Gene PPP2C-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP099_AA protein Get Run
MbreP099_AA_3-294 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 4-294 8.4e-115 377.0 In-house 27-329 (473) alignment 
Range on Protein: 4-294
Range on HMM: 27-329/473.0
TSDLDAQIEQIRSGKQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVR
 .|||. ||... ...| | ... |...|||||..|.|. |.| ...|.||.|||..|||.|... |  | ....|.||.||||..|.| . || |||..
lldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkik

YPERISILRGNHESRQITQVYGFYDECLRKYaSPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDR
||... .||||||.|.....|||.||.|.|| .  .. .| .... |||. ... .|.. ||||||. ..|| || ..|..|.|..|...|||||||.. 
ypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwed

AG--------WNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRN------VVTIFSAPNYCYRCGNQGGIMELDDTLnYSFLQYDPA
 |        .  ||||||. ||. . ||| . |||..| |.|. |.||... .|..      ..|.|||||||.|.|| ......|..| .|| |.||.
dgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdps

PRPQG
| |. 
phpli
0049330 Metallo-dependent phosphatases 4-293 3.1e-108 354.4 In-house 14-303 (309) alignment 
Range on Protein: 4-293
Range on HMM: 14-303/309.0
TSDLDAQIEQIRSGKQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVR
.|.||..||... .|.|.|....||..|||||| .|.|. |.| ...|.||.|||..|||.|... | .| ....|.||.||||..|.| ..|| |||..
lslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkll

YPERISILRGNHESRQITQVYGFYDECLRKYAsPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPD-D
||... .||||||.|.....|||.||.||||. . .| .|.|... |||. ... .|.| ||||||. ..|| ||...|..|.|..|..||||||||. .
ypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpi

RAGWNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDPAPRPQ
| |.  .|||.|. || |. |.| ..|||. | |.|..|..|. . .|....|.|||||||.|.||.|...|.|..|..|||...|.|...
regfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll
subfamily_PPP2C_pd Subfamily PPP2C 5-292 1.3e-177 582.1 In-house 2-289 (290) alignment 
Range on Protein: 5-292
Range on HMM: 2-289/290.0
SDLDAQIEQIRSGKQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRY
.|||..||.....|||.|...| ||||||||||.||||.||.|||||||||||||.||||||.|||..|.|||||.||||||||.|||.|||||||||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PERISILRGNHESRQITQVYGFYDECLRKYASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDRA
.|||.|||||||||||||||||||||||||....||.|||||||.||||.||..|||||||||||...|||.||..||.||||||||.|||||||||||.
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDPAPRP
||..||||||..|||..||.||.||||..|||||||||||.||||||||||||||||||||||||..|.||||.|.|||||.||||| 
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_PPP4C_pd Subfamily PPP4C 5-289 2.5e-142 466.3 In-house 1-285 (288) alignment 
Range on Protein: 5-289
Range on HMM: 1-285/288.0
SDLDAQIEQIRSGKQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRY
|||| |||..|. . . |...| ||.||.||| .||||..| .|||||||.|||||||||||..||.||.|||||.||.||||..|||.  ||.||||||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PERISILRGNHESRQITQVYGFYDECLRKYASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDRA
|.||...||||||||||||||||||||||| | .|| | |..||.|.|. ... .|||.||||||. .||| || .|| ||||||||.||||||||.|  
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

GWNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDPA
||.|||||||. ||. |.|.||..|.. .|.|||||||||...  ...|.|..|||||||||||   |.|||..|.. |  .. |
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
0053225 Metallo-dependent phosphatases 5-290 4.5e-104 340.8 In-house 7-292 (293) alignment 
Range on Protein: 5-290
Range on HMM: 7-292/293.0
SDLDAQIEQIRSGKQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRY
..||..||...  |.|.|....||...|||||..|.|. |.| ...|.||.||...|||.|... | .| ....|.||.||||..|.| ..|| |||..|
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PERISILRGNHESRQITQVYGFYDECLRKYASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDRA
|... .||||||.......|||.||.|||| . ..| ...|... |||. |.. .|.. ||||||. ..|| ||...|....|.||...||||||||.. 
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

GWNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDPAP
||  |.||.|. || |. ..| ..|||. | |.||.|..|. . .|...||.||||||..|.||.|....||. |...| ...| .
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP7C_pd Subfamily PPP7C 5-184 4.5e-39 127.3 In-house 18-203 (383) alignment 
Range on Protein: 5-184
Range on HMM: 18-203/383.0
SDLDAQIEQIRSGKQLDEQQIKLLCEKAKEILSQESNVREVSC----PVTVCGDVHGQFYDLLELF-RIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVA
..... ||...  |.|  . . |.  .||..| |  |. .||      ||||||.||.. ||| .. . |   .. .|.| ||.||||  ||| . .|.|
deveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillilla

LKVRYPERISILRGNHESRQITQVYGFYDECLRKY--ASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSpQATTLDAIRDMDRFQ
| . ||. . . |||||   .   |||  |   ||   .  . . . |.| .|||. |....|. .|||.| . | |. .  ..| .
lllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_PPP6C_pd Subfamily PPP6C 6-282 6.1e-129 422.3 In-house 1-277 (290) alignment 
Range on Protein: 6-282
Range on HMM: 1-277/290.0
DLDAQIEQIRSGKQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYP
.||  ||.... | | |...| ||.. ...|..||||. ||.|||||||.|||||||.|||| ||.||.|.|.|.||.|||||.|.|..|.|..||..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

ERISILRGNHESRQITQVYGFYDECLRKYASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDRAG
.|| .|||||||||||||||||||||.|| . ..| |.|..||.|... ... |..|.||||||. .||| || ..| ||.||.|..|||.||||.|   
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYS
|.|||||||. ||. |..||...| |..|.||||||.||...  | ..||..|||||||||||   |..|.|. . .
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeere
subfamily_PPG1_pd Subfamily PPG1 7-291 4.5e-123 403.3 In-house 1-298 (300) alignment 
Range on Protein: 7-291
Range on HMM: 1-298/300.0
LDAQIEQIRSGKQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPE
||  .|...  . | |  .| |..| ||.| .|||| |. .|||| |||||||||.||.|.|||.|| |||||.|||||||..|||...||..||.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RISILRGNHESRQITQVYGFYDECLRKY-ASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPD----
||..||||||||||||||||| ||||||   . || |.|..||.| |. ... .|.|.||||||.. ..| |. .|||.|||.|| ..|||||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DRAG--WNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDPAPR
      || |  . ||.||||. .|| | |.| |.| .. | |||||..||..   |  . |..|||||||||||.  |.|| . ... |  |. ||.
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 9-290 2.4e-96 315.3 In-house 13-295 (298) alignment 
Range on Protein: 9-290
Range on HMM: 13-295/298.0
AQIEQIRSGKQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERI
. ... .  |...|.... |.|.||.|... . . ||  |..||||.|||. ||| ||  .|  |..||||.||||||| ...| ..||.| ||.||...
vslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnf

SILRGNHESRQITQVYGFYDECLRKYASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDD-RAGWN
 .||||||  .| .|||||.|| |.|.| .... | |.|. ||||.|.  .|.|.|||||.. ..|| .|.. | .. ..|    ||||.||..   ||.
fllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwa

VSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDPAP
 . ||... ||. | ...  .  . ...||||.| .|...  ....|||||||.|| .  |  ..|..|. |  ||  . |. 
ensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_PPP5C_pd Subfamily PPP5C 10-292 3.6e-86 282.1 In-house 24-312 (322) alignment 
Range on Protein: 10-292
Range on HMM: 24-312/322.0
QIEQIRSGKQLDEQQIKLLCEKAKEILSQESNVREVSCP----VTVCGDVHGQFYDLLELFRIGGEVPHT-NYLFMGDYVDRGYFSVEAVTLLVALKVRY
 .|.... |.| .. .  .  .|||.|.... . |.. .    .|||||.||||||||..|.. | . ..  ||| ||.|||| |||| . .|...|. |
llelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfklly

PERISILRGNHESRQITQVYGFYDECLRKYASpAVWTYFTDLFDFLPLTGLVERQIFCLHGGLS-PQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDR
|... . |||||| .. ..||| .|.  ||.. .|   ||..|..|||. ... ... .||||   .  ||| .| .||... |.|| ...||||||...
PnhfflsrGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea

AGWNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMEL-DDTLNYSFLQYDPAPRP
.| . | || |..||  |...| ..|.|. | |.|.. .||.. .|| ...|.||||||| . ||.|....| .| |.  | ...  . |
nGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeavehp
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 15-291 1.1e-88 290.3 In-house 19-296 (299) alignment 
Range on Protein: 15-291
Range on HMM: 19-296/299.0
RSGKQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGN
|  | ..||... ||. ||... ... . ||  |. ||||.|||. ||| .| . |  |..|.||.|||||||   .| .|||.. |..||||. .||||
rltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgn

HESRQITQVYGFYDECLRKYASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDR-AGWNVSPRGA
||   | .|||||.|| ..|.|  .|. | | |...|||||.  .|.|.||||||. .||| .||. | |. |      ||||.|||.   .|    || 
hecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgv

GFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDPAPR
 . ||. | ..   . .. ..|||||.| .|...  ....||||||| || .  |   ||..|. |  .|  . |.|.
syvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpk
subfamily_PPP3C_pd Subfamily PPP3C 15-291 7.3e-87 285.0 In-house 36-324 (452) alignment 
Range on Protein: 15-291
Range on HMM: 36-324/452.0
RSGKQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGN
    .|.|...  . |.| ..|..|... ||. |.||.||.||||||||.|| .||.  .|.|||.||||||||||.|.|  | |||. ||... .||||
lkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGn

HESRQITQVYGFYDECLRKYASpAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDRAGWNV------
||.| .|. . | .||  ||   .|.  ... || |||. |...| .|.||||||. ..|| |...|||.|.|. ||.|||||||| .. | .       
hecrhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfv

--SPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHD------RNVVTIFSAPNYCYRCGNQGGIMELDDTlNYSFLQYDPAPR
  |.||  . .. . . || ..| |  | |||.   .|..  ..        ..|.||||||.    |.. ......  .    |.. .| 
pnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn.vmnirqfnssph
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 17-70 3.4e-12 39.1 In-house 6-59 (317) alignment 
Range on Protein: 17-70
Range on HMM: 6-59/317.0
GKQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGG
 . ..|...  || .|.|.. .|   .|. .|||..||.|||| ||| |. . |
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_PPP1C_pd Subfamily PPP1C 18-284 5.8e-104 340.2 In-house 8-274 (282) alignment 
Range on Protein: 18-284
Range on HMM: 8-274/282.0
KQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHES
 .| |..|. |..||.||| ... . |.. ||...||.|||..||| || ..|  |..||||.||||||| .|.|...||.|.|..|||.. .|||||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhes

RQITQVYGFYDECLRKYASPaVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDD-RAGWNVSPRGAGFN
 .|...||||||| |.| .  .|  ||| |..|||. ||. .|.|.||||||. . |. ||.. |  |||..| .|||||||||. . ||. . ||  |.
asinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsft

FGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFL
|||.| |.| . | | .| ||||.| .|...  .|..||.||||||| . .|.|.....|..|  || 
fgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfq
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 18-285 6e-81 265.0 In-house 6-279 (284) alignment 
Range on Protein: 18-285
Range on HMM: 6-279/284.0
KQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEV------PHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISIL
| |.|...  || .|.|.. .|.  .|. .||...||.|||| ||| |. . |         ...|||.||||||| ||.| .||| |.|...|... .|
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRQITQVYGFYDECLRKYaSPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDR-AGWNVSP
||||||| . . |||| || ..| | |..  |   |  .||. .|...|.|.|||.| .   |. . ...|  ..|  | ..|| |.||. .  |.. ||
rgnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQ
||||  ||.   .||...  | .. ||||.||.|...  ||..||||||| || .  | . ....|. |  ||  
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftv
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 18-277 1.7e-56 184.6 In-house 4-288 (302) alignment 
Range on Protein: 18-277
Range on HMM: 4-288/302.0
KQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGG--E---------VPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPE
|....... ||.|.  | |..|... |.| |||. ||.|||| ||. ..      |           .  ..|.|||||||. |.| ..|. |||| ||.
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

RISILRGNHESRQITQVYGFYDECLRKYASP---AVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDR-FQEVPHEGPMCDLLWSDPDD
.  .||||||.. |   ||| .|   ...      .|  | . | |.||. || ..|.|.|||.||. ..|. |....| ..|| ..    |||..|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

RAGWNVSP----------RGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDD
  .  . .          ||  . | ..  ... .  .|..| |||| . |||..  |....||||||.|     |.| ....| 
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdt
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 18-277 2.3e-56 184.2 In-house 5-289 (302) alignment 
Range on Protein: 18-277
Range on HMM: 5-289/302.0
KQLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGG--E---------VPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPE
|....... ||.|.  | |..|... |.| |||. ||.|||| ||. ..      |           .  ..|.|||||||. |.| ..|. |||| ||.
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

RISILRGNHESRQITQVYGFYDECLRKYASP---AVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDR-FQEVPHEGPMCDLLWSDPDD
.  .||||||.. |   ||| .|   ...      .|  | . | |.||. || ..|.|.|||.||. ..|. |....| ..|| ..    |||..|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

RAGWNVSP----------RGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDD
  .  . .          ||  . | ..  ... .  .|..| |||| . |||..  |....||||||.|     |.| ....| 
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdt
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 19-285 2.5e-76 249.8 In-house 22-291 (297) alignment 
Range on Protein: 19-285
Range on HMM: 22-291/297.0
QLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESR
 . |...  | . | ... .. .. || .|. ||||.|||| ||| ||. ||  | .||||.||||||| ||.|.. ||.| ||..|  . .||||||  
viteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhece

QITQVYGFYDECLRKYASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSP---QATTLDAIRDMDRFQEVpHEGPMCDLLWSDPD-DRAGWNVSPRGAG
 . .|||||.|| ..| |  ... | |.|..||||||.  .|.|.||||||   .  |||..|...| .|  .|. ..||||.||    .|.    ||||
fvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrgag

FNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQ
  ||.    .      | ...||||.| .|...   |..||||||| || .  |   .|  |. |. ||  
cgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfei
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 19-288 2.7e-73 239.4 In-house 9-281 (287) alignment 
Range on Protein: 19-288
Range on HMM: 9-281/287.0
QLDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESR
 .....|  . ||..|||   . . ||  |.|..||.|||. ||| .|   |  |...|||.|||||||  |.| . || .||..||... .|||||| .
afsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevk

QITQVYGFYDECLRKYAsPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQE--VPHEGPMCDLLWSDPDDR-AGWNV-SPRGAG
.| ..|||..|  ||.    ..  | |.|. |||   |...|.|.|||.||.  .|| .. . . .     .|| . ||||.||.    . ..   |.  
kinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirais

FNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDP
  ||| . ... .. .. .| |||... ||...  |...||.|||| |. .  | | .. ....|. || .  |
vvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
PPP_3 20-287 4.5e-112 366.5 In-house 2-270 (271) alignment 
Range on Protein: 20-287
Range on HMM: 2-270/271.0
LDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQ
|.|...| |..|.||||..|||. |.| |||||||.|||..||||||..||..|.|.|||.|||||||..|.| ..||.|||..||... .|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDL-LWSDPDDRAGWNVSPRGAGFNFG
|..||||..|.|.|. .  |.......|..|||. |........||||||. ..|| |. ..|..|||.||...|| |.|||... |.. |.||||. ||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

KTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYD
. |.|||...| |..|.|||.|..||..  ||..|||.|||||||.|..|.| |..|...|...| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_PPZ_pd Subfamily PPZ 20-288 3.2e-78 256.3 In-house 25-293 (300) alignment 
Range on Protein: 20-288
Range on HMM: 25-293/300.0
LDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQ
| ...|  .| ||.|..  . .. |.| .| . ||||||. ||| ||   |  | .||||.|||||||  |.|.. ||.. |..||| . .||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECLRKYaSPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDR-AGWNVSPRGAGFNFG
.|.|||||||| |.     .|  | | |. |||. .|  .|||.||||||   ..| || . |  .||  | . ||||||| |    |.   ||  . . 
vtrvygfydeckrrc.nikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

KTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDP
|   ..|    |. ...||| .| .|...  ||..||.|||||||    | | .| . . |  ||   ||
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 20-288 2.7e-66 216.5 In-house 16-288 (290) alignment 
Range on Protein: 20-288
Range on HMM: 16-288/290.0
LDEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQ
. ...|  . ||..|||     . ||  |... ||.|||. .||. |   |  |. ..||.|||||||  |.|   ||  .|.||.... .|||||| |.
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

ITQVYGFYDECLRKYASpAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRF--QEVPHEGPMCDLLWSDPDD--RAGWNV-SPRGAG
. ..|||..|  || .|  .|  . |.|. |.|   |.|.|.|.|||.|..  . .... . .   .   .|| . ||||.||.       ..   |.  
vnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqrais

FNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDP
  ||| . ... .. .| .| |||..  ||||.  |...||.|||| |. .  | | |... ..|. |.    |
vvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
PPP_1 21-275 7.7e-110 359.3 In-house 2-264 (264) alignment 
Range on Protein: 21-275
Range on HMM: 2-264/264.0
DEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQI
 |.... |..|.||.|..|.|. ||| ..|||||.||||.|||.||..||..|.|||||.|||||||..||| ..||.|||..||... .|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDL--------LWSDPDDRAGWNVSPRG
|.||||..|.|.|. |  .. ..||.||.|||. |.. .|...||||||. ..|| || ..|..|||.||..|||        |..|.... ... |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMEL
||. ||| |.|.|...|.|..|.|||....||... ..|.|||||||.||.....|.| ...|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PP2Ac_SM00156 21-289 2.9e-106 347.4 In-house 2-270 (271) alignment 
Range on Protein: 21-289
Range on HMM: 2-270/271.0
DEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQI
...... |.|..||||.||.|..||| ||||.||.|||..|||.|.. .||.|...|.|.|||||||..|.| ..||.|||..|||.. .|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYaSPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDP-DDRAGWNVSPRGAGFNFGK
...|||..|. ||| .  ..  |...|. |||. ||...|.|.||||||. ..|| || ..|..| |.||...||||||| ..  |.. | ||... ||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

TVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDPA
 . .|| ..| |. | |||..|.||... .|...||||||||||....|.. .......|. |. |....
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 21-289 1.3e-82 270.1 In-house 7-275 (280) alignment 
Range on Protein: 21-289
Range on HMM: 7-275/280.0
DEQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQI
 | .|. . || |.||. .. . || .||.||||.|||. ||| ||   .  | .||||.||||||| . .| . ||.| |||||... |||||||  .|
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

TQVYGFYDECLRKYaSPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPD-DRAGWNVSPRGAGFNFGK
 . |||.||. |.| | |... | .|.| |||. ||  .|.|.|||||..  .|| .... |  . ..|    ||||.||. . .||  ..||.   ||.
nrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

TVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDPA
 |  .. .   . .||| ||.| .|...  |...||.||||.|.    |. ... .|. |  ||    ||
nvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 22-292 1.4e-81 266.8 In-house 10-280 (281) alignment 
Range on Protein: 22-292
Range on HMM: 10-280/281.0
EQQIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQIT
...|. .  ... |.|.|... |.  |..| ||.|.|| || .|| . | ||.. ..|.|||||||  |.|.. || .||.||..|| .||||||  .. 
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

QVYGFYDECLRKYASpAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDR-AGWNVSPRGAGFNFGKT
..|||| ||  ||    .|. |   |. ||...|..... |.||||||. |.|| .|.. .  . .. | . ||||.|||..  .|  | ||..| ||| 
kiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGkn

VSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDPAPRP
| ..  .. .. .| ||||.|..|..    |...|.||.||||    | . .. .|.||. |.... ||. |
vvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpasep
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 24-288 9.5e-68 221.7 In-house 7-273 (284) alignment 
Range on Protein: 24-288
Range on HMM: 7-273/284.0
QIKLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQITQV
... |  .| .|. ..  . ||  |. .|||.|||| ||| ||   |   ..||||.|||||||   .|.. ||.| || .|... .||||||   | ..
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYDECLRKYASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGP-MCDLLWSDPDD-RAGWNVSPRGAGFNFGKTV
||||.|| |.|  |.|.. |  .|  .||| || ..|.|.|||.|     .  .| . |  . |       |.||||| . . |||   ||  . ||   
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

SEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDP
  ..     . .. ||||.| .|...  .| .||||||| || .  |   .| ..  |  ||.   |
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 26-69 6.5e-07 21.7 In-house 17-60 (339) alignment 
Range on Protein: 26-69
Range on HMM: 17-60/339.0
KLLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIG
  || .|.|..  |  . .. .|. | ||.|||| ||| .. . 
aelchrareliwsepiflkleapicvmgdihgqfddllamldmn
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 27-289 4.2e-67 219.5 In-house 27-292 (307) alignment 
Range on Protein: 27-289
Range on HMM: 27-292/307.0
LLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQITQVYGF
 .  .|. |.| |  . ..  |. | ||.|||| ||...| . |  | | |.| ||||||| .|.|.. ||.. |. ||| | .||||||  .. . |||
nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygf

YDECLRKYA--SPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDR-AGWNVSPRGAGFNFGKTVSE
|.||.         .|. |   |. ||.. |.  .|.|.||||||  | || .|.  .    |  | . |.||.|||     |. | ||.|| ||  | .
yeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnvid

EFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDPA
.  .  |. .| ||||....|.     |...|||||| ||    | | .. .|.||    . . |.
dvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpe
subfamily_PPPLV_pd Subfamily PPPLV 27-265 7.3e-50 162.9 In-house 4-266 (290) alignment 
Range on Protein: 27-265
Range on HMM: 4-266/290.0
LLCEKAKEILSQESNVREVSCPVTVCGDVHGQFYDLL----ELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQITQ
 ||..| .|| .| .. |.  |. | ||.||.. ||      |.|.| ..  ...||.||||||| |||| .. |.|||| || .. .|||||| . ...
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

VYGFYDECLRKYAS--PAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATT---LDAIRDM-DRFQEVPHEGPM-CDLLWSDPDDR------------
 . .. |.  |.      ||  |.. ||.|||.  ..|..|| |.|.   . |   . ||.|. .|...  .  |.  |.|||||..             
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

AGW--NvSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYR
.|.  | . || |  |..   | | . |.|  . |||.   .|..  ..  ..|.||. .||  
eGfvdn.drrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 32-294 2.2e-70 230.3 In-house 18-280 (280) alignment 
Range on Protein: 32-294
Range on HMM: 18-280/280.0
AKEILSQESNVREVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQITQVYGFYDECL
 . |. .|||. |  .|. | ||.| |. |.  || . | ||  . .|.|||||||   .| . ||..||.|| .|| .||||||.  . ..|||| || 
veaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecq

RKYASpAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDLLWSDPDDR-AGWNVSPRGAGFNFGKTVSEEFNRTNG
 ||.  ..|  |   |. .|..||. ....|.||||||.   ||.||.. |  |    | . ||||||| ..  ||  | ||  . ||| | |.  ..  
ykygv.glwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksle

LRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDPAPRPQG
. .| ||||.| .|..    | ..|.|| |||| .  |   .. |.  |. || |  | | |.|
idliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippplpeg
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 44-288 1.7e-55 181.5 In-house 4-255 (263) alignment 
Range on Protein: 44-288
Range on HMM: 4-255/263.0
EVSCPVTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQITQVYGFYDECLRKYAS----PAV
|. .|. .||| |||. ||| .|   |   .|.|||.||||||| .|.| . ||..||.  | .. .|||||| . | . |||. |  ...       .|
elqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesv

WTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPM-CDLLWSDPDD-RAGWNVSP-RGAGFNFGKTVSEEFNRTNGLRIIAR
. .| ..| ..||  .| ..|.|.|||.||.  .|| || .    |  .  |. |||||.||.    |..    |     |||   ... .   . .| |
ynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivr

AHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDP
|||.|  |. .  || ..|.|||  |     |   .. ..  |. ||.|  |
ahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
Metallophos Calcineurin-like phosphoesterase 48-240 8.3e-40 130.2 Pfam-A 2-198 (200) alignment 
Range on Protein: 48-240
Range on HMM: 2-198/200.0
PVTVCGDVHGQFYDL----LELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLL--VALKVRYPERISILRGNHESRQITQVYGFYDECL----------
...|.||.||...||    |.|..|..| . ...||.||.||||  | |   ||   .||...| ..  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYASPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTLDAIrdmdrfqevphegpmcdllwsdpddragwnv
                       ...  . .. .. . |..|||  ||. .|.. ||.||.   . | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGFNFGKTVSEEFNRTNGLRIIARAHQL
    ....||. . |.. . .|. .. |.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 49-240 3e-76 248.5 In-house 1-197 (198) alignment 
Range on Protein: 49-240
Range on HMM: 1-197/198.0
VTVCGDVHGQFYDLLELFRIGGEVPHTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQITQVYGFYDECLRKYASPAVWTYFTDLFD
||||||.|||..|||.||. |...|...|||.|||||||..|.| ..||.|||..||... .|||||||.....||||..|.|.|. . .|.......|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

FLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVPHEGPMCDL-----LWSDPDDRAGWNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQL
.|||. |........|||||.. ..|| |. ..|..|.|.||...||     |....... ... | ||||. ||. |.||. ..| |..| |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 49-240 1.5e-72 236.8 In-house 1-196 (197) alignment 
Range on Protein: 49-240
Range on HMM: 1-196/197.0
VTVCGDVHGQFYDL-LELFRIGGEVP-HTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQITQVYGFYDECLRKyASPAVWTYFTDL
|||.||.|||..|| |.|...||. . ...|.|.|||||||..|.| ..||.|||..||... .|||||||......|||..|.|.|  .  .. ...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVP-HEGPMCDL-LWSDPD-DRAGWNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQL
||.|||. |........|||||.. ..|| |....|..|.| .|. ..|| |||||  .  |.. | ||||. ||..| |.| ..|.|..| |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 49-240 3.5e-70 229.0 In-house 1-198 (199) alignment 
Range on Protein: 49-240
Range on HMM: 1-198/199.0
VTVCGDVHGQFYDL-LELFRIGGEVP-HTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQITQVYGFYDECLRKYASPAVWTYFTDL
||||||.|||..|| |.||. ||. . ...|.|.|||||||..|.| ..||.|||..||... .||||||..|....|||..|.|.|| .  .. ...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDFLPLTGLVERQIFCLHGGLSPQATTLDAIRDMDRFQEVP-HEGPMCDL-LWSDPD-DRAG-WNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQL
||.|||. |........||||||.  ... .....|..|.| ..| ..|| |||||  .  | .  | ||||. ||..| |.| ..|.|  | |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 49-122 1.4e-07 24.3 In-house 12-81 (235) alignment 
Range on Protein: 49-122
Range on HMM: 12-81/235.0
VTVCGDVHGQFYDLLELFR--IGGEVPHTNYLFMGDYVDRGYFSVEAVTLLvalkvrYPERISILRGNHESRQITQ
. | ||||| . .|.||.   |||  .    ...|| ...|  |||.| ..        .    ..||||   . .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvlla
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 74-288 3.1e-71 233.1 In-house 100-314 (317) alignment 
Range on Protein: 74-288
Range on HMM: 100-314/317.0
HTNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQITQVYGFYDECLRKYaSPAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATT
. .|||.||||||| ||.| |.||.|||..||... .|||||||| . . |||| |. ..| | |..  |   |  |||. .|. .|.|.|||.| . . 
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDAIRDMDRFQEVPHEGPMCDLLWSDPDDR-AGWNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGI
|. .  ..|  ..|  | ..|| |.||| .  |.. |.||||. ||..  .||...  | .. ||||.|..|...  ||..|||||||.|| .  | . .
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

MELDDTLNYSFLQYDP
...|. |. |.  . |
lsvdkklkisinvlrp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 75-290 2.8e-55 180.8 In-house 120-335 (339) alignment 
Range on Protein: 75-290
Range on HMM: 120-335/339.0
TNYLFMGDYVDRGYFSVEAVTLLVALKVRYPERISILRGNHESRQITQVYGFYDECLRKYASpAVWTYFTDLFDFLPLTGLVERQIFCLHGGLSPQATTL
  |||.||||||| ||.| | || |||. ||.|| .|||||||| .   |||| |   .| .  ..  | ..|. .|.  ...  |.|.|||.| . |..
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsf

DAIRDMDRFQEVPHEGPMCDLLWSDPDD-RAGWNVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIM
. .  . |  |.|  | . || |.|||    |.. | ||| | ||      | .   |... | ||.| .|...   | .|||||||||| .  |   ..
nqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavf

ELDDTLNYSFLQYDPAP
 .|  |. |   . |  
sidkklkisinvfrpes
subfamily_PPP7C_pd Subfamily PPP7C 192-288 7.2e-21 67.3 In-house 237-334 (383) alignment 
Range on Protein: 192-288
Range on HMM: 237-334/383.0
MCDLLWSDPDDRAGW-NVSPRGAGFNFGKTVSEEFNRTNGLRIIARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQGGIMELDDTLNYSFLQYDP
. |.|||||  . |    . ||.|  ||  |.... .  .|... |.|.  .||....||..|.||||| ||     |.|  . | ..|.  ..||  
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqa