGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdp

QYKRCgVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREG
. |.  |   | ..  .|. .. |..||  ||..|.. || .. . . |.  | ..|..
kLkks.vipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvrae
subfamily_PPM1G_pd Subfamily PPM1G 209-389 1.6e-37 122.6 In-house 290-469 (473) alignment 
Range on Protein: 209-389
Range on HMM: 290-469/473.0
QKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYneesqkHAALSLSKEHNPTQYEERMRIQKAGGNVR-DGRVLGVLEVSRSIGDGQYKRC------
..|  . |.||. .|  .. |..|| ||||..|.|         || || .| |   .|. ||.||||.|  |||| | | .|| .||  ||.       
eepGedsGttAvvaLlkekklivAnaGDsRcvlsrn......GkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplk

--GVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQtregkSAADARYEAACNRLANKAVQRGS-ADNVTVMVVR
   .. .|||.  .||..| |. |||||.. | . .| |.|. . |.... .     . ...  |   . ||.     |.  || ||..| 
eqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees.....vlseiveeLlDaclapdtsgDGtGCDnmtviivl
subfamily_TAB1_pd Subfamily TAB1 213-300 8.2e-15 47.4 In-house 127-214 (333) alignment 
Range on Protein: 213-300
Range on HMM: 127-214/333.0
WKDGSTATCVLAVDNILYIANLGDSRAILCRYNEeSQKHAAlsLSKEHNPTQYEERMRIQKAGG---NVRDGRVLGVLEVSRSIGDGQYKR
 ..|.||  .| . | ||.|| |||||.|.. .| |.|.    ||..|.    .| .|... |    ...  ..||  |  ||||| . | 
isgGttAvvalifnnkLyVaNvGdsrAllvkrke.sekvkq..LsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkk
subfamily_PHLPP_pd Subfamily PHLPP 228-341 7.6e-09 27.8 In-house 106-212 (246) alignment 
Range on Protein: 228-341
Range on HMM: 106-212/246.0
ILYIANLGDSRAILCRyneeSQKhaALSLSKEHNpTQYEERMRIQKAGGNV-RDGRVLGVLEVSRSIGDgQYKRCGVTSVPDIRRCQLTPNDRFILLACD
 | .|. |   |.|.|     .|   | |||..   . .|  ||..| . .  |... ||.| .| .|   .    |   | .|  .||..| ....  .
sLevAsvGtlqavliR....ngk..klrlsksyv.iekdelkrikeakaiitednkingviestrllGy.tflfPvvlPkphvrevlLteqdellivGnk

GLFKVFTPEEAVNFI
 |..|.  .|||. .
alWevlsideaveav
subfamily_PPM1H_pd Subfamily PPM1H 276-389 1.3e-06 20.5 In-house 270-401 (404) alignment 
Range on Protein: 276-389
Range on HMM: 270-401/404.0
GNVRDGRVLGVLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTP----NDRFILLACDGLFKVFTPEEAVNFILSCLEDEK-IQTREGKSAA---
|. .  |.|. . |.| .|| . | .         ...||..|  .||     .|  ..|| |||. | . ||. . . . |.. .  ...   ..|   
gegkkaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkrytavaqeL

--DARYEAACNRLANKAVQRGSADNVTVMVVR
   || . . .    |  . .| |...|.|. 
vaaarGklkdkgWrlkeekaasvDDisvfviP
subfamily_PPM1D_pd Subfamily PPM1D 287-390 1.4e-12 40.4 In-house 201-307 (309) alignment 
Range on Protein: 287-390
Range on HMM: 201-307/309.0
LEVSRSIGD-----GQYKRCGVTSVPDIRRCQLTPNDR-FILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQrgsA
| |.||.||      . ..  |  .||.   .|.||.. ||.|| |||..| |||.||... .  | ....  ...| | |  . | .| ..| ..   |
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklr...a

DNVTVMVVRI
|||.|.|| .
Dnvsvivvil
subfamily_PDP_pd Subfamily PDP 303-381 3e-10 32.8 In-house 270-348 (398) alignment 
Range on Protein: 303-381
Range on HMM: 270-348/398.0
VTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSAD
.|. |..   .|..||.|..|| |||. ....||.|. .   |...| ..  . . |..  .   ..|.... .  ..|
ltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkqvveelkerkrklkred
PPM_PTC7_SpoIIE_motif 310-390 8.4e-07 22.6 In-house 5-80 (81) alignment 
Range on Protein: 310-390
Range on HMM: 5-80/81.0
RRCQLTPNDRfILLACDGLF-------KVFTPEEAVNFILSCledekiqtrEGKSaadarYEAACNRLANKAVQRG---SADNVTVMVVRI
...|| | |. .||..|||.       ..|..||.. .. ..         ||||      . .. .| ......|   ..|..|..|.|.
aefqLkpgdv.llLyTDGltEardsdgelfgkeellrladra.........egks.....lqeladklvdevlengsgereDDitllvlrv
PPM_PTC7_motif 322-383 2.3e-12 40.2 In-house 1-51 (51) alignment 
Range on Protein: 322-383
Range on HMM: 1-51/51.0
LLACDGLFKVFTPEEAVNFILSCLEDEKIqtregksaadaRYEAACNRLANKAVQRGSADNV
.||.|||. |....|||... ..|....            ... |...|...|..|||.||.
iLAsDGLWDvlsdqeavdlvrdqlskkgl...........spqeaAeklvdealargseDni