Gene PPM1B in Homo sapiens

Synonym: PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX, PPM1B

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP175_AA protein Get Run
HsapP175_AA_2-298 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 3-298 1.3e-90 295.9 In-house 2-293 (295) alignment 
Range on Protein: 3-298
Range on HMM: 2-293/295.0
AFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRaagksGSALELSVENV
..|..|..|... .   . ||.| .|.||.| ..|||...|......|||...|.|.||| |...|...| .|.|..  .            |.|| |..
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekl.....lllltlsledi

KNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRAL
.. .|..||..||.... . ||. ...||.||| ..| ....|. |.|||||||.|||.. . | |||| |. |.|||..||| |.  ||||.|||.|||
eealrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRal

GDYDYKCVDGKGPTEQLVSPEPEVYEILRA-EEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNA
||.|.|..    ..|.|||.||.|. . .  |.|.|..||.||.|||.||||....|.|.|. ..|||.... .|| .|..|||||...|.|.... 
GdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlngl
subfamily_PPM1G_pd Subfamily PPM1G 4-96 1.9e-26 86.1 In-house 1-89 (473) alignment 
Range on Protein: 4-96
Range on HMM: 1-89/473.0
FLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPhglEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAaGKSGSALE
.|.|||.||.. ... ..|.|| |.||||||..||||.... .    ||.|.||||||| |. ||.|....|.. .. .. ... |.  .|||
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdld...edtslfavyDGHGGkevakyvakklpdllkaqkgyke.gdvekale
subfamily_PPM1G2_pd Subfamily PPM1G2 5-295 4.3e-84 274.9 In-house 2-286 (287) alignment 
Range on Protein: 5-295
Range on HMM: 2-286/287.0
LDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTA---VVGIPHGlEDWSFFAVYDGHAGSRVANYCSTHLLEHITTnedfraagksgsALELSVEN
|..| ..|..| .| .  . | |.|||.|..|||||.    ..  .   .. ..|||.||| |..||.|....| . |..              ... ..
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksdd.kslalfavfDGhGGakvakyagkklikkiak............kksfkega

VKNGIRTGFLKIDEYMRNFSDLRNgmDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRA
... .. .||..|| ... . |..  . .||||| |.|. ...|  |.|||||||  .|.|   . |||| .  ||.||..||| | ..||||.||.|||
leqilkdafletDeellkdeklkd..esaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsra

LGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSR------DNMSIVLVCF
|||. .|  . |.| ||.|  .|.|    . |.|||..|||||||||..|.|....|..||    .|..... ..|.|| . |.      |||..|.|..
lgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
subfamily_PPM1A_pd Subfamily PPM1A 8-296 1e-130 428.2 In-house 3-281 (282) alignment 
Range on Protein: 8-296
Range on HMM: 3-281/282.0
PktekhNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPhGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAagksGSALELSVENVKNGIR
|     .... |||||||.|||||||||||||||.|. .. .|.|||||||.||||||.||.|...||||.|...|....     .. . . ..||...|
p.....ksqaegnglrygvssmqgwrvemEDahtvvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelke....aaleasekdevkealr

TGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDY
.|||..|| .|. |.  ...|.||||||.|..|.||....|.|||||||.|||...|.|.||||..|.||.||..|||||...||||.||||||||||.|
qgfLaldeairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyey

KCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFS
|. . |...|||||.||||. | | |||.|..|||||||||.|.||..|.|..||||.|.||.|.. .||..|.||||||.|...|.|.
keeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
PP2Cc_SM00332 14-293 1.9e-81 266.5 In-house 2-274 (274) alignment 
Range on Protein: 14-293
Range on HMM: 2-274/274.0
NAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPhGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKsgsalelsVENVKNGIRTGFLKI
. .| ..||.||.|||||||..|||||  ||      |||.||.|.|||.||.||...| .| |..  .  . .  .         ..|.. ....||..
sesgsnlglsygkssmqgwrksmeDahvvvvdlv.eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel........eddveealkkaflst

DEYMRN-FSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDg
|| ..   . ... . .|||||| .... ...|. |.|||||||.|||..   ..|||| ...|..||..|||.|. .||||.||||||.||...|  . 
deeileeeqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk.

kGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRL--EVSDDLENVCNWVVDTCLHK-GSRDNMSIVLV
 ...|. ...||.|. .   .||||.|||.||.|||.||.|....|...|  ..  | ..... ... .. . ||.||...|.|
.klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
0049733 PP2C-like 22-296 2.7e-64 209.5 In-house 3-234 (235) alignment 
Range on Protein: 22-296
Range on HMM: 3-234/235.0
LRYGLSSMQGW-RVEMEDAHTAvvgiphgleDWSFFAVYDGHAGSRVANYCSTHLLEHITTNE-DfraagksgsaleLSVENVKNGIRTGFLKIDEYMRN
|..| .|..|. | ..|||. .         ....|||.||| |.......| .|.|..     .            |. ..... .|  ||...|....
lsvgaasdigrvrkvneDavlv.........glllfavaDGhgghaagevasellvetllellle............lllldleealrkaflaanealle

FSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVmiqRVNGSLAVSRALGDYDYKcvdgkgpteql
 .  .......|.||| ... ....|..|.|||||.|.|.|.. . |.||.| |. |..||..||| |   ||.|.||..|||||...|           
lalaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...........

vspePEVYEILRAEEDeFIILACDGIWDVMSNEELCEYVKSrlevsDDLENVCNWVVDTCLHKGSRDNMSIVLVCFS
    |.|...   ..| |..||.||.|||.|.||......|     .|||......|...|..|.|||...|.|...
....pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 22-296 5.4e-46 149.9 In-house 6-254 (255) alignment 
Range on Protein: 22-296
Range on HMM: 6-254/255.0
LRYGLSSMQGWRVEMEDAHtAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAgKSGSALELSVENVKNGIrtgflkideymrnfs
.. | | | | |  |||   .. |  .. .|  ..|..|||.|.. |...| .|   ..   |   | .   .|. . ....  |               
fkvgfsdmiGrrptmedel.viyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnna.nPvkslkkaykeistqi...............

dlR--NgmDRSGSTAVGVMISPKHIYFINCGDSRAVLY-RNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ----RVNGSLAVSRALGDYdYkcvdgkg
         . |.||. |.|  ...|  | ||||.||  ..|     . |||| ...|..||...|| |. .    |||| |||||||||  .       
..serp..kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.f.......

pTEQLVSPEPEVY-EILRAEEDEFIILACDGIWDVMSNEELCEYVKSrlevSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFS
  |  | |.|..  ..   ..|.|.|||||||||..|.|| .| | .    . | |. .. . |   ..|| ||.|.... .|
.lePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivag....isdpekaaeklrdlayssGstdnisvivikls
PPM_PTC7 23-288 4.6e-84 274.9 In-house 2-259 (259) alignment 
Range on Protein: 23-288
Range on HMM: 2-259/259.0
RYGLSSMQGWRVEMEDAHTAVVGIP--HGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGksgsalelsveNVKNGIRTGFLKIDEYMRNF
..| |..||.|..|||||.|  .     | ....||||.|||.|...|.|...|| |..  ...|.              ......|..||..|  ... 
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele...........klekalrksflaldtdeelk

SDLRN-GMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVC-FSTQDHKPCNPREKERIQNAGGSVM---IQRVNGSLAVSRALGDYDYKCVDGkgp
|.  | . ..|||||| ..|.....|. |.||||||| |.|..  . |.|||| |..|.|||..|||||.    .||||.||||||.||...|.      
sseantepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...

TEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSdDLENVCNWVVDTCLHKGSRDNM
.|||||.||..... . |||||.|||.||.|||.|..|... |.|.|.   |...... .||... .||.||.
eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
PP2C Protein phosphatase 2C 23-288 1.4e-83 273.4 Pfam-A 2-255 (255) alignment 
Range on Protein: 23-288
Range on HMM: 2-255/255.0
RYGLSSMQGWRVEMEDAHTAVVGIP--HGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGksgsalelsveNVKNGIRTGFLK-IDEYMRN
..| |..||.| .|||||.|        | ....||||.|||.|...|.|...|| |..  ...|. .            .|....| .||. .|| ...
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele...........kvekalrksfladtdeelks

FSDLRnGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVC-FSTQDHKPCNPREKERIQNAGGSVM-IQRVNGSLAVSRALGDYDYKCVDgkgptE
 .. .   ..|||||| ..|..|..|. |.||||||| |...   . |.|||| ...|.|||..|||||. ..||||||||||||||...|. .     |
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....e

QLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNM
||||.||.|... . |||||.|||.||.|||.|..|... |.|.|.  ........ .|| .. .||.||.
qlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 23-288 1.4e-83 273.4 In-house 2-255 (255) alignment 
Range on Protein: 23-288
Range on HMM: 2-255/255.0
RYGLSSMQGWRVEMEDAHTAVVGIP--HGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGksgsalelsveNVKNGIRTGFLK-IDEYMRN
..| |..||.| .|||||.|        | ....||||.|||.|...|.|...|| |..  ...|. .            .|....| .||. .|| ...
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele...........kvekalrksfladtdeelks

FSDLRnGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVC-FSTQDHKPCNPREKERIQNAGGSVM-IQRVNGSLAVSRALGDYDYKCVDgkgptE
 .. .   ..|||||| ..|..|..|. |.||||||| |...   . |.|||| ...|.|||..|||||. ..||||||||||||||...|. .     |
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....e

QLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNM
||||.||.|... . |||||.|||.||.|||.|..|... |.|.|.  ........ .|| .. .||.||.
qlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7_SpoIIE 23-264 4.7e-46 150.5 In-house 2-211 (230) alignment 
Range on Protein: 23-264
Range on HMM: 2-211/230.0
RYGLSSMQGWRVEMEDAHTAVVGIP--HGLEDWSFFAVYDGHAGSRvaNYCSTHLLEHITTNEdFRAAGksgsalelsveNVKNGIRTGFLKIDEYMRNF
..| |..||.| .|||||..  .     |   . .....||| |.    .....| . . ..  |. .            .... .| ..|...  ....
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle...........kpeeilrrlnlalaadlede

sdlrngMDRSGSTAVGVMISPKH--IYFINCGDSRAVLYRN-GQvcfstqdhkpcnprEKERIqNAGGSVM----IQRVNGSLAVSRALGDYDYKCvdgk
       . ||.||| . | | .  .|..|.|||...|.|. |.              |.|||  ||| ..     .||.|.||||.| ||. ...    
......psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly....

gpTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEV
  |...|..||.  ...  ..|||.|||.||.|||.|..||.. |...|| 
..tDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelek
Subfamily Dicty-PPM1L-like 23-126 4.7e-09 28.5 In-house 8-109 (305) alignment 
Range on Protein: 23-126
Range on HMM: 8-109/305.0
RYGLSSMQGWRVEMEDAHTAVVGIPHGlEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSvENVKNGIRTGFLKIDEYMRNFSD
.|.|   .. |   || .   ...    .. |.| |.||| | . |.|   .|.| .        .|.|   |  . .   . |. ..|. |... ....
kyelyvsansrkyqedrnkvkisless.qelslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvd.dlpleaiksaslstdkssldsae

LRNG
  |.
sdnk
subfamily_PPM1K_pd Subfamily PPM1K 25-296 1.5e-37 122.1 In-house 7-259 (263) alignment 
Range on Protein: 25-296
Range on HMM: 7-259/263.0
GLSSMQGWRVEMEDAHTavvgIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDfrAAGKSGSALELSVENVKNgirtgflKIDEYMRN-FSDL
|  |..| | | ||  .    . .  ..  ..||.||||||  |... ..| .....  .     .    |  . |....       |.  |..  ... 
GkdsliGkraenedrik....lkeldpellyvavfdGhaGsaaadfvhdklekilkrlle..kekdleivlknafeeldk.......klkrylefsvaea

rnGMDRSGSTAVGVM-ISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMI-----QRVNGSLAVSRALGDYDYKCVdGkgpte
   .  ||.||  ..    ...   . |||||.| |||.    |.||.|    |||||..|||||        .||| ||..|.||| | |   |     
..ellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkry.G.....

QLVSPEPEVYEIlRAEEDEFIILACDGIWDVMSNEELCEYVKsrleVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFS
 .  ||    .. . ..| |..|  ||| .|....|||..|.    .  | |.  . .... |  || || ..|.| . 
viatPetkslkv.dhaadsflvlitdgisfvvnsqelcdlvr....lchdpeeaahalteqalqygsednatavvvplg
subfamily_PPM1E_pd Subfamily PPM1E 27-295 2.4e-55 180.6 In-house 9-262 (265) alignment 
Range on Protein: 27-295
Range on HMM: 9-262/265.0
SSMQGWRVEMEDAHTAVVGIPHGLE-----DWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKsgsalelsvenvkNGIRTGFLKIDEYMRNFS
 .... |  ||| | |.  . . .|     . .||||.|||.|.  |.| ..|| |..  .|..    .             . .. .| ..|| . . .
aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.............ealkeafkltDerflqka

DlRNGMdRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMI---QRVNGSLAVSRALGDYDYKcvdgkgpteQ
  |... .|||||| |.|. ...|    |||.|.| |.|..   .. ||| ...||.||..||| |.     ||||.|.||||.||...|         .
e.rekl.ksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........p

LVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSD-DLENVCNWVVDTCLHKGSRDNMSIVLVCF
 || |..| |.   ...|..||||||.|||. .||... |.. |. .  ||..| . .|..  ..||.||...|.| .
yvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
subfamily_PPM1D_pd Subfamily PPM1D 27-296 9.1e-40 129.6 In-house 7-308 (309) alignment 
Range on Protein: 27-296
Range on HMM: 7-308/309.0
SSMQGWRVEMEDAHTAVVGIPHGL--EDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFraagksgsaLELSVENVKNGIRTGFLKIDEYMRNF----
.. || |  |||  . |.   . .   ...|.||.||| |   |.. . ||.. |. ...|         |  . |.| . || .||.. | |..     
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf.........lssepedvleAireaflatheamkkkleeW

SDLRNGM-DRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQ------VCFSTQDHKPCNPREKERIQNAGGSVMIQ----RV---------NGS-----
.  ..|    .|.||  |.|  ...|  . |||..||  . .          |.|||| .|.|||||...||.|...    ||         ||      
pktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvide

---LAVSRALGD-YDYKCVDGkgptEQLVSPEPEVYEILR-AEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSD----DLENVCNWVVDTCLHKGSR-
   |||.|.||| . |.   |    | .|||||.|..  .  .|..||||| ||.|.|.. |.  . |..  |..       ..| . .|.. |.. .. 
iPFLavaRslGDlWsynaksg....efvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrsk

----DNMSIVLVCFS
    ||.|...|...
klraDnvsvivvile
subfamily_ILKAP_pd Subfamily ILKAP 28-292 8e-42 136.4 In-house 11-289 (293) alignment 
Range on Protein: 28-292
Range on HMM: 11-289/293.0
SMQGWRVEMEDAHTAVVGIPH-------GLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNedFRAagKSGSALElsvENVKNGIRTGFLKIDEYMRNF
  .| | ||.|||. .  . .        ..  |..||.||||||| ..... .| ..| ..  .    .. || |   ...|. .   | | || . . 
erkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek..lpk..sdvsake...keikkclvdsfkktdeefLkl

SDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRN---GQ---VCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVdGkg
.   . . . ||||. |..  . .|  | |||.|||.|.   |.   .   |.||.| .  |..||| |||.|   ||.| | |||..||  .| . |  
askakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrl.G..

pteqlVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDL----------------ENVCNWVVDTCLHKGSRDNMSIVL
     |.  |.|  .   | | |..|||||.|.|.|..|  ... . ||  .|                 | .|| .    ...|| ||....|
.....vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvll
subfamily_PPM1L_pd Subfamily PPM1L 28-297 1e-41 136.0 In-house 11-268 (269) alignment 
Range on Protein: 28-297
Range on HMM: 11-268/269.0
SMQGWRVEMEDAHTAVVGIPHGLEdWSFFAVYDGHAGSRVANYCSTHLLEHITTNE-DFrAAGKSGSaLELsveNVKNGIRTGFLKIDEYMrnFSDLRNG
|..| | .|||  .   .| .. .  |||||.||| |   |...   | . | ..  .. .| |  . . .   | .. .    | .|| .     ... 
svlGrrprmedrfeieediknktg.esffavfdGhGGefaaefakdvlvkaiknkliel.dadkent.epi...nfsklltdeilsvdekl..lekakra

MDRSGSTAVGVMISPKHIYFINCGDSRAVLY-RNGQVCFSTQDHKPCNPREKERIQNAGGSVMI---QRVNGSLAVSRALGDYDYKcvdgkgpTEQLVSP
.| .|.||.  ... ...   | |||| ||| ..|.    . |||| ...|. ||..||| . .    ||.| ||.|||||||  |        ..|| .
ediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.......dknlvia

EPEVYEI-LRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDdleNVCNWVVDTCLHKGSRDNMSIVLVCFSN
.|..  . |   . ||.|||.||.|| .|||| ....| ||.  |        .|  . ..|| ||.....| ..|
dpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepd...fGakslvlesfkrGsvdnitvlvvklkn
subfamily_PP2D1_pd Subfamily PP2D1 32-77 7.2e-06 18.0 In-house 13-57 (492) alignment 
Range on Protein: 32-77
Range on HMM: 13-57/492.0
WRVEMEDAHTAVVGIPHGlEDWSFFAVYDGHAGSRVANYCSTHLLE
|. .|||..| .        . .||..|||. |.  |. ....| |
WKskmeDkrtlqdyfgnd.vnscFfgiyDGynGataAeiaakelhe
subfamily_KAPP-like_pd Subfamily KAPP-like 35-293 1.9e-24 79.1 In-house 11-264 (266) alignment 
Range on Protein: 35-293
Range on HMM: 11-264/266.0
EMEDAHTAVVGIPHGLE-----DWSFFAVYDGHAGSRVANYCStHLLEHITTNeDFRA-AGKSGSAlelSVENVKNGIRTGFLKIDEYMRNFsdlrngmD
|||| . |.  . .  .     . ..|||.|||||  .|.  . .|....  .   .    . |     .. . .. ..  | ..|. ...|       .
emedvslaiypllkekklsncsnialfavfdGhaGkGaadaak.klfpkelek.llkstkqddGGd...niydqskllenafkevdaklkdf.......e

RSGSTAVGVMI-S---PKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVM--IQRVNGsLAVSRALGDYDYKCVDGKGPTEQLVSP
  |.||  ... |    ...   | ||| | | |  .  . ..|||  .|.|| ||.. | ..     |.|| |||||||||.  |  .    .|  ||.
yeGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsn

EpevyeILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHK-GSRDNMSIVLV
.     || .  |.|.|.| ||.|||.| ..  | |||  .  .  ..... ...| ..   ..||.|...|
r.....illtpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 48-204 5.2e-16 52.0 In-house 15-182 (292) alignment 
Range on Protein: 48-204
Range on HMM: 15-182/292.0
HGLEDWSF-FAVYDGHA--GSRVANYCSTHLLEHITtnEDFRAAGKSGSALELSVenvkngiRTGFLKIDEYMrnfSDLRngmdRSGSTAVGVMISPK--
.| |  .|  ||.|||   | .||..   .|  ...  | .|   .   || | .            |.|. .    | |     |..|||   . .   
egsealtflaavldGhGvnGdkvaqlaedtlevell..eltrqlqelsealllri.......ldiaakldklt...idar....esattavvcarvrddr

HIYFINCGDSRAVLYR-----NGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ-----------RV------NGSLAVSRALGD
 ..  | |||||.|.|     . ..   ..|||| .| |..||..||| |              ||      .| ||.||||||
alilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGd
PP2C_2 Protein phosphatase 2C 50-263 1.4e-09 30.5 Pfam-A 21-196 (212) alignment 
Range on Protein: 50-263
Range on HMM: 21-196/212.0
LEDWSFFAVYDGHAGSRVANYCSTHLLEHIttNEDFRAAGKSGSAL--ELSVENVKNGIRTGFLKIDEYMRNfsdlRNGMDRSGSTAVGVMISPKHIYFI
 .|....|| ||.   . .   .  . | .   | ...  ...|.   |  .....|.|..   . .| . .    .. ..  ..| . ..|.|..|.|.
asdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqeeeallrqieneilasvklkqeaeaq....qeelkdyatTlllavitpgeivff

NCGDSRAVLY-RNGQVCFSTQDHKPCNPREKERIQNA--GGSVmiqrvngslavsralgdydykcvdgkgpteqlvspepeVYEILRAEEDEFIILACDG
..||...|.. |.|.|   .....    .|  ... .  ....                                       ...|..|. . ..|  ||
qiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel......................................rirrlklepgdalllmTDG

IWDVMSNEE-LCEYVKSRLE
..| ...|| . |... .||
vsdslrkeepfrellaelle
PP2C_2 Protein phosphatase 2C 50-263 1.4e-09 30.5 In-house 21-196 (212) alignment 
Range on Protein: 50-263
Range on HMM: 21-196/212.0
LEDWSFFAVYDGHAGSRVANYCSTHLLEHIttNEDFRAAGKSGSAL--ELSVENVKNGIRTGFLKIDEYMRNfsdlRNGMDRSGSTAVGVMISPKHIYFI
 .|....|| ||.   . .   .  . | .   | ...  ...|.   |  .....|.|..   . .| . .    .. ..  ..| . ..|.|..|.|.
asdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqeeeallrqieneilasvklkqeaeaq....qeelkdyatTlllavitpgeivff

NCGDSRAVLY-RNGQVCFSTQDHKPCNPREKERIQNA--GGSVmiqrvngslavsralgdydykcvdgkgpteqlvspepeVYEILRAEEDEFIILACDG
..||...|.. |.|.|   .....    .|  ... .  ....                                       ...|..|. . ..|  ||
qiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel......................................rirrlklepgdalllmTDG

IWDVMSNEE-LCEYVKSRLE
..| ...|| . |... .||
vsdslrkeepfrellaelle
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 52-293 1.8e-22 72.5 In-house 32-274 (276) alignment 
Range on Protein: 52-293
Range on HMM: 32-274/276.0
DWSFFAVYDGHAGSRVANYCSTHLLEHITT---NEDFR-AAGKSGSAlelSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVG---VMISPKHI
. ..|||.|||||  .|.  .  . . .       ..  .  . |     .. . .. .   | ..|. ...|         .     |        ...
nialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGd...niydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqqqqqryl

YFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVM--IQRVNGsLAVSRALGDYDYKCVDGKGPTEQLVSPEpevyeILRAEEDEFIILAC
   | ||| | | |  .  . ..|||  .| ||.||.. | ..     |.|| |||||||||.  |  .    .|  ||..     || .  |.|.|.| 
qvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnr.....illtpfdkflivas

DGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHK-GSRDNMSIVLV
||.|||.| ..  | |||  .  .  ..... ...| ..   ..||.|...|
dGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
PP2C_SIG_SM00331 55-293 5.1e-15 48.6 In-house 32-215 (217) alignment 
Range on Protein: 55-293
Range on HMM: 32-215/217.0
FFAVYDGHAGSRVANYCSTHLLEHITTNEDFRaagksgSALELSVENVKNGIRTGflkideymrnfsdlrNGMDRSGSTAVGVM--ISPKHIYFINCGDS
...| ||. .   |. .|  |.. . .  . .      ..|.  ....   |.                 .. .... |..  .  .| ......|.|||
llvvaDgmGkGlaAaaassqlrtalrellseg......eelsqalkrlnraiyee...............keekgmfaTlllalydfssgklsyanaGds

RAVLYRNGQVCFSTQDhkpcnprekeriqnaggsvmiqrvngslavsralgdydykcvdgkgPTEQLVSPEPEVY---EILRAEEDEFIILACDGIWDVM
| .|.|.|. .. ..|                                              .. .... ||||    . |  |......|. ||.....
rpyllrdgklveilkd..............................................vegaplGlepevsvdirelelekgdllllytDGltear

S-----NEELCEYVKSRL-EVSDDLEN-VCNWVVDTCLHKGSRDNMSIVLV
|     .|.|.| ... . . ...| .   . .. .   .. .|....|.|
sekgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvv
subfamily_PDP_pd Subfamily PDP 94-271 1.1e-20 67.1 In-house 107-321 (398) alignment 
Range on Protein: 94-271
Range on HMM: 107-321/398.0
ALELSVENVKNGIRTGFLKIDEYMR--NF-----SDLRN--GMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRN---GQVCF--STQDHKPCNPREKER
.||..||.||. ....|||.|. ..   .     ..||.   .  ||..|. ..|......  | ||.|||| ..   |..     ..|.   |..| ||
lleaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveR

IQNAG---GS---VMIQRVNGSLAVSRALGDYDYKCVD--GKGPTEQ----L-----------VSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCE
|...     |   .. .|. |.|. .|| ||. ||      | . |.                .. |||| .   .|.| |..|| ||.||..||||  .
ikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvs

YVKSRLEVSDDLENV
.|.  |. ... |.|
lVgehlakkkekepv
subfamily_PPM1H_pd Subfamily PPM1H 104-182 1.1e-08 27.3 In-house 138-212 (404) alignment 
Range on Protein: 104-182
Range on HMM: 138-212/404.0
NGIRTGFLKIDEYMRNfsDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNprEKERIQN
  . . ||..|| ...  . ..  .. | ||. ...  . .|  | |||||.| |....    .|. |    |..|.|.
GalesaflemDeqiar..ereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPet..eRqRlqe
subfamily_PP2D1_pd Subfamily PP2D1 122-266 3.3e-24 78.5 In-house 168-310 (492) alignment 
Range on Protein: 122-266
Range on HMM: 168-310/492.0
DLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVM----IQRVNGSLAVSRALGDYdykcvdGKGPTE
| ..|.... ..    .. .  .|  | |. .||| |.|.    |..| | |..|..|...||..|.      .||| | . | || |      | .  .
dseeGlekesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny......GdpkLk

QLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSD
. | |||..  .   |.. |..||  |.|.|.|.||  . ||. |..  
ksvipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyk
subfamily_PPM1G_pd Subfamily PPM1G 129-296 3.1e-49 161.2 In-house 295-471 (473) alignment 
Range on Protein: 129-296
Range on HMM: 295-471/473.0
RSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVM-IQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVY
 ||.||| ...  |...  | ||||.|| |||.      |||| .. |.|||..||| |    |||| | .||||||. ||     .. ||..|  |.. 
dsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDik

EILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSD--DLENVCNWVVDTCLHKGS------RDNMSIVLVCFS
  . .|||||..|||||||.||. .|  ..|...|. ..   |..... ..|.|| .         |||....|.. 
vltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllk
subfamily_TAB1_pd Subfamily TAB1 130-278 3.9e-11 35.3 In-house 129-298 (333) alignment 
Range on Protein: 130-278
Range on HMM: 129-298/333.0
SGSTAVGVMISPKHIYFINCGDSRAVLYR---NGQVCFSTQDHKPCNPREKERIQNAGG-SVMIQR--VNGSLAVSRALGDYDYK----CVDG-KGPTEQ
 |.||| ..|  ...| .|.|||||.| .   . .|    .||.  |. | .|... |     |.|  . ||    |..|||  |     ||  .  ...
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakge

LVSPEPEVYEILRAEEDE-FIILACDGIWDVMS--------NEE-LCEYVKSRLEVSDDLENVCNWVVDT
 |  ||..   .  .. . |..|  ||.   .         | | .   |. .|| . .|..| . ||| 
PviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqavvdk
subfamily_PHLPP_pd Subfamily PHLPP 146-293 3.3e-10 32.3 In-house 109-243 (246) alignment 
Range on Protein: 146-293
Range on HMM: 109-243/246.0
FINCGDSRAVLYRNGQ-VCFSTQDHKPCNprEKERIQNAGGSVMI-QRVNGSLAVSRALGDYDykcvdgkgpTEQLVSPEPEVYEILRAEEDEFIILACD
  . |   ||| |||. . .| ..   ..  | .||..| . .   ...|| .. .| || .          .   | |.|.| |.| .|.||..|.  .
vAsvGtlqavliRngkklrlsksyviekd..elkrikeakaiitednkingviestrllGytf.........lfPvvlPkphvrevlLteqdellivGnk

GIWDVMSNEELCEYVKSrleVSDDLeNVCNWVVDTCLHKGSRDNMSIVLV
 .|.|.| .|. | |.    . | |  .   .||     | .|..|.. |
alWevlsideaveavrk...eedpl.vaAkklvdlaqsygaadsvsvlvv
subfamily_PPM1H_pd Subfamily PPM1H 190-266 1.4e-12 40.1 In-house 275-355 (404) alignment 
Range on Protein: 190-266
Range on HMM: 275-355/404.0
QRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVY--EI--LRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSD
.|. . ..|.| |||.. | || .     ..||.|||   ..  .  .||. .||| ||.|||.||||  | |.. |.  .
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskve
Subfamily Dicty-PPM1L-like 191-295 7.3e-11 34.4 In-house 200-303 (305) alignment 
Range on Protein: 191-295
Range on HMM: 200-303/305.0
RVNGSLAVSRALGDYDYKCVDGkgpteqlVSPEPEVYEILRAeEDEFIILACDGIWDVMSNEELCEYVKSRLEVS---D----DLENVCNWVVDTCLHKG
.||. | .||  || . |..           .. ... . .| .|.|..|| ||.|.|.|.... | ||  |. .        | ... . .|   ...|
lvnrllkksrskGdknlkelvi.......Pnndspllvvaka.nDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrg

SRDNMSIVLVCF
|.||. .|.. .
sgDnitlviikl
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 217-295 6.5e-06 17.5 In-house 236-315 (317) alignment 
Range on Protein: 217-295
Range on HMM: 236-315/317.0
EQLVSPEPEVYE-ILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCF
   |. .|||.  .| ..|   ..   ||| | ...... . |       .  | .|.   | .| . | |. . |....
raGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcddaqdylldetsiddatavvlll
PPM_PTC7_SpoIIE_motif 232-295 2e-09 31.0 In-house 9-80 (81) alignment 
Range on Protein: 232-295
Range on HMM: 9-80/81.0
AEEDEFIILACDGIW-------DVMSNEELCEYVKSRlEVSDdLENVCNWVVDTCLHKG---SRDNMSIVLVCF
 .... ..|..||..       .....|||....... |. . |. ..  .||..|  |   ..|.........
LkpgdvllLyTDGltEardsdgelfgkeellrladra.egks.lqeladklvdevlengsgereDDitllvlrv
PPM_PTC7_motif 239-288 1.3e-15 50.6 In-house 1-51 (51) alignment 
Range on Protein: 239-288
Range on HMM: 1-51/51.0
ILACDGIWDVMSNEELCEYVKSRLE-VSDDLENVCNWVVDTCLHKGSRDNM
|||.||.|||.|..|... |...|.   ........ .||..| .|| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
PP2C_C Protein serine/threonine phosphatase 2C, C-terminal domain 289-369 3.6e-39 122.4 Pfam-A 1-81 (81) alignment 
Range on Protein: 289-369
Range on HMM: 1-81/81.0
SIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSR
||.||||..|||||.|||||..||||.||||||||.|||.||..|||..|.. |..|.||||||||||| ||.||||||..
siilvcfpgAPkvseeAvkkeaeLdkalesrveeiieksseeevpdllsvlktlasedipnLPPGGglasKrsvieavykk