Gene PPM1G in Homo sapiens

Synonym: PP2CG, PP2CGAMMA, PPP2CG, PPM1G

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1G
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP180_AA protein Get Run
HsapP180_AA_20-507 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 4-507 6.4e-210 691.1 In-house 1-472 (473) alignment 
Range on Protein: 4-507
Range on HMM: 1-472/473.0
YLSQPNTVKCSGDGVgapRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDA
|||.|.. | | |.    .  | ||.|||||||||.|||||||..||..|..|.|||||||.||| |.||.|||..|.||.||||...||||.||||.|.
ylskpkvekesedes...neelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDe

KLTTEEVIKELAQIAGrPTEDEDEKekvADEDDVDNEEAALLHEEATMTIEELLTRYgqnchkgpphskSGGGTGEEPGSQGLNGEAGPEDSTRETPSQE
||..||..|||..||. ..|||||.   ...|. |..|..||.|||.....|||.|.            .| |...|  || |. .|  ||...|....|
klkaeeslkelkeiae.aeededee...eeddeededeiellteeaeipldellkrl............dgdgsekeelsqallegaasedeedededee

NGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLprvakskffEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEE
. ...|.....|...|. ..|.. |.. . .... ........|          |..|||..|.|||||..|...||||....||.|.||||.|.||.||
eeeeekdteeeskeeekkakaakegkqekkeedesekeeeeeeke.........eeeedekgeteeeeeededeeeeedeeeaeeeeeeedeedeeeeee

DDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDH
|.|.||......|.|.|||||.||||||||||...|.||||||||||||.|..|||||.|.||||||||||.||..|||||..|||||||||||||.|||
dgegeeakeeldgseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDh

FYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENgelrLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIII
.||.|..||..||||||||||||||||...||.|.|||||||||.|||||||...|.....|.     ||.|||||||.|||||||||||||||||.||.
aYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees....vlseiveeLlDaclapdtsgDGtGCDnmtviiv

CFKP
..|.
llkk
0034914 PP2C-like 21-507 9.2e-76 247.3 In-house 17-292 (295) alignment 
Range on Protein: 21-507
Range on HMM: 17-292/295.0
PRLPLPYGFSAMQGWRVSMEDAHNCIPEL---DSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQ-------KAYKEGKLQKALEDAFLAIDAKLTTEEV
  | | .|.. .||.| |.|||. ....|   ......| |.||||| ..| .....|.......         . .  ...||..||||.| .| .. .
lllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelal

IKelaqiagrptededekekvadeddvdneeaallheeatmtieelltrygqnchkgpphsksgggtgeepgsqglngeagpedstretpsqengptaka
 .                                                                                                  
lr..................................................................................................

ytgfssnsergteagqvgepgiptgeagpscssasdklprvakskffedsedesdeaeeeeedseecseeedgysseeaeneededdteeaeeddeeeee
                                                                                                    
....................................................................................................

emmvpgmegkeEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMdGRVNGGLNLSRAIGDHFYKRNKN
              . ||||||||||||..|.|||.||||.|..  |... ...|||| .| | .||..||| |.. |||||.|...||.||...|....
...........pelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlkllls

LPPEEQMISALPDIKVLTLT-DDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDEngelrlLSSIVEELLDQCLApdtsgdGTGCDNMTCIIICFKP
|...|...|| ||..||.|| .|..|...|.||.|.|.|..|.||...| ......      |. ..|||.|..||      . ..||.|........
lllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld......leeaaeeLvdlAla......rgsrDNiTvvvvrlng
PP2Cc_SM00332 22-503 1.4e-98 322.6 In-house 7-274 (274) alignment 
Range on Protein: 22-503
Range on HMM: 7-274/274.0
RLPLPYGFSAMQGWRVSMEDAHNCIPELD--SETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEG----KLQKALEDAFLAIDAKLTTEEVIKELA
.| |.||.|.|||||.||||||.....|.  .....|.|.|||||.||| ...|.||...|... .|..    . ..||..|||..| ....||  ||| 
nlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskele

Qiagrptededekekvadeddvdneeaallheeatmtieelltrygqnchkgpphsksgggtgeepgsqglngeagpedstretpsqengptakaytgfs
.                                                                                                   
n...................................................................................................

snsergteagqvgepgiptgeagpscssasdklprvakskffedsedesdeaeeeeedseecseeedgysseeaeneededdteeaeeddeeeeeemmvp
                                                                                                    
....................................................................................................

gmegkeepgSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGkVTMDGRVNGGLNLSRAIGDHFYKRNKnlPPEE
         ..||.||||||.....|.|||.||||.|....|||...|.|||||||.|..|||.||| |...|||||||..|||.||||.|.||  ...|
.........alsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg.vvekgrvngglavsrafGdhflkknk..klke

QMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRdengeLRLLSSIVEELLDQCLAPDtsgdGTGCDNMTCIII
..|.|.||.||.|||...||...|.||.|.|.|.|||||.........      .   . ..||||......    |...||.|....
pyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg.....ktndpqeaaelldeeairr....ggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 23-111 1.7e-20 66.6 In-house 10-108 (282) alignment 
Range on Protein: 23-111
Range on HMM: 10-108/282.0
LPLPYGFSAMQGWRVSMEDAHNCIPELDSE--TAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAY--------KEGKLQKALEDAFLAIDAKLTTEEVI
..| || |.||||||.|||||... .| .    ..|.|.|||.|.||| |..| |.. | .....        .. ....||...|||.| .. ...  
nglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstd
0049733 PP2C-like 25-108 2.5e-12 39.9 In-house 3-82 (235) alignment 
Range on Protein: 25-108
Range on HMM: 3-82/235.0
LPYGFSAMQGW-RVSMEDAHNCipeldsETAMFSVYDGHGGEEVALYCAKYLPDIIKDQ-KAYKEGKLQKALEDAFLAIDAKLTTE
| .|.. ..|. |  .|||. .      ....| |.||||| ... .....|....... ... . .|..||..||||... |  .
lsvgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallel
subfamily_PPM1G2_pd Subfamily PPM1G2 27-113 1.4e-26 86.1 In-house 21-112 (287) alignment 
Range on Protein: 27-113
Range on HMM: 21-112/287.0
YGFSAMQGWRVSMEDAHNCIPEL-----DSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKE
 | |||||.|..|||||   .||     |...|.|.|.|||||..|| |..| |  .|. .|..|||.|...|.||||..| .|. .| .|.
vgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkd
PPM_PTC7 27-107 2.9e-17 56.0 In-house 3-91 (259) alignment 
Range on Protein: 27-107
Range on HMM: 3-91/259.0
YGFSAMQGWRVSMEDAHNCIP-----ELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEG-KLQKALEDAFLA--IDAKLTT
.|.||.||.|.|||||| . .     . ... | |.|.||||| |.| |... |..|.| .|  .|. ||.||| ..|||  .| .|..
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelks
PP2C Protein phosphatase 2C 27-107 3.2e-17 55.9 Pfam-A 3-90 (255) alignment 
Range on Protein: 27-107
Range on HMM: 3-90/255.0
YGFSAMQGWRVSMEDAHNCIP-----ELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEG-KLQKALEDAFLA-IDAKLTT
.|.|..||.| |||||| ...     . .|. |.| |.|||||.|.| |... |..|.| ||  .|. |..||| ..||| .| .|..
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks
PP2C Protein phosphatase 2C 27-107 3.2e-17 55.9 In-house 3-90 (255) alignment 
Range on Protein: 27-107
Range on HMM: 3-90/255.0
YGFSAMQGWRVSMEDAHNCIP-----ELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEG-KLQKALEDAFLA-IDAKLTT
.|.|..||.| |||||| ...     . .|. |.| |.|||||.|.| |... |..|.| ||  .|. |..||| ..||| .| .|..
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks
PPM_PTC7_SpoIIE 27-108 2.6e-11 36.8 In-house 3-87 (230) alignment 
Range on Protein: 27-108
Range on HMM: 3-87/230.0
YGFSAMQGWRVSMEDAHNCIP-----ELDSETAMFSVYDGHGGEEvaLYCAKYLPDIIKDQKaYKEGK-LQKALEDAFLAIDAKLTTE
.|.||.||.| |||||| . .       ..  ... ..||||| .   .... | .... .. ....  . ..|....||..|.|..|
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede
subfamily_PPM1K_pd Subfamily PPM1K 28-107 1e-11 37.4 In-house 7-84 (263) alignment 
Range on Protein: 28-107
Range on HMM: 7-84/263.0
GFSAMQGWRVSMEDAhNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKaYKEGKLQKALEDAFLAIDAKLTT
|. ...| |   ||   .. ||| |   ..|.|||.|   | .. . |  |.|. .  || .|.. | .||. .| ||. 
GkdsliGkraenedr.iklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkr
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 28-107 2.1e-09 30.0 In-house 9-90 (255) alignment 
Range on Protein: 28-107
Range on HMM: 9-90/255.0
GFSAMQGWRVSMEDAHNCIPELD--SETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTT
||| | | | .|||      .    |.  .....|||||.. | .... |. |...    .. . .|.|..|. .|. ... 
gfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqise
subfamily_PPM1E_pd Subfamily PPM1E 30-108 5.4e-12 38.4 In-house 9-94 (265) alignment 
Range on Protein: 30-108
Range on HMM: 9-94/265.0
SAMQGWRVSMEDAHNCIPEL----D----SETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLqKALEDAFLAIDAKLTTE
 |... |  ||| | ....|    .    .|.|.|.|.||||| | | | |. |.  . .|.  ||  . .||..|| ..| .... 
aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqk
subfamily_ILKAP_pd Subfamily ILKAP 30-104 2.7e-07 23.0 In-house 10-99 (293) alignment 
Range on Protein: 30-104
Range on HMM: 10-99/293.0
SAMQGWRVSMEDAHNCIPELD----------SETAMFSVYDGHGGEEVALYCAKYLPDIIKDQK-----AYKEGKLQKALEDAFLAIDAK
.  .| |  |.|||  . .||          |  . ..|.|||.|.  . ..|. |   |...      . || ...|.| |.| . | .
aerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdee
subfamily_PPM1D_pd Subfamily PPM1D 31-106 1.1e-10 34.1 In-house 8-91 (309) alignment 
Range on Protein: 31-106
Range on HMM: 8-91/309.0
AMQGWRVSMEDAHNCIPEL-----DSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYK---EGKLQKALEDAFLAIDAKLT
| || |  |||      |      . | |...|.|||||.| | .  . |   ||.|| .    . ....|...||||.  .. 
adqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamk
subfamily_PPM1L_pd Subfamily PPM1L 31-119 4.6e-09 28.9 In-house 11-107 (269) alignment 
Range on Protein: 31-119
Range on HMM: 11-107/269.0
AMQGWRVSMEDAHNCIPELDSET--AMFSVYDGHGGEEVALYCAKYLPDIIKDQK----AYKEGKL----QKALEDAFLAIDAKLTTEevIKELAQIAG
...| |  |||  .   ... .|   .|.|.||||||  | .. . |.. ||..     | || ..    .| |.|  |..| || ..  .|   .|||
svlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllek..akraediaG
subfamily_PP2D1_pd Subfamily PP2D1 35-107 4.4e-06 18.7 In-house 13-86 (492) alignment 
Range on Protein: 35-107
Range on HMM: 13-86/492.0
WRVSMEDAHNCIPEL--DSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALeDAFLAIDAKLTT
|. .|||..    .   | ... |..|||. |   |  .|| |.... .. .  . ... .  .  |.....|| 
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervsltt.avnlidnndltd
subfamily_PPM1H_pd Subfamily PPM1H 244-372 9.1e-11 34.1 In-house 80-207 (404) alignment 
Range on Protein: 244-372
Range on HMM: 80-207/404.0
ASDKLPRVAKSKFFEDSEdESDEAEEEEEDSEECSEEEDGYSSEEAENEED---EDDTEEAEEDDEEEEEEMMVpgmEGKEEPGSDSGTTAVVALIRGKQ
|| .| .. |.|. .  |    | ..|||.  |.|..|. .| .|  .|..   |.    | |.   | .|..    . .|.     | ||.|||.  ..
askllhkhlkekledvle.llleksaeeeenteesskespssvseiyeekeiskeeLviGalesaflemDeqia...rereayrikGGCtalvalvllgk

LIVANAGDSRCVVSEAGKALDMSYDHKPEDEV
| |||||||| .... ..  ..| |. || | 
lYvanaGDsRailvrkdeiiplsadftPeteR
subfamily_PPM1A_pd Subfamily PPM1A 274-506 2.2e-59 194.1 In-house 85-281 (282) alignment 
Range on Protein: 274-506
Range on HMM: 85-281/282.0
SEECSEEEDGYSSEEAENEEDEDDTEEAEEDdeeeeeemmvpgmegkeepgsdsGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVE
.|  .. ..|. . . . .|...|...|..                        |.|||..|.. |.||.||.|||| |... |||  ...||||... |
devkealrqgfLaldeairelstdlktadks.......................GsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkE

LARIKNAGGKVTmDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELrlls
  ||..|||.|.  .|||| | .|||.||..||.......|||..|| |.....  .....|.|.|||||| |.|..|||......... ||  |.    
kkRieqAGGsvv.vsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev....

siVEELLDQCLAPDTSgdgtgcDNMTCIIICFK
  ...|.|..|  ..       ||.......|.
..akalvdkalekgsr......DNlsvlvvlfa
subfamily_PPM1E_pd Subfamily PPM1E 288-478 2.4e-37 121.5 In-house 66-245 (265) alignment 
Range on Protein: 288-478
Range on HMM: 66-245/265.0
EAENEEDEDDTEEAEEDDEEEEEEMMVPGmegKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD
....|....|..|| ..  .. .|...      |. .  ||.||||.||...|| ||  |||. .. . |.|. .   ||||.| | .||..||| | . 
lvrqeklkedpaealkeafkltDerflqk...aereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvi

G--RVNGGLNLSRAIGDHFYKrnknlppeeQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENgELRLLSSIVEE
|  |||| |..||||||  .|         ...|. .|.  ..|....|....||||.|.|.  .|||. ... ...  |. . ..  ..||.
gawRvnGvLsvsRaiGDvklk.........pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaed.lsevakllvea
PP2C_2 Protein phosphatase 2C 318-467 3.2e-06 19.6 Pfam-A 88-202 (212) alignment 
Range on Protein: 318-467
Range on HMM: 88-202/212.0
EGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCV-VSEAGKALDMSYDHKPEDEVELARIKNA--GGKVtmdgrvngglnlsraigdhfykrnknlppe
| ..|. .| .|| ..|.|......... ||...| ....|..  .. ... | . |. ... .  ....                              
eaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..............................

eqmisalpDIKVLTlTDDHEFMVIACDGIWNVMSSQE-VVDFIQSKISQRDENG
        .|. |. ... .  ..  ||... ....| . ....  ... .|.|
........rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletleeeg
PP2C_2 Protein phosphatase 2C 318-467 3.2e-06 19.6 In-house 88-202 (212) alignment 
Range on Protein: 318-467
Range on HMM: 88-202/212.0
EGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCV-VSEAGKALDMSYDHKPEDEVELARIKNA--GGKVtmdgrvngglnlsraigdhfykrnknlppe
| ..|. .| .|| ..|.|......... ||...| ....|..  .. ... | . |. ... .  ....                              
eaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..............................

eqmisalpDIKVLTlTDDHEFMVIACDGIWNVMSSQE-VVDFIQSKISQRDENG
        .|. |. ... .  ..  ||... ....| . ....  ... .|.|
........rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletleeeg
PP2C Protein phosphatase 2C 320-489 3.1e-59 193.6 Pfam-A 94-252 (255) alignment 
Range on Protein: 320-489
Range on HMM: 94-252/255.0
KEePGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKAL-DMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKnlppeEQMI
..   |.||.||||||||||.|.|||.||||.|.. ...|   ...||||.|| | .||..|||.|   ||||| |..|||.||...|...     ||..
nt.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlv

SALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDengelrLLSSIVEELLDQCLAPDTS
|| ||... .||...||...|.||.|.|.|.||.||...|..|. .       .. . |||.|...|. ..
saePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiargse
PP2C Protein phosphatase 2C 320-489 3.1e-59 193.6 In-house 94-252 (255) alignment 
Range on Protein: 320-489
Range on HMM: 94-252/255.0
KEePGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKAL-DMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKnlppeEQMI
..   |.||.||||||||||.|.|||.||||.|.. ...|   ...||||.|| | .||..|||.|   ||||| |..|||.||...|...     ||..
nt.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlv

SALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDengelrLLSSIVEELLDQCLAPDTS
|| ||... .||...||...|.||.|.|.|.||.||...|..|. .       .. . |||.|...|. ..
saePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiargse
subfamily_ILKAP_pd Subfamily ILKAP 320-467 2.2e-30 98.8 In-house 106-250 (293) alignment 
Range on Protein: 320-467
Range on HMM: 106-250/293.0
KEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVV---SEAGK---ALDMSYDHKPEDEVELARIKNAGGKVTmDGRVNGGLNLSRAIGDHFYKRNKnlpp
|..|    |.||.| |.  . | ||| |||..|.   .|.|.   .. .. ||.| .. |  ||. |||.|. ||||.| |. ||.|||  .||      
kakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr.dgrvlGvlevsrsiGdgrfkrlG....

eeqmISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENG
    ... ||.| ..||..  |.|.||||.|.|.| .|||.||.. . ..... 
....vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddr
PPM_PTC7_SpoIIE 320-463 2.6e-28 92.4 In-house 87-212 (230) alignment 
Range on Protein: 320-463
Range on HMM: 87-212/230.0
KeepGSDSGTTAVVALIRGKQ--LIVANAGDSRCVVSEA-GKaldmsydhkpedevELARIkNAGGKVT---MDGRVNGGLNLSRAIGDHFYKRnknlpp
.    |.||.|||||||.. .  | |||||||..... . |.              |  ||  ||| .    ..|||.| |..|.|.|| ...       
e...psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......

EEQMISALPDiKVLTLTDD-HEFMVIACDGIWNVMSSQEVVDFIQSKISQR
......| ||  . ..... .||...|.||.|.|.|.||.||.... ... 
tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp
PPM_PTC7 323-489 2.8e-58 190.4 In-house 97-256 (259) alignment 
Range on Protein: 323-489
Range on HMM: 97-256/259.0
PGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKAL-DMSYDHKPEDEVELARIKNAGGKVT--MDGRVNGGLNLSRAIGDHFYKRNKNlppEEQMIS
  |.||.|||||||.|..|.|||.||||.|..  |.|   ...||||..| | .||..|||.|    .||||| |..|||.||...|...    |||..|
epstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvs

ALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRdengelrLLSSIVEELLDQCLAPDTS
| |||.. ......||...|.||.|.|.|.||.||...| .|..        .. . |.|.| ..|....
aePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.......dpmeaaeklvdeaiargse
0049733 PP2C-like 323-506 5e-39 127.0 In-house 88-234 (235) alignment 
Range on Protein: 323-506
Range on HMM: 88-234/235.0
PGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVtmdgRVNGGLNLSRAIGDHFYKrnknlppeeqmisalP
. . .||||||||..|..|.|||.||||...   ||.. ...||.| .| | .||..||| |    ||.|.| |.||.||...|               |
elagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav....rvpgrlaltralGdlllk...............p

DIKVLTLTDDHeFMVIACDGIWNVMSSQEVVDFIQSkisqrdengelRLLSSIVEELLDQCLApdtsgdGTGCDNMTCIIICFK
|. ||.|.... |...|.||.|.|.|..|.||...|             |. ..|.|....||      . |.||.|.......
dvtvlelepgd.flllasDGlwdvlsdeeivdllrs...........ldleeaaerlvelala......rggrDNiTvvvvrld
PP2C_SIG_SM00331 323-503 2.1e-09 30.3 In-house 82-215 (217) alignment 
Range on Protein: 323-503
Range on HMM: 82-215/217.0
PGSDSGTTAVVALI--RGKQLIVANAGDSRCVVSEAGKAL-DMSYdhkpedevelariknaggkvtmdgrvngglNLSRAIG-----Dhfykrnknlppe
  .....|...||.  ....| .|||||||...   ||   . .                               ......|     .            
eekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd..............................vegaplGlepevs............

eqmisalPDIKVLTLTDdHEFMVIACDGIWNVMSSQE-----VVDFIQSKIsqrdeNGELRLLSS-IVEELLDQCLAPDTsgdgtgCDNMTCIII
       .||. |.|    ...... ||.....|...     . ......      . |.. |.. |||||| .  .. .       |..| ...
.......vdirelelek.gdllllytDGltearsekgfaeerleeiledlv.....dseaqelaqkiveellelakgsng......eDdiTvvvv
subfamily_PPM1G2_pd Subfamily PPM1G2 324-505 7.6e-69 224.8 In-house 112-286 (287) alignment 
Range on Protein: 324-505
Range on HMM: 112-286/287.0
GSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDgRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPD
 ...|.||||.||. ..|.||||||||.|.|..|..  .|.||||..| |  ||..||| | .. |||| | ||||.||. .|.|....||||.. |.||
desaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkknvkkkpeeqivtavPD

IKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDEngelrlLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICF
. |  |..|.||.|.||||||.|....||||......... .      |..|.|||||.|||||.|  | ||||||..|...
vlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgak......ldeiieelldkclapdssntgvGcDnmtvvivvl
subfamily_PDP_pd Subfamily PDP 324-469 4.5e-23 75.0 In-house 149-321 (398) alignment 
Range on Protein: 324-469
Range on HMM: 149-321/398.0
GSDSGTTAVVALIRGKQLIVANAGDSRCVVS---EAG--KALDMSYDHKPEDEVELARIKNAGG-----KVTMDGRVNGGLNLSRAIGDHFYKRNKNLPP
 . ||..|..|||.|..| |||.||.|.|.    | |  .|  .| |.  . | |. |||..        | ..||. | |  .|| ||  || ...|  
valsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqk

-------------EE----QMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGEL
             ..      ..| |..    |. .  |.|.| ||.|...|..|||. ..  .....|. ..
kvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv
subfamily_PPM1D_pd Subfamily PPM1D 324-387 1.1e-12 40.7 In-house 105-174 (309) alignment 
Range on Protein: 324-387
Range on HMM: 105-174/309.0
GSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGK------ALDMSYDHKPEDEVELARIKNAGGKVTMD
 | .|||| | .||...| ||. |||. |..   .      |  .  |||||.  |  ||...||.|.. 
lstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 325-464 1.3e-31 102.8 In-house 93-227 (255) alignment 
Range on Protein: 325-464
Range on HMM: 93-227/255.0
SDSGTTAVVALIRGKQLIVANAGDSRCVVS-EAGKALDMSYDHKPEDEVELARIKNAGGKVTMD---GRVNGGLNLSRAIGDHFYKrnknlpPeeqMISA
   ||||...|| ... ..|| |||| |..   | |  .|.|||| .| |  ||...||.|  .    |||| | .|||.|| | .      |    . .
kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle......P...fvvp

LPDIK-VLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSkISQRD
 ||..  |. . ...|...||||||...| .| |. . . ||. .
dPdlsqsleiskkdkflilacdGiwdlisdeeaveivag.isdpe
subfamily_PPM1K_pd Subfamily PPM1K 325-458 1.2e-26 86.4 In-house 96-227 (263) alignment 
Range on Protein: 325-458
Range on HMM: 96-227/263.0
SDSGTTAVVALIR-GKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD----GRVNGGLNLSRAIGDHFYKRNKnlppeeqmIS
  ||||| |.|.| |..|..|. |||| ..   |||  .. ||.|| | |  |||.|||.|...     .||| | ..|..||   ||          . 
lssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG........vi

ALPDIKVLTL-TDDHEFMVIACDGIWNVMSSQEVVDFIQS
| |. | | .  ..  |.|.  ||| .|..|||. |... 
atPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 325-404 3.1e-15 49.5 In-house 83-184 (292) alignment 
Range on Protein: 325-404
Range on HMM: 83-184/292.0
SDSGTTAVVALIRGK-QLIVANAGDSRCVVSE-----AGKALDMSYDHKPEDEVELARIKNAGGKVT----------MDGRV------NGGLNLSRAIGD
  ..|..| | .|   .||.|| ||||...         .   .| ||||||  | |||..|||.|.             ||      .|.| ||||.||
esattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGd

HF
  
fh
subfamily_PPM1L_pd Subfamily PPM1L 326-462 4.4e-32 104.4 In-house 105-238 (269) alignment 
Range on Protein: 326-462
Range on HMM: 105-238/269.0
DSGTTAVVALIRGKQLIVANAGDSRCVVS-EAGKALDMSYDHKPEDEVELARIKNAGGKVTMDG--RVNGGLNLSRAIGDHFYKrNKNlppeeqMISALP
 .||||..||.....||||| |||| |.  . |||. .|.||||..  |  |||.||| ....|  ||.| |  |||.||.  | .||      .. | |
iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.dkn......lviadp

DIKVLTLTDD-HEFMVIACDGIWNVMSSQEVVDFIQSKISQ
||  . | |   ||...|.||.|. .| .| | ||. ....
diltfdlddhkpeflilasdGlwdtfsneeavrfikerlke
subfamily_PP2D1_pd Subfamily PP2D1 326-463 5.8e-18 57.8 In-house 175-309 (492) alignment 
Range on Protein: 326-463
Range on HMM: 175-309/492.0
DSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKV---TMDGRVNGGLNLSRAIGDHfykRNKNLppeEQMISALP
..  .  | |.    | .||||. . |.  .|||  .  .| |... |  |...||. |      |.||| |.  | .| .    . .|   .. .   |
kesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny...GdpkL...kksvipeP

DIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQR
 ..  .|..   |.|.|  |.|.|.| .||.  ... . . 
kttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiy
Subfamily Dicty-PPM1L-like 326-402 1.2e-07 23.8 In-house 213-294 (305) alignment 
Range on Protein: 326-402
Range on HMM: 213-294/305.0
DSGTTAVVALIRGKQ-LIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDG----RVNGGLNLSRAIGD
| ... .|.    .. | ||.|.|.. |..  |..  .||....|.  || |.|  ..|.  |     || . . ..| .||
dknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD
subfamily_KAPP-like_pd Subfamily KAPP-like 327-467 1.1e-23 76.6 In-house 100-239 (266) alignment 
Range on Protein: 327-467
Range on HMM: 100-239/266.0
SGTTAVVALIR--GKQ--LIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD-GRVNgGLNLSRAIGDHFYKRNkNLppeeQMISAl
 |.|| .||.   |.|  | ||| |||   .|   ..| .|.||| .|. |  |||. |  .. .  |.| || .|||.|||| |.  |.     .||  
eGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfikel.ni....Glise.

PDI-KVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENG
| . . ..||  ..|...| ||.|.|.| .. .. ..|   |.. . 
pyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqated
subfamily_TAB1_pd Subfamily TAB1 327-449 1.7e-15 49.6 In-house 129-262 (333) alignment 
Range on Protein: 327-449
Range on HMM: 129-262/333.0
SGTTAVVALIRGKQLIVANAGDSRCVVSE---AGKALDMSYDHKPEDEVELARIKNAGG---KVTMDGRVnGGLNLSRAIGDHF----YKRNKNLP-PEE
 |||||||||  ..| |||.|||| .. .     |   .| ||. . | || |.|. |    ..   .|. |. .  |.|||.     || .. |   ..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrl.gskentRsiGdykvkkgykdvdilssakg

QMISALPDIKVL-TLTDDHEFMVIACDGIWNVMSS
. . | |||.    ..|   |.|.  ||. . .  
ePviaePdiqgaypiddityflvlmSdGvyktLee
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 339-467 1.1e-21 69.9 In-house 126-249 (276) alignment 
Range on Protein: 339-467
Range on HMM: 126-249/276.0
KQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD-GRVNgGLNLSRAIGDHFYKRNkNLppeeQMISAlPDI-KVLTLTDDHEFM
. | ||| |||   .|   ..| .|.||| .|  |  |||. |  .. .  |.| || .|||.|||| |.  |.     .||  | . . ..||  ..|.
rylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikel.ni....Glise.pyvsnrilltpfdkfl

VIACDGIWNVMSSQEVVDFIQSKISQRDENG
..| ||.|.|.| .. .. ..|   |.. . 
ivasdGlwdvisGkdaiekvkslydqqated
subfamily_PHLPP_pd Subfamily PHLPP 340-458 1.8e-13 43.0 In-house 106-214 (246) alignment 
Range on Protein: 340-458
Range on HMM: 106-214/246.0
QLIVANAGDSRCVVSEAGKALDMSYDHKPEDEvELARIKNAGGKVTMDGRVNGGLNLSRAIGdHFYKRNKNLPPeeqmisalPDIKVLTLTDDHEFMVIA
.| ||. |    |.   || | .|  .. |.. || |||.| . .| |...|| .. .| .| ...     ||         | .. ..||.. |.... 
sLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllG.ytflfPvvlPk........phvrevlLteqdellivG

CDGIWNVMSSQEVVDFIQS
 . .|.|.| .|.|. .. 
nkalWevlsideaveavrk
Subfamily Dicty-PPM1L-like 389-506 2.4e-08 26.2 In-house 200-304 (305) alignment 
Range on Protein: 389-506
Range on HMM: 200-304/305.0
RVNGGLNLSRAIGDHFYKRNKNlPPEEQMIsalpdiKVLTLTDDhEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDT
.||. |. || .||   |     |.... .      .|.. ..| .|.|.| ||.|.|.| |.||.... .. ..  .. .      . ..  .      
lvnrllkksrskGdknlkelvi.Pnndspl......lvvakanD.qflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrg

SGDgtgcdNMTCIIICFK
|||     |.| .|| .|
sgD.....nitlviiklk
subfamily_PPM1H_pd Subfamily PPM1H 389-470 2.6e-08 26.1 In-house 276-361 (404) alignment 
Range on Protein: 389-470
Range on HMM: 276-361/404.0
RVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDD----HEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELR
|. . .  .| .|||  |  ..      ..|. |...|| ||.      . ...| ||.|.|.| .||   ... .|. ... . |
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkr
subfamily_PPM1D_pd Subfamily PPM1D 394-506 1.8e-13 43.2 In-house 201-308 (309) alignment 
Range on Protein: 394-506
Range on HMM: 201-308/309.0
LNLSRAIGDHFyKRnkNLPPEEQMISALPDIKVLTLTDDHE-FMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRllSSIVEELLDQCLApDTSGDG
|...|..|| .     |   .| ..|  ||.|| ||. ..| |...| ||.|||......|...... ...  ..|    .|... |... |   ..   
LavaRslGDlW.sy..naksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs..rsvakalvkealq.rwrskk

TGCDNMTCIIICFK
  .||.. |.....
lraDnvsvivvile
PPM_PTC7_motif 437-489 1.1e-13 44.4 In-house 1-48 (51) alignment 
Range on Protein: 437-489
Range on HMM: 1-48/51.0
VIACDGIWNVMSSQEVVDFIQSKIS-QRDengelrLLSSIVEELLDQCLAPDTS
..|.||.|.|.|.||.||.... .| ...       . .. |.| |..||. ..
iLAsDGLWDvlsdqeavdlvrdqlskkgl......spqeaAeklvdealargse