Gene PPM1M in Homo sapiens

Synonym: PP2C-eta, PP2CE, PP2Ceta, PPM1M

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1H
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP183_AA protein Get Run
HsapP183_AA_54-451 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 55-451 1.8e-53 174.3 In-house 5-292 (295) alignment 
Range on Protein: 55-451
Range on HMM: 5-292/295.0
SRPVRSPARGRTLPWNAGYAEIINAEKSEFNEDQAACGKlcirrcefgaeeE------WltlcpeefltGHYWALFDGHGGPAAAILAANTLHSCLRRQL
|.|.... . ..|...  ..   .  ... |||.  .              .                 ......|||||| ||| .|...|.. |...|
slpllellllsslllllrvgvasdqGrrksneDavlvvl............nllslled..........lllfgvfDGhgGhaaaevasellvelllell

EAVVEGLVATqppmhlngrcicpsdpqfveekgiraEDLVIGALESAFQECDEVIGRELEA--SGQMGGCTALVAVSLQGKLYMANAGDSRAILVRRDEI
| ..  |  .                          .. .. ||..||...|| . .....  . ...|.||.||.  ..|||.||.|||||.|.|..|.
ekllllltls..........................ledieealrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngel

RPLSFEFTP--ETERQRIQQLAfvypellageftrlefprrlkgddlgqkvlfrdhhmsgwsykrveksdlkyplihGQGRQARLLGTLAVSRGLGDHQL
..|... .|  |.||.||...                                                        |  .  |..|.|||.| |||..|
vqltvdhkpvnelererilsag.......................................................gavshgrvngvlavtRalGdfdl

RVLDTNIQLKPFLLSVPQVTVLDVDqleLQEDDVVVMATDGLWDVLSNEQVAWLVRSFLPgnqeDPHRFSKLAQMLIHSTQGkedslteegQVSYDDVSV
 .| ....|.|.. ..|.||||...   |..||....|.||||||||||... .|||.|       .  ...|..|..               |.|...|
klllslllleplvsaePdvtvlelt...ledddfllLasDGlwdvlsneeivdivrslla....kgldleeaaeeLvdlAla.........rgsrDNiTv

FVIPLHS
.|. |..
vvvrlng
subfamily_PPM1H_pd Subfamily PPM1H 61-450 7.4e-174 571.2 In-house 3-403 (404) alignment 
Range on Protein: 61-450
Range on HMM: 3-403/404.0
PARGRTLPWNAGYAEIINAEKSEFNEDQAACGKLCIRRCefgAEEEWLTLCP-----EEFLTGHYWALFDGHGGPAAAILAANTLHSCLRRQLEAVVEGL
|.. |.|||.|||||.|||.|||.||||||. .|.....   ..|...| .|     ||.|. .|..|||||.|..||..|...||..|...||.|.| |
prelrrlPwaaGYaevinagkselneDqaaakvlllkke...kkeksvtskpkekseeeklplayfglfDGhaGsgaalvaskllhkhlkekledvlell

VATQPPMHLNGRCICPSDPQFV----EEKGIRAEDLVIGALESAFQECDEVIGRELEASGQMGGCTALVAVSLQGKLYMANAGDSRAILVRRDEIRPLSF
..... .. |........|..|    ||| |..|.||||||||||.|.||.| || ||  ..||||||||..|.||||.||||||||||||.|||.|||.
leksaeeeenteesskespssvseiyeekeiskeeLviGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsa

EFTPETERQRIQQLAFVYPELLAGEFTRLEFPRRLKGDDLGQKVLFRDHHMSGWSYKRVEKSDLKYPLIHGQGRQARLLGTLAVSRGLGDHQLRVLDTNI
.|||||||||.|.|||..||||. |||||||..||| .||||.||.||..|.||.||.||..|||.|||.|.|..||||.|..|.||||||.|.|.|||.
dftPeteRqRlqelaflkPeLlgkeftrlefqkRlkkkdlgqrvlyRdqnmtGWayktveeeDlkfplisgegkkaRllatigvtRGlGDheLkvvdtnl

QLKPFLLSVPQVTVLDVDQLELQEDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQ-EDPHRFSKLAQMLIHSTQGKEDS----LTEEGQVSYDDVSVFV
..|||| .||.|.|||..|.| .||||...||||||||||||.||..||..|. .. ||..|....||.|.....||...    |.||...|.||.||||
sikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkrytavaqeLvaaarGklkdkgWrlkeekaasvDDisvfv

IPLH
|||.
iPlk
0049733 PP2C-like 81-450 1.8e-39 128.5 In-house 13-234 (235) alignment 
Range on Protein: 81-450
Range on HMM: 13-234/235.0
K-SEFNEDQAACgklcirrcefgaeeewltlcpeeflTGHYWALFDGHGGPAAAILAANTLHSCLRRQLEAvveG---Lvatqppmhlngrcicpsdpqf
.  . |||  ..                          ....|..||||| ||. .|...|...|...|..                             
rvrkvneDavlv.........................glllfavaDGhgghaagevasellvetllellle...lllld.....................

veekgiraedlVIGALESAFQECDEVIGRELEAS--GQMGGCTALVAVSLQGKLYMANAGDSRAILVRRDEIRPLSFEFTP--ETERQRiqqlafvypel
           .. ||..||....|.. .. .||   ...|.||.||.  .||||.||.|||||.|.|......|... .|  |.||||           
...........leealrkaflaaneallelalaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqr...........

lageftrlefprrlkgddlgqkvlfrdhhmsgwsykrveksdlkyplIHGQGRQARLLGTLAVSRGLGDHQLRvldtniqlkpfllsvpqvtvLDVDQLE
                                               |.  |   | .| ||..| |||..|                      || .||
...............................................iitaggavrvpgrlaltralGdlllk....................pdvtvle

LQEDDVVVMATDGLWDVLSNEQVAWLVRSflpgnqedpHRFSKLAQMLIHSTQGkedslteegQVSYDDVSVFVIPLH
|...|....|.||||||||.|... |.||         .  ...|..|..               ..|...| |. |.
lepgdflllasDGlwdvlsdeeivdllrs.........ldleeaaerlvelala.........rggrDNiTvvvvrld
subfamily_PPM1A_pd Subfamily PPM1A 114-264 2.6e-15 49.5 In-house 38-167 (282) alignment 
Range on Protein: 114-264
Range on HMM: 38-167/282.0
EFLTGHYWALFDGHGGPAAAILAANTLHSCLRRqleavveglvatqppmhlngrcicpsDPQFV-EEKGIRAEDLVIGALESAFQECDEVIGRELEASG-
.  .. ..|.||||.|  .|  ....|.. . .                          . ..  ...  . .| |  ||...| . || | .. . .  
alkdwsfFavfDGHaGsevakyvkkhllenile..........................eeelkeaaleasekdevkealrqgfLaldeairelstdlkt

-QMGGCTALVAVSLQGKLYMANAGDSRAILVRRDEIRPLSFEFTP--ETERQRIQQ
 .  |.||....  . .|..||.|||||.|.|  .   |. .  |  ..|..||.|
adksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieq
PP2Cc_SM00332 118-447 4.3e-51 166.9 In-house 40-274 (274) alignment 
Range on Protein: 118-447
Range on HMM: 40-274/274.0
GHYWALFDGHGGPAAAILAANTLHSCLRRQLEAVVEGLvatqppmhlngrcicpsdpqfveekgiraEDLVIGALESAFQECDEVIGRELEASGQ---MG
... ..||||||...| .... |...| ..|. . . |                             || |  ||..||...|| |  | . . .     
wlffgvfDGhgGsevakfvskklpealkeelkkkkdel.............................eddveealkkaflstdeeileeeqskelenals

GCTALVAVSLQGKLYMANAGDSRAILVRRDEIRPLSFEFTP--ETERQRIQQLAFvypellageftrlefprrlkgddlgqkvlfrdhhmsgwsykrvek
|.||.||.  ...||.||.|||||.|.| .....|| . .|  |.||.||.. .                                              
GstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg.............................................

sdlkyplihgQGRQARLLGTLAVSRGLGDHQLRVLDtnIQLKPFLLSVPQVTVLDVdqleLQEDDVVVMATDGLWDVLSNEQVAWLVRSFL-PGNQEDPH
          . .. |. |.||||| .|||.|   .   . .|.. . |.|.|...     .||.....|.|||||||||..| ..||..|  |...||.
..........vvekgrvngglavsrafGdhflkknk..klkepyitaepdvkvvtl....tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpq

RFSKLAQMLIHSTqgkedslteegQVSYDDVSVFVI
....|  ..  ..           . |.|...|.|.
eaaelldeeairr...........ggseDniTvvvv
PP2C_2 Protein phosphatase 2C 118-403 1.6e-06 20.6 Pfam-A 24-195 (212) alignment 
Range on Protein: 118-403
Range on HMM: 24-195/212.0
GHYWALFDGHGGPAAAILAANTLHSCLRRQLEAVVEGLVATQppmhlngrcicpsdpqfveekgiraEDLVIGALESAFQE-C------DEVigrelEAS
|.. |  ||.|  . .  .|. . . . ..||. .|   ...                         |. .. ..|.. .. .       .      ...
gwllaVADGaGsakrSdkGarlaveaagealeklleeeseqe.........................eeallrqieneilasvklkqeaeaq.....qee

GQMGGCTALVAVSLQGKLYMANAGDSRAILVR-RDEIRPLSFEFTPETERQriqqLAFVYPELLAGEFtrlefprrlkgddlgqkvlfrdhhmsgwsykr
 .  ..| |.||   |... .. ||.......  .|...|. . . | ...    . |...|   .|.                                
lkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyane....ttfltsedaeeel................................

veksdlkyplihgqgrqarllgtlavsrglgdhqlrvldtniqlkpfllsvpqvtvlDVDQLELQEDDVVVMATDGLWDVLSNEQ-VAWLVRSFL
                                                         .. .|.|.. | ... |||..| |..|. .. |.. .|
.........................................................rirrlklepgdalllmTDGvsdslrkeepfrellaell
PP2C_2 Protein phosphatase 2C 118-403 1.6e-06 20.6 In-house 24-195 (212) alignment 
Range on Protein: 118-403
Range on HMM: 24-195/212.0
GHYWALFDGHGGPAAAILAANTLHSCLRRQLEAVVEGLVATQppmhlngrcicpsdpqfveekgiraEDLVIGALESAFQE-C------DEVigrelEAS
|.. |  ||.|  . .  .|. . . . ..||. .|   ...                         |. .. ..|.. .. .       .      ...
gwllaVADGaGsakrSdkGarlaveaagealeklleeeseqe.........................eeallrqieneilasvklkqeaeaq.....qee

GQMGGCTALVAVSLQGKLYMANAGDSRAILVR-RDEIRPLSFEFTPETERQriqqLAFVYPELLAGEFtrlefprrlkgddlgqkvlfrdhhmsgwsykr
 .  ..| |.||   |... .. ||.......  .|...|. . . | ...    . |...|   .|.                                
lkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyane....ttfltsedaeeel................................

veksdlkyplihgqgrqarllgtlavsrglgdhqlrvldtniqlkpfllsvpqvtvlDVDQLELQEDDVVVMATDGLWDVLSNEQ-VAWLVRSFL
                                                         .. .|.|.. | ... |||..| |..|. .. |.. .|
.........................................................rirrlklepgdalllmTDGvsdslrkeepfrellaell
subfamily_PPM1G2_pd Subfamily PPM1G2 119-263 2.9e-21 68.7 In-house 53-166 (287) alignment 
Range on Protein: 119-263
Range on HMM: 53-166/287.0
HYWALFDGHGGPAAAILAANTLHSCLRRqleavveglvatqppmhlngrcicpsdpqfveeKGIRAEDLVIGALESAFQECDEVIGRELEASGQMGGCTA
 ..|.|||||| ..|  |.. |.. . .                                 |   .|. .  .|. || |.|| . .. . . .. |.||
alfavfDGhGGakvakyagkklikkiak.................................kksfkegaleqilkdafletDeellkdeklkdesaGsta

LVAVSLQGKLYMANAGDSRAILVRRDEIRPLSFEFTPET--ERQRIQ
.|..  . |||.||||||||.|  . ... |||.  |..  |..||.
vvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkrii
subfamily_PPM1E_pd Subfamily PPM1E 119-265 3e-15 49.1 In-house 41-155 (265) alignment 
Range on Protein: 119-265
Range on HMM: 41-155/265.0
HYWALFDGHGGPAAAILAANTLHSCLRRQLEAVVEGLvatqppmhlngrcicpsdpqfveekgiraedlviGALESAFQECDEVIGRELEASGQMGGCTA
 ..| ||||||  ||  ||. ||. | || ..  . .                                   ||..||...|| . .  |  .  .|.||
affavfDGHgGveaakyaaahlhellvrqeklkedpa..................................ealkeafkltDerflqkaereklksGsta

LVAVSLQGKLYMANAGDSRAILVRRDEIRPLSFEFTPET--ERQRIQQL
 |..  . .||.|  |||.|.|||  |.. |     ||   |..||...
vvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieea
subfamily_PPM1L_pd Subfamily PPM1L 119-264 3.8e-13 42.3 In-house 36-159 (269) alignment 
Range on Protein: 119-264
Range on HMM: 36-159/269.0
HYWALFDGHGGPAAAILAANTLHSCLRRQLEAVveglvatqppmhlngrcicpsD-------PqfveekgIRAEDLVigalESAFQECDEVIGRELEASG
.. |.||||||  ||  | . |   ....|  .                     |       |       |  . |.    .      || .  ..... 
sffavfdGhGGefaaefakdvlvkaiknkliel.....................dadkentep.......infskll....tdeilsvdekllekakrae

QMGGCTALVAVSLQGKLYMANAGDSRAILVRRDE-IRPLSFEFTPET--ERQRIQQ
.. |.|||.|.  . .| .|| |||| .|. ..    ||||.  |.   ||.||..
diaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikk
PPM_PTC7 120-264 8.4e-17 54.4 In-house 36-154 (259) alignment 
Range on Protein: 120-264
Range on HMM: 36-154/259.0
YWALFDGHGGPAAAILAANTLHSCLRRQLEAVVEGlvatqppmhlngrcicpsdpqfveekgiraedLVIGALESAFQE--CDEVIGRELEA-SGQMGGC
. | ||||||  || .|...|. .| .. .                                     ... ||  .|..   ||.. .. ..   . .|.
ffavfdghggreaakyarehleeilkerksfeele................................klekalrksflaldtdeelksseantepstsGs

TALVAVSLQGKLYMANAGDSRAILVRRDEIR-PLSFEFTPET--ERQRIQQ
||.||.  . ||| ||.|||||.|.|..... .|.. ..|.   ||.||..
tAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRieg
subfamily_TAB1_pd Subfamily TAB1 120-265 2.3e-10 32.8 In-house 29-185 (333) alignment 
Range on Protein: 120-265
Range on HMM: 29-185/333.0
YWALFDGHGGPAAAILAANTLHSCLRrqLEAVVEGLVATQPPMHLNgRCICPSDPQFVE--EKGIRAEDLVIGAL------ESAFQECDEVIGRELEASG
 .|.|||. |  || .....| . |   || . . |  ...   |. | .   . .|.|  .. .  .| .   |        .... .| | |  |   
lyavFdGydGnkaakfveqrLvaell..leqltdelaeaevkevlk.rafeeverkflesiddalaekddlqsqlPegvssyeleeqypekierlqelee

-QMGGCTALVAVSLQGKLYMANAGDSRAILVR---RDEIRPLSFEFTPE--TERQRIQQL
   || ||.||. .  ||| ||.|||||.||.    .... || . | .   | .|...|
eisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdL
subfamily_PPM1D_pd Subfamily PPM1D 121-449 2.2e-18 59.4 In-house 38-307 (309) alignment 
Range on Protein: 121-449
Range on HMM: 38-307/309.0
WALFDGHGGPAAAILAANTLHSCLRRQLEAvveglvATQPPMHLngrcicpsdpqfveekgiraedlvIGALESAFQECDEVIGRELEA-----SGQ--M
 |.||||||  ||  | . | | ...| .        ...| ..                        . |...|| .. | . ..||      ||.   
vavfDGHGGkeAakfarehlwsvikkqkkf......lssepedv........................leAireaflatheamkkkleeWpktksgllst

GGCTALVAVSLQGKLYMANAGDSRAILVRRDEirplsfeftpeTErqriqqlAFVYPELLAGEFTRLEFPRRLKGDDLGQKVLFRD-HHMSGWSYKRvek
 | || | .  . |||.|. |||...|  ...           .|        .. .. |  .    .   . . ..|| .|  .   .   |. .|   
aGttasvviirreklyvahvGDsaivlgvkep...........ke.......kklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRpr...

sdlkY----PlihgqgRQARLLGTLAVSRGLGDhqlrVLDTNIQLKPFLLSvPQVTVLdVDQLELQEDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQE
         |      ..   .  |||.| |||    .   | . . |. | |.  |  | .|. .|......|.||||.||. |..  .|..    .. 
....lehngp......tvideiPFLavaRslGD....lWsynaksgefvvs.PePdvk.vrtldpneekfiilasDGlwnvltpedavsvvekeeekkel

DPHRFSKLAQMLIHSTQGKedslTEEGQVSYDDVSVFVIPL
  .. .. |..|.... ..    ... ..  |.||| |. |
keeqsrsvakalvkealqr....wrskklraDnvsvivvil
PP2C_SIG_SM00331 121-446 1.3e-17 57.0 In-house 33-214 (217) alignment 
Range on Protein: 121-446
Range on HMM: 33-214/217.0
WALFDGHGGPAAAILAANTLHSCLRRQLEAVveglvatqppmhlngrcicpsdpqfveekgiraedlviGALESAFQECDEVIGREleASGQMGGCTALV
 ...||.|. .|| .|.  |.. || .|..                                        .|..|.......| .|  .  . ...|.|.
lvvaDgmGkGlaAaaassqlrtalrellseg......................................eelsqalkrlnraiyee..keekgmfaTlll

AVS--LQGKLYMANAGDSRAILVR-RDEIRPLSFeftpeterqriqqlafvypellageftrlefprrlkgddlgqkvlfrdhhmsgwsykrveksdlky
|.    .|||..||||||| .|.| .... .|..                                                                  
alydfssgklsyanaGdsrpyllrdgklveilkd..................................................................

plihgqgrqarllgtlavsrglgdhqlrvldtniqLKPFLLSVPQVTVLDVDQLELQEDDVVVMATDGLWDVL-----SNEQVAWLVRSFLpgnQEDPHR
                                    ....|.. .   .|. .|||...|.....||||...       .|..  ......   .. . .
...................................vegaplGlepevsvdirelelekgdllllytDGltearsekgfaeerleeiledlv...dseaqe

FSK-LAQMLIHSTQGKEDslteegqvsYDDVSVFV
 ..   . |.....|..           ||..| |
laqkiveellelakgsng.........eDdiTvvv
subfamily_KAPP-like_pd Subfamily KAPP-like 121-264 3.8e-06 19.1 In-house 37-156 (266) alignment 
Range on Protein: 121-264
Range on HMM: 37-156/266.0
WALFDGHGGPAAAILAANTLHSCLRRQLEAvveglvatqppmhlngrcicpsdpqFVEEKGIRAEDLVIGALESAFQECDEVIgRELEASgqmgGCTALV
.|.|||| |  ||  | . .   | ..|.                            ...|        . || ||.| |. . .. |      |.|| .
favfdGhaGkGaadaakklfpkelekllks.........................tkqddGGdniydqskllenafkevdakl.kdfeye....Gatatl

AV----SLQGKLYMANAGDSRAILVRRDEIRPLSFEF--TPETERQRIQQ
|.      |  |  || ||| |.| | .|   ||..   . . |.|||..
alvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikd
PPM_PTC7_SpoIIE 123-406 9.1e-21 67.7 In-house 39-212 (230) alignment 
Range on Protein: 123-406
Range on HMM: 39-212/230.0
LFDGHGGPAaaILAANTLHSCLRRQLEAVVEglvatqppmhlngrcicpsdpqfveekgiraedLVIGALESAFQECDEVIGREleasGQMGGCTALVAV
 .|||||.|   ||...|...||..  |  |                                 ..  .|. ......  .  |     . .|.||.||.
dvdGhGgra..alamgllrtalrelafagle.................................kpeeilrrlnlalaadlede....psssgaTavval

--SLQGKLYMANAGDSRAILVRRDEIrplsfeftpetERQRIQQLAFVY----PEllageftrlefprrlkgddlgqkvlfrdhhmsgwsykrveksdlk
  . .||||.||||||...||| |.            || ||.   ...    |.                                             
idpstgklyvanaGdsppllvrddgg...........ererivagglpslGilpg.............................................

yplihgqgrqaRLLGTLAVSRGLGDHQLRVldtniqlkpfllSVPQVTVL--DVDQLELQEDDVVVMATDGLWDVLSNEQVAWLVRSFLPGN
           |  |.||||.  ||  |              .   |.    ..| .  ..|. ...|.||||||||..... |||. |  .
...........rvfgvlavslapGdlllly............tDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp
PP2C Protein phosphatase 2C 185-265 7.3e-15 48.2 Pfam-A 69-154 (255) alignment 
Range on Protein: 185-265
Range on HMM: 69-154/255.0
EDLVIGALESAFQE-CDEVIGRELEA-SGQMGGCTALVAVSLQGKLYMANAGDSRAILVRRDEIR-PLSFEFTPE--TERQRIQQL
 ..|  || ..|..  ||.. .. .. . .  |.||.||.  . ||| ||.|||||.|.|.|...  |..  .|.   ||.||...
lekvekalrksfladtdeelksskantepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeea
PP2C Protein phosphatase 2C 185-265 7.3e-15 48.2 In-house 69-154 (255) alignment 
Range on Protein: 185-265
Range on HMM: 69-154/255.0
EDLVIGALESAFQE-CDEVIGRELEA-SGQMGGCTALVAVSLQGKLYMANAGDSRAILVRRDEIR-PLSFEFTPE--TERQRIQQL
 ..|  || ..|..  ||.. .. .. . .  |.||.||.  . ||| ||.|||||.|.|.|...  |..  .|.   ||.||...
lekvekalrksfladtdeelksskantepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeea
subfamily_PPM1K_pd Subfamily PPM1K 191-264 3.9e-09 29.0 In-house 70-151 (263) alignment 
Range on Protein: 191-264
Range on HMM: 70-151/263.0
ALESAFQECDEVIGRELEAS-----GQMGGCTALVAVSLQGK-LYMANAGDSRAILVRRDEIRPLSFEFTPE--TERQRIQQ
 |  ||.|.|. . | || |      .  | || |..  .|. | .|. ||||||| |. . . |. . .||  .|..||..
vlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerika
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 192-265 5.2e-08 25.5 In-house 77-149 (255) alignment 
Range on Protein: 192-265
Range on HMM: 77-149/255.0
LESAFQECDEVIgrelEASGQMGGCTALVAVSLQGKLYMANAGDSRAILVRRDEI-RPLSFEFTPE--TERQRIQQL
|. |..| .  |    .  ... |.|| ... .. | |.|| ||||..| ..| . . ||..  |    |..||..|
lkkaykeistqi....serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekrisel
subfamily_PPM1G_pd Subfamily PPM1G 205-263 6.8e-10 31.5 In-house 287-347 (473) alignment 
Range on Protein: 205-263
Range on HMM: 287-347/473.0
RELEASGQMGGCTALVAVSLQGKLYMANAGDSRAILVRRDEIRPLSFEFTPE--TERQRIQ
 | |. |.  |.|| ||.  . ||..|||||||..| |  .   || .  ||  .|..||.
eekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRie
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 210-264 5.4e-08 25.7 In-house 81-143 (292) alignment 
Range on Protein: 210-264
Range on HMM: 81-143/292.0
SGQMGGCTALVAVSLQG-KLYMANAGDSRAILVR-----RDEIRPLSFEFTPE--TERQRIQQ
 .. .. ..  |.   . .|..|| |||||.| |     . |..||| .  ||   ||.||..
aresattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilr
subfamily_ILKAP_pd Subfamily ILKAP 214-263 4.1e-07 22.4 In-house 113-170 (293) alignment 
Range on Protein: 214-263
Range on HMM: 113-170/293.0
GGCTALVAVSLQGKLYMANAGDSRAILVRRDEIR------PLSFEFTPE--TERQRIQ
 |.|| | . |.  ||.|| |||.|.|||..|        .|. . ||    ||.|||
dGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriq
subfamily_PP2D1_pd Subfamily PP2D1 297-408 1.6e-13 43.2 In-house 212-311 (492) alignment 
Range on Protein: 297-408
Range on HMM: 212-311/492.0
FRDHHMSGW-SYKRVEKSDlkyPLIHGQGRQARLLGTLAVSRGLGDHqlrvldTNIQLKPFLLSVPQVTVLDVDQlelqEDDVVVMATDGLWDVLSNEQV
 |.| .      .||||.      .. ......  | | . |||| .       . .||  ..  |..|   .|.    .. ..|.|. |||.|||.|.|
treHtprnkkERtRvekag...svvvkseknglvnGildttRGLGny......GdpkLkksvipePkttsvklde....aaqflvlAsnGlWevlseeev

AWLVRSFLPGNQE
. ||...|.  ..
lsLvkqtlaiyks
PP2C Protein phosphatase 2C 308-414 4.7e-16 52.1 Pfam-A 149-239 (255) alignment 
Range on Protein: 308-414
Range on HMM: 149-239/255.0
KRVEKSDLKYPLihgqgrQARLLGTLAVSRGLGDHQLRVLDtniqlKPFLLSVPQVTvldVDQLELQeDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQ
.|.|... .         . |. |.||||| |||..|   .     ...  . |.||   . .|. . |. ...|.||||||||..... ||||.|  ..
eRIeeaggsvsn......ngrvngsLavsRalGdfelkpke.....eqlvsaePdvt...svkltee.defliLasdGlwdvlsdqeavdlvrselskkk

eDPHRFS
 .| ...
.spmeaa
PP2C Protein phosphatase 2C 308-414 4.7e-16 52.1 In-house 149-239 (255) alignment 
Range on Protein: 308-414
Range on HMM: 149-239/255.0
KRVEKSDLKYPLihgqgrQARLLGTLAVSRGLGDHQLRVLDtniqlKPFLLSVPQVTvldVDQLELQeDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQ
.|.|... .         . |. |.||||| |||..|   .     ...  . |.||   . .|. . |. ...|.||||||||..... ||||.|  ..
eRIeeaggsvsn......ngrvngsLavsRalGdfelkpke.....eqlvsaePdvt...svkltee.defliLasdGlwdvlsdqeavdlvrselskkk

eDPHRFS
 .| ...
.spmeaa
subfamily_KAPP-like_pd Subfamily KAPP-like 316-428 3.4e-09 29.1 In-house 155-257 (266) alignment 
Range on Protein: 316-428
Range on HMM: 155-257/266.0
KYPLIHGQGRQARLLGtLAVSRGLGDHQLRVLDTNIQLKPFLLSVPQVTvldvdqlelQEDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQEDPHRFSK
|   |     |.|. | ||||| |||| .. |.  .  .|.. .   .|           |. ...|.||||||.| ..    |.|.   .. . .  | 
kddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrillt.........pfdkflivasdGlwdvisGkdaiekvkslydqqatedkmass

LAQMLIHSTQGKE
| .  |.|.. |.
lletaiqsikakd
PPM_PTC7 320-414 1.4e-14 47.2 In-house 162-243 (259) alignment 
Range on Protein: 320-414
Range on HMM: 162-243/259.0
IhgqgRQARLLGTLAVSRGLGDHQLRVLDTniqLKPFLLSVPQVTvldVDQLELQeDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNqeDPHRFS
.    .. |. |.||||| .||..|    |    .. . . |...   . ... . |. ...|.||||||.|..... ||||.|  .  || ...
v....gngrvngvlavsRafGdfelkpket...eeqlvsaePdis...stkidee.defliLasdGlwdvvsdqeavdlvrselskk..dpmeaa
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 320-428 3.6e-09 28.9 In-house 169-267 (276) alignment 
Range on Protein: 320-428
Range on HMM: 169-267/276.0
IHGQGRQARLLGtLAVSRGLGDHQLRVLDTNIQLKPFLLSVPQVTvldvdqlelQEDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQEDPHRFSKLAQM
|     |.|. | ||||| |||| .. |.  .  .|.. .   .|           |. ...|.||||||.| ..    |.|.   .. . .  | | . 
itlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrillt.........pfdkflivasdGlwdvisGkdaiekvkslydqqatedkmassllet

LIHSTQGKE
 |.|.. |.
aiqsikakd
subfamily_ILKAP_pd Subfamily ILKAP 322-407 6.4e-08 25.1 In-house 174-247 (293) alignment 
Range on Protein: 322-407
Range on HMM: 174-247/293.0
GQGRQARLLGTLAVSRGLGDHQLRVLDtniqlkpfLLSVPQVTvldvdQLELQE-DDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQ
|. |. |.|| | ||| .|| . . |         . |.|.|.     ..||.| |  ||.| ||||.|.|...|.  . . |  ..
gvvrdgrvlGvlevsrsiGdgrfkrlG........vistPdvk.....kceLtendlfvvlaCdGLwkvfsadevvkfilkvledee
subfamily_PDP_pd Subfamily PDP 325-415 4.4e-10 32.2 In-house 221-325 (398) alignment 
Range on Protein: 325-415
Range on HMM: 221-325/398.0
RQARLLGTLAVSRGLGDHQLRVLDTnIQL-----------KP-FLLSVPQVTV-LDVDQLELQ-EDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQEDP
|. ||||.|. .|  || ...     .|            .|  . . | .|   .| . .|. .|  .|.|||||||.||||.|. ||  .| ...|. 
rngRlLgeLqPlRAFGdvryKwsee.lqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkeke

HR-FSK
.   ..
pvkvee
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 325-398 1.1e-08 27.7 In-house 158-219 (255) alignment 
Range on Protein: 325-398
Range on HMM: 158-219/255.0
RQARLLGTLAVSRGLGDhqlrvldtnIQLKPFLLSVPQVTVldvDQLELQEDDVVVMATDGLWDVLSNEQVAWL
  .|. ||||||| |||         . |.||... |...         ..|  ...| ||.||..|.|.   .
vtsrvnGtlavsralGd.........sflePfvvpdPdlsq...sleiskkdkflilacdGiwdlisdeeavei
subfamily_PPM1A_pd Subfamily PPM1A 326-412 4.1e-16 52.2 In-house 174-255 (282) alignment 
Range on Protein: 326-412
Range on HMM: 174-255/282.0
QARLLGTLAVSRGLGDHQLRVLDTNIQLKPFLLSVPQVTVLDVDqlelQEDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNqEDPHR
  |. |.||||| |||....  ..  . .  . ..|.||... .    .||| .|.| ||.|||||.|.|. |||. |  . .....
vsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsiers....eeddflvlacDGiwDvlsdeevvelvrkrleva.delee
subfamily_PPM1G2_pd Subfamily PPM1G2 326-449 2.5e-13 42.6 In-house 174-286 (287) alignment 
Range on Protein: 326-449
Range on HMM: 174-286/287.0
QARLLGTLAVSRGLGDHQLRVLDTNIQLKPFLLSVPQVTVLDVDqlelQEDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNqedpHRFSKLAQMLIHSTQ
  |  |.||.|| |||.. .  ..          || |.| ..|    ..|. .|.| ||.||||.|..|  |||. |  .    .. ..... |.... 
lnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkld....eddeflvLaCDGiWDvltnkevvdlvrerlvsg....akldeiieelldkcl

GKEdslTEEGQVSYDDVSVFVIPL
 ..   .... |  |...| .. |
apd...ssntgvGcDnmtvvivvl
subfamily_PPM1E_pd Subfamily PPM1E 326-426 1.4e-11 37.1 In-house 164-248 (265) alignment 
Range on Protein: 326-426
Range on HMM: 164-248/265.0
QARLLGTLAVSRGLGDHQlrvldtniqLKPFLLSVPQVTVLDVDQlelqEDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQEDphrFSKLAQMLIHSTQ
. |  |.|.||| .|| .         |||.. . ..|. ...|.    .......|.||||||. .|.|  ||..||  ..||    |..|..|... .
awRvnGvLsvsRaiGDvk.........lkpyvsgeadvaeveldg....seeylilacDGlwDvvneeevvklveefladgaed...lsevakllveaak

G
 
e
subfamily_PPM1G_pd Subfamily PPM1G 327-421 3.6e-09 29.1 In-house 357-445 (473) alignment 
Range on Protein: 327-421
Range on HMM: 357-445/473.0
ARLLGTLAVSRGLGDHQLRVlDTNIQLKPFLLSvpqvTVLDVDQLELQ-EDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQEDphRFSKLAQMLI
 |. | | .|| ||||  .  .....||  ..|     . |. .|.|. ||. .|.|.||.|.|.. ..|   ||. |  ..|.    |.. . |.
gRvnGGLnlsRAlGDhaYkk.neeLplkeqmis....AlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees..vlseiveeLl
subfamily_PPM1L_pd Subfamily PPM1L 328-401 1.2e-08 27.6 In-house 171-234 (269) alignment 
Range on Protein: 328-401
Range on HMM: 171-234/269.0
RLLGTLAVSRGLGDHQLRvlDTNiqlkpFLLSVPQVTVLDVDQLelqEDDVVVMATDGLWDVLSNEQVAWLVRS
|. | ||.|| |||. |.  | |     .... |..  .|.|..   . . ...|.||||| .|||.    .. 
rvaGvlatsralGdyplk..dkn.....lviadpdiltfdlddh...kpeflilasdGlwdtfsneeavrfike
SpoIIE Stage II sporulation protein E (SpoIIE) 357-447 5.3e-07 21.6 Pfam-A 105-190 (193) alignment 
Range on Protein: 357-447
Range on HMM: 105-190/193.0
LLSVPQVTVLDVDQLELQEDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQED-PHRFSKLAQMLIHSTQGkedsltEEGQVSYDDVSVFVI
.|.. . .  .. .|.|...|.....|||. .  . ..  .    .|  ..|   .. ..|.. |.....        ...   ||....|.
plGilpeadyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle......lgsgeleDDitllvl
SpoIIE Stage II sporulation protein E (SpoIIE) 357-447 5.3e-07 21.6 In-house 105-190 (193) alignment 
Range on Protein: 357-447
Range on HMM: 105-190/193.0
LLSVPQVTVLDVDQLELQEDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQED-PHRFSKLAQMLIHSTQGkedsltEEGQVSYDDVSVFVI
.|.. . .  .. .|.|...|.....|||. .  . ..  .    .|  ..|   .. ..|.. |.....        ...   ||....|.
plGilpeadyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle......lgsgeleDDitllvl
PPM_PTC7_SpoIIE_motif 367-447 7.3e-09 29.2 In-house 3-78 (81) alignment 
Range on Protein: 367-447
Range on HMM: 3-78/81.0
DVDQLELQEDDVVVMATDGLWDVLsNEQVAW----LVRSFLPGNqeDPHRFSKLAQMLIHSTQGkedsltEEGQVSYDDVSVFVI
|. ...|...||....||||..   ...  .     . .... .  . ..  .||..|... .         .. . ||....|.
deaefqLkpgdvllLyTDGltEar.dsdgelfgkeellrladra..egkslqeladklvdevle......ngsgereDDitllvl
subfamily_PPTC7_pd Subfamily PPTC7 367-422 2.2e-08 26.8 In-house 158-210 (252) alignment 
Range on Protein: 367-422
Range on HMM: 158-210/252.0
DVDQLELQEDDVVVMATDGLWDVLSNEQVAWLVRSFlpgNQEDPHRFSKLAQMLIH
|. .......|..|.|||||.| |......  ..     .......  .||. |..
dsksfavkkgDiivlatDGlfDNlledeileilkel...keseksslqslakklae
PPM_PTC7_motif 380-415 1.5e-08 28.0 In-house 1-36 (51) alignment 
Range on Protein: 380-415
Range on HMM: 1-36/51.0
VMATDGLWDVLSNEQVAWLVRSFLP-GNQeDPHRFSK
..|.||||||||....  |||..|   .. .| ....
iLAsDGLWDvlsdqeavdlvrdqlskkgl.spqeaAe