Gene PPTC7 in Homo sapiens

Synonym: TA-PP2C, TAPP2C, PPTC7

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PTC7
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP186_AA protein Get Run
HsapP186_AA_45-296 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PPM_PTC7_SpoIIE 46-295 1.7e-19 63.6 In-house 10-225 (230) alignment 
Range on Protein: 46-295
Range on HMM: 10-225/230.0
DFRKGLLKKGACYGDDACFvARHRSADVLGVADGvggwrdYGVDPsQFSGTLMRtceRLVKEGRFVPSN-PIGILTTSYCELLQNKVPL--LGSSTACIV
..||... ..... . ..   ..|.| |.|..||       |..  ..  .|.|    ...| .|  .. |  ||. ....| ..       . .||...
garksmedahispanseks.sggrlalvvgdvdG......hGgra.alamgllr...talrelafaglekpeeilrrlnlalaadledepsssgaTavva

VLDRTSHRLHTANLGDSGFLVVRGGEVvhrsdeqqhyfntpfqlSIAPPEAEGVV-LSDSP-DAADSTSFDVQLGDIILTATDGLFDNMPDyMILQEL--
..| ....|..||.||| .|.||...                   . ...| | . |.  |   ......  . ||..| .|||. .. ||  .  ||  
lidpstgklyvanaGdsppllvrddgg.................ererivagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.tsdgelfg

-KKLK--NS----NYESIQQTARSIAEQAHELaydpnymspfaqfacdnglNVRGGKPDDITVL
  ..   .|    .. | |. .. . .. ...                   . .|.. ||||.|
kdeflilasdglwdvlspqelvdlvrdelekp...................aaeglleDDitll
subfamily_PPTC7_pd Subfamily PPTC7 54-299 3.4e-112 366.9 In-house 6-251 (252) alignment 
Range on Protein: 54-299
Range on HMM: 6-251/252.0
KGACYGDDACFVARHRSADVLGVADGVGGWRDYGVDPSQFSGTLMRTCERLVKEGRFVPSNPIGILTTSYCELLQNKVPLLGSSTACIVVLDRTSHRLHT
| ...|.||.||....|||||||||||||||..|.|||.|| .||..||.|.||... ...|. .|...|.|||..|||.||||||||||||.....|..
krqkageDayfvsseksadvlgvADGVggWrsvGiDpsefsreLmkaceklskeskaeelkPvelleaayqelleekvpvlGssTacivvldksdkkles

ANLGDSGFLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPEAEGVVLSDSPDAADSTSFDVQLGDIILTATDGLFDNMPDYMILQELKKLKNSNYESIQQTA
|||||||||||| |.||.||.||||.||||.||||||...|| |..|.|.||||.||.|. ||||. ||||||||... .||..||.||.|...|.|..|
anlGDSgflvvRkgkvvfrskeqqhkfntPyQLsiapegregkvildkpeaadsksfavkkgDiivlatDGlfDNlledeileilkelkeseksslqsla

RSIAEQAHELAYDPNYMSPFAQFACDNGLNVRGGKPDDITVLLSIV
...||.|.||..||.|.||||| |..|||...|||||||||... |
kklaekarelsldpeyespfaqkakkngleasGGKpDDitvvvavv
0049733 PP2C-like 57-296 5.1e-34 110.7 In-house 16-230 (235) alignment 
Range on Protein: 57-296
Range on HMM: 16-230/235.0
CYGDDACFVarhrSADVLGVADGVGGWRDYGVDPSQFSGTLMRTCERlvkegrFVPSNPIGILTTSYCEL--------LQNKVPLLGSSTACIVVLDrtS
 ...||..|    .  ...||||.||..  .|  ...  ||.. ...      . . ... .|. .. ..        |...    . .||....||  .
kvneDavlv....glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspelagmgtTavvalld..g

HRLHTANLGDSGFLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPEAEGVV--------LSDSPDAADSTSFDVQLGDIILTATDGLFDNMPDYMILQELKK
..|..||.||| ....|.|..|... ..........|  |.. .|  |         | |..  .| |..... ||..| |.|||.|...| .|.. |..
gklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggavrvpgrlaltralGdlllkpdvtvlelepgdflllasDGlwdvlsdeeivdllrs

lknsnyESIQQTARSIAEQAHElaydpnymspfaqfacdnglnvrGGKPDDITVLL
       .... |. ..|.|..                       .|..|.|||..
......ldleeaaerlvelala.......................rggrDNiTvvv
0034914 PP2C-like 58-296 2.6e-27 88.6 In-house 34-287 (295) alignment 
Range on Protein: 58-296
Range on HMM: 34-287/295.0
YGDDACFVAR-----HRSADVLGVADGVGGWRDYGVDPSQFSGTLMRTCERLVKEGRFVPSNPIGILTTSYCEL--------LQNKVPLLGSSTACIVVL
. .||..| .     ...  ..||.||.||..   |  . .  .|.. .|.|.    . . ... .|.... ..        |...  . ...||.....
sneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallrpelagsGtTavvali

drTSHRLHTANLGDSGFLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPEA-----------------------------EGVVLSDSPDAAdSTSFDVQLG
  ....|..||.||| ....|.||.|. . .. ..... ..  ... .|                             .. ..|  ||   ....... .
..rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvt.vleltledd

DIILTATDGLFDNMPDYMILQELKKLKNsNYESIQQTARSIAEQAHElaydpnymspfaqfacdnglnvrGGKPDDITVLL
|..| |.|||.|....  |.. ...| . .. .... |. ....| .                       .|. |.|||..
dfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAla.......................rgsrDNiTvvv
PP2C_SIG_SM00331 59-296 2.4e-22 72.5 In-house 18-214 (217) alignment 
Range on Protein: 59-296
Range on HMM: 18-214/217.0
GDDACFVARHRSADVLGVADGVGgwrdYGVDPSQFSGTLMRTCERLVKEGrfvpsNPIGILTTSYCELLQNK-VPLLGSSTACIVVLDRTSHRLHTANLG
||  ..|. .    .| ||||.|     |.. . .|. |    . |..||     . .  .    ....... .   .  |... ..| .|..|. ||.|
GDyydvvklnegrlllvvaDgmG....kGlaAaaassqlrtalrellseg.....eelsqalkrlnraiyeekeekgmfaTlllalydfssgklsyanaG

DSGFLVVRGGEVVHRSDEqqhyfNTPFQLSIAPPEAegvvlsdspdaADSTSFDVQLGDIILTATDGLFDNMPD-----YMILQELKKLKnsnYESIQQT
|| ....| |. |.. ..     .....|.. | .            .|....... ||..| .||||.... .     . . . |..|     .. |. 
dsrpyllrdgklveilkd.....vegaplGlepevs...........vdirelelekgdllllytDGltearsekgfaeerleeiledlv...dseaqel

ARSIAEQAHELAYDPNYmspfaqfacdnglnvrggkPDDITVLL
|..| |.. ||| ..|.                   .|||||..
aqkiveellelakgsng...................eDdiTvvv
PP2C_2 Protein phosphatase 2C 60-238 1.7e-08 27.1 Pfam-A 13-190 (212) alignment 
Range on Protein: 60-238
Range on HMM: 13-190/212.0
DDACFVARHRSADVLGVADGVGGWRdYGVDPSQFS-GTLMRTCERLVKEGRFV-PSNPIGILTTSYC-------ELLQNKVPLLGSSTACIVVLdRTSHR
.||... . .....| ||||.|  . ..   ...   ..... |.|..|...   .  .  ... .        |  ... .|   .|...... .|...
qDalaireasdgwllaVADGaGsak.rSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllav.itpge

LHTANLGDSGFLVVRGGEVVHRS--DEQQHYFNTpfQLSIAPPEAEGVVlsdspdaaDSTSFDVQLGDIILTATDGLFDNMPDYMILQEL
.  ...||.. .|...   |..   .... | |.    .. ...||. .        .  ..... || .|  |||. |.. ..  ..||
ivffqiGDgaivvrdrdgevqllgepdsgeyane..ttfltsedaeeel........rirrlklepgdalllmTDGvsdslrkeepfrel
PP2C_2 Protein phosphatase 2C 60-238 1.7e-08 27.1 In-house 13-190 (212) alignment 
Range on Protein: 60-238
Range on HMM: 13-190/212.0
DDACFVARHRSADVLGVADGVGGWRdYGVDPSQFS-GTLMRTCERLVKEGRFV-PSNPIGILTTSYC-------ELLQNKVPLLGSSTACIVVLdRTSHR
.||... . .....| ||||.|  . ..   ...   ..... |.|..|...   .  .  ... .        |  ... .|   .|...... .|...
qDalaireasdgwllaVADGaGsak.rSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllav.itpge

LHTANLGDSGFLVVRGGEVVHRS--DEQQHYFNTpfQLSIAPPEAEGVVlsdspdaaDSTSFDVQLGDIILTATDGLFDNMPDYMILQEL
.  ...||.. .|...   |..   .... | |.    .. ...||. .        .  ..... || .|  |||. |.. ..  ..||
ivffqiGDgaivvrdrdgevqllgepdsgeyane..ttfltsedaeeel........rirrlklepgdalllmTDGvsdslrkeepfrel
PPM_PTC7 66-296 1.5e-18 60.2 In-house 11-246 (259) alignment 
Range on Protein: 66-296
Range on HMM: 11-246/259.0
ARHRSADVLGVADGVG--GWRDYGVDPSQFSGTLMRTCERLVK---------EGRFVPS-NPIGILTTSYCELLQNKVPLL-------GSSTACIVVLDR
.|. . |.........  ...|.  . ..|.|...|.......         . .| .. ... .|..|...| ....  .        .| ...||.  
frksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsGstAvvali

TSHRLHTANLGDSGFLVVRGGEVVHRSDEQQHYFNTpfqLSIAPPEAEGVVLSDSpdaADSTSFDVqlgdIILTATDGLFDNMPDYMilqELKKLKNSNY
|...|..||.|||.....|.|..|..  |...  |.     ..  |..|. .|.    .... ..|    . .. . | |...|...   | ........
tgsklyvAnvGDSravLcrsgnavkqltedHkpsne...dEreRiegaggsvsnv...gngrvngv....lavsRafGdfelkpket...eeqlvsaePd

ESiqQTARSIAeQAHELAYDPNYMSPFA-QFACDNGLNVRGG-KPDDITVLL
 |  .|...   . . . .. .... .. | |.|.  ...   .|....  |
is..stkidee.defliLasdGlwdvvsdqeavdlvrselskkdpmeaaekl
SpoIIE Stage II sporulation protein E (SpoIIE) 74-296 3.3e-17 54.9 Pfam-A 7-189 (193) alignment 
Range on Protein: 74-296
Range on HMM: 7-189/193.0
LGVADGVGgwrdYGVDPSQFSGTLMRTCERLVKEGRFvPSNPIGILTTSYCELLQNKvplLGSSTACIVVLDRTSHRLHTANLGDSGFLVVRGGEvvhRS
|.|.|.||     |.. . ..| |  . ..|...|   |.. .. | .  .. |...       ||.....|  ...|. ||.|.. .|.||. .   . 
lvvgDvvG....hGleAalimgllrsalrelatagle.paevlerlnealarnleee...erfatavlaeydpstgkleyanaGhpppllvrpdg...gt

DEQQHYFNTPfqLSIAPPeaegvvlsdspDAADSTSFDVQLGDIILTATDGLFDNMPDYMIL----QELKKLKNSNYESIQQTARSIAEQAHElaydpny
 .. . .. |  |.| |              ......... ||..| .|||..... .   |    . |. |...  || ....... |...|       
kfllvstglp..lGilpe...........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle.......

mspfaqfacdnglNVRGGKPDDITVLL
             . .|.. ||||.|.
.............lgsgeleDDitllv
SpoIIE Stage II sporulation protein E (SpoIIE) 74-296 3.3e-17 54.9 In-house 7-189 (193) alignment 
Range on Protein: 74-296
Range on HMM: 7-189/193.0
LGVADGVGgwrdYGVDPSQFSGTLMRTCERLVKEGRFvPSNPIGILTTSYCELLQNKvplLGSSTACIVVLDRTSHRLHTANLGDSGFLVVRGGEvvhRS
|.|.|.||     |.. . ..| |  . ..|...|   |.. .. | .  .. |...       ||.....|  ...|. ||.|.. .|.||. .   . 
lvvgDvvG....hGleAalimgllrsalrelatagle.paevlerlnealarnleee...erfatavlaeydpstgkleyanaGhpppllvrpdg...gt

DEQQHYFNTPfqLSIAPPeaegvvlsdspDAADSTSFDVQLGDIILTATDGLFDNMPDYMIL----QELKKLKNSNYESIQQTARSIAEQAHElaydpny
 .. . .. |  |.| |              ......... ||..| .|||..... .   |    . |. |...  || ....... |...|       
kfllvstglp..lGilpe...........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle.......

mspfaqfacdnglNVRGGKPDDITVLL
             . .|.. ||||.|.
.............lgsgeleDDitllv
PPM_PTC7_SpoIIE_motif 205-296 1e-09 32.0 In-house 2-77 (81) alignment 
Range on Protein: 205-296
Range on HMM: 2-77/81.0
ADSTSFDVQLGDIILTATDGLFDNMPD---YMILQELKKLKNSNyE--SIQQTARSIAEQAHElaydpnymspfaqfacdnglNVRGGKPDDITVLL
.|...|... ||..| .||||.... .    .  .|| .| ... |  | |. |. . ....|                    | .|.. ||||.|.
ydeaefqLkpgdvllLyTDGltEardsdgelfgkeellrladra.egkslqeladklvdevle....................ngsgereDDitllv
PPM_PTC7_motif 220-269 3.9e-12 39.5 In-house 2-51 (51) alignment 
Range on Protein: 220-269
Range on HMM: 2-51/51.0
TATDGLFDNMPDYMILQELKKLKNSNYESIQQTARSIAEQAHELAYDPNY
 |.|||.|...|... . ...  .....| |. |. ....|.. ....|.
LAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni