Gene PHLPP1 in Homo sapiens

Synonym: PHLPP, PLEKHE1, SCOP, PHLPP1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PHLPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP171_AA protein Get Run
HsapP171_AA_1169-1422 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
LRR_8 Leucine rich repeat 639-703 6.6e-07 18.6 Pfam-A 3-61 (61) alignment 
Range on Protein: 639-703
Range on HMM: 3-61/61.0
ISSVDLSCCSLEHLPANLFYSQD-LTHLNLKQNFL-RQNPSLpaarglneLQRFTKLKSLNLSNNHL
....|||...|...| . | . . |..|.|. | | . .| .        .. ...|..||||.|.|
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispea........fkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 684-707 1.3e-06 17.8 Pfam-A 16-40 (44) alignment 
Range on Protein: 684-707
Range on HMM: 16-40/44.0
LNE-LQRFTKLKSLNLSNNHLGDFP
|.. | ....||.||||||.. |..
lppelanLpnLktLnLsnNpisdls
LRR_4 Leucine Rich repeats (2 copies) 691-730 2.7e-06 16.8 Pfam-A 1-40 (44) alignment 
Range on Protein: 691-730
Range on HMM: 1-40/44.0
TKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVP
|.|..|.|||| . | |  . . | | .||.| | . ...
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls
LRR_8 Leucine rich repeat 714-771 1.4e-10 30.4 Pfam-A 1-60 (61) alignment 
Range on Protein: 714-771
Range on HMM: 1-60/61.0
PTLAELNVSCNALRSVPA-AVGVMHNLQTFLLDGNFLQSLPAEL-ENMKQLSYLGLSFNE
| | ||..|.| |...|  . . ..||... | || |.|...|. .....|..| || |.
pnLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNr
LRR_4 Leucine Rich repeats (2 copies) 738-777 5.4e-10 28.6 Pfam-A 2-41 (44) alignment 
Range on Protein: 738-777
Range on HMM: 2-41/44.0
NLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPE
||..  | .| ...||.|| |...| .| || | ..|...
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa
LRR_8 Leucine rich repeat 761-817 5.2e-09 25.4 Pfam-A 2-59 (61) alignment 
Range on Protein: 761-817
Range on HMM: 2-59/61.0
QLSYLGLSFNEFTDIP-EVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLN
.|..| ||.|....|| .....|..  .|  |||. ...  .|. ..|......|. |
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgN
LRR_8 Leucine rich repeat 896-952 7.3e-09 24.9 Pfam-A 3-61 (61) alignment 
Range on Protein: 896-952
Range on HMM: 3-61/61.0
LSYMDVSRNRLENVPEWVCE-SRKLEVLDIGHNQICELPARLFCNS-SLRKLLAGHNQL
|.. |.|.|||...|. . .   .|.|||...| . ......| .  |||.|   .|.|
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 899-934 1.4e-07 20.9 Pfam-A 6-41 (44) alignment 
Range on Protein: 899-934
Range on HMM: 6-41/44.0
MDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPA
 | |.|.....|...   ..|..|.. .|.|..|.|
LdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa
LRR_4 Leucine Rich repeats (2 copies) 918-956 6.9e-07 18.7 Pfam-A 2-40 (44) alignment 
Range on Protein: 918-956
Range on HMM: 2-40/44.0
KLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLP
.|||||. .|.| .||. |   ..|. |   .|..  |.
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls
LRR_4 Leucine Rich repeats (2 copies) 962-1003 2e-06 17.3 Pfam-A 1-41 (44) alignment 
Range on Protein: 962-1003
Range on HMM: 1-41/44.0
TSVEVLDVQHNQLLELPPNlLMKADSLRFLNASANKLESLPP
|. |||| ..|.. .|||  | .  .|. || | |....|..
tnLevLdLsnNnIkdlppe.lanLpnLktLnLsnNpisdlsa
LRR_8 Leucine rich repeat 963-1024 7.4e-07 18.5 Pfam-A 2-61 (61) alignment 
Range on Protein: 963-1024
Range on HMM: 2-61/61.0
SVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNsiLQELYLTNNSL
....||...|.| ..|.. . . ..|. |. | |.|.|..| ...  ..  |.||.| .|.|
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLps..LreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 987-1026 7.7e-07 18.6 Pfam-A 2-38 (44) alignment 
Range on Protein: 987-1026
Range on HMM: 2-38/44.0
SLRFLNASANKLESLPPaTLSEETNsiLQELYLTNNSLTD
.|..|. | |....||| .|.  .|  |..|.|.|| ..|
nLevLdLsnNnIkdlpp.elanLpn..LktLnLsnNpisd
LRR_8 Leucine rich repeat 1014-1072 2.1e-10 29.8 Pfam-A 3-61 (61) alignment 
Range on Protein: 1014-1072
Range on HMM: 3-61/61.0
LQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKL
|.||.|.||.|.. .   . | ..|| |   .|.|.| ..  ...|. |.|..||||.|
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 1014-1053 1.7e-07 20.6 Pfam-A 3-41 (44) alignment 
Range on Protein: 1014-1053
Range on HMM: 3-41/44.0
LQELYLTNNSLTDkcVPL-LTGHPHLKILHMAYNRLQSFPA
|..|.|.||...|  .|  | . | || |....|......|
LevLdLsnNnIkd..lppelanLpnLktLnLsnNpisdlsa
LRR_8 Leucine rich repeat 1036-1085 1.7e-09 27.0 Pfam-A 1-51 (61) alignment 
Range on Protein: 1036-1085
Range on HMM: 1-51/61.0
PHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTI-MNCRRM
|.|| |.   |||.. | .   .|. |...|||||.|| |.. .  .... 
pnLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsL
LRR_4 Leucine Rich repeats (2 copies) 1036-1076 9.9e-08 21.4 Pfam-A 1-40 (44) alignment 
Range on Protein: 1036-1076
Range on HMM: 1-40/44.0
PHLKILHMAYNRLQSFPASkMAKLEELEEIDLSGNKLKAIP
. |. |  ..|.... |..  |.|  |....||.|..  ..
tnLevLdLsnNnIkdlppe.lanLpnLktLnLsnNpisdls
PP2Cc_SM00332 1170-1420 2.3e-43 141.5 In-house 6-274 (274) alignment 
Range on Protein: 1170-1420
Range on HMM: 6-274/274.0
APAVWSHGYTEASGVKNKLCVAALSVNNF-CDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKN-----EEEYMVNTFIVMQRKLGTAGQ----
  . .|.|...  | ...   |  .|...   .. ...|||||    ||. ...  . ..|.|||.| |.      ||.. . |  .. .. .. |    
snlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskel

---KLGGAAVLCHIKHDPvdpggsftLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDgKVNGVTESTRILGYTFLH-------P
   . |  ||....| .         |  |||| .. ||||||| ..||.    . |.|.||||. .. .  . .|||. ...| .|  ||        |
enalsGstavvallkked........lyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg.rvngglavsrafGdhflkknkklkep

SVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVP------DALAAAKKLCTLAQSY-GCHDSISAVVV
 ... |.|. | ||..|||.|| | ||||.|| .|.|. ||.        |. .||..|. .|... |..| |..|||
yitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_PHLPP_pd Subfamily PHLPP 1171-1423 1.9e-122 399.8 In-house 2-246 (246) alignment 
Range on Protein: 1171-1423
Range on HMM: 2-246/246.0
PAVWSHGYTEASGVKNKLCVAALsvnnfcdNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHI
.||.|.|..|..|||||||||||       ..|||||.||||||.|...|||..|.|.|.||.||.|||||||.||..|.|||||.||.|||.||.|..|
lavfsiGlsesaGvknklcvaal.......svealyGlfdGdrneelssllqrlmkdvlkeevqkdkneeeymkntllvaqrklGeaGeklgsaallili

KHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEeELKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFI
.||.|||..||.|..|.||..|.||.||||.|.||.||..... ||||||..|||||||.|.|||.||||.||||||.|.|.|.|||..||||.|||..|
rhdkvdPaksfsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytflfPvvlPkphvrevlLteqdelli

LGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLS
.|.| ||..||..|||||||...|.|.|||||..||||||..||.|..||.|.
vGnkalWevlsideaveavrkeedplvaAkklvdlaqsygaadsvsvlvvrlr
0034914 PP2C-like 1172-1422 6e-46 149.6 In-house 19-290 (295) alignment 
Range on Protein: 1172-1422
Range on HMM: 19-290/295.0
AVWSHGYTEASGVKNKLCVAALSVNNFC--DNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKT--------KNEEEYMVNTFIVMQRKLGTAGQK-
 ....|.    | ...   | | | |..  ..  .|.|||||  . ..  ... .. ..|.|.|.|.         . ||.....|. ....| . ... 
lllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr

-----LGGAAVLCHIKHDpvdpggsfTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEdGKVNGVTESTRILGYTFLH-------
      |  ||...|...        .|. |||| .. ||.|||....|..   .. |.| .||...  ...  | ||||   || ||. .|.       
pelagsGtTavvalirgn........klyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlklllslll

--PSVVPRPHVQSVLLT-PQDEFFILGSKGLWDSLSVEEAVEAVRN----VPDALAAAKKLCTLAQSYGCHDSISAVVVQL
  | |.. |.|... || ..|.|..|.| |||| || ||.|. ||.      |. .||..|. || ..|..| |..|||.|
leplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrl
PP2C Protein phosphatase 2C 1177-1415 1.1e-34 113.2 Pfam-A 4-255 (255) alignment 
Range on Protein: 1177-1415
Range on HMM: 4-255/255.0
GYTEASGVKNKLCVAALSVNNFC----DNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKN--EEEYMVNTFIV-MQRKLGT-----AGQKLGGA
| .|..|.. ..  | .. .|..    ....|...||||    |.  . . .. .||.|  ....   .|. . ..|   .. .| .     . .| |  
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGst

AVLCHIKHDPvdpggsftLTSANVGKCQTVLCRNGKPL-PLSRSYIMSCEEELKRIKQHKAIITEDGKVNGVTESTRILGYTFLHP----SVVPRPHVQS
||.. |...         |  |||| ...||||....   |..    |.|.| .||..    . . |.|||. . .| ||...| |     |.. |.|.|
avvalirgkk........lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvts

VLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPD----ALAAAKKLCTLAQSYGCHDSI
| ||..|||.||.| |||| || .|||. ||.  .    .  ||..|.. |...|..|.|
vklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 1177-1415 1.1e-34 113.2 In-house 4-255 (255) alignment 
Range on Protein: 1177-1415
Range on HMM: 4-255/255.0
GYTEASGVKNKLCVAALSVNNFC----DNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKN--EEEYMVNTFIV-MQRKLGT-----AGQKLGGA
| .|..|.. ..  | .. .|..    ....|...||||    |.  . . .. .||.|  ....   .|. . ..|   .. .| .     . .| |  
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGst

AVLCHIKHDPvdpggsftLTSANVGKCQTVLCRNGKPL-PLSRSYIMSCEEELKRIKQHKAIITEDGKVNGVTESTRILGYTFLHP----SVVPRPHVQS
||.. |...         |  |||| ...||||....   |..    |.|.| .||..    . . |.|||. . .| ||...| |     |.. |.|.|
avvalirgkk........lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvts

VLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPD----ALAAAKKLCTLAQSYGCHDSI
| ||..|||.||.| |||| || .|||. ||.  .    .  ||..|.. |...|..|.|
vklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 1180-1415 3.9e-32 104.7 In-house 7-259 (259) alignment 
Range on Protein: 1180-1415
Range on HMM: 7-259/259.0
EASGVKNKLCVAALSVNNFC----DNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKN--EEEYMVNTFIV--MQRKLGT-----AGQKLGGAAV
...|.. ..  | .. .|..    .. .|...||||    |.  . . .. .||.|. ....    |. . ..|    .  .| .     . .. |  ||
afqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsGstAv

LCHIKHDPvdpggsftLTSANVGKCQTVLCRNGKPL-PLSRSYIMSCEEELKRIKQHKAIIT--EDGKVNGVTESTRILGYTFLHP------SVVPRPHV
.. | ..         |  |||| ...||||.|..  .|....  |.|.| .||..    .   ..|.|||| . .| .|...| |       |.. |..
valitgsk........lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdi

QSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPD---ALAAAKKLCTLAQSYGCHDSI
.|. ....|||.||.| |||| .| .|||. ||.. .   .  ||.||.. |...|..|.|
sstkideedefliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 1197-1423 9e-27 86.9 In-house 29-254 (255) alignment 
Range on Protein: 1197-1423
Range on HMM: 29-254/255.0
NFCDN-REALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKN-EEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHDpvdpggsfTLTSANVGKCQTV
.| |.  | .| .|||    .       ..  |||| |.  .   .... ...  .. ...  .. .| .|.   | .|            ||||  . |
sfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserpkfiGttaasvliied........kvyianvGdsrvv

LC-RNGKPLPLSRSYIMSCEEELKRIKQHKAIITED---GKVNGVTESTRILGYTFLHPSVVPRPHVQ-SVLLTPQDEFFILGSKGLWDSLSVEEAVEAV
|| ..|    ||  .  | |.| |||..    . ..    .|||    .| || .||.| ||| |... |.  . .|.|.||   |.|| .| ||||| |
lcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiv

RNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLS
 .. |.  ||.||  || | |  | || .|..||
agisdpekaaeklrdlayssGstdnisvivikls
subfamily_PPM1G2_pd Subfamily PPM1G2 1200-1394 2.5e-12 39.3 In-house 49-248 (287) alignment 
Range on Protein: 1200-1394
Range on HMM: 49-248/287.0
DNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQK-TKNEEEYMVNTFIVMQRKLGTA----GQKLGGAAVLCHIKHDPvdpggsftLTSANVGKCQTV
|.. ||..||||    .|       .  ..|.  .    . |. . ..|. . ..|        .. |  ||   ||..         |  ||.|  ..|
dkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkdesaGstavvvlikeek........lyvanaGDsrav

LCRNGKPLPLSRSYIMSCEEELKRIKQHKAIItEDGKVNGVTESTRILG-YTFLHPS--------VVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEA
|. .|.   ||. .  . |.| |||..   .. | ..|||.    | || ..| . .        |   | |    |...||| .|   |.|| |. .| 
lsskgnvkalsfDhkPqeesekkriiaagGfv.elnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkev

VEAVRNVPD
|. ||.   
vdlvrerlv
subfamily_PPM1E_pd Subfamily PPM1E 1201-1422 6.7e-23 74.2 In-house 38-262 (265) alignment 
Range on Protein: 1201-1422
Range on HMM: 38-262/265.0
NREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTA----GQKLGGAAVLCHIKHDPvdpggsftLTSANVGKCQTVLC
. .| ..||||   ||  .  .  .   |... . ... .| . ..| .. ... .     . | |  || . |..|         |  | .|  |..|.
keraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklksGstavvvliekdq........lyvaWlGDsqallv

RNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDG--KVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNV--
|.|. . | . .  . |.| |||..   ..   |  .||||   .| .| . |.| |.  . | .| |. ..|. ||.. |||| .  ||.|..|..   
rkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefla

---PDALAAAKKLCTLAQSYGCHDSISAVVVQL
    |   .||.|.. |.. | .| |..||| |
dgaedlsevakllveaakeagssDnitvvvvfl
subfamily_PPM1A_pd Subfamily PPM1A 1202-1422 2.1e-19 63.0 In-house 41-280 (282) alignment 
Range on Protein: 1202-1422
Range on HMM: 41-280/282.0
REALYGVFDGDRNVEVP-YLLQCTMSDILAE-EL-------QKTKNEEEYMVNTFIVMQRK---LGTAGQ---KLGGAAVLCHIKhdpvdpggSFTLTSA
  ... ||||    ||  |  .. .. || | ||       ..... .| . . |. .. .   | |  .   | |  || . ..          .|  |
dwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlktadksGsTavtvlvs........ekhliia

NVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITeDGKVNGVTESTRILGYTFLHP---------SVVPRPHVQSVLLTPQDEFFILGSKGLW
|.| . .|||||||   |..    | ..| |||.|    ..  ..|||    .| ||  ..            |.. |.|.|.  . .|.|..| . |.|
nlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv.vsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiw

DSLSVEEAVEAVRNV----PDALAAAKKLCTLAQSYGCHDSISAVVVQL
| || ||.|| ||.      .. . ||.|   | . | .| .|..|| .
DvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
0049733 PP2C-like 1203-1422 9.7e-30 96.7 In-house 26-233 (235) alignment 
Range on Protein: 1203-1422
Range on HMM: 26-233/235.0
EALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNE--EEYMVNTFIVMQRKLGTAGQK------LGGAAVLCHIKHDpvdpggsfTLTSANVGKCQTV
 .|..|.||  . ..  ..  .. ..|.|.|...  .  ||.....|  ... |   ...       |  ||.. . ..        .|. |||| .  .
lllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTavvalldgg........klyvanvGDsray

LCRNGKPLPLSRSYIMSCEEELKRIKQHKAIItedgKVNGVTESTRILGYTFLHpsvvprPHVQSVLLTPQDeFFILGSKGLWDSLSVEEAVEAVRNvPD
|.|.|| ..|..   .. |.| .||..   ..     |.|.   || || ..|.      |.|... |.|.| |..| | |||| || ||.|. .|.  |
llrdgklvqltedhspvnelerqriitaggav....rvpgrlaltralGdlllk......pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.ld

ALAAAKKLCTLAQSYGCHDSISAVVVQL
. .||..|. || ..| .| |..|||.|
leeaaerlvelalarggrDNiTvvvvrl
subfamily_KAPP-like_pd Subfamily KAPP-like 1203-1422 1.5e-20 66.3 In-house 34-266 (266) alignment 
Range on Protein: 1203-1422
Range on HMM: 34-266/266.0
EALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEE--EYMVNTFIVMQRKLGTAGQKL------GGAAVLCHIKHDPvdpgGSFTLTSANVGKCQTV
 ||..||||     .    .  . ..| . |..||...  . . .   ...  .    .||      | .| |. . .|         | .||||   . 
ialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdG....qqrylqvanvGdssaf

LCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITED-GKVNGVTEStRILGYTFLHP---SVVPRPHVQ-SVLLTPQDEFFILGSKGLWDSLSVEEAVEAV
|.|  . | ||  .    .|| .|||..   ....  ..||.. | | ||  |..     ..  |.|   .||||.|.| |. | |||| .| ..|.| |
lsrGneslelskdhkakdpeekqrikddGitlsdnqtrinGlavs.ralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekv

RNVPDALAAAKKLC-----TLAQSYGCHDSISAVVVQL
. . |  |...|..     |  ||  ..| .| .||.|
kslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_PPM1K_pd Subfamily PPM1K 1207-1423 8.1e-18 57.5 In-house 35-259 (263) alignment 
Range on Protein: 1207-1423
Range on HMM: 35-259/263.0
GVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKL-GGAAVLCHIKHDPVDP-GGSFTLTSANVGKCQTVLCRNGKPLPL
.||||   .         .  || . |.| |. |. ..|.|  ...||    . .   |  |       |        |  |..|  ...||||||.  |
avfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGkakkl

SRSYIMSCEEELKRIKQHKAIITE----DGKVNGVTESTRILGYTFLHPS-VVPRPHVQSVLL-TPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAA
.| .  . ||| .|||.    ..       .|||.   || ||   | .. |.  |. .|. .   .| |..| . |. . .. .|  . ||   |   |
trdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlchdpeea

AKKLCTLAQSYGCHDSISAVVVQLS
|. |.. |  ||..|  .|||| | 
ahalteqalqygsednatavvvplg
subfamily_PPM1G_pd Subfamily PPM1G 1236-1391 1e-16 54.0 In-house 271-427 (473) alignment 
Range on Protein: 1236-1391
Range on HMM: 271-427/473.0
TKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHDpvdpggsfTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDGKVNGV
 ...|.  ... .  . .  . |.. |  || . .|..        .|. ||.| . .||.|||| | ||  .    |.||.||..    ..|||.||| 
eedgegeeakeeldgseekeepGedsGttAvvaLlkek........klivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGG

TESTRILGYTF-LHPS--------VVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRN
    | ||  .  . .        .   | ..  .||..|||..| . |.|.... .| |. ||.
LnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvra
PPM_PTC7_SpoIIE 1239-1411 1e-13 44.7 In-house 69-226 (230) alignment 
Range on Protein: 1239-1411
Range on HMM: 69-226/230.0
EEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHikH--DPvdpggsFTLTSANVGKCQTVLCRN-GKplplsrsyimsceeELKRIKQHKAI-I-TEDGKVN
 || . ...  ....| .. .. |  ||...  .  .        .|. ||.| .  .|.|. |.              | .||. . .. .  ..| |.
peeilrrlnlalaadledepsssgaTavval..idpst......gklyvanaGdsppllvrddgg..............ererivagglpslGilpgrvf

GVTESTRILGYTFLHP---SVVPRPHvQSVLLTPQ-DEFFILGSKGLWDSLSVEEAVEAVRNVPDALaAAKKLCTLAQSYGC
||.. ..  | ..| .    | ..|. .|  .... ||| ||.|.|||| || .|.|..||.  ... ||..| . ......
gvlavslapGdllllytDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.aaeglleDDitllv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 1262-1422 2.6e-18 58.9 In-house 105-276 (276) alignment 
Range on Protein: 1262-1422
Range on HMM: 105-276/276.0
GGAAVLCHIKHDP--VDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITED-GKVNGVTEStRILGYTFLHP---SVVPRP
| .| |. . .|    .      | .||||   . |.|  . | ||  .  .  || .|||..   ....  ..||.. | | ||  |..     ..  |
GatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinGlavs.ralGdhfikelniGlisep

HVQ-SVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLC-----TLAQSYGCHDSISAVVVQL
.|   .||||.|.| |. | |||| .| ..|.| |. . |  |...|..     |  ||  ..| .| .||.|
yvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_PPM1L_pd Subfamily PPM1L 1282-1423 1.3e-15 50.4 In-house 119-267 (269) alignment 
Range on Protein: 1282-1423
Range on HMM: 119-267/269.0
TLTSANVGKCQTVLC-RNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDG--KVNGVTESTRILGYTFLH--PSVVPRPHVQSVLLT-PQDEFFILGSKG
 |. ||||  . ||. ..|| .|||  .     .| ||||.   .|. .|  .|.||   .| ||   |.    |.. | . .  |   . ||.|| | |
dlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdlddhkpeflilasdG

LWDSLSVEEAVEAVRN-VPDALAAAKKLCTLAQSYGCHDSISAVVVQLS
|||..| ||||. ... . .    || |   .   |. | |. .||.|.
lwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvklk
subfamily_ILKAP_pd Subfamily ILKAP 1282-1394 1.7e-14 46.7 In-house 126-244 (293) alignment 
Range on Protein: 1282-1394
Range on HMM: 126-244/293.0
TLTSANVGKCQTVLCRN---GK---PLPLSRSYIMSCEEELKRIKQHKAIITeDGKVNGVTESTRILGY-TFLHPSVVPRPHVQSVLLTPQDEFFILGSK
.| .||.|  ..||.|.   |.    ..|.. .    .|| |||..  . .. ||.|.|| | .| .|   | .  |.  |.|. . ||. | | .|   
vlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr.dgrvlGvlevsrsiGdgrfkrlGvistPdvkkceLtendlfvvlaCd

GLWDSLSVEEAVEAVRNVPD
|||...|..|.|. . .| .
GLwkvfsadevvkfilkvle
subfamily_PP2D1_pd Subfamily PP2D1 1283-1391 4.4e-20 64.8 In-house 190-304 (492) alignment 
Range on Protein: 1283-1391
Range on HMM: 190-304/492.0
LTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITED---GKVNGVTESTRILGY---TFLHPSVVPRPHVQSVLLTPQDEFFILGSKGL
|  ||.|  | ||||.||   | | . .  ..| .|.... .....    |.|||... || ||.   . |. ||.| |...|| |. .. | .| | ||
lyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnGl

WDSLSVEEAVEAVRN
|. || || .. |..
WevlseeevlsLvkq
Subfamily Dicty-PPM1L-like 1313-1427 1.6e-06 20.1 In-house 180-291 (305) alignment 
Range on Protein: 1313-1427
Range on HMM: 180-291/305.0
EEELKRIKQHKAIITEDGKV--NGVTESTRILGYTFLHPSVVPRPHVQ-SVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLctlaqSY
.|.  ||   .| . . |..  |.. .  |  |   |.  |.| .  .  |.  ..|.|..|   |||. || .. || |...       ||.      .
deiririeslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkki.....ew

GCHDsISAVVVQLSVTED
   . || |.|...|  .
dfne.isrviveeavkrg
subfamily_PDP_pd Subfamily PDP 1349-1395 1.1e-08 27.6 In-house 268-314 (398) alignment 
Range on Protein: 1349-1395
Range on HMM: 268-314/398.0
PSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDA
| .  .| |.|  |...| |..|.. ||||.|| ||.|. | .  . 
PYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlak
subfamily_PPM1D_pd Subfamily PPM1D 1351-1392 1.1e-06 20.9 In-house 222-264 (309) alignment 
Range on Protein: 1351-1392
Range on HMM: 222-264/309.0
VVPRPHVQSVLLTPQDE-FFILGSKGLWDSLSVEEAVEAVRNV
| | |.|. . |.|..| | ||.| |||. |. |.||. |.. 
vsPePdvkvrtldpneekfiilasDGlwnvltpedavsvveke
PPM_PTC7_motif 1370-1415 3.6e-09 30.0 In-house 1-51 (51) alignment 
Range on Protein: 1370-1415
Range on HMM: 1-51/51.0
ILGSKGLWDSLSVEEAVEAVRNVPD-----ALAAAKKLCTLAQSYGCHDSI
||.| |||| || .|||. ||   .        ||.||.. |...|..|.|
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni