Gene PHLPP2 in Homo sapiens

Synonym: PHLPPL, PHLPP2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PHLPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP172_AA protein Get Run
HsapP172_AA_778-1034 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
LRR_8 Leucine rich repeat 250-311 3.9e-06 16.2 Pfam-A 2-61 (61) alignment 
Range on Protein: 250-311
Range on HMM: 2-61/61.0
RISTVDLSCYSLEEVPEHLFYSQD-ITYLNLRHNFMQLERPGGldtLYKFSQLKGLNLSHNKL
.....|||. .|...|.. | . .  ..|.|..|  .   |.    . .. .|. ||||.|.|
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispea...fkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 323-361 5.1e-09 25.5 Pfam-A 2-40 (44) alignment 
Range on Protein: 323-361
Range on HMM: 2-40/44.0
TLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLP
 |..|.|| |   ||| ...|| ||.|| |..| .. |.
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls
LRR_8 Leucine rich repeat 323-380 4.7e-08 22.3 Pfam-A 2-61 (61) alignment 
Range on Protein: 323-380
Range on HMM: 2-61/61.0
TLTELNLSCNGFHDLP-SQIGNLLNLQTLCLDGNFLTTLPEEL-GNLQQLSSLGISFNNF
 |.||.||.| . ..| .  ..| ||..| | || |.....|.  .|..|..| .| |..
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 346-384 1.7e-09 27.0 Pfam-A 2-40 (44) alignment 
Range on Protein: 346-384
Range on HMM: 2-40/44.0
NLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIP
||..| | .| .. ||.||.||..| .| .| |..| ..
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls
LRR_8 Leucine rich repeat 369-427 1.9e-07 20.4 Pfam-A 2-61 (61) alignment 
Range on Protein: 369-427
Range on HMM: 2-61/61.0
QLSSLGISFNNFSQIPE-VYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHL
.|..| .|.|... ||. . ..|. |      ||.|.... .... ........|. |.|
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_8 Leucine rich repeat 393-451 1.5e-07 20.7 Pfam-A 3-61 (61) alignment 
Range on Protein: 393-451
Range on HMM: 3-61/61.0
LDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRL
| ..   .| |.|.  |....... |. ||. | ||..  | ..| .......|..|||
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_8 Leucine rich repeat 440-492 1.4e-06 17.6 Pfam-A 2-61 (61) alignment 
Range on Protein: 440-492
Range on HMM: 2-61/61.0
HITHVDLRDNRLTDLD---LSSLCSLEQLHCGRNQLRELT---LSGF-SLRTLYASSNRL
.....||..|||....   ...| .|..|  ..| | ..    ..|. ||| |. |.|||
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 441-475 1.3e-07 21.0 Pfam-A 3-39 (44) alignment 
Range on Protein: 441-475
Range on HMM: 3-39/44.0
ITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLREL
 ...||..|...||.  |..| .|..|.. .|.. .|
LevLdLsnNnIkdlppelanLpnLktLnLsnNpisdl
LRR_8 Leucine rich repeat 503-559 1.8e-08 23.6 Pfam-A 2-60 (61) alignment 
Range on Protein: 503-559
Range on HMM: 2-60/61.0
LLTFLDLSRNLLECVPDWACE-AKKIEVLDVSYNLLTEVPVRILSSL-SLRKLMLGHNH
 |. ||||.| |. .|. . .  .. .||| |.| |.... .....| |||.| | .|.
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNr
LRR_4 Leucine Rich repeats (2 copies) 525-566 1.3e-06 17.9 Pfam-A 1-42 (44) alignment 
Range on Protein: 525-566
Range on HMM: 1-42/44.0
KKIEVLDVSYNLLTEVPVRiLSSL-SLRKLMLGHNHVQNLPTL
.. |||| |.| ....|   |..| .|. | | .|....|..|
tnLevLdLsnNnIkdlppe.lanLpnLktLnLsnNpisdlsaL
LRR_8 Leucine rich repeat 572-632 7.6e-10 28.0 Pfam-A 3-61 (61) alignment 
Range on Protein: 572-632
Range on HMM: 3-61/61.0
LEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACtgEESLSMLQLLYLTNNLL
|..|||..| |...|.. |..  ||..|. | |.|.|... .   ..|  |. |.| .| |
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispea..fkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 572-610 2.4e-07 20.2 Pfam-A 3-40 (44) alignment 
Range on Protein: 572-610
Range on HMM: 3-40/44.0
LEVLDLQHNALTRLPDTLfSKALNLRYLNASANSLESLP
||||||..| .. || .| ..  ||..|| | | ...|.
LevLdLsnNnIkdlppel.anLpnLktLnLsnNpisdls
LRR_8 Leucine rich repeat 645-703 9.1e-13 37.4 Pfam-A 2-61 (61) alignment 
Range on Protein: 645-703
Range on HMM: 2-61/61.0
HLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPT-TIANCKRLHTLVAHSNNI
.|. |.| ||.|.. | . ...|. |..|.||||.||.|.. .......|  |  ..|..
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 646-684 2.2e-09 26.7 Pfam-A 3-40 (44) alignment 
Range on Protein: 646-684
Range on HMM: 3-40/44.0
LRILHLANNQLQTFPASkLNKLEQLEELNLSGNKLKTIP
|. | |.||...  |.. | .| .|..||||.|..  ..
LevLdLsnNnIkdlppe.lanLpnLktLnLsnNpisdls
LRR_4 Leucine Rich repeats (2 copies) 669-706 8.3e-10 28.0 Pfam-A 2-39 (44) alignment 
Range on Protein: 669-706
Range on HMM: 2-39/44.0
QLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIF
.||.|.||.|..| .| ..||.. | ||   .|.|| .
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdl
LRR_4 Leucine Rich repeats (2 copies) 692-728 6e-06 15.7 Pfam-A 2-39 (44) alignment 
Range on Protein: 692-728
Range on HMM: 2-39/44.0
RLHTLVAHSNNISIFPE-ILQLPQIQFVDLSCNDLTEI
 |..|   .|||.  |. . .||. .  .|| | ....
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdl
0034914 PP2C-like 779-1034 5.4e-41 133.4 In-house 16-291 (295) alignment 
Range on Protein: 779-1034
Range on HMM: 16-291/295.0
VTSTFWSHGLAEMAGQRNKLCVSALAMDSFA--EGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQS--------TNDTVFMANTFLVSHRKLGMAG
    ....| | . |.|..   . |.. ..   .. ....|.|||  . .  .... .. . |||....         ..   .. ..||  ...|   .
slllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellela

QK------LGSSALLCYIRPDtadpassfSLTVANVGTCQAVLCRGGKPVPLSKVFSLEqDPEEAQRVKDQKAIITEdNKVNGVTCCTRMLGCTYLY---
..       |..|....||..         |.||||| ..|||.|.|..|.|..  ..  ...| .|...   ...  . |||| . ||.||  .|.   
llrpelagsGtTavvalirgn........klyvanvGDSravllrngelvqltvdhkpv.nelererilsaggavsh.grvngvlavtRalGdfdlklll

------PWILPKPHISSTPLT-IQDELLILGNKALWEHLSYTEAVNAVRH----VQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLN
      |.. . |......||  .|..|.|.   ||..||. |.|. ||.     .|. .||..|. || ..|..||. ..||.||
slllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrln
subfamily_PHLPP_pd Subfamily PHLPP 781-1034 7.9e-125 407.6 In-house 2-246 (246) alignment 
Range on Protein: 781-1034
Range on HMM: 2-246/246.0
STFWSHGLAEMAGQRNKLCVSALamdsfaeGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYI
....|.||.|.||..|||||.||       .|.|.||.|||||||||..|||..|.|||.||||...|....|.||.||..||||.||.||||.|||..|
lavfsiGlsesaGvknklcvaal.......svealyGlfdGdrneelssllqrlmkdvlkeevqkdkneeeymkntllvaqrklGeaGeklgsaallili

RPDTADPASSFSLTVANVGTCQAVLCRGGKPVPLSKVFSLEQDpeEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELL
|.|..|||.||||.||.|||.||||.|.||...|||....|.|  |..|.|..|||||||||.|||...||.||.|.|.|..|||||.....||.|||||
rhdkvdPaksfsLevAsvGtlqavliRngkklrlsksyviekd..elkrikeakaiitednkingviestrllGytflfPvvlPkphvrevlLteqdell

ILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLN
|.|||||||.||..|||.|||...|||.|||||..||||||..|.|...||.|.
ivGnkalWevlsideaveavrkeedplvaAkklvdlaqsygaadsvsvlvvrlr
PP2Cc_SM00332 784-1031 7.3e-34 110.4 In-house 10-274 (274) alignment 
Range on Protein: 784-1031
Range on HMM: 10-274/274.0
WSHGLAEMAGQRNKLCVSALAMDSF-AEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQSTND-----TVFMANTFLVSHRKLGMAGQ-------K
.|.|...| |.|..         ..  |  ....| |||   .| .....  . . | || .. ...     .  ... ||  . ..  . |       .
lsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelenal

LGSSALLCYIRPDTadpassfsLTVANVGTCQAVLCRGGKPVPLSKVFSLeQDPEEAQRVKDQKAIITEDnKVNGVTCCTRMLGCTYLY-------PWIL
 ||.|...... ..        | ||||| ..|||||.|| |.||.  .  .|..| .|.|.... .  . .|||.   .| .|  .|        | | 
sGstavvallkked........lyvanvGDSravlcrngkavqlsvdhkp.edederkRikkaggvvekg.rvngglavsrafGdhflkknkklkepyit

PKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQ------DPLAAAKKLCTLAQSY-GCQDNVGAMVV
..|... . || .||.|||    ||..||  |.|. ||         || .||..|. .|... |..||. ..||
aepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 785-1033 9.2e-25 80.4 In-house 7-253 (255) alignment 
Range on Protein: 785-1033
Range on HMM: 7-253/255.0
SHGLAEMAGQRNKLCVSALAMDSFAEGVGA-VYGMFDGDRNEELPRLLQCTMADVLLEEVQQS-TNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRP
  | ..| |.|. .  .  .  || .. .  .| .|||   ..  .    ..  .| | ..   .|    . ...   . ...  .. .|..|   .|  
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserpkfiGttaasvliie

DTadpassfsLTVANVGTCQAVLC-RGGKPVPLSKVFSlEQDPEEAQRVKDQKAIITED---NKVNGVTCCTRMLGCTYLYPWILPKPHIS-STPLTIQD
|           .||||  ..||| . |  . ||      ....| .|...    . ..    .|||    .| || ..| |...|.|..| |   ...|
dk........vyianvGdsrvvlcqkdgtakrlsldhk.PseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkd

ELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYL
. |||    .|. .|  |||. |  ..||  ||.||  || | | .||.  .|. |
kflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisvivikl
subfamily_PPM1A_pd Subfamily PPM1A 786-1034 2.5e-14 46.3 In-house 14-281 (282) alignment 
Range on Protein: 786-1034
Range on HMM: 14-281/282.0
HGLAEMAGQRNKLCVSALAMDSFAEG-VGAVYGMFDGDRNEELPRLLQCTMADVLLEE-------VQQSTND--TVFMANTFLVSHRK---LGMAG---Q
 |...| | |..   .  .. |...   .. . .|||   .|  .  . .. . .|||        ..|..|     . . ||  . .   |       .
ygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlktad

KLGSSALLCYIRpdtadpasSFSLTVANVGTCQAVLCRGGKPVPLSKVFSlEQDPEEAQRVKDQKAIITeDNKVNGVTCCTRMLGCTYLYP---------
| || |. . ..          .| .||.| . |||||.|| . |..     ..|.| .|...    ..  ..|||    .| ||   .           
ksGsTavtvlvs........ekhliianlGDsRavlcrngkaaflteDHk.psrpkEkkRieqAGGsvv.vsRvnGaLAvsRalGDyeykeeeekkaeeq

WILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHV----QDPLAAAKKLCTLAQSYGCQDNVGAMVVYLN
 . ..|.. |.  . .|. |.|    .|. ||  |.|. ||.     ... . ||.|   | . | .||. ..|| ..
lvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
subfamily_PPM1E_pd Subfamily PPM1E 813-1034 3.3e-22 71.9 In-house 40-263 (265) alignment 
Range on Protein: 813-1034
Range on HMM: 40-263/265.0
GAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQSTNDTVFMANTFLVSHRKLGMA----GQKLGSSALLCYIRPDTadpassfsLTVANVGTCQAVLCRG
 |....|||    |  .  .  .  .| .. .. .. .  . ..| .  ...       . | || |  . |. |.        | || .|  ||.|.| 
raffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklksGstavvvliekdq........lyvaWlGDsqallvrk

GKPVPLSKVFSLEQdPEEAQRVKDQKAIIT--EDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVR-HVQ-
|. | | |  . |. ..|..|...   ..   .  .||||   .| .| . | |..  .. .....|. ..|.|||.   ||...   |.|..|. ... 
geavqlmkpHkPer.edEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveeflad

---DPLAAAKKLCTLAQSYGCQDNVGAMVVYLN
   |   .||.|.. |.. | .||. ..||.|.
gaedlsevakllveaakeagssDnitvvvvfld
0049733 PP2C-like 814-1033 4.8e-24 78.1 In-house 27-233 (235) alignment 
Range on Protein: 814-1033
Range on HMM: 27-233/235.0
AVYGMFDGDRNEELPRLLQCTMADVL--------LEEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTadpassfsLTVANVGTCQAVL
......||  . .  ...  .. ..|        |......  ... .||. |... .     .  |..|.........        |.||||| . |.|
llfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTavvalldggk........lyvanvGDsrayl

CRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIitednKVNGVTCCTRMLGCTYLYpwilpkPHISSTPLTIQDeLLILGNKALWEHLSYTEAVNAVRHvQD
.|.|| |.|..  |. .. | . ... . |.      |.|. . ||.|| ..|       |......|. .| .|.|    ||..||  |.|. .|. .|
lrdgklvqltedhspvnelerqriitaggav.....rvpgrlaltralGdlllk......pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.ld

PLAAAKKLCTLAQSYGCQDNVGAMVVYL
. .||..|. || ..| .||. ..||.|
leeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1G2_pd Subfamily PPM1G2 841-1005 3.6e-06 19.1 In-house 87-248 (287) alignment 
Range on Protein: 841-1005
Range on HMM: 87-248/287.0
EEVQQSTNDTVFMANTFLVSHRKlgMAGQKLGSSALLCYIRPDTadpassfsLTVANVGTCQAVLCRGGKPVPLSKVFSlEQDPEEAQRVKDQKAIItED
....|  .|..   .. |....|  .. .. || |.   |. .         | |||.|  .|||.  |.   ||      |. .|..|....  .. | 
galeqilkdafletDeellkdek..lkdesaGstavvvlikeek........lyvanaGDsravlsskgnvkalsfDhk.PqeesekkriiaagGfv.el

NKVNGVTCCTRMLGCT-YLYP--------WILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQD
|.|||.    | ||   .            .   | .  . |. .|| |.|    .|. |. .| |. ||.   
nrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlv
PP2C Protein phosphatase 2C 849-1026 9.2e-32 103.6 Pfam-A 72-255 (255) alignment 
Range on Protein: 849-1026
Range on HMM: 72-255/255.0
DTVFMANTFLV----SHRK-LGM-AGQKLGSSALLCYIRPDTadpassfsLTVANVGTCQAVLCRGGKPV-PLSKVFSLEqDPEEAQRVKDQKAIITEDN
.   . ..||     ....   . . .| ||.|....||...        | |||||...|||||.....  |..  . . |..|..|....   . . .
vekalrksfladtdeelksskantepsksGstavvalirgkk........lyvAnvGDSravLcrkdnakkeltedHkps.dedEreRIeeaggsvsnng

KVNGVTCCTRMLGCTYLYP----WILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQD----PLAAAKKLCTLAQSYGCQDNV
.|||.   .|.|| ..|.|    .. ..|...|..|| .|| |||..  ||..||..|||  ||   .    |  ||..|.. |...|..||.
rvngsLavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 849-1026 9.2e-32 103.6 In-house 72-255 (255) alignment 
Range on Protein: 849-1026
Range on HMM: 72-255/255.0
DTVFMANTFLV----SHRK-LGM-AGQKLGSSALLCYIRPDTadpassfsLTVANVGTCQAVLCRGGKPV-PLSKVFSLEqDPEEAQRVKDQKAIITEDN
.   . ..||     ....   . . .| ||.|....||...        | |||||...|||||.....  |..  . . |..|..|....   . . .
vekalrksfladtdeelksskantepsksGstavvalirgkk........lyvAnvGDSravLcrkdnakkeltedHkps.dedEreRIeeaggsvsnng

KVNGVTCCTRMLGCTYLYP----WILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQD----PLAAAKKLCTLAQSYGCQDNV
.|||.   .|.|| ..|.|    .. ..|...|..|| .|| |||..  ||..||..|||  ||   .    |  ||..|.. |...|..||.
rvngsLavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
subfamily_PPM1G_pd Subfamily PPM1G 858-1002 7.9e-11 34.6 In-house 283-427 (473) alignment 
Range on Protein: 858-1002
Range on HMM: 283-427/473.0
LVSHRKLGMAGQKLGSSALLCYIRPDTadpassfsLTVANVGTCQAVLCRGGKPVPLSKVFSLEqDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGC-T
| .. .    |.. |. |  . .. ..        |.|||.| . .||.| || . ||     | |..|..|..     ..|| .|||     | ||  .
ldgseekeepGedsGttAvvaLlkekk........livAnaGDsRcvlsrnGkAldlslDHkPe.DevEleRiekAGGkvdedgRvnGGLnlsRAlGDha

YLYPWILP--------KPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRH
|     ||         | |  . || .|| |.|    .|  ..  | |. ||.
YkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvra
PPM_PTC7_SpoIIE 861-1025 5.9e-15 48.7 In-house 81-229 (230) alignment 
Range on Protein: 861-1025
Range on HMM: 81-229/230.0
HRKL--GmaGQKLGSSALLCYIRPDTadpassFSLTVANVGTCQAVLCRG-GKpvplskvfsleqdpeEAQRVKDQKAI-I-TEDNKVNGVTCCTRMLGC
...|      .. |..|....|.|.|        |.|||.| . ..|.|. |.               |. |..   .. .  ... |.||. ...  | 
aadlede..psssgaTavvalidpst......gklyvanaGdsppllvrddgg...............ererivagglpslGilpgrvfgvlavslapGd

TYLYP---WILPKPHiSSTPLTIQ-DELLILGNKALWEHLSYTEAVNAVRHVQDPLaAAKKLCTLAQSYGCQDN
..|..    . ..|. .|. .. . ||.|||....||..||  |.| .||   ... ||..| . ...... ..
llllytDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.aaeglleDDitllvvrv
PPM_PTC7 867-1026 1e-30 100.0 In-house 97-259 (259) alignment 
Range on Protein: 867-1026
Range on HMM: 97-259/259.0
AGQKLGSSALLCYIRPDTadpassfsLTVANVGTCQAVLCRGGKPV-PLSKVFSLEqDPEEAQRVKDQKAIIT--EDNKVNGVTCCTRMLGCTYLYP---
. .. ||.|....|....        | |||||...|||||.|..| .|.. .. . ...|..|...    .   ....||||   .|..| ..|.|   
epstsGstAvvalitgsk........lyvAnvGDSravLcrsgnavkqltedHkps.nedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket

---WILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQD---PLAAAKKLCTLAQSYGCQDNV
   .. . |.||||... .|| |||..  ||...|. |||  || . .   |  ||.||.. |...|..||.
eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 872-1033 1.1e-16 53.5 In-house 105-276 (276) alignment 
Range on Protein: 872-1033
Range on HMM: 105-276/276.0
GSSALLCYIRPDT--ADPASSFSLTVANVGTCQAVLCRGGKPVPLSKVFSlEQDPEEAQRVKDQKAIITED-NKVNGVTcCTRMLGCTYLYP---WILPK
|..| |. .  |    .      | |||||   | |.|| . . |||     .|||| ||.||.   ....  ..||..  .| ||  ..      .  .
GatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhk.atdpeekqrikddGitlsdnqtrinGla.vsralGdhfikelniGlise

PHISST-PLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKL-----CTLAQSYGCQDNVGAMVVYL
|..|.   || .|. ||.    ||. .|  .|.. |. . |  |...|.      |  ||  ..|||  .|| |
pyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_KAPP-like_pd Subfamily KAPP-like 872-1033 3.5e-16 52.0 In-house 101-266 (266) alignment 
Range on Protein: 872-1033
Range on HMM: 101-266/266.0
GSSALLCYIRPDTadpaSSFSLTVANVGTCQAVLCRGGKPVPLSKVFSlEQDPEEAQRVKDQKAIITED-NKVNGVTcCTRMLGCTYLYP---WILPKPH
|..| |. .  |         | |||||   | |.|| . . |||     .|||| ||.||.   ....  ..||..  .| ||  ..      .  .|.
GatatlalvwsdG....qqrylqvanvGdssaflsrGneslelskdhk.akdpeekqrikddGitlsdnqtrinGla.vsralGdhfikelniGlisepy

ISST-PLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKL-----CTLAQSYGCQDNVGAMVVYL
.|.   || .|. ||.    ||. .|  .|.. |. . |  |...|.      |  ||  ..|||  .|| |
vsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_PPM1L_pd Subfamily PPM1L 891-1033 6.3e-14 44.9 In-house 118-266 (269) alignment 
Range on Protein: 891-1033
Range on HMM: 118-266/269.0
FSLTVANVGTCQAVLCR-GGKPVPLSKVFSlEQDPEEAQRVKDQKAIITED--NKVNGVTCCTRMLGCTYLY--PWILPKPHISSTPLT-IQDELLILGN
  |.|||||  . ||.   || .|||      |...| .|.|.   .|. .   .|.||   .| ||   |     ....| | .  |   . |.|||  
sdlivanvGdsrGvlydkrGkaiplsfdhk.pqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdlddhkpeflilas

KALWEHLSYTEAVNAV-RHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYL
  ||. .|  |||. .  ....|   || |   .   |. ||.  .|| |
dGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvkl
subfamily_PPM1K_pd Subfamily PPM1K 892-1033 8.4e-16 50.9 In-house 112-258 (263) alignment 
Range on Protein: 892-1033
Range on HMM: 112-258/263.0
SLTVANVGTCQAVLCRGGKPVPLSKVFSLEQDPeEAQRVKDQKAIITE----DNKVNGVTCCTRMLGCTYLYPW-ILPKPHISSTPL-TIQDELLILGNK
 | .|..|  .|.||| ||.  |..  . |..  | .|.|     ..       .|||. . || ||   | .. .. .|.  |  .   .| .|.|   
elvlaslGdsrailcrnGkakkltrdhdPelee.ekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitd

ALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYL
 .   ..  |  . ||  .||  ||. |.. |  ||..||. |.|| |
gisfvvnsqelcdlvrlchdpeeaahalteqalqygsednatavvvpl
subfamily_PP2D1_pd Subfamily PP2D1 893-1002 4.7e-14 45.0 In-house 190-304 (492) alignment 
Range on Protein: 893-1002
Range on HMM: 190-304/492.0
LTVANVGTCQAVLCRGGKPVPLSKVFSLeQDPEEAQRVKDQKAIITEDN---KVNGVTCCTRMLGC---TYLYPWILPKPHISSTPLTIQDELLILGNKA
| .||.|  ||||||.|| . | .   . ....| .||. . ..... .   .|||..  || ||    . |   ..|.|.. |..|. .. .|.|    
lyianaGnvqAvLcreGkaiiLtreHtp.rnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnG

LWEHLSYTEAVNAVRH
||| ||  | .. |..
lWevlseeevlsLvkq
subfamily_ILKAP_pd Subfamily ILKAP 893-1005 4e-08 25.8 In-house 127-244 (293) alignment 
Range on Protein: 893-1005
Range on HMM: 127-244/293.0
LTVANVGTCQAVLCRGGKP------VPLSKVFSLEqDPEEAQRVKDQKAIItEDNKVNGVTCCTRMLGC-TYLYPWILPKPHISSTPLTIQDELLILGNK
| |||.|  .|||.|  .       |.|.|  .   . || .|..   . . .|..|.||   .| .|   .    .  .|...   ||  |  ..|   
lyvanlGdskavlvrkkeegdkiasvvLtkdhtpv.kyeerkriqkaGgvv.rdgrvlGvlevsrsiGdgrfkrlGvistPdvkkceLtendlfvvlaCd

ALWEHLSYTEAVNAVRHVQD
 ||. .|  |.|. . .| .
GLwkvfsadevvkfilkvle
PPM_PTC7_motif 981-1026 3.9e-08 26.7 In-house 1-51 (51) alignment 
Range on Protein: 981-1026
Range on HMM: 1-51/51.0
ILGNKALWEHLSYTEAVNAVRHVQD-----PLAAAKKLCTLAQSYGCQDNV
||..  ||..||. |||. ||   .     |  ||.||.. |...|. ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni