Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
SIP1 | Survival motor neuron (SMN) interacting protein 1 (SIP1) | 84-161 | 1.5e-06 | 14.1 | Pfam-A | 107-179 (233) | alignment | ||
Range on Protein: 84-161
Range on HMM: 107-179/233.0
VSQLLQTDLSEFRKLPREEEEEEEdddEEEKAPVTLLDAQSLAQSFFNRLWEVAGQWQKQVPLAARasQRQWLVSIHA
||. ...| ....| .||| ..| ... | .| . ..| || ..| |.. .|.|. | ...||... |
vsppktedeekwkkfcleeelase...dktgfpplLtivsklnqsdvsslleylvkwekeeglese..lgrWlyalla
|
|||||||||
CaMBD | Calmodulin binding domain | 147-170 | 9.8e-06 | 11.9 | Pfam-A | 36-59 (77) | alignment | ||
Range on Protein: 147-170
Range on HMM: 36-59/77.0
AARASQRQWLVSIHAIRNTRRKME
..| ||. | .||..|... ..
rlrkhQRklLkaihkfRkvklelr
|
|||||||||
subfamily_PPM1A_pd | Subfamily PPM1A | 149-413 | 4e-58 | 190.0 | In-house | 6-280 (282) | alignment | ||
Range on Protein: 149-413
Range on HMM: 6-280/282.0
RASQRQWLVSIHAIRNTRRKMEDRHVSLPSFNQLfglsdpVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPEL---------PTDPEGALREAFRRTD
.|.... ... . .. |..|||.|. |...| . ..|||||||.| ..|.|.. |...| .. || . . |||..| ..|
qaegnglrygvssmqgwrvemEDahtvvaslgal......kdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLald
QMFLRKAKRER--LQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVShmdCWRVNGTLAVSRAIGDVFQKP--
. .. .. . ..||.| |..|. ..| .| |||| .|...|... | | |.|.|..|| |||. ||.| ||||.||||||.|| . |
eairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeee
-------YVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQqGSGLRVAEELVAAARERGSHDNITVMVVFL
||.|.. .| . ..|.|.||||| .||. .||| ||...|... .||..|| | |.||.||..|.||..
ekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrleva.deleevakalvdkalekgsrDNlsvlvvlf
|
|||||||||
0034914 | PP2C-like | 151-416 | 1e-71 | 234.0 | In-house | 17-293 (295) | alignment | ||
Range on Protein: 151-416
Range on HMM: 17-293/295.0
SQRQWLVSIHAIRNTRRKMEDRHVSLPSFNQLFGlsdpvNRAYFAVFDGHGGVDAARYAAVHVHTNAAR--------QPELPTDPEGALREAFRRTDQMF
. .. |... ... |...||... ..... |.. . ..|.||||||| .||..|. ..... .. .. ..|.| |||.|| ..|. .
lllllrvgvasdqGrrksneDavlvvlnllslle.....dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeel
LRKAKR--ERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHmdcWRVNGTLAVSRAIGDVFQK------
|..| . |.. |||| |.||| | .|.||..|||...|. .|..| | . |.| ...|..||...||.||| .||||.|||.||.||...|
lelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlklllsll
---PYVSGEADAASRALT-GSEDYLLLACDGFFDVVPHQEVVGLVQSHLTrQQGSGLRVAEELVAAARERGSHDNITVMVVFLRDP
|.|| | | .. || .. |.||||.||..||....|.| .|.|.|. .. . .||||| .| .|||.|||||.||.|...
lleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAlargsrDNiTvvvvrlngl
|
|||||||||
PP2Cc_SM00332 | 151-411 | 7.4e-70 | 228.4 | In-house | 6-274 (274) | alignment | |||
Range on Protein: 151-411
Range on HMM: 6-274/274.0
SQRQWLVSIHAIRNTRRKMEDRHVSLPSFNqlfglsDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTD-----PEGALREAFRRTDQMFLRK
|. .. . .. . |..|||.||. .... . ..|.||||||| ..|.... ... . ..... .| .| ||..||..||. .| .
snlglsygkssmqgwrksmeDahvvvvdlv......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeilee
AKRERL---QSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMdcwRVNGTLAVSRAIGDVFQK-------P
.....| ||.| |.||... .|.||..|||...|...|..| | . |.||..||..||.. ||.|. ||||.||||||.||.| | |
eqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkep
YVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQ-QGSGLRVAEELVAAARER-GSHDNITVMVV
|.. | | .|| ... |.||.|| .||. .||||..|...|... . .. ..||.|...|..| ||.|||||.||
yitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
|
|||||||||
subfamily_PPM1G2_pd | Subfamily PPM1G2 | 152-413 | 2.7e-49 | 160.6 | In-house | 16-286 (287) | alignment | ||
Range on Protein: 152-413
Range on HMM: 16-286/287.0
QRQWLVSIHAIRNTRRKMEDRHVSLPSfnqLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTD-PEGALREAFRRTDQMFLRKAKRER
... |. |.. |..||| |. . |. .|| . |.||||||||| ..|.||. ... |..... . | .|..|| .||. .|.. | .
naltkvgssamqGyrlnmeDahilene...lleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkd
LQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMdcwRVNGTLAVSRAIGDV-FQKPY--------VSGEA
..|.| | .|| | || |||. .| ..|.| .| |.|....|| ||.| ||||. ||||.||.|||.|| |.| | .
esaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfveln...rvngnLalsralgDfefkknvkkkpeeqivtavP
DAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQgSGLRVAEELVAAARERGSH------DNITVMVVFL
| . |. ....|.||||| .||. .||| ||...|.... . ...|||. . . |. ||.||..| |
DvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsga.kldeiieelldkclapdssntgvGcDnmtvvivvl
|
|||||||||
subfamily_PPM1E_pd | Subfamily PPM1E | 153-416 | 7.2e-127 | 415.0 | In-house | 2-264 (265) | alignment | ||
Range on Protein: 153-416
Range on HMM: 2-264/265.0
RQWLVSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDPEGALREAFRRTDQMFLRKAKRERLQ
... |||.|..|.|||||||||.|...|.||.|.| .||.||||||||||.||.|||.|.|....||..|..||. ||.|||..||..||.||.||.|.
seyevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklk
SGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQKPYVSGEADAASRALTGSE
||.|.|..||....|.||||||||..||..|..|.||.||.|||.|||.|||..||.| ....|||||.|.|||||||| .|||||||||.|. .|.|||
sGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgse
DYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLRVAEELVAAARERGSHDNITVMVVFLrDP
.||.|||||..|||...||| ||...|...... .||..||.||.|.||.|||||.|||| ||
eylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl.dp
|
|||||||||
subfamily_PPM1G_pd | Subfamily PPM1G | 154-245 | 3.6e-07 | 22.6 | In-house | 18-102 (473) | alignment | ||
Range on Protein: 154-245
Range on HMM: 18-102/473.0
QWLVSIHAIRNTRRKMEDRHVSLPSFNQlfglsdpvNRAYFAVFDGHGGVDAARYAAVHVHTN-AARQPELPTDPEGALREAFRRTDQMFLRK
. ... | | ..|| | ... ... . . |||.||||| . |.| | .. |.. | | ||.||| |. .
elsygasamqGwrvsqEDahncitdlde........dtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklkae
|
|||||||||
subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 156-413 | 8.7e-49 | 159.1 | In-house | 7-253 (255) | alignment | ||
Range on Protein: 156-413
Range on HMM: 7-253/255.0
LVSIHAIRNTRRKMEDRHVSLPSFNqlfglsDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPEL-PTDPEGALREAFRRTDQMFlrkAKRErLQSG
|. . | |||. | ||. | . |.|.|||||| .||..|. ... | .| ...|. .|..|.. .. .. ..| |
kvgfsdmiGrrptmedelviyGsfr......dksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi...serp.kfiG
TTGVCALIAGATLHVAWLGDSQVILV-QQGQVVKLMEPHRPERQDEKARIEALGGFVSHM-DCWRVNGTLAVSRAIGDVFQKPYVSGEADAA-SRALTGS
|| . .|| . .| .|||.|.| ..| ..| |.| ..|. ||..|||.| |||||||||||.||.| .|.| . | | . .
ttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskk
EDYLLLACDGFFDVVPHQEVVGLVQSHLTRQqgsglRVAEELVAAARERGSHDNITVMVVFL
. .|.||||| .|.. .| | .| . . . ||.| | ..|| |||.|.|. |
dkflilacdGiwdlisdeeaveivagisdpe.....kaaeklrdlayssGstdnisvivikl
|
|||||||||
subfamily_PPM1L_pd | Subfamily PPM1L | 156-414 | 6.8e-41 | 133.3 | In-house | 6-267 (269) | alignment | ||
Range on Protein: 156-414
Range on HMM: 6-267/269.0
LVSIHAIRNTRRKMEDRhvslpsFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHV------HT---NAARQPELPTDPEGALREAFRRTDQMFLRKA
|...... | .|||| |. .... .. .||||||||| || .| . . .|... ..| . . | . |. .| ||
qvavysvlGrrprmedr......feieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdeklleka
KRERLQSGTTGVCALIAGATLHVAWLGDSQVILV-QQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVF--QKPYVSGEADA
||. .||| . ||... | || .|||. .|. ..|. . | |.|.. |. ||. |||.. .|||.| ||.|||.|| .| | . |
kraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdi
ASRALTGS-EDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSglrvAEELVAAARERGSHDNITVMVVFLR
. | ..|.||.||..| .| | .. .| . | || . ||| |||||.|| |.
ltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfG....akslvlesfkrGsvdnitvlvvklk
|
|||||||||
PPM_PTC7 | 158-406 | 7.8e-76 | 247.9 | In-house | 4-259 (259) | alignment | |||
Range on Protein: 158-406
Range on HMM: 4-259/259.0
SIHAIRNTRRKMEDRHVSLPSFNQLfglSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTD--PEGALREAFRR--TDQMFLRKAKR-ERLQ
. .|... |..|||.|..|. ... |. ..|.||||||||| ||.||. |... .......... .| |||..|.. ||... ..... | ..
gasafqgfrksmedahialanless...sgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepst
SGTTGVCALIAGATLHVAWLGDSQVILVQQGQVV-KLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQKP------YVSGEADAAS
||.| |.||| | .|.||..|||...|...|..| .| | |.|...||..|||..||.||.....||||.||||||.||...|| .|| | | |
sGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdiss
RALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQqgSGLRVAEELVAAARERGSHDNI
.... ....|.||.||..|||..||.| ||.|.| . . ..||.|| | .|||.|||
tkideedefliLasdGlwdvvsdqeavdlvrselskk..dpmeaaeklvdeaiargsedni
|
|||||||||
PP2C | Protein phosphatase 2C | 158-406 | 1.1e-75 | 247.6 | Pfam-A | 4-255 (255) | alignment | ||
Range on Protein: 158-406
Range on HMM: 4-255/255.0
SIHAIRNTRRKMEDRHVSLPSFNQLfglSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTD--PEGALREAFRR-TDQMFLRKAKR-ERLQS
. ..... |..|||.|..|..... |. ..|.||||||||| .||.||. |... ...|...... | |||..|.. ||... ..... | ..|
gaselqgarksmedahialknleks...sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsks
GTTGVCALIAGATLHVAWLGDSQVILVQQGQVV-KLMEPHRPERQDEKARIEALGGFVSHmdCWRVNGTLAVSRAIGDVFQKP----YVSGEADAASRAL
|.| |.||| | .|.||..|||...|..... . .|.| |.|...||..|||..||.||. ..||||.||||||.||...|| .|| | | |. |
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvkl
TGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQgSGLRVAEELVAAARERGSHDNI
| ....|.||.||..||...||.| ||.|.|. .. | ..||||| | .|||.|||
teedefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni
|
|||||||||
PP2C | Protein phosphatase 2C | 158-406 | 1.1e-75 | 247.6 | In-house | 4-255 (255) | alignment | ||
Range on Protein: 158-406
Range on HMM: 4-255/255.0
SIHAIRNTRRKMEDRHVSLPSFNQLfglSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTD--PEGALREAFRR-TDQMFLRKAKR-ERLQS
. ..... |..|||.|..|..... |. ..|.||||||||| .||.||. |... ...|...... | |||..|.. ||... ..... | ..|
gaselqgarksmedahialknleks...sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsks
GTTGVCALIAGATLHVAWLGDSQVILVQQGQVV-KLMEPHRPERQDEKARIEALGGFVSHmdCWRVNGTLAVSRAIGDVFQKP----YVSGEADAASRAL
|.| |.||| | .|.||..|||...|..... . .|.| |.|...||..|||..||.||. ..||||.||||||.||...|| .|| | | |. |
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvkl
TGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQgSGLRVAEELVAAARERGSHDNI
| ....|.||.||..||...||.| ||.|.|. .. | ..||||| | .|||.|||
teedefliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni
|
|||||||||
PPM_PTC7_SpoIIE | 158-404 | 7.9e-41 | 133.3 | In-house | 4-220 (230) | alignment | |||
Range on Protein: 158-404
Range on HMM: 4-220/230.0
SIHAIRNTRRKMEDRHVSLPSFNQLfglSDPVNRAYFAVFDGHGGVDaaRYAAVHVHTNAARQPELPTD-PEGALREAFRRT--DQMFLrkakreRLQSG
. .|... |..|||.|.|.. ... |. .......||||| .|. ...| ... .. || .||..... | .||
gasaaqgarksmedahispanseks...sggrlalvvgdvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlalaadlede......psssg
TTGVCALIAGAT--LHVAWLGDSQVILVQQ-GQvvklmephrperqdEKARIeALGGFVS-HMDCWRVNGTLAVSRAIGDVFQKP---YVSGEADaASRA
.| |.||| . | |.||..||| ..||.. |. |. || ..||..| .. .||.|.||||.|.||.. .. .|. |.| |.
aTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.tsdg
LTGS-EDYLLLACDGFFDVVPHQEVVGLVQSHLTRQqgsglrvaeelvaaARERGSHD
.. . ...| ||.||..||.. ||.| ||...| . | |.. .|
elfgkdeflilasdglwdvlspqelvdlvrdelekp..............aaeglleD
|
|||||||||
subfamily_ILKAP_pd | Subfamily ILKAP | 158-412 | 4e-39 | 127.5 | In-house | 7-291 (293) | alignment | ||
Range on Protein: 158-412
Range on HMM: 7-291/293.0
SIHAIRN-TRRKMEDRHVSLPSFNQLFGLSD-PVNR-AYFAVFDGHGGVDAARYAAVHVHTNAARQ-P--ELPT---DPEGALREAFRRTDQMFLRKAKR
...| |. | .|.| || | .... .|.. .|.| .|.||||||.| |...|| ..| . .. | .. . . .| ..|..||. ||..|..
gayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklask
ER--LQSGTTGVCALIAGATLHVAWLGDSQVILVQQ---GQ---VVKLMEPHRPERQDEKARIEALGGFVSHMdcwRVNGTLAVSRAIGDV-FQKPYVSG
.. . |.| .. |. .|.|| ||||. .||.. |. .|.| | | ...|. ||. ||.| . ||.| | |||.||| |.. |.
akPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg...rvlGvlevsrsiGdgrfkrlGvis
EADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQ------QGSG--------LR-VAEELVAAARERGSHDNITVMVVF
| || . ...|||||...|. .||| ... | . ... .. ... | . | .||| ||.||..|
tPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvk
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 158-414 | 4.3e-31 | 101.1 | In-house | 5-308 (309) | alignment | ||
Range on Protein: 158-414
Range on HMM: 5-308/309.0
SIHAIRNTRRKMEDRHVSLPSFNQLFGlsdPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDPE----GALREAFRRTDQMFLR-------KA
. .| . |. |||. . . .. ... |..|||||||| .||..| |. .. .| .. .... |.|||| | . . ..
tseadqGgrkymeDvvaivleeeesae...elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktk
KRERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQ------VVKLMEPHRPERQDEKARIEALGGFVSHM-----DCWRV-----NGT--------L
. . .||| . .| . |.|| |||...| .. . .|.. |.|| .|| ||| ||| |... .|. || |
sgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFL
AVSRAIGDVF-----QKPY-VSGEADAASRALTGSED-YLLLACDGFFDVVPHQEVVGLVQSHLTRQQG---SGLRVAEELVAAARERGSH-----DNIT
||.|..||.. .. . || | | | |...|. ...|| ||...|.. ...| .|... . .. .. ||. || | .| .. ||..
avaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvs
VMVVFLR
|.||.|.
vivvile
|
|||||||||
0049733 | PP2C-like | 162-414 | 3.7e-54 | 176.4 | In-house | 11-234 (235) | alignment | ||
Range on Protein: 162-414
Range on HMM: 11-234/235.0
IRNTRRKMEDRHVSlpsfnqlfglsdpvNRAYFAVFDGHGGVDAARYAAVHVHTNAAR--QPELPTDPEGALREAFRRTDQMFLRKAKR--ERLQSGTTG
| . |. .||... ....|||.||||| |...|. ..... .. .. |..|.| |||.||.......|..|.. |. .|||
igrvrkvneDavlv..............glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTa
VCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVshmdcwRVNGTLAVSRAIGDVFQKpyvsgeADAASRALTGSEdYLLL
|.||. | .|.||..||| ..|...|..| | |.|.| ...|..||...||.| ||.| ||..||.|| . | .| . |. . .|||
vvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk......pdvtvlelepgd.flll
ACDGFFDVVPHQEVVGLVQShltrqqGSGLRVAEELVAAARERGSHDNITVMVVFLR
|.||..||....|.|.|..| . .||.|| .|..||..|||||.||.|.
asDGlwdvlsdeeivdllrs......ldleeaaerlvelalarggrDNiTvvvvrld
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 163-219 | 4.5e-06 | 18.6 | In-house | 9-61 (492) | alignment | ||
Range on Protein: 163-219
Range on HMM: 9-61/492.0
RNTRRK--MEDRHVslpsFNQLFGlsDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAAR
.|.| | |||... . . || . ||...|...||. | ||. || ..|. ..
knsrWKskmeDkrt....lqdyfg..ndvnscFfgiyDGynGataAeiaakelhevlle
|
|||||||||
subfamily_KAPP-like_pd | Subfamily KAPP-like | 167-412 | 1.9e-20 | 66.0 | In-house | 10-265 (266) | alignment | ||
Range on Protein: 167-412
Range on HMM: 10-265/266.0
RKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPEL-----PTDPEGALREAFRRTDQMFLRKAKRERLqSGTTGVCAL
.||| ... . . ||. | | ||||||| | || | . . .. . |. .. .. . . | | |.| ||
temedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfey.eGatatlal
IAG----ATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCwRVNGtLAVSRAIGDVFQKPYV---SGEADAASR-ALTGSED
. | || .||| .| . . ..| |. . ..|| || | .|. . |.|| ||||||.|| | | ..| ..| .|| ..
vwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqt.rinG.lavsralGdhfikelniGlisepyvsnrilltpfdk
YLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGlRVAEEL-VAAARERGSHDNITVMVVF
.|..| ||..||. .. . |.| .|. . ..|. | .| . ..||..|.||
flivasdGlwdvisGkdaiekvkslydqqated.kmasslletaiqsikakdnvsvivvk
|
|||||||||
PP2C_SIG_SM00331 | 185-412 | 1.9e-19 | 63.1 | In-house | 24-216 (217) | alignment | |||
Range on Protein: 185-412
Range on HMM: 24-216/217.0
LSDPVNRAYFAVFDGHG-GVDAARYAAVHVHTNAARQPELptdpeGALREAFRRTDQMFLRKakRERLQSGTTGVCALI--AGATLHVAWLGDSQVILVQ
.... | ..|.||.| |..|| ... .. | .| .|..|... . .. | ....| ..||. ....|..| .||| ..|..
vklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.....eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllr
QGQVVKLMEPhrperqdekariealggfvsH-----------MdcwrvngtlavsraigdvfqkpyvsgeadAASRALTGS-EDYLLLACDGFFDVVPH-
.|. |. . . . .| |. . .| |||. || .... .
dgklveilkd....................vegaplGlepevs.............................vdirelelekgdllllytDGltearsek
----QEVVGLVQSHLTRQQGSGLR-VAEELVAAARERGSHDNITVMVVF
... ........ . |||...|.... .|.|||.||.
gfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvvk
|
|||||||||
PP2C_2 | Protein phosphatase 2C | 188-302 | 8.8e-08 | 24.7 | Pfam-A | 21-147 (212) | alignment | ||
Range on Protein: 188-302
Range on HMM: 21-147/212.0
PVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPE-LPTDPEGA-LREAFRRTDQMFL--------RKA-KRERLQSGTTGVCALIAGATLHVAWLGDSQ
.. ..|| ||.| .. .| . ..|... | | .. . . ....|.. . | ..| . | . .|| ..|.|.. .. ....||.
asdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDga
VILV-QQGQVVKLMEPHRPERQDEKAR
.... ..|.| | ||. | . | .
ivvrdrdgevqllgepdsgeyanettf
|
|||||||||
PP2C_2 | Protein phosphatase 2C | 188-302 | 8.8e-08 | 24.7 | In-house | 21-147 (212) | alignment | ||
Range on Protein: 188-302
Range on HMM: 21-147/212.0
PVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPE-LPTDPEGA-LREAFRRTDQMFL--------RKA-KRERLQSGTTGVCALIAGATLHVAWLGDSQ
.. ..|| ||.| .. .| . ..|... | | .. . . ....|.. . | ..| . | . .|| ..|.|.. .. ....||.
asdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDga
VILV-QQGQVVKLMEPHRPERQDEKAR
.... ..|.| | ||. | . | .
ivvrdrdgevqllgepdsgeyanettf
|
|||||||||
subfamily_PPM1K_pd | Subfamily PPM1K | 191-414 | 1.5e-36 | 118.9 | In-house | 31-259 (263) | alignment | ||
Range on Protein: 191-414
Range on HMM: 31-259/263.0
RAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDPEGALREAFRRTDQMFLRKAK-----RERLQSGTTGVCALI-AGATLHVAWLGDSQVILVQQGQ
|.||||||.|. || .. .... | | | | |..|| |. . | .. .| |.|||| .|. | | .| ||||. || ..|.
llyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGk
VVKLMEPHRPERQDEKARIEALGGFVSH--MDCWRVNGTLAVSRAIGDVFQKPY-VSGEADAASRAL-TGSEDYLLLACDGFFDVVPHQEVVGLVQSHLT
|| . | ||...|| || | ||.|. .. .||| ||..|..||. |.| | . .. | . ... .|.| || .|| ||. ||.
akkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlchd
RQQgsglrVAEELVAAARERGSHDNITVMVVFLR
.. |. |. .| . ||.|| |..|| |.
pee.....aahalteqalqygsednatavvvplg
|
|||||||||
subfamily_Choan-PPM1K-like_pd | Subfamily Choan-PPM1K-like | 194-331 | 3.8e-17 | 55.8 | In-house | 24-183 (292) | alignment | ||
Range on Protein: 194-331
Range on HMM: 24-183/292.0
FAVFDGHG--GVDAARYAAVHVHTNAA-RQPELPTDPEGALREAFrRTDQMFLRKAKRERLQSGTTGVCALIAGA-TLHVAWLGDSQVILVQ-----QGQ
||.|||| | | .|. .. . ..| .| | . . . .|....|. ||| . | .| .|||...| . . .
aavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllril.diaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsdye
VVKLMEPHRPERQDEKARIEALGGFVS--HM------DCWRV------NGTLAVSRAIGDV
.. | |.|| ||.||| . ||.| .. || .| ||.|||.||.
liPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdf
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 229-306 | 8.1e-10 | 31.0 | In-house | 138-213 (404) | alignment | ||
Range on Protein: 229-306
Range on HMM: 138-213/404.0
GALREAFRRTDQMFLRKAKRERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERqdEKARIEAL
||| .|| . |.. | .. |.. | | . ||. |.|| |||. |||.......| . . || |. |. |
GalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPet..eRqRlqel
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 233-331 | 2e-06 | 20.2 | In-house | 133-238 (398) | alignment | ||
Range on Protein: 233-331
Range on HMM: 133-238/398.0
EAFRRTDQMFLRKaKRERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQ---G--QVVKLMEPHRPERQDEKARIEALGGFVSH---MDCWRVNGTLAV
||...... ||. . . ||.. ..||| | .|||| ||.. .| .| | ..||| . . . ..| ||.. . . |. |.|.
ealkklkekslre.allvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqP
SRAIGDV
.|| |||
lRAFGdv
|
|||||||||
subfamily_TAB1_pd | Subfamily TAB1 | 249-334 | 1.3e-10 | 33.7 | In-house | 125-213 (333) | alignment | ||
Range on Protein: 249-334
Range on HMM: 125-213/333.0
ERLQSGTTGVCALIAGATLHVAWLGDSQVILVQ---QGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQK
| .. ||| | ||| |.|| |||. .||. . .|..| | . .|| |.. || . .. .. | |.||| |
eeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvk
|
|||||||||
subfamily_PPM1G_pd | Subfamily PPM1G | 251-414 | 1.5e-28 | 93.0 | In-house | 294-471 (473) | alignment | ||
Range on Protein: 251-414
Range on HMM: 294-471/473.0
LQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVShMDCwRVNGTLAVSRAIGDVFQKP---------YVSGEA
.|||| | ||. . .| || ||| .| ..|. . | . |.|| . |..|||. || | .| |||| | .|||.|| . | .|
edsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvd.edg.RvnGGLnlsRAlGDhaYkkneeLplkeqmisAlP
DAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGS-GLRVAEELVAAA-----RERGS-HDNITVMVVFLR
| ..|| ...| ||||| ..|. |||| |...|. .. | .. |||. |. |. || ||..| |.
DikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllk
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 260-383 | 2.2e-15 | 49.3 | In-house | 183-310 (492) | alignment | ||
Range on Protein: 260-383
Range on HMM: 183-310/492.0
ALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFV-SHMDCWRVNGTLAVSRAI---GDVFQKPYVSGEADAASRALTGSEDYL
|. ..|..| |. | .|...|. ..| | |. . |. |.| |. | . . .||| | . | . || | | | | |. .|
hleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqfl
LLACDGFFDVVPHQEVVGLVQSHLTRQQ
.|| | ..|. ..||. ||.. |. .
vlAsnGlWevlseeevlsLvkqtlaiyk
|
|||||||||
subfamily_PHLPP_pd | Subfamily PHLPP | 266-413 | 1.1e-11 | 37.1 | In-house | 106-245 (246) | alignment | ||
Range on Protein: 266-413
Range on HMM: 106-245/246.0
TLHVAWLGDSQVILVQQGQVVKLMEPHRPERQdEKARIEALGGFVSHMDcwRVNGTLAVSRAIGDVFQKPYVSGEADAASRALTGSEDYLLLACDGFFDV
.|.|| | | .|. .|. ..| ... |.. | || .... . ..|| .. .| .| .| |.| . . || ...|.. . ...|
sLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitedn..kingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWev
VPHQEVVGLVqshltRQQGSGLRVAEELVAAARERGSHDNITVMVVFL
. .|.| | |.. . | .| || | | .|...|.|| |
lsideaveav.....rkeedplvaAkklvdlaqsygaadsvsvlvvrl
|
|||||||||
subfamily_Dicty-PPM-1_pd | Subfamily Dicty-PPM-1 | 267-412 | 2.3e-15 | 49.2 | In-house | 128-275 (276) | alignment | ||
Range on Protein: 267-412
Range on HMM: 128-275/276.0
LHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCwRVNGtLAVSRAIGDVFQKPYV---SGEADAASR-ALTGSEDYLLLACDGF
| || .||| .| . . ..| |. . .|| || | .|. . |.|| ||||||.|| | | ..| ..| .|| ...|..| ||.
lqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqt.rinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGl
FDVVPHQEVVGLVQSHLTRQQGSGlRVAEEL-VAAARERGSHDNITVMVVF
.||. .. . |.| .|. . ..|. | .| . ..||..|.||
wdvisGkdaiekvkslydqqated.kmasslletaiqsikakdnvsvivvk
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 296-414 | 7.3e-14 | 44.3 | In-house | 179-304 (305) | alignment | ||
Range on Protein: 296-414
Range on HMM: 179-304/305.0
RQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQKPYVSGEADAASRALTGSED-YLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSG------LR
..... ||| |.. . .. .||. | .|| .|| | .| . | .. ..| .|.|| || .|. .|.||. |. | .. ..
ldeiririeslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfne
VAEELVAAARERGSHDNITVMVVFLR
. . | | .||| ||||.....|.
isrviveeavkrgsgDnitlviiklk
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 333-384 | 1.2e-08 | 27.5 | In-house | 266-317 (398) | alignment | ||
Range on Protein: 333-384
Range on HMM: 266-317/398.0
QKPYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQG
||.. | . |. |. .. .|.|| || .|.. ..||| ||. ||....
tPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkke
|
|||||||||
PPM_PTC7_SpoIIE_motif | 352-411 | 2.2e-08 | 27.7 | In-house | 12-78 (81) | alignment | |||
Range on Protein: 352-411
Range on HMM: 12-78/81.0
EDYLLLACDGFF-------DVVPHQEVVGLVQSHltrQQGSGLRVAEELVAAARERG---SHDNITVMVV
| |||..|| . .... .|.. |.... ...| ..|..||....|.| ..|.||..|.
gdvllLyTDGltEardsdgelfgkeellrladra...egkslqeladklvdevlengsgereDDitllvl
|
|||||||||
PPM_PTC7_motif | 356-406 | 8.9e-18 | 57.5 | In-house | 1-51 (51) | alignment | |||
Range on Protein: 356-406
Range on HMM: 1-51/51.0
LLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLRVAEELVAAARERGSHDNI
.||.||..||...||.|.||...|. . .|. ..||.|| |..|||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
|